CN109125384A - A kind of bubble foot vinegar and preparation method thereof promoting sleep - Google Patents
A kind of bubble foot vinegar and preparation method thereof promoting sleep Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/486—Millettia
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A61P25/20—Hypnotics; Sedatives
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/10—Preparation or pretreatment of starting material
- A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment
Abstract
The invention discloses the sleep of a kind of promotion bubble foot vinegar and preparation method thereof, in particular to a kind of preparation method for using glutinous rice to carry out spontaneous fermentation vinegar liquid for raw material, it is additionally added a certain amount of Chinese medicine enzymolysis liquid, Chinese medicine enzymolysis liquid is by Radix Angelicae Sinensis, Caulis Spatholobi, climbing groundsel and wild chrysanthemum composition, by digesting under the action of complex enzyme into liquid, raw material, which is collectively constituted, with glutinous rice carries out vinegar fermentation, in alcohol fermentation processes, using the yeast liquid fermentation raw material of optimization, make active ingredients from traditional Chinese medicinal in conjunction with the ethyl alcohol after fermentation, increase curative effect, organic carbohydrate in Chinese medicine can also be converted to alcohols material simultaneously；Process is being acetified, using the acetic acid bacterium solution of optimization, alcohols material in fermented tcm material, the small molecule acetic acid for obtaining macromolecule organic acid, and fermenting out can also increase that its is fat-soluble with the hydroxy combining of Chinese medicine, improve curative effect；By the above process, the present invention provides a kind of bubble foot vinegar preparation method significant in efficacy.
Description
Technical field
The present invention relates to a kind of bubble foot vinegar and preparation method thereof for promoting sleep, belong to vinegar product technique field.
Background technique
Vinegar (Vinegar) is flavouring traditional in the Chinese major styles of cooking.According to existing literature record, ancient Chinese labour people
The people are using wine as leavening come the brewing vinegar that ferments, and east vinegar is originating from China, at least according to the wine vinegar history being documented
At 3,000 years or more." vinegar " is it was called in ancient China that " jealous woman ", " acyl ", " Bitters " etc.." tenth of the twelve Earthly Branches " is the earliest inscriptions on bones or tortoise shells of " wine " word.While "
Vinegar " is referred to as " Bitters ", it is also the same to illustrate that " vinegar " is initiated by " wine ".
Ancient Chinese medicine doctor is a lot of to the discussion of vinegar.Such as Zhong Jing treatise on Febrile Diseases cloud: " shaoyin disease, throat injury, raw sore, agraphia,
Sound not go out person, Bitters soup master it." " medical secrets of official ": " day row disease four or five days, accumulation of pathogens in chest expires pain high fever, the non-kuh-seng vinegar medicine of day row viral disease
It does not understand.Clinically, some Chinese medicine is processed through vinegar, can increase its it is soothing the liver enter liver, blood circulation promoting and dispersing pathogen accumulation effect.Such as give birth to turtle shell, the pig iron is fallen, Yuan
Flower, magnetite, native copper, blood clam, Piper longum, trigone, curcuma zedoary, red halloysite, raddle, actinolite, crotons, amethyst etc., use vinegar
Soak, fry, boiling, processing, forge after use, can eliminate or reduce drug toxicity, change its performance.In Linchuan application aspect, vinegar can be used
The curative effects such as carry out compound for preventing flu, relieve fatigue.
Steeping foot is exactly lavipeditum, belongs to one of Chinese medicine pedicure content and a kind of common external therapy.With hot water bubble
Foot not only recovered from fatigue, but also was conducive to sleep.Meanwhile Chinese medicine of adding some points in water, other can also be played the role of.Soaking feet with hot water can improve
Local blood circulation drives away cold, promotes metabolism, is finally reached the purpose of health care.With suitable Traditional Chinese medicine foot bath to tinea pedis
Also it has certain effect.
The present invention develops a kind of bubble foot vinegar preparation method for improving sleep quality, the present invention uses by studying for many years
The method of spontaneous fermentation organically combines its effective component and small molecule vinegar, improves health-care efficacy from source fermented tcm material.
Summary of the invention
To solve the above-mentioned problems of the prior art, the present invention provides a kind of bubble foot vinegar for promoting sleep and its preparation side
Method, the resulting bubble foot vinegar preparation method of the present invention is simple controllably, is suitable for industrialization production, has significant in efficacy.
