CN108955990B - Experimental device for radial holding power of vascular support in real-time supervision simulation environment - Google Patents
Experimental device for radial holding power of vascular support in real-time supervision simulation environment Download PDFInfo
- Publication number
- CN108955990B CN108955990B CN201810787140.6A CN201810787140A CN108955990B CN 108955990 B CN108955990 B CN 108955990B CN 201810787140 A CN201810787140 A CN 201810787140A CN 108955990 B CN108955990 B CN 108955990B
- Authority
- CN
- China
- Prior art keywords
- stent
- elastic tube
- polymer transparent
- transparent elastic
- supporting force
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01L—MEASURING FORCE, STRESS, TORQUE, WORK, MECHANICAL POWER, MECHANICAL EFFICIENCY, OR FLUID PRESSURE
- G01L9/00—Measuring steady of quasi-steady pressure of fluid or fluent solid material by electric or magnetic pressure-sensitive elements; Transmitting or indicating the displacement of mechanical pressure-sensitive elements, used to measure the steady or quasi-steady pressure of a fluid or fluent solid material, by electric or magnetic means
- G01L9/02—Measuring steady of quasi-steady pressure of fluid or fluent solid material by electric or magnetic pressure-sensitive elements; Transmitting or indicating the displacement of mechanical pressure-sensitive elements, used to measure the steady or quasi-steady pressure of a fluid or fluent solid material, by electric or magnetic means by making use of variations in ohmic resistance, e.g. of potentiometers, electric circuits therefor, e.g. bridges, amplifiers or signal conditioning
- G01L9/04—Measuring steady of quasi-steady pressure of fluid or fluent solid material by electric or magnetic pressure-sensitive elements; Transmitting or indicating the displacement of mechanical pressure-sensitive elements, used to measure the steady or quasi-steady pressure of a fluid or fluent solid material, by electric or magnetic means by making use of variations in ohmic resistance, e.g. of potentiometers, electric circuits therefor, e.g. bridges, amplifiers or signal conditioning of resistance-strain gauges
Landscapes
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Media Introduction/Drainage Providing Device (AREA)
Abstract
The invention discloses an experimental device for monitoring and simulating the radial supporting force of a vascular stent in a blood vessel in real time, which comprises a speed-adjustable peristaltic pump (1), a liquid storage tank (2), a water bath tank (3), a stent average radial supporting force monitoring device (4) and a silica gel hose (5) connecting all parts, wherein the stent average radial supporting force monitoring device (4) comprises a vascular stent (6), an inner-layer polymer transparent elastic tube (7), a resistance strain wire type sensor (8), an outer-layer polymer transparent elastic tube (9), a polymer transparent rigid tube (10), a fixed sleeve (11), a data collector (12) and a computer (13); the device can monitor the radial supporting force of the intravascular stent on the simulated blood vessel in the in-vitro flowing corrosive medium in real time. The experimental device can measure the average radial supporting force of the intravascular stent with different materials and structures, and has the advantages of simple structure, low cost and convenient operation.
Description
Technical Field
The invention relates to an experimental device for monitoring the radial supporting force of a vascular stent in a simulated environment in real time, and belongs to the field of mechanical property testing of medical instruments.
Background
The radial mechanical property of the vascular stent is mainly reflected in the resistance of the vascular stent to external pressure and the strain capacity of the vascular stent to external force, and the characteristic determines whether the vascular stent can be closely attached to a vascular wall. The supporting force is too small, the tube cavity of the vascular stent becomes small under the reaction force of the blood vessel, vascular embolism is easily caused, the medical effect of the vascular stent cannot be exerted, and the vascular stent is easily displaced under the effect of blood flow; and the too large supporting force can cause local vessel wall damage (such as perforation, tearing, rupture and the like), cause excessive repair reaction of surrounding tissues, and cause intimal hyperplasia and the like. Therefore, the average radial supporting capacity of the blood vessel stent is an important performance index for evaluating the design structure of the blood vessel stent.
