CN108939143A - A kind of preparation method of polyethylene glycol medical university areas of skin dressing - Google Patents
A kind of preparation method of polyethylene glycol medical university areas of skin dressing Download PDFInfo
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- CN108939143A CN108939143A CN201810739902.5A CN201810739902A CN108939143A CN 108939143 A CN108939143 A CN 108939143A CN 201810739902 A CN201810739902 A CN 201810739902A CN 108939143 A CN108939143 A CN 108939143A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0019—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0061—Use of materials characterised by their function or physical properties
- A61L26/0066—Medicaments; Biocides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/80—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special chemical form
- A61L2300/802—Additives, excipients, e.g. cyclodextrins, fatty acids, surfactants
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Abstract
A kind of preparation method of polyethylene glycol medical university areas of skin dressing.The invention discloses a kind of preparation methods of polyethylene glycol medical accessory, specifically includes the following steps: preparing the modified beta-cyclodextrin of Polyacrylamide Grafted first；Prepare curative drug solution；Then the modified beta-cyclodextrin of Polyacrylamide Grafted obtained above is immersed in the solution, it is stirred 30-50min, then chitosan acetic acid solution is added, glutaraldehyde solution is continuously added after stirring, stirring crosslinking reacts 1-3h at 30-40 DEG C, is cooled to room temperature after reaction, is eventually adding polyethylene glycol, medical glycerine, it is uniformly mixed, medical dressing is made.Medical accessory produced by the present invention can effectively facilitate wound healing, and biological safety is good, and have certain anti-microbial property.
Description
Technical field:
The present invention relates to medical dressing fields, are specifically related to a kind of preparation method of polyethylene glycol medical dressing.
Background technique:
There is a large amount of defect of skin patient in China and the whole nation every year, as long as safety accident, fire victim and because of disease
Caused skin ulcer patient, chemical industry and present industrial expansion, modern weapons and the war to take place frequently, make fire victim's number
Annual high, with the increasing sharply of aged's ratio, the deterioration of environment, the whole world is because big caused by the diseases such as diabetes
Areas of skin ulcer person increases therewith.Therefore, the demand of medical accessory is increased increasingly.
But existing medical accessory is during union of wounded skin now, there are healing times long, easy scar hyperplasia,
Situations such as easily dry and cracked, in use, there are poor air permeability, degradations slowly, is not easy to absorb, treat for current existing medical accessory
Imitate the disadvantages of unobvious.
Summary of the invention:
The object of the present invention is to provide a kind of preparation method of polyethylene glycol medical dressing, polyethylene glycol made from this method
Medical dressing is liquid-type, and stability is good, biodegradable, may advantageously facilitate wound healing, has certain anti-microbial property.
To achieve the above object, the invention adopts the following technical scheme:
A kind of preparation method of polyethylene glycol medical dressing, comprising the following steps:
(1) beta-cyclodextrin and deionized water are mixed to join in reactor, then sequentially add acrylamide monomers,
Emulsifier is warming up to 70-80 DEG C, is stirred 5-10min, and initiator is then added dropwise, and reacts 1-2h, is cooled to after reaction
Room temperature filters, dry, and the modified beta-cyclodextrin of Polyacrylamide Grafted is made；
(2) curative drug solution is prepared；Then the modified beta-cyclodextrin of Polyacrylamide Grafted obtained above is immersed
Into the solution, it is stirred 30-50min, chitosan acetic acid solution is then added, continuously adds glutaraldehyde solution after stirring,
Stirring crosslinking reacts 1-3h at 30-40 DEG C, is cooled to room temperature after reaction, is eventually adding polyethylene glycol, medical glycerine, stirs
It is uniformly mixed, medical dressing is made.
As a preferred embodiment of the above technical solution, in step (1), the beta-cyclodextrin, deionized water, acrylic amide list
Body, emulsifier, initiator dosage be respectively as follows: 4-9 parts of beta-cyclodextrin, 20-30 parts of deionized water, acrylamide in parts by weight
5-10 parts of class monomer, 0.06-0.1 parts of emulsifier, 0.05-0.1 parts of initiator.
