CN109106931B

CN109106931B - Medicine for treating intractable renal edema and preparation method thereof

Info

Publication number: CN109106931B
Application number: CN201810967098.6A
Authority: CN
Inventors: 詹继红
Original assignee: Guiyang College of Traditional Chinese Medicine
Current assignee: Guiyang College of Traditional Chinese Medicine
Priority date: 2018-08-23
Filing date: 2018-08-23
Publication date: 2021-08-24
Anticipated expiration: 2038-08-23
Also published as: CN109106931A

Abstract

The invention discloses a medicine for treating intractable renal edema and a preparation method thereof. The cassia twig in the formula warms and unblocks meridians and collaterals, assists yang and regulates qi, the white paeony root nourishes blood and astringes yin, the ginger warms and clears channel and cold, the fennel regulates qi and clears channel and cold, the szechuan lovage rhizome invigorates blood and promotes qi circulation, the asarum dispels wind and cold, the earthworm dredges collaterals and removes blood stasis, the dried ginger warms and unblocks meridians and collaterals, and the Chinese yam tonifies spleen and kidney. The traditional Chinese medicine composition has the effects of warming and activating meridian, inducing diuresis and reducing edema by combining the medicines, can be used for treating intractable renal edema, has good curative effect, no drug resistance and no side effect, and achieves the aim of the invention.

Description

Medicine for treating intractable renal edema and preparation method thereof

Technical Field

The invention relates to a medicine for treating intractable renal edema and a preparation method thereof, belonging to the technical field of medicines.

Technical Field

Renal edema is edema caused by glomerular injury, reduced filtration function, and intermittent accumulation of excess fluid in tissues due to various primary or secondary factors. There is no unified definition of refractory edema, and it usually means that there is no edema with obvious improvement after diuresis or combined diuresis, and it often occurs in clinical cases of various nephropathy, heart failure, late stage of liver disease, and lymphatic reflux obstruction. The intractable renal edema is usually in a progressive exacerbation trend due to poor response to conventional detumescence therapy (such as low-salt diet and diuretic), is one of the more troublesome problems in the treatment of renal diseases, and is commonly seen in primary or secondary intractable nephrotic syndrome, diabetic nephropathy and other diseases. The intractable renal edema is mainly manifested as severe sunken edema of both lower limbs, even accompanied by ascites or hydrothorax, and is difficult to resolve by conventional treatment. At present, a plurality of methods are used for treating renal edema, western medicine mostly adopts methods such as diuresis or combined diuresis for treating the renal edema, and if the available blood volume is insufficient, plasma albumin, low molecular dextran and the like are supplemented, or blood purification technology is adopted to carry out ultrafiltration treatment dialysis to carry out single-ultrasound treatment measures for detumescence. Human serum albumin can be used as one of the more common medicines in the treatment means of renal refractory edema, but is a blood product, so the price is high, the risks of anaphylactic shock, blood-borne infection and the like exist, and the glomerular epithelial cell injury, namely 'protein overload nephropathy', is caused by the increase of the output of urine albumin due to excessive input of albumin. The low molecular dextran can effectively increase blood volume as a plasma substitute drug, so that the blood perfusion of the kidney is increased, glomerular high filtration is caused, adverse reactions are also emphasized, and a plurality of reports indicate that the low molecular dextran is easy to cause anaphylactic shock, acute kidney injury and even death. Although these therapies can achieve certain therapeutic effects in a short period of time, they have many side effects and high cost, and they should be used with caution clinically. Hemodialysis blood purification treatment is relatively damaging to patients on one hand, and also causes economic and mental burdens to patients due to high cost on the other hand.

In addition, the clinical treatment method for edema still mainly adopts diuretic, but is often unsatisfactory, many edema is shown to be intractable, even the application of a large dose of diuretic is difficult to resolve, and even serious edema or excessive use of diuretic causes thromboembolism and even renal failure, which brings great trouble to clinicians. Therefore, the search for a less toxic and effective detumescence measure is a popular topic of medical workers at present.

The invention content is as follows:

the invention aims to provide a medicine for treating refractory renal edema and a preparation method thereof. The medicine has the effects of warming and activating meridian, inducing diuresis and reducing edema, can be used for treating intractable renal edema, and has good curative effect, no drug resistance and no side effect.

