CN109078079B - Traditional Chinese medicine for treating malignant tumor bone metastasis - Google Patents
Traditional Chinese medicine for treating malignant tumor bone metastasis Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine for treating malignant tumor bone metastasis, which can effectively solve the medication problem of malignant tumor bone metastasis and adopts the technical scheme that the traditional Chinese medicine is prepared from the following raw material medicines by weight: the Chinese medicinal composition is scientific and reasonable in compatibility, rich in raw materials, convenient to take and good in effect, has the effects of tonifying kidney and replenishing essence, detoxifying and protecting bone, is effectively used for treating malignant tumor bone metastasis, and is an innovation in medicaments for treating malignant tumor bone metastasis.
Description
Technical Field
The invention relates to the field of medicines, in particular to a traditional Chinese medicine for treating malignant tumor bone metastasis.
Background
The malignant tumor bone metastasis is a systemic disease, and different treatment schemes are selected according to different stages of disease conditions whether the operation is performed or not. The bone is one of the most common metastatic sites of malignant tumor, because the bone has unique anatomical and physiological pathological conditions, when tumor cells form bone metastasis in bone tissues, the bone can be damaged, the bone strength is reduced, further, bone pain, pathological fracture, nerve compression, hypercalcemia and the like occur, and finally, the life quality of patients is reduced. About 90% of patients with bone metastases suffer from pain, and even after surgical treatment, 50% die from severe pain. In clinic, the application of radiotherapy and analgesic drugs, osteolysis inhibitor and other methods have certain curative effect on malignant tumor bone metastasis, but have great toxic and side effects and poor long-term curative effect. The malignant tumor develops to the bone metastasis stage, which belongs to the terminal stage of the disease, and the patients have poor constitution and high psychopsychological stress, and the common treatment means for the disease mentioned in the guidelines have serious toxic and side effects and poor long-term curative effect, so that the patients are forced to abandon the treatment. Therefore, improvement and innovation of the medicine for treating the bone metastasis of the malignant tumor are imperative.
Disclosure of Invention
In view of the above situation, the present invention aims to provide a Chinese medicine for treating malignant tumor bone metastasis, which can effectively solve the problem of administration of malignant tumor bone metastasis.
The traditional Chinese medicine considers that 'kidney deficiency is the basis and phlegm and blood stasis are combined' to be the basic pathogenesis of bone metastasis of malignant tumor, and 'healthy qi deficiency and pathogenic excess' are the key points of disease recurrence and metastasis. The malignant tumor bone metastasis has the pathogenesis characteristics of kidney essence deficiency, bone malnutrition and phlegm stagnation and obstruction. Accordingly, the technical scheme of the invention is that the traditional Chinese medicine is prepared from the following raw material medicines by weight: 10-20g of semen cuscutae, 10-20g of parasitic loranthus, 8-16g of salted eucommia bark, 8-16g of teasel root, 10-20g of cistanche, 8-16g of prepared rehmannia root, 10-20g of garden balsam stem, 10-20g of fructus psoraleae, 10-20g of rhizoma drynariae, 6-12g of achyranthes aspera, 6-12g of semen brassicae and 10-20g of radix angelicae pubescentis, wherein the semen cuscutae, the cistanche, the garden balsam stem, the fructus psoraleae and the radix angelicae pubescentis are crushed, 70% ethanol with mass concentration of 4-6 times of the semen cuscutae, the cistanche, the lopseed of garden balsam, the fructus psoraleae and the radix angelicae pubescentis is added for percolation, and the percolation is carried out at 50 ℃, the percolation is carried out, the relative density is 1.20, 5 times of the dregs of the semen cuscutae, the herba cistanches, the speranskiae, the fructus psorale, each time is 1.5 hours, the decoction liquids obtained in 2 times are combined, the reduced pressure concentration is carried out at 50 ℃ to obtain an extract with the relative density of 1.22, the extracts obtained in 2 times are combined, then sugar powder and dextrin are added according to the weight ratio of 3:3:1, finally 90% ethanol with the mass concentration of 1-3% of the weight of the extract is added and mixed uniformly to prepare a soft material, the soft material is sieved by a 20-mesh sieve for granulation, the drying is carried out at 60 ℃, the granulation is sieved by a 14-mesh sieve for granulation, and the split charging is carried.
