CN1089597C

CN1089597C - Psoriasis treating Chinese medicine preparation and its preparing process

Info

Publication number: CN1089597C
Application number: CN98110138A
Authority: CN
Inventors: 王新岭
Original assignee: Individual
Current assignee: Individual
Priority date: 1998-04-01
Filing date: 1998-04-01
Publication date: 2002-08-28
Anticipated expiration: 2018-04-01
Also published as: CN1230420A

Abstract

The present invention discloses a Chinese medicine preparation for treating psoriasis, which is prepared from olibanum, myrrh (stir-frying with vinegar), calamus paste, centipede, lucid realgar and calculus bovis. The preparation of the present invention has the efficiency of activating blood circulation to dissipate blood stasis, tranquilizing to relieve muscle spasm, resisting bacteria and relieving inflammation. The preparation has the characteristics of improving microcirculatory and immunological regulation, inhibiting histocyte hyperplasy, strengthening the metabolism of the organism and eliminating the diseased tissues of psoriasis by the proper metabolic capability of the organism. The effective rate of the preparation reaches 100%, and the curative ratio reaches 91.67%.

Description

Psoriatic Chinese medicine preparation of a kind of treatment and preparation method thereof

The present invention relates to a kind of Chinese medicine preparation, the medicament of particularly a kind of treatment psoriasis (psoriasis).

Psoriasis is a kind of nonspecific inflammation pathological changes of aseptic, though the performance of its condition of illness at skin, right its morbidity basic reason; Think at present the dysfunction owing to the whole body multisystem, as immunologic dysfunction radical damage and spiritual maladjusted nervous system etc., be a kind of very painful refractory skin more, and the lighter pimple takes place, is taken off white scales, play is itched unbearably; The decortication of weight person's whole body, it is rotten to the corn to suppurate, LOM, at present, psoriasis is the clinical refractory disease that World Health Organization (WHO) generally acknowledges, its sickness rate is the trend that increases year by year in recent years, and is very big to patient's psychosomatic health harm.According to domestic statistics onset of psoriasis rate is 0.123 ‰, and wherein the patient more than 50% is the age less than 30 years old adolescence, and the child below 10 years old accounts for 15%.

Psoriasis is typing clinically: homeliness type, pustule type, arthritis type and erythroderma type are arranged, wherein see at most with homeliness type, patient is coated with argenteous multilamellar squama in the substrate of scytitis speckle, and clear border scrapes off the visible petechial hemorrhage of squama.Histopathology performance epithelial cells hyper-proliferative, parakeratosis.Therefore, in the custom treatment, use aminopterin, bimolane etc. usually, cytotoxic drug.Its curative effect is dissatisfied, and this type of medicine is failed to differentiate between the enemy and ourselves not guilty normal cell is murdered simultaneously.Only can mitigate the disease; In addition, the efficient corticosteroid hormone of the use that also has, as triamcinolone, the prolonged application psoriasis is not healed, and often causes other mortality complication again.The not specimen of taking stopgap measures, drug withdrawal soon, i.e. recurrence again, the treatment of recurrence back is difficulty more.In a word, still lack the psoriatic effective means of treatment at present both at home and abroad clinically.

The purpose of this invention is to provide the psoriatic Chinese medicine preparation of a kind of treatment, its curative effect highly significant, no side effects is difficult for recurrence.

Solution of the present invention is according to Chinese and western medicine research; psoriasis exists " blood stasis " to see the onset theory of disease; in conjunction with the whole immunomodulating pharmacology of Chinese medicine; the utilization activating blood and removing stasis drug; to Vascular Endothelial; can make vascular endothelial cell discharge PGI2 and t-PA,, regulate antiotasis and blood source state by these active substances.Prescription forms.By in clinical research, finding for many years, the external environment factor (cold, infection focus, neural psychic trauma, wound etc.) that causes onset of psoriasis, but equal different dermovascular function of influence or the blood vessel injury of degree, cause microcirculation disturbance, inflammation (immunity) reaction and histiocyte hypertrophy.Blood stasis is the main pathogenesis of this disease, and by six index observings of blood samples of patients rheology are shown: psoriatic microcirculation is because low shear rate increases and the erythrocyte electrophoretic time prolongation, thereby causes the erythrocyte aggregation ability to increase, and " blood stasis " witness has been described; The common pathophysiological basis of syndrome of blood stasis: be circulatory disturbance, inflammation (immunity) reaction and histiocyte hypertrophy.According to clinical practice and experimentation for many years, use with promoting blood circulation, promote that blood is capable, the dissipation blood stasis stimulates the menstrual flow, active, endogenous wind stopping relieving convulsion, suppressing the hyperactive liver and subsiding YANG.Dampness arresting convulsion Chinese medicine can fundamentally be adjusted the immunologic derangement state of psoriatic's complexity, suppresses too high humoral immunization, the immunologic function of enhancing cell; And can remove free radical, the medium that diminishes inflammation is with disease controlling, promotes the skin lesion healing.