In order to solve the technical problems, the invention adopts the following technical scheme: the medicine for treating intractable renal edema is prepared with cassia twig 200-280 weight portions, white peony root 280-320 weight portions, ginger 100-140 weight portions, fennel 60-100 weight portions, Chuanxiong rhizome 80-120 weight portions, asarum herb 40-80 weight portions, earthworm 80-120 weight portions, dried ginger 130-170 weight portions and Chinese yam 130-170 weight portions.

The medicine for treating refractory renal edema is mainly prepared from 260 parts by weight of cassia twig 220-290-one, 310 parts by weight of white peony root 290-one, 130 parts by weight of ginger 110-one, 70-90 parts by weight of fennel, 90-110 parts by weight of ligusticum wallichii, 50-70 parts by weight of asarum, 90-110 parts by weight of earthworm, 160 parts by weight of dried ginger 140-one and 160 parts by weight of Chinese yam 140-one.

The medicine for treating refractory renal edema is mainly prepared from 240 parts by weight of cassia twig, 300 parts by weight of white paeony root, 120 parts by weight of ginger, 80 parts by weight of fennel, 100 parts by weight of szechuan lovage rhizome, 60 parts by weight of asarum, 100 parts by weight of earthworm, 150 parts by weight of dried ginger and 150 parts by weight of Chinese yam.

A preparation method of the medicine for treating refractory renal edema is characterized in that the raw materials are taken, and conventional auxiliary materials are added, or the auxiliary materials are not added, and the medicine is processed according to a conventional process to prepare a medicinal preparation.

In the preparation method of the medicine for treating refractory renal edema, the pharmaceutical preparation is an external preparation.

In the preparation method of the medicine for treating refractory renal edema, the external preparation is powder, ointment, patch, tincture, spray or gel.

In the preparation method of the drug for treating refractory renal edema, the preparation method of the powder comprises the following steps: drying the above materials, and pulverizing into fine particles.

In the preparation method of the drug for treating refractory renal edema, the preparation method of the ointment is as follows:

(1) extracting the above materials with 5-7 times of 70% ethanol under reflux for 0.5-1.5 hr for 2-3 times, filtering the extractive solution, recovering ethanol from the filtrate, and concentrating to obtain extract with relative density of 1.10-1.12 at 50-60 deg.C to obtain product A;

(2) adding 3-5% of sorbitol and 3-5% of glycerol into product A, and heating to 85-90 deg.C for dissolving to obtain product B;

(3) heating 5-7% stearic acid, 4-6% stearin, 1-3% yellow vaseline, 5-7% polysorbate 80, 0.5-1.5% lanolin and 0.5-1.5% sucrose stearate to 85-90 deg.C, and melting to obtain product C;

(4) mixing and emulsifying the product B and the product C for 20-30min, keeping the temperature at 60-70 deg.C for 50-60 min, adding 0.2-0.5% benzoic acid and 0.1-0.2% ethylparaben, mixing, and packaging.

In the preparation method of the drug for treating refractory renal edema, the preparation method of the patch comprises the following steps:

(2) heating and melting rubber 30-40 wt%, rosin 30-40 wt%, vaseline 3-7 wt% and lanolin 10-20 wt% to obtain product B;

(3) adding the component B into the component A, mixing with 5-8 wt% of glycerol and 30-50 wt% of zinc oxide, stirring for 15-30 min to obtain medicinal materials, respectively placing backing material, medical polyester film and medicinal materials into patch coating equipment, grinding, forming, cutting, packaging, sealing, and packaging.

In the preparation method of the medicine for treating refractory renal edema, the preparation method of the tincture is as follows: weighing the raw materials according to the proportion of the prescription, adding 8-12 times of white spirit, and soaking for more than 30 days to obtain the traditional Chinese medicine.

