CN108955990A - A kind of experimental provision of real-time monitoring simulated environment medium vessels bracket radial support power - Google Patents

A kind of experimental provision of real-time monitoring simulated environment medium vessels bracket radial support power Download PDF

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CN108955990A
CN108955990A CN201810787140.6A CN201810787140A CN108955990A CN 108955990 A CN108955990 A CN 108955990A CN 201810787140 A CN201810787140 A CN 201810787140A CN 108955990 A CN108955990 A CN 108955990A
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radial support
bracket
transparent elastic
elastic pipe
pipe
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CN108955990B (en
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储成林
韩林原
张真玮
白晶
薛烽
郭超
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Southeast University
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Southeast University
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01LMEASURING FORCE, STRESS, TORQUE, WORK, MECHANICAL POWER, MECHANICAL EFFICIENCY, OR FLUID PRESSURE
    • G01L9/00Measuring steady of quasi-steady pressure of fluid or fluent solid material by electric or magnetic pressure-sensitive elements; Transmitting or indicating the displacement of mechanical pressure-sensitive elements, used to measure the steady or quasi-steady pressure of a fluid or fluent solid material, by electric or magnetic means
    • G01L9/02Measuring steady of quasi-steady pressure of fluid or fluent solid material by electric or magnetic pressure-sensitive elements; Transmitting or indicating the displacement of mechanical pressure-sensitive elements, used to measure the steady or quasi-steady pressure of a fluid or fluent solid material, by electric or magnetic means by making use of variations in ohmic resistance, e.g. of potentiometers, electric circuits therefor, e.g. bridges, amplifiers or signal conditioning
    • G01L9/04Measuring steady of quasi-steady pressure of fluid or fluent solid material by electric or magnetic pressure-sensitive elements; Transmitting or indicating the displacement of mechanical pressure-sensitive elements, used to measure the steady or quasi-steady pressure of a fluid or fluent solid material, by electric or magnetic means by making use of variations in ohmic resistance, e.g. of potentiometers, electric circuits therefor, e.g. bridges, amplifiers or signal conditioning of resistance-strain gauges

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Abstract

The invention discloses a kind of experimental provisions of real-time monitoring simulated blood vessel medium vessels bracket radial support power, including adjustable speed peristaltic pump (1), reservoir (2), water bath (3), silica gel hose (5) between bracket average radial support force monitoring device (4) and connecting components, the bracket average radial support force monitoring device (4) includes intravascular stent (6), internal layer polymer transparent elastic pipe (7), resistance-strain wire type transducer (8), outer layer copolymer transparent elastic pipe (9), polymeric transparent rigid pipe (10), fixing sleeve (11), data collector (12) and computer (13);The device can real-time monitoring intravascular stent in vitro in Flow Corrosion medium to the radial support power of simulated blood vessel.Experimental provision of the present invention can measure the average radial support force of unlike material, structural vessel bracket, of simple structure and low cost, easy to operate.

Description

A kind of experimental provision of real-time monitoring simulated environment medium vessels bracket radial support power
Technical field
The present invention relates to a kind of experimental provisions of real-time monitoring simulated environment medium vessels bracket radial support power, belong to medical treatment Instrument Mechanics Performance Testing field.
Background technique
The radial mechanical performance of intravascular stent is mainly reflected in intravascular stent to the resistance and intravascular stent of extraneous pressure To the adaptability to changes of external force action, this characteristic determines that can intravascular stent closely be attached into vascular wall.Support force Too small, intravascular stent lumen under blood vessel reaction force becomes smaller, and easily causes blood vessel embolism, and the medical treatment that can not play intravascular stent is made With, while easily intravascular stent is shifted under blood flow effect;And support force is excessive, will cause local vessel wall damage (as perforation, Tearing, rupture etc.), cause the excessive reparation of surrounding tissue to be reacted, causes endometrial hyperplasia etc..Therefore the average radial of intravascular stent Enabling capabilities are the important performance indexes for evaluating intravascular stent design structure.
