CN108969661A - A kind of new medicine cold compress agent and preparation method thereof - Google Patents

A kind of new medicine cold compress agent and preparation method thereof Download PDF

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CN108969661A
CN108969661A CN201810861215.0A CN201810861215A CN108969661A CN 108969661 A CN108969661 A CN 108969661A CN 201810861215 A CN201810861215 A CN 201810861215A CN 108969661 A CN108969661 A CN 108969661A
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rhizoma
radix
cold compress
compress agent
alcohol
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左良
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714Aconitum (monkshood)
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/65Amphibians, e.g. toads, frogs, salamanders or newts
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/11Pteridophyta or Filicophyta (ferns)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
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    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236Ligusticum (licorice-root)
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/237Notopterygium
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    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/238Saposhnikovia
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/26Aristolochiaceae (Birthwort family), e.g. heartleaf
    • A61K36/268Asarum (wild ginger)
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/54Lauraceae (Laurel family), e.g. cinnamon or sassafras
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/56Loganiaceae (Logania family), e.g. trumpetflower or pinkroot
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    • A61K36/18Magnoliophyta (angiosperms)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/716Clematis (leather flower)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/888Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8884Arisaema, e.g. Jack in the pulpit
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    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/898Orchidaceae (Orchid family)
    • A61K36/8988Gastrodia
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    • A61K2236/00Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH

Abstract

The present invention relates to a kind of new medicine cold compress agent and preparation method thereof, are prepared from the following raw materials: Radix Aconiti Kusnezoffii, Radix Aconiti, arisacma consanguineum schott, teasel root, rhizoma homalonemae, the root of Chinese clematis, asarum, Rhizoma Gastrodiae, radix saposhnikoviae, the rhizome of davallia, Radix Angelicae Pubescentis, cortex cinnamomi, Chinese prickly ash, Semen Strychni, Rhizoma Et Radix Notopterygii, lycopodium calvatum, corydalis tuber, Rhizoma Chuanxiong, toad skin, borneol, alcohol.The invention has the advantages that: rationally, therapeutic effect is strong for proportion, and production is simple, and replicability is strong, has significant curative effect for diseases such as scapulohumeral periarthritis, varication, prolapse of lumbar intervertebral disc.

