CN109069643A - 药物组合物 - Google Patents
药物组合物 Download PDFInfo
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- CN109069643A CN109069643A CN201780028404.3A CN201780028404A CN109069643A CN 109069643 A CN109069643 A CN 109069643A CN 201780028404 A CN201780028404 A CN 201780028404A CN 109069643 A CN109069643 A CN 109069643A
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- antibody
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- antigen
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- C—CHEMISTRY; METALLURGY
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- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115484931A (zh) * | 2020-03-11 | 2022-12-16 | 西莱克塔生物科技公司 | 与合成纳米载体相关的方法和组合物 |
| CN115776879A (zh) * | 2020-06-29 | 2023-03-10 | 韩兀生物制药股份有限公司 | 抗fcrn抗体制剂 |
| US12194078B2 (en) | 2017-03-11 | 2025-01-14 | Cartesian Therapeutics, Inc. | Methods and compositions related to combined treatment with anti-inflammatories and synthetic nanocarriers comprising an immunosuppressant |
| WO2025056011A1 (zh) * | 2023-09-13 | 2025-03-20 | 正大天晴药业集团股份有限公司 | 包含抗pd-1抗体和第二抗体的药物组合物 |
| US12472167B2 (en) | 2013-05-03 | 2025-11-18 | Cartesian Therapeutics, Inc. | Methods providing a therapeutic macromolecule and synthetic nanocarriers comprising immunosuppressant locally and concomitantly to reduce both Type 1 and Type IV hypersensitivity |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI703158B (zh) | 2015-09-18 | 2020-09-01 | 美商希佛隆公司 | 特異性結合tl1a之抗體 |
| EP3824906A1 (en) | 2016-12-21 | 2021-05-26 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| GB201708655D0 (en) | 2017-05-31 | 2017-07-12 | Ucb Biopharma Sprl | Cell culture methods |
| CA3094934A1 (en) * | 2018-03-23 | 2019-09-26 | AbbVie Deutschland GmbH & Co. KG | Stable aqueous anti-tau antibody formulations |
| MX2021009851A (es) | 2019-02-18 | 2021-09-10 | Lilly Co Eli | Formulacion de anticuerpos terapeuticos. |
| CA3218343A1 (en) * | 2021-05-12 | 2022-11-17 | Anaptysbio, Inc. | Antibody composition |
| WO2023099607A1 (en) | 2021-12-01 | 2023-06-08 | UCB Biopharma SRL | Formulations comprising fab-peg |
| CN119233815A (zh) * | 2022-05-20 | 2024-12-31 | 株式会社大赛璐 | 液态医药组合物 |
| KR20250018382A (ko) | 2022-05-30 | 2025-02-05 | 한올바이오파마주식회사 | 안정성이 향상된 항-FcRn 항체 또는 이의 항원 결합 단편 |
| CN115708810A (zh) * | 2022-11-03 | 2023-02-24 | 浙江新码生物医药有限公司 | 含有抗cd70-药物偶联物的冻干组合物、冻干制剂及其制备方法和用途 |
| CN120882751A (zh) * | 2023-03-08 | 2025-10-31 | 依牧诺万科学有限公司 | 含聚山梨酯赋形剂的高浓度蛋白质制剂及其制备方法 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101124245A (zh) * | 2003-11-12 | 2008-02-13 | 比奥根艾迪克Ma公司 | 新生儿Fc受体(FcRn)-结合多肽变体、二聚体Fc结合蛋白及其相关方法 |
| CN101489587A (zh) * | 2006-05-12 | 2009-07-22 | 伯哈拉特生物技术国际有限公司 | 一种可用作疫苗的组合物 |
| CN101939338A (zh) * | 2008-02-07 | 2011-01-05 | 默沙东公司 | 1b20 pcsk9拮抗剂 |
| CN104364265A (zh) * | 2012-05-14 | 2015-02-18 | Ucb医药有限公司 | 抗FcRn抗体 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE454137T1 (de) * | 2001-07-25 | 2010-01-15 | Facet Biotech Corp | Stabile lyophilisierte pharmazeutische formulierung des igg-antikörpers daclizumab |
| CA2545603A1 (en) * | 2003-11-12 | 2005-05-26 | Biogen Idec Ma Inc. | Neonatal fc receptor (fcrn)-binding polypeptide variants, dimeric fc binding proteins and methods related thereto |
| JO3324B1 (ar) | 2006-04-21 | 2019-03-13 | Amgen Inc | مركبات علاجية مجففة بالتبريد تتعلق بالعصارة الهضمية |
| AR070316A1 (es) * | 2008-02-07 | 2010-03-31 | Merck & Co Inc | Antagonistas de pcsk9 (proproteina subtilisina-kexina tipo 9) |
| WO2010148337A1 (en) * | 2009-06-18 | 2010-12-23 | Wyeth Llc | Lyophilized formulations for small modular immunopharmaceuticals |
| US9072668B2 (en) | 2010-03-09 | 2015-07-07 | Janssen Biotech, Inc. | Non-aqueous high concentration reduced viscosity suspension formulations of antibodies |
| US8788028B2 (en) | 2010-07-28 | 2014-07-22 | Medtronic, Inc. | Parasympathetic stimulation to enhance tachyarrhythmia detection |
| EP2648750B1 (en) | 2010-12-10 | 2017-01-25 | Novartis AG | Antibody formulation |
