CN109011206A - Beam diagnostic system for neutron capture treatment system - Google Patents
Beam diagnostic system for neutron capture treatment system Download PDFInfo
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Abstract
One aspect of the present invention is to improve the accuracy of the neutron beam exposure dose of neutron capture treatment system and provides a kind of beam diagnostic system that can be used in neutron capture treatment system to carry out fault diagnosis, a kind of beam diagnostic system for neutron capture treatment system is provided in a technical solution, wherein, neutron capture treatment system includes charged particle beam, for passing through the charged particle beam entrance of charged particle beam, through nuclear reaction occurs to generate the neutron generating unit of neutron beam with charged particle beam, for adjusting the beam-shaping body of the neutron beam flux generated through neutron generating unit and quality and being adjacent to the beam outlet of beam-shaping body, wherein, charged particle beam entrance is contained in beam-shaping body, neutron generating unit is contained in beam-shaping body, beam diagnostic system includes charged particle beam diagnostic device and neutron beam Diagnostic device, beam diagnostic system be used for and meanwhile diagnose neutron capture treatment system and/or beam diagnostic system whether failure.
Description
Technical field
The present invention relates to a kind of beam diagnostic system more particularly to a kind of beam diagnostics for neutron capture treatment system
System.
Background technique
As the radiation cures such as the development of atomics, such as cobalt 60, linear accelerator, electron beam have become cancer
One of the main means of disease treatment.However conventional photonic or electronic therapy are limited by radioactive ray physical condition itself, are being killed
While dead tumour cell, normal tissue a large amount of in beam approach can also be damaged；Additionally, due to tumour cell to putting
The difference of radiation-sensitive degree, traditional radiation therapy is for relatively having the malignant tumour of radiation resistance (such as: multirow glioblast
Tumor (glioblastoma multiforme), melanocytoma (melanoma)) treatment effect it is often bad.
Target therapy in order to reduce the radiation injury of tumour surrounding normal tissue, in chemotherapy (chemotherapy)
Concept is just applied in radiation cure；And it is directed to the tumour cell of radiation resistance, also actively development has high phase at present
To the radiation source of biological effect (relative biological effectiveness, RBE), as proton therapeutic, heavy particle are controlled
Treatment, neutron capture treatment etc..Wherein, neutron capture treatment is to combine above two concept, if boron neutron capture is treated, by
Boracic drug gathers in the specificity of tumour cell, and accurately neutron beam regulates and controls for cooperation, provides more better than conventional radiation
Treatment of cancer selection.
Boron neutron capture treatment (Boron Neutron Capture Therapy, BNCT) be using boracic (10B) drug
There is the characteristic of high capture cross section to thermal neutron, by10B(n,α)7Li neutron capture and nuclear fission reaction generate4He and7Li two
A heavy burden charged particle.Referring to Figures 1 and 2, which respectively show boron neutron capture reaction schematic diagram and10B(n,α)7Li neutron
Nuclear equation formula is captured, the average energy of two charged particles is about 2.33MeV, and there is High Linear to shift (Linear
EnergyTransfer, LET), short range feature, the linear energy transfer of α particle and range are respectively 150keV/ μm, 8 μm,
And7Li heavy burden particle is then 175keV/ μm, 5 μm, and the integrated range of two particle is approximately equivalent to a cell size, therefore for life
Radiation injury caused by object can be confined to cell level, be gathered in tumour cell when boracic drug selectivity, and collocation is suitable
When neutron penetrate source, just can under the premise of normal tissue does not cause too major injury, reach part kill tumour cell mesh
's.
And the beam detection and diagnosis in neutron capture treatment system belongs to a critically important project, this directly concerning
In the dosage and effect of irradiation treatment.The prior art discloses in a kind of neutron capture treatment system, such as by advance to quilt
Irradiation body attaches the spun gold of neutron beam measurement, removes spun gold in the irradiation midway of neutron beam and measures the radiation of the spun gold
Amount, to measure the exposure dose for the neutron beam for irradiating midway.And controlled according to the exposure dose of the measurement (such as stop
Deng) neutron capture treatment system, to make neutron beam expose to irradiated body with exposure dose according to schedule.
If but at this point, for example due to certain reason measurement spun gold radiationization amount after neutron beam exposure dose rate
It is changed, then can not be sufficiently corresponding with this kind variation, and having makes to expose to neutron beam with exposure dose according to schedule
The anxiety that a thing becomes difficult at irradiated body.That is, in above-mentioned neutron capture treatment system, cannot detect in real time
Beamlet exposure dose also can not determine all parts of neutron capture treatment system by detecting and detection device itself is
No failure.
Therefore, it is necessary to propose a kind of accuracy that can be improved neutron beam exposure dose neutron capture treatment system and
It is able to carry out the beam diagnostic system of fault diagnosis.
Summary of the invention
One aspect of the present invention is to improve the accuracy of the neutron beam exposure dose of neutron capture treatment system and mention
For a kind of beam diagnostic system that can be used in neutron capture treatment system to carry out fault diagnosis, mentioned in a technical solution
For a kind of beam diagnostic system for neutron capture treatment system, wherein neutron capture treatment system include charged particle beam,
For passing through the charged particle beam entrance of charged particle beam, through nuclear reaction occurs to generate in neutron beam with charged particle beam
Sub- generating unit, the beam-shaping body for adjusting the neutron beam flux generated through neutron generating unit and quality and it is adjacent to beam
The beam of shaping body exports, wherein charged particle beam entrance is contained in beam-shaping body, and it is whole that neutron generating unit is contained in beam
In body, beam diagnostic system includes charged particle beam diagnostic device and neutron beam diagnostic device, and beam diagnostic system is for same
When diagnosis neutron capture treatment system and/or beam diagnostic system whether failure.Beam diagnostic system passes through while detecting electrification
The particle beams and neutron beam, to improve the accuracy of neutron beam exposure dose.In addition, beam diagnostic system passes through a series of detection
As a result judging that it is abnormal which device in neutron capture treatment system and/or component generate, or judge beam diagnostic
Whether the detection device itself in system is abnormal.It can accomplish to shoot the arrow at the target in this way, improve the accurate of neutron beam exposure dose
Degree, and greatly reduce maintenance time and cost.
Preferably, neutron capture treatment system further comprises for cooling medium to be placed at neutron generating unit with cooling
The cooling device of neutron generating unit and the beam exposure come out through beam exit wait shine body, beam diagnostic system is further
Including learning that cooling device and neutron generating unit generate the temperature detection of neutron beam situation for detecting cooling device temperature
Device and for diagnosing to move the displacement detector that whether moves according to position.Such setting, so that from the source of accelerator
Until being both provided with miscellaneous detection device to the terminal according to body, judge that neutron capture is controlled by these detection devices
The each critical component or detection device for the treatment of system itself are with the presence or absence of abnormal.Preferably as one kind, from the source of accelerator
Detection device is set as the first terminal until wait shine body: being provided with detection device at the vacuum tube at accelerator source,
It is provided with detection device at neutron generating unit, close to neutron generating unit and is used for at the cooling cooling device of neutron generating unit
It is provided with detection device, detection device is provided in beam-shaping body, beam exit is provided with detection device, sets wait shine at body
It is equipped with detection device.
