CN109091665A - The preparation and preparation method thereof for preventing pig cartilage disease - Google Patents
The preparation and preparation method thereof for preventing pig cartilage disease Download PDFInfo
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Abstract
The invention discloses a kind of preparation and preparation method thereof for preventing pig cartilage disease, ingredient and its parts by weight include: 10 ~ 18 parts of psoralea corylifolia, 6 ~ 12 parts of collagen, 1 ~ 3 part of zinc methionine, 1 ~ 3 part of cupric glycinate, 1 ~ 3 part of ferrous fumarate, 15 ~ 30 parts of egg shell, 30 ~ 40 parts of dregs of beans, 0.2 ~ 0.5 part of Radix Astragali, 0.1 ~ 0.4 part and 1 ~ 3 part of vitamin C of folium isatidis.The utility model has the advantages that the present invention is effectively combined the substances such as Chinese herbal medicine effective ingredients, active peptide and vitamin by the glycolysis of bacterium enzyme, when these ingredients reach the lower end of the small intestines such as ileum and part jejunum, calcium ion is surrounded, forms soluble complex.It can be seen that invention formulation can significantly improve absorption of the body to calcium, the biological effectiveness of calcium is improved, promotes growth, the formation and mineralising of bone increase bone weight and content of ashes, thus effectively prevention pig cartilage disease.
Description
Technical field
The present invention relates to pigs to cultivate field, the preparation and preparation method thereof of specifically a kind of prevention pig cartilage disease.
Background technique
Calcium, phosphorus are mainly stored in the form of inorganic salts in animal body, and shared ratio is higher than 7 in the total ash of body
0%, it is a kind of inorganic salts most in body.Calcium, phosphorus are primarily present in animal skeleton and tooth, general in vivo more than 99%
Calcium and phosphorus more than 80% be all present in the two, only there are minimal amounts in body fluid.For adults, itself can lead to
Cross constantly intake and discharge calcium, phosphorus and both ensure dynamic equilibrium, but cub is often compared due to the calcium needed for growing, phosphorus intake
Discharge rate is more, so that the two can also be made to keep normal equilibrium state.Animal is mainly by small intestinal absorption calcium, phosphorus, therefore feed
Contained in calcium, phosphorus ratio and its absorb it is closely related, will be right as long as insoluble substance can be formed in conjunction with calcium, phosphorus
The absorption of calcium, phosphorus impacts.
Long-time feeding management is unreasonable: for example, when calcium and phosphorus containing reduced levels in the feed of pig feeding, such as flood
Root tuber class, forage grass class and the waste matter class feed in depression etc., although calcium contained in feed and phosphorus absolute quantity be not it is very low,
Since ratio is not suitable for, to cause osteomalacia.
It absorbs excessive calcium: when pig intake calcium amount is excessive, calcium ion and bicarbonate ion content in blood being caused to increase
Add, blood pH value is caused to be increased.Body is that blood pH is made to keep balance, meeting separate out from bone tissue at this time
Part bicarbonate ion, and can be combined with each other with blood calcium, it is then discharged in vitro via enteron aisle, prevents alkalosis；Simultaneously
Bicarbonate ion can replace the calcium in bone in part calcium carbonate, prevent acid poisoning, but lead to the obvious decalcification of bone.Again
In addition more phosphide is precipitated in body, tricalcium phosphate level contained in bone is caused to be substantially reduced, to cause osteomalacia.
It feeds excessive acidic feed: when pig feeding roughage is excessive, a large amount of hippuric acid can be generated, lead to calcium
Loss.In addition, usually containing a certain amount of phytic acid in grain feed, the phytate of slightly solubility can be generated in conjunction with calcium, also can
The absorption of calcium is impacted.For example, containing only micro phytase in corn, 8% or so phytic acid can be only about decomposed,
If pig feeding corn will result in calcium deficiency and cause osteomalacia.
Be deficient in vitamin D: in calcium and phosphorus metabolism, vitamin D is had very important effect.Vitamin D is conducive to
So that terminal ileum is absorbed calcium, may additionally facilitate intestinal absorption phosphate；Have the function of inhibiting phytic acid combination calcium, to promote the suction of calcium
It receives；Meanwhile, it is capable to reduce alkaline kation content contained in terminal ileum, colon and caecum, it can also promote the suction of calcium
It receives.Under normal circumstances, as long as calcium, phosphorus ratio are appropriate in daily ration, typically without additional vitamin D.But if pig
Lack sunshine for a long time or the feed of feeding does not receive enough illumination, it can all be made to cause osteomalacia.
