CN109097425A - 一种多肽及用作流感疫苗免疫佐剂的用途 - Google Patents
一种多肽及用作流感疫苗免疫佐剂的用途 Download PDFInfo
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- CN109097425A CN109097425A CN201810985423.1A CN201810985423A CN109097425A CN 109097425 A CN109097425 A CN 109097425A CN 201810985423 A CN201810985423 A CN 201810985423A CN 109097425 A CN109097425 A CN 109097425A
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- enzymolysis
- enzymolysis polypeptide
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- C12P21/00—Preparation of peptides or proteins
- C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Abstract
Description
肺指数 | |
空白对照组 | 0.78±0.23 |
HA组 | 1.42±0.29 |
酶解多肽A组 | 1.85±0.34 |
酶解多肽B组 | 1.81±0.35 |
酶解多肽C组 | 1.96±0.31 |
酶解多肽D组 | 1.93±0.38 |
HA+酶解多肽A组 | 0.93±0.22 |
HA+酶解多肽B组 | 0.86±0.24 |
HA+酶解多肽C组 | 1.39±0.37 |
HA+酶解多肽D组 | 0.91±0.20 |
5d存活率(%) | 10d存活率(%) | 15d存活率(%) | |
空白对照组 | 100 | 100 | 100 |
HA组 | 100 | 0 | 0 |
酶解多肽A组 | 0 | 0 | 0 |
酶解多肽B组 | 10 | 0 | 0 |
酶解多肽C组 | 0 | 0 | 0 |
酶解多肽D组 | 0 | 0 | 0 |
HA+酶解多肽A组 | 100 | 100 | 90 |
HA+酶解多肽B组 | 100 | 100 | 100 |
HA+酶解多肽C组 | 100 | 10 | 0 |
HA+酶解多肽D组 | 100 | 100 | 90 |
Claims (6)
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CN201810985423.1A CN109097425B (zh) | 2018-08-28 | 2018-08-28 | 一种多肽及用作流感疫苗免疫佐剂的用途 |
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CN201810985423.1A CN109097425B (zh) | 2018-08-28 | 2018-08-28 | 一种多肽及用作流感疫苗免疫佐剂的用途 |
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CN109097425A true CN109097425A (zh) | 2018-12-28 |
CN109097425B CN109097425B (zh) | 2022-06-07 |
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Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5700911A (en) * | 1993-05-12 | 1997-12-23 | Genetics Institute, Inc. | Bone morphogenetic protein -11 (BMP-11) compositions |
CN107007831A (zh) * | 2017-06-16 | 2017-08-04 | 南京佰泰克生物技术有限公司 | 乙型肝炎dna疫苗的免疫佐剂 |
CN107028101A (zh) * | 2017-03-31 | 2017-08-11 | 安徽中森生物技术有限公司 | 一种补肾益精的组合物及其制备方法 |
CN107287268A (zh) * | 2017-06-16 | 2017-10-24 | 南京佰泰克生物技术有限公司 | 一种增强hiv‑1核酸疫苗免疫原性的佐剂 |
CN107604029A (zh) * | 2017-09-01 | 2018-01-19 | 兰溪市哥特生物技术有限公司 | 利用深海鱼鱼肉制备活性多肽的方法 |
CN108342441A (zh) * | 2018-02-27 | 2018-07-31 | 国肽生物工程(常德)有限公司 | 一种缓解疲劳和抗氧化的牦牛骨蛋白肽及制备方法 |
-
2018
- 2018-08-28 CN CN201810985423.1A patent/CN109097425B/zh active Active
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5700911A (en) * | 1993-05-12 | 1997-12-23 | Genetics Institute, Inc. | Bone morphogenetic protein -11 (BMP-11) compositions |
CN107028101A (zh) * | 2017-03-31 | 2017-08-11 | 安徽中森生物技术有限公司 | 一种补肾益精的组合物及其制备方法 |
CN107007831A (zh) * | 2017-06-16 | 2017-08-04 | 南京佰泰克生物技术有限公司 | 乙型肝炎dna疫苗的免疫佐剂 |
CN107287268A (zh) * | 2017-06-16 | 2017-10-24 | 南京佰泰克生物技术有限公司 | 一种增强hiv‑1核酸疫苗免疫原性的佐剂 |
CN107604029A (zh) * | 2017-09-01 | 2018-01-19 | 兰溪市哥特生物技术有限公司 | 利用深海鱼鱼肉制备活性多肽的方法 |
CN108342441A (zh) * | 2018-02-27 | 2018-07-31 | 国肽生物工程(常德)有限公司 | 一种缓解疲劳和抗氧化的牦牛骨蛋白肽及制备方法 |
Non-Patent Citations (3)
Title |
---|
刁静静等: "骨蛋白水解物的功能特性及抗氧化性的研究进展", 《肉类研究》 * |
崔春: "《食物蛋白质控制酶解技术》", 30 June 2018, 中国轻工业出版社 * |
谭贝妮等: "牛骨蛋白酶解工艺条件的优化", 《食品科学》 * |
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