Description

A kind of new medicine cold compress agent and preparation method thereof
Technical field
The present invention relates to technical field of traditional Chinese medicine preparation, in particular to a kind of new medicine cold compress agent and preparation method thereof.
Background technique
The diseases such as scapulohumeral periarthritis, varication, prolapse of lumbar intervertebral disc become the common disease of puzzlement mid-aged population, to the day of patient Often life brings inconvenience, and existing treatment method is mostly used the mode of physical therapy, and treatment results are not satisfactory, and usually multiple Hair, how to cure the diseases such as scapulohumeral periarthritis, varication, prolapse of lumbar intervertebral disc becomes the research topic of medical field.
Summary of the invention
The purpose of the present invention is to provide a kind of new medicine cold compress agent and preparation method thereof, to solve above-mentioned background technique The problem of middle proposition.
In order to solve the above technical problems, technical solution provided by the invention are as follows: a kind of new medicine cold compress agent, by following heavy The raw material of amount ratio is made:
1~10g of Radix Aconiti Kusnezoffii, 1~10g of Radix Aconiti, 1~7.5g of arisacma consanguineum schott, 1~7.5g of teasel root, 1~7.5g of rhizoma homalonemae, prestige 1~5g of medicine xiaolingxian, 1~7.5g of asarum, 1~7.5g of Rhizoma Gastrodiae, 1~5g of radix saposhnikoviae, 1~5g of the rhizome of davallia, 1~5g of Radix Angelicae Pubescentis, 1~5g of cortex cinnamomi, 1~7.5g of Chinese prickly ash, 1~10g of Semen Strychni, 1~7.5g of Rhizoma Et Radix Notopterygii, 1~7.5g of lycopodium calvatum, 1~5g of corydalis tuber, 1~7.5g of Rhizoma Chuanxiong, toad 20~30g of skin, 50~100g of borneol, alcohol 500g.
As a preferred embodiment, a kind of new medicine cold compress agent, is made of the raw material of following weight ratio: Radix Aconiti Kusnezoffii 2~ 8g, 2~8g of Radix Aconiti, 2~6g of arisacma consanguineum schott, 2~6g of teasel root, 2~6g of rhizoma homalonemae, 2~4g of the root of Chinese clematis, 2~6g of asarum, Rhizoma Gastrodiae 2 ~6g, 2~4g of radix saposhnikoviae, 2~4g of the rhizome of davallia, 2~4g of Radix Angelicae Pubescentis, 2~4g of cortex cinnamomi, 2~6g of Chinese prickly ash, 2~8g of Semen Strychni, Rhizoma Et Radix Notopterygii 2 ~6g, 2~6g of lycopodium calvatum, 2~4g of corydalis tuber, 2~6g of Rhizoma Chuanxiong, 22~28g of toad skin, 60~90g of borneol, alcohol 500g.
As a preferred embodiment, a kind of new medicine cold compress agent, it is characterised in that: the alcohol concentration is 75%.
A kind of production method of new medicine cold compress agent, is made by following steps:
1) in addition to borneol and alcohol, it will put in a drying box, adjust according to weight ratio after other raw materials removing impurity It is 40~45 DEG C of drying box temperature, 30 minutes dry;
2) borneol is put into the raw material after drying and is uniformly mixed, be ground into herb powder jointly;
3) herb powder is placed in alcohol, pours into soaking container jointly, do encapsulation process, be placed in 10~15 DEG C of cool places Place, rocked soaking container 15 minutes every 30 minutes, stood 3h after rocking three times;
4) soaking container after standing is opened, liquid in container is handled through 100 mesh filter screen filtrations, filtered fluid is Chinese medicine cold compress agent is poured into cold compress agent container and is sealed by Chinese medicine cold compress agent, 10~15 DEG C of chilling treatments.
Radix Aconiti Kusnezoffii: acrid flavour, hardship, property heat have analgesic, Wen Jing, wind-damp dispelling, anesthesia potency.
Radix Aconiti: acrid flavour, hardship, property heat have analgesic, Wen Jing, wind-damp dispelling, anesthesia potency.
Arisacma consanguineum schott: eliminating dampness and eliminating phlegm, expelling wind and relieving convulsion, mass dissipating and swelling eliminating are used for stupid productive cough, anemophlegmatic vertigo, heap soil or fertilizer over and around the roots of apoplexy phlegm, mouth eye Skew, hemiplegia, epilepsy, infantile convulsion, tetanus.
Teasel root: slightly warm in nature, it is bitter, pungent;Return liver and kidney channel.There is nourishing liver and kidney, strengthening the bones and muscles, continuous injured, stop the effect of metrorrhagia and metrostaxis, it can For treating the illnesss such as kidney deficiency and liver, soreness and weakness of waist and knees, rheumatic arthralgia, injury of tendon and muscle fracture, metrorrhagia and metrostaxis, vaginal bleeding during pregnancy, injury from falling down.
Rhizoma homalonemae: can wind-damp dispelling, strengthening the bones and muscles, for rheumatic arthralgia, the diseases such as soft, the brothers' muscular constricture paralysis of soreness of waist foot.
The root of Chinese clematis: nature and flavor are pungent, salty, warm, have the effect of dispelling wind and eliminating dampness, remove obstruction in channels to relieve pain, for treating rheumatic arthralgia, limbs Numbness, muscle arteries and veins contraction, joint stuffiness, bone are choked with sobs larynx.