The vascular stent can receive the influence of blood flow and blood vessel pulsation during the human body is in service, and various physiological activities of human body can also produce the effect of power to vascular stent simultaneously, cause the decay of the radial mechanical properties of support, make it lose the supporting role to the vascular wall, cause the restenosis of blood vessel. For the balloon expandable stent, when the pressure born by the balloon expandable stent from the outside reaches the critical value, the vascular stent has permanent defects of collapse, instability, deformation and the like, so that the supporting force and rigidity of the vascular stent are reduced, and the balloon expandable stent is particularly serious for the degradable vascular stent which can bear the maximum radial pressure and continuously reduce along with the degradation of the stent; for the self-expanding blood vessel stent, permanent deformation generally does not occur due to high elasticity, good temperature memory effect and radial flexibility, but buckling deformation occurs under certain action conditions, and although the self-expanding blood vessel stent can recover to the original shape after stress release, the process still causes harm to a patient.
In the pharmaceutical industry standard YY/T0663.2-2016, four definitions are involved with respect to the radial mechanical properties of vascular stents: radial anti-extrusion performance, parallel plate anti-extrusion performance, local extrusion performance and radial supporting force. The radial anti-extrusion performance is the capability of the balloon expandable stent to resist permanent deformation under the action of radial loads uniformly distributed along the circumference; parallel plate crush resistance is the ability of a stent to resist permanent deformation when subjected to a load that is evenly distributed along the length of the overall stent; local crush performance is the ability of a stent to resist permanent deformation when subjected to a local load (e.g., a point load); radial support force is the force that the self-expanding stent exerts on the vessel wall during the release phase.
Because the vascular stent has various types and different parts suitable for pathological changes, and the national standard and the industrial standard only give out guiding principles and have no specific experimental method and technical parameter requirements, the testing method and the technical index of the radial mechanical property of the vascular stent have no uniform standard. The currently used specific experimental methods for radial mechanical properties mainly include three types: the test method comprises the following steps of anti-parallel plate extrusion performance test, V-shaped groove extrusion performance test, radial anti-extrusion performance test and radial anti-hydraulic pressure test. The accuracy of the parallel plate extrusion resistance test and the V-shaped groove extrusion resistance test is higher, but the stress mode of the stent is different from the actual action mode in the blood vessel environment, so that the radial strength of the stent can only be indirectly reflected; the radial anti-extrusion performance test simulates the actual radial stress condition of the stent in the blood vessel, and the chronic abduction force of the stent on the blood vessel can be simultaneously obtained while the radial compression force of the blood vessel on the stent is obtained; the radial hydraulic resistance test can also better simulate the stress form of the stent in the blood vessel, but the precision is lower and the uncertain factors are more.
Aiming at the experimental research of key indexes of the radial mechanical property of the vascular stent, a simple, applicable and effective average radial supporting force testing method is needed, a device which can accurately monitor the average radial supporting force of the vascular stent on a simulated blood vessel in an in-vitro simulated blood fluid in real time can be used, the mechanical properties of the vascular stent of different materials and structures can be inspected, and a scientific theoretical basis is provided for establishing and perfecting a detection and evaluation system of the radial mechanical property of the vascular stent.
Disclosure of Invention
The technical problem is as follows: the invention aims to design an experimental device for monitoring the radial supporting force of a vascular stent in a simulated environment in real time, the device can truly simulate the service behavior of the vascular stent in a blood vessel, can monitor the average radial supporting force of the stent on the simulated blood vessel in real time, is controllable in flow rate, experimental temperature and corrosion medium of a flow field, and is suitable for vascular stent test pieces of different materials, sizes and structures.
The technical scheme is as follows: the invention provides an experimental device for monitoring and simulating the radial supporting force of a vascular stent in a blood vessel in real time, which comprises a speed-adjustable peristaltic pump, a liquid storage tank, a water bath tank, a stent average radial supporting force monitoring device and a silica gel hose connected among all the parts, wherein the silica gel hose penetrates through the interior of the speed-adjustable peristaltic pump, one end of the silica gel hose is connected with the liquid storage tank, the other end of the silica gel hose is connected with the stent average radial supporting force monitoring device, and the liquid storage tank and the stent average radial supporting force monitoring device are connected together through another silica gel hose to form a circulating corrosive medium flow field environment;
the liquid storage tank is arranged in the water bath tank;
the average radial supporting force monitoring device of the stent comprises a vascular stent, an inner polymer transparent elastic tube, a resistance strain wire type sensor, an outer polymer transparent elastic tube, a polymer transparent rigid tube, a fixing sleeve, a data collector and a computer, wherein the vascular stent is arranged in the inner polymer transparent elastic tube, the resistance strain wire type sensor is wound on the outer surface of the inner polymer transparent elastic tube, the outer polymer transparent elastic tube is attached outside a resistance strain wire type sensor coil, the resistance strain wire type sensor is wrapped between the inner polymer transparent elastic tube and the outer polymer transparent elastic tube, the outer polymer transparent elastic tube is arranged in the polymer transparent rigid tube through the fixing sleeve, and the data collector is connected with the resistance strain wire type sensor and is connected with the computer.