Intravascular stent will receive the influence of blood flow and blood vessel pulsation, while the various lifes of human body in human body during one's term of military service Reason activity can also generate the effect of power to intravascular stent, cause the decaying of bracket radial mechanical performance, lose it to vascular wall Supporting role, cause the restenosis of blood vessel.For balloon expandable stent, when what it bore reaches it from extraneous pressure When critical value, intravascular stent can collapse or the permanent impairments such as buckling deformation, causes intravascular stent support force and rigidity Decline, this is for that can bear maximum radial pressure as the degradable blood vessel bracket that the degradation of bracket constantly reduces is particularly acute; Self-expanding type blood vessel dilator will not generally be occurred due to its high resiliency, good temperature memory effect and radial compliance Under certain action conditions bending deformation can occur for permanent deformation, although can restore after stress release to original shape, But its process can still damage patient.
In pharmaceuticals industry standard YY/T0663.2-2016, it is related to four about intravascular stent radial mechanical performance and determines Justice: radial crush resistance energy, anti-parallel-plate extrusion performance, local extrusion performance and radial support power.Radial crush resistance can be Balloon expandable stent resists the ability of permanent deformation under the action of by the radial load being uniformly distributed along the circumference;Anti- parallel-plate squeezes Pressure performance is the ability that bracket resists permanent deformation when by load equally distributed along integral support length;Local Squeezing ground It can be the ability that bracket resists permanent deformation when by local load (such as point load);Radial support power is that Self-expanded stent exists The power that the release stage generates vascular wall.
Since intravascular stent is many kinds of, the position for being applicable in lesion is not also identical, while national standard and professional standard are only The principle for providing directiveness, without the requirement of specific experimental method and technical parameter, therefore about intravascular stent radial mechanical The ununified standard of the test method and technical indicator of performance.The specific experiment method master of currently used radial mechanical performance Will there are three types of: the test of anti-parallel-plate extrusion performance, the test of anti-V-groove extrusion performance, radial anti-extrusion performance test and radial anti- Hydraulic test.The precision of the test of anti-parallel-plate extrusion performance and the test of anti-V-groove extrusion performance is higher, but support force mode with The practical mode of action in vascular environment is not identical, so can only be the indirect reflection to bracket radial strength;It is radial anti-crowded Pressure performance test simulates the practical radial force situation of bracket in the blood vessel, in the radial compression that acquisition blood vessel acts on bracket While power, bracket can also be obtained simultaneously to the chronic outreach power of blood vessel;Radial anti-hydraulic test also can preferable simulation bracket Stress morphology in the blood vessel, but precision is lower, and uncertain factor is more.
For the experimental study of intravascular stent radial mechanical performance key index, need a set of simple applicable and effective flat Equal radial support force test method, can accurately monitor intravascular stent in real time and be simulated in blood flow in vitro to simulated blood vessel Average radial support force device, the intravascular stent mechanical property of unlike material, structure can be investigated, to establish and improving blood The detection of pipe holder radial mechanical performance, appraisement system provide the theoretical foundation of science.
Summary of the invention
Technical problem: object of the present invention is to design a kind of reality of real-time monitoring simulated environment medium vessels bracket radial support power Experiment device, the device can the military service behavior of real simulation intravascular stent in the blood vessel, can monitor in real time bracket to simulation blood The average radial support force of pipe, and the flow in flow field, experimental temperature and corrosive medium are controllable, are suitable for different materials, ruler Very little and structure intravascular stent test specimen.
Technical solution: the present invention provides a kind of experiment of real-time monitoring simulated blood vessel medium vessels bracket radial support power dresses It sets, which includes adjustable speed peristaltic pump, reservoir, water bath, bracket average radial support force monitoring device and each portion of connection Silica gel hose between part, the silica gel hose run through the inside of adjustable speed peristaltic pump, and the connection of one end and reservoir, Its other end is connect with bracket average radial support force monitoring device, reservoir and bracket average radial support force monitoring device it Between linked together by another silica gel hose, constitute cyclic corrosion medium flow field environment;
The reservoir is arranged in water bath;
The bracket average radial support force monitoring device includes intravascular stent, internal layer polymer transparent elastic pipe, electricity Resistance strain wire type transducer, outer layer copolymer transparent elastic pipe, polymeric transparent rigid pipe, fixing sleeve, data collector and meter Calculation machine, the intravascular stent are mounted in the pipe of internal layer polymer transparent elastic pipe, the appearance of internal layer polymer transparent elastic pipe Face is wound with resistance-strain wire type transducer, and outer layer copolymer transparent elastic pipe is fitted in resistance-strain wire type transducer coil Outside, both and resistance-strain wire type transducer is wrapped in by internal layer polymer transparent elastic pipe and outer layer copolymer transparent elastic pipe Between, the outer layer copolymer transparent elastic pipe is mounted in polymeric transparent rigid pipe by fixing sleeve, data collector It is connected with resistance-strain wire type transducer, and is connect with computer.
