CN109069396B

CN109069396B - Multi-color toothpaste preparation

Info

Publication number: CN109069396B
Application number: CN201780027915.3A
Authority: CN
Inventors: 吉江诚
Original assignee: Lion Corp
Current assignee: Lion Corp
Priority date: 2016-06-29
Filing date: 2017-06-27
Publication date: 2021-11-26
Anticipated expiration: 2037-06-27
Also published as: KR102404937B1; KR20190021193A; WO2018003793A1; JP6848969B2; CN109069396A; MY197966A; JPWO2018003793A1

Abstract

A multicolor toothpaste preparation characterized in that a colored toothpaste composition (I) containing (a) 1 or 2 or more water-insoluble pigments selected from vat dyes, oil-soluble dyes and pigments (except aluminum lakes), and a white toothpaste composition (II) adjacently filled in a container; (B) aluminum lake pigment; (C) and (C) 1 or more selected from (C-1) polyacrylate and alginate, and the white toothpaste composition (II) contains (D) white particles and (C) 1 or more selected from (C-2) polyacrylate and alginate.

Description

Multi-color toothpaste preparation

Technical Field

The present invention relates to a multicolor toothpaste preparation which is excellent in color vividness and gives a vivid and stable multicolor pattern appearance.

Background

As a toothpaste preparation, there is a multi-color toothpaste which is extruded in a stripe pattern or the like when being extruded from a container in view of aesthetic and attractive properties. The combination of colors is generally composed of a white paste portion which is a normal color of the toothpaste composition and a colored paste portion other than white.

Generally, when a toothpaste composition is colored, a water-soluble pigment such as blue No. 1 is often used from the viewpoint of color vividness, but in a multi-color toothpaste preparation extruded in a multi-color pattern such as a stripe from a general tube container or the like, the use of a water-soluble pigment causes color shift and bleeding between toothpaste compositions having different colors, and in order to prevent these problems, it is known to use a water-insoluble pigment, chlorophyll or the like.

However, when a pigment is used, the color is poor in vividness, and the problem is particularly remarkable when the colored portion is a warm color system such as red or yellow. Further, there is a problem that transparency of the colored toothpaste composition is lost and it is difficult to impart a transparent appearance, and there is a difficulty in aesthetic appearance.

Patent document 1 (japanese patent laid-open No. 60-48918) proposes a multicolor toothpaste capable of improving color mixing by using a water-soluble chlorophyll derivative such as copper chlorophyll as a colorant, and patent document 2 (japanese patent laid-open No. 2003-321333) proposes a multicolor toothpaste containing a water-soluble copper compound which exhibits a clear color, high transparency and attractive stripe pattern. Further, patent document 3 (japanese patent laid-open No. 2-72112) proposes a stable toothpaste composition containing impermeable stripes using beta-carotene and chlorophyllin, which are organic pigments, as coloring agents, and patent document 4 (japanese patent laid-open No. 59-231010) proposes a coloring dentifrice containing phthalocyanine-type pigments, which are conjugated pigments having intense colors, in a transparent stripe pattern visible to the naked eye.

Documents of the prior art

Patent document

[ patent document 1 ] Japanese patent laid-open No. Sho 60-48918

[ patent document 2 ] Japanese patent laid-open No. 2003-321333

[ patent document 3 ] Japanese patent laid-open No. Hei 2-72112

[ patent document 4 ] Japanese patent laid-open No. Sho 59-231010

Disclosure of Invention

Problems to be solved by the invention

However, conventional multicolor toothpaste preparations are still unsatisfactory in aesthetic quality and have room for improvement, and therefore, development of a technique for improving color vividness and imparting a clear and stable appearance is desired.

The present invention has been made in view of the above circumstances, and an object thereof is to provide a multicolor toothpaste preparation which is excellent in color vividness, suppresses bleeding over time, and suppresses color mixing, and gives a clear and stable multicolor design appearance.