Wherein:
the adjustable-speed peristaltic pump is used for controlling the flow speed and the flow of a corrosive medium in the experimental device, the liquid storage tank is used for replacing the corrosive medium in the experimental device, and the temperature of the water bath tank is adjustable and used for adjusting the temperature of the corrosive medium in the experimental device.
The inner layer polymer transparent elastic tube and the outer layer polymer transparent elastic tube are simulated vessel walls, the wall thicknesses of the inner layer polymer transparent elastic tube and the outer layer polymer transparent elastic tube are both 0.1-0.5 mm, and the inner layer polymer transparent elastic tube and the outer layer polymer transparent elastic tube are made of Polyurethane (PU), terylene or expanded polytetrafluoroethylene.
The wall thickness of the polymer transparent rigid pipe is 1 mm-5 mm, and the material is PMMA (polymethyl methacrylate), PP (polypropylene), PVC (polyvinyl chloride), PC (polycarbonate) or ABS (polyacrylonitrile).
The outer surface of the inner polymer transparent elastic tube is wound with the resistance strain wire type sensor, namely the resistance strain wire is uniformly and annularly wound on the outer surface of the inner polymer transparent elastic tube, the thread pitch is 0.03-0.5 mm, the resistance strain wire is enabled to cover the outer surface of the area, covered with the vascular stent, of the inner polymer transparent elastic tube in a coil shape, the average radial supporting force of the area, where the vascular stent exists, is measured, the average contact pressure data among the vascular stent, the simulated vascular wall formed by the inner polymer transparent elastic tube and the outer polymer transparent elastic tube is displayed in real time through corresponding software, the average radial pressure value of the area, where the vascular stent is located, is obtained, and data analysis is carried out.
The coil material of the resistance strain wire type sensor is an alloy wire or a semiconductor wire, the diameter of the alloy wire is 0.015-0.05 mm, the sensitivity coefficient of the alloy wire is 2-6, and the sensitivity coefficient of the semiconductor wire is more than 150.
The alloy wire or the semiconductor wire is one of copper-nickel alloy, iron-chromium-aluminum alloy, nickel-chromium-iron alloy, platinum or platinum alloy.
The device for monitoring the average radial supporting force of the stent is used for monitoring the average radial supporting force of the intravascular stent in a simulated blood vessel in the experimental process or the average radial compressive force of the stent in the simulated blood vessel, and the force measuring range is 0.0006-170 MPa.
The device for monitoring the average radial supporting force of the stent is suitable for real-time measurement of intravascular stents of different sizes, materials and structures.
The mutual contact surfaces among the inner layer polymer transparent elastic tube, the resistance strain wire type sensor, the outer layer polymer transparent elastic tube and the polymer transparent rigid tube are smooth and flat, and the joint has no relative sliding.
The intravascular stent contacts the inner layer polymer transparent elastic tube along the circumferential direction and directly acts on the resistance strain wire type sensor coated in the inner layer elastic tube and the outer layer elastic tube, the radial force exerted on the intravascular stent is uniformly distributed, and the force value exerted on the sensor coil is acquired through the resistance value change of the sensor.
Has the advantages that: compared with the prior art, the invention has the following beneficial effects:
1) the experimental device provided by the invention can truly simulate the actual average stress condition of the blood vessel stent in the blood vessel. Different from the common parallel plate extrusion performance test experiment, the device measures the data to be the radial load action uniformly distributed along the circumference of the stent, more truly reflects the stress situation of the vascular stent in the human blood vessel, and can simultaneously obtain the chronic abduction force of the stent on the blood vessel while obtaining the radial compression force of the blood vessel on the stent. In addition to the blood vessels of the human body, which are capillaries and lymphatic capillaries, the walls of blood vessels can be roughly divided into three layers: the intima, media and adventitia, which are composed of endothelial cells, smooth muscle cells and connective tissue, respectively, are mainly mechanically supported by the smooth muscle cell layer, so that an elastic material, such as polyurethane, is selected as a simulated vessel wall to achieve mechanical properties matching those of a blood vessel, and the polyurethane material has a microphase separation structure very similar to that of the inner wall of a blood vessel of a living body: macroscopically, the surface is very smooth, microscopically, the surface is a double-layer lipid liquid matrix layer, and various glycoproteins and glycolipids are embedded in the middle; artificial blood vessels made of other materials such as polyester, expanded polytetrafluoroethylene (ePTFE), and other polymer materials have also reached practical levels. Meanwhile, the flow field environment generated by the device can truly simulate the flow of blood, and the speed, flow and temperature of the flow field can be controlled.
