CN108939127A - A kind of anesthesia surgery hemostatic and antibacterial auxiliary material and preparation method thereof - Google Patents
A kind of anesthesia surgery hemostatic and antibacterial auxiliary material and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of anesthesia surgery hemostatic and antibacterial auxiliary materials, it is related to a kind of anesthesia surgery auxiliary material, including the moisture absorption layer and outer layer being arranged from inside to outside, multiple circular holes are uniformly arranged on the moisture absorption layer, antibiotic layer is arranged in the circular hole and moisture absorption layer outer surface, and the outer layer is cotton fiber or bamboo charcoal fiber；The moisture absorption layer is prepared from the following raw materials in parts by weight: 90-100 parts of acrylic acid, N, 3-5 parts of N- methylene-bisacrylamide, 5-6 parts of bentonite, 10-12 parts of polyvinyl alcohol, 5-8 parts of polymer alumina, 4-6 parts of glycerol and 0.1-0.3 parts of initiator.The hemostatic and antibacterial auxiliary material moisture absorption is good, and anti-microbial property is excellent, and the wound for being conducive to Postoperative and anesthesia is restored.
Description
Technical field
The present invention relates to a kind of anesthesia surgery auxiliary materials, more particularly, to a kind of anesthesia surgery hemostatic and antibacterial auxiliary material and its system
Preparation Method.
Background technique
Anesthesia surgery is clinical medical pith, it can be ensured that patient it is painless with safety under conditions of successfully connect
By operative treatment, the pain of patient is eliminated, to smoothly perform the operation.Wound hemostasis processing and art during anesthesia surgery
A large amount of antibacterial anti hemorrhagic auxiliary material is required in wound healing process afterwards, the effect of auxiliary material is hemostasis, prevents bacterium infection, promotes wound
Mouth healing etc..
Chinese patent notification number CN207627485U discloses a kind of antiseptic anti-adhesion combine dressing, successively includes from inside to outside
Layer of silica gel, load have collagen hydrogels layer, the froth bed of antimicrobial component；Uniform intervals are laid with through entire in layer of silica gel
The imbibing hole of layer of silica gel；Layer of silica gel and the size of froth bed are all larger than the collagen hydrogels layer that load has antimicrobial component.Wound
Mouth diffusate enters collagen hydrogels layer by imbibing hole, and collagen hydrogels are gradually molten under the action of diffusate
Solution releases antimicrobial component, and antimicrobial component is applied to wound by imbibing hole, realizes and acts on the antibiotic anti-infection of wound, gram
The defect for playing its antibacterial action can not be discharged well by taking traditional dressing antimicrobial component；The size of froth bed and layer of silica gel
It is all larger than hydrogel layer, is formed and hydrogel layer is folded in intermediate structure, realizes and the ring protection of hydrogel layer is acted on, keep away
Exempt from collagen hydrogels after encountering diffusate dissolution to outer spilling.
China Patent Publication No. CN 106975095A discloses a kind of antibacterial medical auxiliary material and preparation method thereof, belongs to medical
Auxiliary material field, the antibacterial medical auxiliary material include the raw material of following parts by weight: 40-50 parts of cotton fiber, carboxymethyl chitosan 10-
15 parts, 2-3 parts of nano zine oxide, 20-30 parts of sodium alginate, sea misty 20-30 parts of sheath, 20-30 parts of Herba Lycopi, 20-30 parts of folium isatidis
With 20-30 parts of rheum officinale.The antibacterial medical auxiliary material is blended with cotton fiber and sodium alginate, addition carboxymethyl chitosan, nano oxidized
Zinc and Chinese medical extract, and cotton fiber is pre-processed, preparation method is improved, the moisture pick-up properties of medical dressing is substantially increased
And anti-microbial property；But medical accessory surface layer after absorbing wound exudate can be hardened in the invention, influence its anti-microbial property.
Summary of the invention
In view of this, in view of the deficiencies of the prior art, it is an object of the present invention to provide a kind of anesthesia surgery hemostatic and antibacterial is auxiliary
Material, moisture absorption is good, and anti-microbial property is excellent, and the wound for being conducive to Postoperative and anesthesia is restored.
In order to achieve the above objectives, the invention adopts the following technical scheme:
A kind of anesthesia surgery hemostatic and antibacterial auxiliary material, it is uniform on the moisture absorption layer including the moisture absorption layer and outer layer being arranged from inside to outside
Multiple circular holes are set, and the circular hole is interior and antibiotic layer is arranged in moisture absorption layer outer surface, and the outer layer is cotton fiber or bamboo charcoal fiber
Cloth；
The moisture absorption layer is prepared from the following raw materials in parts by weight: 90-100 parts of acrylic acid, N, N- methylene-bisacrylamide 3-5
Part, 5-6 parts of bentonite, 10-12 parts of polyvinyl alcohol, 5-8 parts of polymer alumina, 4-6 parts of glycerol and 0.1-0.3 parts of initiator.
Further, the antibiotic layer is prepared from the following raw materials in parts by weight: 45-55 parts of cotton fiber, nano zine oxide
2-3 parts, 25-35 parts of Radix Notoginseng, 25-35 parts of setose thistle, 25-35 parts of cattail pollen and 25-35 parts of folium isatidis.
Further, the initiator is sodium peroxydisulfate or potassium peroxydisulfate.
Further, the moisture absorption layer is made of following steps: 1-1.5 times of water dissolution, condition of ice bath being added in acrylic acid
The dissolution of lower dropwise addition potassium hydroxide carries out neutralization reaction, degree of neutralization 60-70%, sequentially added under stirring polyvinyl alcohol, bentonite,
Polymer alumina, glycerol, crosslinking agent N, N- methylene-bisacrylamide and initiator continue to stir 15-20min, be subsequently poured into
In mold, 100 DEG C of drying after 3-4h.
Further, the anesthesia surgery hemostatic and antibacterial auxiliary material, is made of following steps:
1) in a solvent, ultrasonic mixing 40-60min obtains cotton spinning solution for cotton fiber dissolution；
2) it is 80% ethanol solution, refluxing extraction 2- that 6-8 times of volume fraction is added after mixing Radix Notoginseng, setose thistle, cattail pollen and folium isatidis
3h, combined extract, being concentrated into relative density is 1.3-1.5, obtains herb liquid；
3) moisture absorption layer is cut into circular hole, and herb liquid, nano zine oxide are added in cotton spinning solution and are stirred evenly, then in moisture absorption layer
Upper carry out electrostatic spinning forms antibiotic layer, and then cotton fiber or bamboo charcoal fiber are arranged on the outside of antibiotic layer, obtain product.
Further, the solvent in the step (1) is DMAC/LiCl mixed solvent.
The pharmacological action for the Chinese medicine that the present invention uses is:
Radix Notoginseng: sweet, slight bitter, temperature return liver, stomach meridian.Major function: dissipating stasis and stanching bleeding, detumescence ding-tong.For spitting blood, haematemesis, bleeding from five sense organs or subcutaneous tissue,
Hematochezia, metrorrhagia and metrostaxis, traumatic hemorrhage, chest and abdomen twinge, tumbling and swelling.
Setose thistle: sweet, bitter, cool, converge to heart and liver channels.Major function: cooling blood and hemostasis, eliminating stasis to resolve swelling.For bleeding from five sense organs or subcutaneous tissue, spit blood, urine
Blood, hematochezia, metrostaxis, traumatic hemorrhage, carbuncle sore tumefacting virus.
Cattail pollen: sweet and neutral returns liver, pericardium channel.Major function: hemostasis, stagnation resolvation is treating stranguria.For spitting blood, bleeding from five sense organs or subcutaneous tissue, hemoptysis collapses
Leakage, traumatic hemorrhage, amenorrhea and algomenorrhea, stomach duct and abdomen shouting pain, tumbling and swelling, blood strangury and dry pain.
Folium isatidis: it is bitter, it trembles with fear, return heart, stomach meridian.Major function: clearing heat and detoxicating, blood cooling and ecchymoses removing.It joins the army for warm heresy, high fever mind
Dusk, spot dermexanthesis, jaundice, hot dysentery, mumps, sore throat, erysipelas, carbuncle swells.
The beneficial effects of the present invention are:
1, the present invention discloses a kind of anesthesia surgery hemostatic and antibacterial auxiliary material, including the moisture absorption layer and outer layer being arranged from inside to outside, wherein
Outer layer is layer 2-3 cotton fiber or bamboo charcoal fiber cloth, is not only breathed freely, moreover it is possible to stop bacterial invasion；It is uniformly arranged on moisture absorption layer more
A circular hole, circular hole is interior and antibiotic layer is arranged in moisture absorption layer outer surface, and moisture absorption layer and antibiotic layer are arranged in a crossed manner, the leaching of wound surface
Liquid can restore, using effect is good as early as possible after moisture absorption layer absorbs under the action of antibiotic layer.
2, the moisture absorption layer in the application is by acrylic acid and N, and absorb water tree made of N- methylene-bisacrylamide is crosslinked
Rouge, wherein being also added with polyvinyl alcohol, acrylic acid and polyvinyl alcohol compatibility are good, and blended cross linking can have complementary advantages, and improve and inhale
The film forming and hygroscopicity of wet layer；And it is also added with polymer alumina, polymer alumina is distributed in resin network structure, can mention
Absorbent properties of the highly hygroscopic layer to wound fluid；Glycerol and bentonite are also added in the moisture absorption layer of another aspect the application,
During cross-linking reaction, bentonite is will disperse under the action of glycerol on the surface layer of moisture absorption layer resin network structure, works as moisture absorption
After layer contact wetting, bentonite is evenly dispersed as skeleton particle, and gelation after capable of preventing resin network structure from absorbing water makes water
Dividing can uniformly enter inside moisture absorption layer, to increase the water absorption rate of the application.
3, the antibiotic layer in the application is as cotton fiber through being wherein also added with three in cotton spinning solution made of electrostatic spinning
Seven, the extracting solution of setose thistle, cattail pollen and folium isatidis, wherein Radix Notoginseng, setose thistle, cattail pollen and folium isatidis have hemostasis, detumescence and antibacterial
Effect, can be extensive as early as possible under the action of the effective component of antibiotic layer when the diffusate of wound surface is after moisture absorption layer absorbs
It is multiple, it avoids after antibiotic layer absorbs moisture and solidifies the case where being hardened, antibacterial anti hemorrhagic significant effect.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of the embodiment of the present invention 1.
In figure: 1- moisture absorption layer, 2- outer layer, 3- antibiotic layer, 4- circular hole.
Specific embodiment
The invention will be further described combined with specific embodiments below.
Embodiment 1
A kind of anesthesia surgery hemostatic and antibacterial auxiliary material, as shown in Figure 1, include the moisture absorption layer 1 and outer layer 2 being arranged from inside to outside, wherein
Multiple circular holes 4 are uniformly arranged on moisture absorption layer 1, circular hole 4 is interior and antibiotic layer 3 is arranged in 1 outer surface of moisture absorption layer, and the outer layer 2 is 3 layers
Cotton fiber cloth；
Wherein moisture absorption layer 1 is prepared from the following raw materials in parts by weight: 90 parts of acrylic acid, N, 3 parts of N- methylene-bisacrylamide, swollen
5 parts of profit soil, 12 parts of polyvinyl alcohol, 5 parts of polymer alumina, 4 parts of glycerol and 0.1 part of initiator.
Antibiotic layer 3 is prepared from the following raw materials in parts by weight: 45 parts of cotton fiber, 3 parts of nano zine oxide, 25 parts of Radix Notoginseng, big
35 parts of Ji, 25 parts of cattail pollen and 25 parts of folium isatidis.
Wherein initiator is sodium peroxydisulfate.
Moisture absorption layer is made of following steps: 1 times of water dissolution being added in acrylic acid, potassium hydroxide dissolution is added dropwise under condition of ice bath
Neutralization reaction is carried out, degree of neutralization 60% sequentially adds polyvinyl alcohol, bentonite, polymer alumina, glycerol, crosslinking agent under stirring
N, N- methylene-bisacrylamide and initiator continue to stir 15min, be subsequently poured into mold, stand 100 DEG C of drying after 3h.
Anesthesia surgery hemostatic and antibacterial auxiliary material, is made of following steps:
1) in a solvent, ultrasonic mixing 40min obtains the cotton spinning solution that mass fraction is 1.5%, and solvent is for cotton fiber dissolution
DMAC/LiCl mixed solvent, wherein DMAC/LiCl weight ratio is 9:1；
2) will Radix Notoginseng, setose thistle, cattail pollen and folium isatidis mix after 6 times of volume fractions are added is 80% ethanol solution, refluxing extraction 2h,
Combined extract, being concentrated into relative density is 1.3, obtains herb liquid；
3) moisture absorption layer is cut into circular hole, and herb liquid, nano zine oxide are added in cotton spinning solution and are stirred evenly, then in moisture absorption layer
Upper carry out electrostatic spinning, wherein spinning distance is 10cm, voltage 20Kv, extruded velocity 5ml/h, forms antibiotic layer 3, then
Cotton fiber cloth is bonded in 3 outside of antibiotic layer, obtains product.
Embodiment 2
A kind of anesthesia surgery hemostatic and antibacterial auxiliary material, structure is same as Example 1, the difference is that:
Outer layer 2 is 2 layers of bamboo charcoal fiber cloth；
Wherein moisture absorption layer 1 is prepared from the following raw materials in parts by weight: 92 parts of acrylic acid, N, 3.5 parts of N- methylene-bisacrylamide,
5.2 parts of bentonite, 12 parts of polyvinyl alcohol, 6 parts of polymer alumina, 4.5 parts of glycerol and 0.15 part of initiator.
Antibiotic layer 3 is prepared from the following raw materials in parts by weight: 46 parts of cotton fiber, 2.8 parts of nano zine oxide, 26 parts of Radix Notoginseng,
32 parts of setose thistle, 26 parts of cattail pollen and 26 parts of folium isatidis.
Wherein initiator is sodium peroxydisulfate.
Moisture absorption layer is made of following steps: 1 times of water dissolution being added in acrylic acid, potassium hydroxide dissolution is added dropwise under condition of ice bath
Neutralization reaction is carried out, degree of neutralization 60% sequentially adds polyvinyl alcohol, bentonite, polymer alumina, glycerol, crosslinking agent under stirring
N, N- methylene-bisacrylamide and initiator continue to stir 16min, be subsequently poured into mold, 100 DEG C of drying after 3h.
Anesthesia surgery hemostatic and antibacterial auxiliary material, is made of following steps:
1) in a solvent, ultrasonic mixing 40min obtains cotton spinning solution, and solvent is DMAC/LiCl mixed solvent for cotton fiber dissolution,
Wherein DMAC/LiCl weight ratio is 9:1；
2) it is 80% ethanol solution, refluxing extraction that 7 times of volume fractions are added after mixing Radix Notoginseng, setose thistle, cattail pollen and folium isatidis
2.5h, combined extract, being concentrated into relative density is 1.3, obtains herb liquid；
3) moisture absorption layer is cut into circular hole, and herb liquid, nano zine oxide are added in cotton spinning solution and are stirred evenly, then in moisture absorption layer
Upper carry out electrostatic spinning forms antibiotic layer 3, and bamboo charcoal fiber cloth is then bonded in 3 outside of antibiotic layer, obtains product.
Embodiment 3
A kind of anesthesia surgery hemostatic and antibacterial auxiliary material, structure is same as Example 1, the difference is that:
Outer layer 2 is 3 layers of cotton fiber cloth；
Wherein moisture absorption layer 1 is prepared from the following raw materials in parts by weight: 94 parts of acrylic acid, N, 4 parts of N- methylene-bisacrylamide, swollen
5.4 parts of profit soil, 11 parts of polyvinyl alcohol, 7 parts of polymer alumina, 5 parts of glycerol and 0.2 part of initiator.
Antibiotic layer 3 is prepared from the following raw materials in parts by weight: 48 parts of cotton fiber, 2.5 parts of nano zine oxide, 28 parts of Radix Notoginseng,
30 parts of setose thistle, 28 parts of cattail pollen and 28 parts of folium isatidis.
Wherein initiator is potassium peroxydisulfate.
Moisture absorption layer is made of following steps: 1.2 times of water dissolutions being added in acrylic acid, it is molten that potassium hydroxide is added dropwise under condition of ice bath
Solution carries out neutralization reaction, and degree of neutralization 65% sequentially adds polyvinyl alcohol, bentonite, polymer alumina, glycerol, crosslinking under stirring
Agent N, N- methylene-bisacrylamide and initiator continue to stir 17min, be subsequently poured into mold, 100 DEG C of drying after 3.5h.
Anesthesia surgery hemostatic and antibacterial auxiliary material, is made of following steps:
1) in a solvent, ultrasonic mixing 50min obtains cotton spinning solution, and solvent is DMAC/LiCl mixed solvent for cotton fiber dissolution,
Wherein DMAC/LiCl weight ratio is 9:1；
2) will Radix Notoginseng, setose thistle, cattail pollen and folium isatidis mix after 8 times of volume fractions are added is 80% ethanol solution, refluxing extraction 3h,
Combined extract, being concentrated into relative density is 1.4, obtains herb liquid；
3) moisture absorption layer is cut into circular hole, and herb liquid, nano zine oxide are added in cotton spinning solution and are stirred evenly, then in moisture absorption layer
Upper carry out electrostatic spinning forms antibiotic layer 3, and cotton fiber cloth is then bonded in 3 outside of antibiotic layer, obtains product.
Embodiment 4
A kind of anesthesia surgery hemostatic and antibacterial auxiliary material, structure is same as Example 1, the difference is that:
Moisture absorption layer 1 is prepared from the following raw materials in parts by weight: 95 parts of acrylic acid, N, 4 parts of N- methylene-bisacrylamide, bentonite
5.5 parts, 11 parts of polyvinyl alcohol, 7 parts of polymer alumina, 5 parts of glycerol and 0.2 part of initiator.
Antibiotic layer 3 is prepared from the following raw materials in parts by weight: 50 parts of cotton fiber, 2.4 parts of nano zine oxide, 30 parts of Radix Notoginseng,
28 parts of setose thistle, 30 parts of cattail pollen and 30 parts of folium isatidis.
Wherein initiator is potassium peroxydisulfate.
Moisture absorption layer is made of following steps: 1.2 times of water dissolutions being added in acrylic acid, it is molten that potassium hydroxide is added dropwise under condition of ice bath
Solution carries out neutralization reaction, and degree of neutralization 65% sequentially adds polyvinyl alcohol, bentonite, polymer alumina, glycerol, crosslinking under stirring
Agent N, N- methylene-bisacrylamide and initiator continue to stir 18min, be subsequently poured into mold, 100 DEG C of drying after 3.5h.
Anesthesia surgery hemostatic and antibacterial auxiliary material, is made of following steps:
1) in a solvent, ultrasonic mixing 50min obtains cotton spinning solution, and solvent is DMAC/LiCl mixed solvent for cotton fiber dissolution,
Wherein DMAC/LiCl weight ratio is 9:1；
2) it is 80% ethanol solution, refluxing extraction that 7 times of volume fractions are added after mixing Radix Notoginseng, setose thistle, cattail pollen and folium isatidis
2.5h, combined extract, being concentrated into relative density is 1.4, obtains herb liquid；
3) moisture absorption layer is cut into circular hole, and herb liquid, nano zine oxide are added in cotton spinning solution and are stirred evenly, then in moisture absorption layer
Upper carry out electrostatic spinning forms antibiotic layer 3, and cotton fiber cloth is then bonded in 3 outside of antibiotic layer, obtains product.
Embodiment 5
A kind of anesthesia surgery hemostatic and antibacterial auxiliary material, structure is same as Example 1, the difference is that:
Wherein moisture absorption layer 1 is prepared from the following raw materials in parts by weight: 96 parts of acrylic acid, N, 4.5 parts of N- methylene-bisacrylamide,
5.6 parts of bentonite, 10 parts of polyvinyl alcohol, 8 parts of polymer alumina, 5.5 parts of glycerol and 0.25 part of initiator.
Antibiotic layer 3 is prepared from the following raw materials in parts by weight: 52 parts of cotton fiber, 2.2 parts of nano zine oxide, 32 parts of Radix Notoginseng,
26 parts of setose thistle, 32 parts of cattail pollen and 32 parts of folium isatidis.
Wherein initiator is sodium peroxydisulfate.
Moisture absorption layer is made of following steps: 1.4 times of water dissolutions being added in acrylic acid, it is molten that potassium hydroxide is added dropwise under condition of ice bath
Solution carries out neutralization reaction, and degree of neutralization 70% sequentially adds polyvinyl alcohol, bentonite, polymer alumina, glycerol, crosslinking under stirring
Agent N, N- methylene-bisacrylamide and initiator continue to stir 19min, be subsequently poured into mold, 100 DEG C of drying after 4h.
Anesthesia surgery hemostatic and antibacterial auxiliary material, is made of following steps:
1) in a solvent, ultrasonic mixing 55min obtains cotton spinning solution, and solvent is DMAC/LiCl mixed solvent for cotton fiber dissolution,
Wherein DMAC/LiCl weight ratio is 9:1；
2) will Radix Notoginseng, setose thistle, cattail pollen and folium isatidis mix after 6 times of volume fractions are added is 80% ethanol solution, refluxing extraction 2h,
Combined extract, being concentrated into relative density is 1.5, obtains herb liquid；
3) moisture absorption layer is cut into circular hole, and herb liquid, nano zine oxide are added in cotton spinning solution and are stirred evenly, then in moisture absorption layer
Upper carry out electrostatic spinning forms antibiotic layer 3, and cotton fiber cloth is then bonded in 3 outside of antibiotic layer, obtains product.
Embodiment 6
A kind of anesthesia surgery hemostatic and antibacterial auxiliary material, structure is same as Example 1, the difference is that:
Wherein moisture absorption layer 1 is prepared from the following raw materials in parts by weight: 98 parts of acrylic acid, N, 5 parts of N- methylene-bisacrylamide, swollen
5.8 parts of profit soil, 10 parts of polyvinyl alcohol, 5 parts of polymer alumina, 6 parts of glycerol and 0.3 part of initiator.
Antibiotic layer 3 is prepared from the following raw materials in parts by weight: 54 parts of cotton fiber, 2.0 parts of nano zine oxide, 34 parts of Radix Notoginseng,
25 parts of setose thistle, 34 parts of cattail pollen and 34 parts of folium isatidis.
Wherein initiator is sodium peroxydisulfate.
Moisture absorption layer is made of following steps: 1.5 times of water dissolutions being added in acrylic acid, it is molten that potassium hydroxide is added dropwise under condition of ice bath
Solution carries out neutralization reaction, and degree of neutralization 70% sequentially adds polyvinyl alcohol, bentonite, polymer alumina, glycerol, crosslinking under stirring
Agent N, N- methylene-bisacrylamide and initiator continue to stir 20min, be subsequently poured into mold, 100 DEG C of drying after 4h.
Anesthesia surgery hemostatic and antibacterial auxiliary material, is made of following steps:
1) in a solvent, ultrasonic mixing 60min obtains cotton spinning solution, and solvent is DMAC/LiCl mixed solvent for cotton fiber dissolution,
Wherein DMAC/LiCl weight ratio is 9:1；
2) will Radix Notoginseng, setose thistle, cattail pollen and folium isatidis mix after 7 times of volume fractions are added is 80% ethanol solution, refluxing extraction 3h,
Combined extract, being concentrated into relative density is 1.3, obtains herb liquid；
3) moisture absorption layer is cut into circular hole, and herb liquid, nano zine oxide are added in cotton spinning solution and are stirred evenly, then in moisture absorption layer
Upper carry out electrostatic spinning forms antibiotic layer 3, and cotton fiber cloth is then bonded in 3 outside of antibiotic layer, obtains product.
Embodiment 7
A kind of anesthesia surgery hemostatic and antibacterial auxiliary material, structure is same as Example 1, the difference is that:
Moisture absorption layer 1 is prepared from the following raw materials in parts by weight: 100 parts of acrylic acid, N, 3 parts of N- methylene-bisacrylamide, swelling
6 parts of soil, 12 parts of polyvinyl alcohol, 6 parts of polymer alumina, 4 parts of glycerol and 0.25 part of initiator.
Antibiotic layer 3 is prepared from the following raw materials in parts by weight: 55 parts of cotton fiber, 2.5 parts of nano zine oxide, 35 parts of Radix Notoginseng,
30 parts of setose thistle, 35 parts of cattail pollen and 35 parts of folium isatidis.
Wherein initiator is potassium peroxydisulfate.
Moisture absorption layer is made of following steps: 1.5 times of water dissolutions being added in acrylic acid, it is molten that potassium hydroxide is added dropwise under condition of ice bath
Solution carries out neutralization reaction, and degree of neutralization 65% sequentially adds polyvinyl alcohol, bentonite, polymer alumina, glycerol, crosslinking under stirring
Agent N, N- methylene-bisacrylamide and initiator continue to stir 15min, be subsequently poured into mold, 100 DEG C of drying after 3.5h.
Anesthesia surgery hemostatic and antibacterial auxiliary material, is made of following steps:
1) in a solvent, ultrasonic mixing 60min obtains cotton spinning solution, and solvent is DMAC/LiCl mixed solvent for cotton fiber dissolution,
Wherein DMAC/LiCl weight ratio is 9:1；
2) it is 80% ethanol solution, refluxing extraction that 8 times of volume fractions are added after mixing Radix Notoginseng, setose thistle, cattail pollen and folium isatidis
2.5h, combined extract, being concentrated into relative density is 1.4, obtains herb liquid；
3) moisture absorption layer is cut into circular hole, and herb liquid, nano zine oxide are added in cotton spinning solution and are stirred evenly, then in moisture absorption layer
Upper carry out electrostatic spinning forms antibiotic layer 3, and cotton fiber cloth is then bonded in 3 outside of antibiotic layer, obtains product.
Embodiment 8
A kind of anesthesia surgery hemostatic and antibacterial auxiliary material, structure is same as Example 1, the difference is that:
Moisture absorption layer 1 is prepared from the following raw materials in parts by weight: 90 parts of acrylic acid, N, 4 parts of N- methylene-bisacrylamide, bentonite
5.5 parts, 12 parts of polyvinyl alcohol, 7 parts of polymer alumina, 5 parts of glycerol and 0.3 part of initiator.
Antibiotic layer 3 is prepared from the following raw materials in parts by weight: 50 parts of cotton fiber, 2.5 parts of nano zine oxide, 30 parts of Radix Notoginseng,
25 parts of setose thistle, 30 parts of cattail pollen and 25 parts of folium isatidis.
Wherein initiator is potassium peroxydisulfate.
Moisture absorption layer is made of following steps: 1.5 times of water dissolutions being added in acrylic acid, it is molten that potassium hydroxide is added dropwise under condition of ice bath
Solution carries out neutralization reaction, and degree of neutralization 70% sequentially adds polyvinyl alcohol, bentonite, polymer alumina, glycerol, crosslinking under stirring
Agent N, N- methylene-bisacrylamide and initiator continue to stir 16min, be subsequently poured into mold, 100 DEG C of drying after 3h.
Anesthesia surgery hemostatic and antibacterial auxiliary material, is made of following steps:
1) in a solvent, ultrasonic mixing 60min obtains cotton spinning solution, and solvent is DMAC/LiCl mixed solvent for cotton fiber dissolution,
Wherein DMAC/LiCl weight ratio is 9:1；
2) will Radix Notoginseng, setose thistle, cattail pollen and folium isatidis mix after 6 times of volume fractions are added is 80% ethanol solution, refluxing extraction 3h,
Combined extract, being concentrated into relative density is 1.1, obtains herb liquid；
3) moisture absorption layer is cut into circular hole, and herb liquid, nano zine oxide are added in cotton spinning solution and are stirred evenly, then in moisture absorption layer
Upper carry out electrostatic spinning forms antibiotic layer 3, and cotton fiber cloth is then bonded in 3 outside of antibiotic layer, obtains product.
Comparative example 1
Comparative example 1 is substantially the same manner as Example 8, the difference is that: polyvinyl alcohol is replaced with acrylic acid by comparative example 1, other
Technique and formula are same as Example 8.
Comparative example 2
Comparative example 2 is substantially the same manner as Example 8, the difference is that: comparative example 2 removes bentonite and glycerol, other techniques with
And formula is same as Example 8
Performance detection
The moisture absorption layer for taking 1-8 of the embodiment of the present invention and documents 1-2 to prepare, tests its water suction according to GB/T22905-2008
Amount and moisture-holding capacity, the results are shown in Table 1.
1 embodiment 1-8 of table and the test of documents 1-2 moisture pick-up properties
As can be seen from Table 1, the water absorbency and water retentivity of the moisture absorption layer of 1-8 of embodiment of the present invention preparation can be excellent, is conducive to hurt
The recovery as early as possible of mouth, in addition comparative example 1 and 2 is to be adjusted on the basis of embodiment 8 to the composition of moisture absorption layer, water imbibition
It can substantially reduce, illustrate that adding polyvinyl alcohol, glycerol and bentonite in water absorption layer can increase the water absorbing properties of the application.
Finally, it is stated that the above examples are only used to illustrate the technical scheme of the present invention and are not limiting, this field is common
Other modifications or equivalent replacement that technical staff makes technical solution of the present invention, without departing from technical solution of the present invention
Spirit and scope, be intended to be within the scope of the claims of the invention.
Claims (6)
1. a kind of anesthesia surgery hemostatic and antibacterial auxiliary material, it is characterised in that: including the moisture absorption layer (1) being arranged from inside to outside and outer layer
(2), it is uniformly arranged multiple circular holes (4) on the moisture absorption layer (1), the setting of in the circular hole (4) and moisture absorption layer (1) outer surface is anti-
Bacterium layer (3), the outer layer (2) are cotton fiber or bamboo charcoal fiber；
The moisture absorption layer (1) is prepared from the following raw materials in parts by weight: 90-100 parts of acrylic acid, N, N- methylene-bisacrylamide
3-5 parts, 5-6 parts of bentonite, 10-12 parts of polyvinyl alcohol, 5-8 parts of polymer alumina, 4-6 parts of glycerol and 0.1-0.3 parts of initiator.
2. a kind of anesthesia surgery hemostatic and antibacterial auxiliary material according to claim 1, it is characterised in that: the antibiotic layer (3) by
The raw material of following parts by weight is made: 45-55 parts of cotton fiber, 2-3 parts of nano zine oxide, 25-35 parts of Radix Notoginseng, 25-35 parts of setose thistle,
25-35 parts and folium isatidis 25-35 parts of cattail pollen.
3. a kind of anesthesia surgery hemostatic and antibacterial auxiliary material according to claim 1, it is characterised in that: the initiator is over cure
Sour sodium or potassium peroxydisulfate.
4. a kind of anesthesia surgery hemostatic and antibacterial auxiliary material according to claim 1, it is characterised in that: the moisture absorption layer is by following
Step is made: 1-1.5 times of water dissolution is added in acrylic acid, potassium hydroxide dissolution is added dropwise under condition of ice bath and carries out neutralization reaction, in
It is 60-70% with degree, polyvinyl alcohol, bentonite, polymer alumina, glycerol, crosslinking agent N, N- di-2-ethylhexylphosphine oxide is sequentially added under stirring
Acrylamide and initiator continue to stir 15-20min, be subsequently poured into mold, stand 100 DEG C of drying after 3-4h.
5. a kind of anesthesia surgery hemostatic and antibacterial auxiliary material according to claim 1, it is characterised in that: be made of following steps:
1) in a solvent, ultrasonic mixing 40-60min obtains cotton spinning solution for cotton fiber dissolution；
2) it is 80% ethanol solution, refluxing extraction 2- that 6-8 times of volume fraction is added after mixing Radix Notoginseng, setose thistle, cattail pollen and folium isatidis
3h, combined extract, being concentrated into relative density is 1.3-1.5, obtains herb liquid；
3) moisture absorption layer is cut into circular hole, and herb liquid, nano zine oxide are added in cotton spinning solution and are stirred evenly, then in moisture absorption layer
Upper carry out electrostatic spinning is formed antibiotic layer (3), then must produce cotton fiber or bamboo charcoal fiber setting on the outside of antibiotic layer (3)
Product.
6. a kind of anesthesia surgery hemostatic and antibacterial auxiliary material according to claim 5, it is characterised in that: in the step (1)
Solvent is DMAC/LiCl mixed solvent.
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| CN106975095A (en) * | 2017-04-11 | 2017-07-25 | 南阳师范学院 | A kind of antibacterial medical auxiliary material and preparation method thereof |
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| CN206508116U (en) * | 2016-08-16 | 2017-09-22 | 广东泰宝医疗科技股份有限公司 | A kind of dressing of hemorrhoid Postoperative Dressing |
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| CN2292547Y (en) * | 1997-04-18 | 1998-09-30 | 天津京海综合经营服务部塘沽科学技术研究所 | Medical hygroscopic dressing capable of no sticking wound |
| CN2319040Y (en) * | 1997-12-09 | 1999-05-19 | 陶莉莉 | Chinese medicine filling dressing |
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