CN109078123A - 一种治疗骨癌的中药组合物及其制备方法 - Google Patents
一种治疗骨癌的中药组合物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗骨癌的中药组合物包括:黄芪,杜仲炭,菟丝子,天麻,太子参,玉竹参,赤芍,白芍,白芨,石斛,麦冬,沙参,桃仁,知母,白花蛇舌草,桑寄生,怀牛膝,延胡索,宣木瓜,蛤蚧,蚯蚓,白僵蚕,瓜蒌,川贝母,黄精,牡丹皮,鹿角霜,鸡血藤,忍冬藤,酸枣仁,柏子仁,甘草,龟板和鳖甲,制备方法为:将煎煮后的龟板、鳖甲加入至经过浸泡后的余下原料中,继续浸泡后煎煮,过滤得到第一次的药剂和药渣,向药渣中加入水,再次煎煮,过滤得到第二次的药剂,将第一次的药剂和第二次的药剂混合后即得。本发明治疗骨癌的中药组合物对治疗躯干骨中的脊椎、胸椎、肋骨、腰椎、颈椎、骶骨及额骨、肩胛骨等均有一定的疗效,安全可靠。
Description
技术领域
本发明涉及一种中药组合物及其制备方法,具体涉及一种治疗骨癌的中药组合物及其制备方法,属于医药领域。
背景技术
骨肿瘤是发生于骨骼或其附属组织(血管、神经、骨髓等)的肿瘤,是常见病。同身体其它组织一样,其确切病因不明;骨肿瘤有良性,恶性之分,良性骨肿瘤易根治,预后良好,恶性骨肿瘤发展迅速,预后不佳,死亡率高,至今尚无满意的治疗方法。恶性骨肿瘤可以是原发的,也可以是继发的,从体内其它组织或器官的恶性肿瘤经血液循环,淋巴系统转移至骨骼或直接侵犯骨骼。还有一类病损称瘤样病变,肿瘤样病变的组织不具有肿瘤细胞形态的特点,但其生态和行为都具有肿瘤的破坏性,一般较局限,易根治。
骨癌在中医上属于“骨痨”、“骨瘤”等范畴。骨癌症状主要有疼痛、贫血、全身乏力有麻木感、营养不良和病理性改变骨折等。局部疼痛和压痛为最常见症状,可与肿块同时出现或先出现,呈间歇性钝痛,后来逐渐变为持续性剧痛。浅表部位可触及骨膨胀变形及软组织肿块,皮肤呈暗红色,皮温增高,短期内形成较大肿块,功能障碍,骨骼畸形等。骨癌的中医治疗于手术、放疗、化疗相结合,可提高疗效。
一、骨癌的中医治疗针对不同的个体,不同患者的身体情况,制定因人而宜的治疗方案。可以随着病情的进展,方剂上药材不断增减,不断变化。中草药会发挥的作用非常大。其实这是中医最大的特点,气候的调整、症状的改善,要因人制宜,因时制宜。
二、中医对于全身调整更有优势,早期治疗可以和其它治疗方式配合。控制症状、改善症状、改善长期的趋势方面中医方面优势是很明显的。另外化疗期间,配合中药,可以明显的增加骨密度,控制骨的病变改善疼痛。
发明内容
有鉴于此,本发明提供了一种治疗骨癌的中药组合物及其制备方法,以骨癌,多数发生于躯干骨中。以脊椎、胸椎、腰椎和额骨恶性病变为病机,进行药物组方,确定药性对疾病机理、机制中的转变、缩少和消亡的过程,以及多方位的气化演变,最终将癌细胞迅速逆转为人体正常生理细胞。
为了实现上述目的,本发明采用如下技术方案:
一种治疗骨癌的中药组合物,以重量份计,包括以下组分:黄芪20-30份,杜仲炭15-25份,菟丝子20-30份,天麻20-30份,太子参15-25份,玉竹参15-25份,赤芍15-25份,白芍15-25份,白芨20-30份,石斛15-25份,麦冬15-25份,沙参15-25份,桃仁15-20份,知母15-20份,白花蛇舌草20-30份,桑寄生15-25份,怀牛膝15-25份,延胡索15-25份,宣木瓜15-25份,蛤蚧一对,蚯蚓15-25份,白僵蚕15-25份,瓜蒌15-25份,川贝母15-25份,黄精15-25份,牡丹皮15-25份,鹿角霜20-30份,鸡血藤25-35份,忍冬藤25-35份,酸枣仁20-30份,柏子仁20-30份及甘草10-20份;还包括龟板25-35份,鳖甲25-35份。
本发明治疗治疗骨癌的中药组合物以益气养阴、滋补肾髓、软坚化瘀为理论基础进行组药,各种原料药相互协调在一起能够最大程度的发挥药效,有效的治疗发生在骨髓系统各种组织如骨软骨、纤维组织、脂肪组织、造血组织、神经组织和未分化的网状内皮结构等引起的肿瘤均属原发性骨肿瘤,以及通过直接浸润、血运和淋巴系统转移而在骨组织内形成的转移肿瘤为继发生骨肿瘤所引起的各种常见的治疗症状,对治疗躯干骨中的脊椎、胸椎、肋骨、腰椎、颈椎、骶骨,以及额骨、肩胛骨等均有一定的疗效,安全可靠。
黄芪,性温,味甘,补气固表,托毒排脓,利尿,生肌,用于气虚乏力、久泻脱肛、自汗、水肿、子官脱垂、慢性肾炎蛋白尿、糖尿病、疮口久不愈合。
杜仲炭,性温,味甘,微辛,入肝、肾经,补肝肾,强筋骨,安胎,治腰脊酸疼,肢体痿弱,遗精,滑精,五更泄泻,虚劳,小便余沥,阴下湿痒,胎动不安,胎漏欲堕,胎水肿满,滑胎,高血压。
菟丝子,味辛、甘,性平,归肝、肾、脾经,补益肝肾,固精缩尿,安胎,明目,止泻;外用消风祛斑。
天麻,甘,平,入肝经,息风,定惊,治眩晕眼黑,头风头痛,肢体麻木,半身不遂,语言蹇涩,小儿惊痫动风。
太子参,味甘、微苦,性平,归脾、肺经,益气健脾,生津润肺。用于脾虚体倦,食欲不振,病后虚弱,气阴不足,自汗口渴,肺燥干咳。
玉竹参,养阴润燥,生津止渴,用于肺胃阴伤,燥热咳嗽,咽干口渴,内热消渴。
赤白芍,气味苦平,无毒,主治邪气腹痛,除血痹,破坚积,寒热,病疲,止痛,利小便,益气。
白芨,味苦、甘、涩,微寒,归肺、肝、胃经,.收敛止血,消肿生肌,用于咳血吐血,外伤出血,疮疡肿毒,皮肤皲裂,肺结核咳血,溃疡病出血。
石斛,味甘,性微寒,归胃、肾经,益胃生津,滋阴清热,用于热病津伤,口干烦渴,胃阴不足,食少干呕,病后虚热不退,阴虚火旺,骨蒸劳热,目暗不明,筋骨痿软。
麦冬,味甘,微苦,微寒,归心、肺、胃经,养阴生津,润肺止咳,用于肺胃阴虚之津少口渴、干咳咯血,心阴不足之心悸易惊及热病后期热伤津液等。
沙参,味甘、微苦,性微寒,归肺、胃经,养阴清热,润肺化痰,益胃生津,用于阴虚久咳,痨嗽痰血,燥咳痰少,虚热喉痹,津伤口渴。
桃仁,味苦、甘,平,归心、肝、大肠经,活血祛瘀,润肠通便,止咳平喘,用于经闭痛经,瘕瘕痞块,肺痈肠痈,跌扑损伤,肠燥便秘,咳嗽气喘。
知母,味苦,寒,归肺、胃、肾经,清热泻火,滋阴润燥,主治热病烦渴,肺热燥咳,骨蒸潮热,内热消渴,肠燥便秘。
白花蛇舌草,味微苦,性寒,归胃、大肠、小肠经,清热解毒,利湿通淋,用于肺热喘咳,咽喉肿痛,肠痈,疖肿疮疡,毒蛇咬伤,热淋涩痛,水肿,痢疾,肠炎,湿热黄疸,癌肿。