The invention has scientific and reasonable compatibility, rich raw materials, convenient taking and good effect, has the effects of tonifying the kidney, replenishing essence, detoxifying and protecting the bone, is effectively used for treating the bone metastasis of malignant tumors, and is an innovation on medicaments for treating the bone metastasis of the malignant tumors.
Detailed Description
The following examples further illustrate the embodiments of the present invention in detail.
Example 1
When the invention is implemented, the invention can be prepared by the following raw material medicaments by weight: 11g of dodder, 19g of loranthus parasiticus, 9g of salted eucommia bark, 15g of teasel root, 11g of cistanche, 15g of prepared rehmannia root, 11g of garden balsam stem, 19g of malaytea scurfpea fruit, 11g of drynaria rhizome, 11g of achyranthes aspera, 7g of white mustard seed and 19g of pubescent angelica root, wherein the dodder, the cistanche, the garden balsam stem, the malaytea scurfpea fruit and the pubescent angelica root are crushed, 70 percent of ethanol with the mass concentration of 4 times of the dodder, the cistanche, the garden balsam stem, the malaytea scurfpea fruit and the pubescent angelica root is added for percolation, and the mixture is decompressed and concentrated into an extract with the relative density of 1.20 at the temperature of 50 ℃, the dregs of the 5 medicines of the dodder, the cistanche, the garden balsam stem, the malaytea scurfpea fruit and the pubescent angelica root are combined together with 7 times of the loranthus parasiticus, the salted eucommia bark, the dipsacus root, mixing the extracts obtained by 2 times, adding sugar powder and dextrin at a weight ratio of 3:3:1, adding 90% ethanol with a mass concentration of 1% of the extract weight, mixing to obtain soft material, sieving with 20 mesh sieve, granulating, drying at 60 deg.C, sieving with 14 mesh sieve, granulating, and packaging.
Example 2
When the invention is implemented, the invention can also be prepared from the following raw material medicaments in part by weight: 15g of dodder, 15g of loranthus parasiticus, 12g of salted eucommia bark, 12g of teasel root, 15g of cistanche, 12g of prepared rehmannia root, 15g of garden balsam stem, 15g of malaytea scurfpea fruit, 15g of rhizoma drynariae, 9g of achyranthes aspera, 9g of white mustard seed and 15g of pubescent angelica root, the dodder, the cistanche, the garden balsam stem, the malaytea scurfpea fruit and the pubescent angelica root are crushed, 70 percent of ethanol with the mass concentration of 5 times of the dodder, the cistanche, the garden balsam stem, the malaytea scurfpea fruit and the pubescent angelica root is added for percolation, the mixture is decompressed and concentrated into extract with the relative density of 1.20 at 50 ℃, the dregs of the 5 medicines of the dodder, the cistanche, the garden balsam stem, the malaytea scurfpea fruit and the pubescent angelica root are combined with 7 medicines of the loranthus parasiticus, the salted eucommia bark, the teasel root, the prepared rehmannia root, the rhizoma drynariae, mixing the extracts obtained by 2 times, adding sugar powder and dextrin at a weight ratio of 3:3:1, adding 90% ethanol with a mass concentration of 2% of the extract weight, mixing to obtain soft material, sieving with 20 mesh sieve, granulating, drying at 60 deg.C, sieving with 14 mesh sieve, granulating, and packaging.
