CN109010427B - Nasal mucosa moisturizing microemulsion and preparation method thereof - Google Patents
Nasal mucosa moisturizing microemulsion and preparation method thereof Download PDFInfo
- Publication number
- CN109010427B CN109010427B CN201811001834.9A CN201811001834A CN109010427B CN 109010427 B CN109010427 B CN 109010427B CN 201811001834 A CN201811001834 A CN 201811001834A CN 109010427 B CN109010427 B CN 109010427B
- Authority
- CN
- China
- Prior art keywords
- parts
- weight
- moisturizing
- microemulsion
- nasal mucosa
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Alternative & Traditional Medicine (AREA)
- Immunology (AREA)
- Dispersion Chemistry (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a nasal mucosa moisturizing microemulsion and a preparation method thereof, and solves the moisturizing microemulsion problem which is urgently needed in the field, is easy to achieve nasal mucosa moisturizing and is low in manufacturing cost. The composition comprises the following substances by weight based on 100 parts by weight: 0.1-5.5 parts of oil phase, 8-26 parts of surfactant, 8-26 parts of cosurfactant, 3.5-18 parts of humectant and 33-80 parts of distilled water. Taking 0.5-4 parts by weight of oil phase, 12-20 parts by weight of surfactant and 12-20 parts by weight of cosurfactant, mixing the oil phase, the surfactant and the cosurfactant, uniformly mixing and stirring the mixture by using a magnetic stirrer at the rotating speed of 800 plus 2000 rpm to obtain a primary uniform solution, uniformly mixing 7-15 parts by weight of humectant and 45-68 parts by weight of distilled water, adding the mixture into the primary uniform solution obtained in the first step, and uniformly stirring and mixing the mixture by using a magnetic stirrer at the rotating speed of 800 plus 2000 rpm to obtain the nasal mucosa moisturizing microemulsion. A low viscosity and high water locking peppermint oil nanoemulsion is provided.
Description
Technical Field
The invention relates to a nasal mucosa moisturizing microemulsion, in particular to a component of the nasal mucosa moisturizing microemulsion and a preparation method thereof.
Background
The nasal cavity is used as the first pass of respiration of human body, and has the functions of moistening, heating, removing dust, etc. The nasal mucosa is a layer of tissue structure covered on the inner wall surface of the nasal cavity, and has the functions of filtering, temperature regulation, moistening and the like. When the nasal cavity is invaded by cold, dry heat or pathogenic sources, the local part of the nasal mucosa can be stimulated, the nasal mucosa has self protection function, so that the local capillary vessels of the nasal mucosa expand hyperemia and secrete tissue fluid, the inhaled air is heated or moistened, and even the invading bacteria are killed. However, when the nasal mucosa is severely stimulated by external dry and cold air, dust and other pollutants, swelling of the nasal mucosa, increase and thickening of secretion, narrowing of nasal passages and irregular ciliary movement can cause phenomena such as nasal obstruction, breathing disorder, olfactory disturbance and the like, and even upper respiratory tract infection, stimulation symptoms and allergic symptoms can be caused to induce the attack of nasosinusitis, allergic rhinitis, tonsillitis, bronchitis, asthma or pneumonia. Therefore, moisturizing and nursing of the nasal mucosa are important.
