CN109106886A - A kind of pharmaceutical composition, Preparation method and use - Google Patents
A kind of pharmaceutical composition, Preparation method and use Download PDFInfo
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- CN109106886A CN109106886A CN201811204934.1A CN201811204934A CN109106886A CN 109106886 A CN109106886 A CN 109106886A CN 201811204934 A CN201811204934 A CN 201811204934A CN 109106886 A CN109106886 A CN 109106886A
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- endothelium corneum
- gigeriae galli
- corneum gigeriae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/57—Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/58—Reptiles
- A61K35/586—Turtles; Tortoises, e.g. terrapins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
- A61K35/644—Beeswax; Propolis; Royal jelly; Honey
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8998—Hordeum (barley)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The present invention provides a kind of pharmaceutical compositions, Preparation method and use.Pharmaceutical composition includes the bulk pharmaceutical chemicals of following parts by weight: 6~12 parts of rhizoma atractylodis, 10~20 parts of Poria cocos, 10~20 parts of endothelium corneum gigeriae galli, 3~6 parts of Radix picrorrhizae, 8~16 parts of dark plum, simmer 4~8 parts of betel nut, 10~20 parts of charred FRUCTUS CRATAEGI, 6~12 parts of Fructus Aurantii, 10~20 parts of Massa Medicata Fermentata preparata, 10~20 parts of coloured malt, 6~12 parts+beneficial effect of radix glycyrrhizae preparata.With fortune spleen appetizing, promoting digestion.The indigestion and loss of appetite deficiency of food being particularly suitable for caused by pediatric diet does not save, abdominal fullness and distention, feverishness in palms and soles, uncomfortable, anorexia of defecating dislike the good effect of food.
Description
Technical field
The present invention relates to field of traditional Chinese medicine preparations, in particular to a kind of external application pellet medicine, preparation method and applications.
Background technique
Today's society, living condition is superior, and various high heat, high nutrition, the deep fried foodstuff that stirs fry in oil are more, " feeding child " at
The major issue of each family, parent is for the love to child, and covet high nutrition, it has been reported that " having kind and starving and cry ' your mother's feel
You is obtained not have enough ' ".Children's " asthenic susceptibility of spleen ", spleen and stomach function is weak, and the product food of greasy savoury is difficult to digest, long easy formation
Dyspepsia.
Dyspepsia is to stop long-pending stomach because of children's improper feeding, internal damage caused by infantile dyspepsia, and spleen transports a kind of spleen that children are common caused by mistake department
Stomach trouble card.Clinic is eaten without digesting with do not feel like eating, and abdominal distension is rotten, and sour smelly or constipation of defecating is characterized.The healthy growth of children,
The various nutriments depended in diet moisten, but if unilateral increase high heat, high nutrition, effect will run counter to desire, often
Make spleen and stomach function impaired because of infantile dyspeptic gastroenteropathy, becomes the pathogenic factor of a variety of diseases of children, the pathologic basis such as infantile indigestion with food retention is normal
The diseases such as Chang Yihui causes vomiting, abdominal pain, diarrhea, fever, anorexia, stagnant, infantile malnutrition can seriously affect children's health and just
Often development.
Summary of the invention
In view of this, the purpose of the present invention is to provide a kind of pharmaceutical composition, Preparation method and use, to treat product
Food.
In a first aspect, the embodiment of the invention provides a kind of pharmaceutical compositions characterized by comprising rhizoma atractylodis 6~12
Part, 10~20 parts of Poria cocos, 10~20 parts of endothelium corneum gigeriae galli, 3~6 parts of Radix picrorrhizae, 8~16 parts of dark plum, 4~8 parts of betel nut are simmered, charred FRUCTUS CRATAEGI
10~20 parts, 6~12 parts of Fructus Aurantii, 10~20 parts of Massa Medicata Fermentata preparata, 10~20 parts of coloured malt, 6~12 parts of radix glycyrrhizae preparata.
With reference to first aspect, the embodiment of the invention provides the first possible embodiments of first aspect, wherein also
Include:
Further include: 10-20 parts and honey 20-30 parts of turtle shell rubber powder.
