CN108982893A - A kind of liquid detection device in active immunity work station - Google Patents
A kind of liquid detection device in active immunity work station Download PDFInfo
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- CN108982893A CN108982893A CN201810526143.4A CN201810526143A CN108982893A CN 108982893 A CN108982893 A CN 108982893A CN 201810526143 A CN201810526143 A CN 201810526143A CN 108982893 A CN108982893 A CN 108982893A
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- plunger pump
- sampling
- pipeline
- connection
- solenoid valve
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- 239000007788 liquid Substances 0.000 title claims abstract description 31
- 238000001514 detection method Methods 0.000 title claims abstract description 18
- 230000036039 immunity Effects 0.000 title claims abstract description 8
- 238000005070 sampling Methods 0.000 claims abstract description 44
- 230000007246 mechanism Effects 0.000 claims abstract description 32
- 238000004891 communication Methods 0.000 abstract description 5
- 238000012360 testing method Methods 0.000 abstract description 5
- 238000012864 cross contamination Methods 0.000 abstract description 3
- 238000002474 experimental method Methods 0.000 abstract description 3
- 238000010339 medical test Methods 0.000 abstract description 3
- 230000009286 beneficial effect Effects 0.000 abstract description 2
- 238000000034 method Methods 0.000 description 12
- 239000012530 fluid Substances 0.000 description 5
- 230000033001 locomotion Effects 0.000 description 5
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 230000005540 biological transmission Effects 0.000 description 2
- 230000005611 electricity Effects 0.000 description 2
- 230000008676 import Effects 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- 238000002965 ELISA Methods 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 241000009298 Trigla lyra Species 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005213 imbibition Methods 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
- G01N2035/1025—Fluid level sensing
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- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Sampling And Sample Adjustment (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
A kind of liquid detection device in active immunity work station, belong to medical test, food testing, biological experiment equipment technical field, it is characterized in that: being equipped with plunger pump on sampling arm crossbeam, plunger pump is fixed with sampling arm crossbeam, solenoid valve is connected with a connecting pin of plunger pump housing, it is fixed by screws on plunger pump, sampling head bindiny mechanism is perpendicularly fixed at sampling arm crossbeam, sampling head bindiny mechanism is connect with plunger pump by hose, has pressure sensor to be connected in pipeline in the pipeline of connection.Beneficial effect is: 1, avoiding the risk of cross contamination.2, the consumables cost of instrument is reduced.3, plunger pump is directly fixed on sampling crossbeam, shortens the connection length of tube with sampling head bindiny mechanism, improves sampling precision.4, using solenoid valve control pipeline and air communication, loine pressure is directly returned to initial air pressure after plunger pump is opened, and will not cause the pressure change in pipeline because of the reset of plunger pump.
Description
Technical field
The invention belongs to medical test, food testing, biological experiment equipment technical fields.
Background technique
During medical test, food testing, biological experiment, ELISA and CLIA are the normal of clinical labororatory's progress
Advise the method for inspection, current checkout procedure is, the addition of sample and reagent is carried out on 96 orifice plates, be then incubated for, board-washing,
The work such as DATA REASONING, the link workload maximum of this and reagent of sample-adding, is loaded precision and position is accurate in the whole process
Degree plays critical effect in entire detection process.This and reagent of domestic sample-adding mainly departure work and automatic sample two at present
Kind method.Since condition limits, sample-adding process there are load position and adds middle-size and small-size medical institutions of China all by having been manually done
Phenomena such as sample trueness error, influence testing result.And there is somewhat expensives, consumables cost for the automatic sample-adding system of import
The high, drawbacks such as volume is big, complicated for operation, maintenance cost is high, hardly result in universal.
Sampling mechanism is core in automatic sample-adding system, and accuracy is not in terms of imbibition, liquid separation for existing domestic equipment
Height, and overseas equipment is expensive.Furthermore existing loading device is there is also cross contamination between sample is easy to appear, sternly
Ghost image rings the quality for examining work.
Summary of the invention
The object of the present invention is to provide the liquid detection devices in a kind of active immunity work station, it can be improved automatically
The sample-adding precision and load position accuracy of sample adding system, while using common disposable TIP head, testing cost is reduced, is overcome
Cross contamination.Sampling mechanism at lower cost realizes the work of the high speed, high quality of automatic sampling system.
The technical scheme is that being equipped with plunger pump on sampling arm crossbeam, plunger pump and sampling arm crossbeam are solid
Fixed, solenoid valve is connected with a connecting pin of plunger pump housing, is fixed by screws on plunger pump, sampling head bindiny mechanism
It is perpendicularly fixed at sampling arm crossbeam, sampling head bindiny mechanism is connect with plunger pump by hose, has pressure in the pipeline of connection
Sensor is connected in pipeline.
Solenoid valve is two-way valve, and wherein one end realizes the connection of plunger pump airtight cavity and solenoid valve by connection hose；
The other end is by the connection of connection hose and air, and when solenoid valve is closed, plunger pump airtight cavity and air are disconnected, and works as electromagnetism
When valve is opened, plunger pump airtight cavity and air communication.
There are two connectors for pressure sensor, are connected in plunger pump airtight cavity and sampling head bindiny mechanism, use
Carry out the pressure in signal piping.
Sampling head bindiny mechanism is conical tube.
The beneficial effects of the present invention are: 1, avoid at present the steel needle employed in most of instruments sampling brought by hand over
Pitch the risk of pollution.2, the high of the disposable conductive plastic sampling head for relying primarily on import at present is avoided using common sampling head
Expensive price (price of conductive sampling head is ten times of conventional needle or so), reduces the consumables cost of instrument.3, plunger pump
It is directly fixed on sampling crossbeam, shortens the connection length of tube with sampling head bindiny mechanism, improve sampling precision.4, using electricity
Magnet valve control piper and air communication, loine pressure is directly returned to initial air pressure after plunger pump is opened, will not be because of
The reset of plunger pump causes the pressure change in pipeline.
Detailed description of the invention
Fig. 1 is structural schematic diagram of the invention；
Fig. 2 is the flow chart of Application Example of the invention；
Fig. 3 is a kind of level detection analogue signal amplitude-displacement waveform diagram of embodiment of the invention.
Specific embodiment
The present invention is described further with reference to the accompanying drawing:
As shown in Figure 1,1 stepper motor；2 linear transmission mechanisms；3 plunger pump housings；4 plunger pump rubber stoppers；5 solenoid valves；6 plungers
Pump airtight cavity；7 connection hoses realize the connection of plunger pump airtight cavity and solenoid valve；8 connection hoses, realize solenoid valve and sky
The connection of gas；9 connection hoses, realize the connection of plunger pump airtight cavity and pressure sensor；10 pressure sensors；11 connections are soft
Pipe, realizes the connection of pressure sensor Yu sampling head bindiny mechanism；12 sampling head bindiny mechanisms；13 disposable sampling heads；14
Sample to be tested；15 sample tubes；16 sampling arm crossbeams.
The present invention can be used for detecting the detecting liquid level mechanism of liquid level, and the fluid path for maintaining the gas in air cavity constant is clear
Washing machine structure, for controlling the control system of detecting liquid level mechanism and fluid path wiper mechanism, the detecting liquid level mechanism, the liquid
Road wiper mechanism is connected with the control system respectively.
Specifically, it as shown in Figure 1, all components are all mounted on sampling arm crossbeam 16, is moved down on sampling arm crossbeam 16
Dynamic and rotation, to drive whole device to be moved.The detecting liquid level mechanism 1 is stepper motor, passes through turning for stepper motor 1
It is dynamic to drive linear transmission mechanism 2, to realize the movement of plunger pump rubber stopper 4.The movement of plunger pump rubber stopper 4 causes column
The volume change of plug pump airtight cavity 6.The volume change of plunger pump airtight cavity 6 realize by connection pipeline carry out inhale sample and
Setting-out.
The solenoid valve 5 is two-way valve, and wherein plunger pump airtight cavity and solenoid valve are realized by connection hose 7 in one end
Connection.The other end is by the connection of connection hose 8 and air, and when solenoid valve is closed, plunger pump airtight cavity 6 and air are disconnected
It opens, when solenoid valve 5 is opened, plunger pump airtight cavity 6 and air communication.
There are two connectors for the pressure sensor 10, are connected to plunger pump airtight cavity 6 and connect with sampling head
In mechanism 12, for the pressure in signal piping.
The positive upper end of sample tube 15, when being detected, sampling arm crossbeam are in the original state whole device of detection
16 drive whole device decline, move closer to sample to be tested 14.It carries out the movement of stepper motor 15 simultaneously and passes through pressure sensing
Device 10 carries out signal detection.When by software detection to liquid level, 16 stop motion of sampling arm crossbeam, disposable sampling head at this time
It 13 lower end should be below the liquid level of sample to be tested 14.Solenoid valve 5 is opened later, and stepper motor 15 continues to run drive column
Plug pump rubber stopper 4 moves to the bottom of plunger pump airtight cavity 6, be then shut off solenoid valve 5, at this time plunger pump airtight cavity 6
Volume is minimum.Detecting liquid level terminates, and can carry out inhaling sample operation.
The present invention also provides a kind of detection methods based on liquid level sensor described above, wherein including following step
It is rapid:
Crossbeam moves down S1 distance to plunger pump operation simultaneously in the present invention, needs to be set according to different sample tubes.
Threshold value △ V in the present invention needs to be set according to different use environment and specific model.
The present invention also provides a kind of level detection analogue signal amplitude-positions of the concrete application embodiment of liquid level checking method
Waveform diagram is moved, as shown in figure 3, wherein remaining static in the mechanism of △ t1 period entirety, the pressure value of detection is
0.51V or so.The △ t2 period is plunger pump operation, while crossbeam runs down the stage, due to the body of plunger pump airtight cavity 6
Product becomes smaller, and has gas to be uniformly discharged in pipeline, and the pressure in pipeline is 0.55V or so at this time.The △ t3 period is disposably to take
Sample head 13 enters liquid level hereinafter, plunger pump continues to run at this time, and pressure becomes larger, and is 0.58V or so.The △ t4 period is electricity
Magnet valve 5 is opened, at this time plunger pump airtight cavity and air communication, the pressure recovery that pressure sensor 10 detects to the left side 0.51V
It is right.
The present invention also provides a kind of flow charts of the Application Example of liquid level checking method, as shown in Fig. 2, the method
Include:
Step a1, start, execute step a2 later;
Step a2, stepper motor 1 starts turning, and plunger pump airtight cavity becomes smaller, by connection hose 9, pressure sensor 10, connection
The pressure in pipeline that hose 11, sampling head bindiny mechanism 12, disposable sampling head 13 form generates variation.Initial stage pipeline
Pressure transient, crossbeam move along the Z direction, move to execution step a3 after S1 distance；
Step a3, the pressure value V1 of pressure sensor acquisition herein, executes step a4 later；
Step a4, crossbeam is moved to Z-direction simultaneously for piston pump motor movement, while acquiring pressure value V2 at regular intervals,
Step a5 is executed later；
Step a5, judge whether V2- V1 is greater than threshold value △ V, if it is a6 is thened follow the steps, if not, thening follow the steps a4；
Step a6, liquid level is detected, output detects liquid level signal, executes step a7 later；
Step a7, solenoid valve 5 is opened, stepper motor, which continues to run, drives plunger pump airtight cavity to bottom.It is then shut off electromagnetism
Valve 5.
Step a7, detecting liquid level terminates.
In conclusion described device includes for detecting the present invention provides a kind of liquid level sensor and detection method
The detecting liquid level mechanism of liquid level, the fluid path wiper mechanism for maintaining the gas in air cavity constant, for controlling detecting liquid level machine
The control system of structure and fluid path wiper mechanism, the detecting liquid level mechanism, the fluid path wiper mechanism are with the control respectively
System is connected.The method that the present invention carries out level detection by the analysis to pressure change in pipette, provides a structure letter
Single, stable, accuracy and reliability is high liquid level checking method and device, improves the sensitivity of level detection.
Claims (4)
1. the liquid detection device in a kind of active immunity work station, it is characterized in that: being equipped with plunger on sampling arm crossbeam
Pump, plunger pump are fixed with sampling arm crossbeam, and solenoid valve is connected with a connecting pin of plunger pump housing, is fixed by screws in
On plunger pump, sampling head bindiny mechanism is perpendicularly fixed at sampling arm crossbeam, sampling head bindiny mechanism and plunger pump and is connected by hose
It connects, there is pressure sensor to be connected in pipeline in the pipeline of connection.
2. the liquid detection device in a kind of active immunity work station as described in claim 1, it is characterized in that: solenoid valve is double
Port valve, wherein one end realizes the connection of plunger pump airtight cavity and solenoid valve by connection hose, and the other end passes through connection hose
With the connection of air.
3. the liquid detection device in a kind of active immunity work station as described in claim 1, it is characterized in that: pressure sensor
There are two connectors, are connected in plunger pump airtight cavity and sampling head bindiny mechanism, for the pressure in signal piping.
4. the liquid detection device in a kind of active immunity work station as described in claim 1, it is characterized in that: sampling head connects
Mechanism is conical tube.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810526143.4A CN108982893A (en) | 2018-05-29 | 2018-05-29 | A kind of liquid detection device in active immunity work station |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810526143.4A CN108982893A (en) | 2018-05-29 | 2018-05-29 | A kind of liquid detection device in active immunity work station |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108982893A true CN108982893A (en) | 2018-12-11 |
Family
ID=64542703
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810526143.4A Pending CN108982893A (en) | 2018-05-29 | 2018-05-29 | A kind of liquid detection device in active immunity work station |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108982893A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111458530A (en) * | 2020-05-12 | 2020-07-28 | 四川新健康成生物股份有限公司 | Dry-type immunoassay appearance application of sample device |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06109603A (en) * | 1992-09-25 | 1994-04-22 | Nippon Sekiyu Seisei Kk | Sampling device for liquid sample |
| JPH07103987A (en) * | 1993-10-04 | 1995-04-21 | Aloka Co Ltd | Method of detecting liquid level in automatic dispensing device |
| JP2004028968A (en) * | 2002-06-10 | 2004-01-29 | Toru Hiramatsu | Liquid dispenser |
| CN102221486A (en) * | 2011-06-03 | 2011-10-19 | 侯巍 | Sampling and liquid level detection device for automatic sampling system |
| CN106423324A (en) * | 2016-09-28 | 2017-02-22 | 长春迪瑞医疗科技股份有限公司 | Fluid transfer device and fluid transfer method |
| CN208206991U (en) * | 2018-05-29 | 2018-12-07 | 长春比特医疗仪器有限公司 | A kind of liquid detection device in active immunity work station |
-
2018
- 2018-05-29 CN CN201810526143.4A patent/CN108982893A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06109603A (en) * | 1992-09-25 | 1994-04-22 | Nippon Sekiyu Seisei Kk | Sampling device for liquid sample |
| JPH07103987A (en) * | 1993-10-04 | 1995-04-21 | Aloka Co Ltd | Method of detecting liquid level in automatic dispensing device |
| JP2004028968A (en) * | 2002-06-10 | 2004-01-29 | Toru Hiramatsu | Liquid dispenser |
| CN102221486A (en) * | 2011-06-03 | 2011-10-19 | 侯巍 | Sampling and liquid level detection device for automatic sampling system |
| CN106423324A (en) * | 2016-09-28 | 2017-02-22 | 长春迪瑞医疗科技股份有限公司 | Fluid transfer device and fluid transfer method |
| CN208206991U (en) * | 2018-05-29 | 2018-12-07 | 长春比特医疗仪器有限公司 | A kind of liquid detection device in active immunity work station |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111458530A (en) * | 2020-05-12 | 2020-07-28 | 四川新健康成生物股份有限公司 | Dry-type immunoassay appearance application of sample device |
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| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20181211 |