CN109106918A - 一种治疗风湿骨病的中药及其制备方法 - Google Patents
一种治疗风湿骨病的中药及其制备方法 Download PDFInfo
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- CN109106918A CN109106918A CN201811323099.3A CN201811323099A CN109106918A CN 109106918 A CN109106918 A CN 109106918A CN 201811323099 A CN201811323099 A CN 201811323099A CN 109106918 A CN109106918 A CN 109106918A
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- radix
- rhizoma
- bone disease
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- rheumatism bone
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Abstract
本发明涉及中药领域,特别涉及一种治疗风湿骨病的中药及其制备方法。由以下原料制成:丹参、三七粉、红花、怀牛膝、骨碎补、土鳖虫、防风、五加皮、独活、伸筋草、秦艽、防已、川芎、延胡索、郁金、天麻、蝎子、地龙、赤芍、生地黄、桂枝、葛根、柏子仁、合欢皮、当归、熟地黄、何首乌、续断龟甲、黄精、西洋参、人参、生黄芪、白术、知母、决明子、天花粉、茯苓、薏苡仁、泽泻、黄芩、大黄。本发明中药配伍运用君,臣,佐,使配伍原则,具有祛风除湿,散寒止痛,活血化瘀,祛风除痹,利水消肿,舒筋活络,的功效,对风湿骨病有良好的疗效。
Description
技术领域
本发明涉及中药领域,特别涉及一种治疗风湿骨病的中药及其制备方法。
背景技术
风湿骨病主要是由于风寒引起的血液循环不通畅,致使包括肌、韧带、滑囊、筋膜的营养供给不良导致的疾病。关节病变除有疼痛外尚伴有肿胀和活动障碍,呈发作与缓解交替的慢性病程,部分患者且可出现关节致残和内脏功能衰竭。初发时起病缓慢,患者先是几周内到几个月的疲倦乏力,体重减轻、胃纳不佳、低热和手足麻木刺痛等前驱症状。随后发生关节疼痛、僵硬、肿大周围皮肤温热、潮红自动和被动运动都引起疼痛。开始一、二个关节受累,往往是游走性。以后发展为对称性多关节炎从四肢远端的小关节开始再累及其它关节。其次为掌指、趾、腕、膝、肘、踝、肩和髋关节等,晨间关节僵硬,肌肉酸痛。随着风湿、类风湿关节炎病变的发展,患者不规则发热,脉搏加快,显著贫血,关节成僵硬而畸形,导致残废。膝、肘、手指、腕部成固定屈位,手指向外侧成半脱位,患者失去生活自理能力,终日不离床褥,不能动弹而极度痛苦。
目前,大部分风湿骨病还不能根治。在治疗手段方面,西医主要是通过药物来消除急性发热、发炎、疼痛等症状,但是,这些药物大多数对人体的重要器官以及组织会有不同的毒性作用。中医治疗风湿骨病一般以“祛邪、通络、止痛”为基本原则,或以温经通络、或以活血通络,再辅以健脾、补肾、理气等治疗手段;散寒、祛风、除湿、通经活络;其常用的中成药有:风湿关节炎片、腰痛宁胶囊、追风透骨丸、疏风定痛丸、小活络丹、宝光风湿液、风湿骨痛丸、骨刺消痛液等。
由于风湿骨病的病程长,病情反复大,给患者带来极大痛苦。目前,市场上有各种治疗风湿骨痛的中西药,影响患者的肠胃健康且有一定的不适感和副作用,导致临床效果不理想。
发明内容
本发明提供了一种治疗风湿骨病的中药及其制备方法。
为实现上述目的,本发明采用技术方案为:
一种治疗风湿骨病的中药,由以下原料组成:丹参5-15g、三七粉3-10g、红花3-10g、怀牛膝8-15g、骨碎补8-15g、土鳖虫3-10g、防风3-10g、五加皮5-15g、独活3-10g、伸筋草8-15g、秦艽3-10g、防已5-10g、川芎3-10g、延胡索5-15g、郁金8-15g、天麻8-15g、蝎子5-15g、地龙3-10g、赤芍3-10g、生地黄5-15g、桂枝3-10g、葛根3-10g、柏子仁5-15g、合欢皮5-15g、当归3-10g、熟地黄5-15g、何首乌8-15g、续断5-15g、龟甲5-15g、黄精5-15g、西洋参5-15g、人参5-15g、生黄芪5-15g、白术3-10g、知母3-10g、决明子5-15g、天花粉3-10g、茯苓5-15g、薏苡仁5-15g、泽泻8-15g、黄芩3-10g、大黄3-10g。
优选的,丹参15g、三七粉5g、红花5g、怀牛膝10g、骨碎补10g、土鳖虫5g、防风5g、五加皮15g、独活5g、伸筋草10g、秦艽5g、防已5g、川芎5g、延胡索15g、郁金10g、天麻10g、蝎子15g、地龙5g、赤芍5g、生地黄15g、桂枝5g、葛根5g、柏子仁15g、合欢皮15g、当归5g、熟地黄15g、何首乌10g、续断15g、龟甲15g、黄精15g、西洋参15g、人参15g、生黄芪15g、白术5g、知母5g、决明子15g、天花粉5g、茯苓15g、薏苡仁15g、泽泻10g、黄芩5g、大黄5g。
所述的治疗风湿骨病的中药的制备方法为按上述比例将原料混合,而后将混合药物加入到25-30kg酒中浸泡,制备得中药酒。浸泡1-3个月,可以服用,浸泡时间越长,药酒的治疗效果更明显。
或者将中药分别研磨至粉末,而后按上述比例混合,过200目筛后加入到25kg-30kg的蜂蜜中,加热温度小于50℃,加热并搅拌3-5min,制备得中药膏。由于蜂蜜中含有多种人体代谢中起重要作用的酶,如葡萄糖转化酶、蔗糖酶、淀粉酶等。这些酶类都怕热,温度升高,就失去活性,营养价值消失。另外,蜂蜜中的维生紊、氨基酸等营养成分也都怕热,高温会使之受到破坏,因此,蜂蜜加热时不超过50℃。
所述中药用于治疗风湿骨病。
所述风湿骨病包括但不限于风湿病、骨质增生、座骨神经、关节炎、肩周炎、腰椎间盘突出症、关节肿胀、筋脉拘挛。
丹参,药味苦,性微寒,归心,心胞肝经。功能:活血祛瘀,养血安神,凉血消痛,活血化瘀。
三七粉,药味甘,微苦,性温,归肝胃经。功能:化淤止血,活血止痛。
红花,药味辛,微苦,性温,归心肝经。功能:活血通经,祛瘀止痛。
怀牛膝,药味酸苦,性平,归肝肾经。功能:活血通经,利关节,强腰膝,利尿通淋,引血,引火下行。
骨碎补,药味苦,性温,归肝肾经。功能:补肾续骨,活血止痛。土鳖虫,药味咸,性寒,有小毒,归肝经。
防风,药味辛甘,性微温,归膀胱,肺脾经。功能:解表,祛风胜湿,止痛止痉。
五加皮,药味辛苦,性温,归肝肾经。功能:祛风湿,补肝肾,强筋骨,活血脉,利水消肿。
独活,药味辛苦,性温,归肾,膀胱经。功能:祛风胜湿,散寒止痛。
伸筋草,药味辛苦,性温,归肝经。功能:祛风除湿,舒筋活络。
秦艽,药味苦辛,性微寒,归胃,肝,胆经。功能:祛风湿,舒筋络,退虚热。
防已,药味苦辛,性寒,归膀胱,肾,脾经。功能:祛风湿,止痹痛,利水消肿。
川芎,药味辛,性温,归肝,胆,心包经。功能:活血行气,祛风止痛。
延胡索,药味辛苦,性温,肝脾,心经。功能:活血散瘀,行气止痛。
郁金,药味辛苦,性寒,归心,肝,胆经。功能:活血止痛,行气解热,清热凉血,清心开窍。
天麻,药味甘辛,性平,归肝经。功能:平肝潜阳,熄风止痉,通经活络。
蝎子,药味辛咸,性平,有毒,归肝经。功能:熄风止痉,通络止痛,解毒散结。
地龙,药味咸,性寒,归肝,肺,肾经。功能:清热平肝,熄风止痉,平喘利水通经。
赤芍,药味酸苦,性微寒,归肝,脾经。功能:清热凉血,活血祛瘀,清泄肝火。
生地黄,药味甘,微苦,性凉,归心,肝,肾经。功能:清热凉血,养阴生律。