2) The experimental device provided by the invention can accurately monitor the average radial supporting force of the blood vessel stent acting part on the simulated blood vessel in real time. Compared with the static radial mechanical property test of the vascular stent, the device can obtain the real-time average radial supporting force data of the vascular stent in the simulated vascular service process, and obtain the dynamic data of the average radial supporting force changing along with the time extension of an in vitro simulation experiment through software, so that the change of the radial supporting force of the vascular stent in the vascular service process can be evaluated more intuitively and scientifically.
3) The experimental device provided by the invention is simple, low in cost and wide in application range, can be used for measuring the radial supporting force of the vascular stents with different sizes, materials and structures in real time, and has universal applicability, and the experimental temperature, the flow field flow and the corrosive medium can be adjusted.
Drawings
FIG. 1 is a schematic diagram of an experimental apparatus for real-time monitoring and simulating the radial supporting force of a vascular stent in a blood vessel;
FIG. 2 is a schematic view of a stent average radial support force monitoring device;
the figure shows that: the device comprises a speed-adjustable peristaltic pump 1, a liquid storage tank 2, a water bath tank 3, a support average radial supporting force monitoring device 4, a silica gel hose 5, a blood vessel support 6, an inner layer polymer transparent elastic tube 7, a resistance strain wire type sensor 8, an outer layer polymer transparent elastic tube 9, a polymer transparent rigid tube 10, a fixed sleeve 11, a data acquisition unit 12 and a computer 13.
Detailed Description
The invention provides a device capable of accurately monitoring the average radial supporting force of a vascular stent on a simulated blood vessel in an in-vitro simulated blood fluid environment in real time, which is suitable for measuring the average radial supporting force of the vascular stent on the simulated blood vessel wall in a flowing corrosive medium in real time, and the invention is further described with reference to the attached drawings.
As shown in fig. 1, an experimental device for monitoring and simulating the radial supporting force of a vascular stent in a blood vessel in real time comprises a speed-adjustable peristaltic pump 1, a liquid storage tank 2, a water bath tank 3, a stent average radial supporting force monitoring device 4 and a silica gel hose 5 connecting all the components, wherein the silica gel hose 5 penetrates through the inside of the speed-adjustable peristaltic pump 1, one end of the silica gel hose 5 is connected with the liquid storage tank 2, the other end of the silica gel hose 5 is connected with the stent average radial supporting force monitoring device 4, and the liquid storage tank 2 and the stent average radial supporting force monitoring device 4 are connected together through another silica gel hose 5 to form a circulating corrosive medium flow field environment; the liquid storage tank 2 is arranged in the water bath tank 3;
the adjustable-speed peristaltic pump 1 controls the flow speed and flow of a corrosive medium in the experimental device, the liquid storage tank 2 replaces the corrosive medium in the experimental device, and the water bath tank 3 is adjustable in temperature and used for adjusting the temperature of the corrosive medium in the experimental device;
as shown in fig. 2, the device 4 for monitoring average radial supporting force of a stent comprises a blood vessel stent 6, an inner polymer transparent elastic tube 7, a resistance strain wire type sensor 8, an outer polymer transparent elastic tube 9, a polymer transparent rigid tube 10, a fixing sleeve 11, a data collector 12 and a computer 13, wherein the blood vessel stent 6 is installed in the inner polymer transparent elastic tube 7, the resistance strain wire type sensor 8 is wound on the outer surface of the inner polymer transparent elastic tube 7, the outer polymer transparent elastic tube 9 is attached to the outside of the coil of the resistance strain wire type sensor 8, the resistance strain wire type sensor 8 is wrapped between the inner polymer transparent elastic tube 7 and the outer polymer transparent elastic tube 9, the outer polymer transparent elastic tube 9 is installed in the polymer transparent rigid tube 10 through the fixing sleeve 11, the data collector 12 is connected with the resistance strain wire type sensor 8, and is connected with a computer 13;
the wall thicknesses of the inner polymer transparent elastic tube 7 and the outer polymer transparent elastic tube 9 are 0.05-0.5 mm, and the used materials are polymer materials with mechanical properties similar to those of the vessel wall, such as Polyurethane (PU), terylene, expanded polytetrafluoroethylene (ePTFE) and the like; the wall thickness of the polymer rigid pipe 10 is 1 mm-5 mm, and the used materials are polymer materials with better mechanical stability and corrosion resistance, such as polymethyl methacrylate (PMMA), polypropylene (PP), polyvinyl chloride (PVC), Polycarbonate (PC), polyacrylonitrile (ABS) and the like.