Wherein:
The flow velocity and flow of corrosive medium in the adjustable speed peristaltic pump control experimental provision, reservoir replacement experiment dress Interior corrosive medium is set, the water bath temperature is adjustable, for adjusting the temperature for adjusting corrosive medium in experimental provision.
The internal layer polymer transparent elastic pipe and outer layer copolymer transparent elastic pipe are simulated blood vessel wall, and interior layers of polymer The pipe thickness of object transparent elastic pipe and outer layer copolymer transparent elastic pipe is for 0.1~0.5mm, and material is polyurethane PU, terylene or expanded PTFE.
The wall thickness of the polymeric transparent rigid pipe be 1mm~5mm, material be PMMA, that is, polymethyl methacrylate, PP, that is, polypropylene, PVC, that is, polyvinyl chloride, PC, that is, polycarbonate or ABS, that is, polyacrylonitrile.
The outer surface of the internal layer polymer transparent elastic pipe is wound with resistance-strain wire type transducer, refers to using resistance Straining silk, uniformly circumferential winding, screw pitch are 0.03~0.5mm in the outer surface of internal layer polymer transparent elastic pipe, are allowed to coil Shape is covered on the outer surface that internal layer polymer transparent elastic pipe is coated with intravascular stent region, measures intravascular stent domain of the existence Average radial support force, pass through corresponding software real-time display intravascular stent and internal layer polymer transparent elastic pipe and outer layers of polymer The average contact pressure data between simulated blood vessel wall that object transparent elastic pipe is constituted, obtain being averaged for intravascular stent region Radial pressure value, and carry out data analysis.
The coil method of the resistance-strain wire type transducer be alloy wire or semiconductor silk material, it is a diameter of 0.015~0.05mm, and the sensitivity coefficient of the alloy wire is 2~6, semiconductor silk material sensitivity coefficient is 150 or more.
The alloy wire or semiconductor silk material is corronil, Aludirome, nichrome, platinum or platinum alloy One of.
The bracket average radial support force monitoring device is used for simulated blood vessel medium vessels bracket during the experiment Average radial support force or simulated blood vessel in the average radial compressing force of bracket is monitored, dynamometry range be 0.0006~ 170MPa。
The bracket average radial support force monitoring device is suitable for the reality of the intravascular stent of different sizes, material and construction When measure.
The internal layer polymer transparent elastic pipe, resistance-strain wire type transducer, outer layer copolymer transparent elastic pipe and The face that contacts with each other between polymeric transparent rigid pipe is smooth, and fitting is without opposite sliding.
The intravascular stent along the circumferential direction contacts internal layer polymer transparent elastic pipe, and directly act on be coated on it is inside and outside On resistance-strain wire type transducer in layer elastic tube, the radial force being applied on intravascular stent is divided evenly, and acts on biography The force value of sensor coil is acquired by the change in resistance of sensor.