As it is a kind of preferably, neutron capture treatment system further comprises expanding dress for expand charged particle beam
It sets；Charged particle beam diagnostic device further comprises for detecting the charged particle beam located before entering charged particle beam entrance
First current detection means of intensity and stability and intensity for detecting the charged particle beam through acting on neutron generating unit
With the second current detection means of changing condition；Neutron beam diagnostic device further comprise for detect beam-shaping it is intracorporal in
The Strength Changes and spatial distribution of beamlet are embedded in the intracorporal first neutron beam monitoring device of beam-shaping and for detecting beam
The Strength Changes and spatial distribution of the neutron beam in exit, the second neutron beam monitoring device for being embedded in beam exit.
As it is further preferred that the first current detection means be Faraday cup (Faraday cup electrometer),
It, which is that one kind is metal, is designed to cup-shaped, for measuring a kind of vacuum detecting of charged particle beam incident intensity and stability
Device, the electric current measured can be used to determine the quantity of charged particle beam.After charged particle beam enters Faraday cup, it can generate
Electric current.For a continuous singularly charged charged particle beam: being calculated using formula one, wherein N is number of charged particles
It is that electric current (unit is ampere), the e measured is elementary charge (about 1.60 × 10 that amount, t, which are time (unit is the second), I,-19Coulomb).
We can be evaluated whether, if measuring electric current is 10-9A (1nA), i.e., there are about 6,000,000,000 charged particles is collected by Faraday cup.
Certainly, the known ground of those skilled in the art, the first current detection means 100 can be suitable for be arbitrary in accelerator
It is used to measure the detection device of charged particle beam incident intensity and stability at vacuum tube, such as wall current detector (Wall
) and beam transformer (Beam Current Transformer) CurrentMonitor.
Sample resistance is connected across ceramic distance piece both ends by so-called wall current detector, and line image current flows through sampling electricity
It can be obtained voltage sampling signal when resistance, calculated using formula two, wherein V is the voltage value detected, IbFor charged particle
Beam current, Z can be equivalent to resistance under specific frequency, and wall current detector equivalent circuit is Parallel RLC Circuit, such as formula
Three.Therefore electric current of the charged particle beam in certain time period t can be extrapolated according to the voltage value detected.
V=-Ib(t) Z (formula two)
So-called beam transformer is to go out current signal using the second level winding coupled on magnetic core, can be obtained by analyzing this signal
Obtain the electric current of original charged particle beam.It includes that (AC Current Transformer, is abbreviated as alternating current transformer
ACCT), fast current transformer (Fast Current Transformer, be abbreviated as FCT), resonant mode current transformer
(Tuned Current Transformer, be abbreviated as TCT), integration current transformer (Integrated Current
Transformer is abbreviated as ICT) and DC current transformer (DC Current Transformer, be abbreviated as DCCT).By
It is more in type, it is not listed one by one below with beam transformer, only is used to illustrate with DCCT.DCCT is modulated using nonlinear magnetism
Component detects the second harmonic of DC signal modulation to pumping signal to be measured.
In the present embodiment, the second current detection means 200 is galvanometer (galvanometer), during one end is electrically connected to
Sub- generating unit T, other end ground connection, to form a measure loop, to learn in charged particle beam P incident neutron generating unit T
During electric current on neutron generating unit T.Galvanometer is the principle deflected in magnetic field by torque according to current-carrying coil
It is manufactured.Ordinary electric meter coil is placed on bearing, is maintained to balance with spring balance spring, is indicated to deflect with pointer.By
There is friction in bearing, tested electric current cannot be too weak.Galvanometer replaces bearing suspension in magnetic field using superfine metal suspension, by
It is carefully grown in suspension, revolts torque very little, so there is very weak electric current by coil to be just enough that it is made to generate significant deflection.Cause
And galvanometer is sensitively more than general ammeter, can measure micro-current (10-7-10-10) or micro voltage (10 A-3-10- 6), such as photoelectric current, physiology electric current, thermoelectromotive force V.First record nerve action potential is exactly realized with this quasi-instrument.
Certainly, ground known to those skilled in the art, the second current detection means 200 can be suitable for be arbitrary in
Sub- generating unit is used to detect the intensity of the charged particle beam through acting on neutron generating unit and the detection device of changing condition, such as electricity
Flow table and voltage meter etc..
In the present embodiment, temperature-detecting device 300 is thermocouple (thermocouple), the conductor of two kinds of different components
(referred to as thermocouple silk material or thermode) both ends are bonded into circuit, when the temperature difference at junction, will generate in the loop
Electromotive force, this phenomenon is known as pyroelectric effect, and this electromotive force is known as thermoelectrical potential.Thermocouple is exactly to be carried out using this principle
Temperature measurement, wherein the one end for being directly used as measuring medium temperature is called working end (also referred to as measurement end), and the other end is called
Cold end (also referred to as compensating end)；Cold end is connect with display instrument or matching instrument, and display instrument would indicate that caused by thermocouple
Thermoelectrical potential.
Certainly, the known ground of those skilled in the art, temperature-detecting device 300 can be filled suitable for setting cooling to be arbitrary
It is used to detect cooling device temperature in learn that cooling device and neutron generating unit generate in setting or at neighbouring cooling device
The detection device of beamlet situation, such as resistance thermometer vary with temperature temperature made by the material of characteristic using known resistance
Sensor is spent, temperature is measured according to the rule that conductor resistance changes with temperature.
The common neutron beam monitoring device that real-time detection can be achieved has ionisation chamber and first two difference detection of flash detection former
Reason.Ionization cell structure is wherein used to have He-3 proportional counter, BF for substrate3Proportional counter, division Ionization chamber, boron ionization
Room, and flash detection head can then be divided into organic and inorganic material, for detection thermal neutron purposes, flash detection head adds more
The high thermal neutron capture cross section element such as Li or B.In brief, the neutron energy of such detection device detection is mostly thermal neutron, is all
It leans on element and reacts released heavy burden charged particle and nuclear fission fragment with neutron generation capture or nuclear fission, in ionisation chamber or sudden strain of a muscle
A large amount of ionization are generated in bright detecting head to (ion pair), it, can will by circuit conversion appropriate after these charges are collected
Current signal switchs to voltage pulse signal.Through analysis voltage pulse size, then can tell easily neutron signal and
γ signal.In high-intensitive neutron field, such as BNCT, then it can suitably reduce the gas pressure of ionisation chamber, material can be split or boron painting
The concentration of high neutron capture cross section element, can be effectively reduced it to the sensitive of neutron in the concentration or flash detection head of cloth
The case where spending, signal avoided to be saturated.