桂枝,药味辛甘,性温,归心,肺,膀胱经。功能:散寒解表,温通经脉,通阳化气。
葛根,药味甘辛,性平,归脾,胃经。功能:解肌退热,透发麻疹,生津止渴,升阳止泻。
柏子仁,药味甘,性平,归心肾,大肠经。功能:养心安神,敛汗,润肠通便。
合欢皮,药味甘,性平,归心肝经。功能:安神解郁,活血消痈。
当归,药味甘,辛,性温,归肝,心,脾经。功能:补血调经,活血止痛,润肠通便。
熟地黄,药味甘,性微温,归肝,肾经。功能:补血滋阴,填精益髓。
何首乌:药味苦、甘、涩,性微温,归肝、肾心经。功能:补益肝肾,滋养精血,养心宁神,润肠通便,解毒散结。
续断:药味辛,性微温,归肝、肾经。功能:补肝肾,壮筋骨,通关节和血脉,止血。
龟甲,药味咸,甘,性微寒,归肝,肾,心经。功能:滋阴潜阳,益肾健骨,逐瘀续筋,养血止血,解毒敛疮。
黄精,药味甘,性平,归肺,脾,肾经。功能:补脾益气,润脉生津。补肾填精,杀虫。
西洋参,药味甘,微苦,性凉,归肺,心,肾经。功能:补气养阴,清火生津。
人参,药味甘,微苦,性微温,归脾,肺,心,肾经。功能:大补元气,健脾益肺,生津止渴,安神益智。
生黄芪,药味甘,性微温,归肺,脾二经。功能:益气固表,利水消肿,托毒生肌。
白术,药味甘,苦,性温,归脾,胃之经。功能:健脾益气,燥湿利水,固表止汗。
知母,药味苦,甘,性寒,归肺,胃,肾经。功能:清热泻火,滋阴润燥。
决明子,药味苦,甘,咸,性微寒,归肝,肾,大肠经。功能:清肝明目,平肝潜阳,润肠通便。
天花粉,药味微甘,微苦酸,性微寒,归肺,胃经。功能:清热生津,润肺化痰,消肿排脓。
茯苓,药味甘,淡,性平,归心,肺,脾,肾经。功能:利水渗湿,健脾和中,宁心安神。
薏苡仁,药味甘,淡,性微寒,归脾,胃,肺经。功能:利湿健脾,舒筋除痹,清热排脓。
泽泻,药味甘,淡,性寒,归肾,膀胱经。功能:利水渗湿,泄热降脂。
黄芩,药味苦,性寒,归心肺,胆,大肠经。功能:清热燥湿,泻火解毒,止血。
大黄,药味苦,性寒,归胃,大肠,肝经。功能:通便导滞,泻火解毒,逐瘀通经,止血。
防风、五加皮、独活、伸筋草、秦艽、防已、天麻、蝎子、地龙、葛根为君药;君药具有祛风散寒、祛风除痹、祛风胜湿、舒筋活络、补益肝肾的功效。丹参、三七粉、红花、怀牛膝、骨碎补、土鳖虫、川芎、延胡索、郁金为臣药;臣药用于活血化瘀,去骨刺。当归、熟地黄、龟甲、黄精、西洋参、人参、白术、续断、何首乌作为佐药;佐药作为补药,具有补肾、补血、补精的作用。知母、决明子、天花粉、茯苓、泽泻、黄芩、大黄作为使药;使药具有清热解毒去火的作用。
本发明的有益效果:
1)本发明利用驱邪法,根据因感受风寒湿等外邪的偏盛和病症采取的清热解毒、祛风除湿散寒的治疗方法。
2)本发明中药配伍运用君臣佐使配伍原则,以温,凉,热,寒,补,泻,通合宜而共用的独特配方,为多味药配伍,具有祛风除湿,散寒止痛,活血化瘀,祛风除痹,利水消肿,舒筋活络,通关窍,促凝血,温经通脉,通阳化气,滋肾补血,填精益髓,清热解毒,泻火,抗菌,抗炎,抗病毒,抗肿瘤,增强机体免疫力的功效,对风湿骨病有良好的疗效。
3)本发明中药适用于风湿病,骨质增生,座骨神经,关节炎,肩周炎,腰椎间盘突出症,关节肿胀,筋脉拘挛等各类疾病,疗程短,见效快,疗效好,无毒副作用。
具体实施方式
实施例1
丹参15g、三七粉5g、红花5g、怀牛膝10g、骨碎补10g、土鳖虫5g、防风5g、五加皮15g、独活5g、伸筋草10g、秦艽5g、防已5g、川芎5g、延胡索15g、郁金10g、天麻10g、蝎子15g、地龙5g、赤芍5g、生地黄15g、桂枝5g、葛根5g、柏子仁15g、合欢皮15g、当归5g、熟地黄15g、何首乌10g、续断15g、龟甲15g、黄精15g、西洋参15g、人参15g、生黄芪15g、白术5g、知母5g、决明子15g、天花粉5g、茯苓15g、薏苡仁15g、泽泻10g、黄芩5g、大黄5g,按上述原料用量,将各中药混合后加入到25kg酒中浸泡,浸泡时间30天,制备得中药酒。
实施例2
丹参15g、三七粉10g、红花10g、怀牛膝15g、骨碎补10g、土鳖虫10g、防风10g、五加皮15g、独活10g、伸筋草15g、秦艽10g、防已5g、川芎10g、延胡索15g、郁金15g、天麻15g、蝎子15g、地龙10g、赤芍10g、生地黄15g、桂枝10g、葛根10g、柏子仁15g、合欢皮15g、当归10g、熟地黄15g、何首乌15g、续断15g、龟甲15g、黄精15g、西洋参15g、人参15g、生黄芪15g、白术10g、知母10g、决明子15g、天花粉10g、茯苓15g、薏苡仁15g、泽泻15g、黄芩10g、大黄10g,将各中药混合后加入到30kg酒中浸泡,浸泡时间60天,制备得中药酒。
实施例3
丹参15g、三七粉5g、红花5g、怀牛膝10g、骨碎补10g、土鳖虫5g、防风5g、五加皮15g、独活5g、伸筋草10g、秦艽5g、防已5g、川芎5g、延胡索15g、郁金10g、天麻10g、蝎子15g、地龙5g、赤芍5g、生地黄15g、桂枝5g、葛根5g、柏子仁15g、合欢皮15g、当归5g、熟地黄15g、何首乌10g、续断15g、龟甲15g、黄精15g、西洋参15g、人参15g、生黄芪15g、白术5g、知母5g、决明子15g、天花粉5g、茯苓15g、薏苡仁15g、泽泻10g、黄芩5g、大黄5g,将中药分别研磨至粉末混合,过200目筛后加入到25kg的蜂蜜中,加热温度30℃,加热并搅拌3min,制备得中药膏。
实施例4
丹参15g、三七粉10g、红花10g、怀牛膝15g、骨碎补10g、土鳖虫10g、防风10g、五加皮15g、独活10g、伸筋草15g、秦艽10g、防已5g、川芎10g、延胡索15g、郁金15g、天麻15g、蝎子15g、地龙10g、赤芍10g、生地黄15g、桂枝10g、葛根10g、柏子仁15g、合欢皮15g、当归10g、熟地黄15g、何首乌15g、续断15g、龟甲15g、黄精15g、西洋参15g、人参15g、生黄芪15g、白术10g、知母10g、决明子15g、天花粉10g、茯苓15g、薏苡仁15g、泽泻15g、黄芩10g、大黄10g,将中药分别研磨至粉末混合,过200目筛后加入到30kg的蜂蜜中,加热温度45℃,加热并搅拌5min,制备得中药膏。
临床病例
病例1
赵某,男,45岁,患风湿性关节炎,关节疼痛,红肿,活动受限,服用本发明实施例1中药酒,每日早晚各一次,每次20ml,1周后关节消肿疼痛减轻,2个疗程后治愈,可以自由活动。(1个疗程为30天)
病例2
王某,男,55岁,患坐骨神经滑膜炎,坐骨结节处疼痛,久坐后酸胀痛,服用本发明实施例1中药酒,每日早晚各一次,每次20ml,1周关节肿痛减轻,1个月明显效果,5个疗程治愈。(1个疗程为30天)
病例3
于某,女,40岁,腰椎间盘突出症,患病多年,腰部疼痛,双下肢麻木,服用本发明实施例2中药酒,每日早晚各一次,每次20ml,1周后腰椎部位疼痛减轻,1个月效果显著,2个疗程效果更佳,5个疗程治愈。(1个疗程为30天)
病例4
刘某,男,50岁,肩周炎,患病多年,肩关节周围胀痛,活动时加重,伴有上肢的麻木疼痛等症状,服用本发明实施例2的中药酒,每日早晚各一次,每次20ml,1个月症状疼痛减轻,3个疗程痊愈。(1个疗程为30天)
病例5
赵某,男,40岁,风湿,肢体疼痛麻木,服用本发明实施例3的中药膏,每日早晚各一次,每次20ml,加水冲调后服用,1周肢体疼痛减轻,活动自由,2周肢体疼痛减轻,3个疗程治愈。(1个疗程为30天)
病例6
张某,男,43岁,风湿,肾虚腰疼,腰肌劳损,水肿,关节疼痛,服用本发明实施例3的中药膏,每日早晚各一次,每次20ml,加水冲调后服用,1周肾虚腰疼症状好转,尿频尿急症状改善,关节疼痛减轻,1个月后效果显著,3个疗程效果更佳,水肿消失,腰腿疼痛消失,1年后治愈。(1个疗程为30天)
对比例