With reference to first aspect, the embodiment of the invention provides second of possible embodiments of first aspect, wherein institute
State pharmaceutical composition, comprising: 6 parts of rhizoma atractylodis, 10 parts of Poria cocos, 10 parts of endothelium corneum gigeriae galli, 3 parts of Radix picrorrhizae, 8 parts of dark plum, simmer 4 parts of betel nut, coke
10 parts of hawthorn, 6 parts of Fructus Aurantii, 10 parts of Massa Medicata Fermentata preparata, 10 parts of coloured malt, 6 parts of radix glycyrrhizae preparata.
The possible embodiment of second with reference to first aspect, the embodiment of the invention provides the third of first aspect
Possible embodiment, wherein described pharmaceutical composition, further includes: 10 parts and 20 parts of honey of turtle shell rubber powder.
Second aspect, it is possible according to the third of first aspect to first aspect that the embodiment of the invention also provides a kind of
The drug that any Chinese medicine composition is prepared in embodiment.
In conjunction with second aspect, the embodiment of the invention provides the first possible embodiments of second aspect, wherein institute
The dosage form of drug is stated as any one in decoction, pill, powder, capsule, leaching agent, paste or spray.
The third aspect, the embodiment of the invention provides a kind of such as second aspect or second aspect the first possible implementation
The preparation method of drug described in mode, includes the following steps:
Step 1: endothelium corneum gigeriae galli bakes, pulverized powder sieves with 100 mesh sieve hole, obtains endothelium corneum gigeriae galli powder；
Step 2: remaining medicine impregnates 12 hours, high pressure boiling machine is decocted the medicine for three times, and is merged medical fluid, is staticly settled, then with 4 layers of nothing
It bacterium filtered through gauze 3 times, is then concentrated by evaporation, is allowed to gradually into thick shape with 90 DEG C；
Step 3: admixing endothelium corneum gigeriae galli powder.
Fourth aspect, the embodiment of the invention provides a kind of such as first aspect to first aspect the third possible embodiment party
It is indigestion and loss of appetite deficiency of food of any Chinese medicine composition caused by preparing Therapeutic diet and not saving in formula, abdominal fullness and distention, feverishness in palms and soles, big
Just uncomfortable, anorexia, evil eat the purposes in the drug of illness.
The present invention has the positive effect that:
Transport spleen appetizing, promoting digestion.It is particularly suitable for pediatric diet and does not save caused indigestion and loss of appetite deficiency of food, abdominal fullness and distention, brothers
Heart heat, uncomfortable, anorexia of defecating, dislikes food.
To enable the above objects, features and advantages of the present invention to be clearer and more comprehensible, preferred embodiment is cited below particularly, and cooperate
Institute's embodiment, is described in detail below.
Specific embodiment
In order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below in conjunction with the embodiment of the present invention,
Technical scheme in the embodiment of the invention is clearly and completely described, it is clear that described embodiment is only the present invention
A part of the embodiment, instead of all the embodiments.The embodiment of the present invention described and illustrated in usual embodiment here
Component can be arranged and be designed with a variety of different configurations.Therefore, the implementation of the invention to providing in embodiment below
The detailed description of example is not intended to limit the range of claimed invention, but is merely representative of selected implementation of the invention
Example.Based on the embodiment of the present invention, those skilled in the art are obtained all without making creative work
Other embodiments shall fall within the protection scope of the present invention.
The present invention provides a kind of pharmaceutical composition, the bulk pharmaceutical chemicals including following parts by weight: 6~12 parts of rhizoma atractylodis, Poria cocos 10
~20 parts, 10~20 parts of endothelium corneum gigeriae galli, 3~6 parts of Radix picrorrhizae, 8~16 parts of dark plum, 4~8 parts of betel nut of stewing, 10~20 parts of charred FRUCTUS CRATAEGI, trifoliate orange
6~12 parts of shell, 10~20 parts of Massa Medicata Fermentata preparata, 10~20 parts of coloured malt, 6~12 parts of radix glycyrrhizae preparata.
In the present invention, according to parts by weight, the typical but non-limiting number of rhizoma atractylodis is for example are as follows: 6 parts, 7.2 parts, 8.4
Part, 9.6 parts, 10.8 parts or 12 parts.
Rhizoma atractylodis acrid, bitter, warm, the diverging of this product pungent-warm, bitter dry dehumidifying enter taste warp, both eliminating dampness and invigorating the spleen, be damp retention in middle-jiao it
Key medicine.
In the present invention, according to parts by weight, the typical but non-limiting number of Poria cocos is for example are as follows: 10 parts, 12 parts, 14 parts,
16 parts, 18 parts or 20 parts.