As a preferred embodiment of the above technical solution, in step (1), the acrylamide monomers are acrylamide, 2- propylene
One of amide groups -2- methyl propane sulfonic acid sodium.
As a preferred embodiment of the above technical solution, in step (1), the initiator is potassium peroxydisulfate.
As a preferred embodiment of the above technical solution, in step (1), the emulsifier is Tween 80.
As a preferred embodiment of the above technical solution, in step (2), the curative drug is anti-inflammatory drugs, anesthesia class medicine
One of object, hemostasis class drug, antiviral class drug, analgesic type drug, the mass concentration of curative drug solution is 5-
10%.
As a preferred embodiment of the above technical solution, in step (2), the concentration of the acetic acid solution is 10%, chitosan and second
The mass ratio of acid solution is 1:(8-11).
As a preferred embodiment of the above technical solution, the mass concentration of the glutaraldehyde solution is 5-15%.
As a preferred embodiment of the above technical solution, in step (2), the dosage of each component is respectively as follows: in parts by weight to be controlled
10-15 parts of drug solution of the property treated, Polyacrylamide Grafted modified beta-cyclodextrin 3-7 parts, 10-20 parts of chitosan acetic acid solution, penta
4-10 parts of dialdehyde solution, 10-30 parts of polyethylene glycol, 8-15 parts of medical glycerine.
Compared with prior art, the invention has the following advantages:
Beta-cyclodextrin has certain inclusion, effectively inclusion compound can be prepared by mixing into drug, to increase drug
Biocompatibility effectively plays the effect of sustained release, but its dissolubility in water is low, and inclusion property less stable；To understand
Certainly this technical problem, the present invention in beta-cyclodextrin surface grafting polyacrylamide, effectively increase beta-cyclodextrin in water first
In dissolution dispersity；Then it will be added in curative drug solution, inclusion processing realized, in order to realize the better of drug
Sustained release performance, a certain amount of chitosan acetic acid solution is added in the present invention, and crosslinks under the action of glutaraldehyde solution, is wrapping
Close the surface-crosslinked one layer of chitosan gel rubber of object；
Medical dressing stability produced by the present invention is good, can effectively realize the sustained release performance of curative drug, and have one
Fixed anti-microbial property.
Specific embodiment:
In order to better understand the present invention, below by embodiment, the present invention is further described, and embodiment is served only for solving
The present invention is released, any restriction will not be constituted to the present invention.
Embodiment 1
A kind of preparation method of polyethylene glycol medical dressing, which comprises the following steps:
(1) beta-cyclodextrin and deionized water are mixed to join in reactor, then sequentially add acrylamide monomers,
Emulsifier is warming up to 70-80 DEG C, is stirred 5-10min, and initiator is then added dropwise, and reacts 1h, is cooled to room after reaction
Temperature filters, dry, and the modified beta-cyclodextrin of Polyacrylamide Grafted is made；Wherein, the dosage of each component is distinguished in parts by weight
Are as follows: 4 parts of beta-cyclodextrin, 20 parts of deionized water, 5 parts of acrylamide monomers, 0.06 part of emulsifier, 0.05 part of initiator；
(2) curative drug solution is prepared；Then the modified beta-cyclodextrin of Polyacrylamide Grafted obtained above is immersed
Into the solution, it is stirred 30min, chitosan acetic acid solution is then added, glutaraldehyde solution, 30- are continuously added after stirring
Stirring crosslinking reacts 1h at 40 DEG C, is cooled to room temperature after reaction, is eventually adding polyethylene glycol, medical glycerine, is stirred
Uniformly, medical dressing is made；Wherein, the mass ratio of chitosan and acetic acid solution is 1:8；The dosage of each component is divided in parts by weight
Not are as follows: 10 parts of curative drug solution, Polyacrylamide Grafted modified 3 parts of beta-cyclodextrin, 10 parts of chitosan acetic acid solution, penta 2
4 parts of aldehyde solution, 10 parts of polyethylene glycol, 8 parts of medical glycerine.
