CN109420258B - Neutron capture therapy system - Google Patents
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- CN109420258B CN109420258B CN201710733144.1A CN201710733144A CN109420258B CN 109420258 B CN109420258 B CN 109420258B CN 201710733144 A CN201710733144 A CN 201710733144A CN 109420258 B CN109420258 B CN 109420258B
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- 238000002560 therapeutic procedure Methods 0.000 title claims description 22
- 239000000463 material Substances 0.000 claims abstract description 60
- 238000007493 shaping process Methods 0.000 claims abstract description 31
- 239000002245 particle Substances 0.000 claims abstract description 28
- 238000011282 treatment Methods 0.000 claims abstract description 20
- 238000001228 spectrum Methods 0.000 claims abstract description 16
- 229910001245 Sb alloy Inorganic materials 0.000 claims description 13
- 238000010521 absorption reaction Methods 0.000 claims description 13
- 239000002140 antimony alloy Substances 0.000 claims description 13
- 230000004913 activation Effects 0.000 claims description 6
- 229910000838 Al alloy Inorganic materials 0.000 claims description 5
- 239000000956 alloy Substances 0.000 abstract description 17
- 230000000694 effects Effects 0.000 abstract description 13
- 238000004519 manufacturing process Methods 0.000 abstract description 4
- 230000003760 hair shine Effects 0.000 abstract 2
- 238000005253 cladding Methods 0.000 abstract 1
- 239000011162 core material Substances 0.000 description 51
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 13
- 229910052796 boron Inorganic materials 0.000 description 13
- 210000004027 cell Anatomy 0.000 description 11
- 230000005855 radiation Effects 0.000 description 11
- 229910000978 Pb alloy Inorganic materials 0.000 description 6
- 229910052787 antimony Inorganic materials 0.000 description 6
- WATWJIUSRGPENY-UHFFFAOYSA-N antimony atom Chemical compound [Sb] WATWJIUSRGPENY-UHFFFAOYSA-N 0.000 description 6
- 210000004881 tumor cell Anatomy 0.000 description 6
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- 229910017052 cobalt Inorganic materials 0.000 description 1
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- 238000002661 proton therapy Methods 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
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- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05H—PLASMA TECHNIQUE; PRODUCTION OF ACCELERATED ELECTRICALLY-CHARGED PARTICLES OR OF NEUTRONS; PRODUCTION OR ACCELERATION OF NEUTRAL MOLECULAR OR ATOMIC BEAMS
- H05H3/00—Production or acceleration of neutral particle beams, e.g. molecular or atomic beams
- H05H3/06—Generating neutron beams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1085—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy characterised by the type of particles applied to the patient
- A61N2005/109—Neutrons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1092—Details
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
- A61N2005/1092—Details
- A61N2005/1094—Shielding, protecting against radiation
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E30/00—Energy generation of nuclear origin
- Y02E30/30—Nuclear fission reactors
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- Spectroscopy & Molecular Physics (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plasma & Fusion (AREA)
- Pathology (AREA)
- High Energy & Nuclear Physics (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Radiation-Therapy Devices (AREA)
- Particle Accelerators (AREA)
Abstract
The application provides a neutron capture treatment system, neutron capture treatment system is including the accelerator that is used for producing charged particle beam, the neutron production portion that produces neutron beam after the charged particle beam shines, the beam shaping body that carries out the plastic to the neutron beam, the beam shaping body includes the retarder and cladding in the reflector of retarder periphery, the neutron production portion produces the neutron after the charged particle beam shines, the retarder will be from neutron production portion neutron deceleration to predetermineeing the energy spectrum, the reflector is including the reflector that can lead back the neutron that deviates in order to improve the neutron intensity in the energy spectrum of predetermineeing and can form the support piece that supports to the reflector. The alloy material is arranged to support the lead material so as to overcome the creep effect of the lead material, and the structural strength of the beam shaping body is improved under the condition that the quality of the neutron beam is not affected.
Description
Technical Field
The present invention relates to a radiation therapy system, and more particularly to a neutron capture therapy system.