Means for solving the problems

The present inventors have made intensive studies in order to achieve the above object, and as a result, have found that the above object can be achieved by using a combination of (a) a specific water-insoluble coloring matter and (B) an aluminum lake (aluminum lake) coloring matter as coloring matters of a non-white colored toothpaste composition and a white toothpaste composition which are filled into a container so as to be adjacent to each other and have a multicolor pattern, and further using (C) a specific binder as coloring matters of the colored toothpaste composition, so that the composition is adjacent to the white toothpaste composition containing (D) white particles and (C) the specific binder. That is, in the present invention, a multicolor toothpaste preparation which is excellent in color vividness and gives a clear and stable multicolor design appearance in which bleeding is suppressed even with time and color mixing is suppressed can be obtained by filling a container adjacently without mixing (a) a colored toothpaste composition (I) containing 1 or 2 or more kinds of water-insoluble coloring matter selected from vat dyes, oil-soluble dyes and pigments (except aluminum lakes), (B) aluminum lake coloring matter, (C) (C-1) polyacrylate and/or alginate, and (II) a white toothpaste composition (II) containing (D) white particles, (C) (C-2) polyacrylate and/or alginate, in the container.

In the multicolor toothpaste preparation, improper use of a water-insoluble pigment such as a pigment causes lack of color vividness, and use of a water-soluble pigment causes color shift and color mixing, and therefore, it has been difficult to impart a vivid and stable appearance by preventing bleeding and color mixing while improving color vividness with the conventional technique, but in contrast, in the present invention, the combination of water-insoluble pigments such as the components (a) and (B) unexpectedly causes vivid color of the colored toothpaste composition and a clear contrast in the appearance of a multicolor pattern, and further, the component (C) is used in combination, whereby bleeding between toothpaste compositions is suppressed even after storage, and furthermore, kneading stability can be imparted such that there is no color mixing between toothpaste compositions even after kneading a container with fingers for many times and then extruding. In this case, if the component (B) is used in combination with the component (A), although the color vividness is improved, the problem that the component (A) alone is not seen in the case where the component (A) is used alone such that the color bleeds out or the color is mixed when the component (A) is extruded from the container occurs with the lapse of time, but the combination of the components (C) makes such bleeding and color mixing not occur, and thus a multicolor pattern appearance such as a vivid, clear and stable stripe shape can be given. Thus, in the present invention, the combination of the coloring composition containing the components (A), (B) and (C) ((C-1)) and the white composition containing the components (C) ((C-2)) and (D) exhibits excellent effects.

According to the present invention, even a multicolor toothpaste preparation colored in warm colors such as red, yellow, orange and the like, which is poor in color vividness, can impart a satisfactory vivid color, and further, the transparency of the colored toothpaste composition can be improved to make the boundary between the colored toothpaste composition and an opaque white toothpaste composition clearer, and further improvement of the aesthetic quality can be expected.

Further, patent documents 1 and 2 are water-soluble coloring matters, and patent documents 3 and 4 are color improvement by β -carotene, chlorophyllin, and phthalocyanine-type pigments which are organic pigments, and it cannot be predicted from cited documents 1 to 4 that: the improvement of the color vividness, the suppression of bleeding and color mixing of the multicolor toothpaste preparation by the combined use of the components (A), (B), (C) and (D).

Accordingly, the present invention provides a multicolor toothpaste formulation as described below.

〔1〕

A multicolor toothpaste preparation characterized by comprising a colored toothpaste composition (I) and a white toothpaste composition (II) which are filled in a container so as to be adjacent to each other,

the colored toothpaste composition (I) contains:

(A) 1 or 2 or more water-insoluble pigments selected from vat dyes, oil-soluble dyes and pigments (except aluminum lakes);

(B) aluminum lake pigment;

(C) (C-1) 1 or more selected from the group consisting of polyacrylates and alginates,

the white toothpaste composition (II) contains:

(D) white particles; (C) (C-2) 1 or more selected from the group consisting of polyacrylates and alginates.

〔2〕

The multicolor toothpaste preparation according to [ 1 ], wherein the components (A) and (B) are 1 or 2 or more kinds selected from a red pigment, a yellow pigment and an orange pigment, respectively, and the components (A) and (B) are pigments of the same color or different colors.

〔3〕

The multicolor toothpaste preparation according to [ 1 ] or [ 2 ], wherein the component (A) is 1 or more selected from Red 202 and Red 226.

〔4〕

The multicolor toothpaste preparation according to any one of [ 1 ] to [ 3 ], wherein the component (B) is an aluminum precipitate of 1 or 2 or more kinds of pigments selected from yellow No. 4, yellow No. 203, red No. 218 and red No. 223.

〔5〕

The multicolor toothpaste preparation according to any one of [ 1 ] to [ 4 ], wherein the ratio (A)/(B) of the components (A) and (B) in terms of a mass ratio is 0.2 to 5.

〔6〕

The multicolor toothpaste preparation according to any one of [ 1 ] to [ 5 ], wherein the content of the component (A) is 0.0001 to 0.02% by mass and the content of the component (B) is 0.0001 to 0.005% by mass, based on the entire colored toothpaste composition (I).

〔7〕

The multicolor toothpaste preparation according to any one of [ 1 ] to [ 6 ], wherein the content of the (C-1) component is 0.1 to 1.4% by mass based on the entire colored toothpaste composition (I).

〔8〕

The multicolor toothpaste preparation according to any one of [ 1 ] to [ 7 ], wherein the colored toothpaste composition (I) is transparent.

〔9〕

The multicolor toothpaste preparation according to any one of [ 1 ] to [ 8 ], wherein the colored toothpaste composition (I) further contains a silica-based abrasive 5 to 35% by mass and has a refractive index of 1.43 to 1.45 with respect to the entire colored toothpaste composition (I).

〔10〕

The multicolor toothpaste preparation according to any one of [ 1 ] to [ 9 ], wherein the (D) white particles are a white pigment and a water-insoluble inorganic abrasive.

〔11〕

The multicolor toothpaste preparation according to any one of [ 1 ] to [ 10 ], wherein the colored toothpaste composition (I) and the white toothpaste composition (II) are adjacent in a striped form.

〔12〕

The multicolor toothpaste preparation according to any one of [ 1 ] to [ 11 ], which is filled into a single-tube container having no partition wall inside the container.

Effects of the invention

According to the present invention, there can be provided: a multicolor toothpaste preparation which has excellent color vividness, is suppressed in bleeding over time, and is suppressed in color mixing, and gives a clear and stable multicolor pattern appearance. The present invention further provides a multicolor toothpaste preparation which can improve the clarity of a multicolor pattern by making a colored portion highly transparent and has excellent aesthetic appearance.

Detailed Description

The multicolor toothpaste preparation of the present invention comprises a composition containing (A) 1 or more than 2 water-insoluble pigments selected from vat dyes, oil-soluble dyes and pigments (except aluminum lakes); (B) aluminum lake pigment; (C) (C-1) a polyacrylate and/or alginate colored toothpaste composition (I) with (D) white particles; (C) (C-2) polyacrylate and/or alginate white toothpaste composition (II), non-white colored toothpaste composition (I) and white toothpaste composition (II) are not intermixed but are filled contiguously in the container.

Here, as the multicolor toothpaste preparation, there can be mentioned: stripe-like having 1 or 2 or more adjacent faces to which the aforementioned toothpaste compositions (I) and (II) adjoin, and layer-like having an inner layer (toothpaste composition (II)) adjacent to the inner side of the outer layer (toothpaste composition (I)), and the like.

(A) The water-insoluble pigment is 1 or more than 2 pigments selected from vat dye, oil-soluble dye, and pigment (except aluminum lake). Preferably 1 or 2 or more selected from vat dyes and pigments.

Here, the vat dye is a water-insoluble dye, and has a property of being reduced by sodium hydrosulfite (hydrosulfite) to be water-soluble and being air-oxidized to be an original water-insoluble dye.

Oil-soluble dyes (also known as oil dyes) are water-insoluble dyes that have the property of being soluble in alcohol or oil.

Pigment means powder for coloring, which has the property of being insoluble in water, oil, alcohol.

(A) The color of the water-insoluble coloring matter of component (a) is not particularly limited, and may be warm or cold, and may be the same color or different when 2 or more kinds are used, but warm colors, for example, red, yellow, orange and the like are particularly preferable. In the case of such a warm color system, the color vividness is further improved.

Specific examples of the component (A) include the following water-insoluble dyes, and 1 or 2 or more of these may be used.

Reducing a dye:

red 226, blue 201, blue 204

Oil-soluble dyes:

red No. 223, No. 225, No. 215, No. 218, No. 501, No. 505; orange nos. 201, 206, 403; yellow No. 201, No. 204, No. 404, No. 405; green number 202; blue No. 403

Pigment:

red 220, 221, 228, 202, 203, 204, 206, 207, 208, 404, 405; orange nos. 203, 204, 401; yellow No. 205, No. 401; blue number 404; iron oxide pellet (ferric oxide)

Among them, red 226 as a vat dye and red 202 as a pigment are more preferable from the viewpoint of no bleeding and color.