Poria cocos nature and flavor are sweet, light, flat, return heart, spleen, kidney channel.Effect clearing damp and promoting diuresis, invigorating the spleen are calmed the nerves.
In the present invention, according to parts by weight, the typical but non-limiting number of Radix picrorrhizae is for example are as follows: 3 parts, 3.5 parts, 4
Part, 4.5 parts, 5 parts, 5.5 parts or 6 parts.
Radix picrorrhizae is bitter, cold, return heart, liver, stomach, large intestine channel, and bitter cold is dry clearly, above enter the heart channel of Hang-Shaoyin, in enter stomach meridian, under walk liver and big
Intestines warp, not only clearind deficient heat, treating infantile malnutrition wide fever, but also clearing away damp-heat, relieving heat toxin are abnormal heat, the product of real heat two clearly.
In the present invention, according to parts by weight, the typical but non-limiting number of dark plum is for example are as follows: 8 parts, 9.3 parts, 10.6
Part, 11.9 parts, 13.2 parts, 14.5 parts or 16 parts.
Dark plum acid is flat, and acid puckery can be held back, and puts down without inclined, had not only entered liver, the spleen channel, but also enter lung and large intestine channel.Upper energy astringing lung-QI gas is with only
Cough, the lower puckery large intestine of energy can be restrained with antidiarrheal to stop blooding, and because tart flavour solely weighs, and also kind claming ascaris promotes the production of body fluid.
In the present invention, according to parts by weight, the typical but non-limiting number of betel nut is simmered for example are as follows: 4 parts, 4.6 parts, 5.2
Part, 5.8 parts, 6.4 parts, 7.2 parts or 8 parts.
It is bitter in taste, pungent, warm to simmer betel nut, returns spleen, stomach, large intestine channel.Effect disperse accumulation promoting the circulation of qi, expelling parasite Li Shui.For QI stagnating in middle-JIAO,
Milk inner buildup, and a variety of worm diseases.Effect is killed to a variety of helminths such as tapeworm, hookworm, roundworm, burning worm, fasciolopsis.This product
Pungent scattered hardship is let out, can gas consumption product and laxative and defaecation, to stagnation of QI due to dyspepsia, abdominal distention, rotten acid regurgitation is defecated not well.
In the present invention, according to parts by weight, the typical but non-limiting number of charred FRUCTUS CRATAEGI is for example are as follows: 10 parts, 12 parts, 14
Part, 16 parts, 18 parts or 20 parts.
Charred FRUCTUS CRATAEGI nature and flavor are sour, sweet, tepor, returns spleen, stomach, Liver Channel.Effect, which helps digestion, helps fortune, changes the scattered stasis of blood of product.Compendium of Material Medica cloud
" changing diet, the meat accumulation that disappears, mausoleum addiction, phlegm retention, feeling of fullness acid regurgitation, stagnant blood distending pain ".Strong, meat stagnation card is lost for spleen fortune.This product has fortune
The function of spleen disperse accumulation especially digests the key medicine of greasy meat.The institute's abdomen turgor of all meat dyspepsias, heating acid regurgitation, abdominal pain just do not ward off person,
Decoction is applied alone effectively, or is equally used with Lay trip, Divine Comedy.
In the present invention, according to parts by weight, the typical but non-limiting number of Fructus Aurantii is for example are as follows: 6 parts, 7.2 parts, 8.4
Part, 9.6 parts, 10.8 parts or 12 parts.
Fructus Aurantii is bitter, pungent, slightly cold, and hardship is let out row and dissipated, slightly cold not strong, enters spleen, stomach and large intestine channel, kind regulating the flow of QI to ease the stomach and row is stagnant removes
It is swollen.
In the present invention, according to parts by weight, the typical but non-limiting number of Massa Medicata Fermentata preparata is for example are as follows: 10 parts, 12 parts, 14
Part, 16 parts, 18 parts or 20 parts.
Massa Medicata Fermentata preparata is sweet, pungent, warm, returns spleen stomach meridian, and in Gan Wenli, Xin Xiang row dissipates, main digestion gathered food, and promoting the circulation of qi is stagnant.
In the present invention, according to parts by weight, the typical but non-limiting number of coloured malt is for example are as follows: 10 parts, 12 parts, 14
Part, 16 parts, 18 parts or 20 parts.