The medicine is mainly prepared from cassia twig, white paeony root, ginger, fennel, ligusticum wallichii, asarum, earthworm, dried ginger and Chinese yam. Wherein, the cassia twig is pungent, sweet and warm in nature; meridian tropism includes heart, lung and bladder meridians. The functions are mainly used for sweating and relieving muscles, warming and activating channels, supporting yang and regulating qi, and calming the Chong and descending qi; can be used for treating wind-cold type common cold, abdominal psychroalgia, blood cold amenorrhea, arthralgia, phlegm retention, edema, palpitation, and galloping. White peony root, bitter and sour in nature and slightly cold in nature; meridian tropism enters liver and spleen meridians. The functions are mainly used for calming the liver, relieving pain, nourishing blood, regulating menstruation, astringing yin and arresting sweating; can be used for treating headache, vertigo, hypochondriac pain, abdominal pain, limb spasm and pain, blood deficiency, sallow complexion, menoxenia, spontaneous perspiration, and night sweat. Ginger, pungent in nature and flavor, slightly warm; meridian tropism entering lung, spleen and stomach meridians; the functions are mainly used for relieving exterior syndrome and dispelling cold, warming middle-jiao and arresting vomiting, and reducing phlegm and relieving cough; can be used for treating common cold due to wind-cold, emesis due to stomach cold, and cough due to cold-phlegm. Fennel, pungent in nature and warm; meridian tropism entering liver, kidney, spleen and stomach meridians; the functions are mainly used for dispelling cold and relieving pain, and regulating qi and harmonizing stomach; can be used for treating abdominal pain due to hernia of cold, testis tenesmus, dysmenorrhea, cold pain of lower abdomen, abdominal distention and pain, anorexia, vomiting, diarrhea, and hydrocele of tunica vaginalis of testis; the salt fructus Foeniculi has effects of warming kidney, dispelling cold, and relieving pain. Can be used for treating abdominal pain due to hernia of cold, tenesmus of testis, and cold abdominal pain due to meridian obstruction. Chuan Xiong, pungent in flavor and warm in nature; meridian tropism entering liver, gallbladder and pericardium meridian; the functions are mainly used for activating blood and promoting qi circulation, and dispelling wind and relieving pain; can be used for treating menoxenia, amenorrhea, dysmenorrhea, abdominal pain, pricking pain in chest and hypochondrium, traumatic injury, swelling and pain, headache, and rheumatalgia. Asarum herb, pungent in flavor and warm in nature; meridian tropism is in the heart, lung and kidney meridians; the functions are mainly used for expelling wind and clearing away cold, promoting the restoration consciousness and relieving pain, and warming lung and resolving fluid retention; can be used for treating wind-cold type common cold, headache, toothache, nasal obstruction, nasosinusitis, rheumatalgia, phlegm retention, asthma, and cough. Earthworm, salty in property and taste and cold in nature. Meridian tropism entering liver, spleen and bladder meridians; the functions are mainly used for clearing heat and arresting convulsion, dredging collaterals, relieving asthma and promoting urination; can be used for treating hyperpyrexia, unconsciousness, epilepsy, convulsion, arthralgia, numbness of limbs, hemiplegia, cough and asthma due to lung heat, oliguria, edema, and hypertension. Zingiberis rhizoma, pungent and hot in nature; meridian tropism entered spleen, stomach, kidney, heart and lung meridians; the main functions are that the dried ginger warms the middle-jiao to dispel cold, returns yang to dredge vessels, eliminates dampness and dissolves phlegm; can be used for treating abdominal psychroalgia, emesis, diarrhea, cold limbs, slight pulse, phlegm retention, asthma, and cough. Chinese yam, sweet in nature and taste and mild in nature; meridian tropism entered spleen, lung and kidney meridians; the functions are mainly used for tonifying spleen and nourishing stomach, promoting the production of body fluid and benefiting lung, and tonifying kidney and arresting seminal emission; can be used for treating spleen deficiency, anorexia, chronic diarrhea, lung deficiency, cough, asthma, spermatorrhea, leukorrhagia, frequent micturition, and diabetes due to deficiency heat. The bran-parched rhizoma Dioscoreae has effects of invigorating spleen and invigorating stomach. Can be used for treating spleen deficiency, anorexia, diarrhea, loose stool, and leukorrhagia.

The raw materials are adopted to prepare the medicine, the components have good synergistic effect, the cassia twig in the formula warms and unblocks meridians, assists yang and regulates qi, the white paeony root nourishes blood and astringes yin, the ginger warms and clears channel and dispels cold, the fennel regulates qi and dispels cold, the ligusticum wallichii activates blood and promotes qi, the asarum dispels wind and dispels cold, the earthworm dredges collaterals and removes stasis, the dried ginger warms and unblocks meridians, and the Chinese yam tonifies spleen and kidney. The traditional Chinese medicine composition has the effects of warming and activating meridian, inducing diuresis and reducing edema by combining the medicines, can be used for treating intractable renal edema, has good curative effect, no drug resistance and no side effect, and achieves the aim of the invention.

Treatment example statistics

Firstly, clinical observation:

1. general condition of the patient

78 patients with refractory renal edema, 32 men and 46 women, aged 18-70 years, mean age 52 + -5.5. The group was divided into 41 cases of treatment group and 37 cases of control group, and the primary onset was as shown in table 1:

table 1 packet situation statistics

Grouping	Treatment group (case)	Control group (example)
			Chronic nephritis	15	13
Diabetic nephropathy	19	18
			Primary nephrotic syndrome	7	6

Except for thrombosis and embolism.

2. The treatment measures are as follows:

2.1 basic treatment:

2.1.1 general treatment: salt limitation and water limitation;

2.1.2 according to the requirements of the disease, hypotensor, hormone or immunosuppressant, lipid-lowering, anticoagulation and symptomatic support treatment are used conventionally;

the benazepril hydrochloride, the valsartan and/or the levamlodipine besylate tablets are selected for reducing blood pressure; the hormone or immunosuppressant is selected from oral prednisone acetate or methylprednisolone tablet, cyclophosphamide or cyclosporin A or mycophenolate mofetil; selecting atorvastatin for reducing blood fat; anticoagulation selects low molecular heparin. Furosemide intravenous drip 120mg/d is selected for symptomatic treatment.

2.1.2.1 for patients with elevated blood pressure, ACEI/ARB or CCB is added to make blood pressure fluctuation below 140/90 mmHg;

2.1.2.2 for patients with hyperglycemia, regulating insulin level to control blood sugar at 6-8mmol/L with fasting blood and 12-13mmol/L after 2 hours;

2.2 treatment groups: all patients were treated with the traditional Chinese medicine of the present invention (prepared as in example 1) topically, specifically: the medicine is prepared into paste by warm water with the temperature of about 45-55 ℃, the prepared medicine is applied to gauze with the thickness of about 2cm, and the gauze is applied to the areas of the two lower limbs and the two kidneys of a patient; it can be applied to navel (Shenque acupoint) for patients with ascites. Irradiating with infrared lamp for 20-30min, waiting for 5min, and removing gauze after residual heat is dissipated. 1-2 times daily.

2.3 control group was basal only.

3. Course of treatment

And 15d is an observation time limit.

4. Observation index

Observing the change of edema degree of the edema part of the patient before and after treatment. ② the integral change of urine protein in 24 hours, urine volume in 24 hours and edema before and after treatment. Edema integration standard (1): 1 point, edema of the ankle and below; 2 min, anterior tibial edema, which is concave edema and does not indicate when pressing; 3 min, edema before shin, and press the finger of the physician's guiwei; 4, edema of both lower limbs and both upper limbs; 5min with serosal cavity fluid accumulation.

5. Evaluation criteria

The effect is shown: symptoms such as edema, hypodynamia and the like are obviously improved, the urine protein content is obviously reduced, the urine volume is obviously increased, and the edema integral is reduced by more than 70 percent compared with that before treatment; the method has the following advantages: symptoms such as edema, hypodynamia and the like are improved, the urine protein content is reduced, the urine volume is increased, and the edema integral is reduced by 30 to 70 percent compared with that before treatment; and (4) invalidation: the symptoms of edema, hypodynamia and the like, urine volume and urine protein are not changed, and the edema integral is reduced by less than 30 percent compared with that before treatment. The effective and effective sum is the total effective.

6. Statistical analysis data were analyzed using SPSS 19.0 statistical software.

7. Results

7.1 comparison of urine protein 24 hours, urine volume 24 hours, edema score before and after treatment (Table 1).

TABLE 2 comparison of the 24-hour urine protein, 24-hour urine volume, edema integral before and after treatment

Note: comparison with pre-treatment:^*P<0.05; compared with the treatment group⁺P<0.05。

As can be seen from Table 2, after the medicine of the present invention is used, the urine volume at 24 hours is significantly increased compared with that before the treatment, and the urine protein and edema scores at 24 hours are both significantly reduced compared with that before the treatment.

7.2 therapeutic comparison

After treatment, statistics were taken for the cure, and the results are shown in table 3.

TABLE 3 statistics of healing

As can be seen from Table 3, the medicine of the present invention can treat intractable renal edema with a definite therapeutic effect.

Typical cases

Liu Jie, female, age 38, was diagnosed with nephrotic syndrome, edema of both lower extremities, difficult recovery of depression, abdominal distension, anorexia, ascites (+) oliguria, yellow color (urine volume 500ml/24h or so), and conventional: PRO + + +, RBC5-8/HP,24h urine protein 4.2 g/L. After diuresis (furosemide 120mg/d) and 5-day edema aggravated by day, the urine volume is not obviously increased, 5 days after the prednisone acetate tablet is orally taken (55mg/d), on the basis of the treatment, the symptoms are improved after the medicament (prepared according to the example 1) is used for treating for 5 days, the urine volume is increased to 1400-1800 ml/d, the symptoms are completely recovered after the medicament is continuously used for 15 days, and the conventional urination is rechecked: PRO (+),24h urine protein 2.11 g/L. Follow-up 1 time per week for 6 months with no recurrence.

Wangzhi, male, age 29, was diagnosed with diabetic nephropathy, edema in the lower back, inability to rise with pressure, decreased urine volume (about 400 ml/d), abdominal distension, nausea, and urinary regularity: PRO + +, BLD +, 3.05g/L of 24h urine protein, taking benazepril hydrochloride 10mgBid for lowering blood pressure, and 30R insulin for subcutaneous injection 12u in the morning and 16u in the evening, and taking the traditional Chinese medicine orally and gradually adding furosemide to 140mg/d for intravenous drip without obvious relief. After 5 days of basic treatment with the drug of the invention (prepared as in example 1), the improvement is obvious, the urine volume is increased to about 1000ml/d, the edema is obviously resolved after the drug is continuously used for 10 days, only slight edema is generated in front of shins of both lower limbs, the urine volume reaches 2100ml/d, the uncomfortable symptoms disappear, and the urine routine is rechecked: PRO (+),24h urine protein 2.03 g/L. The disease was stable following 1 visit weekly for 6 months. .

Liu Jie, male, 25 years old, was diagnosed with chronic nephritis, depressed edema from both lower limbs to the root of the thigh, palpable ungual, lassitude of the limbs, decreased urine volume (600 + 800ml/24h), urinary convention: PRO + + +, BLD +, 3.3g/L of 24h urine protein, benazepril hydrochloride 10mg Qd for lowering blood pressure by oral administration, and the condition of the oral administration of the traditional Chinese medicine and the intravenous drip of furosemide from 80 mg/time to 140mg/d is not obviously relieved. On the basis of the basic treatment, after 5 days of using the medicament (prepared according to the example 1), the urine volume is obviously improved, the urine volume is increased to about 1100ml/d, the edema is obviously resolved after the medicament is continuously used for 10 days, only the mild edema in front of the shin of the lower limb is achieved, the urine volume reaches 2000-dose 2300ml/d, the uncomfortable symptoms disappear, and the urine routine is rechecked: PRO (+),24h urine protein 1.83 g/L. The disease was stable following 1 visit weekly for 6 months.

Compared with the prior art, the traditional Chinese medicine composition is prepared from cassia twig, white paeony root, ginger, fennel, ligusticum wallichii, asarum, earthworm, dried ginger and Chinese yam, has good synergistic function of the raw materials, is compatible in the whole formula, has the efficacy of promoting diuresis and reducing edema, can be used for treating intractable renal edema, is good in curative effect, has no drug resistance and side effects, and achieves the purpose of the invention.

The invention is further illustrated by the following examples, which are not to be construed as limiting the invention.

The specific implementation mode is as follows:

example 1.

The formula is as follows: 240g of cassia twig, 300g of white paeony root, 120g of ginger, 80g of fennel, 100g of ligusticum wallichii, 60g of asarum, 100g of earthworm, 150g of dried ginger and 150g of Chinese yam.

The process comprises the following steps: drying the above materials, and pulverizing into fine particles to obtain powder.

The usage and dosage are as follows: concocting the above medicinal powder with 45-55 deg.C warm water to obtain paste, applying the concocted medicinal powder on gauze, applying the gauze on edema part of patient, baking with infrared lamp for 20-30min, and standing for 5-10min until the residual temperature is removed. 1-2 times daily. The treatment course is 7-10 days.

Example 2.