The outer surface of the inner polymer transparent elastic tube 7 is wound with the resistance strain wire type sensor 8, namely resistance strain wires are uniformly and annularly wound on the outer surface of the inner polymer transparent elastic tube 7, the thread pitch is 0.03-0.5 mm, the resistance strain wires are covered on the outer surface of the area where the inner polymer transparent elastic tube 7 is coated with the vascular stent 8 in a coil shape, the average radial supporting force of the area where the vascular stent 8 exists is measured, the average contact pressure data of a simulated vascular wall formed by the vascular stent, the inner polymer transparent elastic tube 7 and the outer polymer transparent elastic tube 9 is displayed in real time through corresponding software, the average radial pressure value of the area where the vascular stent is located is obtained, and data analysis is carried out.
The coil material of the resistance strain wire type sensor 8 is an alloy wire or a semiconductor wire, the diameter of the coil material is 0.015-0.05 mm, the sensitivity coefficient of the alloy wire is 2-6, and the sensitivity coefficient of the semiconductor wire is more than 150.
The alloy wire or the semiconductor wire is made of copper-nickel alloy, iron-chromium-aluminum alloy, nickel-chromium-iron alloy, platinum or platinum alloy and the like.
The device 4 for monitoring the average radial supporting force of the stent is used for monitoring the average radial supporting force of the intravascular stent 6 in a simulated blood vessel in the experimental process or the average radial compressive force of the stent in the simulated blood vessel, the force measuring range is 0.0006-170 MPa, and the device is suitable for real-time measurement of intravascular stents 6 with different sizes, materials and structures.
The mutual contact surfaces among the inner polymer transparent elastic tube 7, the resistance strain wire type sensor 8, the outer polymer transparent elastic tube 9 and the polymer transparent rigid tube 10 are smooth and flat, and the joint has no relative sliding.
The intravascular stent 6 contacts the inner-layer polymer transparent elastic tube 7 along the circumferential direction and directly acts on the resistance strain wire type sensor 8 coated in the inner-layer elastic tube and the outer-layer elastic tube, the radial force exerted on the intravascular stent 6 is uniformly distributed, and the force value acted on the sensor coil is acquired through the resistance value change of the sensor.
Example 1
As shown in the device of fig. 2, the blood vessel stent 6 selected for testing is a WE43 magnesium alloy balloon-expandable degradable blood vessel stent formed by weaving, the stent which is pressed tightly is preloaded on a balloon catheter and is delivered into an inner PU transparent elastic tube 7, the balloon is filled by a filling pressure pump to reach nominal pressure, the bracket extrudes the inner PU transparent elastic tube 7, the nichrome resistance strain wire coil 8 and the outer PU transparent elastic tube 9 outwards, simultaneously, the stent is expanded, the saccule at the far end of the catheter is withdrawn after decompression and contraction, the adopted corrosive medium is a simulated plasma solution, the temperature is 37 ℃, the flow field speed is controlled by the speed-adjustable peristaltic pump 1, in corrosive medium fluid, the radial supporting force of the magnesium alloy bracket is continuously reduced along with the degradation of the magnesium alloy bracket, the method can record the attenuation of the average radial supporting force of the bracket along with the degradation process in real time, and provides scientific basis for the research on the degradation influence of the load on the degradable magnesium alloy bracket.
Example 2
The device is the same as the embodiment 1, the selected blood vessel support 6 for testing is a nickel-titanium shape memory alloy self-expanding blood vessel support formed by laser engraving, the support is preloaded on a conveying conduit and placed in a PU transparent elastic tube 7 and connected to a blood circulation simulating device through a silica gel hose 5, the adopted corrosive medium is simulated plasma, the flow field flow rate is controlled through a speed-adjustable peristaltic pump 1, the temperature is adjusted to 37 ℃, the alloy transition temperature is reached, the support gradually deforms and expands and generates supporting force on the elastic tube, constantan wires are selected as metal resistance strain wires, the average radial supporting force change in the expansion process and the retraction process of the support is recorded in real time, and the influence of blood flow on the radial supporting force of the blood vessel support is researched.
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention are described below clearly and completely, and it is obvious that the described embodiments are a part of the embodiments of the present invention, not all of the embodiments of the present invention. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without any creative work belong to the protection scope of the present invention.
Claims (6)
1. The utility model provides an experimental apparatus of intravascular stent radial support power in real-time supervision simulated environment which characterized in that: the device comprises a speed-adjustable peristaltic pump (1), a liquid storage tank (2), a water bath tank (3), a support average radial supporting force monitoring device (4) and a silica gel hose (5) for connecting all the components, wherein the silica gel hose (5) penetrates through the inside of the speed-adjustable peristaltic pump (1), one end of the silica gel hose is connected with the liquid storage tank (2), the other end of the silica gel hose is connected with the support average radial supporting force monitoring device (4), and the liquid storage tank (2) and the support average radial supporting force monitoring device (4) are connected together through another silica gel hose (5) to form a circulating corrosive medium flow field environment;
the liquid storage tank (2) is arranged in the water bath tank (3);
the average radial support force monitoring device (4) of the stent comprises a blood vessel stent (6), an inner polymer transparent elastic tube (7), a resistance strain wire type sensor (8), an outer polymer transparent elastic tube (9), a polymer transparent rigid tube (10), a fixing sleeve (11), a data collector (12) and a computer (13), wherein the blood vessel stent (6) is installed in the inner polymer transparent elastic tube (7), the resistance strain wire type sensor (8) is wound on the outer surface of the inner polymer transparent elastic tube (7), the outer polymer transparent elastic tube (9) is attached outside a coil of the resistance strain wire type sensor (8), the resistance strain wire type sensor (8) is wrapped between the inner polymer transparent elastic tube (7) and the outer polymer transparent elastic tube (9), the outer polymer transparent elastic tube (9) is installed in the polymer transparent rigid tube (10) through the fixing sleeve (11), the data acquisition unit (12) is connected with the resistance strain wire type sensor (8) and is connected with the computer (13);
the inner layer polymer transparent elastic tube (7) and the outer layer polymer transparent elastic tube (9) are simulated vessel walls, the wall thicknesses of the inner layer polymer transparent elastic tube (7) and the outer layer polymer transparent elastic tube (9) are both 0.1-0.5 mm, and the inner layer polymer transparent elastic tube and the outer layer polymer transparent elastic tube are made of Polyurethane (PU), terylene or expanded polytetrafluoroethylene;
the outer surface of the inner polymer transparent elastic tube (7) is wound with a resistance strain wire type sensor (8), namely resistance strain wires are uniformly and annularly wound on the outer surface of the inner polymer transparent elastic tube (7), the thread pitch is 0.03-0.5 mm, the resistance strain wires are covered on the outer surface of the area, coated with the vascular stent (8), of the inner polymer transparent elastic tube (7) in a coil shape, and the average radial supporting force of the area, where the vascular stent (8) exists, is measured;
the coil material of the resistance strain wire type sensor (8) is an alloy wire or a semiconductor wire, the diameter of the coil material is 0.015-0.05 mm, the sensitivity coefficient of the alloy wire is 2-6, and the sensitivity coefficient of the semiconductor wire is more than 150.
2. The experimental device for monitoring the radial supporting force of the blood vessel stent in the simulated environment in real time as claimed in claim 1, wherein: the wall thickness of the polymer transparent rigid pipe (10) is 1-5 mm, and the material is PMMA (polymethyl methacrylate), PP (polypropylene), PVC (polyvinyl chloride), PC (polycarbonate) or ABS (polyacrylonitrile).
3. The experimental device for monitoring the radial supporting force of the blood vessel stent in the simulated environment in real time as claimed in claim 1, wherein: the alloy wire or the semiconductor wire is one of copper-nickel alloy, iron-chromium-aluminum alloy, nickel-chromium-iron alloy, platinum or platinum alloy.