Example 3
When the invention is implemented, the invention can also be prepared from the following raw material medicaments in part by weight: 19g of semen cuscutae, 11g of parasitic loranthus, 15g of salted eucommia bark, 9g of teasel root, 19g of cistanche, 9g of prepared rehmannia root, 19g of garden balsam stem, 11g of malaytea scurfpea fruit, 19g of drynaria rhizome, 7g of achyranthes aspera, 11g of white mustard seed and 11g of pubescent angelica root, wherein the semen cuscutae, the cistanche, the garden balsam stem, the malaytea scurfpea fruit and the pubescent angelica root are crushed, 70 percent of ethanol with the mass concentration of 6 times of the amount of the semen cuscutae, the cistanche, the garden balsam stem, the malaytea scurfpea fruit and the pubescent angelica root is added for percolation, and the percolation is carried out at 50 ℃, the mixture is decompressed and concentrated into extract with the relative density of 1.20, the dregs of the 5 medicines of the semen cuscutae, the cistanche, the garden balsam stem, the malaytea scurfpea fruit and the pubescent angelica root are combined together with 7 medicines of the parasitic loranthus, the salted eucommia bark, mixing the extracts obtained by 2 times, adding sugar powder and dextrin at a weight ratio of 3:3:1, adding 90% ethanol with a mass concentration of 3% of the extract weight, mixing to obtain soft material, sieving with 20 mesh sieve, granulating, drying at 60 deg.C, sieving with 14 mesh sieve, granulating, and packaging.
The treatment of the invention takes 'tonifying kidney and replenishing essence, detoxifying and protecting bone' as the treatment principle. In the formula, the dodder is sweet and warm, enters liver, kidney and spleen channels, is warm but not hot, tonifies but not dry, and tonifies kidney and essence, thereby being a good medicine for balancing yin and yang; sang Ji Sheng is bitter, sweet and neutral, enters liver and kidney meridians, tonifies liver and kidney, strengthens bones and muscles, and is the monarch drug together with Tu Si Zi. Eucommia bark, cortex eucommiae, sweet and warm in nature, enters liver and kidney meridians, tonifies kidney yang, benefits kidney yin, moistens liver dryness and strengthens tendons and bones, and is the essential medicine for treating soreness and pain of waist and knees and tendons and bones by tonifying liver and kidney; teasel root, bitter and pungent in flavor and slightly warm in nature, enters liver and kidney meridians, can tonify liver and kidney, strengthen tendons and bones, reunite bones, cure wound and relieve pain, and is an essential medicine for orthopedics; eucommia bark is good at tonifying and nourishing but not walking, teasel root is good at activating blood and tonifying but walking, and the eucommia bark and the teasel root are compatible, so that the efficacy of the medicine is doubled, and the tonifying is not stagnated; cistanchis herba is sweet, salty and warm, enters kidney and large intestine channels, is warm but not hot, tonifies but not greasy, and is a good medicine for tonifying kidney yang and benefiting essence and blood; prepared rehmannia root, radix rehmanniae is sweet and slightly warm, enters liver and kidney meridians, and is good at nourishing yin of liver and kidney, so that the prepared rehmannia root, radix rehmanniae preparata, sweet in taste and slightly warm in nature, is an essential drug for treating liver and kidney yin deficiency; the yang-tonifying cistanche is combined with yin-nourishing prepared rehmannia root, so that yang can be assisted by yin and can be biochemically transformed infinitely, the effect of 'seeking yang from yin' is shown as the best, and the cistanche, the eucommia bark and the teasel root are used as ministerial medicaments together. The fructus psoraleae is pungent, bitter and warm, enters spleen and kidney channels, tonifies kidney yang and strengthens kidney essence; the bitter, sweet and warm drynaria rhizome, which belongs to liver and kidney channels, warms and tonifies kidney yang, strengthens muscles and bones, treats wound and relieves pain, is an important medicine for traumatology; the garden balsam stem is pungent and warm, enters liver and kidney channels, warms tendons and penetrates bones, dehumidifies and relieves pain, and carries medicine into bones and muscles to serve as a bone channel-inducing medicine; the achyranthes aspera is slightly bitter and sour, and has the effects of promoting blood circulation to remove blood stasis, eliminating dampness and detoxifying; the white meson is pungent and warm, eliminates phlegm and stagnation, and clears collaterals to relieve pain; fructus Psoraleae, rhizoma Drynariae, herba Speranskiae Tuberculatae, radix Achyranthis and semen Sinapis Albae as adjuvant drugs. Du Huo is pungent, bitter and warm in property, enters kidney meridian, dispels wind-damp and relieves arthralgia, and is the key herb for treating wind-damp arthralgia, acting as a guiding drug. The medicines are combined to play the effects of tonifying the kidney, replenishing essence, detoxifying and protecting bones. The traditional Chinese medicine composition is effectively used for treating malignant tumor bone metastasis, has obvious curative effect through clinical tests and use, and is fully proved by clinical data, and the relevant clinical data are as follows:
1. criteria for selecting cases
Patients with malignant tumor bone metastasis are accompanied by moderate and severe bone pain.