In order to achieve the above objectives, embodiment of the present invention is as follows:
(1) raw material prepare: glutinous rice being impregnated with purified water, the water surface is higher by 5-10 centimetres of rice layer, impregnates 5-8 hours, impregnates
Carry out in the process it is intermittent vacuumize and vacuum breaker, changed using pressure difference and promote mass transfer and shorten soaking time, environment temperature
The glutinous rice soaked is drained, is put into heating tank at 10-30 DEG C by control, and addition is equivalent to 2-4 times of the glutinous rice water measured, and is heated to
Water boiling after keeping the temperature 5min, is added the Chinese medicine enzymolysis liquid of 0.2-0.8 times of glutinous rice quality, continues to boil 10-20min, be cooled to room
Temperature.
Preferably, the Chinese medicine enzymolysis liquid is made of Radix Angelicae Sinensis, Caulis Spatholobi, climbing groundsel and wild chrysanthemum；The ratio of composition
Mass ratio column are as follows:
40-60 parts of Radix Angelicae Sinensis
30-50 parts of Caulis Spatholobi
10-20 parts of climbing groundsel
10-20 parts of wild chrysanthemum.
Preferably, the Chinese medicine enzymolysis liquid the preparation method is as follows:
1, it takes Radix Angelicae Sinensis, Caulis Spatholobi, climbing groundsel and wild chrysanthemum to crushed 20 meshes, is added in enzymatic vessel, addition is equivalent to above-mentioned
The water that 2-4 times of four kinds of Chinese medicine gross masses is measured, for heated constant temperature to 50-60 DEG C, it is 7-8 that alkali regulator, which is added, and adjusts pH value, is added
Enter the 0.5-1.5% cellulose complex enzyme for being equivalent to above-mentioned four kinds of Chinese medicine gross masses, digests 3-6 hours.
Preferably, the potency of the cellulose complex enzyme is not less than 5000 units
2, after having digested, it is heated to 90-100 DEG C, constant temperature 10-20 minutes, is cooled to room temperature, cross 200 meshes.
Preferably, the alkali regulator is by one of sodium hydroxide, potassium hydroxide, sodium carbonate, potassium carbonate or several
Kind composition.
(2) alcohol fermentation: said mixture is added into fermentor, and the yeast liquid of optimization, room temperature is added in stirring
It is kept for 15-25 DEG C, fermented 4-8 days.
Preferably, the optimization yeast liquid additional amount is the 0.5-1.5% of whole system quality in fermentor.
Preferably, the optimization yeast liquid the preparation method is as follows:
1, it takes potato 2kg to remove the peel, is cut into block and adds water, boil 10-15min, three tert-butyl alcohol 50g are added, stir and evenly mix, sugaring
200g water supplies water to 10L, is packed into triangular flask, high-temp steam sterilizing.
2, yeast seeds are taken, are seeded in above-mentioned culture medium, inoculum concentration is that 1kg is inoculated with 1g barms, cultivates 3-6
It.
(3) it acetifies: appropriate purified water being added in above-mentioned fermentation liquid, the acetic acid bacterium solution of optimization is added, continues to ferment, room
Temperature is kept for 15-25 DEG C, is fermented 20-40 days.
Preferably, the purified water additional amount is 1-3 times of above-mentioned alcohol fermentation liquid quality.
Preferably, the optimization acetic acid bacterium solution additional amount is the 0.5-1.5% of solution gross mass in fermentor.
Preferably, the optimization acetic acid bacteria liquid and preparation method thereof is as follows:
1, peptone 100g, beef extract 30g, succinic acid 10g, sodium chloride 50g, agar 170g, distilled water 10L are taken, agar will be removed
Outer each ingredient is dissolved in distilled water, and adjusting pH is that 7.2(is adjusted using sodium hydroxide or hydrochloric acid), agar, packing is added
In in flask, 121 DEG C, 15min high pressure sterilization is spare.
2, strain Acetobacter xylinum is taken, is seeded in above-mentioned culture medium, inoculum concentration is that 1kg is inoculated with 0.5g acetic acid bacteria strain, cultivates 2-4
It.
(4) finished product: the above-mentioned fermentation liquid fermented being clarified, is filtered, and sealing saves 2-6 months, environment temperature 10-
20 DEG C.
Present invention is characterized in that
1. it is Chinese medicine that the present invention, which selects Radix Angelicae Sinensis, climbing groundsel, Caulis Spatholobi, wild chrysanthemum, the healthcare function of vinegar liquid is assisted, it then follows Chinese medicine
Evidence-based medicine EBM, Radix Angelicae Sinensis, Caulis Spatholobi have fine blood circulation promoting and enriching effect, complements each other with vinegar liquid effect of invigorating blood circulation；Climbing groundsel, mother chrysanthemum
Flower all has preferable detoxicating functions, improves health-care efficacy of the invention.
2. the saccharomycete in fermentation process of the present invention is by obtaining a kind of pair of insensitive ferment of alcohol under the stimulation of three tert-butyl alcohols
Female bacterium, the Chinese medicine enzymolysis liquid containing a large amount of hydroxy groups molecule will not influence the fermentation of saccharomycete, while saccharomycete can also
By the sugar alcoholization in Chinese medicine, macromolecule Organic Alcohol is obtained, its absorption is increased, improves curative effect.
3. the present invention, during acetifying, acetic acid bacteria occurs certain mutation, makes acetic acid bacteria to acid under succinic acid stimulation
Property substance have very strong tolerance, during the fermentation, the acetic acid of formation can also be with the meta-alkalescence substance knot in Chinese medicine
It closes, forms the lipid material for being easier to absorb, increase health-care efficacy.
The beneficial effects of the present invention are:
1. it is strong that the present invention obtains a kind of promotion sleep effect, the good bubble foot vinegar of duration.
Preparation process of the present invention is simple, and controllability is strong, is suitable for industrialization and large-scale production.
Specific embodiment
Main points in order to better understand the present invention are now described in further detail foregoing invention by specific embodiment, but under
Stating embodiment should not be understood as to further limitation of the invention.
Embodiment 1
It is a kind of bubble foot vinegar the preparation method is as follows:
1, raw material prepare: glutinous rice is impregnated with purified water, the water surface is higher by 8 centimetres of rice layer, impregnate 7 hours, in soaking process into
Row is intermittent to be vacuumized and vacuum breaker, is changed using pressure difference and is promoted mass transfer and shorten soaking time, environment temperature is controlled 20
DEG C, the glutinous rice soaked is drained, is put into heating tank, the water for being equivalent to 3 times of glutinous rice amounts is added, water boiling is heated to, keeps the temperature 5min
Afterwards, 0.5 times of glutinous rice quality of Chinese medicine enzymolysis liquid is added, continues to boil 15min, be cooled to room temperature.
The Chinese medicine enzymolysis liquid is made of Radix Angelicae Sinensis, Caulis Spatholobi, climbing groundsel and wild chrysanthemum；The specific mass of composition is than column
It is as follows:
50 parts of Radix Angelicae Sinensis
40 parts of Caulis Spatholobi
15 parts of climbing groundsel
15 parts of wild chrysanthemum.
2, alcohol fermentation: said mixture is added into fermentor, stirring, and the yeast liquid of optimization is added, and room temperature is protected
20 DEG C are held, is fermented 6 days.
The optimization yeast liquid the preparation method is as follows:
It takes potato 2kg to remove the peel, is cut into block and adds water, boil 12min, three tert-butyl alcohol 50g are added, stir and evenly mix, sugaring 200g water,
Water is supplied to 10L, is packed into triangular flask, high-temp steam sterilizing.Yeast seeds are taken, are seeded in above-mentioned culture medium, inoculum concentration is
1kg is inoculated with 1g barms, cultivates 5 days.
3, it acetifies: appropriate purified water being added in above-mentioned fermentation liquid, the acetic acid bacterium solution of optimization is added, continues to ferment, room temperature
It is kept for 20 DEG C, fermented 30 days.
The optimization acetic acid bacteria liquid and preparation method thereof is as follows:
Peptone 100g, beef extract 30g, succinic acid 10g, sodium chloride 50g, agar 170g, distilled water 10L are taken, it will be in addition to agar
Each ingredient be dissolved in distilled water, adjusting pH is that 7.2(is adjusted using sodium hydroxide or hydrochloric acid), agar is added, is sub-packed in
In flask, 121 DEG C, 15min high pressure sterilization is spare；Strain Acetobacter xylinum is taken, is seeded in above-mentioned culture medium, inoculum concentration connects for 1kg
Kind 0.5g acetic acid bacteria strain, is cultivated 3 days.
4, finished product: the above-mentioned fermentation liquid fermented being clarified, is filtered, and sealing saves 4 months, and environment temperature is 15 DEG C, i.e.,
It can.
Embodiment 2
It is a kind of bubble foot vinegar the preparation method is as follows:
1, raw material prepare: glutinous rice being impregnated with purified water, the water surface is higher by 10 centimetres of rice layer, impregnates 8 hours, in soaking process
Carry out it is intermittent vacuumize and vacuum breaker, changed using pressure difference and promote mass transfer and shorten soaking time, environment temperature control exists
30 DEG C, the glutinous rice soaked is drained, is put into heating tank, the water for being equivalent to 4 times of glutinous rice amounts is added, is heated to water boiling, heat preservation
After 5min, 0.7 times of glutinous rice quality of Chinese medicine enzymolysis liquid is added, continues to boil 20min, be cooled to room temperature.
The Chinese medicine enzymolysis liquid is made of Radix Angelicae Sinensis, Caulis Spatholobi, climbing groundsel and wild chrysanthemum；The specific mass of composition is than column
It is as follows:
60 parts of Radix Angelicae Sinensis
50 parts of Caulis Spatholobi
20 parts of climbing groundsel
20 parts of wild chrysanthemum.
2, alcohol fermentation: said mixture is added into fermentor, stirring, and the yeast liquid of optimization is added, and room temperature is protected
25 DEG C are held, is fermented 8 days.
The optimization yeast liquid the preparation method is as follows:
It takes potato 2kg to remove the peel, is cut into block and adds water, boil 15min, three tert-butyl alcohols are added, stir and evenly mix, sugaring 200g water, mend
Sufficient water is packed into triangular flask, high-temp steam sterilizing to 10L.Yeast seeds are taken, are seeded in above-mentioned culture medium, inoculum concentration 1kg
1g barms are inoculated with, are cultivated 6 days.
3, it acetifies: appropriate purified water being added in above-mentioned fermentation liquid, the acetic acid bacterium solution of optimization is added, continues to ferment, room temperature
It is kept for 25 DEG C, fermented 40 days.
The optimization acetic acid bacteria liquid and preparation method thereof is as follows:
Peptone 100g, beef extract 30g, succinic acid 10g, sodium chloride 50g, agar 170g, distilled water 10L are taken, it will be in addition to agar
Each ingredient be dissolved in distilled water, adjusting pH is that 7.2(is adjusted using sodium hydroxide or hydrochloric acid), agar is added, is sub-packed in
In flask, 121 DEG C, 15min high pressure sterilization is spare；Strain Acetobacter xylinum is taken, is seeded in above-mentioned culture medium, inoculum concentration connects for 1kg
Kind 0.5g acetic acid bacteria strain, is cultivated 4 days.
4, finished product: the above-mentioned fermentation liquid fermented being clarified, is filtered, and sealing saves 6 months, and environment temperature is 20 DEG C, i.e.,
It can.
Embodiment 3
It is a kind of bubble foot vinegar the preparation method is as follows:
1, raw material prepare: glutinous rice being impregnated with purified water, the water surface is higher by 5 centimetres of rice layer, impregnates 5.5 hours, in soaking process
Carry out it is intermittent vacuumize and vacuum breaker, changed using pressure difference and promote mass transfer and shorten soaking time, environment temperature control exists
10 DEG C, the glutinous rice soaked is drained, is put into heating tank, the water for being equivalent to 2 times of glutinous rice amounts is added, is heated to water boiling, heat preservation
After 5min, 0.3 times of glutinous rice quality of Chinese medicine enzymolysis liquid is added, continues to boil 10min, be cooled to room temperature.
The Chinese medicine enzymolysis liquid is made of Radix Angelicae Sinensis, Caulis Spatholobi, climbing groundsel and wild chrysanthemum；The specific mass of composition is than column
It is as follows:
40 parts of Radix Angelicae Sinensis
30 parts of Caulis Spatholobi
10 parts of climbing groundsel
10 parts of wild chrysanthemum.