4. The experimental device for monitoring the radial supporting force of the blood vessel stent in the simulated environment in real time as claimed in claim 1, wherein: the device for monitoring the average radial supporting force of the stent (4) is used for monitoring the average radial supporting force of the vascular stent (6) in the simulated blood vessel in the experimental process or the average radial compressive force of the stent in the simulated blood vessel, and the force measuring range is 0.0006-170 MPa.
5. The experimental device for monitoring the radial supporting force of the blood vessel stent in the simulated environment in real time as claimed in claim 1, wherein: the mutual contact surfaces among the inner layer polymer transparent elastic tube (7), the resistance strain wire type sensor (8), the outer layer polymer transparent elastic tube (9) and the polymer transparent rigid tube (10) are smooth and flat, and the joint has no relative sliding.
6. The experimental device for monitoring the radial supporting force of the blood vessel stent in the simulated environment in real time as claimed in claim 1, wherein: the temperature of the water bath tank (3) can be adjusted.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2018103521723 | 2018-04-19 | ||
| CN201810352172 | 2018-04-19 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN108955990A CN108955990A (en) | 2018-12-07 |
| CN108955990B true CN108955990B (en) | 2020-12-11 |
Family
ID=64481577
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810787140.6A Active CN108955990B (en) | 2018-04-19 | 2018-07-16 | Experimental device for radial holding power of vascular support in real-time supervision simulation environment |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108955990B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114452033B (en) * | 2022-04-13 | 2022-07-01 | 深圳市库珀科技发展有限公司 | Ureteral stent and test device thereof |
| CN115672431B (en) * | 2022-10-18 | 2023-06-13 | 哈尔滨工业大学（威海） | Extracorporeal circulation and lumen intervention isolated blood vessel constant temperature auxiliary device |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1839300A (en) * | 2003-08-20 | 2006-09-27 | 株式会社山武 | Pressure sensor device |
| WO2010022173A1 (en) * | 2008-08-19 | 2010-02-25 | Tissuegen, Inc. | Self-expanding medical device |
| CN102568720A (en) * | 2011-12-19 | 2012-07-11 | 北京东方计量测试研究所 | Tension constant resistor capable of calculating difference of alternating current and direct current |
| CN106821305A (en) * | 2017-03-23 | 2017-06-13 | 清华大学 | A kind of intraocular pressure monitoring device |
| CN107748128A (en) * | 2017-11-27 | 2018-03-02 | 郑州大学 | The biomechanical property test device and method of a kind of scaffold for vascular tissue engineering |
| CN207150855U (en) * | 2017-09-11 | 2018-03-27 | 上海博息电子科技有限公司 | A kind of high-performance composite heating film |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN87102483A (en) * | 1987-03-30 | 1988-10-12 | 浙江大学 | Electric resistance strain tube with metal wire |
| CN2240722Y (en) * | 1995-10-13 | 1996-11-20 | 东南大学 | Radial support force measuring meter for pipe shape net-shaped support frame |
| CN1109883C (en) * | 1999-06-02 | 2003-05-28 | 安泰科技股份有限公司 | Instrument and method for measuring supporting force of medical supporter |
| US20030110830A1 (en) * | 2001-07-23 | 2003-06-19 | Mark Dehdashtian | Methods and apparatuses for measuring the compliance of stents and stented grafts |
| WO2005099628A2 (en) * | 2004-04-13 | 2005-10-27 | Cook Incorporated | Implantable frame with variable compliance |
| CN100533845C (en) * | 2005-01-20 | 2009-08-26 | 皇家飞利浦电子股份有限公司 | Arrangement and method for monitoring pressure within a battery cell |
| CN100361636C (en) * | 2005-06-29 | 2008-01-16 | 东南大学 | Extracorporeal test device and method for the dilation performance of saccule dilating intravascular rack |
| CN101248988A (en) * | 2008-03-06 | 2008-08-27 | 西安交通大学 | Method for measuring blood pressure, pulse and vas compliance without inserting vas cavity |
| CN104502085B (en) * | 2014-12-18 | 2017-03-22 | 南京微创医学科技股份有限公司 | Testing device for fatigue property of medical self-expanding non-vascular lumen stent |
| CN105651630B (en) * | 2015-12-29 | 2019-03-05 | 东南大学 | Simulation material is in the fluid environment by the experimental provision for recycling tension and compression alternate load |