Summary of the invention
Soluble complex can be formed with calcium ion under alkaline condition one of the objects of the present invention is to provide a kind of,
Chitling road is improved to the absorption rate of calcium ion, promotes the formation and mineralising of bone, increases bone weight and content of ashes
The preparation for preventing pig cartilage disease.
The second object of the present invention is to provide one kind by the glycolysis of bacterium enzyme, by Chinese herbal medicine effective ingredients, active peptide and dimension
The preparation method of the preparation for the prevention pig cartilage that the substances such as sick element effectively combine.
To achieve the above object, the technical scheme adopted by the invention is as follows: the preparation of prevention pig cartilage disease, ingredient and its weight
Part includes: 10 ~ 18 parts of psoralea corylifolia, 6 ~ 12 parts of collagen, 1 ~ 3 part of zinc methionine, 1 ~ 3 part of cupric glycinate, ferrous fumarate 1 ~ 3
Part, 15 ~ 30 parts of egg shell, 30 ~ 40 parts of dregs of beans, 0.2 ~ 0.5 part of Radix Astragali, 0.1 ~ 0.4 part and 1 ~ 3 part of vitamin C of folium isatidis.
Collagen is specially Isin glue collagen.
The preparation method for preventing the preparation of pig cartilage disease, comprising the following steps:
1) egg shell, dregs of beans, Radix Astragali and folium isatidis are weighed by formula ratio, pulverized；
2) 10 ~ 15 parts of glucose, 3 ~ 8 parts of beef extract and L-(+ are added in material) 0.1 ~ 0.3 part of-ethyl tartrate, it connects
5 ~ 10 parts of bacillus subtilises of kind, 5 ~ 10 parts of acetobacter xylinums, 5 ~ 10 parts of saccharomyces cerevisiaes and 4 ~ 8 parts of papains, bacterium enzyme glycolysis 2
~ 5d, glycolysis temperature are 30 ~ 35 DEG C, and glycolysis pH is 5.0 ~ 7.0, filter to take filtrate；
3) formula ratio psoralea corylifolia, collagen, zinc methionine, cupric glycinate, ferrous fumarate and vitamin are added in filtrate
C, concentrating sterilizing obtains the preparation of prevention pig cartilage disease after mixing.The absorption site of Ca ion is in small intestine, with active absorption
It is carried out with Passive intake two ways.Active absorption is saturated absorption, relies primarily on calbindin (CaBP) and is used as carrier,
Since CaBP is mainly distributed on the upper small intestines such as duodenum, therefore active absorption occurs mainly in upper small intestine.It is passive to inhale
Being received in whole section of small intestine can occur, and depend primarily on the concentration of free calcium in enteric cavity.But account for returning for small intestine very large area
The lower end of the small intestines such as intestines and part jejunum, pH environment are neutral and weak subtracting property, and Ca ion herein can be in conjunction with phosphate anion
At insoluble salt, reduce free calcium concentration.The present invention is by the glycolysis of bacterium enzyme, by Chinese herbal medicine effective ingredients, active peptide and Wei Sheng
The substances such as element effectively combine, and when these ingredients reach the lower end of the small intestines such as ileum and part jejunum, calcium ion is surrounded, is formed
Soluble complex.The calcium ion of enteral is contacted with very high frequency with effective component of the present invention, is discharged, keep free state and
Not by the effect of phosphate radical.It can be seen that invention formulation can significantly improve absorption of the body to calcium, the biology for improving calcium has
Effect property promotes growth, and the formation and mineralising of bone increase bone weight and content of ashes, thus effectively prevention pig cartilage disease.
Compared with the prior art, the advantages of the present invention are as follows: the present invention by the glycolysis of bacterium enzyme, by Chinese herbal medicine effective ingredients,
The substances such as active peptide and vitamin effectively combine, when these ingredients reach the lower end of the small intestines such as ileum and part jejunum, by calcium
Ion surrounds, and forms soluble complex.The calcium ion of enteral is contacted with very high frequency with effective component of the present invention, is discharged,
Keep free state without the effect by phosphate radical.It can be seen that invention formulation can significantly improve absorption of the body to calcium,
The biological effectiveness of calcium is improved, growth is promoted, the formation and mineralising of bone increase bone weight and content of ashes, to have
Effect prevention pig cartilage disease.
Specific embodiment
The present invention program is described further below by embodiment:
Embodiment 1:
Prevent the preparation of pig cartilage disease, ingredient and its parts by weight include: 17 parts of psoralea corylifolia, 10 parts of collagen, zinc methionine 2
Part, 2 parts of cupric glycinate, 2 parts of ferrous fumarate, 18 parts of egg shell, 34 parts of dregs of beans, 0.3 part of Radix Astragali, 0.2 part of folium isatidis and dimension life
It is C2 parts plain.
Collagen is specially Isin glue collagen.
The preparation method for preventing the preparation of pig cartilage disease, comprising the following steps:
1) egg shell, dregs of beans, Radix Astragali and folium isatidis are weighed by formula ratio, pulverized；
2) 14 parts of glucose, 3 parts of beef extract and L-(+ are added in material) 0.2 part of-ethyl tartrate, it is inoculated with 7 portions of withered grass
Bacillus, 8 parts of acetobacter xylinums, 8 parts of saccharomyces cerevisiaes and 6 parts of papains, bacterium enzyme glycolysis 4d, glycolysis temperature are 32 DEG C, ferment
Solving pH is 6.0, filters to take filtrate；
3) formula ratio psoralea corylifolia, collagen, zinc methionine, cupric glycinate, ferrous fumarate and vitamin are added in filtrate
C, concentrating sterilizing obtains the preparation of prevention pig cartilage disease after mixing.The absorption site of Ca ion is in small intestine, with active absorption
It is carried out with Passive intake two ways.Active absorption is saturated absorption, relies primarily on calbindin (CaBP) and is used as carrier,
Since CaBP is mainly distributed on the upper small intestines such as duodenum, therefore active absorption occurs mainly in upper small intestine.It is passive to inhale
Being received in whole section of small intestine can occur, and depend primarily on the concentration of free calcium in enteric cavity.But account for returning for small intestine very large area
The lower end of the small intestines such as intestines and part jejunum, pH environment are neutral and weak subtracting property, and Ca ion herein can be in conjunction with phosphate anion
At insoluble salt, reduce free calcium concentration.The present invention is by the glycolysis of bacterium enzyme, by Chinese herbal medicine effective ingredients, active peptide and Wei Sheng
The substances such as element effectively combine, and when these ingredients reach the lower end of the small intestines such as ileum and part jejunum, calcium ion is surrounded, is formed
Soluble complex.The calcium ion of enteral is contacted with very high frequency with effective component of the present invention, is discharged, keep free state and
Not by the effect of phosphate radical.It can be seen that invention formulation can significantly improve absorption of the body to calcium, the biology for improving calcium has
Effect property promotes growth, and the formation and mineralising of bone increase bone weight and content of ashes, thus effectively prevention pig cartilage disease.
Embodiment 2:
Prevent the preparation of pig cartilage disease, ingredient and its parts by weight include: 13 parts of psoralea corylifolia, 9 parts of collagen, 2 parts of zinc methionine,
2 parts of cupric glycinate, 3 parts of ferrous fumarate, 24 parts of egg shell, 36 parts of dregs of beans, 0.4 part of Radix Astragali, 0.3 part of folium isatidis and vitamin C 3
Part.
Collagen is specially Isin glue collagen.