桑寄生,味苦、甘,性平,归肝、肾经,有祛风湿,补肝肾,强筋骨,安胎元的作用,用于风湿痹痛,腰膝酸软,筋骨无力,崩漏经多,妊娠漏血,胎动不安,头晕目眩。
怀牛膝,气味苦酸,平,主治寒湿痿痹、四肢拘挛,膝痛不可屈伸,逐血气,伤热火烂,久服轻身耐老,长于补益肝肾,强腰膝以及活血、引血下行。
延胡索,性辛、苦,温,归肝、脾经,活血,行气,止痛,用于胸胁、脘腹疼痛,胸痹心痛,经闭痛经,产后瘀阻,跌扑肿痛。
宣木瓜,性温,味酸,归肝、脾经,平肝舒筋,和胃化湿。主治:用于湿痹拘挛,腰膝关节酸重疼痛,吐泻转筋,脚气水肿。
蛤蚧,味咸,性平,归肺、肾经,补肺益肾,纳气定喘,助阳益精,用于肺肾不足,虚喘气促,劳嗽咳血,阳痿,遗精。
蚯蚓,味咸,性寒,入肝、脾、肺经,清热,平肝,止喘,通络,治高热狂躁,惊风抽搐,风热头痛,目赤,中风半身不遂,喘息,喉痹,关节疼痛,齿衄,小便不通,瘰疬。痄腮,疮疡。
白僵蚕,辛咸,平,入肝、肺,胃经,祛风解痉,化痰散结,治中风失音,惊痫,头风,喉风。喉痹,瘰疬结核。风疮瘾疹,丹毒,乳腺炎。
瓜蒌,性寒,味甘,微苦,清热涤痰,宽胸散结,润肠,用于肺热咳嗽,痰浊黄稠,胸痹心痛,乳痈、肺痈、肠痈肿痛。
川贝母,味苦、甘,性微寒,归肺、心经,清热润肺,化痰止咳,散结消痈,用于肺热燥咳,干咳少痰,阴虚劳嗽,痰中带血,瘰疬,乳痈,肺痈。
黄精,味甘,性平,归脾、肺、肾经,补气养阴,健脾,润肺,益肾,用于脾胃气虚,体倦乏力,胃阴不足,口干食少,肺虚燥咳,劳嗽咳血,精血不足,腰膝酸软,须发早白,内热消渴。
牡丹皮,苦、辛,微寒,归心、肝、肾经,清热凉血,活血化瘀,热入营血,温毒发斑,吐血衄血,夜热早凉,无汗骨蒸,经闭痛经,跌扑伤痛,痈肿疮毒。
鹿角霜,味咸、涩,性温,归肝、肾经,温肾助阳,收敛止血,用于脾肾阳虚,白带过多,遗尿尿频,崩漏下血,疮疡不敛等病症的治疗。
鸡血藤,苦、甘,温,归肝、肾经,活血补血,调经止痛,舒筋活络,用于月经不调,痛经,经闭,风湿痹痛,麻木瘫痪,血虚萎黄。
忍冬藤,甘,寒,归肺、胃经,清热解毒,疏风通络,温病发热,热毒血痢,痈肿疮疡,风湿热痹,关节红肿热痛。
酸枣仁,味甘,性平,入心、脾、肝、胆经,养肝,宁心,安神,敛汗,治虚烦不眠,惊悸怔忡,烦渴,虚汗。
柏子仁,味甘,性平,归心、肾、大肠经,养心安神,润肠通便,止汗,用于阴血不足,虚烦失眠,心悸怔忡,肠燥便秘,阴虚盗汗。
龟板,味咸甘,性平,滋阴,潜阳,补肾,健骨,治肾阴不足,骨蒸劳热,吐血,衄血,久咳,遗精,崩漏,带下,腰痛,骨痿,阴虚风动,久痢,久疟,痔疮,小儿囟门不合。
鳖甲,味咸,性微寒,归肝、肾经,滋阴潜阳,退热除蒸,软坚散结,用于阴虚发热,骨蒸劳热,阴虚阳亢,头晕目眩,虚风内动,经闭,癥瘕,久疟,疟母。
甘草,味甘,性平,归心、肺、脾、胃经,补脾益气,清热解毒,祛痰止咳,缓急止痛,调和诸药,用于脾胃虚弱,倦怠乏力,心悸气短,咳嗽痰多,脘腹、四肢挛急疼痛,痈肿疮毒,缓解药物毒性、烈性。
对症的药物组方进行气化介入人体内气化中枢(脾胃),进行气体交换(机制)的升降出入,进入病灶,迅速遏制癌细胞的扩散和转移,直接摧毁突变的癌细胞去修复缺失变异的细胞和细胞质,经多方位的气化演变,稳妥有序地将癌细胞迅速逆转为正常生理细胞。
所谓“气化”,就是说自然界中的各种生命现象,是在自然界正常气候变化的基础上产生的,有气然后有化,没有气就没有化。“天元纪大论篇”中所述:“在天为气,在地为形,形气相感而化生万物矣”、因此《黄帝内经》对于人体生理和病理生理的认识也完全是从“气化”的角度来认识,从“气化”的角度出发来研究人体的生理现象、病理现象、疾病的诊断、治疗和预防原则,从而通过气化的演变迅速达到根治肿瘤的目的。
进一步,酸枣仁为炒制酸枣仁,柏子仁为炒制柏子仁。
采用上述进一步的有益效果在于,酸枣仁和柏子仁均为养心安神类中药,中药讲究的是逢子必炒,一般情况下生药入口会比较容易伤胃,经过炒制之后药性会更加温和。
本发明还提供了上述治疗骨癌的中药组合物的制备方法,包括以下步骤:
(1)按上述的重量份数称取各原料;
(2)将98-120℃煎煮20-30min后的龟板、鳖甲加入至经过0-5℃浸泡60-90min后的余下原料中,继续浸泡60-90min,备用;
(3)将浸泡好的原料煎煮,过滤得到第一次的药剂和药渣,备用;
(4)向药渣中加入水,再次煎煮,过滤得到第二次的药剂;
(5)将第一次的药剂和第二次的药剂混合后即得治疗骨癌的中药组合物。
本发明治疗骨癌的中药组合物的制备方法操作简单,条件温和,能使药效达到最大。
进一步,步骤(3)和/或步骤(4)中所述的煎煮为100-120℃煎煮至水沸腾后降温至85-100℃,煎煮45-55min。
用法用量:经上述步骤制备得到的治疗骨癌的中药组合物分两天服用,每日三次,早饭后一小时至一小时半服药,剂量为120-150毫升;中午饭后一小时半服药,剂量为120毫升;晚饭后一小时半服药,剂量为120-150毫升。忌辛辣、烟酒、避风寒暑热、室内通风光线明亮,个人心情舒畅,营造良好的生活环境。
具体实施方式
下面将对本发明实施例中的技术方案进行清楚、完整地描述,显然,所描述的实施例仅仅是本发明一部分实施例,而不是全部的实施例。基于本发明中的实施例,本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例,都属于本发明保护的范围。
实施例1
治疗骨癌的中药组合物,包括:黄芪20g,杜仲炭15g,菟丝子20g,天麻20g,太子参15g,玉竹参15g,赤芍15g,白芍15g,白芨20g,石斛15g,麦冬15g,沙参15g,桃仁15g,知母15g,白花蛇舌草20g,桑寄生15g,怀牛膝15g,延胡索15g,宣木瓜15g,蛤蚧一对,蚯蚓15g,白僵蚕15g,瓜蒌15g,川贝母15g,黄精15g,牡丹皮15g,鹿角霜20g,鸡血藤25g,忍冬藤25g,酸枣仁20g,柏子仁20g,甘草10g,龟板25g,鳖甲25g
制备方法如下:
(1)按上述质量称取各原料;
(2)将100℃煎煮20min后的龟板、鳖甲加入至经过0℃浸泡90min后的黄芪,杜仲炭,菟丝子,天麻,太子参,玉竹参,赤芍,白芍,白芨,石斛,麦冬,沙参,桃仁,知母,白花蛇舌草,桑寄生,怀牛膝,延胡索,宣木瓜,蛤蚧,蚯蚓,白僵蚕,瓜蒌,川贝母,黄精,牡丹皮,鹿角霜,鸡血藤,忍冬藤,酸枣仁,柏子仁,甘草的混合物中,继续浸泡60min,备用;