| CN206161438U (en) * | 2016-11-02 | 2017-05-10 | 郑州大学 | Blood vessel organizational project support mechanical properties test system |
-
2018
- 2018-07-16 CN CN201810787140.6A patent/CN108955990B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1839300A (en) * | 2003-08-20 | 2006-09-27 | 株式会社山武 | Pressure sensor device |
| WO2010022173A1 (en) * | 2008-08-19 | 2010-02-25 | Tissuegen, Inc. | Self-expanding medical device |
| CN102568720A (en) * | 2011-12-19 | 2012-07-11 | 北京东方计量测试研究所 | Tension constant resistor capable of calculating difference of alternating current and direct current |
| CN106821305A (en) * | 2017-03-23 | 2017-06-13 | 清华大学 | A kind of intraocular pressure monitoring device |
| CN207150855U (en) * | 2017-09-11 | 2018-03-27 | 上海博息电子科技有限公司 | A kind of high-performance composite heating film |
| CN107748128A (en) * | 2017-11-27 | 2018-03-02 | 郑州大学 | The biomechanical property test device and method of a kind of scaffold for vascular tissue engineering |
Non-Patent Citations (2)
| Title |
|---|
| The effect of stent graft oversizing on radial forces considering nitinol wire behavior and vessel characteristics;B.Senf 等;《Medical Engineering & Physics》;20141130;第36卷(第11期);第1480-1486页 * |
| 血管内膜表面温度差对识别兔腹主动脉易损斑块的价值;姜红峰 等;《中国动脉硬化杂志》;20130331(第3期);第215-219页 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN108955990A (en) | 2018-12-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108955992B (en) | Experimental device for blood vessel support holding power distributes in real-time supervision flow field environment | |
| CN108955990B (en) | Experimental device for radial holding power of vascular support in real-time supervision simulation environment | |
| Stella et al. | On the biaxial mechanical properties of the layers of the aortic valve leaflet | |
| Simon et al. | Reevaluation of arterial constitutive relations: A finite-deformation approach | |
| Kamenskiy et al. | Passive biaxial mechanical properties and in vivo axial pre-stretch of the diseased human femoropopliteal and tibial arteries | |
| Avanzini et al. | Biomechanical evaluation of ascending aortic aneurysms | |
| Vaishnav et al. | Effect of hypertension on elasticity and geometry of aortic tissue from dogs | |
| How et al. | The elastic properties of a polyurethane arterial prosthesis | |
| US10605700B2 (en) | Fatigue to fracture medical device testing method and system | |
| Hinnen et al. | Effect of intraluminal thrombus on pressure transmission in the abdominal aortic aneurysm | |
| Martufi et al. | The role of biomechanical modeling in the rupture risk assessment for abdominal aortic aneurysms | |
| Tonge et al. | Minimal preconditioning effects observed for inflation tests of planar tissues | |
| CN107748128A (en) | The biomechanical property test device and method of a kind of scaffold for vascular tissue engineering | |
| Kwon et al. | Intrasac pressure changes and vascular remodeling after endovascular repair of abdominal aortic aneurysms: review and biomechanical model simulation | |
| Wang et al. | Mechanical response of a metallic aortic stent—Part I: pressure-diameter relationship | |
| Wittek et al. | Characterization of the mechanical behavior and pathophysiological state of abdominal aortic aneurysms based on 4D ultrasound strain imaging | |
| Fatemifar et al. | Effect of axial stretch on lumen collapse of arteries | |
| CN209296486U (en) | A kind of evaluation system of external membrane tube shape organ-tissue ess-strain performance | |
| Wang et al. | Validation of the strain assessment of a phantom of abdominal aortic aneurysm: comparison of results obtained from magnetic resonance imaging and stereovision measurements | |
| DOBRIN et al. | Series elastic and contractile elements in vascular smooth muscle | |
| Berry et al. | A method to evaluate the elastic behavior of vascular stents | |
| Badal et al. | Multiphysics hemodynamic behavior of polylactic acid-based stent: a coupled simulation approach | |
| Arfaoui | Evaluation of a new instrument for measuring segmented radial force of SE-stents implemented in the LGF | |
| CN218885642U (en) | Vibrating type deep soil body side pressure testing device | |
| Raykin et al. | A phenomenological model for mechanically mediated growth, remodeling, damage, and plasticity of gel-derived tissue engineered blood vessels |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |