CN107648658B - Itching-relieving pain-relieving chitosan adhesive and preparation method thereof - Google Patents
Itching-relieving pain-relieving chitosan adhesive and preparation method thereof Download PDFInfo
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- CN107648658B CN107648658B CN201710892862.3A CN201710892862A CN107648658B CN 107648658 B CN107648658 B CN 107648658B CN 201710892862 A CN201710892862 A CN 201710892862A CN 107648658 B CN107648658 B CN 107648658B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/62—Compostable, hydrosoluble or hydrodegradable materials
Abstract
The invention belongs to the technical field of medical dressings, and particularly relates to an itching-relieving pain-relieving chitosan adhesive and a preparation method thereof, wherein the adhesive mainly comprises the following components in parts by weight: 30-50% of acrylic acid modified palm fiber and 50-70% of chitosan nano germanium compound, the chitosan dressing has good effects of relieving itching and pain, can accelerate wound healing and reduce pain, and is simple in preparation process and low in cost, and the obtained dressing has good mechanical properties.
Description
Technical Field
The invention belongs to the technical field of medical dressings, and particularly relates to a chitosan band-aid adhesive capable of relieving itching and pain and a preparation method thereof.
Background
The medical dressing comprises natural gauze, synthetic fiber dressing, polymeric film dressing, foaming polymeric dressing, hydrocolloid dressing, alginate dressing and the like, and is used for covering medical materials of sores, wounds or other damages. With the intensive research on the pathophysiology of the wound healing process, people understand the wound healing process more and more deeply, thereby leading to the continuous improvement and development of medical wound dressings. Currently, alginate dressings and chitosan dressings are the most advanced medical dressings in the world. The chitosan dressing has more diversified functions, but the chitosan has no self-adhesiveness and poor gelatinizing property, so that the chitosan dressing needs to be further improved by adding auxiliary materials.
Chitin is a natural polymer material commonly existing in shells of shrimps, crabs, insects and the like, is a biological derivative resource which is second to cellulose in nature, chitosan is a viscous polysaccharide obtained by deacetylation of chitin, has good biodegradability and biocompatibility, has good effects of relieving and relieving pain for wound treatment, promotes wound healing, and reduces scar generation, but the chitosan has larger brittleness of a membrane material, and is commonly blended to improve the performance, so that the wound treatment effect is further improved.
The Chinese patent application with publication number CN105833339A discloses a medical functional chitosan dressing, which consists of the following components in percentage by mass: 0.4-0.8% of carbomer, 0.5-1.5% of water-soluble chitosan, 1-5% of glycerol, 0.2-0.5% of sodium benzoate, 0.2-0.6% of triethanolamine and 90-98% of purified water. The medical functional chitosan dressing disclosed by the invention utilizes chitosan with good water solubility as a material, so that the effects of diminishing inflammation and inhibiting bacteria, adsorbing inflammatory tissue seepage, promoting wound healing and growth and reducing scar formation are achieved.
Chinese patent with publication number CN103394114B discloses a preparation method of chitosan-based superfine fiber carrier material for medical dressing, which comprises the following steps: mixing chitosan powder and polyoxyethylene powder, and dissolving the chitosan powder and the polyoxyethylene powder in an acetic acid aqueous solution to prepare a spinning solution; adding the spinning solution into an electrostatic spinning device, carrying out electrostatic spinning, and receiving fibers on a cylindrical roller receiver to obtain a fiber membrane; the chitosan-based superfine fiber carrier material for the medical dressing has a superfine fiber structure and high porosity, has good water absorption, moisture retention and air permeability, has certain antibacterial property, is beneficial to healing of a wound surface, and can reduce the nursing strength.
Disclosure of Invention
In order to solve the defects in the prior art, the invention discloses an itching-relieving pain-relieving chitosan band-aid adhesive and a preparation method thereof.
The specific technical scheme of the invention is as follows:
the itching-relieving pain-relieving chitosan adhesive mainly comprises the following components in parts by weight: 30-50% of acrylic acid modified palm fiber and 50-70% of chitosan nano germanium compound.