(3)将浸泡好的原料100℃煎煮至水沸腾后降温至85℃,煎煮45min,过滤得到第一次的药剂和药渣,备用;
(4)向药渣中加入水,100℃煎煮至水沸腾后降温至85℃,煎煮45min,过滤得到第二次的药剂;
(5)将第一次的药剂和第二次的药剂混合后即得治疗骨癌的中药组合物,分两天服用,每日三次,早饭后一小时至一小时半服药,剂量为120毫升;中午饭后一小时半服药,剂量为120毫升;晚饭后一小时半服药,剂量为120毫升。
实施例2
治疗骨癌的中药组合物,包括:黄芪30g,杜仲炭25g,菟丝子30g,天麻30g,太子参25g,玉竹参25g,赤芍25g,白芍25g,白芨30g,石斛25g,麦冬25g,沙参25g,桃仁20g,知母20g,白花蛇舌草30g,桑寄生25g,怀牛膝25g,延胡索25g,宣木瓜25g,蛤蚧一对,蚯蚓25g,白僵蚕25g,瓜蒌25g,川贝母25g,黄精25g,牡丹皮25g,鹿角霜20g,鸡血藤35g,忍冬藤25g,酸枣仁30g,柏子仁20g,甘草20g,龟板35g,鳖甲35g
制备方法如下:
(1)按上述质量称取各原料;
(2)将100℃煎煮20min后的龟板、鳖甲加入至经过0℃浸泡90min后的黄芪,杜仲炭,菟丝子,天麻,太子参,玉竹参,赤芍,白芍,白芨,石斛,麦冬,沙参,桃仁,知母,白花蛇舌草,桑寄生,怀牛膝,延胡索,宣木瓜,蛤蚧,蚯蚓,白僵蚕,瓜蒌,川贝母,黄精,牡丹皮,鹿角霜,鸡血藤,忍冬藤,酸枣仁,柏子仁,甘草的混合物中,继续浸泡60min,备用;
(3)将浸泡好的原料120℃煎煮至水沸腾后降温至100℃,煎煮55min,过滤得到第一次的药剂和药渣,备用;
(4)向药渣中加入水,120℃煎煮至水沸腾后降温至100℃,煎煮55min,过滤得到第二次的药剂;
(5)将第一次的药剂和第二次的药剂混合后即得治疗骨癌的中药组合物,分两天服用,每日三次,早饭后一小时至一小时半服药,剂量为150毫升;中午饭后一小时半服药,剂量为120毫升;晚饭后一小时半服药,剂量为150毫升。
实施例3
治疗骨癌的中药组合物,包括:黄芪25g,杜仲炭20g,菟丝子25g,天麻25g,太子参20g,玉竹参20g,赤芍20g,白芍20g,白芨25g,石斛20g,麦冬20g,沙参20g,桃仁18g,知母18g,白花蛇舌草25g,桑寄生20g,怀牛膝20g,延胡索20g,宣木瓜20g,蛤蚧一对,蚯蚓20g,白僵蚕20g,瓜蒌20g,川贝母20g,黄精20g,牡丹皮20g,鹿角霜25g,鸡血藤30g,忍冬藤30g,酸枣仁25g,柏子仁25g,甘草15g,龟板30g,鳖甲30g
制备方法如下:
(1)按上述质量称取各原料;
(2)将100℃煎煮20min后的龟板、鳖甲加入至经过0℃浸泡90min后的黄芪,杜仲炭,菟丝子,天麻,太子参,玉竹参,赤芍,白芍,白芨,石斛,麦冬,沙参,桃仁,知母,白花蛇舌草,桑寄生,怀牛膝,延胡索,宣木瓜,蛤蚧,蚯蚓,白僵蚕,瓜蒌,川贝母,黄精,牡丹皮,鹿角霜,鸡血藤,忍冬藤,酸枣仁,柏子仁,甘草的混合物中,继续浸泡60min,备用;
(3)将浸泡好的原料100℃煎煮至水沸腾后降温至85℃,煎煮50min,过滤得到第一次的药剂和药渣,备用;
(4)向药渣中加入水,100℃煎煮至水沸腾后降温至85℃,煎煮50min,过滤得到第二次的药剂;
(5)将第一次的药剂和第二次的药剂混合后即得治疗骨癌的中药组合物,分两天服用,每日三次,早饭后一小时至一小时半服药,剂量为130毫升;中午饭后一小时半服药,剂量为120毫升;晚饭后一小时半服药,剂量为150毫升。
实施例4
治疗骨癌的中药组合物,包括:黄芪20g,杜仲炭25g,菟丝子20g,天麻30g,太子参15g,玉竹参15g,赤芍25g,白芍15g,白芨30g,石斛15g,麦冬25g,沙参15g,桃仁15g,知母20g,白花蛇舌草20g,桑寄生25g,怀牛膝15g,延胡索25g,宣木瓜1g,蛤蚧一对,蚯蚓15g,白僵蚕25g,瓜蒌25g,川贝母25g,黄精25g,牡丹皮15g,鹿角霜20g,鸡血藤35g,忍冬藤35g,酸枣仁20g,柏子仁20g,甘草20g,龟板35g,鳖甲25g
制备方法如下:
(1)按上述质量称取各原料;
(2)将100℃煎煮20min后的龟板、鳖甲加入至经过0℃浸泡90min后的黄芪,杜仲炭,菟丝子,天麻,太子参,玉竹参,赤芍,白芍,白芨,石斛,麦冬,沙参,桃仁,知母,白花蛇舌草,桑寄生,怀牛膝,延胡索,宣木瓜,蛤蚧,蚯蚓,白僵蚕,瓜蒌,川贝母,黄精,牡丹皮,鹿角霜,鸡血藤,忍冬藤,酸枣仁,柏子仁,甘草的混合物中,继续浸泡60min,备用;
(3)将浸泡好的原料120℃煎煮至水沸腾后降温至85℃,煎煮55min,过滤得到第一次的药剂和药渣,备用;
(4)向药渣中加入水,100℃煎煮至水沸腾后降温至85℃,煎煮45min,过滤得到第二次的药剂;
(5)将第一次的药剂和第二次的药剂混合后即得治疗骨癌的中药组合物,分两天服用,每日三次,早饭后一小时至一小时半服药,剂量为150毫升;中午饭后一小时半服药,剂量为120毫升;晚饭后一小时半服药,剂量为150毫升。
实施例5
治疗骨癌的中药组合物,包括:黄芪30g,杜仲炭25g,菟丝子20g,天麻30g,太子参15g,玉竹参25g,赤芍15g,白芍25g,白芨20g,石斛25g,麦冬15g,沙参25g,桃仁15g,知母20g,白花蛇舌草20g,桑寄生25g,怀牛膝15g,延胡索25g,宣木瓜15g,蛤蚧一对,蚯蚓25g,白僵蚕15g,瓜蒌25g,川贝母15g,黄精25g,牡丹皮25g,鹿角霜20g,鸡血藤35g,忍冬藤35g,酸枣仁20g,柏子仁30g,甘草20g,龟板25g,鳖甲25g
制备方法如下:
(1)按上述质量称取各原料;
(2)将100℃煎煮20min后的龟板、鳖甲加入至经过0℃浸泡90min后的黄芪,杜仲炭,菟丝子,天麻,太子参,玉竹参,赤芍,白芍,白芨,石斛,麦冬,沙参,桃仁,知母,白花蛇舌草,桑寄生,怀牛膝,延胡索,宣木瓜,蛤蚧,蚯蚓,白僵蚕,瓜蒌,川贝母,黄精,牡丹皮,鹿角霜,鸡血藤,忍冬藤,酸枣仁,柏子仁,甘草的混合物中,继续浸泡60min,备用;
(3)将浸泡好的原料110℃煎煮至水沸腾后降温至90℃,煎煮50min,过滤得到第一次的药剂和药渣,备用;
(4)向药渣中加入水,110℃煎煮至水沸腾后降温至85℃,煎煮55min,过滤得到第二次的药剂;
(5)将第一次的药剂和第二次的药剂混合后即得治疗骨癌的中药组合物,分两天服用,每日三次,早饭后一小时至一小时半服药,剂量为120-150毫升;中午饭后一小时半服药,剂量为120毫升;晚饭后一小时半服药,剂量为120-150毫升。
临床试验
经由白鼠短期喂养试验和急性毒性实验已确定,本发明所制备的治疗骨癌的中药组合物能有效的抑制大鼠病变细胞的生长和繁殖,由此可见,本发明通过原料之间的相互配合实现了治疗胃癌的效果,以下通过具体病例进一步证明本发明的作用效果:
病例一:多发骨恶性病变(骨癌)
患者某,女,73岁,河北省邯钢医院职工家属。
初诊:1998年3月1日。
主诉:患者于1998年2月27日到邯钢医院做ECT全身骨显像,显示所见:“胸8-9椎体、腰椎3-4椎体处踪剂分布异常浓聚”。诊断为“多发骨恶性病变”。患者要求中医治疗。
证候:形体消瘦,面色苍白,卧床呻吟,大小便不能自理,彻背顿痛(夜间尤为明显)、不定时抽搐、麻木,厌食,胸闷,咳嗽,失眠,舌下静脉曲张,舌淡苔薄白,脉弱而弦细(有陈旧性肺结核病史和风湿病史)。
辨证:肝肾阴亏,津液暗耗,蕴毒阻络。
治疗:益气养阴、滋补肾髓,软坚解毒,化瘀通络。
服用本发明实施例1制备的中药组合物40余天后,患者的上述症状基本消除,患者已能下床行走,大小便自理,活动自如。于1998年4月20日再次到邯钢医院做ECT全身骨显像,ECT图像所见和2月27日骨显像相比,腰椎异常放射性浓聚区基本消失。腰椎3-4骨活性已基本正常。
病例二:
杨某,男、57岁,山西某学院副教授,于2012年5月14日前来就诊。
主诉:患者于2011年12月16日,本单位体检无意中查出“右肺占位”遂行CT检查示“右肺占位”。于2011年12月26日住进北京中国人民解放军总医院(三0一医院),随即进行全身系列检查。
于2011年12月28日----2012年1月12日检查所示:
2011年12月28日行CT引导下肺穿刺病理示:(右肺)中—低分化腺癌,免疫组化染色显示肿瘤细胞:CK(+)TTF-1(+)CK(+)。完善CT、PET、核磁检查诊断为(1)右肺中叶中—低分化腺癌伴右肺门淋巴结转移。(2)右侧额骨、左侧第10后肋骨转移不除外(3)副鼻窦炎(4)肝脏多发囊肿。于2012年1月8日、2012年1月29日、2012年2月23日、2012年3月15日行4次全身化疗,方案为多西他赛+顺铂。
经多方面的治疗直至2012年4月1日出院时的最后诊断:
1、右肺中叶中—低分化腺癌伴右肺门淋巴结转移、右侧额骨、左侧第10后肋转移(T2N1M1bIV期)
2、副鼻窦炎;
3、肝脏多发囊肿
于2012年5月16日转为中医中药治疗:
症候:形体适中,面色臃肿,轻度咳嗽,痰液增多,胸疼气短,后背酸困、轻度眩晕、全身乏力、下肢发冷、无眠、口干舌燥、舌淡苔薄白、脉沉迟而弦,有(陈旧性)肺结核病史(嗜酒史)。
辩证:肺肾两虚、津液暗耗、肝滞气瘀、气血双亏。
治则:润肺补肾、散结化瘀、蔬肝通络、益气补血。
经三个月,服用本发明实施例2所制备的中药组合物45副后。于2012年8月16日在长治医学院附属和平医院做ECT检查。图像所见:
静注示踪迹后2小时行全身骨相像。骨显影清晰。右额骨轻度放射性浓聚。胸骨放射性正常分布。脊柱放射性分布均匀。两侧胸锁关节、锁骨、肩胛放射性基本对称。左侧第10后肋放射性浓聚。骨盆放射性对称。扫描视野内四肢长骨放射性正常分布。双肾显影。
检查结论:右额骨、左侧第10后肋放射性浓聚,不除外骨转移性病变;建议:定期复查3个月。
对以上病症的存在,继续服用三个月,本发明实施例2所制备的中药组合物45副后,又于2012年11月22日在长治医学院附属和平医院做ECT检查全身骨扫描。检查方法及所见:
静脉注射骨代谢显像剂后3小时,行前、后位全身骨骼平面显像:颅骨、脊椎骨、胸廓、盆骨、四肢长骨诸骨骼及骨关节显影清晰,左侧第10后肋可见局限性点状放射性浓聚影。双肾及膀胱显影。
诊断意见:1、左侧第10肋骨血运丰富(与2012年8月16日照片比较略有好转)未见新病灶。2、建议:定期检查。
经长期治疗,患者的上述症状有所减轻,经各项检查指数显示略有好转。
Claims (7)
1.一种治疗骨癌的中药组合物,其特征在于,以重量份计,包括以下组分:黄芪20-30份,杜仲炭15-25份,菟丝子20-30份,天麻20-30份,太子参15-25份,玉竹参15-25份,赤芍15-25份,白芍15-25份,白芨20-30份,石斛15-25份,麦冬15-25份,沙参15-25份,桃仁15-20份,知母15-20份,白花蛇舌草20-30份,桑寄生15-25份,怀牛膝15-25份,延胡索15-25份,宣木瓜15-25份,蛤蚧一对,蚯蚓15-25份,白僵蚕15-25份,瓜蒌15-25份,川贝母15-25份,黄精15-25份,牡丹皮15-25份,鹿角霜20-30份,鸡血藤25-35份,忍冬藤25-35份,酸枣仁20-30份,柏子仁20-30份及甘草10-20份;
还包括龟板25-35份,鳖甲25-35份。
2.根据权利要求1所述的一种治疗骨癌的中药组合物,其特征在于,所述酸枣仁为炒制酸枣仁,所述柏子仁为炒制柏子仁。
3.一种治疗骨癌的中药组合物的制备方法,其特征在于,包括以下步骤:
(1)按权利要求1-2任一项所述的重量份数称取各原料;
(2)将煎煮后的龟板、鳖甲加入至经过浸泡后的余下原料中,继续浸泡,备用;
(3)将浸泡好的原料煎煮,过滤得到第一次的药剂和药渣,备用;
(4)向药渣中加入水,再次煎煮,过滤得到第二次的药剂;
(5)将第一次的药剂和第二次的药剂混合后即得所述治疗骨癌的中药组合物。
4.根据权利要求3所述的一种治疗骨癌的中药组合物的制备方法,其特征在于,步骤(2)中所述龟板、鳖甲的煎煮方式为98-120℃煎煮20-30min。
5.根据权利要求3所述的一种治疗骨癌的中药组合物的制备方法,其特征在于,步骤(2)中所述经过浸泡后的余下原料为经过0-5℃浸泡60-90min后的原料。
6.根据权利要求3所述的一种治疗骨癌的中药组合物的制备方法,其特征在于,步骤(2)中所述继续浸泡为继续浸泡60-90min。
7.根据权利要求3所述的一种治疗骨癌的中药组合物的制备方法,其特征在于,步骤(3)和/或步骤(4)中所述的煎煮为100-120℃煎煮至水沸腾后降温至85-100℃,煎煮45-55min。
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