As it is further preferred that the first neutron beam monitoring device 400 be division Ionization chamber (fission chamber), when
When neutron beam is by division Ionization chamber, free make occurs with division Ionization chamber internal gas molecule or the wall portion for dividing Ionization chamber
With generation electronics and positively charged example, this electronics and positive charge ion are known as above-mentioned ion pair.Due to dividing Ionization chamber
Inside there is extra electric field high pressure, therefore electronics is mobile towards central anode silk, the cathode wall of positive charge ion towards surrounding is mobile, thus produces
Raw detectable electronic pulse signal.Energy needed for making gas molecule generate an ion pair be known as it is average free can, the value according to
Gaseous species and it is different, as air it is average it is free can be about 34eV.If there is the neutron beam of 340keV, air can be made to generate about 10k
A ion pair.
Certainly, the known ground of those skilled in the art, the first neutron beam monitoring device 400 can be suitable for being embedded in be arbitrary
The detection device of the intracorporal Strength Changes and spatial distribution for being used to detect the intracorporal neutron beam of beam-shaping of beam-shaping, such as
He-3 proportional counter, BF3Proportional counter, boron chamber and flash detection head etc..
As it is further preferred that the second neutron beam monitoring device 500 is flash detection head (scintillator
Detector), Cucumber can release visible light after absorbing energy, and such substance is known as scitillating material.It is using free
Radiation is used to make after being collected the electron excitation in crystal or molecule to sharp state, and the fluorescence released when electronics returns to ground state
Neutron beam monitoring.The visible light emitted after flash detection head and neutron beam effect, using photomultiplier tube it will be seen that light turns
Electronics is turned to, then amplification of doubling, usual electron multiplication magnifying power is up to 107 to 108.In the electron number and incidence of anode output
Beamlet energy is directly proportional, therefore flash detection head is capable of measuring the energy of neutron beam.
Certainly, the known ground of those skilled in the art, the second neutron beam monitoring device 500 can be suitable for being placed in penetrating to be arbitrary
In beam outlet or the Strength Changes of the neutron beam for being used to detect beam exit in neighbouring beam exit and spatial distribution
Detection device, such as He-3 proportional counter, BF3Proportional counter, boron chamber and division Ionization chamber etc..
As it is further preferred that displacement detector 600 is infrared detector, infrared detector is by detecting human body
The infrared ray of transmitting works.Detector is collected extraneous infra-red radiation and then is gathered on infrared sensor.It is infrared
Sensor generallys use pyroelectricity element, and this element will discharge electricity when having received infrared radiation temperature and issuing variation outward
Lotus generates alarm after detection processing.This detector is to detect human body radiation as target.So radio-sensitive element is to wave
A length of 10 μm or so of infra-red radiation must be very sensitive.
Certainly, the known ground of those skilled in the art, displacement detector 600 can be suitable for being used to detecting wait shine to be arbitrary
The detection device of body change in displacement, such as displacement sensor.So-called displacement sensor is according to the position according to the relatively a certain object of reference of body
Variation is moved to determine to whether move according to body.Also knownly, displacement detector can not only be used to examine those skilled in the art
The variation that can also be used to the displacements such as the fixed supporting element and/or instrument table to according to body of detection to the change in displacement according to body is surveyed, from
And it is learnt indirectly to the change in displacement according to body.
The known ground of those skilled in the art, the first current detection means, the second current detection means, temperature-detecting device,
The number and detecting element of first neutron beam monitoring device, the second neutron beam monitoring device and displacement detector are not limited to
This.
According to the mutual functional relation of the testing result of detection and/or monitoring device, can apparently enumerate
The fault diagnosis situation that the corresponding testing result of several bases is made is set forth below out in out of order component.
When detect the first current detection means, the second current detection means, temperature-detecting device, the first neutron beam monitoring
The detection of any one of device and the second neutron beam monitoring device or monitoring device are abnormal and other detections or monitoring dress
When setting normal, then detection or the monitoring device faults itself of the exception are inferred；When detecting that displacement detector is abnormal
And in other detections or the normal situation of monitoring device, then infer that position shifting changes or displacement detector is former wait shine
Barrier.
Neutron capture treatment system further comprises for by the accelerator of charged particle beam acceleration, when detecting the first electricity
Flow detection device, the second current detection means, temperature-detecting device, the first neutron beam monitoring device and the second neutron beam monitoring dress
It sets when being abnormal, then infers accelerator failure.
When detecting the second current detection means, temperature-detecting device, the first neutron beam monitoring device and the second neutron beam
Monitoring device be abnormal and when the first current detection means and normal displacement detector, then infer expand device therefore
Barrier.
When detecting that temperature-detecting device, the first neutron beam monitoring device and the second neutron beam monitoring device be abnormal
And when the first current detection means, the second current detection means and normal displacement detector, then infer neutron generating unit and/
Or cooling device failure.
When detecting that the first neutron beam monitoring device and the second neutron beam monitoring device are abnormal and the first electric current is examined
When surveying device, the second current detection means, temperature-detecting device and normal displacement detector, then the event of beam-shaping body is inferred
Barrier.
First neutron beam monitoring device includes the first neutron beam monitoring structure for being located at opposite sides in beam-shaping body
Part and the second neutron beam monitor component, and the second neutron beam monitoring device includes being located at the third of beam exit opposite sides
Neutron beam monitors component and the 4th neutron beam and monitors component, when detecting the first neutron beam monitoring component and the monitoring of the second neutron beam
Any in any one monitoring result exception and/or third neutron beam monitoring component and the 4th neutron beam monitoring component in component
A monitoring component is abnormal, then infers that the uniformity of abnormal neutron beam detection means faults itself or neutron beam is abnormal.
Certainly, the known ground of those skilled in the art, the above-described fault diagnosis situation made according to testing result is only
The several frequently seen situation enumerated, there are many kinds of permutation and combination, still can go to judge in which by above mode
There are which failures for son capture treatment system or detection device itself.Though here, not enumerating, according to such essence
The change that mind is made still falls within summary of the invention of the invention.
Beam diagnostic system includes the control device with control unit, and control unit is according to the testing result of beam diagnostic system
The signal of human perception is issued to confirm the next step operation of neutron capture treatment system.The signal of this human perception can be
The signal that the mankind such as the sense of hearing, vision, tactile or smell Functional tissue can perceive such as issues alarm device, the alarm lamp, vibration of the sound
One of multi-signals or the diversified forms such as move, give out a pungent smell.Preferably as one kind, control device further includes showing
Show portion, the fault diagnosis situation that display unit is used to will test the testing result of device and/or make according to testing result is shown in
It shows in equipment, display equipment can be the common display equipment such as TV or liquid crystal display.By the feedback of control device,
Operator can easily conclude trouble unit, so that shoots the arrow at the target examines neutron capture treatment system and/or beam
Disconnected system carries out upkeep operation.
Detailed description of the invention
Fig. 1 is boron neutron capture reaction schematic diagram.
Fig. 2 is10B(n,α)7Li neutron capture nuclear equation formula.
Fig. 3 is the floor map of the beam diagnostic system for neutron capture treatment system in the embodiment of the present invention.