Coloured malt is sweet, flat, returns spleen, stomach, Liver Channel, food digesting stomach fortifying, the stagnant person of outstanding preferably rice, face, potato etc..
In the present invention, according to parts by weight, the typical but non-limiting number of radix glycyrrhizae preparata is for example are as follows: 6 parts, 7.2 parts, 8.4
Part, 9.6 parts, 10.8 parts or 12 parts.
Radix glycyrrhizae preparata is to make medicine, invigorating middle warmer and replenishing QI, relieving spasm to stop pain, and mitigates pharmacological property.Fortune spleen appetizing is played altogether by full side, promoting digestion it
Function.
Charred FRUCTUS CRATAEGI, Massa Medicata Fermentata preparata, three medicine digestion-promoting spleen-invigorating of coloured malt help fortune, change product, and disappear all eating accumulation (carnivorous greasy, paddy
Face etc.) it is monarch.The sweet flat dissipation of endothelium corneum gigeriae galli enters taste warp, is apt to fortune spleen stomach invigorating, promoting digestion and removing indigestion, helps three celestial beings, transports spleen to help digestion；It simmers
The promoting the circulation of qi of betel nut disperse accumulation, laxative defaecation；Fructus Aurantii regulating the flow of QI to ease the stomach and the stagnant de-swelling of row；Poria cocos clearing damp and promoting diuresis, spleen-benefiting mind-tranquilizing, rhizoma atractylodis eliminating dampness are strong
Spleen is ministerial drug altogether.Both clearind deficient heat, treating infantile malnutrition wide fever, clearing away damp-heat, relieving heat toxin, the puckery intestines of dark plum promote the production of body fluid Radix picrorrhizae, and the two is adjutant altogether.
From the point of view of modern related pharmacological research, the peptic effect of hawthorn, malt, Divine Comedy.Betel nut expelling parasites and food tagnancy, row
Gas Li Shui, arecaline have quasi- choline to act on, excited choline receptor, promotion saliva, sweat gland secretion, increase enterocinesia, reducing heart rate,
The effects of reducing blood pressure.Fructus Aurantii can make gastrointestinal motility shrink rhythm and pace of moving things increase, there is enhancing intestinal smooth muscle tensity and position phasic property
Contractile function.Radix picrorrhizae has liver protection, cholagogue, antifungic action.
As a preferred embodiment of the present invention, according to parts by weight include following raw material: 6~12 parts of rhizoma atractylodis, Poria cocos 10
~20 parts, 10~20 parts of endothelium corneum gigeriae galli, 3~6 parts of Radix picrorrhizae, 8~16 parts of dark plum, 4~8 parts of betel nut of stewing, 10~20 parts of charred FRUCTUS CRATAEGI, trifoliate orange
6~12 parts of shell, 10~20 parts of Massa Medicata Fermentata preparata, 10~20 parts of coloured malt, 6~12 parts of radix glycyrrhizae preparata, 10-20 parts of turtle shell rubber powder and honey
20-30 parts.
Turtle carapace glue nourishing YIN for decreasing fever, resolving hard lump, honey bowl spares emergency can also make the agent for receiving cream.
As a preferred embodiment of the present invention, according to parts by weight include following raw material: 6 parts of rhizoma atractylodis, 10 parts of Poria cocos,
10 parts of endothelium corneum gigeriae galli, 3 parts of Radix picrorrhizae, 8 parts of dark plum, 4 parts of betel nut of stewing, 10 parts of charred FRUCTUS CRATAEGI, 6 parts of Fructus Aurantii, 10 parts of Massa Medicata Fermentata preparata, coloured malt
10 parts, 6 parts of radix glycyrrhizae preparata.
In one preferred embodiment, above-mentioned pharmaceutical composition, further includes: 10 parts and 20 parts of honey of turtle shell rubber powder.
In further embodiment of this invention, a kind of drug being prepared according to above-mentioned Chinese medicine composition is provided.
As a preferred embodiment of the present invention, the dosage form of the drug is decoction, pill, powder, capsule, leaching
Any one in agent, paste or spray.
In further embodiment of this invention, a kind of preparation method of above-mentioned drug is provided, is included the following steps:
Step 1: endothelium corneum gigeriae galli bakes, pulverized powder sieves with 100 mesh sieve hole, obtains endothelium corneum gigeriae galli powder；
Step 2: remaining medicine impregnates 12 hours, high pressure boiling machine is decocted the medicine for three times, and is merged medical fluid, is staticly settled, then with 4 layers of nothing
It bacterium filtered through gauze 3 times, is then concentrated by evaporation, is allowed to gradually into thick shape with 90 DEG C；
Step 3: admixing endothelium corneum gigeriae galli powder.
