CN108939034A - 疤痕修复膏 - Google Patents

疤痕修复膏 Download PDF

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CN108939034A
CN108939034A CN201811153516.4A CN201811153516A CN108939034A CN 108939034 A CN108939034 A CN 108939034A CN 201811153516 A CN201811153516 A CN 201811153516A CN 108939034 A CN108939034 A CN 108939034A
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赵升瑞
赵景颢
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Abstract

一种疤痕修复膏，由凉血润燥、软化皮肤的组份A；活血化瘀，软坚散结的组份B；破坏DNA复制，抑制异常成纤维细胞的形成和分化，杀死变异异常的皮肤细胞的组份C；激活该区域毛细血管的恢复，改善疤痕微循环的组份D；激发黑色素细胞形成、通窍、长毛发的组份E按重量比混合制成。本发明通过止痒止痛、杀菌消炎、化瘀消肿、活血生机、通窍长毛、杀死成纤维细胞和角质化细胞、激发皮肤细胞黑色素的形成，使疤痕症状消失。疗程短、疗效好、费用低。

Description

疤痕修复膏
技术领域
本发明属于中药技术领域，具体涉及一种疤痕修复膏。
背景技术
目前，祛除疤痕的药物很多，有国产的中药和西药，还有进口的西药软膏，虽有一定的疗效，能使疤痕减小和白色变淡的效果，但不能使疤痕完全消失，而且疗程长，见效慢，费用高。更有甚者，有的还要用针扎破疤痕，使药物进入疤痕内起作用，给患者带来痛苦。
发明内容
本发明提供一种疤痕修复膏，纯中药制剂，仅外敷即可，治疗程序简单、疗程短、疗效好、费用低。
按照疤痕发病的西医学理论疤痕主要有三大类：增生性疤痕(疤痕疙瘩、白色发亮扁平型疤痕)、萎缩性疤痕、混合性疤痕。增生性疤痕形成的原因有以下几个方面：其一、有的人属于疤痕性体质，皮肤受损都容易留下疤痕。其二、伤口愈合过程中细胞的快速增殖分化导致新产生的细胞发生变异，不能形成正常的皮肤角质层细胞，而是形成了异常的成纤维细胞。其三变异的原因一方面来自于细菌和病毒的感染，另一方面由于细胞的快速增殖和分化使某些细胞的基因不能充分表达，有些基因表达过度，才形成异常成纤维细胞。成纤维细胞的胶原纤维生成素基因过度表达，导致胶原纤维生成素过度沉积。另一方面成纤维细胞中黑色素基因表达不足，导致成纤维细胞成白色。第三异常粘多糖的出现，淋巴液减少导致局部水肿，所以增生性疤痕大多为肿胀角化、色白、突出皮肤表面。
萎缩性疤痕形成的原因有以下几个方面：受伤严重时皮肤真皮、肌肉组织、结缔组织受损；肌肉组织和结缔组织不能再生，生发层细胞分裂速度减慢。混合性疤痕既有增生性疤痕又有萎缩性疤痕，所以它形成的原因与上述两方面相同。
按照疤痕发病的中医学原理，在中医发展不同时期，有不同的分类方法。不同流派也有不同的分类方法。根据前人的分类方法和本人的临床总结，从中医方面对疤痕的分类如下：
血脉不通，经络阻断型：由于血脉不通，经络阻断，造成受伤部位气血不足，肌肤失养，肌肤生长受阻，导致疤痕呈凹陷性，低于正常皮肤。
气血壅滞，湿热瘀结型：由于气血壅滞、湿热瘀结，导致疤痕发红、肿胀、坚硬，呈球形、长条形、不规则形等的突起，这就是疤痕疙瘩。
血热致燥型：由于伤口恢复期间，该部位血过热导致血燥，疤痕略高于皮肤多呈扁平型，表皮白色发亮是其典型特征。