2. Diagnostic criteria
The malignant tumor patients diagnosed by pathology or cytology are confirmed to be bone metastases and have moderate and severe bone pain through CT, MRI, whole body bone scanning, PET-CT and pathological biopsy. The analgesic effect is evaluated by adopting the current international universal standard, namely a pain digital grading method (NRS), wherein the NRS represents no pain to the most pain from 0 to 10, 0 represents 'no pain', 10 represents 'most severe pain', and 1 digit is selected by a patient before and after the treatment to represent the pain intensity of the patient when the patient is graded. Wherein 1-3 are mild pains; 4-6 are moderate pain; 7-10 of severe pain.
3. Exclusion criteria
Pregnant or lactating women; patients with psychotic disorders; those with speech expression disorder and lacking judgment ability for their own symptoms; allergic constitution, or known to be allergic to the composition; combined with serious primary diseases of heart, liver, lung, kidney and hematopoietic system.
4. Treatment regimens
The treatment group orally takes the bone-protecting and detoxifying granules every day, 1 time respectively in the morning and evening, 1-2 bags each time, 5g in each bag, and a cycle of every 4 weeks, and gives conventional symptomatic treatment according to the disease condition, the treatment time is three cycles, and the treatment effect is comprehensively reviewed and evaluated after the treatment is finished.
5. Criteria for efficacy assessment
Has obvious effect that the integral pain level is reduced by more than or equal to 2 steps, and the prior analgesic is stopped;
effectively, the integral pain level is reduced by more than or equal to 1 grade difference, and the dosage or the type of the original analgesic is reduced by more than half;
the effect is that the integral level of pain is reduced by less than 1 grade difference or is unchanged or aggravated, and the dosage or the type of the original analgesic is unchanged or is increased.
Effective rate (%) = (effective + effective)/nx100%
6. Statistical treatment
160 patients were treated, with 92 male patients, 68 female patients, age 35-75 years, median age 59.
Statistical analysis was performed on the experimental data using computer SPSS (19.0) statistical analysis software, the count data was examined by X2, and the measurement data were expressed as mean. + -. standard deviation.
160 patients, 22 cases with obvious effect, 124 cases with effect and 14 cases with no effect, and the total effective rate is 91.25%.
No adverse reaction is found in the test, which shows that the invention has safe medication and stable and reliable curative effect.
To illustrate the treatment in more detail, typical cases and the efficacy of the treatment are given below:
typical cases are:
kaifeng person, li XX, male, 65 years old, lung cancer bone metastasis, cancer pain score: 7 minutes. When 60mg of oxycodone hydrochloride sustained-release tablets and Q12H are orally taken, explosive pain still occurs, and nausea, vomiting, constipation and weakness of the whole body are accompanied. After the bone-protecting detoxifying particles are used for treatment for 1 week, no explosive pain occurs, the oxycodone hydrochloride sustained-release tablets are changed into 40mg, Q12H is changed, the oxycodone hydrochloride sustained-release tablets are changed into 20mg, Q12H is changed after 2 weeks, and the grading of cancer pain is as follows: and 3 minutes. The symptoms of weakness, nausea, vomiting, constipation and the like of the whole body are obviously relieved earlier.
7. Conclusion
The situation shows that the Chinese medicinal composition is an effective medicament for treating the bone metastasis of the malignant tumor, has the effects of tonifying kidney and replenishing essence, detoxifying and protecting bone by combining the medicaments, has no toxic or side effect, stable curative effect, safety, reliability, convenient administration and good effect, is an innovation in medicaments for treating the bone metastasis of the malignant tumor, and has practical clinical significance.
Claims (4)
1. The traditional Chinese medicine for treating malignant tumor bone metastasis bone pain is characterized by being prepared from the following raw material medicines in parts by weight: 10-20g of semen cuscutae, 10-20g of parasitic loranthus, 8-16g of salted eucommia bark, 8-16g of teasel root, 10-20g of cistanche, 8-16g of prepared rehmannia root, 10-20g of garden balsam stem, 10-20g of fructus psoraleae, 10-20g of rhizoma drynariae, 6-12g of achyranthes aspera, 6-12g of semen brassicae and 10-20g of radix angelicae pubescentis, wherein the semen cuscutae, the cistanche, the garden balsam stem, the fructus psoraleae and the radix angelicae pubescentis are crushed, 70% ethanol with mass concentration of 4-6 times of the semen cuscutae, the cistanche, the lopseed of garden balsam, the fructus psoraleae and the radix angelicae pubescentis is added for percolation, and the percolation is carried out at 50 ℃, the percolation is carried out, the relative density is 1.20, 5 times of the dregs of the semen cuscutae, the herba cistanches, the speranskiae, the fructus psorale, each time is 1.5 hours, the decoction liquids obtained in 2 times are combined, the reduced pressure concentration is carried out at 50 ℃ to obtain an extract with the relative density of 1.22, the extracts obtained in 2 times are combined, then sugar powder and dextrin are added according to the weight ratio of 3:3:1, finally 90% ethanol with the mass concentration of 1-3% of the weight of the extract is added and mixed uniformly to prepare a soft material, the soft material is sieved by a 20-mesh sieve for granulation, the drying is carried out at 60 ℃, the granulation is sieved by a 14-mesh sieve for granulation, and the split charging is carried.
2. The traditional Chinese medicine for treating malignant tumor bone metastasis bone pain according to claim 1, which is prepared from the following raw material medicines in parts by weight: 11g of dodder, 19g of loranthus parasiticus, 9g of salted eucommia bark, 15g of teasel root, 11g of cistanche, 15g of prepared rehmannia root, 11g of garden balsam stem, 19g of malaytea scurfpea fruit, 11g of drynaria rhizome, 11g of achyranthes aspera, 7g of white mustard seed and 19g of pubescent angelica root, wherein the dodder, the cistanche, the garden balsam stem, the malaytea scurfpea fruit and the pubescent angelica root are crushed, 70 percent of ethanol with the mass concentration of 4 times of the dodder, the cistanche, the garden balsam stem, the malaytea scurfpea fruit and the pubescent angelica root is added for percolation, and the mixture is decompressed and concentrated into an extract with the relative density of 1.20 at the temperature of 50 ℃, the dregs of the 5 medicines of the dodder, the cistanche, the garden balsam stem, the malaytea scurfpea fruit and the pubescent angelica root are combined together with 7 times of the loranthus parasiticus, the salted eucommia bark, the dipsacus root, mixing the extracts obtained by 2 times, adding sugar powder and dextrin at a weight ratio of 3:3:1, adding 90% ethanol with a mass concentration of 1% of the extract weight, mixing to obtain soft material, sieving with 20 mesh sieve, granulating, drying at 60 deg.C, sieving with 14 mesh sieve, granulating, and packaging.