Embodiment 2
A kind of preparation method of polyethylene glycol medical dressing, which comprises the following steps:
(1) beta-cyclodextrin and deionized water are mixed to join in reactor, then sequentially add acrylamide monomers,
Emulsifier is warming up to 70-80 DEG C, is stirred 5-10min, and initiator is then added dropwise, and reacts 2h, is cooled to room after reaction
Temperature filters, dry, and the modified beta-cyclodextrin of Polyacrylamide Grafted is made；Wherein, the dosage of each component is distinguished in parts by weight
Are as follows: 9 parts of beta-cyclodextrin, 30 parts of deionized water, 10 parts of acrylamide monomers, 0.1 part of emulsifier, 0.1 part of initiator；
(2) curative drug solution is prepared；Then the modified beta-cyclodextrin of Polyacrylamide Grafted obtained above is immersed
Into the solution, it is stirred 50min, chitosan acetic acid solution is then added, glutaraldehyde solution, 30- are continuously added after stirring
Stirring crosslinking reacts 3h at 40 DEG C, is cooled to room temperature after reaction, is eventually adding polyethylene glycol, medical glycerine, is stirred
Uniformly, medical dressing is made；Wherein, the mass ratio of chitosan and acetic acid solution is 1:11；The dosage of each component is in parts by weight
It is respectively as follows: 15 parts of curative drug solution, Polyacrylamide Grafted modified 7 parts of beta-cyclodextrin, 20 parts of chitosan acetic acid solution, penta
10 parts of dialdehyde solution, 30 parts of polyethylene glycol, 15 parts of medical glycerine.
Embodiment 3
A kind of preparation method of polyethylene glycol medical dressing, which comprises the following steps:
(1) beta-cyclodextrin and deionized water are mixed to join in reactor, then sequentially add acrylamide monomers,
Emulsifier is warming up to 70-80 DEG C, is stirred 5-10min, and initiator is then added dropwise, and reacts 1.2h, is cooled to after reaction
Room temperature filters, dry, and the modified beta-cyclodextrin of Polyacrylamide Grafted is made；Wherein, the dosage of each component is distinguished in parts by weight
Are as follows: 5 parts of beta-cyclodextrin, 22 parts of deionized water, 6 parts of acrylamide monomers, 0.07 part of emulsifier, 0.06 part of initiator；
(2) curative drug solution is prepared；Then the modified beta-cyclodextrin of Polyacrylamide Grafted obtained above is immersed
Into the solution, it is stirred 35min, chitosan acetic acid solution is then added, glutaraldehyde solution, 30- are continuously added after stirring
Stirring crosslinking reacts 1.5h at 40 DEG C, is cooled to room temperature after reaction, is eventually adding polyethylene glycol, medical glycerine, and stirring is mixed
It closes uniformly, medical dressing is made；Wherein, the mass ratio of chitosan and acetic acid solution is 1:8.5；The dosage of each component is with parts by weight
Meter be respectively as follows: modified 4 parts of the beta-cyclodextrin of 11 parts of curative drug solution, Polyacrylamide Grafted, 12 parts of chitosan acetic acid solution,
5 parts of glutaraldehyde solution, 15 parts of polyethylene glycol, 10 parts of medical glycerine.
Embodiment 4
A kind of preparation method of polyethylene glycol medical dressing, which comprises the following steps:
(1) beta-cyclodextrin and deionized water are mixed to join in reactor, then sequentially add acrylamide monomers,
Emulsifier is warming up to 70-80 DEG C, is stirred 5-10min, and initiator is then added dropwise, and reacts 1.6h, is cooled to after reaction
Room temperature filters, dry, and the modified beta-cyclodextrin of Polyacrylamide Grafted is made；Wherein, the dosage of each component is distinguished in parts by weight
Are as follows: 6 parts of beta-cyclodextrin, 24 parts of deionized water, 7 parts of acrylamide monomers, 0.08 part of emulsifier, 0.07 part of initiator；
(2) curative drug solution is prepared；Then the modified beta-cyclodextrin of Polyacrylamide Grafted obtained above is immersed
Into the solution, it is stirred 40min, chitosan acetic acid solution is then added, glutaraldehyde solution, 30- are continuously added after stirring
Stirring crosslinking reacts 2h at 40 DEG C, is cooled to room temperature after reaction, is eventually adding polyethylene glycol, medical glycerine, is stirred
Uniformly, medical dressing is made；Wherein, the mass ratio of chitosan and acetic acid solution is 1:9.5；The dosage of each component is in parts by weight
It is respectively as follows: 12 parts of curative drug solution, Polyacrylamide Grafted modified 5 parts of beta-cyclodextrin, 14 parts of chitosan acetic acid solution, penta
6 parts of dialdehyde solution, 20 parts of polyethylene glycol, 12 parts of medical glycerine.
Embodiment 5
A kind of preparation method of polyethylene glycol medical dressing, which comprises the following steps:
(1) beta-cyclodextrin and deionized water are mixed to join in reactor, then sequentially add acrylamide monomers,
Emulsifier is warming up to 70-80 DEG C, is stirred 5-10min, and initiator is then added dropwise, and reacts 1.6h, is cooled to after reaction
Room temperature filters, dry, and the modified beta-cyclodextrin of Polyacrylamide Grafted is made；Wherein, the dosage of each component is distinguished in parts by weight
Are as follows: 7 parts of beta-cyclodextrin, 26 parts of deionized water, 8 parts of acrylamide monomers, 0.08 part of emulsifier, 0.08 part of initiator；
(2) curative drug solution is prepared；Then the modified beta-cyclodextrin of Polyacrylamide Grafted obtained above is immersed
Into the solution, it is stirred 40min, chitosan acetic acid solution is then added, glutaraldehyde solution, 30- are continuously added after stirring
Stirring crosslinking reacts 2h at 40 DEG C, is cooled to room temperature after reaction, is eventually adding polyethylene glycol, medical glycerine, is stirred
Uniformly, medical dressing is made；Wherein, the mass ratio of chitosan and acetic acid solution is 1:10；The dosage of each component is in parts by weight
It is respectively as follows: 13 parts of curative drug solution, Polyacrylamide Grafted modified 6 parts of beta-cyclodextrin, 16 parts of chitosan acetic acid solution, penta
7 parts of dialdehyde solution, 25 parts of polyethylene glycol, 14 parts of medical glycerine.
Embodiment 6
A kind of preparation method of polyethylene glycol medical dressing, which comprises the following steps:
(1) beta-cyclodextrin and deionized water are mixed to join in reactor, then sequentially add acrylamide monomers,
Emulsifier is warming up to 70-80 DEG C, is stirred 5-10min, and initiator is then added dropwise, and reacts 1.8h, is cooled to after reaction
Room temperature filters, dry, and the modified beta-cyclodextrin of Polyacrylamide Grafted is made；Wherein, the dosage of each component is distinguished in parts by weight
Are as follows: 8 parts of beta-cyclodextrin, 28 parts of deionized water, 9 parts of acrylamide monomers, 0.09 part of emulsifier, 0.09 part of initiator；
(2) curative drug solution is prepared；Then the modified beta-cyclodextrin of Polyacrylamide Grafted obtained above is immersed
Into the solution, it is stirred 45min, chitosan acetic acid solution is then added, glutaraldehyde solution, 30- are continuously added after stirring
Stirring crosslinking reacts 2.5h at 40 DEG C, is cooled to room temperature after reaction, is eventually adding polyethylene glycol, medical glycerine, and stirring is mixed
It closes uniformly, medical dressing is made；Wherein, the mass ratio of chitosan and acetic acid solution is 1:10；The dosage of each component is with parts by weight
Meter is respectively as follows: 14 parts of curative drug solution, Polyacrylamide Grafted modified 6.5 parts of beta-cyclodextrin, chitosan acetic acid solution 18
Part, 9 parts of glutaraldehyde solution, 25 parts of polyethylene glycol, 14 parts of medical glycerine.
Polyethylene glycol medical dressing produced by the present invention is used for 150 third-degree burn patients, 98% patient is 5
Surface of a wound is just clearly better after it, and the surface of a wound heals completely after 7 days, and no scar generates, and all patients all dressing is with good
Adaptability, in use, phenomena such as surface of a wound is not in redness, pain, infection.
Polyethylene glycol medical dressing produced by the present invention has certain sustained release performance, through detecting, slow-release time to drug
It can continue nearly 200 hours, release rate is 95% or more.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto,
Anyone skilled in the art in the technical scope disclosed by the present invention, according to the technique and scheme of the present invention and its
Inventive concept is subject to equivalent substitution or change, should be covered by the protection scope of the present invention.
Claims (9)
1. a kind of preparation method of polyethylene glycol medical dressing, which comprises the following steps:
(1) beta-cyclodextrin and deionized water are mixed to join in reactor, then sequentially add acrylamide monomers, emulsification
Agent is warming up to 70-80 DEG C, is stirred 5-10min, and initiator is then added dropwise, and reacts 1-2h, is cooled to room after reaction
Temperature filters, dry, and the modified beta-cyclodextrin of Polyacrylamide Grafted is made；
(2) curative drug solution is prepared；Then the modified beta-cyclodextrin of Polyacrylamide Grafted obtained above is immersed in this
In solution, it is stirred 30-50min, chitosan acetic acid solution is then added, glutaraldehyde solution, 30-40 are continuously added after stirring
Stirring crosslinking reacts 1-3h at DEG C, is cooled to room temperature after reaction, is eventually adding polyethylene glycol, medical glycerine, is stirred
Uniformly, medical dressing is made.
2. a kind of preparation method of polyethylene glycol medical dressing as described in claim 1, which is characterized in that in step (1), institute
State beta-cyclodextrin, deionized water, acrylamide monomers, emulsifier, initiator dosage be respectively as follows: β-ring paste in parts by weight
4-9 parts smart, 20-30 parts of deionized water, 5-10 parts of acrylamide monomers, 0.06-0.1 parts of emulsifier, initiator 0.05-0.1
Part.
3. a kind of preparation method of polyethylene glycol medical dressing as described in claim 1, it is characterised in that: in step (1), institute
Stating acrylamide monomers is one of acrylamide, 2- acrylamide-2-methylpro panesulfonic acid sodium.
4. a kind of preparation method of polyethylene glycol medical dressing as described in claim 1, it is characterised in that: in step (1), institute
Stating initiator is potassium peroxydisulfate.
5. a kind of preparation method of polyethylene glycol medical dressing as described in claim 1, it is characterised in that: in step (1), institute
Stating emulsifier is Tween 80.
6. a kind of preparation method of polyethylene glycol medical dressing as described in claim 1, it is characterised in that: in step (2), institute
Curative drug is stated as one in anti-inflammatory drugs, anesthesia class drug, hemostasis class drug, antiviral class drug, analgesic type drug
Kind, the mass concentration of curative drug solution is 5-10%.
7. a kind of preparation method of polyethylene glycol medical dressing as described in claim 1, it is characterised in that: in step (2), institute
The concentration for stating acetic acid solution is 10%, and the mass ratio of chitosan and acetic acid solution is 1:(8-11).
8. a kind of preparation method of polyethylene glycol medical dressing as described in claim 1, it is characterised in that: the glutaraldehyde is molten
The mass concentration of liquid is 5-15%.
9. a kind of preparation method of polyethylene glycol medical dressing as described in claim 1, which is characterized in that in step (2), institute
The dosage for stating each component is respectively as follows: the modified β of 10-15 parts of curative drug solution, Polyacrylamide Grafted-ring paste in parts by weight
3-7 parts smart, 10-20 parts of chitosan acetic acid solution, 4-10 parts of glutaraldehyde solution, 10-30 parts of polyethylene glycol, medical glycerine 8-15
Part.
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