Asarum: nature and flavor are pungent, warm, have the effect of expelling wind and clearing away cold, sensible analgesic, warming lung and resolving fluid, for treat anemofrigid cold, Headache, toothache, nasal obstruction nasosinusitis, rheumatic arthralgia, sputum cough.
Rhizoma Gastrodiae: dizziness pupil, cold and headache, extremity numbness, hemiplegia, aphasia, infantile epilepsy and convulsions are controlled.
Radix saposhnikoviae: be used for exogenous disease exterior syndrome, rubella itch, rheumatic arthralgia, tetanus just, the insufficiency of the spleen with overabundance of dampness.
The rhizome of davallia: The strong bone of kidney tonifying, continues and hinders pain relieving are used for lumbago due to the kidney deficiency, Hiccough and deaf, tooth mobility, falling winks frustrates, muscles and bones Injured;Control outward alopecia areata, leucoderma.
Radix Angelicae Pubescentis: being used for treating arthralgia due to cold and dampness, lumbocrural pain, few the moon volt wind headache, headache caused by cold and dampness.
Cortex cinnamomi: the Yang-function insufficiency of kidneyzang, cold weak pulse of limb are controlled in supplementing Yuanyang, warming spleen and stomach, removing internal cold, promoting blood circulation, and yang depletion is collapsed, and abdominal pain is let out It rushes down, cold hernia renal mass, waist and knee crymodynia, Jing Bi Disorder lump in the abdomen, negative subcutaneous ulcer, streamer, and empty sun is floating more, heat in the upper and cold in the lower.
Chinese prickly ash: acrid flavour heat enters returns spleen, stomach, kidney channel, has fragrant stomach invigorating, warming spleen and stomach for dispelling cold, damp dispelling and pain relieving, desinsection removing toxic substances, stops Itch and solves raw meat and other effects, the diseases such as primary treatment vomiting, wind-cold-dampness arthralgia, dentalgia.
Semen Strychni: cold in nature, bitter has the benefits of activating collaterals and eliminating stagnation, swelling and pain relieving.
Rhizoma Et Radix Notopterygii: exterior cold is dissipated;Wind-damp dispelling;Sharp joint;Analgesic.Main affection of exogenous wind-cold;It is headache and adiapneustia;Mimeograph cold-dampness numbness;Geomantic omen is floating It is swollen;Sore swollen toxin.
Lycopodium calvatum: nature and flavor are pungent, bitter, temperature, cold dispelling expelling pathogenic factors from muscles and skin, wind-dispelling dampness elimination, numbness relieving and pain relieving.
Corydalis tuber: nature and flavor are pungent, bitter, temperature.Enter liver, spleen, the heart channel of Hang-Shaoyin, effect is promoting blood circulation, sharp gas, analgesic.
Rhizoma Chuanxiong: being used for blood-activating and qi-promoting, and wind-expelling pain-stopping, Rhizoma Chuanxiong pungent-warm perfume (or spice) is dry, walks without keeping, and can go scattered, and uplink is up to mountain peak Top;Enter blood system again, downlink is up to the sea of blood.Promoting blood circulation effect is suitable for the various illnesss of stagnation of blood stasis extensively;Wind-expelling pain-stopping, effectiveness It is favourable, the diseases such as cold and headache, rheumatic arthralgia can be controlled.Former times people call Rhizoma Chuanxiong be blood in gas medicine, nearly say its reside it is pungent dissipate, relieve stagnation, it is sensible, The functions such as analgesic.
Toad skin: property is pungent, cool, and micro- poison can detoxify, reduces swelling, relieve pain.
Borneol: nature and flavor are arduous, cool, have and lead to all keys, dissipate stagnated fire, go the effect of screen improving eyesight, swelling and pain relieving, used in treating Air port keeps silent, pyreticosis coma, frightened epilepsy phlegm confusing heart, deafness with qi stagnation, sore throat, aphtha, tympanitis, carbuncle swells, hemorrhoid, mesh also screen film, enterobiasis Equal diseases.
The invention has the advantages that: rationally, therapeutic effect is strong for proportion, and production is simple, and replicability is strong, for scapulohumeral periarthritis, quiet The diseases such as arteries and veins varicose, prolapse of lumbar intervertebral disc have significant curative effect.
Specific embodiment
Illustrate the present invention with specific embodiment below, is not limitation of the present invention.
Embodiment 1
A kind of new medicine cold compress agent, is made of the raw material of following weight ratio: Radix Aconiti Kusnezoffii 2g, Radix Aconiti 2g, arisacma consanguineum schott 2g, Teasel root 2g, rhizoma homalonemae 2g, root of Chinese clematis 2g, asarum 2g, Rhizoma Gastrodiae 2g, radix saposhnikoviae 2g, rhizome of davallia 2g, Radix Angelicae Pubescentis 2g, cortex cinnamomi 2g, Chinese prickly ash 2g, Semen Strychni 2g, Rhizoma Et Radix Notopterygii 2g, lycopodium calvatum 2g, corydalis tuber 2g, Rhizoma Chuanxiong 2g, toad skin 22g, borneol 60g, 75% alcohol 500g.
A kind of production method of new medicine cold compress agent, is made by following steps:
1) in addition to borneol and alcohol, it will put in a drying box, adjust according to weight ratio after other raw materials removing impurity It is 40 DEG C of drying box temperature, 30 minutes dry;