Fig. 4 is the logical box that the beam diagnostic system for neutron capture treatment system in the embodiment of the present invention is run
Figure.
Fig. 5 is the floor map of another embodiment of the first neutron beam monitoring device in beam diagnostic system.
Specific embodiment
Neutron capture treatment as a kind of effective treating cancer means in recent years using gradually increasing, wherein with boron
Neutron capture treatment is most commonly seen, and the neutron of supply boron neutron capture treatment can be supplied by nuclear reactor or accelerator.This hair
By taking the treatment of accelerator boron neutron capture as an example, the basic module of accelerator boron neutron capture treatment generally includes to use bright embodiment
In the accelerator, target and hot removal system and beam-shaping body that are accelerated to charged particle (such as proton, deuteron), wherein
Accelerate charged particle and metal targets effect to generate neutron, is charged according to required neutron yield rate and energy, available acceleration
The characteristics such as the materialization of particle energy and size of current, metal targets select suitable nuclear reaction, the nuclear reaction being often discussed
Have7Li(p,n)7Be and9Be(p,n)9B, both reactions are all the endothermic reaction.The energy threshold of two kinds of nuclear reactions is respectively
1.881MeV and 2.055MeV, it is theoretical due to the epithermal neutron that the ideal neutron source of boron neutron capture treatment is keV energy grade
If the upper proton bombardment lithium metal target for being only slightly taller than threshold values using energy can produce the neutron of opposite low energy, be not necessary to too many
Slow processing can be used for clinic, however the proton-effect of two kinds of targets of lithium metal (Li) and beryllium metal (Be) and threshold values energy is cut
Face is not high, to generate sufficiently large neutron flux, the proton of higher-energy is usually selected to cause nuclear reaction.
Ideal target should have high neutron yield rate, the neutron energy of generation is distributed (will be under close to epithermal neutron energy area
Text detailed description), without wear by force too much radiation generate, the characteristics such as cheap easily operated and high temperature resistant of safety, but actually and can not
It finds and meets required nuclear reaction, using target made of lithium metal in the embodiment of the present invention.But art technology
Known to personnel, the material of target can also be made of other metal materials other than the above-mentioned metal material talked about.
Requirement for hot removal system is then different according to the nuclear reaction of selection, such as7Li(p,n)7Be is because of metal targets (lithium
Metal) fusing point and thermal conductivity coefficient it is poor, requirement to hot removal system just compared with9Be(p,n)9B high.It is adopted in the embodiment of the present invention
With7Li(p,n)7The nuclear reaction of Be.
No matter boron neutron capture treatment nuclear reaction of the neutron source from nuclear reactor or accelerator charged particle and target,
What is generated is all mixed radiation field, i.e., beam contains neutron, photon of the low energy to high energy；The boron neutron of deep tumor is caught
Treatment is obtained, other than epithermal neutron, remaining radiation content is more, causes the ratio of the non-selective dosage deposition of normal tissue
It is bigger, therefore these radiation that will cause unnecessary dosage should reduce as far as possible.In addition to air beam quality factor, in knowing more about
Son in human body caused by dosage be distributed, carry out Rapid Dose Calculation using human body head tissue prosthese in the embodiment of the present invention, and
With prosthese beam quality factor as the design reference of neutron beam, will be described in more detail below.
International Atomic Energy Agency (IAEA) is directed to the neutron source of clinical boron neutron capture treatment, penetrates given five air
Beam quality factor suggestion, this five suggestions can be used for the superiority and inferiority of the different neutron sources of comparison, and be provided with as select neutron generate way
Reference frame when diameter, design beam-shaping body.This five suggestion difference are as follows:
Epithermal neutron beam flux Epithermal neutron flux > 1x 109n/cm2s
Fast neutron pollutes Fast neutron contamination < 2x 10-13Gy-cm2/n
Photon contamination Photon contamination < 2x 10-13Gy-cm2/n
Ratio < 0.05 thermal and epithermal neutron flux ratio thermal to epithermal neutron flux
Middle electron current and ratio > 0.7 flux ratio epithermal neutron current to flux
Note: subzone is hankered less than 0.5eV, fast-neutron range is greater than between 0.5eV to 40keV in epithermal neutron energy area
40keV。
1, epithermal neutron beam flux:
Boracic drug concentration has codetermined the clinical treatment time in neutron beam flux and tumour.If tumour boracic drug
The enough height of concentration, the requirement for neutron beam flux can reduce；Conversely, needing high pass if boracic drug concentration is low in tumour
Epithermal neutron is measured to give tumour enough dosage.Requirement of the IAEA for epithermal neutron beam flux is per second every square centimeter
Epithermal neutron number be greater than 109, the neutron beam under this flux can substantially control treatment for current boracic drug
Time, short treatment time, can also relatively effective use boracic medicine other than advantageous to patient's positioning and comfort level in one hour
Object limited residence time in tumour.
2, fast neutron pollutes:
Since fast neutron will cause unnecessary normal tissue dose, regard as pollution, this dosage size and neutron
Energy is positively correlated, therefore should reduce the content of fast neutron to the greatest extent in neutron beam design.Fast neutron pollution definition is unit
The adjoint fast neutron dosage of epithermal neutron flux, IAEA are less than 2x 10 to the suggestion that fast neutron pollutes-13Gy-cm2/n。
3, photon contamination (gamma-ray contamination):
Gamma-rays, which belongs to, wears radiation by force, can non-selectively cause the organized dosage deposition of institute on course of the beam, therefore
Reduce gamma-rays content be also neutron beam design exclusive requirement, gamma-ray contamination define for unit epithermal neutron flux it is adjoint
Gamma-rays dosage, IAEA are less than 2x 10 to the suggestion of gamma-ray contamination-13Gy-cm2/n。
4, thermal and epithermal neutron flux ratio:
Since thermal neutron decay speed is fast, penetration capacity is poor, into human body after most of energy be deposited on skin histology, remove
It is swollen for deep layers such as brain tumors outside the neutron source that the Several Epidermal Tumors such as melanocytoma need to use thermal neutron to treat as boron neutron capture
Tumor should reduce thermal neutron content.IAEA is less than 0.05 to thermal and epithermal neutron flux ratio suggestion.
5, middle electron current and flux ratio:
Middle electron current and flux ratio represent the directionality of beam, and tropism is good before the bigger expression neutron beam of ratio, high
The neutron beam of preceding tropism can reduce because neutron diverging caused by normal surrounding tissue dosage, in addition also improve can treat depth and
Put pose gesture elasticity.IAEA centering electron current and flux ratio suggestion are greater than 0.7.
The dosage in tissue is obtained using prosthese to be distributed, and according to the dose versus depth curve of normal tissue and tumour, pushes away false
Body beam quality factor.Following three parameter can be used for carrying out the comparison of different neutron beam treatment benefits.
1, effective therapeutic depth:
Depth of the tumor dose equal to normal tissue maximum dose, the position after this depth, what tumour cell obtained
Dosage is less than normal tissue maximum dose, that is, loses the advantage of boron neutron capture.What this parameter represented neutron beam penetrates energy
Power, effective therapeutic depth is bigger to indicate that medicable tumor depth is deeper, unit cm.
2, effective therapeutic depth dosage rate:
That is the tumor dose rate of effective therapeutic depth is also equal to the maximum dose rate of normal tissue.Because normal tissue receives
Accumulated dose is the factor for influencing to give tumour accumulated dose size, therefore parameter influences the length for the treatment of time, and effectively treatment is deep
Irradiation time needed for tumour doses are given in the bigger expression of degree dosage rate is shorter, unit cGy/mA-min.
3, dose therapeutically effective ratio:
From brain surface to effective therapeutic depth, tumour and the received mean dose ratio of normal tissue, referred to as effectively
Therapeutic dose ratio；The calculating of mean dose can be integrated to obtain by dose versus depth curve.Dose therapeutically effective ratio is bigger, represents
The treatment benefit of the neutron beam is better.
Compare foundation to there is beam-shaping body in design, in addition to five IAEA suggest air in beam quality because
Three plain and above-mentioned parameters also utilize in the embodiment of the present invention following for assessing the ginseng of neutron beam dosage performance superiority and inferiority
Number:
1, irradiation time≤30min (proton current that accelerator uses is 10mA)
2,30.0RBE-Gy can treat depth >=7cm
3, tumour maximum dose >=60.0RBE-Gy
4, normal cerebral tissue's maximum dose≤12.5RBE-Gy
5, skin maximum dose≤11.0RBE-Gy
Note: RBE (Relative Biological Effectiveness) is relative biological effect, due to photon, neutron
The biological effect that will cause is different, thus dosage item as above be multiplied by respectively the relative biological effect of different tissues in the hope of etc.
Imitate dosage.
Fig. 3 and Fig. 4 are referred to, one aspect of the present invention is to improve the neutron beam irradiation agent of neutron capture treatment system
The accuracy of amount and a kind of beam diagnostic system that can be used in neutron capture treatment system is provided to carry out fault diagnosis, one
A kind of beam diagnostic system for neutron capture treatment system is provided in a technical solution.
Wherein, neutron capture treatment system includes accelerator 10, expand device 20, the band for passing through charged particle beam P
Charged particle beam P, with charged particle beam P nuclear reaction is occurred for charged particle beam entrance to generate the neutron generating unit of neutron beam N
T, for adjusting the beam-shaping body 30 of the neutron beam flux and quality that generate through neutron generating unit T, being adjacent to beam-shaping
The beam outlet 40 of body 30, by the beam exposure through being come out at beam outlet 40 to according to body 50 and for cooling medium to be placed in
The cooling device 60 of neutron generating unit T is cooled down at neutron generating unit T.Wherein, accelerator 10 is used to add to charged particle beam P
Speed can be suited to speed up the accelerator of type neutron capture treatment system for cyclotron or linear accelerator etc.；This
In charged particle beam P be preferably proton beam；Expand device 20 is arranged between accelerator 10 and neutron generating unit T；Band electrochondria
Beamlet entrance is close to neutron generating unit T and is contained in beam-shaping body 30, as shown in Figure 3 in neutron generating unit T and to expand
Three arrows between device are as charged particle beam entrance；Neutron generating unit T is contained in beam-shaping body 30, here in
Sub- generating unit T is preferably lithium metal；Beam-shaping body 30 includes reflector 31, is surrounded by reflector 31 and is adjacent to neutron generation
The slow body 32 of portion T, the thermal neutron absorber 33 adjacent with slow body 32, the radiation shield being arranged in beam-shaping body 30
Nuclear reaction occurs for 34, neutron generating unit T to generate neutron beam N, neutron with the charged particle beam P from charged particle beam entrance incidence
Beam limits a main shaft, and for slow body 32 by from the neutron degradation that neutron generating unit T is generated to epithermal neutron energy area, reflector 31 will
The neutron for deviateing main shaft leads back to main shaft to improve epithermal neutron intensity of beam, and thermal neutron absorber 33 is for absorbing thermal neutron to keep away
Multi-dose was caused when exempting from treatment with shallow-layer normal tissue, radiation shield 34 is used to shield the neutron leaked and photon is non-to reduce
The normal tissue dose of irradiated region；Beam outlet 40 also referred to as neutron beam convergent part or collimator, reduce neutron beam
Width is to assemble neutron beam；The neutron beam projected through beam outlet 40 is irradiated to the target site according to body 50.
Wherein, beam diagnostic system includes charged particle beam diagnostic device and neutron beam diagnostic device, beam diagnostic system
For diagnose simultaneously neutron capture treatment system and/or beam diagnostic system whether failure.Beam diagnostic system passes through while examining
Charged particle beam and neutron beam are surveyed, to improve the accuracy of neutron beam exposure dose.In addition, beam diagnostic system is by a series of
Testing result judging that it is abnormal which device in neutron capture treatment system and/or component generate, or judgement is penetrated
Whether the detection device itself in beam diagnostic system is abnormal.It can accomplish to shoot the arrow at the target in this way, improve neutron beam exposure dose
Accuracy, and greatly reduce maintenance time and cost.
Charged particle beam diagnostic device further comprises for detecting the band electrochondria located before entering charged particle beam entrance
The intensity of beamlet P and the first current detection means 100 of stability and the band electrochondria acted on for detecting warp with neutron generating unit T
The intensity of beamlet P and the second current detection means 200 of changing condition；Beam diagnostic system further comprises for detecting cooling
60 temperature of device is to learn that cooling device 60 and neutron generating unit T generate the temperature-detecting device 300 of neutron beam N situation；In
Beamlet diagnostic device further comprises Strength Changes for detecting the neutron beam N in beam-shaping body 30 and spatial distribution, buries
The first neutron beam monitoring device 400 in beam-shaping body 30 and for detecting the strong of the neutron beam N at beam outlet 40
Degree variation and spatial distribution, be embedded in beam outlet 40 at the second neutron beam monitoring device 500；Beam diagnostic system is further
Including for diagnosing to be displaced the displacement detector 600 whether moved according to body 50.Preferably as one kind, the first neutron beam prison
Surveying the setting of device 400, there are two neutron beams to monitor component, i.e. the first neutron beam monitors component 401 and the second neutron beam monitors component
402；There are two neutron beams to monitor component, i.e. third neutron beam monitoring component 501 and for the setting of second neutron beam monitoring device 500
Four neutron beams monitor component 502；There are two displacement detecting components, i.e. the first displacement detecting component for the setting of displacement detector 600
601 and second displacement detection means 602.
Though the first neutron beam monitoring device 400, the second neutron beam monitoring device 500 and displacement detecting dress in the present embodiment
It sets 600 to be respectively provided with there are two respective monitoring/detection means, but the known ground of those skilled in the art, these monitor/detect structure
The number of part, which can according to need, to be set, and such as may be 4,6 or 8.As long as it is embedded that neutron beam monitors component
During (or neighbouring beam exports) can be used to detect in beam-shaping body (or adjacent to beam-shaping body) and/or in beam outlet
The Strength Changes and spatial distribution of beamlet, then this neutron beam monitoring component can be selected；As long as displacement detecting component is arranged
To be used to detect wait shine body change in displacement, then this displacement detecting component can select according to (or neighbouring wait shine body) in vivo
With.In addition, there is no stringent limitations for these monitorings/detection means placement position, as long as the position placed can play respectively
Self-corresponding detection function.
Such setting, so that from the source of accelerator until being both provided with miscellaneous detection to the terminal according to body
Device, judged by these detection devices neutron capture treatment system each critical component or detection device itself whether
There are exceptions.Preferably as one kind, from the source of accelerator until to which detection device is arranged as the terminal according to body: adding
It is provided with detection device at vacuum tube at fast device source, is provided with detection device at neutron generating unit, close to neutron generating unit
And for being provided with detection dress in beam-shaping body to detection device is provided at the cooling cooling device of neutron generating unit
It sets, beam exit is provided with detection device, is provided with detection device at body wait shine.
In the present embodiment, the first current detection means 100 is Faraday cup (Faraday cup electrometer),
Being that one kind is metal is designed to cup-shaped, for measuring a kind of vacuum detector of charged particle beam incident intensity and stability,
The electric current measured can be used to determine the quantity of charged particle beam.After charged particle beam enters Faraday cup, electricity can be generated
Stream.For a continuous singularly charged charged particle beam: being calculated using formula one, wherein N is number of charged particles
It is that electric current (unit is ampere), the e measured is elementary charge (about 1.60 × 10 that amount, t, which are time (unit is the second), I,-19Coulomb).
We can be evaluated whether, if measuring electric current is 10-9A (1nA), i.e., there are about 6,000,000,000 charged particles is collected by Faraday cup.
Certainly, the known ground of those skilled in the art, the first current detection means 100 can be suitable for be arbitrary in accelerator
It is used to measure the detection device of charged particle beam incident intensity and stability at vacuum tube, such as wall current detector (Wall
Current Monitor) and beam transformer (Beam Current Transformer).
Sample resistance is connected across ceramic distance piece both ends by so-called wall current detector, and line image current flows through sampling electricity
It can be obtained voltage sampling signal when resistance, calculated using formula two, wherein V is the voltage value detected, IbFor charged particle
Beam current, Z can be equivalent to resistance under specific frequency, and wall current detector equivalent circuit is Parallel RLC Circuit, such as formula
Three.Therefore electric current of the charged particle beam in certain time period t can be extrapolated according to the voltage value detected.
V=-Ib(t) Z (formula two)
So-called beam transformer is to go out current signal using the second level winding coupled on magnetic core, can be obtained by analyzing this signal
Obtain the electric current of original charged particle beam.It includes that (AC Current Transformer, is abbreviated as alternating current transformer
ACCT), fast current transformer (Fast Current Transformer, be abbreviated as FCT), resonant mode current transformer
(Tuned Current Transformer, be abbreviated as TCT), integration current transformer (Integrated Current
Transformer is abbreviated as ICT) and DC current transformer (DC Current Transformer, be abbreviated as DCCT).By
It is more in type, it is not listed one by one below with beam transformer, only is used to illustrate with DCCT.DCCT is modulated using nonlinear magnetism
Component detects the second harmonic of DC signal modulation to pumping signal to be measured.
In the present embodiment, the second current detection means 200 is galvanometer (galvanometer), during one end is electrically connected to
Sub- generating unit T, other end ground connection, to form a measure loop, to learn in charged particle beam P incident neutron generating unit T
During electric current on neutron generating unit T.Galvanometer is the principle deflected in magnetic field by torque according to current-carrying coil
It is manufactured.Ordinary electric meter coil is placed on bearing, is maintained to balance with spring balance spring, is indicated to deflect with pointer.By
There is friction in bearing, tested electric current cannot be too weak.Galvanometer replaces bearing suspension in magnetic field using superfine metal suspension, by
It is carefully grown in suspension, revolts torque very little, so there is very weak electric current by coil to be just enough that it is made to generate significant deflection.Cause
And galvanometer is sensitively more than general ammeter, can measure micro-current (10-7-10-10) or micro voltage (10 A-3-10- 6), such as photoelectric current, physiology electric current, thermoelectromotive force V.First record nerve action potential is exactly realized with this quasi-instrument.
Certainly, ground known to those skilled in the art, the second current detection means 200 can be suitable for be arbitrary in
Sub- generating unit is used to detect the intensity of the charged particle beam through acting on neutron generating unit and the detection device of changing condition, such as electricity
Flow table and voltage meter etc..
In the present embodiment, temperature-detecting device 300 is thermocouple (thermocouple), the conductor of two kinds of different components
(referred to as thermocouple silk material or thermode) both ends are bonded into circuit, when the temperature difference at junction, will generate in the loop
Electromotive force, this phenomenon is known as pyroelectric effect, and this electromotive force is known as thermoelectrical potential.Thermocouple is exactly to be carried out using this principle
Temperature measurement, wherein the one end for being directly used as measuring medium temperature is called working end (also referred to as measurement end), and the other end is called
Cold end (also referred to as compensating end)；Cold end is connect with display instrument or matching instrument, and display instrument would indicate that caused by thermocouple
Thermoelectrical potential.
Certainly, the known ground of those skilled in the art, temperature-detecting device 300 can be filled suitable for setting cooling to be arbitrary
It is used to detect cooling device temperature in learn that cooling device and neutron generating unit generate in setting or at neighbouring cooling device
The detection device of beamlet situation, such as resistance thermometer vary with temperature temperature made by the material of characteristic using known resistance
Sensor is spent, temperature is measured according to the rule that conductor resistance changes with temperature.
The common neutron beam monitoring device that real-time detection can be achieved has ionisation chamber and first two difference detection of flash detection former
Reason.Ionization cell structure is wherein used to have He-3 proportional counter, BF for substrate3Proportional counter, division Ionization chamber, boron ionization
Room, and flash detection head can then be divided into organic and inorganic material, for detection thermal neutron purposes, flash detection head adds more
The high thermal neutron capture cross section element such as Li or B.In brief, the neutron energy of such detection device detection is mostly thermal neutron, is all
It leans on element and reacts released heavy burden charged particle and nuclear fission fragment with neutron generation capture or nuclear fission, in ionisation chamber or sudden strain of a muscle
A large amount of ionization are generated in bright detecting head to (ion pair), it, can will by circuit conversion appropriate after these charges are collected
Current signal switchs to voltage pulse signal.Through analysis voltage pulse size, then can tell easily neutron signal and
γ signal.In high-intensitive neutron field, such as BNCT, then it can suitably reduce the gas pressure of ionisation chamber, material can be split or boron painting
The concentration of high neutron capture cross section element, can be effectively reduced it to the sensitive of neutron in the concentration or flash detection head of cloth
The case where spending, signal avoided to be saturated.