Background
With the development of atomic science, radiation therapy such as cobalt sixty, linac, electron beam, etc. has become one of the main means for cancer therapy. However, the traditional photon or electron treatment is limited by the physical condition of the radioactive rays, and a large amount of normal tissues on the beam path can be damaged while killing tumor cells; in addition, due to the different sensitivity of tumor cells to radiation, traditional radiotherapy often has poor therapeutic effects on malignant tumors with relatively high radiation resistance (such as glioblastoma multiforme (glioblastoma multiforme) and melanoma (melanoma)).
In order to reduce radiation damage to normal tissue surrounding a tumor, the concept of target treatment in chemotherapy (chemotherapy) has been applied to radiotherapy; for tumor cells with high radiation resistance, radiation sources with high relative biological effects (relative biological effectiveness, RBE) such as proton therapy, heavy particle therapy, neutron capture therapy, etc. are also actively developed. The neutron capture treatment combines the two concepts, such as boron neutron capture treatment, and provides better cancer treatment selection than the traditional radioactive rays by means of the specific aggregation of boron-containing medicaments in tumor cells and the accurate neutron beam regulation.
Boron neutron capture therapy (Boron Neutron Capture Therapy, BNCT) is carried out by using boron-containing 10 B) The medicine has the characteristic of high capture section for thermal neutrons by 10 B(n,α) 7 Li neutron capture and nuclear fission reaction generation 4 He (He) 7 Li two heavy charged particles. Referring to FIG. 1, which is a schematic diagram of a boron neutron capture reaction, the average energy of two charged particles is about 2.33MeV, the particles have high linear transfer (Linear Energy Transfer, LET) and short range characteristics, the linear energy transfer and range of alpha particles are 150keV/μm and 8 μm, respectively 7 The Li heavy charged particles are 175 keV/mum and 5μm, the total range of the two particles is approximately equal to one cell size, so that the radiation injury caused to organisms can be limited at the cell level, and when boron-containing medicaments are selectively gathered in tumor cells, the purpose of killing the tumor cells locally can be achieved on the premise of not causing too great injury to normal tissues by matching with a proper neutron source.
In accelerator boron neutron capture treatment, on the one hand, neutrons or other particles generated by a neutron generating section, such as gamma rays, are radioactive, and on the other hand, neutrons generated by the neutron generating section generally need to be subjected to beam shaping bodies to adjust the energy spectrum and improve neutron yield, so reflectors are required to be installed to reduce particle radiation leakage rate, adjust the energy spectrum and improve neutron yield. Lead or lead alloys are materials traditionally used for reflection or shielding, however, the creep effect of lead is significant and does not provide structural rigidity and long life. Lead alloys (such as lead-antimony alloys) can be used as stacked structures by adopting different additive proportions to reduce creep effect and improve structural strength. Bulk lead-antimony alloy stacks are commonly used for radiation shielding. For boron neutron capture treatment, neutron beam quality is related not only to the beam shaping body, but also to the reflector and shield. Because the antimony in the lead-antimony alloy has a high neutron absorption cross section, if the lead-antimony alloy is used as a reflecting layer, the quality of a neutron beam can be obviously reduced. If the stacked lead blocks are reflection layers, though the antimony with a high neutron absorption section is eliminated, the structural accuracy is insufficient due to the creep effect of the lead, and even the safety of the whole boron neutron capture treatment is affected.
Disclosure of Invention
In order to solve the above technical problem, an aspect of the present invention provides a neutron capture therapy system, which can improve the structural strength/accuracy of a beam shaper without significantly affecting the quality of a neutron beam. The neutron capture treatment system comprises an accelerator for generating a charged particle beam, a neutron generation part for generating a neutron beam after being irradiated by the charged particle beam, and a beam shaping body for shaping the neutron beam, wherein the beam shaping body comprises a retarder and a reflection part wrapping the periphery of the retarder, the neutron generation part generates neutrons after being irradiated by the charged particle beam, the retarder decelerates neutrons generated by the neutron generation part to a preset energy spectrum, and the reflection part comprises a reflector capable of guiding deviated neutrons back to improve neutron intensity in the preset energy spectrum and a support piece capable of supporting the reflector.