The utility model has the advantages that compared with prior art, beneficial effects of the present invention are as follows:
1) the actual average stress condition of experimental provision real simulation intravascular stent provided by the invention in the blood vessel.With it is normal Anti- parallel-plate extrusion performance test experiments are different, and it is the radial load along bracket circumference uniform distribution that the present apparatus, which measures the data obtained, Stress situation of the intravascular stent in human vas is more realistically reacted in effect, is pressed obtaining blood vessel the radial direction that bracket acts on While contracting power, bracket can also be obtained simultaneously to the chronic outreach power of blood vessel.In addition to the human body of capillary and capillary lymph duct Blood vessel, vascular wall are broadly divided into three-decker: inner membrance, middle film and outer membrane, respectively by endothelial cell, smooth muscle cell and connective Organizational composition mainly provides mechanical support by layer of smooth muscle cells, therefore selects elastic material, such as polyurethane is as simulation blood Tube wall, to reach the mechanical property to match with blood vessel, and the micro phase separation structure that polyurethane material has is very similar Organism blood vessel: being macroscopically very smooth surface, and it is microcosmic on be a lipid bilayer fluid matrix layer, in Between be embedded with all kinds of glycoprotein and glycolipid matter;The high molecular polymers materials such as other materials such as terylene, expanded PTFE (ePTFE) The artificial blood vessel of material manufacture also has reached realistic scale.Meanwhile the flow fields environment that device generates can really simulate blood Flowing, speed, flow and the temperature-controllable in flow field.
2) experimental provision provided by the invention can accurately monitor intravascular stent site of action to simulated blood vessel in real time Average radial support force.Compared to the passive radial Mechanics Performance Testing of intravascular stent, which can obtain intravascular stent pair The real-time average radial of simulated blood vessel military service process supports force data, and obtains the big microsatellite of average radial support force by software Outer simulated experiment carries out time extension and the dynamic data that changes, can be with more intuitive more scientific evaluation intravascular stent in the blood vessels Radial support power variation during military service.
3) experimental provision provided by the invention is simple, low in cost, applied widely, can be to different sizes, material and structure The intravascular stent made carries out the real-time measurement of radial support power, while experimental temperature, and flow field flow, corrosive medium is adjustable, With general applicability.
Detailed description of the invention
Fig. 1 is a kind of schematic diagram of the experimental provision of real-time monitoring simulated blood vessel medium vessels bracket radial support power;
Fig. 2 is the schematic diagram of bracket average radial support force monitoring device;
Have in figure: adjustable speed peristaltic pump 1, reservoir 2, water bath 3, bracket average radial support force monitoring device 4, silica gel Hose 5 including intravascular stent 6, internal layer polymer transparent elastic pipe 7, resistance-strain wire type transducer 8, outer layer copolymer are transparent Elastic tube 9, polymeric transparent rigid pipe 10, fixing sleeve 11, data collector 12 and computer 13.
Specific embodiment
The present invention provides a kind of intravascular stent that can accurately monitor in real time and is simulated in blood flow environment in vitro to simulation The device of the average radial support force of blood vessel, suitable for for Flow Corrosion medium, intravascular stent is average to simulated blood vessel wall The real-time measurement of radial support power effect, the present invention will be further explained with reference to the accompanying drawing.
As shown in Figure 1, a kind of experimental provision of real-time monitoring simulated blood vessel medium vessels bracket radial support power, including it is adjustable Silica gel between fast peristaltic pump 1, reservoir 2, water bath 3, bracket average radial support force monitoring device 4 and connecting components is soft Pipe 5, the silica gel hose 5 run through the inside of adjustable speed peristaltic pump 1, and the connection of one end and reservoir 2, the other end and Bracket average radial support force monitoring device 4 connects, and passes through between reservoir 2 and bracket average radial support force monitoring device 4 Another silica gel hose 5 links together, and constitutes cyclic corrosion medium flow field environment;Reservoir 2 is arranged in water bath 3;
The adjustable speed peristaltic pump 1 controls the flow velocity and flow of corrosive medium in experimental provision, the replacement experiment of reservoir 2 Corrosive medium in device, 3 temperature of water bath is adjustable, for adjusting the temperature for adjusting corrosive medium in experimental provision Degree;
As shown in Fig. 2, bracket average radial support force monitoring device 4 includes intravascular stent 6, internal layer polymer transparent elastic Pipe 7, resistance-strain wire type transducer 8, outer layer copolymer transparent elastic pipe 9, polymeric transparent rigid pipe 10, fixing sleeve 11, number According to collector 12 and computer 13, the intravascular stent 6 is mounted in the pipe of internal layer polymer transparent elastic pipe 7, interior layers of polymer The outer surface of object transparent elastic pipe 7 is wound with resistance-strain wire type transducer 8, and outer layer copolymer transparent elastic pipe 9 is fitted in electricity Outside resistance strain 8 coil of wire type transducer, and internal layer polymer transparent elastic pipe 7 and outer layer copolymer transparent elastic pipe 9 are by resistance Strain wire type transducer 8 is wrapped in therebetween, and the outer layer copolymer transparent elastic pipe 9 is mounted on poly- by fixing sleeve 11 It closes in object transparent rigid pipe 10, data collector 12 is connected with resistance-strain wire type transducer 8, and connect with computer 13;
9 wall thickness 0.05 of pipe of the internal layer polymer transparent elastic pipe 7 and outer layer copolymer transparent elastic pipe~ 0.5mm, material therefor are that polyurethane PU, terylene, expanded PTFE (ePTFE) etc. have mechanical property similar with vascular wall The polymer material of energy;10 wall thickness of polymer rigid pipe is 1mm~5mm, and material therefor is polymetylmethacrylate, gathers Propylene PP, polyvinylchloride, polycarbonate, polyacrylonitrile ABS etc. have the poly- of preferable mechanical stability and corrosion resistance Close object material.
The outer surface of the internal layer polymer transparent elastic pipe 7 is wound with resistance-strain wire type transducer 8, refers to using electricity For resistance strain silk in the uniformly circumferential winding of the outer surface of internal layer polymer transparent elastic pipe 7, screw pitch is 0.03~0.5mm, be allowed to Coiled type is covered on the outer surface that internal layer polymer transparent elastic pipe 7 is coated with 8 region of intravascular stent, measures intravascular stent 8 The average radial support force of domain of the existence passes through corresponding software real-time display intravascular stent and internal layer polymer transparent elastic pipe 7 The average contact pressure data of the simulated blood vessel wall constituted with outer layer copolymer transparent elastic pipe 9 obtain intravascular stent location The Average Radial Pressure value in domain, and carry out data analysis.
The coil method of the resistance-strain wire type transducer 8 be alloy wire or semiconductor silk material, a diameter of 0.015 ~0.05mm, the alloy wire sensitivity coefficient are 2~6, and semiconductor silk material sensitivity coefficient is 150 or more.
The alloy wire or semiconductor silk material is corronil, Aludirome, nichrome, platinum or platinum alloy Deng.
The bracket average radial support force monitoring device 4 is used for simulated blood vessel medium vessels bracket 6 in experimentation In average radial support force or simulated blood vessel in the average radial compressing force of bracket is monitored, dynamometry range be 0.0006 ~170MPa, the real-time measurement of the intravascular stent 6 suitable for different sizes, material and construction.
The internal layer polymer transparent elastic pipe 7, resistance-strain wire type transducer 8, outer layer copolymer transparent elastic pipe 9 The face that contacts with each other between polymeric transparent rigid pipe 10 is smooth, and fitting is without opposite sliding.
The intravascular stent 6 along the circumferential direction contacts internal layer polymer transparent elastic pipe 7, and in directly acting on and being coated on On resistance-strain wire type transducer 8 in outer layer elastic tube, the radial force being applied on intravascular stent 6 is divided evenly, effect It is acquired in the force value of cell winding by the change in resistance of sensor.
Embodiment 1
Device as shown in Figure 2 selects the intravascular stent 6 of test that can drop for the WE43 magnesium alloy balloon-expandable of braiding forming Intravascular stent is solved, the bracket held with a firm grip of pressure is preloaded on foley's tube, is transported in internal layer PU transparent elastic pipe 7, using filling Pressure pump Filled Balloon be full of to nominal pressure, bracket is by internal layer PU transparent elastic pipe 7, nichrome resistance-strain wire coil 8, outer Layer PU transparent elastic pipe 9 is outwardly against while stent-expansion, the sacculus of distal end of catheter are withdrawn from after decompression is shunk, use Corrosive medium is simulating blood plasma solution, and temperature is 37 DEG C, flow field velocity is controlled by adjustable speed peristaltic pump 1, in corrosive medium stream In body, the radial support power of magnesium alloy bracket is constantly reduced with the degradation of itself, can record bracket average radial branch in real time Support force influences research to the degradation of degradable magnesium alloy bracket for load and provides scientific basis with the decaying of degradation process.
Embodiment 2
Device used is identical as case study on implementation 1, and the intravascular stent 6 of the test of selection is the NiTi shape of laser engraving forming Shape memory alloys self-expanding type blood vessel dilator, bracket is preloaded on delivery conduit, is placed in PU transparent elastic pipe 7, is led to It crosses silica gel hose 5 to be connected on simulation blood circulation device, the corrosive medium used passes through adjustable speed peristaltic pump for simulating blood plasma 1 control flow field velocity, adjusting temperature is 37 DEG C, reaches the transition temperature of alloy, and bracket gradually deforms expansion and produces to elastic tube Raw support force selects constantan wire to strain silk as metallic resistance, records being averaged in stent-expansion process and retraction process in real time Influence of the blood flow to intravascular stent radial support power is studied in the variation of radial support power.
To make the object, technical solutions and advantages of the present invention clearer, the technical solution below in the present invention carries out clear Chu is fully described by, it is clear that described case study on implementation is a part of case study on implementation of the present invention, rather than whole implementation cases Example.Based on the case study on implementation in the present invention, those of ordinary skill in the art are obtained without making creative work Every other case study on implementation, shall fall within the protection scope of the present invention.

Claims (9)

1. a kind of experimental provision of real-time monitoring simulated blood vessel medium vessels bracket radial support power, it is characterised in that: the device packet Include adjustable speed peristaltic pump (1), reservoir (2), water bath (3), bracket average radial support force monitoring device (4) and each portion of connection Silica gel hose (5) between part, the silica gel hose (5) run through the inside of adjustable speed peristaltic pump (1), and one end and liquid storage The connection of slot (2), the other end are connect with bracket average radial support force monitoring device (4), reservoir (2) and bracket average diameter It links together to another silica gel hose (5) is passed through between support force monitoring device (4), constitutes cyclic corrosion medium flow field ring Border;
Reservoir (2) setting is in water bath (3);
The bracket average radial support force monitoring device (4) includes intravascular stent (6), internal layer polymer transparent elastic pipe (7), resistance-strain wire type transducer (8), outer layer copolymer transparent elastic pipe (9), polymeric transparent rigid pipe (10), fixing sleeve (11), data collector (12) and computer (13), the intravascular stent (6) are mounted on internal layer polymer transparent elastic pipe (7) Pipe in, the outer surface of internal layer polymer transparent elastic pipe (7) is wound with resistance-strain wire type transducer (8), outer layer copolymer Transparent elastic pipe (9) is fitted in outside resistance-strain wire type transducer (8) coil, and internal layer polymer transparent elastic pipe (7) and outer Resistance-strain wire type transducer (8) is wrapped in therebetween by one polymer transparent elastic pipe (9), and the outer layer copolymer is saturating Bright elastic tube (9) is mounted in polymeric transparent rigid pipe (10) by fixing sleeve (11), and data collector (12) is answered with resistance Become wire type transducer (8) to be connected, and is connect with computer (13).
2. a kind of experimental provision of real-time monitoring simulated environment medium vessels bracket radial support power as described in claim 1, Be characterized in that: the internal layer polymer transparent elastic pipe (7) and outer layer copolymer transparent elastic pipe (9) are simulated blood vessel wall, and The pipe thickness of internal layer polymer transparent elastic pipe (7) and outer layer copolymer transparent elastic pipe (9) be for 0.1~0.5mm, Material is polyurethane PU, terylene or expanded PTFE.
3. a kind of experimental provision of real-time monitoring simulated environment medium vessels bracket radial support power as described in claim 1, Be characterized in that: the wall thickness of the polymeric transparent rigid pipe (10) is 1mm~5mm, and material is PMMA, that is, polymethylacrylic acid Methyl esters, PP, that is, polypropylene, PVC, that is, polyvinyl chloride, PC, that is, polycarbonate or ABS, that is, polyacrylonitrile.