| US9220776B2 (en) * | 2011-03-31 | 2015-12-29 | Merck Sharp & Dohme Corp. | Stable formulations of antibodies to human programmed death receptor PD-1 and related treatments |
| JOP20200043A1 (ar) | 2011-05-10 | 2017-06-16 | Amgen Inc | طرق معالجة أو منع الاضطرابات المختصة بالكوليسترول |
| CA3204402A1 (en) * | 2012-03-26 | 2013-10-03 | Sanofi | Stable anti-cxcr5 igg4 antibody formulations |
| US9592289B2 (en) * | 2012-03-26 | 2017-03-14 | Sanofi | Stable IgG4 based binding agent formulations |
| US8883979B2 (en) | 2012-08-31 | 2014-11-11 | Bayer Healthcare Llc | Anti-prolactin receptor antibody formulations |
| US8613919B1 (en) | 2012-08-31 | 2013-12-24 | Bayer Healthcare, Llc | High concentration antibody and protein formulations |
| WO2014093206A1 (en) | 2012-12-13 | 2014-06-19 | Merck Sharp & Dohme Corp. | Lyophilized spherical pellets of anti-il-23 antibodies |
| TW201542226A (zh) * | 2014-02-12 | 2015-11-16 | Sanofi Sa | 抗－ｉｌ－４／抗－ｉｌ－１３雙特異性抗體／聚麩胺酸配製物 |
| AU2015332151A1 (en) | 2014-10-18 | 2017-04-27 | Pfizer Inc. | Anti-IL-7R antibody compositions |
| GB201508180D0 (en) | 2015-05-13 | 2015-06-24 | Ucb Biopharma Sprl | Antibodies |
-
2016
- 2016-05-12 GB GBGB1608323.0A patent/GB201608323D0/en not_active Ceased
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2017
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- 2017-05-11 AR ARP170101248A patent/AR108449A1/es not_active Application Discontinuation
- 2017-05-11 KR KR1020187036132A patent/KR102436694B1/ko active Active
- 2017-05-11 CN CN201780028404.3A patent/CN109069643A/zh active Pending
- 2017-05-11 CA CA3022124A patent/CA3022124A1/en active Pending
- 2017-05-11 SG SG11201809229VA patent/SG11201809229VA/en unknown
- 2017-05-11 EP EP17725544.5A patent/EP3454899B1/en active Active
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- 2017-05-11 ES ES17725544T patent/ES2977545T3/es active Active
- 2017-05-11 WO PCT/EP2017/061261 patent/WO2017194646A1/en not_active Ceased
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- 2018-11-08 CL CL2018003178A patent/CL2018003178A1/es unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101124245A (zh) * | 2003-11-12 | 2008-02-13 | 比奥根艾迪克Ma公司 | 新生儿Fc受体(FcRn)-结合多肽变体、二聚体Fc结合蛋白及其相关方法 |
| CN101489587A (zh) * | 2006-05-12 | 2009-07-22 | 伯哈拉特生物技术国际有限公司 | 一种可用作疫苗的组合物 |
| CN101939338A (zh) * | 2008-02-07 | 2011-01-05 | 默沙东公司 | 1b20 pcsk9拮抗剂 |
| CN104364265A (zh) * | 2012-05-14 | 2015-02-18 | Ucb医药有限公司 | 抗FcRn抗体 |
Non-Patent Citations (1)
| Title |
|---|
| SALMAN MUZAMMIL等: "FcRn binding is not sufficient for achieving systemic therapeutic levels of immunoglobulin G after oral delivery of enteric-coated capsules in cynomolgus macaques", 《PHARMA RES PER》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12472167B2 (en) | 2013-05-03 | 2025-11-18 | Cartesian Therapeutics, Inc. | Methods providing a therapeutic macromolecule and synthetic nanocarriers comprising immunosuppressant locally and concomitantly to reduce both Type 1 and Type IV hypersensitivity |
| US12194078B2 (en) | 2017-03-11 | 2025-01-14 | Cartesian Therapeutics, Inc. | Methods and compositions related to combined treatment with anti-inflammatories and synthetic nanocarriers comprising an immunosuppressant |
| CN115484931A (zh) * | 2020-03-11 | 2022-12-16 | 西莱克塔生物科技公司 | 与合成纳米载体相关的方法和组合物 |
| CN115776879A (zh) * | 2020-06-29 | 2023-03-10 | 韩兀生物制药股份有限公司 | 抗fcrn抗体制剂 |
| WO2025056011A1 (zh) * | 2023-09-13 | 2025-03-20 | 正大天晴药业集团股份有限公司 | 包含抗pd-1抗体和第二抗体的药物组合物 |
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| EP3454899C0 (en) | 2024-03-20 |
| KR102436694B1 (ko) | 2022-08-25 |
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| CA3022124A1 (en) | 2017-11-16 |
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| EP3454899A1 (en) | 2019-03-20 |
| EP3454899B1 (en) | 2024-03-20 |
| WO2017194646A1 (en) | 2017-11-16 |
| CO2018011733A2 (es) | 2019-02-08 |
| JP7126454B2 (ja) | 2022-08-26 |
| SG11201809229VA (en) | 2018-11-29 |
| BR112018072264A2 (pt) | 2019-02-12 |
| GB201608323D0 (en) | 2016-06-29 |
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