Further, the reflecting part comprises a plurality of cells, each cell forms a core part with a containing space, the plurality of core parts are connected to form the supporting piece, and the reflector is arranged in the containing space of the core part.
Further, the support piece is of an integrally formed structure, and the reflector material is arranged in the accommodating space of the core part in a casting mode.
As one preferable mode of the present invention, the reflector is formed by a modular design, specifically, a support member formed by connecting a predetermined number of cores is used, a top plate, a bottom plate, and a side plate connected to the top plate and the bottom plate and surrounding the outer periphery of the core are provided on the outer side of the support member, the predetermined number of cores connected, reflectors provided in the cores, the top plate, the bottom plate, and the side plate form a reflector module, and the reflector modules are stacked to form the reflector. In view of the convenience of stacking between subsequent reflector modules, the prescribed number is 20 in the present preferred embodiment.
In order to minimize the influence of the materials of the core, the top plate, the bottom plate and the side plates on the neutron beam quality, the materials of the core, the top plate, the bottom plate and the side plates are alloy materials with low neutron absorption cross section and low activation, and the total volume of the alloy materials accounts for less than 10% of the volume of the reflector material.
Preferably, the material of the reflector is lead, and the material of the core, the top plate, the bottom plate and the side plates is aluminum alloy or lead-antimony alloy.
In order to solve the above technical problem, another aspect of the present invention provides a neutron capture therapy system, which can improve the structural strength/accuracy of a beam shaper without significantly affecting the quality of a neutron beam. The neutron capture treatment device comprises an accelerator for generating a charged particle beam, a neutron generating part for generating a neutron beam after being irradiated by the charged particle beam, and a beam shaping body for shaping the neutron beam, wherein the beam shaping body comprises a retarder and a reflecting part wrapping the periphery of the retarder, the neutron generating part generates neutrons after being irradiated by the charged particle beam, the retarder decelerates neutrons generated by the neutron generating part to a preset energy spectrum, the reflecting part guides deviated neutrons back to improve neutron intensity in the preset energy spectrum, and the periphery of the reflecting part is further wrapped with a shielding part which comprises a supporting piece and a shielding body arranged in the supporting piece.
Further, the shielding part comprises a plurality of cells, each cell forms a core part with a containing space, the shielding body is arranged in the containing space of the core part, the plurality of core parts are connected to form the supporting piece, the supporting piece is of an integrated structure, and the shielding body is arranged in the containing space of the core part in a material pouring way.
As one preferable mode, the shielding part is designed in a modularized manner, specifically, a top plate, a bottom plate and side plates which are arranged oppositely are arranged on the outer sides of supporting pieces formed by connecting a specified number of cores, the side plates are connected with the top plate and the bottom plate and are arranged on the periphery of the core in a surrounding mode, the specified number of cores, shielding bodies, the top plate, the bottom plate and the side plates which are arranged in the cores form a shielding body module, the shielding body module is stacked to form the shielding part, the shielding body material is lead, the materials of the core, the top plate, the bottom plate and the side plates are low-neutron absorption cross section and low-activation materials, and the total volume of the materials of the core, the top plate, the bottom plate and the side plates accounts for less than 10% of the material volume of the reflector. The prescribed number in this application is 20 in view of convenience in stacking between subsequent shield modules.
Further, the reflecting part includes a reflector capable of guiding the deviated neutrons back to improve the neutron intensity in a preset energy spectrum and a support capable of supporting the reflector.
Compared with the prior art, the neutron capture treatment system supports the reflecting material or/and the shielding material through the support piece provided with the reflecting part or/and the support piece provided with the shielding part, namely supports the lead material through the alloy material with low neutron absorption and low activation so as to overcome the creep effect of the lead material, and improves the structural strength of the beam shaping body under the condition of not influencing the quality of neutron beams.