And in a possible embodiment, further includes: step 4: turtle shell rubber powder, honey, 70 DEG C of receipts cream are added.
The embodiment of the invention provides a kind of Chinese medicine compositions to treat caused by children (within 0-7 years old) eating and drinking without temperance in preparation
Indigestion and loss of appetite deficiency of food, abdominal fullness and distention, feverishness in palms and soles, the uncomfortable, anorexia of stool, dislike purposes in the drug of food illness
Experimental data:
1.1 120, case sources, wherein male 62, women 58, the age 1~7 years old, male's average age 45.94
Month, women average age 48.76 months.The course of disease 7 days to 14 days.
1.2 diagnostic criteria
1.2.1 tcm diagnosis standard
Referring to State Administration of Traditional Chinese Medicine of the People's Republic of China (PRC) " Chinese medical disease Standardization of diagnosis and curative effect TCM Pediatrics disease
It is stagnant to demonstrate,prove Standardization of diagnosis and curative effect " and regular higher education Eleventh Five-Year Plan National planning teaching material " Pediatrics of Chinese Medicine ", " Zhu Futang
Practical paidonosology " in diagnosis basis formulate.
(1) there are wound cream, history of getting ill from overeating.
(2) it with do not feel like eating, eats without digesting, abdominal fullness and distention, diarrhea with loose stool is smelly such as to lose ovum or constipation is characterized.
(3) diseases such as can cry and scream or vomit with dysphoria, night.
(4) the visible indigestion swill of stool laboratory examination or fat drop.
1.2.2 Western medicine diagnostic criteria
Dyspepsia belongs to the disorders of digestion scope of modern medicine, most of to belong to indigestion.
1.3 are included in standard
1.3.1 meet the diagnosis basis of the above TCM Pediatrics dyspepsia and the diagnosis of the doctor trained in Western medicine disorders of digestion.
1.3.2 children age is between 1-7 years old.
1.4 exclusion criteria
1.4.1 the Other diseases person of dyspepsia, or excessive and folder card person can be caused.
1.4.2 merge other severe primary disease patients, such as pancreatitis, cholelithiasis, cholecystalgia, enteritis.
1.4.3 do not meet the standard of being included in, not by regulation medication, can not judge curative effect or data it is not congruent affect the treatment or
Safety judgement person.
2 treatment methods
According to the above-mentioned cream that helps digestion to make without complex, 9g/ packet is taken orally.Within one full year of life children one time 1/3 packet, two to
It wraps within three years old primary half, four to seven years old one time 1 packet, 2 times a day, 7 days are 1 course for the treatment of.During treatment, in addition to above-mentioned treatment,
Without using any other digestant.
3 observation index
It formulates " dyspepsia clinical treatment observation table ", observes the variation of pretherapy and post-treatment cardinal symptom and sign, after 1 course for the treatment of,
Evaluate curative effect.
Symptom and sign standards of grading are formulated as follows:
3.1 curative effect determinate standard
With reference to referring to State Administration of Traditional Chinese Medicine of the People's Republic of China (PRC) " Chinese medical disease Standardization of diagnosis and curative effect Chinese medicine youngster
Section's disease Standardization of diagnosis and curative effect is stagnant " efficacy evaluation: " cure: symptom disappears, and stool is normal.Improve: symptom is changed
It is kind, it defecates normal.Be not cured: symptom is unchanged."
Meanwhile being evaluated according to dyspepsia symptom and sign integral,
(1) clinical recovery: tcm clinical practice symptom, sign disappear or mostly disappear, syndrome integral reduce >=90%.
(2) effective: tcm clinical practice symptom, sign are obviously improved, and syndrome integral reduces >=70%.
(3) effectively: tcm clinical practice symptom, sign take a favorable turn, and syndrome integral reduces >=30%.
(4) invalid: tcm clinical practice symptom, sign are not improved, even aggravating, syndrome integral is reduced less than 30%.
Calculation formula (Nimodipine method) are as follows: [(pre-treatment score-post treatment integral) ÷ pre-treatment score] × 100%.