The content of the water-insoluble coloring matter of component (a) is preferably 0.0001 to 0.02% (by mass%, the same applies hereinafter) and more preferably 0.0005 to 0.01% with respect to the whole colored toothpaste composition (I). As the content is increased, the hue becomes better, and when it is 0.0001% or more, a sufficient hue can be obtained. When the content is 0.02% or less, the color vividness can be sufficiently maintained.

(B) The aluminum lake pigment of the component (A) is an aluminum lake of a water-soluble pigment and an oil-soluble dye, and is water-insoluble. The aluminum lake pigment can be obtained by a known production method, and for example, can be obtained by ionizing a water-soluble pigment and an oil-soluble dye, electrically coupling them with a metal ion as a carrier, and performing an insolubilization treatment.

The color of the aluminum lake pigment of component (B) is not particularly limited, and may be the same color as or different from that of component (a), or may be warm or cold, and when 2 or more kinds are used, the same color or different from that of component (a), but warm colors, for example, red, yellow, orange, and the like are particularly preferable. If the color is a warm color system, the color vividness can be further improved.

Specifically, the aluminum lakes of the water-soluble pigments and oil-soluble dyes described below are exemplified, and 1 or 2 or more of them may be used.

Water-soluble pigment:

red nos. 2, 3, 102, 104, 105, 106, 227, 230, 231, 232, 401, 502, 503, 504, 506; orange nos. 205, 207, 402; yellow nos. 4, 5, 202, 203, 402, 403, 407; green No. 3, No. 201, No. 204, No. 205, No. 402; blue No. 1, No. 2, No. 205

Oil-soluble dyes:

Among these, yellow No. 4 aluminum lake, yellow No. 203 aluminum lake, red No. 218 aluminum lake, and red No. 223 aluminum lake are particularly preferable, and yellow No. 4 aluminum lake and yellow No. 203 aluminum lake are particularly more preferable from the viewpoint of color vividness.

The content of the aluminum lake pigment in the component (B) is preferably 0.0001 to 0.005%, more preferably 0.001 to 0.003%, based on the whole colored toothpaste composition (I). As the content is increased, the hue becomes better, and when it is 0.0001% or more, a sufficient hue can be obtained. If the content is 0.005% or less, bleeding can be sufficiently suppressed.

In the present invention, it is more preferable to combine the components (A) and (B) in a specific ratio. The (A)/(B) ratio, which is the mixing ratio of the components (A) and (B), is preferably 0.2 to 5, more preferably 0.3 to 5, and still more preferably 0.3 to 3.3 in terms of mass ratio. When the amount is within this range, bleeding is further suppressed, and a more vivid color can be imparted. If the amount is less than 0.2, bleeding may occur without being suppressed, and if the amount exceeds 5, vivid colors may not be sufficiently obtained.

(C) The component (A) is selected from 1 or more of polyacrylate and alginate, preferably polyacrylate and alginate. When a polyacrylate salt and/or an alginate salt is mixed as a binder, bleeding is suppressed, and kneading stability is excellent. In addition, if polyacrylate is not used, bleeding may not be suppressed, and if alginate is used, bleeding may not be suppressed, and kneading stability may be poor.

As the polyacrylate and alginate, alkali metal salts thereof, specifically sodium polyacrylate and sodium alginate can be used. Commercially available products manufactured by Tokya synthesis and KIMICA can be used.

The total content of (C) (C-1) polyacrylate and/or alginate is 0.1 to 1.4%, particularly preferably 0.2 to 1.4%, and more preferably 0.4 to 1.0% with respect to the whole colored toothpaste composition (I). Within this range, bleeding can be sufficiently suppressed, and sufficient kneading stability can be obtained.

Further, when the component (C) (component (C-1)) contains a polyacrylate, the content thereof is 0.1 to 1.4%, particularly preferably 0.1 to 0.7%, and more preferably 0.2 to 0.5% of the whole colored toothpaste composition (I). If the content is 0.1% or more, bleeding can be sufficiently suppressed, and if the content is 1.4% or less, sufficient kneading stability is obtained.

In addition, when the alginate is contained, the content thereof is 0.1 to 1.4%, particularly preferably 0.1 to 0.7%, and more preferably 0.2 to 0.5% of the whole colored toothpaste composition (I). If the content is 0.1% or more, sufficient kneading stability can be obtained while sufficiently suppressing bleeding, and if the content is 1.4% or less, the effect of suppressing bleeding can be satisfactorily maintained.