4. a kind of experimental provision of real-time monitoring simulated environment medium vessels bracket radial support power as described in claim 1, Be characterized in that: the outer surface of the internal layer polymer transparent elastic pipe (7) is wound with resistance-strain wire type transducer (8), refers to Using resistance-strain silk in the uniformly circumferential winding of the outer surface of internal layer polymer transparent elastic pipe (7), screw pitch is 0.03~ 0.5mm is allowed to be covered on the outer surface that internal layer polymer transparent elastic pipe (7) is coated with intravascular stent (8) region with coiled type, Measure the average radial support force of intravascular stent (8) domain of the existence.
5. a kind of experimental provision of real-time monitoring simulated environment medium vessels bracket radial support power as described in claim 1, Be characterized in that: the coil method of the resistance-strain wire type transducer (8) be alloy wire or semiconductor silk material, it is a diameter of 0.015~0.05mm, and the sensitivity coefficient of the alloy wire is 2~6, semiconductor silk material sensitivity coefficient is 150 or more.
6. a kind of experimental provision of real-time monitoring simulated environment medium vessels bracket radial support power as claimed in claim 5, Be characterized in that: the alloy wire or semiconductor silk material is that corronil, Aludirome, nichrome, platinum or platinum close One of gold.
7. a kind of experimental provision of real-time monitoring simulated environment medium vessels bracket radial support power as described in claim 1, Be characterized in that: the bracket average radial support force monitoring device (4) is for testing simulated blood vessel medium vessels bracket (6) The average radial compressing force of bracket is monitored in average radial support force or simulated blood vessel in the process, dynamometry range is 0.0006~170MPa.
8. a kind of experimental provision of real-time monitoring simulated environment medium vessels bracket radial support power as described in claim 1, It is characterized in that: the internal layer polymer transparent elastic pipe (7), resistance-strain wire type transducer (8), the transparent bullet of outer layer copolymer Property pipe (9) and polymeric transparent rigid pipe (10) between the face that contacts with each other it is smooth, fitting is without opposite sliding.
9. a kind of experimental provision of real-time monitoring simulated environment medium vessels bracket radial support power as described in claim 1, Be characterized in that: water bath (3) temperature is adjustable.
CN201810787140.6A 2018-04-19 2018-07-16 Experimental device for radial holding power of vascular support in real-time supervision simulation environment Active CN108955990B (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114452033A (en) * 2022-04-13 2022-05-10 深圳市库珀科技发展有限公司 Ureteral stent and test device thereof
CN115672431A (en) * 2022-10-18 2023-02-03 哈尔滨工业大学(威海) Extracorporeal circulation and intraluminal intervention isolated blood vessel constant temperature auxiliary device

Citations (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN87102483A (en) * 1987-03-30 1988-10-12 浙江大学 Electric resistance strain tube with metal wire
CN2240722Y (en) * 1995-10-13 1996-11-20 东南大学 Radial support force measuring meter for pipe shape net-shaped support frame
CN1245286A (en) * 1999-06-02 2000-02-23 安泰科技股份有限公司 Instrument and method for measuring supporting force of medical supporter
US20030110830A1 (en) * 2001-07-23 2003-06-19 Mark Dehdashtian Methods and apparatuses for measuring the compliance of stents and stented grafts
US20050228486A1 (en) * 2004-04-13 2005-10-13 Case Brian C Implantable frame with variable compliance
CN1739463A (en) * 2005-06-29 2006-03-01 东南大学 Extracorporeal test device and method for the dilation performance of saccule dilating intravascular rack
CN1839300A (en) * 2003-08-20 2006-09-27 株式会社山武 Pressure sensor device
CN101107747A (en) * 2005-01-20 2008-01-16 皇家飞利浦电子股份有限公司 Arrangement and method for monitoring pressure within a battery cell
