CN108939126A - A kind of medical bandage of aqueous gel antibiotic layer - Google Patents
A kind of medical bandage of aqueous gel antibiotic layer Download PDFInfo
- Publication number
- CN108939126A CN108939126A CN201810731442.1A CN201810731442A CN108939126A CN 108939126 A CN108939126 A CN 108939126A CN 201810731442 A CN201810731442 A CN 201810731442A CN 108939126 A CN108939126 A CN 108939126A
- Authority
- CN
- China
- Prior art keywords
- layer
- bamboo charcoal
- solution
- added
- hydrogel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000003115 biocidal effect Effects 0.000 title claims abstract description 27
- 235000017166 Bambusa arundinacea Nutrition 0.000 claims abstract description 30
- 235000017491 Bambusa tulda Nutrition 0.000 claims abstract description 30
- 241001330002 Bambuseae Species 0.000 claims abstract description 30
- 235000015334 Phyllostachys viridis Nutrition 0.000 claims abstract description 30
- 239000011425 bamboo Substances 0.000 claims abstract description 30
- 239000003610 charcoal Substances 0.000 claims abstract description 30
- 239000000835 fiber Substances 0.000 claims abstract description 30
- 239000000499 gel Substances 0.000 claims abstract description 23
- 239000000017 hydrogel Substances 0.000 claims abstract description 19
- YBHILYKTIRIUTE-UHFFFAOYSA-N berberine Chemical compound C1=C2CC[N+]3=CC4=C(OC)C(OC)=CC=C4C=C3C2=CC2=C1OCO2 YBHILYKTIRIUTE-UHFFFAOYSA-N 0.000 claims abstract description 11
- 229940093265 berberine Drugs 0.000 claims abstract description 11
- QISXPYZVZJBNDM-UHFFFAOYSA-N berberine Natural products COc1ccc2C=C3N(Cc2c1OC)C=Cc4cc5OCOc5cc34 QISXPYZVZJBNDM-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000004744 fabric Substances 0.000 claims abstract description 11
- 238000012986 modification Methods 0.000 claims abstract description 8
- 230000004048 modification Effects 0.000 claims abstract description 8
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract description 7
- 210000002615 epidermis Anatomy 0.000 claims abstract description 7
- 229910021389 graphene Inorganic materials 0.000 claims abstract description 7
- 210000003491 skin Anatomy 0.000 claims abstract description 7
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims abstract description 3
- 239000010410 layer Substances 0.000 claims description 70
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 30
- ROOXNKNUYICQNP-UHFFFAOYSA-N ammonium persulfate Chemical compound [NH4+].[NH4+].[O-]S(=O)(=O)OOS([O-])(=O)=O ROOXNKNUYICQNP-UHFFFAOYSA-N 0.000 claims description 30
- 238000003756 stirring Methods 0.000 claims description 23
- 238000000034 method Methods 0.000 claims description 20
- 229910001870 ammonium persulfate Inorganic materials 0.000 claims description 15
- 238000009987 spinning Methods 0.000 claims description 15
- 229920001661 Chitosan Polymers 0.000 claims description 14
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 claims description 13
- 229910000077 silane Inorganic materials 0.000 claims description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 229920002752 Konjac Polymers 0.000 claims description 10
- 238000009210 therapy by ultrasound Methods 0.000 claims description 10
- LUEWUZLMQUOBSB-FSKGGBMCSA-N (2s,3s,4s,5s,6r)-2-[(2r,3s,4r,5r,6s)-6-[(2r,3s,4r,5s,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5s,6r)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](O[C@@H](OC3[C@H](O[C@@H](O)[C@@H](O)[C@H]3O)CO)[C@@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O LUEWUZLMQUOBSB-FSKGGBMCSA-N 0.000 claims description 8
- 244000247812 Amorphophallus rivieri Species 0.000 claims description 8
- 235000001206 Amorphophallus rivieri Nutrition 0.000 claims description 8
- 229920002581 Glucomannan Polymers 0.000 claims description 8
- 229940046240 glucomannan Drugs 0.000 claims description 8
- 235000010485 konjac Nutrition 0.000 claims description 8
- 239000000252 konjac Substances 0.000 claims description 8
- 238000001816 cooling Methods 0.000 claims description 5
- 238000010041 electrostatic spinning Methods 0.000 claims description 5
- ZIUHHBKFKCYYJD-UHFFFAOYSA-N n,n'-methylenebisacrylamide Chemical compound C=CC(=O)NCNC(=O)C=C ZIUHHBKFKCYYJD-UHFFFAOYSA-N 0.000 claims description 5
- 239000012299 nitrogen atmosphere Substances 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 5
- 239000003755 preservative agent Substances 0.000 claims description 5
- 230000002335 preservative effect Effects 0.000 claims description 5
- 239000002994 raw material Substances 0.000 claims description 5
- 239000011347 resin Substances 0.000 claims description 5
- 229920005989 resin Polymers 0.000 claims description 5
- 239000002344 surface layer Substances 0.000 claims description 5
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N titanium dioxide Inorganic materials O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 claims description 5
- 238000005406 washing Methods 0.000 claims description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
- 239000006087 Silane Coupling Agent Substances 0.000 claims description 2
- 239000012153 distilled water Substances 0.000 claims description 2
- 239000003292 glue Substances 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 10
- 208000027418 Wounds and injury Diseases 0.000 abstract description 8
- 230000035699 permeability Effects 0.000 abstract description 8
- 206010052428 Wound Diseases 0.000 abstract description 6
- 230000000694 effects Effects 0.000 abstract description 5
- 206010061218 Inflammation Diseases 0.000 abstract description 2
- 206010048038 Wound infection Diseases 0.000 abstract description 2
- 230000003110 anti-inflammatory effect Effects 0.000 abstract description 2
- 230000004054 inflammatory process Effects 0.000 abstract description 2
- SOQBVABWOPYFQZ-UHFFFAOYSA-N oxygen(2-);titanium(4+) Chemical compound [O-2].[O-2].[Ti+4] SOQBVABWOPYFQZ-UHFFFAOYSA-N 0.000 abstract description 2
- 230000001954 sterilising effect Effects 0.000 abstract description 2
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 2
- 239000000758 substrate Substances 0.000 abstract description 2
- 230000002195 synergetic effect Effects 0.000 abstract 1
- 230000000052 comparative effect Effects 0.000 description 8
- 238000012360 testing method Methods 0.000 description 5
- 229920000742 Cotton Polymers 0.000 description 3
- 230000001476 alcoholic effect Effects 0.000 description 3
- 230000009172 bursting Effects 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 230000000845 anti-microbial effect Effects 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 241000222122 Candida albicans Species 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000590002 Helicobacter pylori Species 0.000 description 1
- 229920000297 Rayon Polymers 0.000 description 1
- 206010072170 Skin wound Diseases 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 229940023064 escherichia coli Drugs 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 229940037467 helicobacter pylori Drugs 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/00987—Apparatus or processes for manufacturing non-adhesive dressings or bandages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/01—Non-adhesive bandages or dressings
- A61F13/01021—Non-adhesive bandages or dressings characterised by the structure of the dressing
- A61F13/01029—Non-adhesive bandages or dressings characterised by the structure of the dressing made of multiple layers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/216—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with other specific functional groups, e.g. aldehydes, ketones, phenols, quaternary phosphonium groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Materials Engineering (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Inorganic Chemistry (AREA)
- Manufacturing & Machinery (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Materials For Medical Uses (AREA)
Abstract
The invention discloses a kind of medical bandage of aqueous gel antibiotic layer, which contains three layers altogether, and layer is made using hydrogel, is bonded skin, has sterilization, the effect of drier wounds;Middle layer contains modification bamboo charcoal fiber, has good gas permeability, improves patient's usage comfort, and with hydrogel layer synergy, antibacterial effect is excellent;Upper epidermis is medical pressure sensitive adhesive, facilitates fitting, avoids the puzzlement of knotting bring.Berberine, Aloe Vera Gel is added in hydrogel layer, improves the effect of the antibacterial anti-inflammatory of hydrogel, effectively prevent wound infection inflammation;Bamboo charcoal fiber is modified using nano-titanium dioxide, graphene oxide, on the one hand enhances the compatibility of bamboo charcoal fiber Yu base fabric substrate, enhances its mechanical property and steam permeability, on the other hand, synergistic with hydrogel antibiotic layer, antibacterial, keeps antibacterial effect significant from inside to outside.
Description
Technical field
The invention belongs to medical bandage technical fields, and in particular to a kind of medical bandage of aqueous gel antibiotic layer.
Background technique
Bandage is the gauze belt at place or affected part of binding up a wound, usually to fixed and protect the material of operation or injury
Material, it is widely used.Simple list canopy band, is made of gauze or cotton, is suitable for four limbs, tail portion, head and thorax abdomen, now
Commercially available bandage has 100% cotton plain weave, wrinkle elastoplast, ammonia human relations elastoplast, PBT elastoplast and cotton gauze selvedge
Bandage, viscose plaster bandage etc..Bandage is surgical operation institute necessary article, and the necessary article of medical treatment.
Bandage development at present is improved mainly around base fabric, including base fabric uses single-coated foam, elastic force base fabric etc..However
It after handling wound, is directly contacted between bandage and skin wound, wound is nearby usually with the presence of spillage, in addition bandage is usually saturating
Gas performance is poor, is easy to happen bacterium infection.Huge pain is brought to injury, is unfavorable for the healing of wound.
Summary of the invention
In view of the above-mentioned problems, the present invention is intended to provide a kind of medical bandage of aqueous gel antibiotic layer, antibacterial effect are good
It is good, and comfort level greatly improves.
The invention is realized by the following technical scheme:
A kind of medical bandage of aqueous gel antibiotic layer, including middle layer and the upper surface layer for being located at middle layer two sides under
Superficial layer, which is characterized in that layer is hydrogel antibiotic layer, is made of raw material from the following weight: konjac glucomannan 10-20, shell
Glycan 10-20, berberine 0.2-0.3, ammonium persulfate solution 5-10, N, N'- methylene-bisacrylamide 5-10.
The ammonium persulfate solution mass concentration is 4-8%.
Further, the layer the preparation method comprises the following steps:
(1) chitosan is dissolved in the acetic acid of 2-5%, the chitosan solution that mass concentration is 2-3% is made, konjaku is then added
Glue, berberine, Aloe Vera Gel, the stirring and dissolving 40-80min under 50-70 DEG C, 300-400rpm, are added ammonium persulfate while stirring
After stirring 15-30min, N is added in solution, and N'- methylene-bisacrylamide continues to stir 30-50min, is then allowed to stand 1-2h,
Obtain spinning solution;
(2) method of electrostatic spinning is utilized, spinning forms a film on the middle layer by spinning solution obtained by step (1), then by gains
Preservative film is covered, is placed in 55-65 DEG C of environment and stands 5-10h.
Further, middle layer is the base cloth layer of the fiber containing modification bamboo charcoal, and bamboo charcoal fiber method of modifying is as follows:
(1) it in the acetic acid solution for the 2-5% that 5-10 parts of bamboo charcoal fibers are added to 5-10 times of its volume, is stirred under 800-1000rpm
20-30min is handled, is then filtered, is distilled water washing 3-5 times, it is 5-10% that water content is dried at 50-70 DEG C;
(2) 3-5 parts of nano-titanium dioxides, 1-2 parts of graphene oxides are put into ball mill and are sufficiently mixed uniformly, then existed
130-150 DEG C of vacuum oven handles 4-6h in nitrogen atmosphere, the silane coupling agent of 10-15 times of its volume is added after cooling
In solution, at 30-40 DEG C, using ultrasonic treatment 20-30min, bamboo charcoal fiber is then added, continues with 30-60min, mistake
Filter, gains are put into microwave device, 20-30s is handled under 500-800W, is sent in vaporium after taking-up, steam 30-
40min is then dry at 60-70 DEG C.
Further, upper epidermis is medical pressure-sensing glue-line.
Further, in use, hydrogel antibiotic layer is made to be bonded skin.
Further, step (2) the silane coupler solution mass concentration is the silane resin acceptor kh-550 of 3-10%
Ethanol solution.
Further, step (2) the ultrasonic treatment condition is 80-100Hz.
Beneficial effects of the present invention: medical bandage prepared by the present invention contains three layers altogether, and layer is made using hydrogel, patch
Skin is closed, there is sterilization, the effect of drier wounds;Middle layer contains modification bamboo charcoal fiber, has good gas permeability, improves and suffers from
Person's usage comfort, with hydrogel layer synergy, antibacterial effect is excellent;Upper epidermis is medical pressure sensitive adhesive, facilitates fitting, avoids
The puzzlement of knotting bring.Berberine, Aloe Vera Gel is added in hydrogel layer, improves the effect of the antibacterial anti-inflammatory of hydrogel, has
Effect prevents wound infection inflammation;Bamboo charcoal fiber is modified using nano-titanium dioxide, graphene oxide, is on the one hand enhanced
The compatibility of bamboo charcoal fiber and base fabric substrate enhances its mechanical property and steam permeability, on the other hand, cooperates with hydrogel antibiotic layer
Synergy, antibacterial, keeps antibacterial effect significant from inside to outside.
Specific embodiment
Illustrate the present invention with specific embodiment below, but is not limitation of the present invention.
Embodiment 1
A kind of medical bandage of aqueous gel antibiotic layer, including middle layer and the upper surface layer for being located at middle layer two sides under
Superficial layer, which is characterized in that layer is hydrogel antibiotic layer, is made of raw material from the following weight: konjac glucomannan 10, chitosan
10, berberine 0.2, ammonium persulfate solution 5, N, N'- methylene-bisacrylamide 5.
The ammonium persulfate solution mass concentration is 4%.
Further, the layer the preparation method comprises the following steps:
(1) chitosan is dissolved in 2% acetic acid, the chitosan solution that mass concentration is 2% is made, konjac glucomannan, Huang is then added
Ammonium persulfate solution is added at 50 DEG C, stirring and dissolving 40min under 300rpm in Lian Su, Aloe Vera Gel while stirring, stirs 15min
Afterwards, N is added, N'- methylene-bisacrylamide continues to stir 30min, is then allowed to stand 1h, obtains spinning solution;
(2) method of electrostatic spinning is utilized, spinning forms a film on the middle layer by spinning solution obtained by step (1), then by gains
Preservative film is covered, is placed in 55 DEG C of environment and stands 5h.
Further, middle layer is the base cloth layer of the fiber containing modification bamboo charcoal, and bamboo charcoal fiber method of modifying is as follows:
(1) 5 parts of bamboo charcoal fibers are added in 2% acetic acid solution of 5 times of its volume, stir process 20min under 800rpm, so
After filter, distill water washing 3 times, be dried at 50 DEG C water content be 5%;
(2) 3 parts of nano-titanium dioxides, 1 part of graphene oxide are put into ball mill and are sufficiently mixed uniformly, then 130
DEG C vacuum oven, 4h is handled in nitrogen atmosphere, is added in the silane coupler solution of 10 times of its volume after cooling, at 30 DEG C
Under, using ultrasonic treatment 20min, bamboo charcoal fiber is then added, continues with 30min, filters, gains are put into microwave device
In, 20s is handled under 500W, is sent in vaporium after taking-up, and 30min is steamed, it is then dry at 60 DEG C.
Further, upper epidermis is medical pressure-sensing glue-line.
Further, in use, hydrogel antibiotic layer is made to be bonded skin.
Further, the second for the silane resin acceptor kh-550 that step (2) the silane coupler solution mass concentration is 3%
Alcoholic solution.
Further, step (2) the ultrasonic treatment condition is 80Hz.
Embodiment 2
A kind of medical bandage of aqueous gel antibiotic layer, including middle layer and the upper surface layer for being located at middle layer two sides under
Superficial layer, which is characterized in that layer is hydrogel antibiotic layer, is made of raw material from the following weight: konjac glucomannan 15, chitosan
15, berberine 0.2, ammonium persulfate solution 8, N, N'- methylene-bisacrylamide 7.
The ammonium persulfate solution mass concentration is 6%.
Further, the layer the preparation method comprises the following steps:
(1) chitosan is dissolved in 3% acetic acid, be made mass concentration be 2-3% chitosan solution, then be added konjac glucomannan,
Ammonium persulfate solution is added at 60 DEG C, stirring and dissolving 60min under 350rpm in berberine, Aloe Vera Gel while stirring, stirs 20min
Afterwards, N is added, N'- methylene-bisacrylamide continues to stir 40min, is then allowed to stand 2h, obtains spinning solution;
(2) method of electrostatic spinning is utilized, spinning forms a film on the middle layer by spinning solution obtained by step (1), then by gains
Preservative film is covered, is placed in 60 DEG C of environment and stands 8h.
Further, middle layer is the base cloth layer of the fiber containing modification bamboo charcoal, and bamboo charcoal fiber method of modifying is as follows:
(1) 7 parts of bamboo charcoal fibers are added in 3% acetic acid solution of 8 times of its volume, stir process 25min under 900rpm, so
After filter, distill water washing 4 times, be dried at 60 DEG C water content be 8%;
(2) 4 parts of nano-titanium dioxides, 2 parts of graphene oxides are put into ball mill and are sufficiently mixed uniformly, then 140
DEG C vacuum oven, 5h is handled in nitrogen atmosphere, is added in the silane coupler solution of 12 times of its volume after cooling, at 35 DEG C
Under, using ultrasonic treatment 25min, bamboo charcoal fiber is then added, continues with 40min, filters, gains are put into microwave device
In, 25s is handled under 600W, is sent in vaporium after taking-up, and 35min is steamed, it is then dry at 65 DEG C.
Further, upper epidermis is medical pressure-sensing glue-line.
Further, in use, hydrogel antibiotic layer is made to be bonded skin.
Further, the second for the silane resin acceptor kh-550 that step (2) the silane coupler solution mass concentration is 6%
Alcoholic solution.
Further, step (2) the ultrasonic treatment condition is 90Hz.
Embodiment 3
A kind of medical bandage of aqueous gel antibiotic layer, including middle layer and the upper surface layer for being located at middle layer two sides under
Superficial layer, which is characterized in that layer is hydrogel antibiotic layer, is made of raw material from the following weight: konjac glucomannan 20, chitosan
20, berberine 0.3, ammonium persulfate solution 10, N, N'- methylene-bisacrylamide 10.
The ammonium persulfate solution mass concentration is 8%.
Further, the layer the preparation method comprises the following steps:
(1) chitosan is dissolved in 5% acetic acid, the chitosan solution that mass concentration is 3% is made, konjac glucomannan, Huang is then added
Ammonium persulfate solution is added at 70 DEG C, stirring and dissolving 80min under 400rpm in Lian Su, Aloe Vera Gel while stirring, stirs 30min
Afterwards, N is added, N'- methylene-bisacrylamide continues to stir 50min, is then allowed to stand 2h, obtains spinning solution;
(2) method of electrostatic spinning is utilized, spinning forms a film on the middle layer by spinning solution obtained by step (1), then by gains
Preservative film is covered, is placed in 65 DEG C of environment and stands 10h.
Further, middle layer is the base cloth layer of the fiber containing modification bamboo charcoal, and bamboo charcoal fiber method of modifying is as follows:
(1) 10 parts of bamboo charcoal fibers are added in 5% acetic acid solution of 10 times of its volume, stir process 30min under 1000rpm,
Then it filters, distills water washing 5 times, it is 10% that water content is dried at 70 DEG C;
(2) 5 parts of nano-titanium dioxides, 2 parts of graphene oxides are put into ball mill and are sufficiently mixed uniformly, then 150
DEG C vacuum oven, 6h is handled in nitrogen atmosphere, is added in the silane coupler solution of 15 times of its volume after cooling, at 40 DEG C
Under, using ultrasonic treatment 30min, bamboo charcoal fiber is then added, continues with 60min, filters, gains are put into microwave device
In, 30s is handled under 800W, is sent in vaporium after taking-up, and 40min is steamed, it is then dry at 70 DEG C.
Further, upper epidermis is medical pressure-sensing glue-line.
Further, in use, hydrogel antibiotic layer is made to be bonded skin.
Further, the second for the silane resin acceptor kh-550 that step (2) the silane coupler solution mass concentration is 10%
Alcoholic solution.
Further, step (2) the ultrasonic treatment condition is 100Hz.
Comparative example 1
The addition of berberine is omitted compared to embodiment 1 in this comparative example, and method and step in addition to this is all the same.
Comparative example 2
The addition of Aloe Vera Gel is omitted compared to embodiment 1 in this comparative example, and method and step in addition to this is all the same.
Comparative example 3
The modifying processing step of bamboo charcoal fiber, method and step in addition to this is omitted compared to embodiment 1 in this comparative example
It is all the same.
Comparative example 4
The addition of bamboo charcoal fiber is omitted compared to embodiment 1 in this comparative example, and method and step in addition to this is all the same.
Experiment:
Anti-microbial property test: choosing staphylococcus aureus, Escherichia coli, helicobacter pylori, Candida albicans is experimental subjects,
Test the anti-microbial property of each group sample.
Bursting Properties test: it is tested using Bursting Properties of the electronic fabric bursting strength instrument to each group sample, sample
Diameter be 6cm, intermediate aperture is 2.5cm, and the diameter of pellet is 2cm, and the speed of use is 100mm/min, gauge setting
For 450mm, per sample (p.s.) selects three pieces, calculates its average value.
Permeability test: using computermatic air permeability tester according to GB/T 5453-1997 standard, at 22 DEG C, relatively
The permeability of each group sample is tested in the environment of humidity 60%.
Test result is as shown in table 1:
Table 1
As shown in Table 1, the medical bandage of aqueous gel antibiotic layer prepared by the present invention has good antibacterial effect, while its
Mechanical property significantly improves, and gas permeability is preferable.
Claims (7)
1. a kind of medical bandage of aqueous gel antibiotic layer, including middle layer and be located at the upper surface layers of middle layer two sides with
Undersurface layer, which is characterized in that layer is hydrogel antibiotic layer, is made of raw material from the following weight: konjac glucomannan 10-20,
Chitosan 10-20, berberine 0.2-0.3, ammonium persulfate solution 5-10, N, N'- methylene-bisacrylamide 5-10.
The ammonium persulfate solution mass concentration is 4-8%.
2. a kind of medical bandage of aqueous gel antibiotic layer according to claim 1, which is characterized in that the layer
The preparation method comprises the following steps:
(1) chitosan is dissolved in the acetic acid of 2-5%, the chitosan solution that mass concentration is 2-3% is made, konjaku is then added
Glue, berberine, Aloe Vera Gel, the stirring and dissolving 40-80min under 50-70 DEG C, 300-400rpm, are added ammonium persulfate while stirring
After stirring 15-30min, N is added in solution, and N'- methylene-bisacrylamide continues to stir 30-50min, is then allowed to stand 1-2h,
Obtain spinning solution;
(2) method of electrostatic spinning is utilized, spinning forms a film on the middle layer by spinning solution obtained by step (1), then by gains
Preservative film is covered, is placed in 55-65 DEG C of environment and stands 5-10h.
3. a kind of medical bandage of aqueous gel antibiotic layer according to claim 1, which is characterized in that middle layer is containing changing
The base cloth layer of property bamboo charcoal fiber, bamboo charcoal fiber method of modifying are as follows:
(1) it in the acetic acid solution for the 2-5% that 5-10 parts of bamboo charcoal fibers are added to 5-10 times of its volume, is stirred under 800-1000rpm
20-30min is handled, is then filtered, is distilled water washing 3-5 times, it is 5-10% that water content is dried at 50-70 DEG C;
(2) 3-5 parts of nano-titanium dioxides, 1-2 parts of graphene oxides are put into ball mill and are sufficiently mixed uniformly, then existed
130-150 DEG C of vacuum oven handles 4-6h in nitrogen atmosphere, the silane coupling agent of 10-15 times of its volume is added after cooling
In solution, at 30-40 DEG C, using ultrasonic treatment 20-30min, bamboo charcoal fiber is then added, continues with 30-60min, mistake
Filter, gains are put into microwave device, 20-30s is handled under 500-800W, is sent in vaporium after taking-up, steam 30-
40min is then dry at 60-70 DEG C.
4. a kind of medical bandage of aqueous gel antibiotic layer according to claim 1, which is characterized in that upper epidermis is medical
Pressure-sensitive adhesive layer.
5. a kind of medical bandage of aqueous gel antibiotic layer according to claim 1, which is characterized in that in use, making water
Gel antibiotic layer is bonded skin.
6. modification bamboo charcoal method for modifying fibers according to claim 3, which is characterized in that step (2) is described silane coupled
Agent solution mass concentration is the ethanol solution of the silane resin acceptor kh-550 of 3-10%.
7. modification bamboo charcoal method for modifying fibers according to claim 3, which is characterized in that step (2) described ultrasonic treatment
Condition is 80-100Hz.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810731442.1A CN108939126A (en) | 2018-07-05 | 2018-07-05 | A kind of medical bandage of aqueous gel antibiotic layer |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201810731442.1A CN108939126A (en) | 2018-07-05 | 2018-07-05 | A kind of medical bandage of aqueous gel antibiotic layer |
Publications (1)
Publication Number | Publication Date |
---|---|
CN108939126A true CN108939126A (en) | 2018-12-07 |
Family
ID=64486029
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201810731442.1A Pending CN108939126A (en) | 2018-07-05 | 2018-07-05 | A kind of medical bandage of aqueous gel antibiotic layer |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN108939126A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110725044A (en) * | 2019-11-08 | 2020-01-24 | 南通大学 | Elastic medical bandage with composite structure and preparation method thereof |
CN111808581A (en) * | 2020-07-22 | 2020-10-23 | 西南石油大学 | Chitosan graphene oxide nano hydrogel plugging agent and water-based drilling fluid |
CN114274611A (en) * | 2022-01-13 | 2022-04-05 | 杭州聚奎科技有限公司 | Anti-skid floor mat and preparation method thereof |
CN117695428A (en) * | 2023-10-17 | 2024-03-15 | 山东威高新生医疗器械有限公司 | Medical grade silicon rubber capable of contacting wound surface |
Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101224310A (en) * | 2008-01-18 | 2008-07-23 | 中国人民解放军第四军医大学 | Medical wound dressing with anti-bacterial nanometer particulate |
CN102499992A (en) * | 2011-10-21 | 2012-06-20 | 大连创达技术交易市场有限公司 | Manufacturing method of novel carbon fiber medical bandage |
CN102926016A (en) * | 2012-10-31 | 2013-02-13 | 西南科技大学 | Method for preparing modified konjac glucomannan fiber by electrostatic spinning |
CN103505325A (en) * | 2012-06-21 | 2014-01-15 | 杨浩 | Bamboo carbon fiber wound paste and manufacturing method thereof |
US20160024690A1 (en) * | 2013-03-14 | 2016-01-28 | Lifenet Health | Electrospinning Apparatus and Methods of Use Thereof |
CN105482417A (en) * | 2015-12-20 | 2016-04-13 | 青岛科技大学 | Method for preparing graphene-containing polymer composite |
CN106188986A (en) * | 2016-08-30 | 2016-12-07 | 鄢海军 | A kind of callosity being applied to automobile inner air purification |
CN107375736A (en) * | 2017-07-21 | 2017-11-24 | 福建农林大学 | A kind of konjaku glucomannan medicine pastes and preparation method thereof more enough |
CN107670093A (en) * | 2017-11-18 | 2018-02-09 | 安徽玉然经编科技有限公司 | A kind of anti-sticky type antibacterial medical bandage |
CN108035165A (en) * | 2017-12-21 | 2018-05-15 | 芜湖品度电子科技有限公司 | Mould-proof antibacterial braid and preparation method thereof |
-
2018
- 2018-07-05 CN CN201810731442.1A patent/CN108939126A/en active Pending
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101224310A (en) * | 2008-01-18 | 2008-07-23 | 中国人民解放军第四军医大学 | Medical wound dressing with anti-bacterial nanometer particulate |
CN102499992A (en) * | 2011-10-21 | 2012-06-20 | 大连创达技术交易市场有限公司 | Manufacturing method of novel carbon fiber medical bandage |
CN103505325A (en) * | 2012-06-21 | 2014-01-15 | 杨浩 | Bamboo carbon fiber wound paste and manufacturing method thereof |
CN102926016A (en) * | 2012-10-31 | 2013-02-13 | 西南科技大学 | Method for preparing modified konjac glucomannan fiber by electrostatic spinning |
US20160024690A1 (en) * | 2013-03-14 | 2016-01-28 | Lifenet Health | Electrospinning Apparatus and Methods of Use Thereof |
CN105482417A (en) * | 2015-12-20 | 2016-04-13 | 青岛科技大学 | Method for preparing graphene-containing polymer composite |
CN106188986A (en) * | 2016-08-30 | 2016-12-07 | 鄢海军 | A kind of callosity being applied to automobile inner air purification |
CN107375736A (en) * | 2017-07-21 | 2017-11-24 | 福建农林大学 | A kind of konjaku glucomannan medicine pastes and preparation method thereof more enough |
CN107670093A (en) * | 2017-11-18 | 2018-02-09 | 安徽玉然经编科技有限公司 | A kind of anti-sticky type antibacterial medical bandage |
CN108035165A (en) * | 2017-12-21 | 2018-05-15 | 芜湖品度电子科技有限公司 | Mould-proof antibacterial braid and preparation method thereof |
Non-Patent Citations (2)
Title |
---|
LIHONG FAN ET AL.: "Preparation and Properties of Chitosan/Konjac Glucomannan Blend Fibers", 《JOURNAL OF MACROMOLECULAR SCIENCE , PART A: PURE AND APPLIED CHEMISTRY》 * |
何建新等: "《新型纤维材料学》", 31 July 2014, 东华大学出版社 * |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110725044A (en) * | 2019-11-08 | 2020-01-24 | 南通大学 | Elastic medical bandage with composite structure and preparation method thereof |
CN110725044B (en) * | 2019-11-08 | 2021-02-02 | 南通大学 | Elastic medical bandage with composite structure and preparation method thereof |
CN111808581A (en) * | 2020-07-22 | 2020-10-23 | 西南石油大学 | Chitosan graphene oxide nano hydrogel plugging agent and water-based drilling fluid |
CN111808581B (en) * | 2020-07-22 | 2022-04-19 | 西南石油大学 | Chitosan graphene oxide nano hydrogel plugging agent and water-based drilling fluid |
CN114274611A (en) * | 2022-01-13 | 2022-04-05 | 杭州聚奎科技有限公司 | Anti-skid floor mat and preparation method thereof |
CN117695428A (en) * | 2023-10-17 | 2024-03-15 | 山东威高新生医疗器械有限公司 | Medical grade silicon rubber capable of contacting wound surface |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN108939126A (en) | A kind of medical bandage of aqueous gel antibiotic layer | |
CN102908653A (en) | Preparation method of antiseptic dressing for deep infection wound | |
US9555149B2 (en) | Medical material employing carboxymethyl cellulose | |
CN113018502B (en) | Medical multifunctional hemostatic dressing and preparation method thereof | |
WO2012092813A1 (en) | Wound dressing with high moisture absorption and capable of being removed as a whole | |
CN107296975A (en) | A kind of antibacterial anti hemorrhagic based composite dressing for medical use and preparation method thereof | |
CN109731121A (en) | A kind of preparation method of the cellulose containing mesoporous silicon oxide and chitosan combine dressing | |
CN109276743B (en) | Quick-acting hemostatic yarn for promoting wound healing and preparation method and application thereof | |
CN110433321A (en) | A kind of preparation method of the medical foam dressing with sustained-release antibacterial | |
CN110549696B (en) | Hyaluronic acid-based skin-friendly cloth and preparation method thereof | |
CN105126150A (en) | Adhesive bandage containing chitosan mixture and preparation method of adhesive bandage | |
CN108472403B (en) | Sheet for covering wound | |
CN107670093A (en) | A kind of anti-sticky type antibacterial medical bandage | |
CN116688211A (en) | Regenerated cellulose non-woven fabric based on chitosan modification and preparation method and application thereof | |
CN110478516A (en) | A kind of strong water suction high resiliency medical antibacterial bandage | |
CN113073469B (en) | Preparation method of medical antibacterial gauze | |
CN104353103A (en) | Antibacterial medical hydrogel dressing and preparation method thereof | |
CN104324413A (en) | Preparation method of hydrogel dressing | |
CN105088779B (en) | A kind of collagem membrane patch and preparation method thereof | |
CN108498842A (en) | A kind of medical dressing and preparation method thereof for external Wound care | |
CN103174017A (en) | Sodium alginate oxide modified chitosan fiber and preparation method and application thereof | |
CN111658814A (en) | Breathable wrapping material and preparation method thereof | |
CN107648658B (en) | Itching-relieving pain-relieving chitosan adhesive and preparation method thereof | |
KR20180041980A (en) | Manufacturing method water-soluble hydrofiber and wound dressing using the water-soluble hydrofiber | |
CN108744013B (en) | Preparation method and application of nano-silver-radix puerariae fiber dressing |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20181207 |
|
RJ01 | Rejection of invention patent application after publication |