Further, the itching-relieving pain-relieving chitosan adhesive for wound consists of the following components in parts by weight: 40% of acrylic acid modified palm fiber and 60% of chitosan nano germanium compound.
Further, the preparation method of the itching-relieving pain-relieving chitosan adhesive comprises the following steps:
(1) crushing the palm fiber to be 100-mesh and 150-mesh, mixing the crushed palm fiber with water, adding ammonium persulfate, uniformly stirring, standing for 1-2 hours, dropwise adding acrylic acid, and reacting for 2-3 hours under a water bath condition to obtain a reaction liquid a;
(2) cooling the reaction liquid a to 0 ℃, continuing to react for 20-24 hours to obtain a gelatinous substance, and washing the gelatinous substance by using deionized water until no residual raw material exists to obtain a gel b;
(3) and mixing the gel b and polyvinyl alcohol uniformly, and drying to obtain the product.
Further, in the step (1), the material ratio of the palm fiber, the water, the ammonium persulfate and the acrylic acid is 1g:15-25ml:0.018-0.022g:8-10 ml.
Furthermore, the material ratio of the polyvinyl alcohol to the palm fiber in the step (3) is 1g:2-4 ml.
Further, the chitosan nano germanium compound is composed of chitosan and nano germanium oxide according to the weight ratio of 1: 0.0001-0.0004.
The invention also provides a preparation method of the itching-relieving pain-relieving chitosan woundplast, which is characterized in that the chitosan nano germanium compound is dissolved in an acetic acid solution with the mass fraction of 2 percent to prepare the acetic acid solution of the chitosan nano germanium compound with the mass fraction of 4-6 percent, then acrylic acid modified palm fiber is added, the mixture is uniformly stirred and poured on a polyvinyl chloride plate to form a film while being stirred, and the itching-relieving pain-relieving chitosan woundplast is obtained.
The palm fiber is used and is a reticular palm-coat fiber formed by leaf sheaths at the periphery of a palm trunk, the palm fiber has an aggregation structure and small crystallinity, so that the tensile property of the palm fiber is better, the water retention and water retention effects of the fiber can be improved on the basis of keeping the original elasticity after acrylic acid grafting, the wound is kept in a moist state, excessive water is not contacted with the wound, the wound healing is accelerated, the palm fiber does not contain sugar, the palm fiber is not easy to mildew, bacteria are not easy to breed, the wound injury is reduced, the unique porous structure of the palm fiber is favorable for adsorbing chitosan, and the treatment effect of the chitosan on the wound is further improved; and the palm fiber belongs to a wet swelling and drying shrinkage material, is modified by acrylic acid and then is mixed with polyvinyl alcohol, so that the palm fiber material can keep a smaller deformation difference under wet and dry conditions, secondary damage to wounds is avoided, and further, the palm fiber is a naturally-occurring plant fiber, is low in use cost and simple in modification method, and is beneficial to further popularization.
The chitosan nano germanium compound is formed by compounding chitosan and germanium, wherein the chitosan has the effect of accelerating wound healing, and the germanium can also accelerate the wound healing, mainly because the germanium can enhance the cell activity, harmful substances in blood are rapidly discharged out of the body, and the wound healing is accelerated.
Compared with the prior art, the invention has the following advantages: (1) the palm fiber natural plant fiber is used for modification, and is compounded with chitosan for use, so that the cost is low, the composite chitosan fiber is biodegradable, has affinity with wounds such as skin, mucosa and the like, and is not adhered to the wounds; (2) the palm fiber used in the invention has good water retention and water retention performance, can improve the pain-relieving and itching-relieving effects of chitosan on wounds, does not stick to the wounds, and is beneficial to accelerating the healing of the wounds.
Detailed Description
The present invention is further illustrated by the following examples, which will enable those skilled in the art to better understand the technical solutions of the present invention.
Example 1 an antipruritic and analgesic chitosan adhesive
The itching-relieving pain-relieving chitosan adhesive is prepared from the following components in parts by weight: 40% of acrylic acid modified palm fiber and 60% of chitosan nano germanium compound;
the preparation method of the acrylic acid modified palm fiber comprises the following steps: (1) crushing the palm fiber to 120 meshes, mixing the crushed palm fiber with water, adding ammonium persulfate, uniformly stirring, standing for 1.5 hours, dropwise adding acrylic acid, and reacting for 2.5 hours under a water bath condition to obtain a reaction liquid a; wherein the material ratio of the palm fiber, the water, the ammonium persulfate and the acrylic acid is 1g:20ml:0.02g:9 ml;
(2) cooling the reaction liquid a to 0 ℃, continuing to react for 22 hours to obtain a gel substance, and washing the gel substance by using deionized water until no residual raw material exists to obtain a gel b;
(3) uniformly mixing the gel b with polyvinyl alcohol, and drying to obtain the palm fiber gel, wherein the material ratio of the polyvinyl alcohol to the palm fiber is 1g:3 ml;
the chitosan nano germanium compound consists of chitosan and nano germanium oxide according to the weight ratio of 1: 0.0002.
The preparation method comprises the following steps: dissolving chitosan nano germanium compound in acetic acid solution with mass fraction of 2%, preparing into acetic acid solution with mass fraction of 5%, adding acrylic acid modified palm fiber, stirring, pouring on polyvinyl chloride plate while stirring, and casting to form film.
Example 2 an antipruritic and analgesic chitosan adhesive
The itching-relieving pain-relieving chitosan adhesive is prepared from the following components in parts by weight: 30% of acrylic acid modified palm fiber and 70% of chitosan nano germanium compound;
the preparation method of the acrylic acid modified palm fiber comprises the following steps:
(1) crushing palm fibers to 100 meshes, mixing the crushed palm fibers with water, adding ammonium persulfate, uniformly stirring, standing for 1 hour, dropwise adding acrylic acid, and reacting for 2 hours under a water bath condition to obtain a reaction liquid a; wherein the material ratio of the palm fiber, the water, the ammonium persulfate and the acrylic acid is 1g:15ml:0.018g:8 ml;
(2) cooling the reaction liquid a to 0 ℃, continuing to react for 20 hours to obtain a gel substance, and washing the gel substance by using deionized water until no residual raw material exists to obtain a gel b;
(3) uniformly mixing the gel b with polyvinyl alcohol, and drying to obtain the palm fiber gel, wherein the material ratio of the polyvinyl alcohol to the palm fiber is 1g:2 ml;
wherein, the chitosan nano germanium compound consists of chitosan and nano germanium oxide according to the weight ratio of 1: 0.0001.
The preparation method of the itching-relieving pain-relieving chitosan woundplast is similar to that of example 1.
Example 3 an antipruritic and analgesic chitosan adhesive
The itching-relieving pain-relieving chitosan adhesive is prepared from the following components in parts by weight: 50% of acrylic acid modified palm fiber and 50% of chitosan nano germanium compound;
the preparation method of the acrylic acid modified palm fiber comprises the following steps:
(1) crushing the palm fiber to 150 meshes, mixing the crushed palm fiber with water, adding ammonium persulfate, uniformly stirring, standing for 2 hours, dropwise adding acrylic acid, and reacting for 3 hours under a water bath condition to obtain a reaction liquid a; wherein the material ratio of the palm fiber, the water, the ammonium persulfate and the acrylic acid is 1g:25ml:0.022g:10 ml;
(2) cooling the reaction liquid a to 0 ℃, continuing to react for 24 hours to obtain a gel substance, and washing the gel substance by using deionized water until no residual raw material exists to obtain a gel b;
(3) uniformly mixing the gel b with polyvinyl alcohol, and drying to obtain the palm fiber gel, wherein the material ratio of the polyvinyl alcohol to the palm fiber is 1g:4 ml;
wherein, the chitosan nano germanium compound consists of chitosan and nano germanium oxide according to the weight ratio of 1: 0.0004.
The preparation method of the itching-relieving pain-relieving chitosan woundplast is similar to that of example 1.
Comparative example 1 an antipruritic and analgesic chitosan adhesive
The itching-relieving pain-relieving chitosan adhesive is prepared from the following components in parts by weight: 40% of palm fiber compound and 60% of chitosan nano germanium compound;
the chitosan nano germanium compound is the same as the example 1.
The preparation method of the itching-relieving pain-relieving chitosan woundplast is similar to that of example 1.
The difference from example 1 is that the acrylic modified palm fibres were replaced by a palm fibre composite: specifically, the palm fibers are ground to 300 meshes, then uniformly mixed with polyvinyl alcohol, and dried to obtain the palm fiber.
Comparative example 2 an antipruritic and analgesic chitosan adhesive
The itching-relieving pain-relieving chitosan adhesive is prepared from the following components in parts by weight: 40% of acrylic acid modified palm fiber and 60% of chitosan nano germanium compound;
the chitosan nano germanium compound is the same as the compound in the embodiment 1;
the preparation method of the acrylic acid modified palm fiber comprises the following steps:
(1) crushing the palm fiber to 120 meshes, mixing the crushed palm fiber with water, adding ammonium persulfate, uniformly stirring, standing for 1.5 hours, dropwise adding acrylic acid, and reacting for 2.5 hours under a water bath condition to obtain a reaction liquid a; wherein the material ratio of the palm fiber, the water, the ammonium persulfate and the acrylic acid is 1g:20ml:0.05g:9 ml;
(2) cooling the reaction liquid a to 0 ℃, continuing to react for 22 hours to obtain a gel substance, and washing the gel substance by using deionized water until no residual raw material exists to obtain a gel b;
(3) and uniformly mixing the gel b with polyvinyl alcohol, and drying to obtain the palm fiber gel, wherein the material ratio of the polyvinyl alcohol to the palm fiber is 1g:3 ml.
The preparation method of the itching-relieving pain-relieving chitosan woundplast is similar to that of example 1.
The difference from example 1 is that the amount of ammonium persulfate used was increased in the process for preparing acrylic modified palm fiber.
Test example 1 Water holding force test
Test subjects: itching-relieving and pain-relieving chitosan wound adhesive prepared in examples 1-3 and comparative examples 1-2;
the test method comprises the following steps: placing 1g of prepared chitosan adhesive in 30ml of water, standing for 1 hour at room temperature, centrifuging for 10min at 1000r/min, removing supernatant, and weighing the wet weight of the residual chitosan adhesive, wherein the calculation mode is that the water holding capacity (g/g) is (the wet weight of the chitosan adhesive-1 g)/1 g; the results are shown in Table 1.
And (3) test results: the chitosan band-aid adhesive prepared by the invention has small deformation after being put into water, is not dissolved and has certain mechanical property.
TABLE 1 Water holding force
| Group of | Example 1 | Example 2 | Example 3 | Comparative example 1 | Comparative example 2 |
| Water holding capacity (%) | 505 | 462 | 451 | 302 | 386 |
As can be seen from table 1, the itching-relieving and pain-relieving chitosan band-aid adhesive prepared in examples 1 to 3 of the present invention has water retention capacity, which indicates that the chitosan band-aid adhesive disclosed by the present invention has good water resistance, i.e., does not dissolve in water to become sticky, and also has good water retention capacity, so that the wound can be kept in a moist state, and the healing of the wound is facilitated.
Test example 2 evaluation of Effect
Test subjects: itching-relieving and pain-relieving chitosan wound adhesive prepared in examples 1-3 and comparative examples 1-2;
establishing an animal model: 30 SD rats are immersed in boiling water at 100 deg.C with gauze 3mm thick, and then placed in the abdomen (after anesthesia) of the rat to-be-scalded region for 6s with scald area of 10cm2Selecting 25 rats with similar scald degree for test, and averagely dividingIs 5 groups;
the test method comprises the following steps: 30min after the animal model is established, removing blisters on the wound surface of a rat, cleaning the rat by using clear water, covering itching-relieving and pain-relieving chitosan woundplast on the wound, fixing the wound by using gauze, replacing the wound once a day, observing wound changes, timing the times of body twisting of the mouse (as an index for measuring the pain-relieving effect) within 40min after the first application, calculating the time for the mouse to bite the body cumulatively every day (as an index for measuring the itching-relieving effect), and counting the day with the most severe pruritus after the application, which is specifically shown in table 2.
TABLE 2 wound Change
As can be seen from Table 2, the chitosan band-aid adhesive prepared by the invention has good wound healing effect, wherein the band-aid adhesive in examples 1-3 can heal after being applied for 10 days, the wound surface has no silt marks and no pigment deposition, but the modification method and modification parameters of palm fibers are respectively changed in comparative examples 1-2, the wound surface effect is poor, the examples 1-3 of the invention have better pain relieving and itching relieving effects, the times of body twisting after application are reduced, and the biting time is shortened.
Claims (5)
1. The itching-relieving pain-relieving chitosan adhesive is characterized by mainly comprising the following components in parts by weight: 30-50% of acrylic acid modified palm fiber and 50-70% of chitosan nano germanium compound;
the preparation method of the acrylic acid modified palm fiber comprises the following steps:
(1) crushing the palm fiber to be 100-mesh and 150-mesh, mixing the crushed palm fiber with water, adding ammonium persulfate, uniformly stirring, standing for 1-2 hours, dropwise adding acrylic acid, and reacting for 2-3 hours under a water bath condition to obtain a reaction liquid a;
(2) cooling the reaction liquid a to 0 ℃, continuing to react for 20-24 hours to obtain a gelatinous substance, and washing the gelatinous substance by using deionized water until no residual raw material exists to obtain a gel b;
(3) mixing gel b with polyvinyl alcohol, and drying;
in the step (1), the material ratio of the palm fiber, the water, the ammonium persulfate and the acrylic acid is 1g:15-25mL:0.018-0.022g:8-10 mL.
2. The itching-relieving and pain-relieving chitosan adhesive according to claim 1, which is characterized by comprising the following components in parts by weight: 40% of acrylic acid modified palm fiber and 60% of chitosan nano germanium compound.
3. The itching-relieving and pain-relieving chitosan adhesive bandage as claimed in claim 1, wherein the material ratio of the polyvinyl alcohol to the palm fiber in the step (3) is 1g:2-4 mL.
4. The itching-relieving pain-relieving chitosan wound gel according to claim 1 or 2, wherein the chitosan nano germanium compound is composed of chitosan and nano germanium oxide according to the weight ratio of 1: 0.0001-0.0004.
5. The method for preparing itching-relieving and pain-relieving chitosan woundplast according to any one of claims 1-4, characterized in that the chitosan nano germanium compound is dissolved in 2% by mass of acetic acid solution to prepare 4-6% by mass of acetic acid solution of chitosan nano germanium compound, then acrylic acid modified palm fiber is added, and the mixture is stirred uniformly and poured on a polyvinyl chloride plate to form a film while stirring.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101212990A (en) * | 2005-07-01 | 2008-07-02 | 金文申有限公司 | Medical devices comprising a reticulated composite material |
| WO2010052191A2 (en) * | 2008-11-04 | 2010-05-14 | Universitetet I Oslo | Coated solid pliant materials |
| CN104368033A (en) * | 2014-10-23 | 2015-02-25 | 天津工业大学 | Highly-bacteriostatic fast-healing fiber, membrane and massive sericin based dressing and preparation method thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101212990A (en) * | 2005-07-01 | 2008-07-02 | 金文申有限公司 | Medical devices comprising a reticulated composite material |
| WO2010052191A2 (en) * | 2008-11-04 | 2010-05-14 | Universitetet I Oslo | Coated solid pliant materials |
| CN104368033A (en) * | 2014-10-23 | 2015-02-25 | 天津工业大学 | Highly-bacteriostatic fast-healing fiber, membrane and massive sericin based dressing and preparation method thereof |
Non-Patent Citations (1)
| Title |
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| 棕榈纤维/聚丙烯复合材料的制备和力学性能研究;陈卉颖;《中国优秀硕士学位论文全文数据库 工程科技Ⅰ辑》;20120715;第2012年卷(第07期);全文 * |
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