CN101248988A (en) * 2008-03-06 2008-08-27 西安交通大学 Method for measuring blood pressure, pulse and vas compliance without inserting vas cavity
WO2010022173A1 (en) * 2008-08-19 2010-02-25 Tissuegen, Inc. Self-expanding medical device
CN102568720A (en) * 2011-12-19 2012-07-11 北京东方计量测试研究所 Tension constant resistor capable of calculating difference of alternating current and direct current
CN104502085A (en) * 2014-12-18 2015-04-08 南京微创医学科技有限公司 Testing device for fatigue property of medical self-expanding non-vascular lumen stent
CN105651630A (en) * 2015-12-29 2016-06-08 东南大学 Experimental device for simulating cycle tension and compression alternating load of material in fluid environment
CN206161438U (en) * 2016-11-02 2017-05-10 郑州大学 Blood vessel organizational project support mechanical properties test system
CN106821305A (en) * 2017-03-23 2017-06-13 清华大学 A kind of intraocular pressure monitoring device
CN107748128A (en) * 2017-11-27 2018-03-02 郑州大学 The biomechanical property test device and method of a kind of scaffold for vascular tissue engineering
CN207150855U (en) * 2017-09-11 2018-03-27 上海博息电子科技有限公司 A kind of high-performance composite heating film

Patent Citations (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN87102483A (en) * 1987-03-30 1988-10-12 浙江大学 Electric resistance strain tube with metal wire
CN2240722Y (en) * 1995-10-13 1996-11-20 东南大学 Radial support force measuring meter for pipe shape net-shaped support frame
CN1245286A (en) * 1999-06-02 2000-02-23 安泰科技股份有限公司 Instrument and method for measuring supporting force of medical supporter
US20030110830A1 (en) * 2001-07-23 2003-06-19 Mark Dehdashtian Methods and apparatuses for measuring the compliance of stents and stented grafts
CN1839300A (en) * 2003-08-20 2006-09-27 株式会社山武 Pressure sensor device
US20050228486A1 (en) * 2004-04-13 2005-10-13 Case Brian C Implantable frame with variable compliance
CN101107747A (en) * 2005-01-20 2008-01-16 皇家飞利浦电子股份有限公司 Arrangement and method for monitoring pressure within a battery cell
CN1739463A (en) * 2005-06-29 2006-03-01 东南大学 Extracorporeal test device and method for the dilation performance of saccule dilating intravascular rack
CN101248988A (en) * 2008-03-06 2008-08-27 西安交通大学 Method for measuring blood pressure, pulse and vas compliance without inserting vas cavity
WO2010022173A1 (en) * 2008-08-19 2010-02-25 Tissuegen, Inc. Self-expanding medical device
CN102568720A (en) * 2011-12-19 2012-07-11 北京东方计量测试研究所 Tension constant resistor capable of calculating difference of alternating current and direct current
CN104502085A (en) * 2014-12-18 2015-04-08 南京微创医学科技有限公司 Testing device for fatigue property of medical self-expanding non-vascular lumen stent
CN105651630A (en) * 2015-12-29 2016-06-08 东南大学 Experimental device for simulating cycle tension and compression alternating load of material in fluid environment
CN206161438U (en) * 2016-11-02 2017-05-10 郑州大学 Blood vessel organizational project support mechanical properties test system
CN106821305A (en) * 2017-03-23 2017-06-13 清华大学 A kind of intraocular pressure monitoring device
CN207150855U (en) * 2017-09-11 2018-03-27 上海博息电子科技有限公司 A kind of high-performance composite heating film
CN107748128A (en) * 2017-11-27 2018-03-02 郑州大学 The biomechanical property test device and method of a kind of scaffold for vascular tissue engineering

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
B.SENF 等: "The effect of stent graft oversizing on radial forces considering nitinol wire behavior and vessel characteristics", 《MEDICAL ENGINEERING & PHYSICS》 *
姜红峰 等: "血管内膜表面温度差对识别兔腹主动脉易损斑块的价值", 《中国动脉硬化杂志》 *
程洁 等: "冠脉支架的多功能体外力学性能测试装置及实验研究", 《东南大学学报》 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114452033A (en) * 2022-04-13 2022-05-10 深圳市库珀科技发展有限公司 Ureteral stent and test device thereof
CN114452033B (en) * 2022-04-13 2022-07-01 深圳市库珀科技发展有限公司 Ureteral stent and test device thereof
CN115672431A (en) * 2022-10-18 2023-02-03 哈尔滨工业大学(威海) Extracorporeal circulation and intraluminal intervention isolated blood vessel constant temperature auxiliary device

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