In recent years, the incidence of diseases caused by dryness of the nasal mucosa has increased remarkably, and one of the reasons is that: due to the dry climate, the phenomena of haze and dust raising caused by wind and sand in winter frequently occur; the second reason is that: clinically, patients with general vasoconstrictors, laser and microwave therapy, vitamin deficiency or chronic diseases are also easy to induce nasal mucosa dryness. For treating rhinitis sicca, the prior art adopts normal saline, peppermint oil, liquid paraffin and compound menthol nasal drops to be applied to the nose. The traditional compound menthol nasal drop is prepared by adding a small amount of peppermint oil, borneol and the like into paraffin oil, and the paraffin oil is used as a humectant to form an oily film on the surfaces of skin, mucous membrane and the like, so that the loss of water is inhibited, and the moisturizing effect is exerted. However, the oily moisturizer has poor air permeability, low comfort level and poor medication compliance. The peppermint oil is colorless or light yellow clear liquid, has special cool fragrance, can lubricate nasal mucosa, stimulate nerve endings, promote the nasal mucosa to recover secretion function and the like; chinese patent specification CN200610166430.6 discloses a peppermint oil microemulsion preparation with slow release for improving food, cosmetics and cigarette fragrance, the related compound emulsifier components are relatively complex, and no moisturizing component is contained; preparation of peppermint oil microemulsion gel, as described in the section of 2018, volume 29, No. 3 of Shizhen national medicine & supplement to emulsifier ratio Km1, the proportion of the emulsifier is relatively high, the average grain diameter of the peppermint oil microemulsion gel is 117.3 +/-7.73 nanometers, the peppermint oil microemulsion gel belongs to a submicron emulsion preparation, and no moisturizing component or nasal mucosa moisturizing function is involved; the peppermint oil microemulsion published in No. 24, No. 3, food and machinery, 2008 is mainly applied to porous starch solidification and cigarettes, and does not relate to moisturizing components and a nasal mucosa moisturizing effect. How to seek a nasal mucosa moisturizing microemulsion preparation which has low preparation cost, simple and convenient operation and easy realization becomes an important problem which needs to be solved urgently in the field.
Disclosure of Invention
The invention provides a nasal mucosa moisturizing microemulsion and a preparation method thereof, and solves the technical problems of moisturizing microemulsions which are urgently needed in the field, easy to achieve nasal mucosa moisturizing and low in manufacturing cost.
The invention solves the technical problems by the following technical scheme:
the nasal mucosa moisturizing microemulsion contains the following substances by weight of 100 parts: 0.1-5.5 parts of oil phase, 8-26 parts of surfactant, 8-26 parts of cosurfactant, 3.5-18 parts of humectant and 33-80 parts of distilled water.
Based on 100 parts by weight, the oil-soluble polymer emulsion contains 0.5-4.5 parts by weight of oil phase, 10-22 parts by weight of surfactant, 10-22 parts by weight of cosurfactant, 5-15 parts by weight of humectant and 40-73 parts by weight of distilled water.
The oil phase is peppermint oil, the surfactant is Tween 80 or Tween 60 or polyoxyethylene hydrogenated castor oil or sodium dodecyl sulfate, the cosurfactant is polyethylene glycol 400 or glycerol or 1, 2-propylene glycol or absolute ethyl alcohol, and the humectant is glycerol or paraffin oil or sorbitol.
A preparation method of nasal mucosa moisturizing microemulsion comprises the following steps:
taking 0.5-4 parts by weight of oil phase, 12-20 parts by weight of surfactant and 12-20 parts by weight of cosurfactant based on 100 parts by weight, mixing the oil phase, the surfactant and the cosurfactant, and then uniformly stirring and mixing the mixture by adopting a magnetic stirrer at the rotating speed of 800 plus 2000 revolutions per minute to obtain a primary uniform solution;
and step two, uniformly mixing 7-15 parts by weight of humectant and 45-68 parts by weight of distilled water based on 100 parts by weight, adding the mixture into the primary uniform solution obtained in the step one, and uniformly stirring and mixing the mixture by using a magnetic stirrer at the rotating speed of 800 plus 2000 revolutions per minute to obtain the nasal mucosa moisturizing microemulsion.
The primary homogeneous solution obtained in the first step is obtained by adding 1-4 parts by weight of oil phase, 12-20 parts by weight of surfactant, 12-20 parts by weight of cosurfactant and 45-65 parts by weight of distilled water and mixing based on 100 parts by weight; the nasal mucosa moisturizing microemulsion obtained in the second step is obtained by adding 8-15 parts by weight of moisturizing agent into the primary uniform solution obtained in the first step, and uniformly mixing by magnetic stirring.
Taking 100 parts by weight of oil phase, 12-20 parts by weight of surfactant, 12-20 parts by weight of cosurfactant, 8-15 parts by weight of humectant and 45-65 parts by weight of distilled water, mixing, and magnetically stirring at the rotating speed of 900 plus 2000 revolutions per minute to obtain the nasal mucosa microemulsion moisturizing agent.
The invention introduces the humectant into a microemulsion system, provides the dementholized peppermint oil nanoemulsion with low viscosity and high water locking, is applied to the moisturizing effect of discomfort caused by dryness and allergy of nasal mucosa caused by dryness and itching of nose, occupation, climate, environment and other factors, protects the first defense line of a good respiratory tract, and plays a due role in reducing or avoiding the occurrence of upper respiratory tract diseases.
Detailed Description
The present invention is described in detail below:
example one
A preparation method of nasal mucosa moisturizing microemulsion comprises the following steps:
step one, taking 1 part by weight of peppermint oil, 14 parts by weight of tween 80 and 14 parts by weight of absolute ethyl alcohol according to 100 parts by weight, mixing, and then stirring and mixing uniformly by using a magnetic stirrer at the rotating speed of 900-;
step two, mixing 10 parts by weight of sorbitol and 61 parts by weight of distilled water according to 100 parts by weight, adding the mixture into the primary uniform solution obtained in the step one, and stirring the mixture for 2 hours at a magnetic stirring speed of 1000 revolutions per minute until clear and transparent nasal mucosa moisturizing microemulsion is obtained;
example two
A preparation method of nasal mucosa moisturizing microemulsion comprises the following steps:
taking 4 parts by weight of dementholized peppermint oil, 18 parts by weight of polyoxyethylene hydrogenated castor oil, 18 parts by weight of polyethylene glycol 400, 9 parts by weight of paraffin oil and 51 parts by weight of distilled water, mixing, and continuously stirring for 1.5 hours by using a magnetic stirrer at the rotating speed of 1500 revolutions per minute until clear and transparent nasal mucosa moisturizing microemulsion is obtained;
EXAMPLE III
A preparation method of nasal mucosa moisturizing microemulsion comprises the following steps:
taking 15 parts by weight of sodium dodecyl sulfate, 15 parts by weight of 1, 2-propylene glycol, 2 parts by weight of peppermint oil and 56 parts by weight of distilled water, mixing, and then uniformly stirring and mixing at a rotating speed of 2000 revolutions per minute by adopting a magnetic stirrer to obtain a primary uniform solution;
secondly, taking 12 parts by weight of glycerol based on 100 parts by weight, adding the glycerol into the primary uniform solution obtained in the first step, and stirring for 1 hour at a magnetic stirring speed of 2000 revolutions per minute until clear and transparent nasal mucosa moisturizing microemulsion is obtained;
the preparation process is optimized, multiple factors such as particle size, Zeta potential, turbidity and viscosity are used as evaluation indexes, a single-factor test method is adopted, the influence of stirring time, stirring speed and a feeding mode on the preparation process of the moisturizing microemulsion is investigated, a magnetic stirrer is used for investigating the stirring time after the components are mixed within the range of 0.5, 1, 1.5, 2 and 2.5 hours, and the optimized stirring time is 1.0-2.5 hours; the stirring speed of the magnetic stirrer after the components are mixed is considered within the range of 400, 800, 1200, 1600 and 2000 revolutions per minute, and the optimized stirring speed is 800 and 2000 revolutions per minute; the investigation of the feeding mode is carried out: mixing oil and an emulsifier, and adding other components; ② after the auxiliary emulsifier is mixed with oil, adding other components; mixing all the ingredients; and fourthly, adding oil after the emulsifier and the co-emulsifier are mixed, and finding that the four feeding modes can prepare the satisfactory moisturizing microemulsion. Under the optimized process conditions, the prepared moisturizing microemulsion is detected to show that: the moisture-retaining microemulsion has the advantages that the turbidity change is not obvious, the Zeta potential change is small, the viscosity change difference is small, the average particle size is 10-100 nm, and the requirement is met; the multi-index evaluation result shows that the preparation process is stable and feasible, the quality is controllable, and the satisfactory moisturizing microemulsion can be prepared.
The invention carries out the formulaThe proportion optimization works by selecting peppermint oil as an oil phase and the proportion of the emulsifier and the co-emulsifierK mSelecting the values as 2:1, 1:1 and 1:2 respectively, carrying out tests, and judging the end point by a titration method; resultsK mThe results were satisfactory at a value of 1: 1. On the basis, the proportion of each component of the microemulsion including the humectant is tested in the same way.