Drawings
FIG. 1 is a schematic representation of a boron neutron capture reaction of the present application;
FIG. 2 is a schematic view of a shield wall mounted neutron capture treatment system with a shield and only the shield having a support in accordance with a first embodiment of the present application;
fig. 3 is a schematic view of a core structure of the shielding part in the first embodiment of the present application;
FIG. 4 is an exploded view of a shielding module without shielding material in accordance with one embodiment of the present disclosure;
FIG. 5 is a schematic view of a shield wall mounted neutron capture treatment system in accordance with a second embodiment of the present application, wherein the beam shaping body has no shield and only the reflector has a support;
fig. 6 is a schematic view of a core structure of the reflecting portion in the second embodiment of the present application;
FIG. 7 is an exploded view of a reflector module without reflector material in a second embodiment of the present application;
FIG. 8 is a schematic view of a shield wall mounted neutron capture treatment system in accordance with a third embodiment of the present application, wherein both the reflector and the shield have supports.
Detailed Description
Particles (e.g., neutrons) generated by the accelerator require reflectors to reduce particle radiation leakage rate and shields to provide radiation safety shielding. Lead or lead alloys are materials traditionally used for reflection or shielding, however, the creep effect of lead is significant and does not provide structural rigidity and long life. Lead alloys (such as lead-antimony alloys) can be used as stacked structures by adopting different additive proportions to reduce creep effect and improve structural strength. Bulk lead-antimony alloy stacks are commonly used for radiation shielding. For boron neutron capture treatment, neutron beam quality is related not only to the beam shaping body, but also to the reflector and shield. Because the antimony in the lead-antimony alloy has a high neutron absorption cross section, if the lead-antimony alloy is used as a reflecting layer, the neutron quality can be obviously reduced. If the stacked lead blocks are reflection layers, though the antimony with a high neutron absorption section is eliminated, the structural accuracy is insufficient due to the creep effect of the lead, and even the safety of the whole boron neutron capture treatment is affected.
As shown in fig. 2, the present application provides a neutron capture therapy system 100, where the neutron capture therapy system 100 includes an accelerator 200 for generating a charged particle beam P, a neutron generating section 10 for generating a neutron beam after being irradiated by the charged particle beam P, a beam shaping body 20 for shaping the neutron beam, and a collimator 30. The beam shaping body 20 includes a retarder 21 and a reflecting portion 22 covering the periphery of the retarder. The neutron generator 10 irradiates with charged particle beams to generate neutron beams N, the retarder 21 retards the neutron beams N generated from the neutron generator 10 to a predetermined energy spectrum, the reflector 22 guides back the deviated neutrons to increase the neutron intensity in the predetermined energy spectrum, and the collimator 30 concentrates the neutrons generated by the neutron generator 10.
As an embodiment one, the neutron capture therapy system 100 further includes a shielding 40. Referring to fig. 3, the shielding part 40 includes a supporting member 41 and a shielding body 42 disposed in the supporting member 41. The supporting member 41 includes a plurality of cells 43, each cell 43 forms a core 45 having a receiving space 44, the shielding body 42 is disposed in the receiving space 44, and the plurality of cores 45 are connected to form the supporting member 41. As a preferred embodiment, the supporting member 41 is an integrally formed structure, and the shielding material is cast in the accommodating space 44 of each core 45 of the supporting member 41.
With reference to fig. 4, the support 41 is formed by joining a prescribed number of cores 45, the support 41 having a hexagonal cross section, which is easy to form and stack. A top plate 46 and a bottom plate 47, which are provided opposite to each other, and four side plates 48 connected to the top plate 46 and the bottom plate 47 and surrounding the outer periphery of the core 45 are provided on the outer side of the support 41. The prescribed number of connected cores 45, the shield 42 provided in the cores 45, the top plate 46, the bottom plate 47, and the side plates 48 form a shield module 49, and the shield module 49 is stacked to form the shield 40. In this application, the prescribed number is 20 as a preferred embodiment in view of convenience in stacking between the following shield modules 49. Of course, the number of the side plates can be adjusted according to design requirements by those skilled in the art, such as 3, 6, etc.; the prescribed number of shield modules, such as 10, 30, etc., is adjusted according to design requirements.