The preparation method for preventing the preparation of pig cartilage disease, comprising the following steps:
1) egg shell, dregs of beans, Radix Astragali and folium isatidis are weighed by formula ratio, pulverized；
2) 13 parts of glucose, 4 parts of beef extract and L-(+ are added in material) 0.3 part of-ethyl tartrate, it is inoculated with 8 portions of withered grass
Bacillus, 8 parts of acetobacter xylinums, 9 parts of saccharomyces cerevisiaes and 6 parts of papains, bacterium enzyme glycolysis 4d, glycolysis temperature are 35 DEG C, ferment
Solving pH is 5.5, filters to take filtrate；
3) formula ratio psoralea corylifolia, collagen, zinc methionine, cupric glycinate, ferrous fumarate and vitamin are added in filtrate
C, concentrating sterilizing obtains the preparation of prevention pig cartilage disease after mixing.The absorption site of Ca ion is in small intestine, with active absorption
It is carried out with Passive intake two ways.Active absorption is saturated absorption, relies primarily on calbindin (CaBP) and is used as carrier,
Since CaBP is mainly distributed on the upper small intestines such as duodenum, therefore active absorption occurs mainly in upper small intestine.It is passive to inhale
Being received in whole section of small intestine can occur, and depend primarily on the concentration of free calcium in enteric cavity.But account for returning for small intestine very large area
The lower end of the small intestines such as intestines and part jejunum, pH environment are neutral and weak subtracting property, and Ca ion herein can be in conjunction with phosphate anion
At insoluble salt, reduce free calcium concentration.The present invention is by the glycolysis of bacterium enzyme, by Chinese herbal medicine effective ingredients, active peptide and Wei Sheng
The substances such as element effectively combine, and when these ingredients reach the lower end of the small intestines such as ileum and part jejunum, calcium ion is surrounded, is formed
Soluble complex.The calcium ion of enteral is contacted with very high frequency with effective component of the present invention, is discharged, keep free state and
Not by the effect of phosphate radical.It can be seen that invention formulation can significantly improve absorption of the body to calcium, the biology for improving calcium has
Effect property promotes growth, and the formation and mineralising of bone increase bone weight and content of ashes, thus effectively prevention pig cartilage disease.
Embodiment 3:
Prevent the preparation of pig cartilage disease, ingredient and its parts by weight include: 16 parts of psoralea corylifolia, 11 parts of collagen, zinc methionine 3
Part, 2 parts of cupric glycinate, 1 part of ferrous fumarate, 27 parts of egg shell, 32 parts of dregs of beans, 0.4 part of Radix Astragali, 0.3 part of folium isatidis and dimension life
It is C3 parts plain.
Collagen is specially Isin glue collagen.
The preparation method for preventing the preparation of pig cartilage disease, comprising the following steps:
1) egg shell, dregs of beans, Radix Astragali and folium isatidis are weighed by formula ratio, pulverized；
2) 13 parts of glucose, 7 parts of beef extract and L-(+ are added in material) 0.3 part of-ethyl tartrate, it is inoculated with 9 portions of withered grass
Bacillus, 7 parts of acetobacter xylinums, 8 parts of saccharomyces cerevisiaes and 6 parts of papains, bacterium enzyme glycolysis 3d, glycolysis temperature are 34 DEG C, ferment
Solving pH is 6.0, filters to take filtrate；
3) formula ratio psoralea corylifolia, collagen, zinc methionine, cupric glycinate, ferrous fumarate and vitamin are added in filtrate
C, concentrating sterilizing obtains the preparation of prevention pig cartilage disease after mixing.The absorption site of Ca ion is in small intestine, with active absorption
It is carried out with Passive intake two ways.Active absorption is saturated absorption, relies primarily on calbindin (CaBP) and is used as carrier,
Since CaBP is mainly distributed on the upper small intestines such as duodenum, therefore active absorption occurs mainly in upper small intestine.It is passive to inhale
Being received in whole section of small intestine can occur, and depend primarily on the concentration of free calcium in enteric cavity.But account for returning for small intestine very large area
The lower end of the small intestines such as intestines and part jejunum, pH environment are neutral and weak subtracting property, and Ca ion herein can be in conjunction with phosphate anion
At insoluble salt, reduce free calcium concentration.The present invention is by the glycolysis of bacterium enzyme, by Chinese herbal medicine effective ingredients, active peptide and Wei Sheng
The substances such as element effectively combine, and when these ingredients reach the lower end of the small intestines such as ileum and part jejunum, calcium ion is surrounded, is formed
Soluble complex.The calcium ion of enteral is contacted with very high frequency with effective component of the present invention, is discharged, keep free state and
Not by the effect of phosphate radical.It can be seen that invention formulation can significantly improve absorption of the body to calcium, the biology for improving calcium has
Effect property promotes growth, and the formation and mineralising of bone increase bone weight and content of ashes, thus effectively prevention pig cartilage disease.
Routine operation in operating procedure of the invention is well known to those skilled in the art, herein without repeating.
Technical solution of the present invention is described in detail in embodiment described above, it should be understood that the above is only
For specific embodiments of the present invention, it is not intended to restrict the invention, all any modifications made in spirit of the invention,
Supplement or similar fashion substitution etc., should all be included in the protection scope of the present invention.
Claims (4)
1. the preparation for preventing pig cartilage disease, it is characterised in that ingredient and its parts by weight include: 10 ~ 18 parts of psoralea corylifolia, collagen 6
~ 12 parts, 1 ~ 3 part of zinc methionine, 1 ~ 3 part of cupric glycinate, 1 ~ 3 part of ferrous fumarate, 15 ~ 30 parts of egg shell, 30 ~ 40 parts of dregs of beans,
0.2 ~ 0.5 part of Radix Astragali, 0.1 ~ 0.4 part and 1 ~ 3 part of vitamin C of folium isatidis.
2. the preparation of prevention pig cartilage disease according to claim 1, it is characterised in that: the collagen is specially fish
Collagen.
3. the preparation method for preventing the preparation of pig cartilage disease, it is characterised in that the following steps are included:
1) egg shell, dregs of beans, Radix Astragali and folium isatidis are weighed by formula ratio, pulverized；
2) 10 ~ 15 parts of glucose, 3 ~ 8 parts of beef extract and L-(+ are added in material) 0.1 ~ 0.3 part of-ethyl tartrate, it connects
5 ~ 10 parts of bacillus subtilises of kind, 5 ~ 10 parts of acetobacter xylinums, 5 ~ 10 parts of saccharomyces cerevisiaes and 4 ~ 8 parts of papains, bacterium enzyme glycolysis 2
~ 5d, filters to take filtrate；
3) formula ratio psoralea corylifolia, collagen, zinc methionine, cupric glycinate, ferrous fumarate and vitamin are added in filtrate
C, concentrating sterilizing obtains the preparation of prevention pig cartilage disease after mixing.
4. the preparation of prevention pig cartilage disease according to claim 3, it is characterised in that: the glycolysis temperature is 30 ~ 35
DEG C, glycolysis pH is 5.0 ~ 7.0.
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Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101578051A (en) * | 2006-12-06 | 2009-11-11 | 美国硼砂公司 | Animal feed compositions |
| CN102429114A (en) * | 2011-11-02 | 2012-05-02 | 刘鹏 | Health-care product for teating swine chondropathy |
| CN102512574A (en) * | 2011-12-20 | 2012-06-27 | 青岛农业大学 | Traditional Chinese medicine composition for treating animal rickets, its preparation method and its application |
| CN103734507A (en) * | 2013-12-12 | 2014-04-23 | 济南新起点医药科技有限公司 | Fermentation preparation method of laying hen feed |
| CN103766636A (en) * | 2012-10-25 | 2014-05-07 | 蔡田湉 | Fodder for treating pig osteomalacia |
| CN103892065A (en) * | 2012-12-27 | 2014-07-02 | 邢果花 | Feed composition for preventing bovine osteomalacia |
| CN106307551A (en) * | 2016-08-22 | 2017-01-11 | 邵玉华 | Method for preparing organic calcium with eggshells |
| CN108077620A (en) * | 2017-12-21 | 2018-05-29 | 梁国生 | It is a kind of to be used to prevent pannage of pig soft bone disease and preparation method thereof |
-
2018
- 2018-06-13 CN CN201810605552.3A patent/CN109091665A/en not_active Withdrawn
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101578051A (en) * | 2006-12-06 | 2009-11-11 | 美国硼砂公司 | Animal feed compositions |
| CN102429114A (en) * | 2011-11-02 | 2012-05-02 | 刘鹏 | Health-care product for teating swine chondropathy |
| CN102512574A (en) * | 2011-12-20 | 2012-06-27 | 青岛农业大学 | Traditional Chinese medicine composition for treating animal rickets, its preparation method and its application |
| CN103766636A (en) * | 2012-10-25 | 2014-05-07 | 蔡田湉 | Fodder for treating pig osteomalacia |
| CN103892065A (en) * | 2012-12-27 | 2014-07-02 | 邢果花 | Feed composition for preventing bovine osteomalacia |
| CN103734507A (en) * | 2013-12-12 | 2014-04-23 | 济南新起点医药科技有限公司 | Fermentation preparation method of laying hen feed |
| CN106307551A (en) * | 2016-08-22 | 2017-01-11 | 邵玉华 | Method for preparing organic calcium with eggshells |
| CN108077620A (en) * | 2017-12-21 | 2018-05-29 | 梁国生 | It is a kind of to be used to prevent pannage of pig soft bone disease and preparation method thereof |
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