When the polyacrylate and the alginate are used in combination, the mixing ratio thereof is not particularly limited, and is 0.14 to 7, particularly preferably 0.25 to 4 in terms of mass ratio. When the amount is within this range, the bleeding inhibiting effect and the kneading stability are more excellent. If the amount is less than 0.14, bleeding may not be suppressed, and if the amount exceeds 7, kneading stability may be lowered.

In addition, as the binder, substances other than the component (C), for example, gums such as xanthan gum, and cellulose derivatives such as sodium carboxymethyl cellulose may be added within a range not to impair the effects of the present invention, and particularly when sodium carboxymethyl cellulose is added as a cellulose derivative, the addition amount thereof is 0.05% or less, particularly preferably 0.1% or less, of the entire composition, or may not be added (0%).

Examples of the white particles (D) contained in the white toothpaste composition (II) include: (D-1) white pigments such as titanium oxide and zinc oxide; (D-2) calcium compounds such as aluminum hydroxide and calcium carbonate; magnesium compounds such as magnesium carbonate; a zeolite; water-insoluble inorganic abrasives such as anhydrous silicic acid. These may be used in 1 or 2 or more. Further, the component (D-1) or the component (D-2) may be used, but the component (D-1) and the component (D-2) are preferably used in combination, the white pigment and the water-insoluble inorganic abrasive are particularly preferably used in combination, and the titanium oxide and the anhydrous silicic acid are more preferably used in combination.

The content of the white pigment (D-1) is preferably 0.1 to 2%, more preferably 0.2 to 1% of the whole white toothpaste composition (II). The content of the (D-2) abrasive is 5 to 50%, preferably 10 to 45%. If component (D) is within this range, the contrast with the boundary of the colored toothpaste becomes clear, and a clearly striped toothpaste can be obtained. If too much, the surface of the toothpaste may be rough.

The white toothpaste composition (II) contained the component (C), (the polyacrylate and/or alginate (C-2)), and was the same as the component (C-1) of the colored toothpaste composition (I).

When the polyacrylate is contained as the component (C-2), the content thereof is 0.1 to 0.7%, particularly preferably 0.2 to 0.5% of the whole white toothpaste composition (II). In addition, when the alginate is contained, the content is 0.1 to 0.7%, particularly preferably 0.2 to 0.5% of the whole white toothpaste composition (II). Further, the total content of (C-2) polyacrylate and/or alginate is preferably 0.2 to 1.4%, more preferably 0.4 to 1.0%, relative to the whole white toothpaste composition (II). Within this range, the effects of the present invention are more preferably exhibited.

The binder other than the component (C) is the same as described above.

In the present invention, the colored toothpaste composition (I) is preferably translucent or transparent, more preferably transparent, and the white toothpaste composition (II) is translucent or opaque.

By adjusting the refractive index of the colored toothpaste composition (I) to be the same as the refractive index of the abrasive to be mixed (1.43 to 1.45 in the case of a silica-based abrasive), high transparency and a vivid color can be obtained, and the boundary with the adjacent opaque white toothpaste composition (II) can be made clear.

In this case, examples of the abrasive to be mixed in the colored toothpaste composition (I) include silica-based abrasives such as anhydrous silicic acid, aluminosilicate, and zirconium silicate; calcium carbonate-based abrasives, however, are preferred among calcium carbonate-based abrasives because calcium carbonate has a refractive index as high as 1.50 to 1.64, as opposed to a refractive index of about 1.44 for silica-based abrasives, and it is generally difficult to adjust the refractive index in a solvent used in a toothpaste composition. The content of the abrasive, particularly silica-based abrasive, is 5 to 35%, particularly preferably 10 to 25%, based on the whole colored toothpaste composition (I).

In the present invention, when a water-insoluble inorganic abrasive, particularly anhydrous silicic acid, is used as the component (D-2) in the white toothpaste composition (II), and the same silica-based abrasive as that used as the component (D-2) is added to the colored toothpaste composition (I), it is more preferable from the viewpoint of the effect, because the difference in physical properties such as viscosity between the two toothpaste compositions is small and the kneading stability is good.

The refractive index was measured by Abbe refractometer (NAR-1T SOLID, manufactured by ATAGO Co., Ltd.) (the same shall apply hereinafter). Further, the adjustment of the refractive index may be performed by the following method.

Method for adjusting refractive index

Since the refractive index of the toothpaste composition depends on the amount of 1 or 2 or more sugar alcohols, polyols and moisture selected from sorbitol, propylene glycol, polyethylene glycol having an average molecular weight of 280 to 1,050 (average molecular weight described in ministry of medicine and foreign materials standard 2006), the refractive index can be adjusted by the balance of the respective amounts. The amount of polyol is preferably 40 to 70% of the total coloured toothpaste composition (I).

In addition, in the toothpaste composition, the sugar alcohol and the polyol are generally mixed as a thickener, and water is mixed as a liquid medium, and the same can be applied to the present invention.

The multicolor toothpaste preparation of the present invention is particularly preferably used as a toothpaste, and the colored toothpaste composition (I) and the white toothpaste composition (II) may be mixed with the general components of the toothpaste composition as needed, in addition to the above components, within a range not impairing the effect of the present invention. Examples thereof include: surfactant, sweetener, antiseptic, perfume, effective components, etc. The abrasives and the thickener are also the same as those described above for the white toothpaste composition (II).

As the surfactant, an anionic surfactant, a nonionic surfactant, a cationic surfactant, and an amphoteric surfactant, which are generally used, may be mixed in the toothpaste composition.

Examples of the anionic surfactant include alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate; n-acyl sarcosinates such as N-lauroyl sarcosinate sodium; n-acyl glutamate; alpha-olefin sulfonates, and the like.

Examples of the nonionic surfactant include: sugar fatty acid esters such as sucrose fatty acid esters; sugar alcohol fatty acid esters such as maltitol fatty acid esters; sorbitan fatty acid esters; glycerin fatty acid ester; polyglyceryl fatty acid esters; polyoxyethylene sorbitan fatty acid esters; polyoxyethylene hydrogenated castor oil; polyoxyethylene higher alcohol ethers; fatty acid alkanolamides, and the like.

Examples of the cationic surfactant include alkylammonium and alkylbenzylammonium, and examples of the amphoteric surfactant include acetic acid betaine systems such as alkylbetaine and alkyldimethylaminoacetic acid betaine; betaine-based ones such as alkylimidazolinium betaine, imidazoline-based ones.

The amount of the surfactant to be mixed is 0.001 to 10%, particularly preferably 0.01 to 5% of the whole toothpaste composition.

Examples of the sweetener include sodium saccharin and the like, and examples of the preservative include parabens such as methyl paraben and the like, benzoic acid or a salt thereof, and the like.

As the flavor, the following known flavor raw materials used in the oral composition can be used in combination: natural flavors such as peppermint oil (peppermint oil), spearmint oil, anise oil, eucalyptus oil, wintergreen oil, cinnamon oil, clove oil, senecio oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, lime oil (lime oil), lavender oil, rosemary oil, myrcia oil (laurel oil), chamomile oil (chamomile oil), caraway oil (caraway oil), marjoram oil (marjoram oil), bay leaf oil, lemongrass oil, oregano oil, pine needle oil, orange flower oil, rose oil, jasmine oil, grapefruit oil (スウィーティー oil), grapefruit oil, orange oil, iris extractum, peppermint oil, rose absolute, orange flower oil, and the like; and a flavor obtained by processing (removing pre-cut fraction, removing post-cut fraction, fractionating, liquid-liquid extracting, distilling and extracting (stress), powdering and flavoring) these natural flavors; and also monotropic flavors such as menthol, carvone, anethole, cineole, methyl salicylate, cinnamaldehyde, eugenol, 3-l-menthoxypropane-1, 2-diol, thymol, linalool, linalyl acetate, limonene, menthone, menthyl acetate, N-substituted-p-menthane-3-carboxamide, pinene, octanal, citral, pulegone (pulegone), carvoyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allyl cyclohexylpropionate, methyl anthranilate, ethyl methylphenylglycerol, vanillin, undecalactone, hexanal, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, methyl cyclopentenolone, furfural, trimethylpyrazine, ethyl lactate, ethyl thioacetate; and blending flavors such as strawberry flavor essence, apple flavor essence, banana flavor essence, pineapple flavor essence, grape flavor essence, mango flavor essence, butter flavor essence, milk flavor essence, fruit mixed flavor essence, tropical fruit flavor essence, and the like. The perfume raw material is preferably used in an amount of 0.000001 to 1% by weight of the composition. In addition, as the perfume for giving fragrance using the perfume raw material, 0.1 to 2% is preferably used in the composition.

Examples of the active ingredient include fluorides such as sodium fluoride and sodium monofluorophosphate; nonionic bactericides such as isopropyl methylphenol; cationic bactericides such as cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, and the like; anti-inflammatory agents such as tranexamic acid, epsilon-aminocaproic acid, allantoin and the like; enzymes such as dextranase and water-insoluble dextranase; a water-soluble phosphoric acid compound; a water-soluble copper compound; potassium nitrate; aluminum lactate; ascorbic acid or a derivative thereof; vitamins, and the like. The amount of the active ingredient to be mixed is an effective amount within a range not to impair the effects of the present invention.

The multicolor toothpaste preparation of the present invention is prepared by filling a container with the colored toothpaste composition (I) and the white toothpaste composition (II) in a state where they are not mixed, preferably in a stripe form, a spiral form or a dot form, more preferably in a state where they are adjacent to each other in a stripe form, and discharging them from the container while maintaining such a shape. The ratio of the colored toothpaste composition (I) to the white toothpaste composition (II) is not particularly limited, and can be appropriately set to give a desired toothpaste appearance (design). For example, from the viewpoint of the appearance of the multicolor toothpaste preparation, the ratio (I)/(II) is preferably set to 0.1/99.9 to 99.1/0.1 (mass ratio), more preferably set to 10/90 to 90/10, and still more preferably set to a range of 20/80 to 80/20. When the shape is stripe-shaped or spiral, the ratio (I)/(II) is preferably 1/99 to 99/1, more preferably 5/95 to 95/5, still more preferably 10/90 to 90/10, and particularly preferably 20/80 to 80/20. When the shape is a dot shape, the ratio (I)/(II) is preferably 0.1/99.9 to 20/80, more preferably 1/99 to 10/90.

The toothpaste preparation can be produced by a conventional method, and can be obtained by separately producing the colored toothpaste composition (I) and the white toothpaste composition (II) and filling the two compositions into a container. Specifically, it can be manufactured according to the method of the embodiment described below, and the like.

Further, as the filling container, a general container for a toothpaste preparation can be used, and a single tube container without a partition wall inside the container such as a filling portion and a mouth portion can be filled to use as a toothpaste product.

[ examples ] A method for producing a compound

The present invention will be described in more detail with reference to examples and comparative examples, but the present invention is not limited to the examples. In the following examples,% represents mass% unless otherwise specified.

[ examples, comparative examples ]

As shown in tables 1 to 3, after a transparent colored toothpaste composition (I) having a composition shown in tables 1 to 3 and an opaque white toothpaste composition (II) having a composition shown in table 4 were produced by a usual method, the colored toothpaste composition and the white toothpaste composition were transferred to respective hoppers in a filling machine for striped toothpaste, and were filled into a tube container (a general tube container for toothpaste having no partition wall in the container) so as to be adjacent in a striped manner without mixing with each other, thereby obtaining a multicolor toothpaste preparation (test preparation). Colored toothpaste composition (I)/white toothpaste composition (II) ═ 1/1 (mass ratio).

The test preparations were evaluated by the following methods, and the results are shown in tables 1 to 3.

The refractive index was measured by Abbe refractometer (NAR-1T SOLID, manufactured by ATAGO).

< evaluation method of color vividness >

The toothpaste composition from which the test preparation was extruded from the tube container was visually evaluated for the color vividness of the paste when placed on a toothbrush according to the following criteria.

Here, the vividness of the color of the paste indicates the brightness and sharpness of the colored portion.

Criteria for determination

Very good: for clear and bright color

O: slightly lacking in definition, but of vivid color

And (delta): the color is roughly clear but lacks brightness

X: dull color and lack of brightness

< method for evaluating the Presence of bleeding >

After the test preparation was stored at 50 ℃ for 30 days, the bleeding (presence or absence of bleeding) of the paste when the toothpaste composition was extruded from the tube container and placed on a toothbrush was visually judged according to the following criteria.

Criteria for determination

Very good: no color bleeding and clean stripe shape

O: can be seen to bleed a little bit, and the shape of the stripe is maintained

And (delta): color bleeding is visible, the boundaries of the stripes overlap slightly, but the stripe morphology remains

X: color bleeding, unclear boundaries between stripes, and complete mixing

< evaluation method of kneading stability (presence or absence of color mixing) >

The filling amount of the toothpaste composition in the test preparation was set to about half, and after kneading the middle of the tube container 10 times with fingers, the color of the paste when the toothpaste composition was extruded from the tube container and placed on a toothbrush (presence or absence of color mixing) was visually judged according to the following criteria.

