CN109010665B - Traditional Chinese medicine composition for treating auto-allergic dermatitis and preparation method thereof - Google Patents

Traditional Chinese medicine composition for treating auto-allergic dermatitis and preparation method thereof Download PDF

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CN109010665B
CN109010665B CN201811208154.4A CN201811208154A CN109010665B CN 109010665 B CN109010665 B CN 109010665B CN 201811208154 A CN201811208154 A CN 201811208154A CN 109010665 B CN109010665 B CN 109010665B
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parts
decocting
chinese medicine
traditional chinese
medicine composition
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CN109010665A (en
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王继明
高用慧
王博迪
王嘉毅
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Tianjin Saierkang Biomedicine Technology Co ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/58Reptiles
    • A61K35/586Turtles; Tortoises, e.g. terrapins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489Sophora, e.g. necklacepod or mamani
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/54Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/65Paeoniaceae (Peony family), e.g. Chinese peony
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/75Rutaceae (Rue family)
    • A61K36/756Phellodendron, e.g. corktree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/90Smilacaceae (Catbrier family), e.g. greenbrier or sarsaparilla
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

Abstract

The invention relates to the technical field of treating allergic dermatitis, and discloses a traditional Chinese medicine composition for treating auto-allergic dermatitis, which comprises the following components in parts by weight: 10-16 parts of cimicifuga foetida, 20-30 parts of turtle shell, 10-18 parts of cassia twig, 12-15 parts of red paeony root, 12-15 parts of white paeony root, 22-35 parts of glabrous greenbrier rhizome, 8-15 parts of amur corktree bark and 8-18 parts of lightyellow sophora root; the traditional Chinese medicine composition has the advantages of quick response, short treatment course, treatment of both principal and secondary aspect of disease and good treatment effect; also provides a preparation method of the traditional Chinese medicine composition.

Description

Traditional Chinese medicine composition for treating auto-allergic dermatitis and preparation method thereof
Technical Field
The invention relates to the technical field of treating allergic dermatitis, and particularly relates to a traditional Chinese medicine composition for treating auto-allergic dermatitis and a preparation method thereof.
Background
Allergic dermatitis is a skin disease caused by allergens, and mainly refers to skin diseases such as red and swollen skin, itching, wheezy and desquamation and the like caused by contacting human bodies with certain allergens. Specific allergens can be classified into contact allergens, inhalation allergens, ingestion allergens and injection allergens. Each type of allergen can cause corresponding allergic reaction, and the main manifestations are various dermatitis, eczema and urticaria. The main clinical manifestations of allergic dermatitis are red, swollen, hot, painful, itchy, erythema, blisters, dandruff; causing serious impact on the normal life of the patient. The allergic dermatitis is often developed in four limbs, and the itching of the whole body is difficult to endure during the attack, so that large-area infection is caused if the skin is scratched; at present, western medicines are mostly adopted for treating allergic dermatitis for wiping and relieving, and the allergic dermatitis is easy to relapse and difficult to radically cure.
Disclosure of Invention
The invention aims to provide the traditional Chinese medicine composition for treating the auto-allergic dermatitis, and the traditional Chinese medicine composition has the advantages of quick response, short treatment course, treatment of both symptoms and root causes and good treatment effect; also provides a preparation method of the traditional Chinese medicine composition.
In order to achieve the purpose of the invention, the technical scheme adopted by the invention is as follows:
the traditional Chinese medicine composition for treating the auto-allergic dermatitis comprises the following components in parts by weight: 10-16 parts of cimicifuga foetida, 20-30 parts of turtle shell, 10-18 parts of cassia twig, 12-15 parts of red paeony root, 12-15 parts of white paeony root, 22-35 parts of glabrous greenbrier rhizome, 8-15 parts of golden cypress and 8-18 parts of lightyellow sophora root.
In the invention, further, the traditional Chinese medicine composition comprises the following components in parts by weight: 15 parts of cimicifuga foetida, 30 parts of turtle shell, 15 parts of cassia twig, 15 parts of red paeony root, 15 parts of white paeony root, 30 parts of glabrous greenbrier rhizome, 15 parts of golden cypress and 15 parts of lightyellow sophora root.
In the invention, further, the preparation method of the traditional Chinese medicine composition comprises the following steps: crushing carapax Trionycis, decocting with water for 10 min with strong fire, boiling, and slowly decocting with slow fire for 20 min; the other components are firstly added with water and soaked for 30 minutes in advance; mixing the two materials after decocting carapax Trionycis, decocting with strong fire for 10 min, boiling, and decocting with slow fire for 20 min to obtain medicinal liquid.
In the invention, further, the preparation method of the traditional Chinese medicine composition comprises the following steps: crushing carapax Trionycis, decocting with water 15-20 times of the total weight of carapax Trionycis, decocting with strong fire for 10 min, boiling, and decocting with slow fire for 20 min; adding water into the rest components, soaking for 30 min in advance, and adding water to a height higher than the components by 10-15 cm; mixing the two kinds of the raw materials, decocting carapax Trionycis, mixing the two kinds of raw materials, decocting with strong fire for 10 min, boiling, and decocting with slow fire for 20 min to obtain 300-500mL medicinal liquid.
The oral administration method of the formula of the invention comprises the following steps: the traditional Chinese medicine composition is taken half an hour after each meal in the morning and at night; taking 7 days continuously as a course of treatment, stopping taking for two days after seven days are finished, and taking the next course of treatment, wherein 4 courses of treatment are a cycle for 36 days in total. The course of treatment is 1-2 for mild patients, 3-5 for moderate patients, and 6-9 for severe patients.
The formula of the invention can be taken orally and can also be prepared into external medicaments.
Pulverizing carapax Trionycis, sieving with 100 mesh sieve, performing supercritical carbon dioxide extraction at 4-8 deg.C under 10-25MPa for 1-3 hr to obtain fat soluble extract; reflux-extracting the fat-soluble extract of carapax Trionycis with 95% anhydrous ethanol for 2-3h, filtering, and collecting filtrate; extracting the residue for 2-3 times, mixing filtrates, and vacuum rotary evaporating to remove solvent to obtain water soluble extract of carapax Trionycis.
Mixing the rest cimicifugae rhizoma, ramulus Cinnamomi, radix Paeoniae Rubra, radix Paeoniae alba, rhizoma Smilacis Glabrae, cortex Phellodendri, and radix Sophorae Flavescentis at a certain proportion, soaking in 10 times of 75% ethanol for 8-12 hr, heating and reflux-extracting for 2-3 hr, filtering, and collecting filtrate; removing ethanol under reduced pressure, decocting the residue with 10 times of water for 10 min with strong fire, boiling, and decocting with slow fire for 20 min to obtain 50-100mL medicinal liquid to obtain the Chinese medicinal extract.
Mixing the above two extracts, adding excipient, additive, and adjuvant, and making into medicinal liquid or unguent for wiping on skin surface.
In the present invention, further, the Chinese medicinal composition is used for treating the auto-allergic dermatitis.
The traditional Chinese medicine considers that: allergic dermatitis is caused by disorder of qi activity due to deficiency of body, improper diet, overstrain, mental stimulation and the like damaging the spleen and stomach, and is caused by exogenous pathogenic wind, heat, dampness and other pathogenic factors, so that the toxic factors invade skin, mucous membrane, even muscle, and are stagnated with qi and blood, body fluid, phlegm dampness and the like to generate heat for a long time, and the pathogenic factors of fire and heat are outward in nature, so that a way is necessarily found for a long time, and the disease is developed.
The formula of the invention is as follows:
cimicifugae foetidae: pungent, sweet and slightly cold; entering lung, spleen, large intestine and stomach meridians; relieving exterior syndrome, promoting eruption, clearing away heat and toxic materials, and invigorating yang;
turtle shell: salty taste, slightly cold nature; entering liver and kidney meridians; nourishing yin and suppressing yang, removing heat and removing steam, softening hardness and dissipating stagnation;
cassia twig: pungent, sweet and warm; entering lung, heart and bladder meridians; inducing sweat to relieve muscles, warming and dredging channels and collaterals, supporting yang and regulating qi;
red peony root: bitter taste and slightly cold nature; entering liver meridian; clearing heat and cooling blood, and removing blood stasis and relieving pain;
white peony root: three meridians of liver, spleen and lung; tonify blood, astringe yin, pacify liver and alleviate pain, and treat dizziness, chest and hypochondrium pain, dysentery, and menoxenia;
glabrous greenbrier rhizome: sweet, bland and mild; entering liver and stomach meridians; detoxify, remove dampness, and smooth joints;
phellodendron bark: bitter taste and cold nature; kidney, bladder channel; has effects in clearing away heat, eliminating dampness, purging pathogenic fire, removing steam, removing toxic materials, and treating sore;
flavescent sophora root: bitter taste and cold nature; the channels of heart, liver, stomach, large intestine and bladder; clearing heat, eliminating dampness, killing parasites and promoting urination;
the formula of the invention mainly uses turtle shell and cassia twig, has the functions of nourishing yin and suppressing yang, bringing down fever and removing steaming, warming and dredging channels and collaterals, nourishing liver and strengthening spleen, and soothing liver and regulating qi; cimicifugae rhizoma, radix Paeoniae Rubra, cortex Phellodendri, and radix Sophorae Flavescentis as adjuvants, and has effects of clearing heat, eliminating dampness, removing toxic substance, treating sore and promoting salivation, and also has effects of clearing heat, removing toxic substance, dispelling pathogenic wind, removing dampness, dispelling pathogenic wind, and relieving itching; radix Paeoniae alba and rhizoma Smilacis Glabrae can be added for flavoring, tonifying, replenishing blood, astringing yin, removing toxic substance, eliminating dampness, and smoothing joint movement; the eight Chinese herbal medicines act together, so that the internal part is effectively consolidated, the liver is nourished, the spleen is strengthened, and the liver is soothed and the qi is regulated; but also has the functions of clearing away heat and toxic material, dispelling wind and eliminating dampness, dispelling wind and relieving itching, and promoting blood circulation by removing blood stasis, promoting eruption and eliminating sore; therefore, the traditional Chinese medicine composition treats both principal and secondary aspects of diseases, and has the advantages of quick response, short treatment course and good treatment effect.
Drawings
FIG. 1 is a graph of the symptoms of the affected area in a clinical trial in which a mild patient had taken the formulation of the present invention before taking it.
FIG. 2 is a graph of the symptoms of the affected area after the mild patients had taken the formula of the present invention in a clinical trial.
FIG. 3 is a graph of symptoms in the affected area of a moderate patient in a clinical trial prior to administration of the formulation of the present invention.
FIG. 4 is a graph of the symptoms of the affected area in clinical trials of the moderate patients after taking the formula of the present invention.
Detailed Description
In order to make the technical means, the creation features, the achievement purposes and the effects of the invention easy to understand, the invention is further described with the embodiment. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
The raw materials used in the invention can be purchased from the market.
Example 1
A traditional Chinese medicine composition for treating the auto-allergic dermatitis comprises the following components: 10g of cimicifuga foetida, 20g of turtle shell, 10g of cassia twig, 12g of red paeony root, 12g of white paeony root, 22g of glabrous greenbrier rhizome, 8g of amur corktree bark and 8g of lightyellow sophora root.
The decocting method comprises the following steps: crushing carapax Trionycis, decocting with 300ml water for 10 min with strong fire, boiling, and slowly decocting with slow fire for 20 min; adding water into the other components, soaking for 30 minutes in advance, and adding water until the water content is 10cm higher than the components; mixing the two kinds of materials, decocting carapax Trionycis, mixing the two kinds of materials, decocting with strong fire for 10 min, boiling, and decocting with slow fire for 20 min to obtain 300mL medicinal liquid.
Example 2
A traditional Chinese medicine composition for treating the auto-allergic dermatitis comprises the following components: 12g of cimicifuga foetida, 22g of turtle shell, 10g of cassia twig, 14g of red paeony root, 12g of white paeony root, 25g of glabrous greenbrier rhizome, 10g of amur corktree bark and 10g of lightyellow sophora root.
The decocting method comprises the following steps: crushing carapax Trionycis, decocting with 400ml water for 10 min with strong fire, boiling, and slowly decocting with slow fire for 20 min; adding water into the other components, soaking for 30 minutes in advance, and adding water until the water content is 10cm higher than the components; mixing the two kinds of materials, decocting carapax Trionycis, mixing the two kinds of materials, decocting with strong fire for 10 min, boiling, and decocting with slow fire for 20 min to obtain 400mL medicinal liquid.
Example 3
A traditional Chinese medicine composition for treating the auto-allergic dermatitis comprises the following components: 15g of cimicifuga foetida, 30g of turtle shell, 15g of cassia twig, 15g of red paeony root, 15g of white paeony root, 30g of glabrous greenbrier rhizome, 15g of golden cypress and 15g of lightyellow sophora root.
The decocting method comprises the following steps: crushing carapax Trionycis, decocting with 500ml water for 10 min with strong fire, boiling, and slowly decocting with slow fire for 20 min; adding water into the rest components, soaking for 30 minutes in advance, and adding water to a height higher than the components by 12 cm; mixing the two kinds of materials, decocting carapax Trionycis, mixing the two kinds of materials, decocting with strong fire for 10 min, boiling, and decocting with slow fire for 20 min to obtain 400mL medicinal liquid.
Example 4
A traditional Chinese medicine composition for treating the auto-allergic dermatitis comprises the following components: 16g of cimicifuga foetida, 30g of turtle shell, 18g of cassia twig, 15g of red paeony root, 15g of white paeony root, 35g of glabrous greenbrier rhizome, 15g of golden cypress and 18g of lightyellow sophora root.
The decocting method comprises the following steps: crushing carapax Trionycis, decocting with 600ml water for 10 min with strong fire, boiling, and slowly decocting with slow fire for 20 min; adding water into the other components, soaking for 30 minutes in advance, and adding water until the water content is 15cm higher than the components; mixing the two kinds of materials, decocting carapax Trionycis, mixing the two kinds of materials, decocting with strong fire for 10 min, boiling, and decocting with slow fire for 20 min to obtain 500mL medicinal liquid.
A large number of clinical studies prove that the traditional Chinese medicine composition has the effects:
a total of 136 patients with acute and chronic recurrent allergic dermatitis were observed during 2005-2017, of which 84 women and 52 men all had a history of treatment with other methods, but all had recurrent features. Other treatment means are not used during the treatment period.
The treatment method comprises the following steps: the patients take the decoction obtained in the method of the embodiment 1 to 4 in batches to obtain the liquid medicine: the liquid medicine is taken twice, and is taken half an hour after one meal respectively in the morning and at night; taking 7 days continuously as a course of treatment, stopping taking for two days after seven days are finished, and taking the next course of treatment, wherein 4 courses of treatment are a cycle for 36 days in total. The course of treatment is 1-2 for mild patients, 3-5 for moderate patients, and 6-9 for severe patients.
The data are recorded, and the specific conditions and the treatment effects are shown in table 1:
TABLE 1
Figure GDA0003108853630000061
Figure GDA0003108853630000071
As can be seen from table 1 and accompanying drawings 1-4, the liquid medicine prepared in examples 1-4 of the present invention has very good relieving and repairing effects on allergic dermatitis, and after 1-2 treatment courses, symptoms and physical signs of mild patients are completely relieved, and patients who do not relapse after being diagnosed for 1 year; the moderate patients and the severe patients are also obviously improved after taking the liquid medicine, and the relapse is also reduced; although only 1 case is not cured, the discomfort symptoms and physical signs such as red swelling, pruritus and the like are obviously reduced; meanwhile, other uncomfortable conditions of the patient are not found in the experiment.
The invention is not limited to the foregoing embodiments. The invention extends to any novel feature or any novel combination of features disclosed in this specification and any novel method or process steps or any novel combination of features disclosed.

Claims (5)

1. The traditional Chinese medicine composition for treating the auto-allergic dermatitis is characterized by comprising the following components in parts by weight: 10-16 parts of cimicifuga foetida, 20-30 parts of turtle shell, 10-18 parts of cassia twig, 12-15 parts of red paeony root, 12-15 parts of white paeony root, 22-35 parts of glabrous greenbrier rhizome, 8-15 parts of golden cypress and 8-18 parts of lightyellow sophora root.
2. The traditional Chinese medicine composition for treating the auto-allergic dermatitis according to claim 1, which is prepared from the following components in parts by weight: 15 parts of cimicifuga foetida, 30 parts of turtle shell, 15 parts of cassia twig, 15 parts of red paeony root, 15 parts of white paeony root, 30 parts of glabrous greenbrier rhizome, 15 parts of golden cypress and 15 parts of lightyellow sophora root.
3. The traditional Chinese medicine composition for treating the auto-allergic dermatitis according to claim 1, wherein the traditional Chinese medicine composition is used for treating the auto-allergic dermatitis.
4. The preparation method of the traditional Chinese medicine composition for treating the auto-allergic dermatitis according to any one of claims 1 to 2, wherein the preparation method of the traditional Chinese medicine composition comprises the following steps: crushing carapax Trionycis, decocting with water for 10 min with strong fire, boiling, and slowly decocting with slow fire for 20 min; the other components are firstly added with water and soaked for 30 minutes in advance; mixing the two materials after decocting carapax Trionycis, decocting with strong fire for 10 min, boiling, and decocting with slow fire for 20 min to obtain medicinal liquid.
5. The preparation method of the traditional Chinese medicine composition for treating the auto-allergic dermatitis according to claim 4, wherein the preparation method of the traditional Chinese medicine composition comprises the following steps: crushing carapax Trionycis, decocting with water 15-20 times of the total weight of carapax Trionycis, decocting with strong fire for 10 min, boiling, and decocting with slow fire for 20 min; adding water into the rest components, soaking for 30 min in advance, and adding water to a height higher than the components by 10-15 cm; mixing the two kinds of the raw materials, decocting carapax Trionycis, mixing the two kinds of raw materials, decocting with strong fire for 10 min, boiling, and decocting with slow fire for 20 min to obtain 300-500mL medicinal liquid.
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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1090184A (en) * 1993-01-20 1994-08-03 陈煜超 A kind of Chinese medicine for outer use for the treatment of dermatitis and eczema
CN103638125A (en) * 2013-12-17 2014-03-19 王纯治 Traditional Chinese medicine compound for treating eczema and preparation method thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1090184A (en) * 1993-01-20 1994-08-03 陈煜超 A kind of Chinese medicine for outer use for the treatment of dermatitis and eczema
CN103638125A (en) * 2013-12-17 2014-03-19 王纯治 Traditional Chinese medicine compound for treating eczema and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
升麻鳖甲汤临床应用举隅;程群才;《国医论坛》;19891231(第5期);第22-23页 *

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