2) borneol is put into the raw material after drying and is uniformly mixed, be ground into herb powder jointly;
3) herb powder is placed in alcohol, pours into soaking container jointly, do encapsulation process, be placed in 10 DEG C of shady places, often Soaking container is rocked 15 minutes every 30 minutes, stands 3h after rocking three times;
4) soaking container after standing is opened, liquid in container is handled through 100 mesh filter screen filtrations, filtered fluid is Chinese medicine cold compress agent is poured into cold compress agent container and is sealed by Chinese medicine cold compress agent, 10 DEG C of chilling treatments.
Embodiment 2
A kind of new medicine cold compress agent, is made of the raw material of following weight ratio: Radix Aconiti Kusnezoffii 3g, Radix Aconiti 2g, arisacma consanguineum schott 4g, Teasel root 4g, rhizoma homalonemae 4g, root of Chinese clematis 4g, asarum 4g, Rhizoma Gastrodiae 4g, radix saposhnikoviae 3g, rhizome of davallia 3g, Radix Angelicae Pubescentis 3g, cortex cinnamomi 3g, Chinese prickly ash 4g, Semen Strychni 3g, Rhizoma Et Radix Notopterygii 4g, lycopodium calvatum 4g, corydalis tuber 3g, Rhizoma Chuanxiong 4g, toad skin 25g, borneol 70g, 75% alcohol 500g.
A kind of production method of new medicine cold compress agent, is made by following steps:
1) in addition to borneol and alcohol, it will put in a drying box, adjust according to weight ratio after other raw materials removing impurity It is 42 DEG C of drying box temperature, 30 minutes dry;
2) borneol is put into the raw material after drying and is uniformly mixed, be ground into herb powder jointly;
3) herb powder is placed in alcohol, pours into soaking container jointly, do encapsulation process, be placed in 12 DEG C of shady places, often Soaking container is rocked 15 minutes every 30 minutes, stands 3h after rocking three times;
4) soaking container after standing is opened, liquid in container is handled through 100 mesh filter screen filtrations, filtered fluid is Chinese medicine cold compress agent is poured into cold compress agent container and is sealed by Chinese medicine cold compress agent, 12 DEG C of chilling treatments.
Embodiment 3
A kind of new medicine cold compress agent, is made of the raw material of following weight ratio: Radix Aconiti Kusnezoffii 4g, Radix Aconiti 6g, arisacma consanguineum schott 6g, Teasel root 6g, rhizoma homalonemae 6g, root of Chinese clematis 4g, asarum 6g, Rhizoma Gastrodiae 6g, radix saposhnikoviae 4g, rhizome of davallia 4g, Radix Angelicae Pubescentis 4g, cortex cinnamomi 4g, Chinese prickly ash 6g, Semen Strychni 4g, Rhizoma Et Radix Notopterygii 6g, lycopodium calvatum 6g, corydalis tuber 4g, Rhizoma Chuanxiong 6g, toad skin 28g, borneol 90g, 75% alcohol 500g.
A kind of production method of new medicine cold compress agent, is made by following steps:
1) in addition to borneol and alcohol, it will put in a drying box, adjust according to weight ratio after other raw materials removing impurity Drying box temperature 45 C, it is 30 minutes dry;
2) borneol is put into the raw material after drying and is uniformly mixed, be ground into herb powder jointly;
3) herb powder is placed in alcohol, pours into soaking container jointly, do encapsulation process, be placed in 15 DEG C of shady places, often Soaking container is rocked 15 minutes every 30 minutes, stands 3h after rocking three times;
4) soaking container after standing is opened, liquid in container is handled through 100 mesh filter screen filtrations, filtered fluid is Chinese medicine cold compress agent is poured into cold compress agent container and is sealed by Chinese medicine cold compress agent, 15 DEG C of chilling treatments.
A kind of application method of new medicine cold compress agent of the present invention: Chinese medicine cold compress agent is coated in body slight illness position, is rubbed Stranding is allowed to absorb, each primary in the morning, afternoon and evening.
Clinical data statistics:
Through clinical conditions scapulohumeral periarthritis patient totally 1020, the age is 840 of 55 years old or more, and the age is 40~55 years old 180.After use by 3 courses for the treatment of (course for the treatment of is one week), 982 to fully recover in 1020 patients are effectively slow 38 of solution, total effective rate is up to 100%.
Through clinical conditions varicose vein patients totally 530, the age is 380 of 55 years old or more, and the age is 40~55 150 of year.After use by 3 courses for the treatment of (course for the treatment of is one week), 512 to fully recover in 530 patients are effectively slow 18 of solution, total effective rate is up to 100%.
Through clinical conditions prolapse of lumbar intervertebral disc patient totally 840, the age is 720 of 55 years old or more, the age is 40~ 110 of 55 years old.After use by 3 courses for the treatment of (course for the treatment of is one week), 784 to fully recover in 840 patients, effectively 56 alleviated, total effective rate is up to 100%.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto, Anyone skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.