The material of the shielding body 42 is lead, and the top plate 46, the bottom plate 47, and the side plates 48 are made of alloy materials with low neutron cross section absorption and low neutron activation. To minimize the impact of the alloy material on the neutron beam quality, the total volume of the alloy material is less than 10% of the volume of the material of the shield 42.
In the present embodiment, the reflecting portion 22 is made of lead material and has a creep effect, the shielding portion 40 is wrapped around the reflecting portion 22, the beam shaping body 20 is embedded in a shielding wall W for shielding the radiation generated in the illumination chamber, the shielding portion 40 is directly supported on the shielding wall W, and the supporting member 41 inside the shielding portion 40 provides strength support for the reflecting portion 22 while providing support for the shielding body 42 itself, thereby improving the structural strength of the whole beam shaping body 20.
As shown in fig. 5, as the second embodiment, the arrangement of the shielding portion 40 in the first embodiment is directly applied to the reflecting portion 22, and the reflecting portion 22 is arranged in a structure including the supporting member 221 without providing the shielding portion 40.
Referring to fig. 6, the reflecting portion 22 includes a supporting member 221 and a reflector 222 disposed in the supporting member 221. The supporting member 221 includes a plurality of cells 223, each cell 223 forms a core 225 having a receiving space 224, the reflector 222 is disposed in the receiving space 224, and the plurality of cores 225 are connected to form the supporting member 221. As a preferred embodiment, the supporting member 221 is integrally formed, and the material of the reflector 222 is cast in the core 225 of the supporting member 221.
As shown in fig. 7, the reflecting portion 22 is modularized, specifically, a support 221 formed by connecting a predetermined number of cores 225 is used, and a top plate 226 and a bottom plate 227 which are provided opposite to each other and four side plates 228 which are connected to the top plate 226 and the bottom plate 227 and are provided around the outer periphery of the cores 225 are provided outside the support 221. The predetermined number of connected core portions 225, the reflectors 222 provided in the core portions 225, the top plate 226, the bottom plate 227, and the side plates 228 form a reflector module 229, and the reflector modules 229 are stacked to form the reflecting portion 22. The top plate 226, the bottom plate 227 and four side plates 228 connected with the top plate 226 and the bottom plate 227 and surrounding the periphery of the core 225 are made of alloy materials with low neutron cross section absorption and low activation, and the total volume of the alloy materials accounts for less than 10% of the volume of the material of the shielding body 42.
Fig. 8 shows a third embodiment of the present application, which is different from the above embodiment in that, in this embodiment, the reflective portion and the shielding portion are both configured with a supporting member, and in this embodiment, the reflective portion is disposed identically to the reflective portion in the second embodiment, and the shielding portion is disposed identically to the shielding portion in the first embodiment, which will not be described in detail. When the beam shaping body 20 is buried in the shielding wall W, the shielding portion 40 is directly supported by the shielding wall W, and in this embodiment, the reflector 222 is supported by the support 221 and the shielding body 42 is supported by the support 41 without affecting the quality of the neutron beam, so as to solve the problem of structural accuracy caused by creep effect of the reflector and the shielding body due to the adoption of lead materials.
It should be noted that, as described in the second embodiment and the third embodiment, when the reflecting portion is configured to have the reflector module, since the reflecting portion 22 is wrapped around the periphery of the retarder 21 and the outer surface of the retarder 21 is generally cylindrical or has at least one cone-shaped structure, when the reflecting portion formed by stacking the reflector modules 230 is wrapped around the outer surface of the retarder 21, the reflector module at the position directly combined with the surface of the retarder 21 should be structurally adjusted, for example, the reflector module at the contact portion with the retarder 21 is cut so that the reflecting portion is attached to the outer surface of the retarder 21, thereby not affecting the reflector 222 in the reflecting portion 22 to reflect the deviated neutrons.
The core formed by the cells in the present application may be any closed structure having a hole-shaped receiving space, such as a square, triangle or hexagon geometry in cross section, a tetrahedron, an octahedron or a dodecahedron having a hole-shaped receiving space, or a non-closed structure having a hole-shaped receiving space, which will not be illustrated herein. The lead is arranged in the hole-shaped accommodating space in a pouring mode and is tightly surrounded by the core material, so that the alloy material of the core forms a support for the lead material.
In the second embodiment and the third embodiment of the present application, in order to facilitate stacking and manufacturing of the reflector module and/or the shielding module, the core of the reflector and the core of the shielding portion both adopt a structure with a hexagonal cross section. Of course, the structure of the support of the reflecting portion may also be different from the structure of the support of the shielding portion. For example, the core structure of the support of the shielding part is of hexagonal geometry in cross section, while the core structure of the support of the reflecting part is of tetrahedral shape, as long as the alloy material of the support is able to form a support for the lead material and has a small influence on the quality of the beamlet, which will not be described in detail here.
In any of the above embodiments, for the weight of the whole beam shaping body, the materials of the core, the top plate, the bottom plate and the side plates connected with the top plate and the bottom plate and surrounding the periphery of the core are all made of light alloy materials, and in combination with the quality of the neutron beam, the materials of the core, the top plate, the bottom plate and the side plates are also made of low neutron absorption materials and low activation materials, and the total volume of the materials of the top plate, the bottom plate, the side plates and the core is less than 10% of the volume of the reflector material or the shielding body material. In the application, the materials of the top plate, the bottom plate, the side plates and the core part are preferably aluminum alloy materials. Lead-antimony alloys can also be used instead of aluminum alloys because, although the neutron absorption cross section of the lead-antimony alloy material is higher than that of the aluminum alloy material, the antimony in the lead-antimony alloy material also has no significant effect on the beamlet quality since the total volume of the materials of the top plate, bottom plate, side plates, and core is less than 10% of the volume of the reflector material or of the shield material, with an equivalent total antimony content of less than 1%.
Although the reflectors and/or shields in the beam shaping body are made of lead material with creep effect, when the beam shaping body is buried in the shielding wall W of the irradiation chamber, the structural accuracy of the whole beam shaping body is improved because the reflectors and/or shields supported on the shielding wall W can be supported on the lead material with creep effect by means of the support made of alloy material.
The utility model provides a shielding portion supports lead material through setting up alloy material on the one hand, and on the other hand sets up roof, hypoplastron and with roof, hypoplastron interconnect's curb plate in the lead material periphery that has alloy material to support, realizes the modularized design to the shielding portion when reinforcing shielding portion structural strength, simple structure, consequently, also can be applied to other shielding occasions with the shielding portion in this application.
The beam shaping body for neutron capture therapy disclosed in the present application is not limited to the structures described in the above embodiments and shown in the drawings. Obvious changes, substitutions, or modifications to the materials, shapes, and locations of the components therein are within the scope of the present application.
Claims (10)
1. A neutron capture therapy system, characterized by: the neutron capture treatment system comprises an accelerator for generating a charged particle beam, a neutron generation part for generating a neutron beam after being irradiated by the charged particle beam, and a beam shaping body for shaping the neutron beam, wherein the beam shaping body comprises a retarder and a reflection part wrapping the periphery of the retarder, the neutron generation part generates neutrons after being irradiated by the charged particle beam, the retarder decelerates neutrons generated by the neutron generation part to a preset energy spectrum, and the reflection part comprises a reflector capable of guiding deviated neutrons back to improve neutron intensity in the preset energy spectrum and a support piece capable of supporting the reflector.
2. The neutron capture therapy system of claim 1, wherein: the reflecting part comprises a plurality of cells, each cell forms a core part with a containing space, the plurality of core parts are connected to form the supporting piece, and the reflector is arranged in the containing space of the core part.
3. The neutron capture therapy system of claim 2, wherein: the supporting piece is of an integrated structure, and the reflector material is poured and arranged in the accommodating space of the core part.
4. The neutron capture therapy system of claim 2, wherein: the support member is formed by connecting a specified number of core parts, a top plate, a bottom plate and side plates which are oppositely arranged are arranged on the outer side of the support member, the side plates are connected with the top plate and the bottom plate and are arranged on the periphery of the core parts in a surrounding mode, the reflector module is formed by the specified number of connected core parts, reflectors arranged in the accommodating space of the core parts, the top plate, the bottom plate and the side plates, and the reflector module is stacked to form the reflecting part.
5. The neutron capture therapy system of claim 4, wherein: the materials of the core, the top plate, the bottom plate and the side plates are low neutron absorption cross sections and low activation materials, and the total volume of the materials of the core, the top plate, the bottom plate and the side plates accounts for less than 10% of the volume of the reflector materials.
6. The neutron capture therapy system of claim 5, wherein: the reflector is made of lead, and the core, the top plate, the bottom plate and the side plates are made of aluminum alloy or lead-antimony alloy.
7. A neutron capture therapy system, characterized by: the neutron capture treatment device comprises an accelerator for generating a charged particle beam, a neutron generating part for generating a neutron beam after being irradiated by the charged particle beam, and a beam shaping body for shaping the neutron beam, wherein the beam shaping body comprises a retarder and a reflecting part coated on the periphery of the retarder, the neutron generating part generates neutrons after being irradiated by the charged particle beam, the retarder decelerates neutrons generated by the neutron generating part to a preset energy spectrum, the reflecting part guides deviated neutrons back to improve neutron intensity in the preset energy spectrum, and the periphery of the reflecting part is further coated with a shielding part, and the shielding part comprises a supporting piece capable of supporting the reflector and a shielding body arranged in the supporting piece.
8. The neutron capture therapy system of claim 7, wherein: the shielding part comprises a plurality of cells, each cell forms a core part with a containing space, the shielding body is arranged in the containing space of the core part, the plurality of core parts are connected to form the supporting piece, the supporting piece is of an integrated structure, and the shielding body is arranged in the containing space of the core part in a material pouring way.
9. The neutron capture therapy system of claim 7, wherein: the support is formed by connecting a specified number of cores, a top plate, a bottom plate and side plates which are arranged oppositely are arranged on the outer side of the support, the side plates are connected with the top plate and the bottom plate and are arranged around the periphery of the core, the specified number of cores, a shielding body arranged in the core, the top plate, the bottom plate and the side plates form a shielding body module, the shielding body module is stacked to form the shielding part, the shielding body material is lead, the materials of the core, the top plate, the bottom plate and the side plates are low-neutron absorption cross sections and low-activation materials, and the total volume of the materials of the core, the top plate, the bottom plate and the side plates is less than 10% of the volume of the material of the reflector.
10. The neutron capture therapy system of claim 7, wherein: the reflecting part comprises a reflector capable of guiding the deviated neutrons back to improve the neutron intensity in a preset energy spectrum and a supporting piece capable of supporting the reflector.
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| CN201710733144.1A CN109420258B (en) | 2017-08-24 | 2017-08-24 | Neutron capture therapy system |
| CN202410064516.6A CN117839103A (en) | 2017-08-24 | 2017-08-24 | Beam shaping body |
| EP18847580.0A EP3666336B1 (en) | 2017-08-24 | 2018-08-15 | Neutron capture therapy system |
| JP2020509150A JP7175964B2 (en) | 2017-08-24 | 2018-08-15 | Neutron capture therapy system |
| RU2020109214A RU2743972C1 (en) | 2017-08-24 | 2018-08-15 | Neutron capture therapy system |
| PCT/CN2018/100572 WO2019037624A1 (en) | 2017-08-24 | 2018-08-15 | Neutron capture therapy system |
| EP21177917.8A EP3895760B1 (en) | 2017-08-24 | 2018-08-15 | Neutron capture therapy system |
| TW107129503A TWI683683B (en) | 2017-08-24 | 2018-08-23 | Neutron capture therapy system |
| US16/798,644 US11458336B2 (en) | 2017-08-24 | 2020-02-24 | Neutron capture therapy system comprising a beam shaping assembly configured to shape a neutron beam |
| US17/892,254 US11986680B2 (en) | 2017-08-24 | 2022-08-22 | Neutron capture therapy system comprising a beam shaping assembly configured to shape a neutron beam |
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| CN201710733144.1A CN109420258B (en) | 2017-08-24 | 2017-08-24 | Neutron capture therapy system |
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| TW201912201A (en) | 2019-04-01 |
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