本发明根据中西医疤痕形成的机理和现存疤痕药物存在的缺点，认为应从以下方面治疗疤痕：
第一，凉血润燥、软化皮肤，杀死变异的异常的皮肤细胞。不论是哪一类疤痕，共同特点是疤痕表面都有一层发硬的异常角质层细胞(成纤维细胞)。通过使用凉血润燥软化皮肤的中药药物，一是可以降低皮肤的温度，使异常细胞增值速度减慢；二是满足正常细胞分裂分化生长发育的正常温度，将皮肤软化，进而使其他药物容易进入硬化的皮肤内，提高疗效。通过药物杀死异常的角质细胞，为正常的皮肤生长提供场所；有了正常的温度也能够使细胞正常分裂，产生正常的角质层细胞。
第二、活血化瘀，软坚散结。所有的疤痕都有气淤和血瘀的问题，通过使用活血化瘀软坚散结的中药药物，可以起到排除疤痕部位的代谢废物，更重要的能够将疤痕部位的炎症因子疏导疏散开来，肿胀不会加重，甚至减小。活血化瘀软坚散结可以加速代谢，肿胀逐渐消退，使疤痕部位的黑色素退去。
第三、破坏DNA的复制，抑制异常的成纤维细胞的形成和分化。诱导分化产生正常的皮肤角质层细胞。
第四、激活该区域毛细血管的恢复改善，使疤痕区域得到充分的营养和氧气供应，为分裂分化出正常的角质层细胞提供必需的生存环境。
第五、激发黑色素细胞的形成，通过激发疤痕区域皮肤形成正常的毛囊、毛孔，长出毛发，修复皮肤，从而形成正常的皮肤细胞。
本发明所述疤痕修复膏由下述重量比的组份混合后密封保存15-20日制成：凉血润燥、软化皮肤的组份A 1-3；活血化瘀，软坚散结的组份B 1-4；破坏DNA复制，抑制异常的成纤维细胞的形成和分化，杀死变异异常的皮肤细胞的组份C 1-4；激活该区域毛细血管的恢复，改善疤痕微循环的组份D 1-5；激发黑色素细胞形成、通窍、长毛发的组份E 1-3。
所述组份A由大蒜45-55g、洋葱90-110g、鸦胆子仁18-22g、冰醋酸9-11ml制成；制备方法：先将鸦胆子仁粉碎至≥80目，再将大蒜、洋葱捣碎，与粉碎后的鸦胆子仁混合后加入冰醋酸密封15-20日得到组份A；
所述组份B由黄柏45-55g、赤芍药2-4g、川芎2-4g、桃仁5-7g、红花8-10g、生姜8-10g、葱白13-17g、大枣4-6g、黄酒225-275ml制成；制备方法：先将黄柏、赤芍药、川芎、桃仁、红花混合后粉碎至≥80目，再将生姜、葱白、大枣捣碎与粉碎后的药物混合后水煎20-30分钟，在水煎液中加入黄酒密封浸泡10-15日得到组份B；
所述组份C由大叶青25-35g、鲜银杏果仁18-22g、垂盆草27-33g、活蚯蚓90-110g、食用酒精45-55ml、冰醋酸4-6ml、白砂糖45-55g制成；制备方法：先将大叶青、鲜白果仁、垂盆草混合粉碎至≥80目后加入食用酒精、冰醋酸密封10-15日得到中间组份，将白砂糖撒在活蚯蚓上使其全部融化后再与所述中间组份混合得到组份C；
所述组份D由活水蛭18-22g、三七粉27-33g、乳香8-11g、没药8-11g、马钱子8-11g、丹参8-11g、白芨18-22g、食用酒精45-55ml制成；制备方法：将三七粉、乳香、没药、马钱子、丹参、白芨混合后粉碎至≥80目，活水蛭捣碎，二者混合加入食用酒精密封15-20日即可；
所述组份E由猫爪草18-22g、白蒺藜18-22g、麝香0.15-0.2g、补骨脂18-22g、寒水石9-11g、食用酒精45-55ml制成；制备方法：将猫爪草、白蒺藜、补骨脂、寒水石混合后粉碎至≥80目，加入麝香、食用酒精密封保存15-20日得到组份E。
优选，所述疤痕修复膏由下述重量比的组份混合后密封保存15-20日制成：A:B:C:D:E＝1:2:2:5:1。
优选，所述疤痕修复膏由下述重量比的组份混合后密封保存15-20日制成：A:B:C:D:E＝1:4:1:1:1。
优选，所述疤痕修复膏由下述重量比的组份混合后密封保存15-20日制成：A:B:C:D:E＝3:1:4:1:3。
