CN1089496A - Compound sodium alginati diesteras - Google Patents
Compound sodium alginati diesteras Download PDFInfo
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- CN1089496A CN1089496A CN 93110233 CN93110233A CN1089496A CN 1089496 A CN1089496 A CN 1089496A CN 93110233 CN93110233 CN 93110233 CN 93110233 A CN93110233 A CN 93110233A CN 1089496 A CN1089496 A CN 1089496A
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- China
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- diesteras
- alginati
- propylene glycol
- sodium sulfate
- salviae miltiorrhizae
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- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a kind of compound sodium alginati diesteras, it is to have increased salviamiltiorrhizabung and Radix Notoginseng powder on the basis of propylene glycol alginate sodium sulfate, makes capsule then.Compatibility salviamiltiorrhizabung and Radix Notoginseng can significantly reduce the untoward reaction that propylene glycol alginate sodium sulfate self is brought in principal agent, can reach the purpose of diseases of cardiovascular and cerebrovascular systems treating both the principal and secondary aspects of a disease again.
Description
The present invention relates to a kind of heparinoid medicine of producing with sodium alginate, particularly a kind of have anticoagulation, a compound sodium alginati diesteras of blood fat reducing.
At present the propylene glycol alginate sodium sulfate of producing is to have anticoagulation, blood fat reducing by sodium alginate through what hydrolysis, esterification and sulfonation were made, and the new drug of microcirculation improvement effect is mainly used in and prevents ischemic cerebrovascular.But, clinical discovery in recent years: take this medicine for a long time and be prone to mucous hyperemia and oozing of blood; Incidence rate of adverse reaction such as hypotension and vaginal hemorrhage is directly proportional with dosage (see for details " new drug and clinical " 1989 JIUYUE the 289th, 290 pages), how to reduce the poison of propylene glycol alginate sodium sulfate and pays effect, has become a current important topic.
The object of the present invention is to provide a kind ofly on the basis that does not lessen the curative effect, reduce its side effect, and increase blood circulation promoting and blood stasis dispelling, prevent and treat coronary heart disease, the compound sodium alginati diesteras of disease such as uncomfortable in chest and angina pectoris.
The object of the present invention is achieved like this: on the basis that reduces the propylene glycol alginate sodium sulfate dose, increase salviamiltiorrhizabung and auxiliary Chinese medicine Radix Notoginseng.Clinical proof when the day dose of propylene glycol alginate sodium sulfate drops to a certain degree, can reach the poison effect of paying and obviously reduce, and its drug effect influence but is not very big.Radix Salviae Miltiorrhizae contains multiple active ingredients such as TANSHINONES, Radix Salviae Miltiorrhizae quinone, danshensu, can influence multiple thrombin, improve hemorheological property and reduce surface activity of blood platelet, anticoagulant, improve the activity of fibrinoclase, also have anticoagulant and prevent thrombotic effect.Therefore, under the situation of day dose that reduces propylene glycol alginate sodium sulfate,, can strengthen the drug effect of propylene glycol alginate sodium sulfate by increasing Radix Salviae Miltiorrhizae.Radix Salviae Miltiorrhizae and active ingredient thereof also can increase patient's coronary flow, promote side Zhi Xunhuan, improve myocardium microcirculation, and do not increase cardiac work and myocardial oxygen consumption, therefore, it all has curative effect preferably to treatment coronary heart disease, myocarditis, arrhythmia, angina pectoris and peripheral blood vessel.In addition, the effect of paying of the poison of Radix Salviae Miltiorrhizae is little, and hemogram and hepatic and renal function are not had obvious influence, is particularly suitable for and the propylene glycol alginate sodium sulfate compatibility.
The Chinese medicine Radix Notoginseng, arasaponin R wherein
1Then have dissipating blood stasis hemostasis Deng active ingredient, the function of subduing swelling and relieving pain, untoward reaction such as hyperemia that the principal agent blood vessel dilating causes and oozing of blood can be lowered in it and principal agent compatibility, heighten the effect of a treatment the side effect of minimizing principal agent.
In the propylene glycol alginate sodium sulfate principal agent, the compound sodium alginati diesteras that compatibility salviamiltiorrhizabung and Radix Notoginseng are made can significantly reduce the untoward reaction that propylene glycol alginate sodium sulfate self is brought, and can reach the purpose of diseases of cardiovascular and cerebrovascular systems treating both the principal and secondary aspects of a disease.
Embodiment:
Get quantitative Radix Salviae Miltiorrhizae, added for the first time 90% alcohol reflux 1.5 hours, filter, filtrate recycling ethanol is concentrated into relative density 1.30(55～60 ℃); Add for the second time 50% alcohol reflux 1.5 hours, filter; Add water for the third time and refluxed 2 hours, filter.Merge two, three times filtrate, reclaim ethanol, be concentrated into relative density 1.40(55～60 ℃), merge with the above-mentioned concentrated solution first time again, mixing is made Radix Salviae Miltiorrhizae and is soaked lamb (55～60 ℃ time relative density be 1.35～1.39).
After the Radix Notoginseng powder of 141 grams are broken into 80 purpose fine powders, with the Radix Salviae Miltiorrhizaes of 125 grams soak lamb mix thoroughly, dry, granulate, take by weighing propylene glycol alginate sodium sulfate 25 grams by the prescription regulation again, with above medicated powder mixing, the granulate that sieves, encapsulated 1000.
This compound sodium alginati diesteras is taken 2～3 at every turn,, the control of heart and brain blood disorders diseases such as ischemic cerebrovascular, hyperlipemia, coronary heart disease, uncomfortable in chest, angina pectoris there is obvious curative effects for three times on the one, or medication under physician guidance, mucous hyperemia, bad reflections such as oozing of blood and hypotension obviously reduce.
Claims (3)
1, a kind of compound sodium alginati diesteras is characterized in that: the proportioning as active ingredient is:
Every capsules contains propylene glycol alginate sodium sulfate 0.025 gram
Radix Salviae Miltiorrhizae soaks lamb 0.125 gram
Radix Notoginseng powder 0.141 gram
2, compound sodium alginati diesteras according to claim 1 is characterized in that: Radix Salviae Miltiorrhizae soaks lamb and adds alcohol reflux by Radix Salviae Miltiorrhizae and filter and to make, and when 55～60 ℃ of temperature, its relative density is 1.35～1.39.
3, compound sodium alginati diesteras according to claim 2, its preparation method is: Radix Notoginseng powder is broken into 80 purpose fine powders, soaks lamb with Radix Salviae Miltiorrhizae and mix thoroughly, dry then, granulation, with propylene glycol alginate sodium sulfate granule mixing, the granulate that sieves is dressed up capsule again.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93110233 CN1089496A (en) | 1993-01-06 | 1993-01-06 | Compound sodium alginati diesteras |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93110233 CN1089496A (en) | 1993-01-06 | 1993-01-06 | Compound sodium alginati diesteras |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1089496A true CN1089496A (en) | 1994-07-20 |
Family
ID=4988124
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 93110233 Pending CN1089496A (en) | 1993-01-06 | 1993-01-06 | Compound sodium alginati diesteras |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1089496A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1059679C (en) * | 1993-06-18 | 2000-12-20 | 青岛海洋大学 | Sodium alginate diester and preparation method |
| CN100484543C (en) * | 2004-12-21 | 2009-05-06 | 四川迪康科技药业股份有限公司 | Medicament composition for treating hepatitis, prepartion method and use |
-
1993
- 1993-01-06 CN CN 93110233 patent/CN1089496A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1059679C (en) * | 1993-06-18 | 2000-12-20 | 青岛海洋大学 | Sodium alginate diester and preparation method |
| CN100484543C (en) * | 2004-12-21 | 2009-05-06 | 四川迪康科技药业股份有限公司 | Medicament composition for treating hepatitis, prepartion method and use |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) |