3. The traditional Chinese medicine for treating malignant tumor bone metastasis bone pain according to claim 1, which is prepared from the following raw material medicines in parts by weight: 15g of dodder, 15g of loranthus parasiticus, 12g of salted eucommia bark, 12g of teasel root, 15g of cistanche, 12g of prepared rehmannia root, 15g of garden balsam stem, 15g of malaytea scurfpea fruit, 15g of rhizoma drynariae, 9g of achyranthes aspera, 9g of white mustard seed and 15g of pubescent angelica root, the dodder, the cistanche, the garden balsam stem, the malaytea scurfpea fruit and the pubescent angelica root are crushed, 70 percent of ethanol with the mass concentration of 5 times of the dodder, the cistanche, the garden balsam stem, the malaytea scurfpea fruit and the pubescent angelica root is added for percolation, the mixture is decompressed and concentrated into extract with the relative density of 1.20 at 50 ℃, the dregs of the 5 medicines of the dodder, the cistanche, the garden balsam stem, the malaytea scurfpea fruit and the pubescent angelica root are combined with 7 medicines of the loranthus parasiticus, the salted eucommia bark, the teasel root, the prepared rehmannia root, the rhizoma drynariae, mixing the extracts obtained by 2 times, adding sugar powder and dextrin at a weight ratio of 3:3:1, adding 90% ethanol with a mass concentration of 2% of the extract weight, mixing to obtain soft material, sieving with 20 mesh sieve, granulating, drying at 60 deg.C, sieving with 14 mesh sieve, granulating, and packaging.
4. The traditional Chinese medicine for treating malignant tumor bone metastasis bone pain according to claim 1, which is prepared from the following raw material medicines in parts by weight: 19g of semen cuscutae, 11g of parasitic loranthus, 15g of salted eucommia bark, 9g of teasel root, 19g of cistanche, 9g of prepared rehmannia root, 19g of garden balsam stem, 11g of malaytea scurfpea fruit, 19g of drynaria rhizome, 7g of achyranthes aspera, 11g of white mustard seed and 11g of pubescent angelica root, wherein the semen cuscutae, the cistanche, the garden balsam stem, the malaytea scurfpea fruit and the pubescent angelica root are crushed, 70 percent of ethanol with the mass concentration of 6 times of the amount of the semen cuscutae, the cistanche, the garden balsam stem, the malaytea scurfpea fruit and the pubescent angelica root is added for percolation, and the percolation is carried out at 50 ℃, the mixture is decompressed and concentrated into extract with the relative density of 1.20, the dregs of the 5 medicines of the semen cuscutae, the cistanche, the garden balsam stem, the malaytea scurfpea fruit and the pubescent angelica root are combined together with 7 medicines of the parasitic loranthus, the salted eucommia bark, mixing the extracts obtained by 2 times, adding sugar powder and dextrin at a weight ratio of 3:3:1, adding 90% ethanol with a mass concentration of 3% of the extract weight, mixing to obtain soft material, sieving with 20 mesh sieve, granulating, drying at 60 deg.C, sieving with 14 mesh sieve, granulating, and packaging.
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Non-Patent Citations (4)
| Title |
|---|
| Mechanisms of cancer metastasis to the bone;Juan Juan YIN et al.;《Cell Research》;20050131;第15卷(第1期);第57-62页 * |
| 益肾化痰法治疗癌症骨转移疼痛经验;王祥麒等;《中医研究》;20101031;第23卷(第10期);第67-68页，尤其是第67页右侧第3-5行 * |
| 补肾壮骨中药合博宁治疗骨转移癌15例;李广诚等;《湖南中医杂志》;20070331;第23卷(第2期);第52、60页，尤其是第52页左侧倒数第1-5、8-11行 * |
| 补肾壮骨法治疗乳腺癌骨转移的临床研究;冯宇等;《中华中医药学刊》;20120630;第30卷(第6期);第1412-1414页，尤其是第1413页左侧倒数第9-14行 * |
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