CN109073639B - 具有异源表位和/或改变的成熟切割位点的流感血凝素的组合物 - Google Patents

具有异源表位和/或改变的成熟切割位点的流感血凝素的组合物 Download PDF

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CN109073639B
CN109073639B CN201780018856.3A CN201780018856A CN109073639B CN 109073639 B CN109073639 B CN 109073639B CN 201780018856 A CN201780018856 A CN 201780018856A CN 109073639 B CN109073639 B CN 109073639B
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CN109073639A (zh
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Cg Discovery Inc
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    • H03F1/565—Modifications of input or output impedances, not otherwise provided for using inductive elements
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    • H03F3/00—Amplifiers with only discharge tubes or only semiconductor devices as amplifying elements
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    • H03F3/19—High-frequency amplifiers, e.g. radio frequency amplifiers with semiconductor devices only
    • H03F3/195—High-frequency amplifiers, e.g. radio frequency amplifiers with semiconductor devices only in integrated circuits
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    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04B—TRANSMISSION
    • H04B1/00—Details of transmission systems, not covered by a single one of groups H04B3/00 - H04B13/00; Details of transmission systems not characterised by the medium used for transmission
    • H04B1/005—Details of transmission systems, not covered by a single one of groups H04B3/00 - H04B13/00; Details of transmission systems not characterised by the medium used for transmission adapting radio receivers, transmitters andtransceivers for operation on two or more bands, i.e. frequency ranges
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CN201780018856.3A 2016-02-03 2017-02-02 具有异源表位和/或改变的成熟切割位点的流感血凝素的组合物 Active CN109073639B (zh)

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US201662290894P 2016-02-03 2016-02-03
US62/290,890 2016-02-03
US62/290,894 2016-02-03
PCT/US2017/016251 WO2017136575A1 (en) 2016-02-03 2017-02-02 Compositions of influenza hemagglutinin with heterologous epitopes and/or altered maturation cleavage sites

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EP (1) EP3411712B1 (https=)
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KR102465833B1 (ko) 2017-11-28 2022-11-11 삼성전자주식회사 무선 통신 시스템에서 전력 설정 방법 및 이를 위한 장치
KR102370100B1 (ko) 2019-02-15 2022-03-07 아이디바이오 주식회사 이종 인플루엔자 a 바이러스에 대한 면역/치료반응을 형성하는 신규한 재조합 인플루엔자 바이러스 및 이를 포함하는 유전자 전달체 및 치료백신
CN117534738B (zh) * 2022-07-15 2024-08-09 中山大学·深圳 一种季节性甲型流感通用Mosaic重组抗原及其疫苗和应用
CN116874607B (zh) * 2023-06-09 2024-12-10 山西高等创新研究院 一种h9亚型禽流感重组嵌合疫苗及其制备方法
CN118978590B (zh) * 2024-10-12 2025-01-21 北京溯本源和生物科技有限公司 一种利用重组流感病毒免疫小鼠制备杂交瘤单抗的方法及应用

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1073878A (zh) * 1991-12-11 1993-07-07 美国家用产品公司 用病毒抗原表达特异性免疫原
WO2004034956A2 (de) * 2002-10-16 2004-04-29 TransMIT Gesellschaft für Technologietransfer mbH 8-plasmid methode mit mutiertem ha gen zur herstellung eines influenza-impfstoffes
CN101795709A (zh) * 2007-08-02 2010-08-04 彼昂德瓦克斯医药有限公司 多亚基多表位流感疫苗
CN101857872A (zh) * 2010-04-06 2010-10-13 浙江省医学科学院 甲型流感病毒抗原决定区更换方法
CN102482328A (zh) * 2009-06-24 2012-05-30 麦迪卡格公司 包含血凝素的嵌合流感病毒样颗粒
CN103517713A (zh) * 2011-02-22 2014-01-15 彼昂德瓦克斯医药有限公司 在改善的季节性和大流行性流感疫苗中的多聚体多表位多肽
CN104185476A (zh) * 2011-09-20 2014-12-03 西奈山医学院 流感病毒疫苗及其应用
WO2016205347A1 (en) * 2015-06-16 2016-12-22 Icahn School Of Medicine At Mount Sinai Influenza virus vaccines and uses thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0974660A1 (en) 1998-06-19 2000-01-26 Stichting Instituut voor Dierhouderij en Diergezondheid (ID-DLO) Newcastle disease virus infectious clones, vaccines and diagnostic assays
DE10249294A1 (de) 2002-10-22 2004-05-13 Rohmax Additives Gmbh Stabile Polymerdispersionen und Verfahren zur Herstellung
MX370690B (es) 2008-07-18 2019-12-19 Medicago Inc Epitopo de inmunizacion de nuevo virus de la influenza.
MX2011000668A (es) 2008-07-18 2011-07-29 Id Biomedical Corp Quebec Antigenos quimericos polipeptidicos del virus sincitial respiratorio.
US9393297B2 (en) * 2013-08-03 2016-07-19 Avatar Medical, Llc Influenza hemagglutinin proteins and methods of use thereof

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1073878A (zh) * 1991-12-11 1993-07-07 美国家用产品公司 用病毒抗原表达特异性免疫原
WO2004034956A2 (de) * 2002-10-16 2004-04-29 TransMIT Gesellschaft für Technologietransfer mbH 8-plasmid methode mit mutiertem ha gen zur herstellung eines influenza-impfstoffes
CN101795709A (zh) * 2007-08-02 2010-08-04 彼昂德瓦克斯医药有限公司 多亚基多表位流感疫苗
CN102482328A (zh) * 2009-06-24 2012-05-30 麦迪卡格公司 包含血凝素的嵌合流感病毒样颗粒
CN101857872A (zh) * 2010-04-06 2010-10-13 浙江省医学科学院 甲型流感病毒抗原决定区更换方法
CN103517713A (zh) * 2011-02-22 2014-01-15 彼昂德瓦克斯医药有限公司 在改善的季节性和大流行性流感疫苗中的多聚体多表位多肽
CN104185476A (zh) * 2011-09-20 2014-12-03 西奈山医学院 流感病毒疫苗及其应用
WO2016205347A1 (en) * 2015-06-16 2016-12-22 Icahn School Of Medicine At Mount Sinai Influenza virus vaccines and uses thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Development of a candidate influenza vaccine based on virus-like particles displaying influenza M2e peptide into the immunodominant loop region of hepatitis B core antigen: Insertion of multiple copies of M2e increases immunogenicity and protective efficie;Nikolai V.Ravin, et al.;《Vaccine》;20150429;摘要，第3393-3396页 *
Development of a candidate influenza vaccine based on virus-like particles displaying influenza M2e peptide into the immunodominant region of hepatitis B core antigen: Broad protective efficacy of particles carrying four copies of M2e.;Liudmila M.Tsybalova, et al.;《Vaccine》;20150511;第3398-3406页 *
Globular Head-Displayed Conserved Influenza H1 Hemagglutinin Stalk Epitopes Confer Protection against Heterologous H1N1 Virus.;Miriam Klausberger, et al.;《PLOS ONE》;20160418;第1-21页 *

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