As it is further preferred that the first neutron beam monitoring device 400 be division Ionization chamber (fission chamber), when
When neutron beam is by division Ionization chamber, free make occurs with division Ionization chamber internal gas molecule or the wall portion for dividing Ionization chamber
With generation electronics and positively charged example, this electronics and positive charge ion are known as above-mentioned ion pair.Due to dividing Ionization chamber
Inside there is extra electric field high pressure, therefore electronics is mobile towards central anode silk, the cathode wall of positive charge ion towards surrounding is mobile, thus produces
Raw detectable electronic pulse signal.Energy needed for making gas molecule generate an ion pair be known as it is average free can, the value according to
Gaseous species and it is different, as air it is average it is free can be about 34eV.If there is the neutron beam of 340keV, air can be made to generate about 10k
A ion pair.
Certainly, the known ground of those skilled in the art, the first neutron beam monitoring device 400 can be suitable for being embedded in be arbitrary
The detection device of the intracorporal Strength Changes and spatial distribution for being used to detect the intracorporal neutron beam of beam-shaping of beam-shaping, such as
He-3 proportional counter, BF3Proportional counter, boron chamber and flash detection head etc..
As it is further preferred that the second neutron beam monitoring device 500 is flash detection head (scintillator
Detector), Cucumber can release visible light after absorbing energy, and such substance is known as scitillating material.It is using free
Radiation is used to make after being collected the electron excitation in crystal or molecule to sharp state, and the fluorescence released when electronics returns to ground state
Neutron beam monitoring.The visible light emitted after flash detection head and neutron beam effect, using photomultiplier tube it will be seen that light turns
Electronics is turned to, then amplification of doubling, usual electron multiplication magnifying power is up to 107 to 108.In the electron number and incidence of anode output
Beamlet energy is directly proportional, therefore flash detection head is capable of measuring the energy of neutron beam.
Certainly, the known ground of those skilled in the art, the second neutron beam monitoring device 500 can be suitable for being placed in penetrating to be arbitrary
In beam outlet or the Strength Changes of the neutron beam for being used to detect beam exit in neighbouring beam exit and spatial distribution
Detection device, such as He-3 proportional counter, BF3Proportional counter, boron chamber and division Ionization chamber etc..
As it is further preferred that displacement detector 600 is infrared detector, infrared detector is by detecting human body
The infrared ray of transmitting works.Detector is collected extraneous infra-red radiation and then is gathered on infrared sensor.It is infrared
Sensor generallys use pyroelectricity element, and this element will discharge electricity when having received infrared radiation temperature and issuing variation outward
Lotus generates alarm after detection processing.This detector is to detect human body radiation as target.So radio-sensitive element is to wave
A length of 10 μm or so of infra-red radiation must be very sensitive.
Certainly, the known ground of those skilled in the art, displacement detector 600 can be suitable for being used to detecting wait shine to be arbitrary
The detection device of body change in displacement, such as displacement sensor.So-called displacement sensor is according to the position according to the relatively a certain object of reference of body
Variation is moved to determine to whether move according to body.Also knownly, displacement detector can not only be used to examine those skilled in the art
The variation that can also be used to the displacements such as the fixed supporting element and/or instrument table to according to body of detection to the change in displacement according to body is surveyed, from
And it is learnt indirectly to the change in displacement according to body.
The known ground of those skilled in the art, the first current detection means, the second current detection means, temperature-detecting device,
The number and detecting element of first neutron beam monitoring device, the second neutron beam monitoring device and displacement detector do not limit,
Number and detecting element in the present embodiment are intended only as a kind of citing.
According to the mutual functional relation of the testing result of detection and/or monitoring device, can apparently enumerate
The fault diagnosis situation that the corresponding testing result of several bases is made is set forth below out in out of order component.
When detecting the first current detection means 100, the second current detection means 200, temperature-detecting device 300, first
The detection of any one of neutron beam monitoring device 400 and the second neutron beam monitoring device 500 or monitoring device be abnormal and
When other detections or normal monitoring device, then detection or the monitoring device faults itself of the exception are inferred；It is displaced when detecting
Detection device 600 is abnormal in other detections or the normal situation of monitoring device, then is inferred to occur according to the displacement of body 50
Variation or 600 failure of displacement detector.
When detecting the first current detection means 100, the second current detection means 200, temperature-detecting device 300, first
When neutron beam monitoring device 400 and the second neutron beam monitoring device 500 are abnormal, then 10 failure of accelerator is inferred.
When detecting the second current detection means 200, temperature-detecting device 300, the first neutron beam monitoring device 400 and
Two neutron beam monitoring devices 500 are abnormal and when the first current detection means 100 and normal displacement detectors 600,
Then infer 20 failure of expand device.
When detecting temperature-detecting device 300, the first neutron beam monitoring device 400 and the second neutron beam monitoring device 500
Be abnormal and when the first current detection means 100, the second current detection means 200 and normal displacement detector 600,
Then infer 60 failure of neutron generating unit T and/or cooling device.
When detect that the first neutron beam monitoring device 400 and the second neutron beam monitoring device 500 are abnormal and first
When current detection means 100, the second current detection means 200, temperature-detecting device 300 and normal displacement detector 600,
Then infer 30 failure of beam-shaping body.
It is tied when detecting that any of the first neutron beam monitoring component 401 and the second neutron beam monitoring component 402 monitor
Any of fruit exception and/or third neutron beam monitoring component 501 and the 4th neutron beam monitoring component 502 monitoring component are different
Often, then infer that the uniformity of abnormal neutron beam detection means faults itself or neutron beam is abnormal.
Certainly, the known ground of those skilled in the art, the above-described fault diagnosis situation made according to testing result is only
The several frequently seen situation enumerated, there are many kinds of permutation and combination, still can go to judge in which by above mode
There are which failures for son capture treatment system or detection device itself.Though here, not enumerating, according to such essence
The change that mind is made still falls within summary of the invention of the invention.
Beam diagnostic system includes the control device 700 with control unit 710, and control unit 710 is according to beam diagnostic system
Testing result issue the signal of human perception to confirm the next step operation of neutron capture treatment system.This human perception
Signal can be the signal that the mankind such as the sense of hearing, vision, tactile or smell Functional tissue can perceive, and such as issue the alarm of the sound
Device one of the multi-signals such as alarm lamp, vibrates, gives out a pungent smell or diversified forms.Preferably as one kind, control
Device 700 further includes display unit 720, and display unit 720 is used to will test the testing result of device and/or makes according to testing result
Fault diagnosis situation be shown in display equipment, display equipment can set for the common display such as TV or liquid crystal display
It is standby.By the feedback of control device, operator can easily conclude trouble unit, so that shoots the arrow at the target catches neutron
It obtains treatment system and/or beam diagnostic system carries out upkeep operation.
With further reference to Fig. 5, it to be mark with number 400 ' that there is disclosed another embodiments of the first neutron beam monitoring device
Remember, device/component identical with Fig. 3 in diagram, still using identical number mark, and for the ease of display, is omitted
Cooling device and other detection/detection devices.
First neutron beam monitoring device 400 ' may include one or more neutron beam monitoring component, and it can set
It sets at neighbouring beam-shaping body 30 to detect the neutron beam overflowed through neutron generating unit T to detect in this in a straightforward manner
The Strength Changes and spatial distribution of beamlet, also can be set at neighbouring beam-shaping body 30 with detect through charged particle beam P with
The gamma-rays generated after neutron generating unit T effect can also detect indirectly according to the functional relation between gamma-rays and neutron beam
The Strength Changes and spatial distribution of neutron beam.Control device 700 ' includes control unit 710 ' and display unit 720 '.Display unit 720 '
For will test the testing result of device 400 ' and/or according to testing result the fault diagnosis situation made is shown in display equipment
On, display equipment can be the common display equipment such as TV or liquid crystal display.By the feedback of control device, operator
Trouble unit can be easily concluded, so that shoots the arrow at the target carries out next step operation to accelerator 10.
To sum up, no matter the first neutron beam monitoring device is arranged in beam-shaping body, still it is positioned adjacent to beam
At shaping body, as long as can be used to detect Strength Changes and the space of the intracorporal neutron beam of beam-shaping in place of set seated position
The detection device of distribution can then be selected.
The beam diagnostic system for neutron capture treatment system that the present invention discloses is not limited to above embodiments institute
Structure represented by the content and attached drawing stated.The material and shape and position of wherein component are done on the basis of the present invention
Apparently change, substitution or modification, all within the scope of protection of present invention.
Claims (11)
1. a kind of beam diagnostic system for neutron capture treatment system, it is characterised in that: the neutron capture treatment system
Including charged particle beam, for by the charged particle beam entrance of the charged particle beam, through occurring with the charged particle beam
Nuclear reaction is to generate the neutron generating unit of neutron beam, for cooling medium to be placed at the neutron generating unit described in cooling
The cooling device of neutron generating unit, the beam for adjusting the neutron beam flux and quality that generate through the neutron generating unit are whole
Body and the beam outlet for being adjacent to the beam-shaping body, wherein it is whole that the charged particle beam entrance is contained in the beam
In body, the neutron generating unit is contained in the beam-shaping body, and the beam diagnostic system includes that charged particle beam is examined
Disconnected device and for detecting the cooling device temperature to learn that the cooling device and neutron generating unit generate neutron pencil
The temperature-detecting device or neutron beam diagnostic device of condition and for detecting the cooling device temperature to learn the cooling dress
The temperature-detecting device that neutron beam situation is generated with neutron generating unit is set, the beam diagnostic system is used to while diagnosing neutron catch
Obtain treatment system and/or beam diagnostic system whether failure.
2. the beam diagnostic system according to claim 1 for neutron capture treatment system, it is characterised in that: described to penetrate
Beam diagnostic system includes charged particle beam diagnostic device, neutron beam diagnostic device and the temperature-detecting device.
3. the beam diagnostic system according to claim 1 for neutron capture treatment system, it is characterised in that: described to penetrate
Beam diagnostic system includes the intensity and changing condition for detecting the charged particle beam through acting on the neutron generating unit
The second current detection means, the Strength Changes for detecting the intracorporal neutron beam of the beam-shaping and spatial distribution, embedded
In the intracorporal first neutron beam monitoring device of the beam-shaping and the temperature-detecting device.
4. the beam diagnostic system according to claim 1 for neutron capture treatment system, it is characterised in that: described to penetrate
Beam diagnostic system includes the intensity and changing condition for detecting the charged particle beam through acting on the neutron generating unit
The second current detection means, neutron beam for detecting the beam exit Strength Changes and spatial distribution, be embedded in
The second neutron beam monitoring device in the beam exit and the temperature-detecting device.
5. the beam diagnostic system according to claim 1 for neutron capture treatment system, it is characterised in that: described to penetrate
Beam diagnostic system includes the intensity and changing condition for detecting the charged particle beam through acting on the neutron generating unit
The second current detection means, be positioned adjacent at beam-shaping body with detect the neutron beam overflowed through neutron generating unit to
Direct mode detects the Strength Changes of the neutron beam and the first neutron beam monitoring device of spatial distribution and temperature inspection
Survey device.
6. the beam diagnostic system according to claim 1 for neutron capture treatment system, it is characterised in that: described to penetrate
Beam diagnostic system includes the intensity and changing condition for detecting the charged particle beam through acting on the neutron generating unit
The second current detection means, generated after charged particle beam and the effect of neutron generating unit with detecting at neighbouring beam-shaping body
Gamma-rays and according to the function between gamma-rays and neutron beam detect indirectly neutron beam Strength Changes and spatial distribution first
Neutron beam monitoring device and the temperature-detecting device.
7. the beam diagnostic system according to claim 1 for neutron capture treatment system, it is characterised in that: described to penetrate
Beam diagnostic system includes for detecting into the intensity of the charged particle beam located before the charged particle beam entrance and steady
The first current detection means spent surely, the Strength Changes for detecting the intracorporal neutron beam of the beam-shaping and spatial distribution,
It is embedded in the intracorporal first neutron beam monitoring device of the beam-shaping and the temperature-detecting device.
8. the beam diagnostic system according to claim 1 for neutron capture treatment system, it is characterised in that: described to penetrate
Beam diagnostic system includes for detecting into the intensity of the charged particle beam located before the charged particle beam entrance and steady
Surely the first current detection means spent, the Strength Changes of the neutron beam for detecting the beam exit and spatial distribution are buried
Set on the second neutron beam monitoring device in the beam exit and the temperature-detecting device.
9. the beam diagnostic system according to claim 1 for neutron capture treatment system, it is characterised in that: described to penetrate
Beam diagnostic system includes for detecting into the intensity of the charged particle beam located before the charged particle beam entrance and steady
Surely the first current detection means for spending, be positioned adjacent at beam-shaping body with detect the neutron beam overflowed through neutron generating unit from
And the Strength Changes of the neutron beam and the first neutron beam monitoring device of spatial distribution and the temperature are detected in a straightforward manner
Spend detection device.
10. the beam diagnostic system according to claim 1 for neutron capture treatment system, it is characterised in that: described
Beam diagnostic system include for detect the intensity into the charged particle beam located before the charged particle beam entrance with
To detect after charged particle beam and the effect of neutron generating unit at first current detection means of stability, neighbouring beam-shaping body
The gamma-rays of generation and the Strength Changes and spatial distribution for detecting neutron beam indirectly according to the function between gamma-rays and neutron beam
The first neutron beam monitoring device and the temperature-detecting device.
11. the beam diagnostic system according to claim 1 to 10 for neutron capture treatment system, special
Sign is: the neutron capture treatment system further comprises the beam exposure come out through the beam exit wait shine
Body, the beam diagnostic system further comprise described to move the displacement detector whether moved according to position for diagnosing.
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| CN106552322A (en) | 2017-04-05 |
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| CN109011206B (en) | 2020-12-08 |
| CN109011207B (en) | 2020-10-16 |
| CN109011207A (en) | 2018-12-18 |
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