1、试用对象:各选择20名患有风湿骨病的患者进行试验,两组的20人中10人为45-55岁的患者,5人为58-70岁的患者,5人为75-85岁的患者。
2、使用方法:使用本发明制得的中药组合物,每天2次,每次20ml;用药3个疗程后询问使用效果。
3、判断标准:(1)显效:疼痛感消失,半年内无复发;(2)有效:与使用前相比有一定程度的改善;(3)无效:症状无变化。
本发明的实施例1的中药酒与座骨神经丸对风湿骨病的治疗效果的对比实施例1与座骨神经丸的疗效对比表,见表1。
表1
组别 | 临床人数 | 显效 | 有效 | 无效 |
实施例1 | 20 | 15 | 3 | 2 |
座骨神经丸 | 20 | 5 | 8 | 7 |
本发明的实施例1的中药酒与骨刺消痛液对风湿骨病的治疗效果的对比实施例1与骨刺消痛液的疗效对比表,见表2。
表2
组别 | 临床人数 | 显效 | 有效 | 无效 |
实施例1 | 20 | 16 | 2 | 1 |
骨刺消痛液 | 20 | 3 | 7 | 10 |
本发明的实施例2的中药酒与腰痛宁片对风湿骨病的治疗效果的对比实施例2与腰痛宁片的疗效对比表,见表3。
表3
组别 | 临床人数 | 显效 | 有效 | 无效 |
实施例1 | 20 | 18 | 1 | 1 |
腰痛宁片 | 20 | 2 | 9 | 9 |
从表1-3可知,本发明中药相比于现有药物的治疗效果更佳。
Claims (6)
1.一种治疗风湿骨病的中药,其特征在于:由以下原料组成:丹参5-15g、三七粉3-10g、红花3-10g、怀牛膝8-15g、骨碎补8-15g、土鳖虫3-10g、防风3-10g、五加皮5-15g、独活3-10g、伸筋草8-15g、秦艽3-10g、防已5-10g、川芎3-10g、延胡索5-15g、郁金8-15g、天麻8-15g、蝎子5-15g、地龙3-10g、赤芍3-10g、生地黄5-15g、桂枝3-10g、葛根3-10g、柏子仁5-15g、合欢皮5-15g、当归3-10g、熟地黄5-15g、何首乌8-15g、续断5-15g、龟甲5-15g、黄精5-15g、西洋参5-15g、人参5-15g、生黄芪5-15g、白术3-10g、知母3-10g、决明子5-15g、天花粉3-10g、茯苓5-15g、薏苡仁5-15g、泽泻8-15g、黄芩3-10g、大黄3-10g。
2.按权利要求1所述的治疗风湿骨病的中药,其特征在于:由以下原料制成:丹参15g、三七粉5g、红花5g、怀牛膝10g、骨碎补10g、土鳖虫5g、防风5g、五加皮15g、独活5g、伸筋草10g、秦艽5g、防已5g、川芎5g、延胡索15g、郁金10g、天麻10g、蝎子15g、地龙5g、赤芍5g、生地黄15g、桂枝5g、葛根5g、柏子仁15g、合欢皮15g、当归5g、熟地黄15g、何首乌10g、续断15g、龟甲15g、黄精15g、西洋参15g、人参15g、生黄芪15g、白术5g、知母5g、决明子15g、天花粉5g、茯苓15g、薏苡仁15g、泽泻10g、黄芩5g、大黄5g。
3.一种权利要求1或2所述的治疗风湿骨病的中药的制备方法,其特征在于:按上述比例将原料混合,而后将混合药物加入到25-30kg酒中浸泡,制备得中药酒。
4.一种权利要求1或2所述的治疗风湿骨病的中药的制备方法,其特征在于:将中药分别研磨至粉末,而后按上述比例混合,过200目筛后加入到25kg-30kg的蜂蜜中,加热温度小于50℃,加热并搅拌3-5min,制备得中药膏。
5.一种权利要求1或2中所述的治疗风湿骨病的中药的应用,其特征在于:所述中药用于治疗风湿骨病。
6.按权利要求5所述的治疗风湿骨病的中药的应用,其特征在于:所述风湿骨病包括但不限于风湿病、骨质增生、座骨神经、关节炎、肩周炎、腰椎间盘突出症、关节肿胀、筋脉拘挛。
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