3.2 health giving quality observation indexs
Cardinal symptom sign is integrated before and after treatment and is evaluated.
The observation of 3.3 adverse events
The adverse events occurred medication early period are observed.
4 results
4.1 efficacy analysis
Clinical efficacy (%) after table 1 is treated
According to curative effect determinate standard, 120 patients fully recover 9, effective 28, effective 72, invalid 11, total effective
Rate 90.8%.
4.2 symptom and signs integral
The integral variation of the pretherapy and post-treatment symptom and sign of table 2
As seen from the above table, which can significantly reduction of patient items Clinical symptom and sign, pretherapy and post-treatment items accumulate
Divide to compare and has significant difference (P < 0.05).
Finally, it should be noted that embodiment described above, only a specific embodiment of the invention, to illustrate the present invention
Technical solution, rather than its limitations, scope of protection of the present invention is not limited thereto, although with reference to the foregoing embodiments to this hair
It is bright to be described in detail, those skilled in the art should understand that: anyone skilled in the art
In the technical scope disclosed by the present invention, it can still modify to technical solution documented by previous embodiment or can be light
It is readily conceivable that variation or equivalent replacement of some of the technical features；And these modifications, variation or replacement, do not make
The essence of corresponding technical solution is detached from the spirit and scope of technical solution of the embodiment of the present invention.Should all it cover in protection of the invention
Within the scope of.Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.
Claims (7)
1. a kind of pharmaceutical composition, which is characterized in that the bulk pharmaceutical chemicals including following parts by weight: 6~12 parts of rhizoma atractylodis, Poria cocos 10~20
Part, 10~20 parts of endothelium corneum gigeriae galli, 3~6 parts of Radix picrorrhizae, 8~16 parts of dark plum, 4~8 parts of betel nut of stewing, 10~20 parts of charred FRUCTUS CRATAEGI, Fructus Aurantii 6
~12 parts, 10~20 parts of Massa Medicata Fermentata preparata, 10~20 parts of coloured malt, 6~12 parts of radix glycyrrhizae preparata.
2. pharmaceutical composition according to claim 1, which is characterized in that further include: 10-20 parts of turtle shell rubber powder and honey
20-30 parts.
3. pharmaceutical composition according to claim 1 characterized by comprising 6 parts of rhizoma atractylodis, 10 parts of Poria cocos, endothelium corneum gigeriae galli 10
Part, 3 parts of Radix picrorrhizae, 8 parts of dark plum, 4 parts of betel nut is simmered, 10 parts of charred FRUCTUS CRATAEGI, 6 parts of Fructus Aurantii, 10 parts of Massa Medicata Fermentata preparata, 10 parts of coloured malt, is processed sweet
6 parts of grass.
4. pharmaceutical composition according to claim 3, which is characterized in that further include: 10 parts and 20 parts of honey of turtle shell rubber powder.
5. a kind of drug that Chinese medicine composition according to claim 1 to 4 is prepared.
6. drug according to claim 5, which is characterized in that the dosage form of the drug is decoction, pill, powder, capsule
Any one in agent, leaching agent, paste or spray.
7. a kind of preparation method of such as drug described in claim 5 or 6, includes the following steps:
Step 1: endothelium corneum gigeriae galli bakes, pulverized powder sieves with 100 mesh sieve hole, obtains endothelium corneum gigeriae galli powder；
Step 2: remaining medicine impregnates 12 hours, high pressure boiling machine is decocted the medicine for three times, and is merged medical fluid, is staticly settled, then with 4 layers of sterile yarn
Cloth filter 23, is then concentrated by evaporation with 90 DEG C, is allowed to gradually into thick shape；
Step 3: admixing endothelium corneum gigeriae galli powder.
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| CN111000962A (en) * | 2019-12-05 | 2020-04-14 | 佛山市禅城区中心医院有限公司 | Chinese patent medicine for treating functional dyspepsia of spleen deficiency and damp stagnation syndrome and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111000962A (en) * | 2019-12-05 | 2020-04-14 | 佛山市禅城区中心医院有限公司 | Chinese patent medicine for treating functional dyspepsia of spleen deficiency and damp stagnation syndrome and preparation method thereof |
| CN111000962B (en) * | 2019-12-05 | 2021-12-17 | 佛山复星禅诚医院有限公司 | Chinese patent medicine for treating functional dyspepsia of spleen deficiency and damp stagnation syndrome and preparation method thereof |
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