本发明具有的优点和效果：
1、通过杀死成纤维细胞，能使增生的疤痕(高于正常皮肤)通过褪皮和正常皮肤同高度。
2、通过刺激萎缩性疤痕细胞下的正常生发层细胞加快细胞分裂速度，产生正常的皮肤细胞，能使萎缩性疤痕(低于正常皮肤，有凹坑)部位的正常细胞生长到正常皮肤高度。
3、通过激发黑色素细胞产生适量的色素，使疤痕部位的皮肤颜色恢复到正常皮肤的颜色。
4、促进伤口愈合，只要是皮肤肌肉软组织损伤的伤口，不管多深、多宽、多长的伤口，不用手术缝合都能使其快速愈合，不留任何疤痕，且愈合速度与不留疤痕的优点是目前国内外的同类产品所无法达到的。
5、纯中药制品，无刺激性，无激素和化学添加剂，无防腐剂，疗程短，疗效好。
具体实施方式
本发明由凉血润燥、软化皮肤的组份A；活血化瘀，软坚散结的组份B；破坏DNA复制，抑制异常成纤维细胞的形成和分化，杀死变异异常的皮肤细胞的组份C；激活该区域毛细血管的恢复，改善疤痕微循环的组份D；激发黑色素细胞形成、通窍、长毛发的组份E按重量比混合制成。
所述组份A由大蒜50g、洋葱100g、鸦胆子仁20g、冰醋酸10ml制成；制备方法：先将鸦胆子仁粉碎至≥80目，再将大蒜、洋葱捣碎，与粉碎后的鸦胆子仁混合后加入冰醋酸密封15-20日得到组份A；
所述组份B由黄柏50g、赤芍药3g、川芎3g、桃仁6g、红花9g、生姜9g、葱白15g、大枣5g、黄酒250ml制成；制备方法：先将黄柏、赤芍药、川芎、桃仁、红花混合后粉碎至≥80目，再将生姜、葱白、大枣捣碎与粉碎后的药物混合后水煎20-30分钟，在水煎液中加入黄酒密封浸泡10-15日得到组份B；
所述组份C由大叶青30g、鲜银杏果仁20g、垂盆草30g、活蚯蚓100g、食用酒精50ml、冰醋酸5ml、白砂糖50g制成；制备方法：先将大叶青、鲜白果仁、垂盆草混合粉碎至≥80目后加入食用酒精、冰醋酸密封10-15日得到中间组份，将白砂糖撒在活蚯蚓上使其全部融化后再与所述中间组份混合得到组份C；
所述组份D由活水蛭20g、三七粉30g、乳香9g、没药9g、马钱子9g、丹参9g、白芨9g、食用酒精50ml制成；制备方法：将三七粉、乳香、没药、马钱子、丹参、白芨混合后粉碎至≥80目，活水蛭捣碎，二者混合加入食用酒精密封15-20日即可；
所述组份E由猫爪草20g、白蒺藜20g、麝香0.15g、补骨脂20g、寒水石10g、食用酒精50ml制成；制备方法：将猫爪草、白蒺藜、补骨脂、寒水石混合后粉碎至≥80目，加入麝香、食用酒精密封保存15-20日得到组份E。
针对萎缩性疤痕，所述疤痕修复膏由下述重量比的组份混合后密封保存15-20日制成：A:B:C:D:E＝1:2:2:5:1。
针对疤痕疙瘩(疤痕瘤)，所述疤痕修复膏由下述重量比的组份混合后密封保存15-20日制成：A:B:C:D:E＝1:4:1:1:1。
针对扁平发白增生性疤痕，所述疤痕修复膏由下述重量比的组份混合后密封保存15-20日制成：A:B:C:D:E＝3:1:4:1:3。
本发明治疗范围：烧伤、烫伤、手术、动物咬伤、机械损伤、痤疮等形成的疤痕(增生性疤痕、萎缩性疤痕、混合性疤痕)。
本发明用法:外用，直接涂抹在患处，两天换一次药，一个疗程两个月。注意首次使用前需在手臂前侧做过敏测试(24小时)。
本发明经宝鸡市渭滨区中滩路社区卫生站、宝鸡市渭滨区英达路康达诊所临床观察，结果如下：
本发明通过止痒止痛、杀菌消炎、化瘀消肿、活血生机、通窍长毛、杀死成纤维细胞和角质化细胞、激发皮肤细胞黑色素的形成，使疤痕症状消失。本发明治愈率达到了100％，治愈以疤痕症状消失，恢复正常皮肤为判断标准。
上述实施例，只是本发明的较佳实施例，并非用来限制本发明的实施范围，故凡以本发明权利要求所述内容所做的等同变化，均应包括在本发明权利要求范围之内。

Claims (4)

1.一种疤痕修复膏，其特征在于：
所述疤痕修复膏由下述重量比的组份混合后密封保存15-20日制成：组份A 1-3、组份B1-4、组份C 1-4、组份D 1-5、组份E 1-3；
所述组份A由大蒜45-55g、洋葱90-110g、鸦胆子仁18-22g、冰醋酸9-11ml制成；制备方法：先将鸦胆子仁粉碎至≥80目，再将大蒜、洋葱捣碎，与粉碎后的鸦胆子仁混合后加入冰醋酸密封15-20日得到组份A；
所述组份B由黄柏45-55g、赤芍药2-4g、川芎2-4g、桃仁5-7g、红花8-10g、生姜8-10g、葱白13-17g、大枣4-6g、黄酒225-275ml制成；制备方法：先将黄柏、赤芍药、川芎、桃仁、红花混合后粉碎至≥80目，再将生姜、葱白、大枣捣碎与粉碎后的药物混合后水煎20-30分钟，在水煎液中加入黄酒密封浸泡10-15日得到组份B；
所述组份C由大叶青25-35g、鲜银杏果仁18-22g、垂盆草27-33g、活蚯蚓90-110g、食用酒精45-55ml、冰醋酸4-6ml、白砂糖45-55g制成；制备方法：先将大叶青、鲜白果仁、垂盆草混合粉碎至≥80目后加入食用酒精、冰醋酸密封10-15日得到中间组份，将白砂糖撒在活蚯蚓上使其全部融化后再与所述中间组份混合得到组份C；
所述组份D由活水蛭18-22g、三七粉27-33g、乳香8-11g、没药8-11g、马钱子8-11g、丹参8-11g、白芨18-22g、食用酒精45-55ml制成；制备方法：将三七粉、乳香、没药、马钱子、丹参、白芨混合后粉碎至≥80目，活水蛭捣碎，二者混合加入食用酒精密封15-20日即可；
所述组份E由猫爪草18-22g、白蒺藜18-22g、麝香0.15-0.2g、补骨脂18-22g、寒水石9-11g、食用酒精45-55ml制成；制备方法：将猫爪草、白蒺藜、补骨脂、寒水石混合后粉碎至≥80目，加入麝香、食用酒精密封保存15-20日得到组份E。
2.根据权利要求1所述的疤痕修复膏，其特征在于所述疤痕修复膏由下述重量比的组份混合后密封保存15-20日制成：A:B:C:D:E＝1:2:2:5:1。
3.根据权利要求1所述的疤痕修复膏，其特征在于所述疤痕修复膏由下述重量比的组份混合后密封保存15-20日制成：A:B:C:D:E＝1:4:1:1:1。
4.根据权利要求1所述的疤痕修复膏，其特征在于所述疤痕修复膏由下述重量比的组份混合后密封保存15-20日制成：A:B:C:D:E＝3:1:4:1:3。
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Application publication date: 20181207