Criteria for determination

Very good: no color mixing, and is in the form of clean stripe

O: little color mixing is visible, but the stripe shape is maintained

And (delta): visible color mixing, the boundaries of the stripes slightly overlap, but the stripe morphology remains

X: the boundaries between stripes are not clear and are completely mixed together

Details of the raw materials used are as follows.

(A) D & C Red 7 (Red 202)

Lavanya Indica, NEELIKON K.K

(A) D & C Red 30 (Red No. 226)

Lavanya Roseum manufactured by NEELIKON Inc

(B) D & C Yellow 5 aluminum lake (Yellow No. 4 aluminum lake)

Neelickert FD & C Yellow 5AL Lake, manufactured by NEELIKON Inc

(B) D & C Yellow 10 aluminum lake (Yellow 203 aluminum lake)

Lavanya Mimosa manufactured by NEELIKON Inc

(B) D & C Red 27 aluminum lake (Red 218 aluminum lake)

Lavanya Lilac manufactured by NEELIKON Inc

(B) D & C Red 21 aluminum lake (Red No. 223 aluminum lake)

Lavanya Carlotta, manufactured by NEELIKON Inc

(C) Sodium (C-1), (C-2)) polyacrylate

RHEOGIC 260H manufactured by TOYA SYNTHETIC CO., LTD

(C) Sodium alginate (C-1 and C-2)

KIMICA seaweed gel, manufactured by KIMICA corporation

(D) (D-1) titanium oxide

Titanium oxide available from Shidai industries Ltd

(D) (D-2) Anhydrous silicic acid (abrasive)

Manufactured by PQ Co Ltd

[ TABLE 1 ]

The same evaluation results were obtained even when compositions 2 and 3 shown in table 4 were used for the white toothpaste composition (II).

[ TABLE 2 ]

[ TABLE 3 ]

[ TABLE 4 ]

Claims

1. A multicolor toothpaste preparation characterized by comprising a colored toothpaste composition (I) and a white toothpaste composition (II) which are filled in a container so as to be adjacent to each other,

the colored toothpaste composition (I) contains (A) 1 or 2 or more water-insoluble pigments selected from vat dyes, oil-soluble dyes and pigments, but the water-insoluble pigments do not include aluminum lakes;

(B) aluminum lake pigment;

(C) (C-1) polyacrylate and alginate,

the content of the component (A) is 0.0001-0.02 mass%, the content of the component (B) is 0.0001-0.005 mass%,

the (A)/(B) ratio, which is a mixing ratio of the component (A) to the component (B), is 0.2 to 5 in terms of a mass ratio,

the mixing ratio of the polyacrylate and the alginate is 0.14-7 in terms of mass ratio,

the white toothpaste composition (II) contains (D) white particles and (C) 1 or more selected from (C-2) polyacrylate and alginate.

2. The multicolor toothpaste preparation according to claim 1, wherein the component (A) and the component (B) are each 1 or 2 or more kinds selected from a red pigment, a yellow pigment and an orange pigment, and the component (A) and the component (B) are pigments of the same color or different colors.

3. The multicolor toothpaste formulation according to claim 1 or 2, wherein the component (a) is 1 or more selected from red 202 and red 226.

4. The multicolor toothpaste formulation according to claim 1 or 2, wherein the component (B) is an aluminum lake of 1 or more than 2 kinds of pigments selected from yellow No. 4, yellow No. 203, Red No. 218 and Red No. 223.

5. The multicolor toothpaste formulation according to claim 1 or 2, wherein the content of the (C-1) component is 0.1 to 1.4% by mass relative to the entire colored toothpaste composition (I).

6. The multicolor toothpaste formulation according to claim 1 or 2, wherein the colored toothpaste composition (I) is transparent.

7. The multicolor toothpaste formulation according to claim 1 or 2, wherein the colored toothpaste composition (I) further comprises 5 to 35 mass% of a silica-based abrasive with respect to the entire colored toothpaste composition (I), and the refractive index of the colored toothpaste composition (I) is 1.43 to 1.45.

8. The multicolor toothpaste formulation according to claim 1 or 2, wherein (D) the white particles are a white pigment and a water-insoluble inorganic abrasive.

9. The multicolor toothpaste formulation according to claim 1 or 2, wherein the colored toothpaste composition (I) and the white toothpaste composition (II) are adjacent in stripes.

10. The multicolor toothpaste formulation according to claim 1 or 2 which is filled into a single tube container without a partition wall inside the container.