CN108939137A - A kind of compound hemostatic powder and preparation method thereof - Google Patents
A kind of compound hemostatic powder and preparation method thereof Download PDFInfo
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- CN108939137A CN108939137A CN201811059654.6A CN201811059654A CN108939137A CN 108939137 A CN108939137 A CN 108939137A CN 201811059654 A CN201811059654 A CN 201811059654A CN 108939137 A CN108939137 A CN 108939137A
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- modified starch
- compound hemostatic
- preparation
- hemostatic powder
- powder
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L24/0073—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix
- A61L24/0094—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with a macromolecular matrix containing macromolecular fillers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0015—Medicaments; Biocides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0042—Materials resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
Abstract
The present invention relates to a kind of hemostatic material, especially a kind of compound hemostatic powder and preparation method thereof.The compound hemostatic powder, it is characterised in that it is that 1:10-20 is configured that the compound hemostatic powder is by bletilla polysaccharide and modified starch by weight.The preparation method of compound hemostatic powder, preparation process are as follows: the preparation of modified starch, the preparation of compound hemostatic powder.The technical scheme is that being modified using ethanol solution to uncooked amylum, modified starch has biggish specific surface area and hole configurations, astringing to arrest bleeding, the characteristic of promotion platelet aggregation having simultaneously using bletilla polysaccharide, using modified starch as the carrier of bletilla polysaccharide, it is attached to bletilla polysaccharide in the hole configurations of modified starch, the characteristic of bletilla polysaccharide is played, this feature of the high-hydroscopicity of modified starch is utilized again, the body fluid that wound can be absorbed rapidly, condenses wound rapidly.
Description
Technical field
The present invention relates to a kind of hemostatic material, especially a kind of compound hemostatic powder and preparation method thereof.
Background technique
Blood loss becomes the lethal factor of wound and the war wound wounded, and with the fast development of medical technology, range of operation is not yet
It is disconnected to expand, therefore fast-acting nemostatic becomes the critical issue of emergency care of trauma, post-operative recovery.Current clinically common hemostatic material kind
Class is more, but respectively has certain limitation, such as more micropore hemostatic starchs preparation process is relatively cumbersome, adhesion property compared with
Difference, mechanical strength are low；Gelatin class material is due to coming from ox-hide, easily causing allergic reaction and aggravating infection；Chitosan itself stops
Blood effect is limited, less desirable for the haemostatic effect of the large-area hemorrhage surface of a wound；Meeting very exothermic causes to hurt after zeolite water suction
Mouth thermal damage, if residue long-term existence can cause chronic inflammation, therefore is only used for stopping blooding in short term.And it is some compound
Hemostatic material has embodied advantage in clinic, not only has good biocompatibility, also compensates for respective deficiency, mention
High anthemorrhagic performance.Therefore, study it is a kind of can quick-acting haemostatic powder, reduce the death rate, save the cost, easy to use, and organize phase
The good new compound hemostatic material of capacitive seems especially popular.Currently, compound hemostatic material mainly has oxazepan hemostatic material
(chitosan and collagen form), absorbable fibre protein adhesive, chitosan/alginic acid hemostatic material, gelatin-PVA- chitosan
Film, composite micro-powder polysaccharide styptic powder (plant amylum and chitosan form) etc. is lyophilized.
The bletilla striata is a kind of traditional Chinese medicine, has astringing to arrest bleeding, the effect of detumescence and promoting granulation, external application can control wound hemorrhage, carbuncle swells,
Scald, furunculosis etc..Studies have shown that bletilla striata water logging extract --- bletilla polysaccharide stops parenchymatous organ, muscle vascular bleeding etc.
Blood effect is quite good, and the main active principle of this extract is polysaccharide component, and the polysaccharide biocompatibility is good.
Summary of the invention
The object of the present invention is to provide a kind of hemostatic, good biocompatibility and can body absorption degradation one kind it is compound only
Blood meal and preparation method thereof.
The technical scheme is that a kind of compound hemostatic powder, it is characterised in that the compound hemostatic powder is by bletilla polysaccharide
It is by weight that 1:10-20 is configured with modified starch.
Above-mentioned modified starch is to be modified by uncooked amylum using Ethanol Method, and water absorption rate is 154-222% or so.
The method for preparing compound hemostatic powder described in the claims, preparation process are as follows:
Step 1: the preparation of modified starch: taking uncooked amylum 10g, the ethyl alcohol that 40mL weight percent concentration is 30% is added, 60
Water-bath flows back 1 hour at DEG C, and it is spare that modified starch 1 is obtained after freeze-drying；
Step 2: the preparation of compound hemostatic powder: taking bletilla polysaccharide 1g, is added in 40g pure water after completely dissolution, modified starch is added
10g is stirred and evenly mixed, and after being uniformly mixed 5min with eddy mixer, freeze-drying obtains compound hemostatic material.
The technical scheme is that being modified using ethanol solution to uncooked amylum, modified starch has biggish ratio
Surface area and hole configurations, while the astringing to arrest bleeding having using bletilla polysaccharide, the characteristic for promoting platelet aggregation, form sediment modified
Carrier of the powder as bletilla polysaccharide, is attached to bletilla polysaccharide in the hole configurations of modified starch, that is, has played bletilla polysaccharide
Characteristic, and this feature of the high-hydroscopicity of modified starch is utilized, the body fluid of wound can be absorbed rapidly, coagulate wound rapidly
Knot.
Compound hemostatic powder described in technical solution of the present invention has rapid hemostasis, good biocompatibility and can inhale in vivo
The characteristics of incorporating solution.Freeze-drying can keep the water absorbing properties of styptic powder simultaneously, while ensure that bletilla polysaccharide will not be by high temperature
Influence and degrade.
Specific embodiment
Embodiment 1:
Step 1: the preparation of modified starch: 10g uncooked amylum being added in the ethyl alcohol 40mL that weight percent concentration is 30%,
Water-bath flows back 1 hour at 60 DEG C, and freeze-drying obtains modified starch 10g, spare；Detected the water absorption rate 222% of the modified starch
Step 2: it the preparation of compound hemostatic powder: takes bletilla polysaccharide 1g to be added in 40g pure water after completely dissolution, modified starch is added
10g is stirred and evenly mixed, and after being uniformly mixed 5min with eddy mixer, freeze-drying obtains compound hemostatic material 11g.
Detected external 152.2 ± 6.7s of clotting time of the styptic powder
Embodiment 2-4:
On the basis of one step 1 of embodiment, change the dosage and water-bath reflux temperature of the ethyl alcohol that weight percent concentration is 30%
Degree and time, remaining condition are constant.
| Embodiment | Ethyl alcohol | Temperature DEG C | Time |
| Embodiment 2 | 40mL | 60 | 1 |
| Embodiment 3 | 50mL | 70 | 2 |
| Embodiment 4 | 60mL | 80 | 4 |
The modified starch that above-described embodiment 2 obtains, water absorption rate 221.85%.
The modified starch that above-described embodiment 3 obtains, water absorption rate 163.34%.
The modified starch that above-described embodiment 4 obtains, water absorption rate 154.57%.
Above-mentioned water absorption index is bigger, illustrates that material water absorbing properties are better.
Embodiment 5-7:
On the basis of above-mentioned any embodiment, the dosage of modified starch and pure water in two is changed the step, remaining condition is constant.
| Embodiment | Bletilla polysaccharide | Pure water quality | Modified starch quality |
| Embodiment 5 | 1 | 25 | 10 |
| Embodiment 6 | 1 | 40 | 10 |
| Embodiment 7 | 1 | 50 | 20 |
The styptic powder that above-described embodiment 5 obtains, external 187.2 ± 5.2s of clotting time.
The styptic powder that above-described embodiment 6 obtains, external 158.5 ± 6.7s of clotting time.
The styptic powder that above-described embodiment 7 obtains, external 201.6 ± 4.2s of clotting time.
Above-mentioned external clotting time index is smaller, illustrates that material anthemorrhagic performance performance is better.
Claims (3)
1. a kind of compound hemostatic powder, it is characterised in that it is 1 that the compound hemostatic powder is by bletilla polysaccharide and modified starch by weight:
10-20 configure.
2. bletilla striata extract compound hemostatic powder according to claim 1, it is characterised in that above-mentioned modified starch is formed sediment by raw
Powder is modified using Ethanol Method, and water absorption rate is 154-222% or so.
3. the method for preparing compound hemostatic powder described in the claims, preparation process are as follows:
Step 1: the preparation of modified starch: taking uncooked amylum 10g, the ethyl alcohol that 40mL weight percent concentration is 30% is added, 60
Water-bath flows back 1 hour at DEG C, and it is spare that modified starch 1 is obtained after freeze-drying；
Step 2: the preparation of compound hemostatic powder: taking bletilla polysaccharide 1g, is added in 40g pure water after completely dissolution, modified starch is added
10g is stirred and evenly mixed, and after being uniformly mixed 5min with eddy mixer, freeze-drying obtains compound hemostatic material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811059654.6A CN108939137A (en) | 2018-09-12 | 2018-09-12 | A kind of compound hemostatic powder and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811059654.6A CN108939137A (en) | 2018-09-12 | 2018-09-12 | A kind of compound hemostatic powder and preparation method thereof |
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| Publication Number | Publication Date |
|---|---|
| CN108939137A true CN108939137A (en) | 2018-12-07 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201811059654.6A Pending CN108939137A (en) | 2018-09-12 | 2018-09-12 | A kind of compound hemostatic powder and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112295011A (en) * | 2020-10-28 | 2021-02-02 | 赛克赛斯生物科技股份有限公司 | Composite microporous polysaccharide medical material, preparation method and application thereof, and hemostatic and bacteriostatic preparation |
| CN113101406A (en) * | 2021-04-06 | 2021-07-13 | 浙江工业大学 | Starch composition and application thereof in preparation of hemostatic material |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103349791A (en) * | 2013-07-29 | 2013-10-16 | 广西信业生物技术有限公司 | Novel microporous medical hemostatic material and preparation method thereof |
| CN103467770A (en) * | 2013-09-23 | 2013-12-25 | 天津科技大学 | Preparation method of novel porous starch |
| CN104546893A (en) * | 2014-01-07 | 2015-04-29 | 北京大清生物技术有限公司 | Biodegradable and absorbable hemostasis composition |
| CN105688266A (en) * | 2016-01-22 | 2016-06-22 | 广西信业生物技术有限公司 | Composite medical biofiber bleeding-arresting powder material and preparation method thereof |
-
2018
- 2018-09-12 CN CN201811059654.6A patent/CN108939137A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103349791A (en) * | 2013-07-29 | 2013-10-16 | 广西信业生物技术有限公司 | Novel microporous medical hemostatic material and preparation method thereof |
| CN103467770A (en) * | 2013-09-23 | 2013-12-25 | 天津科技大学 | Preparation method of novel porous starch |
| CN104546893A (en) * | 2014-01-07 | 2015-04-29 | 北京大清生物技术有限公司 | Biodegradable and absorbable hemostasis composition |
| CN105688266A (en) * | 2016-01-22 | 2016-06-22 | 广西信业生物技术有限公司 | Composite medical biofiber bleeding-arresting powder material and preparation method thereof |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112295011A (en) * | 2020-10-28 | 2021-02-02 | 赛克赛斯生物科技股份有限公司 | Composite microporous polysaccharide medical material, preparation method and application thereof, and hemostatic and bacteriostatic preparation |
| CN112295011B (en) * | 2020-10-28 | 2023-02-21 | 赛克赛斯生物科技股份有限公司 | Composite microporous polysaccharide medical material, preparation method and application thereof, and hemostatic and bacteriostatic preparation |
| CN113101406A (en) * | 2021-04-06 | 2021-07-13 | 浙江工业大学 | Starch composition and application thereof in preparation of hemostatic material |
| CN113101406B (en) * | 2021-04-06 | 2022-06-21 | 浙江工业大学 | Starch composition and application thereof in preparation of hemostatic material |
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Application publication date: 20181207 |