The present invention is based on above-mentioned cognition, on the basis of more than ten years clinical experience, develop a kind ofly, the Chinese medicine preparation of significant curative effect is arranged psoriasis.

Contain Olibanum, Myrrha (processed with vinegar), Scolopendra, Realgar, Rhizoma Acori Graminei cream, Calculus Bovis medicament I of the present invention number.Contain for II number: Olibanum, Myrrha, Rhizoma Acori Graminei cream, Calculus Bovis.For alleviating side effect I number and II number every 5-7 days alternate application.

Formula optimization weight proportion scope of the present invention is:

I number: Olibanum (processed with vinegar) 8-45 part Scolopendra 2-10 part Myrrha (processed with vinegar) 8-45 part

Realgar 8-26 part Rhizoma Acori Graminei cream 1.5-8 part Calculus Bovis 0.2-0.8 part

II number: Olibanum (processed with vinegar) 8-45 part Rhizoma Acori Graminei cream 1.5-8 part

Myrrha (processed with vinegar) 8-45 part Calculus Bovis 0.2-0.8 part

The main effect of each composition is as follows among the we:

Olibanum, Myrrha (processed with vinegar): be dissipation blood stasis master's key medicine.It is capable stagnant that property and flavor of peppery and warm, suffering can be controlled blood, the warm blood vessels that can pass through; Olibanum is arrogated to oneself and is controlled blood, Myrrha (processed with vinegar) relatively these two kinds of medicines of clots absorbing often dual-purpose to strengthen the effect of its blood circulation promoting and blood stasis dispelling.And have the Tuoli to protect the heart, all poison of the cellulitis that disappears.

Scolopendra: cure mainly anxious chronic infantile convulsion, the tetanus apoplexy, it is strong to walk scurrying property, can extending from the interior to the exterior, it is outstanding especially to search the power that wind jerks surely, for suffer from, the main medicine of wind relieving convulsion also.

Rhizoma Acori Graminei: resuscitation inducing and mind tranquilizing, the water decoction that deoils, volatile oil or asarone, beta-Asarone all have sedation.Volatile oil has soporific function; Asaricin, volatile oil and decoct are all speeded slow smooth muscle spasm and are played the spasmolytic effect.The treatment of ulcer toxic swelling.

Realgar: counteracting toxic substances, dampness, parasite killing experiment in vitro prove that dermatophytes and antibacterial are had inhibitory action.

Calculus Bovis: heat-clearing and toxic substances removing, the endogenous wind stopping relieving convulsion, eliminate phlegm for resuscitation, have calm antibiotic effect, can suppress vascular permeability and antiinflammatory action is arranged.More than all medicines the effect of all poison of the cellulitis of disappearing is all arranged, this for psoriasis parakeratosis district try to gain sieve (munro) family name microabscess, and the spongy pimple of archaeology rank (kogi) family name of epidermis nipple top has effect.

The comprehensive drug of above-mentioned Chinese medicine and function are: blood circulation promoting and blood stasis dispelling, tranquillizing to relieve muscle spasm, anti-inflammation.

Medicaments preparation method of the present invention: can make the watered pill according to a conventional method.

Medicament of the present invention has the effect of blood circulation promoting and blood stasis dispelling, tranquillizing to relieve muscle spasm, anti-inflammation.Have microcirculation improvement and immunomodulating, suppress the histiocyte hypertrophy; Energy enhancing body metabolism is eliminated psoriasis by the metabolic capacity of body own and is become tissue.

Medicament of the present invention is by clinical experiment for over ten years, effective percentage 100%; Cure rate reaches more than 91.67%.

Describe below by embodiment and case.

Embodiment

I number: get Olibanum 25g, Myrrha (processed with vinegar) 25g, Rhizoma Acori Graminei cream 4g, Calculus Bovis 1g, Scolopendra 8g, Realgar 12g.

II number: get Olibanum 25g, Myrrha (processed with vinegar) 25g, Rhizoma Acori Graminei cream 9g, Calculus Bovis 1g.

The medicine of above-mentioned prescription was pulverized 100 mesh sieves respectively and was become fine powder after concocting, except that the Realgar yellow fluid flew, other drug mixed, and makes substrate with the Semen setariae meal, I 22.5g, and II 153g is a ball, Semen phaseoli radiati is big.

This oral drug:

I day is obeyed secondary, and one time 3-6g serve on 7 days, and stop using then to change for I number and take II number, day clothes 2 times, one time 3-6g serve on 7 days.14 is a course of treatment; It is invalid that observation skin lesion no change person one course of treatment is decided to be, and the responder more continues treatment, and the longest is 3 courses of treatment.Avoid Carnis caprae seu ovis, anemia of pregnant woman's forbidding.

Case observation:

1, clinical data:

In June, 1989 to 1997 year December complete data person 60 examples.The overwhelming majority is the homeliness type patient.Man's 36 examples, women 24 examples, the age 14 was to 59 years old; Course of disease February to 30 year, person's 38 examples (accounting for 63.3%) person's 12 examples (accounting for 20%) more than 15 years more than 1 year.

2, efficacy determination and result:

Recovery from illness is all disappeared for skin lesion; Produce effects is that skin lesion disappears more than 70%; Effectively for skin lesion disappears more than 30%, invalid do not have improvement for treating the front and back skin lesion.

The result: 55 examples of fully recovering (91.67%), produce effects 5 examples (8.33%), total effective rate is 100%.3 to 7 take effect after the general medication; The course of disease year patient's curative effect in February to 1 is excellent, and particularly drop shape erythra patient is particularly remarkable.Skin lesion all disappeared in 15 to 20 days, elder 42 days.Have a routine urine test after the treatment, the platelet numeration, it is all normal to go out clotting time and liver function.

3, medicament side effect:

After the patient takes medicine, have indivedual cases to have gargalesthesia, drug withdrawal continued treatment behind the transference cure in 3 to 5 days; There are 2 routine patients really to belong to have play to itch or erythra occurs, stop using I number behind the transference cure; Take II number separately until recovery from illness.

Claims

1, the psoriatic Chinese medicine preparation of a kind of treatment, form by I number, II medicine, it is characterized in that the I medicine is made by following proportion raw material: Olibanum 8-45 part, Myrrha 8-45 part, Rhizoma Acori Graminei cream 1.5-8 part, Scolopendra 2-10 part, Realgar 8-26 part, Calculus Bovis 0.2-8 part; The II medicine is made by following proportioning raw material: Olibanum 8-45 part, Myrrha 8-45 part, Rhizoma Acori Graminei cream 1.5-8 part, Scolopendra 2-10 part, Calculus Bovis 0.2-8 part.

2, the preparation method of Chinese medicine preparation according to claim 1 is characterized in that:

(1) select raw material: I number by following proportioning: 25 parts of Olibanums, 25 parts of Myrrhas, 4 parts of Rhizoma Acori Graminei cream, 8 parts of Scolopendras, 20 parts of Realgars, 1 part of Calculus Bovis: II number: 25 parts of Olibanums, 25 parts of Myrrhas, 8 parts of Rhizoma Acori Graminei cream, 8 parts of Scolopendras, 1 part of Calculus Bovis,

(2) with the raw material of above-mentioned prescription, each pulverized 100 mesh sieve fine powders after concocting, the mixing sterilization, and except that the Realgar yellow fluid flew, other drug mixed, and makes substrate with the Semen setariae meal, I number 22.5 grams, II number 153 grams are ball, Semen phaseoli radiati is big.