2, alcohol fermentation: said mixture is added into fermentor, stirring, and the yeast liquid of optimization is added, and room temperature is protected
15 DEG C are held, is fermented 4 days.
The optimization yeast liquid the preparation method is as follows:
It takes potato 2kg to remove the peel, is cut into block and adds water, boil 10min, three tert-butyl alcohols are added, stir and evenly mix, sugaring 200g water, mend
Sufficient water is packed into triangular flask, high-temp steam sterilizing to 10L.Yeast seeds are taken, are seeded in above-mentioned culture medium, inoculum concentration 1kg
1g barms are inoculated with, are cultivated 3 days.
3, it acetifies: appropriate purified water being added in above-mentioned fermentation liquid, the acetic acid bacterium solution of optimization is added, continues to ferment, room temperature
It is kept for 15 DEG C, fermented 20 days.
The optimization acetic acid bacteria liquid and preparation method thereof is as follows:
Peptone 100g, beef extract 30g, succinic acid 10g, sodium chloride 50g, agar 170g, distilled water 10L are taken, it will be in addition to agar
Each ingredient be dissolved in distilled water, adjusting pH is that 7.2(is adjusted using sodium hydroxide or hydrochloric acid), agar is added, is sub-packed in
In flask, 121 DEG C, 15min high pressure sterilization is spare；Strain Acetobacter xylinum is taken, is seeded in above-mentioned culture medium, inoculum concentration connects for 1kg
Kind 0.5g acetic acid bacteria strain, is cultivated 2 days.
4, finished product: the above-mentioned fermentation liquid fermented being clarified, is filtered, and sealing saves 2 months, and environment temperature is 10 DEG C, i.e.,
It can.
Comparative example 1
It is a kind of bubble foot vinegar the preparation method is as follows:
1, raw material prepare: glutinous rice is impregnated with purified water, the water surface is higher by 8 centimetres of rice layer, impregnate 7 hours, in soaking process into
Row is intermittent to be vacuumized and vacuum breaker, is changed using pressure difference and is promoted mass transfer and shorten soaking time, environment temperature is controlled 20
DEG C, the glutinous rice soaked is drained, is put into heating tank, the water for being equivalent to 3 times of glutinous rice amounts is added, water boiling is heated to, keeps the temperature 5min
Afterwards, 0.7 times of glutinous rice quality of Chinese medicine enzymolysis liquid is added, continues to boil 15min, be cooled to room temperature.
The Chinese medicine enzymolysis liquid is made of Radix Angelicae Sinensis, Caulis Spatholobi, climbing groundsel and wild chrysanthemum；The specific mass of composition is than column
It is as follows:
50 parts of Radix Angelicae Sinensis
40 parts of Caulis Spatholobi
15 parts of climbing groundsel
15 parts of wild chrysanthemum.
2, alcohol fermentation: said mixture is added into fermentor, stirring, and yeast liquid is added, and room temperature is kept for 20 DEG C,
Fermentation 6 days.
3, it acetifies: appropriate purified water being added in above-mentioned fermentation liquid, the acetic acid bacterium solution of optimization is added, continues to ferment, room temperature
It is kept for 20 DEG C, fermented 30 days.
The optimization acetic acid bacteria liquid and preparation method thereof is as follows:
Peptone 100g, beef extract 30g, succinic acid 10g, sodium chloride 50g, agar 170g, distilled water 10L are taken, it will be in addition to agar
Each ingredient be dissolved in distilled water, adjusting pH is that 7.2(is adjusted using sodium hydroxide or hydrochloric acid), agar is added, is sub-packed in
In flask, 121 DEG C, 15min high pressure sterilization is spare；Strain Acetobacter xylinum is taken, is seeded in above-mentioned culture medium, inoculum concentration connects for 1kg
Kind 0.5g acetic acid bacteria strain, is cultivated 3 days.
4, finished product: the above-mentioned fermentation liquid fermented being clarified, is filtered, and sealing saves 4 months, and environment temperature is 15 DEG C, i.e.,
It can.
Comparative example 2
It is a kind of bubble foot vinegar the preparation method is as follows:
1, raw material prepare: glutinous rice being impregnated with purified water, the water surface is higher by 8 centimetres of rice layer, impregnates 6.5 hours, in soaking process
Carry out it is intermittent vacuumize and vacuum breaker, changed using pressure difference and promote mass transfer and shorten soaking time, environment temperature control exists
20 DEG C, the glutinous rice soaked is drained, is put into heating tank, the water for being equivalent to 3 times of glutinous rice amounts is added, is heated to water boiling, heat preservation
After 5min, 0.5 times of glutinous rice quality of Chinese medicine enzymolysis liquid is added, continues to boil 15min, be cooled to room temperature.
The Chinese medicine enzymolysis liquid is made of Radix Angelicae Sinensis, Caulis Spatholobi, climbing groundsel and wild chrysanthemum；The specific mass of composition is than column
It is as follows:
50 parts of Radix Angelicae Sinensis
40 parts of Caulis Spatholobi
15 parts of climbing groundsel
15 parts of wild chrysanthemum.
2, alcohol fermentation: said mixture is added into fermentor, stirring, and the yeast liquid of optimization is added, and room temperature is protected
20 DEG C are held, is fermented 6 days.
The optimization yeast liquid the preparation method is as follows:
It takes potato 2kg to remove the peel, is cut into block and adds water, boil 12min, three tert-butyl alcohol 50g are added, stir and evenly mix, sugaring 200g water,
Water is supplied to 10L, is packed into triangular flask, high-temp steam sterilizing.Yeast seeds are taken, are seeded in above-mentioned culture medium, inoculum concentration is
1kg is inoculated with 1g barms, cultivates 5 days.
3, it acetifies: appropriate purified water being added in above-mentioned fermentation liquid, acetic acid bacterium solution is added, continues to ferment, room temperature keeps 20
DEG C, it ferments 30 days.
4, finished product: the above-mentioned fermentation liquid fermented being clarified, is filtered, and sealing saves 4 months, and environment temperature is 15 DEG C, i.e.,
It can.
Comparative example 3
It is a kind of bubble foot vinegar the preparation method is as follows:
1, raw material prepare: glutinous rice being impregnated with purified water, the water surface is higher by 8 centimetres of rice layer, impregnates 5.5 hours, in soaking process
Carry out it is intermittent vacuumize and vacuum breaker, changed using pressure difference and promote mass transfer and shorten soaking time, environment temperature control exists
20 DEG C, the glutinous rice soaked is drained, is put into heating tank, the water for being equivalent to 3 times of glutinous rice amounts is added, is heated to water boiling, heat preservation
After 5min, 0.3 times of glutinous rice quality of Chinese medicine enzymolysis liquid is added, continues to boil 15min, be cooled to room temperature.
The Chinese medicine enzymolysis liquid is made of Radix Angelicae Sinensis, Caulis Spatholobi, climbing groundsel and wild chrysanthemum；The specific mass of composition is than column
It is as follows:
50 parts of Radix Angelicae Sinensis
40 parts of Caulis Spatholobi
15 parts of climbing groundsel
15 parts of wild chrysanthemum.
2, alcohol fermentation: said mixture is added into fermentor, stirring, and yeast liquid is added, and room temperature is kept for 20 DEG C,
Fermentation 6 days.
3, it acetifies: appropriate purified water being added in above-mentioned fermentation liquid, acetic acid bacterium solution is added, continues to ferment, room temperature keeps 20
DEG C, it ferments 30 days.
4, finished product: the above-mentioned fermentation liquid fermented being clarified, is filtered, and sealing saves 4 months, and environment temperature is 15 DEG C, i.e.,
It can.
Clinical tests
According to the preparation method in embodiment 1-3 and comparative examples 1-3, preparation bubble foot vinegar liquid chooses 60 60-65 years old, body
Body health, but suffer from the elderly of certain insomnia, is randomly divided into six groups, number 1-60, and elder generation lives one under identical environment
Week, guarantee daily diet, drinking-water, afternoon nap time consistency, second week six groups of old men of start recording fall asleep to for the first time at night
The time waken up.In third week, every group of old man uses the bubble foot of embodiment 1-3 and comparative example 1-3 before sleeping respectively
Vinegar foot 60min records every old man daily and is fallen asleep at night to the time waken up for the first time, and test result is as follows:
Table 1 in the case of not steeping foot, is fallen asleep in a week to first time wake-up time average value statistics
| Number | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | Average (h) |
| Time (h) | 5.1 | 4.5 | 4.8 | 5.6 | 4.9 | 6.0 | 4.8 | 3.6 | 3.4 | 4.9 | 4.76 |
| Number | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | - |
| Time (h) | 4.2 | 4.6 | 4.1 | 5.2 | 6.1 | 4.9 | 5.1 | 3.8 | 4.7 | 3.3 | 4.6 |
| Number | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | - |
| Time (h) | 3.3 | 3.8 | 4.5 | 4.2 | 5.1 | 4.3 | 4.6 | 5.1 | 3.1 | 3.4 | 4.14 |
| Number | 31 | 33 | 33 | 34 | 35 | 36 | 37 | 38 | 39 | 40 | - |
| Time (h) | 3.5 | 3.4 | 5.1 | 4.2 | 3.6 | 4.1 | 5.3 | 3.4 | 3.2 | 3.4 | 3.92 |
| Number | 41 | 44 | 43 | 44 | 45 | 46 | 47 | 48 | 49 | 50 | - |
| Time (h) | 5.1 | 4.3 | 4.6 | 4.5 | 3.2 | 4.1 | 4.2 | 5.1 | 3.8 | 4.6 | 4.35 |
| Number | 51 | 55 | 53 | 54 | 55 | 56 | 57 | 58 | 59 | 60 | - |
| Time (h) | 4.5 | 4.3 | 5.1 | 5.2 | 5.5 | 6.1 | 5.4 | 4.1 | 3.9 | 3.7 | 4.78 |
Table 2, grouping information table
| Embodiment | Embodiment 1 | Embodiment 2 | Embodiment 3 | Comparative example 1 | Comparative example 2 | Comparative example 3 |
| Number | 1-10 | 11-20 | 21-30 | 31-40 | 41-50 | 51-60 |
Table 3 is fallen asleep in a week in the case of steeping foot to first time wake-up time average value statistics
| Number | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | Average (h) |
| Time (h) | 7.2 | 7.8 | 8.1 | 7.5 | 7.7 | 8.4 | 6.9 | 6.5 | 7.5 | 7.8 | 7.54 |
| Number | 11 | 12 | 13 | 14 | 15 | 16 | 17 | 18 | 19 | 20 | - |
| Time (h) | 7.5 | 7.8 | 8.0 | 7.6 | 8.5 | 7.4 | 7.7 | 7.9 | 8.2 | 6.9 | 7.75 |
| Number | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 | - |
| Time (h) | 7.5 | 7.4 | 7.8 | 7.6 | 8.2 | 8.1 | 7.8 | 7.7 | 6.9 | 7.7 | 7.67 |
| Number | 31 | 33 | 33 | 34 | 35 | 36 | 37 | 38 | 39 | 40 | - |
| Time (h) | 5.4 | 5.4 | 5.6 | 4.8 | 6.1 | 5.5 | 6.2 | 5.8 | 5.8 | 5.6 | 5.62 |
| Number | 41 | 44 | 43 | 44 | 45 | 46 | 47 | 48 | 49 | 50 | - |
| Time (h) | 5.7 | 6.4 | 5.6 | 5.5 | 5.2 | 6.8 | 6.4 | 6.1 | 5.8 | 5.7 | 5.92 |
| Number | 51 | 55 | 53 | 54 | 55 | 56 | 57 | 58 | 59 | 60 | - |
| Time (h) | 4.8 | 4.9 | 5.1 | 6.2 | 5.4 | 6.7 | 5.4 | 4.5 | 5.6 | 5.8 | 5.44 |
From above-mentioned test data analyzer, present invention gained bubble foot vinegar has remarkable result in terms of sleep quality.
Claims (7)
1. a kind of bubble foot vinegar preparation method for promoting sleep, it is characterised in that including the following steps:
(1) raw material prepare: glutinous rice being impregnated with purified water, the water surface is higher by 5-10 centimetres of rice layer, impregnates 5-8 hours, impregnated
Carried out in journey it is intermittent vacuumize and vacuum breaker, changed using pressure difference and promote mass transfer and shorten soaking time, environment temperature control
The glutinous rice soaked is drained, is put into heating tank at 10-30 DEG C by system, and addition is equivalent to 2-4 times of the glutinous rice water measured, and is heated to water
Boiling after keeping the temperature 5min, is added the Chinese medicine enzymolysis liquid of 0.2-0.8 times of glutinous rice quality, continues to boil 10-20min, be cooled to room temperature
?；
(2) alcohol fermentation: said mixture is added into fermentor, stirring, and the yeast liquid of optimization is added, and room temperature is kept
It 15-25 DEG C, ferments 4-8 days；
(3) it acetifies: appropriate purified water being added in above-mentioned fermentation liquid, the acetic acid bacterium solution of optimization is added, continues to ferment, room temperature is kept
It 15-25 DEG C, ferments 20-40 days；
(4) finished product: the above-mentioned fermentation liquid fermented being clarified, is filtered, sealing, is saved 2-6 months, and environment temperature is 10-20 DEG C,
?.
2. promoting the bubble foot vinegar preparation method of sleep according to claim 1, it is characterised in that: the Chinese medicine enzymolysis liquid
It is made of Radix Angelicae Sinensis, Caulis Spatholobi, climbing groundsel and wild chrysanthemum, the specific mass of composition is as follows than arranging:
40-60 parts of Radix Angelicae Sinensis
30-50 parts of Caulis Spatholobi
10-20 parts of climbing groundsel
10-20 parts of wild chrysanthemum.
3. promoting the bubble foot vinegar preparation method of sleep according to claim 2, it is characterised in that: the Chinese medicine enzymolysis liquid
The preparation method is as follows:
(1) it takes Radix Angelicae Sinensis, Caulis Spatholobi, climbing groundsel and wild chrysanthemum to crushed 20 meshes, is added in enzymatic vessel, addition is equivalent to above-mentioned
The water that 2-4 times of four kinds of Chinese medicine gross masses is measured, for heated constant temperature to 50-60 DEG C, it is 7-8 that alkali regulator, which is added, and adjusts pH value, is added
Enter the 0.5-1.5% cellulose complex enzyme for being equivalent to above-mentioned four kinds of Chinese medicine gross masses, digests 3-6 hours；
(2) after having digested, it is heated to 90-100 DEG C, constant temperature 10-20 minutes, is cooled to room temperature, cross 200 meshes.
4. promoting the bubble foot vinegar preparation method of sleep according to claim 1, it is characterised in that: the optimization yeast liquid
Additional amount is the 0.5-1.5% of whole system quality in fermentor.
5. promoting the bubble foot vinegar preparation method of sleep according to claim 4, it is characterised in that: the optimization yeast liquid
The preparation method is as follows:
(1) it takes potato 2kg to remove the peel, is cut into block and adds water, boil 10-15min, three tert-butyl alcohol 50g are added, stir and evenly mix, sugaring
200g water supplies water to 10L, is packed into triangular flask, high-temp steam sterilizing；
(2) yeast seeds are taken, are seeded in above-mentioned culture medium, inoculum concentration be 1kg be inoculated with 1g barms, cultivate 3-6 days, i.e.,
It can.
6. promoting the bubble foot vinegar preparation method of sleep according to claim 1, it is characterised in that: the optimization acetic acid bacterium solution
Additional amount is the 0.5-1.5% of solution gross mass in fermentor.
7. promoting the bubble foot vinegar preparation method of sleep according to claim 6, it is characterised in that: the optimization acetic acid bacterium solution
The preparation method is as follows:
(1) peptone 100g, beef extract 30g, succinic acid 10g, sodium chloride 50g, agar 170g, distilled water 10L are taken, agar will be removed
Outer each ingredient is dissolved in distilled water, and adjusting pH is that 7.2(is adjusted using sodium hydroxide or hydrochloric acid), agar, packing is added
In in flask, 121 DEG C, 15min high pressure sterilization is spare；
(2) strain Acetobacter xylinum is taken, is seeded in above-mentioned culture medium, inoculum concentration is that 1kg is inoculated with 0.5g acetic acid bacteria strain, it cultivates 2-4 days,
?.
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| Country | Link |
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