The formula is as follows: 260g of cassia twig, 310g of white paeony root, 130g of ginger, 90g of fennel, 110g of ligusticum wallichii, 70g of asarum, 110g of earthworm, 160g of dried ginger and 160g of Chinese yam.

The process comprises the following steps: the method comprises the following steps:

(1) extracting the above materials with 6 times of 70% ethanol under reflux for 2 times, each for 1 hr, filtering the extractive solution, recovering ethanol from the filtrate, and concentrating to obtain extract with relative density of 1.10-1.12 at 50-60 deg.C to obtain product A;

(2) adding sorbitol 4% and glycerol 4% into product A, and heating to 85-90 deg.C for dissolving to obtain product B;

(3) heating stearic acid 6%, stearic acid 5%, yellow vaseline 2%, polysorbate 80 6%, lanolin 1% and sucrose stearate 1% to 85-90 deg.C, and melting to obtain product C;

(4) mixing the product B and the product C, emulsifying for 25 min, keeping the temperature at 60-70 deg.C for 55 min, adding 0.4% benzoic acid and 0.15% ethylparaben, mixing, and packaging to obtain ointment.

The usage and dosage are as follows: it is applied topically to affected parts, and is applied once every 4-6 h.

Example 3.

The formula is as follows: 220g of cassia twig, 290g of white paeony root, 110g of ginger, 70g of fennel, 90g of ligusticum wallichii, 50g of asarum, 90g of earthworm, 140g of dried ginger and 140g of Chinese yam.

(2) heating and melting rubber 35 wt%, rosin 35 wt%, vaseline 5 wt% and lanolin 15 wt% to obtain product B;

(3) adding the product B into the product A, mixing with glycerol 6 wt% and zinc oxide 40 wt% of the product B, stirring for 23 min to obtain medicinal material, respectively placing backing material, medical polyester film and medicinal material into patch coating equipment, grinding, shaping, cutting, packaging, sealing, and packaging to obtain patch.

Claims

1. A medicament for treating refractory renal edema, which is characterized in that: calculated by weight portion, the medicine is prepared by 260 portions of 220-reservoir cassia twig, 310 portions of 290-reservoir white paeony root, 130 portions of 110-reservoir ginger, 70-90 portions of fennel, 90-110 portions of szechuan lovage rhizome, 50-70 portions of manchurian wildginger, 90-110 portions of earthworm, 160 portions of 140-reservoir dried ginger and 160 portions of 140-reservoir Chinese yam.

2. The medicament for treating refractory renal edema as in claim 1, wherein: the traditional Chinese medicine composition is prepared from 240 parts by weight of cassia twig, 300 parts by weight of white paeony root, 120 parts by weight of ginger, 80 parts by weight of fennel, 100 parts by weight of szechuan lovage rhizome, 60 parts by weight of asarum, 100 parts by weight of earthworm, 150 parts by weight of dried ginger and 150 parts by weight of Chinese yam.

3. A method of making a medicament for treating refractory renal edema as in claim 1 or 2, wherein: mixing the above materials, adding adjuvants or not, processing according to conventional process, and making into pharmaceutical preparation.

4. A method of making a medicament for treating refractory renal edema as in claim 3, wherein: the pharmaceutical preparation is an external preparation.

5. The method of claim 4, wherein the method comprises the steps of: the external preparation is powder, ointment, patch, tincture, spray or gel.

6. The method of preparing a medicament for treating refractory renal edema as in claim 5, wherein: the preparation method of the powder comprises the following steps: drying the above materials, and pulverizing into fine particles.

7. The method of claim 5, wherein the method further comprises the step of: the preparation method of the ointment comprises the following steps:

8. The method of claim 5, wherein the method further comprises the step of: the preparation method of the patch comprises the following steps:

(3) adding the product B into the product A, mixing with 5-8 wt% of glycerol and 30-50 wt% of zinc oxide, stirring for 15-30 min to obtain medicinal materials, respectively placing backing material, medical polyester film and medicinal materials into patch coating equipment, grinding, forming, cutting, packaging, sealing, and packaging.

9. The method of claim 5, wherein the method further comprises the step of: the preparation method of the tincture comprises the following steps: weighing the raw materials according to the proportion of the prescription, adding 8-12 times of white spirit, and soaking for more than 30 days to obtain the traditional Chinese medicine.