Claims (4)

1. a kind of new medicine cold compress agent, which is characterized in that be made of the raw material of following weight ratio:
1~10g of Radix Aconiti Kusnezoffii, 1~10g of Radix Aconiti, 1~7.5g of arisacma consanguineum schott, 1~7.5g of teasel root, 1~7.5g of rhizoma homalonemae, the root of Chinese clematis 1 ~5g, 1~7.5g of asarum, 1~7.5g of Rhizoma Gastrodiae, 1~5g of radix saposhnikoviae, 1~5g of the rhizome of davallia, 1~5g of Radix Angelicae Pubescentis, 1~5g of cortex cinnamomi, Chinese prickly ash 1 ~7.5g, 1~10g of Semen Strychni, 1~7.5g of Rhizoma Et Radix Notopterygii, 1~7.5g of lycopodium calvatum, 1~5g of corydalis tuber, 1~7.5g of Rhizoma Chuanxiong, toad skin 20 ~30g, 50~100g of borneol, alcohol 500g.
2. a kind of new medicine cold compress agent according to claim 1, which is characterized in that by the raw material system of following weight ratio At: 2~8g of Radix Aconiti Kusnezoffii, 2~8g of Radix Aconiti, 2~6g of arisacma consanguineum schott, 2~6g of teasel root, 2~6g of rhizoma homalonemae, 2~4g of the root of Chinese clematis, asarum 2~6g, 2~6g of Rhizoma Gastrodiae, 2~4g of radix saposhnikoviae, 2~4g of the rhizome of davallia, 2~4g of Radix Angelicae Pubescentis, 2~4g of cortex cinnamomi, 2~6g of Chinese prickly ash, Semen Strychni 2 ~8g, 2~6g of Rhizoma Et Radix Notopterygii, 2~6g of lycopodium calvatum, 2~4g of corydalis tuber, 2~6g of Rhizoma Chuanxiong, 22~28g of toad skin, 60~90g of borneol, alcohol 500g。
3. a kind of new medicine cold compress agent according to claim 1 or 2, it is characterised in that: the alcohol concentration is 75%.
4. a kind of production method of the described in any item new medicine cold compress agent of claim 1-3, which is characterized in that by walking as follows Suddenly it is made:
1) in addition to borneol and alcohol, it will be put in a drying box after other raw materials removing impurity according to weight ratio, adjust drying It is 40~45 DEG C of box temperature degree, 30 minutes dry;
2) borneol is put into the raw material after drying and is uniformly mixed, be ground into herb powder jointly;
3) herb powder is placed in alcohol, pours into soaking container jointly, do encapsulation process, be placed in 10~15 DEG C of shady places, often Soaking container is rocked 15 minutes every 30 minutes, stands 3h after rocking three times;
4) soaking container after standing is opened, liquid in container is handled through 100 mesh filter screen filtrations, filtered fluid is Chinese medicine Chinese medicine cold compress agent is poured into cold compress agent container and is sealed by cold compress agent, 10~15 DEG C of chilling treatments.
CN201810861215.0A 2018-08-01 2018-08-01 A kind of new medicine cold compress agent and preparation method thereof Pending CN108969661A (en)

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CN112023015A (en) * 2020-09-29 2020-12-04 江西中医药大学 Pain-relieving acupoint plaster and preparation method thereof
CN113144071A (en) * 2021-05-10 2021-07-23 张天睿 Fumigating traditional Chinese medicine composition and preparation method thereof

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CN112023015A (en) * 2020-09-29 2020-12-04 江西中医药大学 Pain-relieving acupoint plaster and preparation method thereof
CN112023015B (en) * 2020-09-29 2022-03-01 江西中医药大学 Pain-relieving acupoint plaster and preparation method thereof
CN113144071A (en) * 2021-05-10 2021-07-23 张天睿 Fumigating traditional Chinese medicine composition and preparation method thereof

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