The invention carries out the determination of the moisture-retaining microemulsion content: the total oil amount of the dementholized peppermint oil in the moisturizing microemulsion is measured by an ultraviolet spectrophotometry. The ultraviolet detection wavelength is 227 nanometers, and the content of the moisturizing microemulsion is measured by taking peppermint oil as a reference. The total amount of the peppermint oil in the moisturizing microemulsion is not less than 10 mg/ml through determination; the method is simple and feasible, has accurate and reliable measurement result, and is suitable for measuring the total oil content of the peppermint oil in the moisturizing microemulsion. ② measuring the menthol content in the moisture-keeping microemulsion by gas chromatography. The chromatographic conditions were as follows: high performance capillary gas chromatography column (TP-FFAP, 30m × 0.320mm × 0.25 μm); nitrogen gas is used as carrier gas, and the flow rate is as follows: 3 ml/min; sample introduction amount: 1 mul; sample inlet temperature: 250 ℃, detector temperature: 250 ℃; temperature rising procedure: the initial temperature is 60 deg.C, maintaining for 2 min, raising to 100 deg.C at 20 deg.C/min, maintaining for 1 min, raising to 180 deg.C at 12 deg.C/min, and maintaining for 1 min; the split ratio is 10: 1; under the chromatographic conditions, measuring the content of the moisturizing microemulsion by taking menthol as a reference substance and ethyl salicylate as an internal standard, wherein the content of the menthol in the moisturizing microemulsion is not lower than 1.5 mg/ml through measurement; the method is used for measuring the content of menthol in the moisturizing microemulsion, has accurate and reliable measuring result, and can be used for quality control of preparation.
The microemulsion is used as a novel drug carrier and has the characteristics of thermodynamic stability, rapid absorption, targeted drug release and the like. The invention utilizes the microemulsion technology to prepare the dementholized peppermint oil into the microemulsion, and the microemulsion has good water locking and moisturizing effects. The nasal administration has the characteristics of quick absorption, convenient use, avoidance of liver first pass effect, realization of targeted delivery and the like. In order to avoid nasal mucosa injury, nasal obstruction, nasal itching, nasal dryness and the like caused by the stimulation of external dry and cold air, dust, pm2.5, overdose, long-term oxygen therapy and other physical or chemical factors. By using the product of the patent, the nasal cavity is not only kept moist, but also cleaned and nursed, the side effects of dryness, rupture and even bleeding of the nasal mucosa caused by the existing nasal spray medicine are effectively improved, the respiratory diseases are reduced, the life quality of people is improved, better prevention and treatment effects are achieved, and a new effective method is provided.
Claims (1)
1. A preparation method of nasal mucosa moisturizing microemulsion comprises the following steps:
taking 0.5-4 parts by weight of dementholized peppermint oil, 12-20 parts by weight of emulsifier, wherein the emulsifier is Tween 80 or Tween 60 or polyoxyethylene hydrogenated castor oil or sodium dodecyl sulfate, 12-20 parts by weight of co-emulsifier is polyethylene glycol 400 or glycerol or 1, 2-propylene glycol or absolute ethyl alcohol, and the ratio of the emulsifier to the co-emulsifier is 100 parts by weightK mThe ratio is 1:2, and after the components are mixed, the mixture is uniformly mixed and stirred by a magnetic stirrer at the rotating speed of 800-;
and secondly, taking 100 parts by weight of humectant, namely glycerol or sorbitol, and 45-68 parts by weight of distilled water, uniformly mixing, adding the mixture into the primary uniform solution obtained in the first step, stirring the mixture for 1-2.5 hours by using a magnetic stirrer at the rotating speed of 800 plus 2000 rpm, and uniformly stirring and mixing to obtain the oil-in-water nasal mucosa moisturizing microemulsion with the average particle size of 10-100 nm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811001834.9A CN109010427B (en) | 2018-08-30 | 2018-08-30 | Nasal mucosa moisturizing microemulsion and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811001834.9A CN109010427B (en) | 2018-08-30 | 2018-08-30 | Nasal mucosa moisturizing microemulsion and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN109010427A CN109010427A (en) | 2018-12-18 |
| CN109010427B true CN109010427B (en) | 2021-06-08 |
Family
ID=64625537
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811001834.9A Active CN109010427B (en) | 2018-08-30 | 2018-08-30 | Nasal mucosa moisturizing microemulsion and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109010427B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112076148A (en) * | 2019-06-12 | 2020-12-15 | 陕西佰傲再生医学有限公司 | Nasal antiallergic gel and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103126934A (en) * | 2013-03-12 | 2013-06-05 | 昆山威胜干燥剂研发中心有限公司 | Seabuckthorn montmorillonite liquid soap and preparation method thereof |
| CN103230386A (en) * | 2013-04-18 | 2013-08-07 | 徐州医学院 | Clean-free skin and hand micro-emulsion disinfectant agent and preparation method thereof |
| CN107669513A (en) * | 2017-08-24 | 2018-02-09 | 山西医科大学 | A kind of olive oil with skin care bacteriostasis/VE micro emulsion gels and preparation method thereof |
-
2018
- 2018-08-30 CN CN201811001834.9A patent/CN109010427B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103126934A (en) * | 2013-03-12 | 2013-06-05 | 昆山威胜干燥剂研发中心有限公司 | Seabuckthorn montmorillonite liquid soap and preparation method thereof |
| CN103230386A (en) * | 2013-04-18 | 2013-08-07 | 徐州医学院 | Clean-free skin and hand micro-emulsion disinfectant agent and preparation method thereof |
| CN107669513A (en) * | 2017-08-24 | 2018-02-09 | 山西医科大学 | A kind of olive oil with skin care bacteriostasis/VE micro emulsion gels and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 微乳基质成乳条件与稳定性的研究;史同瑞等;《动物医学进展》;20060120(第07期);第97-99页 * |
| 薄荷油微乳凝胶的制备研究;周雪;《时珍国医国药》;20180331;第 29 卷(第 3 期);第587页右栏最后1段、第588页左栏第1段、第2.1部分内容、第589页左栏最后1段及右栏第1段 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN109010427A (en) | 2018-12-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Munakata et al. | Osmotic stimuli induce epithelial-dependent relaxation in the guinea pig trachea | |
| JP2007056039A (en) | Method and device for provocation of air passage narrowing and/or induction of sputum | |
| Fine et al. | Mechanism by which glucose stimulates the passive absorption of small solutes by the human jejunum in vivo | |
| Hommoss et al. | Mucoadhesive tetrahydrocannabinol-loaded NLC–Formulation optimization and long-term physicochemical stability | |
| Allegra et al. | High altitude exposure reduces bronchial responsiveness to hypo-osmolar aerosol in lowland asthmatics | |
| CN109010427B (en) | Nasal mucosa moisturizing microemulsion and preparation method thereof | |
| JPH06271471A (en) | Bio-function controlling substance | |
| CN112516087B (en) | Budesonide nasal spray and preparation method thereof | |
| CN106421039A (en) | Traditional Chinese medicine composition for preventing and treating haze-caused diseases, preparation method thereof and mask containing traditional Chinese medicine | |
| CN105434337A (en) | Propranolol hydrochloride submicron emulsion gel and preparation method and application thereof | |
| CN101524325B (en) | Compound menthol microemulsion and preparation for nose | |
| CN107260667A (en) | Menthol spray agent and its application prepared by a kind of menthol Submicron Emulsion | |
| KR101971574B1 (en) | Cosmetic composition for improving sleep disorder or maintaining deep sleep comprising withania somnifera, morus australis and pure tea extracts | |
| CN103263408A (en) | Allicin nano liposome and preparation method and application thereof | |
| WO2001008671A2 (en) | Method and composition for prophylaxis and treatment of symptoms associated with cold and influenza-like illnesses | |
| CN110088073A (en) | For treating the method and composition of atopic dermatitis | |
| JP5362998B2 (en) | Dry liposome preparation | |
| Liang et al. | Preparation and quality evaluation of a volatile oil microemulsion from Flos magnoliae and Centipeda minima | |
| EP1957121B1 (en) | Acute treatment of social phobia with an androsta-4,16-dien-3-ol steroid | |
| CN111557900A (en) | Cannabidiol cream, preparation method and application thereof | |
| Selden et al. | Marijuana | |
| CN117224518B (en) | Application of sofalcone in preparation of medicine for preventing/treating allergic asthma | |
| P'an | Distribution of sulfanilamide in the ocular fluids and tissues after local application | |
| TWI774331B (en) | Fermented product of michelia alba and oat, method of manufacturing the same and topical composition including the same | |
| CN116440080A (en) | Safflower yellow nanometer flexible liposome and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |