CN108938960A - A kind of drug and preparation method thereof for treating gastric cancer - Google Patents
A kind of drug and preparation method thereof for treating gastric cancer Download PDFInfo
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Abstract
The invention discloses a kind of drugs and preparation method thereof for treating gastric cancer, are related to technical field of traditional Chinese medicines.Drug of the invention, the raw material including following parts by weight: 30-60 parts of radix pseudostellariae, 30-60 parts of Radix Astragali, 10-20 parts of Radix Glycyrrhizae, 20-30 parts of dendrobium nobile, 10-20 parts of dark plum, 15-30 parts of stir-baked RADIX PAEONIAE ALBA, 20-60 parts of Sculellaria barbata, 30-60 parts of mock-strawberry, 10-30 parts of lizard, 10-30 parts of Fructus Aurantii, 3-6 parts of Radix Notoginseng powder, 15-30 parts of edible tulip, 30-90 parts of semen coicis, 10-30 parts of radix scutellariae.Using the therapeutic effect of 50 gastric cancers of drug therapy of the invention: have in 50 after treating 1 each course for the treatment of 31 it is effective, 12 are effectively, and 7 are invalid, and total effective rate reaches 86%.The drug for the treatment of gastric cancer of the invention can improve the clinical symptoms of gastric cancer, curative for effect, Small side effects.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines more particularly to a kind of drugs and preparation method thereof for treating gastric cancer.
Background technique
Gastric cancer (part astric carcinoma) is initiated by the malignant tumour of gastric epithelial, various pernicious swollen in China
Disease incidence ranks first in tumor.Due to the change of dietary structure, operating pressure increases and the reasons such as the infection of helicobacter pylori, makes
It obtains gastric cancer and rejuvenation tendency is presented.Gastric cancer can betide any position of stomach, wherein more than half betide antrum portion, stomach is big
Curved, lesser curvature and front and rear wall can be involved.Most gastric cancers belong to gland cancer, early stage non-evident sympton, or epigastric discomfort occur,
The nonspecific symptoms such as belch, often and gastritis, the stomaches chronic disease symptom such as gastric ulcer is similar, is easily ignored, therefore, China at present
The early diagnostic rate of gastric cancer is still lower.
The prognosis of gastric cancer and the pathological staging of gastric cancer, position, organization type, biological behaviour and remedy measures are related.
Early carcinoma of stomach most of patients non-evident sympton, a few peoples have the digestive symptoms of nausea, vomiting or similar canker, it is difficult to
Cause enough attention.With the growth of tumour, influence just occur more apparent symptom when stomach function, but lack special
Property.Pain and weight loss are the most common clinical symptoms of advanced gastric carcinoma.The more specific digestive symptoms of patient Chang You,
Glutted after feed such as epigastric discomfort, as disease progression Upper abdominal pain aggravates, loss of appetite is out of strength.Late gastric cancer patient often may be used
There is anaemia, thin, malnutritive even cachexia etc. performance.The diffusion and transfer of gastric cancer have following approach: 1. direct invasions:
Cardia stomach bottom cancer easily invades lower esophagus, and gastric cancer can be infiltrated to duodenum.The gastric cancer for breaking up poor infiltrative growth breaks through slurry
After film, nethike embrane, colon, liver, the adjacent organs such as pancreas are easily diffused to.2. hematogenous metastasis: occurring late, it is quiet that cancer cell enters door
Arteries and veins or body circulation are sent out at other positions to body, form transfer stove.The organ of common transfer has a liver, lung, pancreas, bone etc., with
Hepatic metastases is more.3. peritoneal implantation metastasis: after stomach organization is infiltrated to outside serous coat, tumour cell fall off and be planted in peritonaeum and
On internal organs serous coat, Nodules are formed.Peritoneal seeding most easily betides upper abdomen, on mesenterium.Rectum, the plantation at bladder are
The sign of advanced gastric cancer.Recessed metastatic carcinoma, digital rectal examination are can be found that before rectum.Ovarian metastasis can occur for women patients with gastric cancer
Tumour.4. Lymph Node Metastasis: being the main route of metastasis of gastric cancer, the Lymph Node Metastasis rate of advanced gastric carcinoma is up to 70% or so, early stage
Gastric cancer can also have Lymph Node Metastasis.The rate of lymph-node metastasis of gastric cancer and the invasive depth of cancer stove are positively correlated.The lymph of gastric cancer is carried down
It moves typically sequential gradually progressive, but great-jump-forward Lymph Node Metastasis, i.e. first stop can also occur without transfer and second station has transfer.
Operative treatment, chemotherapy, targeted therapy and drug therapy can be used in the treatment method of gastric cancer；Currently used for treating gastric cancer
Curative effect of medication it is general, need further to study.
Summary of the invention
In view of this, the embodiment of the invention provides a kind of drug and preparation method thereof for treating gastric cancer, main purpose is
Solve the problems, such as that the curative effect of drug therapy gastric cancer is little.
In order to achieve the above objectives, invention broadly provides following technical solutions:
On the one hand, the embodiment of the invention provides a kind of drug for treating gastric cancer, the drug includes following parts by weight
Raw material:
30-60 parts of radix pseudostellariae, 30-60 parts of Radix Astragali, 10-20 parts of Radix Glycyrrhizae, 20-30 parts of dendrobium nobile, 10-20 parts of dark plum, stir-baked RADIX PAEONIAE ALBA
15-30 parts, 20-60 parts of Sculellaria barbata, 30-60 parts of mock-strawberry, 10-30 parts of lizard, 10-30 parts of Fructus Aurantii, 3-6 parts of Radix Notoginseng powder, edible tulip
15-30 parts, 30-90 parts of semen coicis, 10-30 parts of radix scutellariae.
Preferably, the drug includes the raw material of following parts by weight: 40-50 parts of radix pseudostellariae, 40-50 parts of Radix Astragali, sweet
It is 15-20 parts careless, 25-30 parts of dendrobium nobile, 15-20 parts of dark plum, 20-30 parts of stir-baked RADIX PAEONIAE ALBA, 30-50 parts of Sculellaria barbata, 40-50 parts of mock-strawberry, lizard
20-30 parts of Yi, 20-30 parts of Fructus Aurantii, 4-6 parts of Radix Notoginseng powder, 20-30 parts of edible tulip, 40-80 parts of semen coicis, 20-30 parts of radix scutellariae.
Preferably, the drug includes the raw material of following parts by weight: 45-50 parts of radix pseudostellariae, 45-50 parts of Radix Astragali, sweet
It is 18-20 parts careless, 28-30 parts of dendrobium nobile, 18-20 parts of dark plum, 25-30 parts of stir-baked RADIX PAEONIAE ALBA, 50-50 parts of Sculellaria barbata, 45-50 parts of mock-strawberry, lizard
25-30 parts of Yi, 25-30 parts of Fructus Aurantii, 5-6 parts of Radix Notoginseng powder, 25-30 parts of edible tulip, 50-70 parts of semen coicis, 25-30 parts of radix scutellariae.
On the other hand, the embodiment of the invention provides the preparation methods of the drug of above-mentioned treatment gastric cancer, comprising the following steps:
Prepare each raw material and crush to be a fine powder by pharmaceutical formulation；
Fine powder obtains secondary fine powder after crossing 150 meshes；
Honey and distilled water are mixed in copper pot according to volume ratio 2:8 and straight fire heats, tender honey is heated to by mild fire refining
Boiling, obtains refined honey after darkening；
By the refined honey, 1:1 is mixed by volume with the secondary fine powder, the agitated ball block for being mixed into dough sample；
The ball block require it is inside and outside all moisten, color is consistent, neither too hard, nor too soft and can random kneading model；
The ball block is made to the smooth spheroidal pill of 10g/ ball, the pill is the drug for treating gastric cancer.
Medicine material effect that the present invention is used to treat gastric cancer is as follows:
Radix pseudostellariae: sweet in flavor, slight bitter；It is mild-natured, have replenish qi to invigorate the spleen, it is promoting production of body fluid and nourishing the lung the effect of.
Radix Astragali: sweet in flavor, tepor, have enhancing body's immunity, liver protection, diuresis, anti-aging, resisting stress, decompression and compared with
Extensive antibacterial action.
Radix Glycyrrhizae: gas is micro-, sweet and special；Major function is clearing heat and detoxicating, expelling phlegm and arresting coughing, stomach duct and abdomen etc..
Dendrobium nobile: nourishing yin and clearing heat diuresis, secretion replenishing and throat moistening.
Stir-baked RADIX PAEONIAE ALBA: contained Paeoniflorin, because of pain caused by acetic acid, there is apparent analgesic activity to human body；Because containing in Radix Glycyrrhizae
Methanol complex also have apparent analgesic activity for this pain, so the two can be with using, effect is more preferable.
Sculellaria barbata: acrid flavour, hardship, it is cold in nature；It is clearing heat and detoxicating, stagnation resolvation diuresis；For furuncle swelling toxin, abscess of throat, the pain of injury caused by falling and tumbling,
Oedema, jaundice, snakebite and bugbite.
Mock-strawberry: sweet in flavor, bitter；Heat-clearing, cool blood are reduced swelling, removing toxic substances.Pyreticosis is controlled, frightened epilepsy is coughed, it spits blood, abscess of throat, dysentery,
Carbuncle swells, furunculosis, snakebite and bugbite, burn.
Lizard: it is salty, it trembles with fear, returns kidney channel, activating microcirculation and removing stasis medicinal, reducing phlegm and resolving masses, diuresis, removing toxic substances calmness." Ningxia Chinese medicinal herbal " is used for bone
Folding, eczema, scrofula, tumour etc..
Radix Notoginseng powder: there is hemostasis, activating microcirculation and removing stasis medicinal, detumescence ding-tong, strengthening by means of tonics, antifatigue, resist oxygen lack, anti-aging, drop blood
Rouge, improves the effects of body's immunity at blood pressure lowering.
Edible tulip: sweet in flavor, micro-pungent, it is cool, there is clearing heat and detoxicating, carbuncle that disappears dissipating bind and other effects, be usually used in carbuncle, swelling and furuncle, scrofula phlegm
Core, snakebite and bugbite, lame lump in the abdomen lump in the abdomen.
Radix scutellariae: being used as medicine with root, bitter, cold in nature, there is heat-clearing and damp-drying drug, purging fire for removing toxin, hemostasis, miscarriage prevention and other effects.
General case-data: in June, 2015 in August, 2017 is 30 male in treating 46 patients with gastric cancer, and female 16,
Age 36~67 years old, the course of disease 1~10.2 year.All cases meet diagnostic criteria, and diagnostic criteria was according to the Ministry of Public Health 2 months 2011 16
It defends day and does " gastric cancer diagnosis and treatment specification (version in 2011) " relevant criterion that (2011) No. 20 publications are sent out in doctor's political affairs.
Compared with prior art, the beneficial effects of the present invention are:
The present invention develops one for gastric cancer illness, treatment medical knowledge, clinical syndrome clustering and many years clinical experience
Pair can be effectively prevented and treated the Chinese medicine preparation of gastric cancer: 30-60 parts of radix pseudostellariae, 30-60 parts of Radix Astragali, and 10-20 parts of Radix Glycyrrhizae, dendrobium nobile
20-30 parts, 10-20 parts of dark plum, 15-30 parts of stir-baked RADIX PAEONIAE ALBA, 20-60 parts of Sculellaria barbata, 30-60 parts of mock-strawberry, 10-30 parts of lizard, Fructus Aurantii
10-30 parts, 3-6 parts of Radix Notoginseng powder, 15-30 parts of edible tulip, 30-90 parts of semen coicis, 10-30 parts of radix scutellariae；Chinese medicine formula is made
Pill simultaneously takes orally, and total effective rate reaches 86.95% or so, has no that significant discomfort is reacted in clinic.Wherein, effective is 26, is had
Effect is 14, and 6 invalid.Therefore, the drug for the treatment of gastric cancer of the invention can be effectively improved the clinical symptoms of gastric cancer, and curative effect is true
It cuts, Small side effects.
Specific embodiment
For further illustrate the present invention to reach the technical means and efficacy that predetermined goal of the invention is taken, below with compared with
Good embodiment, to the specific embodiment applied according to the present invention, technical solution, feature and its effect, detailed description is as follows.Under
The special characteristic in multiple embodiments in bright is stated, structure or feature can be combined by any suitable form.
Embodiment 1
Each medicinal material: radix pseudostellariae 30g, Radix Astragali 30g, Radix Glycyrrhizae 10g are accurately weighed by formula as below, dendrobium nobile 20g, dark plum 10g are fried
Radix Paeoniae Alba 15g, Sculellaria barbata 20g, mock-strawberry 30g, lizard 10g, Fructus Aurantii 10g, Radix Notoginseng powder 3g, edible tulip 15g, semen coicis 30g, radix scutellariae
10g；
By each raw material and crushing is a fine powder, and secondary fine powder is obtained after 150 meshes；Honey and distilled water are pressed
It is mixed in copper pot according to volume ratio 2:8 and tender honey is heated to boiling, obtains refined honey after darkening by straight fire heating, mild fire refining；It will
1:1 is mixed above-mentioned refined honey by volume with above-mentioned secondary fine powder, the agitated ball block for being mixed into dough sample；By above-mentioned ball block
The smooth spheroidal pill of 10g/ ball is made, above-mentioned pill is the drug for treating gastric cancer.
Embodiment 2
Each medicinal material: radix pseudostellariae 40g, Radix Astragali 40g, Radix Glycyrrhizae 15g are accurately weighed by formula as below, dendrobium nobile 25g, dark plum 15g are fried
Radix Paeoniae Alba 20g, Sculellaria barbata 30g, mock-strawberry 40g, lizard 15g, Fructus Aurantii 15g, Radix Notoginseng powder 4g, edible tulip 20g, semen coicis 45g, radix scutellariae
15g；
By each raw material and crushing is a fine powder, and secondary fine powder is obtained after 150 meshes；Honey and distilled water are pressed
It is mixed in copper pot according to volume ratio 2:8 and tender honey is heated to boiling, obtains refined honey after darkening by straight fire heating, mild fire refining；It will
1:1 is mixed above-mentioned refined honey by volume with above-mentioned secondary fine powder, the agitated ball block for being mixed into dough sample；By above-mentioned ball block
The smooth spheroidal pill of 10g/ ball is made, above-mentioned pill is the drug for treating gastric cancer.
Embodiment 3
Each medicinal material: radix pseudostellariae 50g, Radix Astragali 50g, Radix Glycyrrhizae 20g are accurately weighed by formula as below, dendrobium nobile 30g, dark plum 20g are fried
Radix Paeoniae Alba 25g, Sculellaria barbata 40, mock-strawberry 50g, lizard 20g, Fructus Aurantii 20g, Radix Notoginseng powder 5g, edible tulip 25g, semen coicis 60g, radix scutellariae
20g；
By each raw material and crushing is a fine powder, and secondary fine powder is obtained after 150 meshes；Honey and distilled water are pressed
It is mixed in copper pot according to volume ratio 2:8 and tender honey is heated to boiling, obtains refined honey after darkening by straight fire heating, mild fire refining；It will
1:1 is mixed above-mentioned refined honey by volume with above-mentioned secondary fine powder, the agitated ball block for being mixed into dough sample；By above-mentioned ball block
The smooth spheroidal pill of 10g/ ball is made, above-mentioned pill is the drug for treating gastric cancer.
Embodiment 4
Each medicinal material is accurately weighed by formula as below: 60 parts of radix pseudostellariae, 60 parts of Radix Astragali, 20 parts of Radix Glycyrrhizae, 30 parts of dendrobium nobile, dark plum 20
Part, 30 parts of stir-baked RADIX PAEONIAE ALBA, 60 parts of Sculellaria barbata, 60 parts of mock-strawberry, 30 parts of lizard, 30 parts of Fructus Aurantii, 6 parts of Radix Notoginseng powder, 30 parts of edible tulip, coix lacryma-jobi
80 parts of benevolence, 30 parts of radix scutellariae；
By each raw material and crushing is a fine powder, and secondary fine powder is obtained after 150 meshes；Honey and distilled water are pressed
It is mixed in copper pot according to volume ratio 2:8 and tender honey is heated to boiling, obtains refined honey after darkening by straight fire heating, mild fire refining；It will
1:1 is mixed above-mentioned refined honey by volume with above-mentioned secondary fine powder, the agitated ball block for being mixed into dough sample；By above-mentioned ball block
The smooth spheroidal pill of 10g/ ball is made, above-mentioned pill is the drug for treating gastric cancer.
The instructions of taking of drug of the present invention: three times per day, a ball after ten minutes using boiling takes about 30ml mouthfuls of juice
Clothes.Take 15 days as a treatment course.
Clinical efficacy evaluation criteria of the invention: according to " National Standard of the People's Republic of China's tcm clinical practice diagnosis and treatment art
Language syndrome part " GB/T16751.2-1997, " new Chinese medicine guideline of clinical investigations " (China Medical Science Press,
2002) formulate syndrome evaluation criterion
Effective: symptom disappears after treating or symptom integral reduces >=2/3；
Effective: symptom mitigates after treating, and integral reduces >=1/3, < 2/3；
It is invalid: even symptom integrates without exacerbation is mitigated and reduces < 1/3 after treating.
Total effective rate=and (it is effective+effectively)/receive all case loads of the therapy.
Application examples 1
Lee, male 45 years old, suffer from gastric cancer 2 years, and symptom is gasteremphraxis, poor, syntexis of receiving, and dry is defecated partially dry, without obvious mouth
Hardship is slept not good enough, is easily waken up after sleeping, and tongue nature is light dark, and tongue fur is thin white slightly greasy, deep thready pulse；3 Chinese medicine preparation according to embodiments of the present invention, one
Day, a ball after ten minutes using boiling took juice about 30ml oral three times.After taking 2 course for the treatment of, patient's gasteremphraxis, receive it is poor,
Dry, stool be dry and tongue nature it is light it is dark etc. disappear, sleep is obviously improved, and 1 jin of weight gain, check lesion is clearly better.
Application examples 2
Ma, male 76 years old, suffer from gastric cancer 3 years, and symptom is stomach ruffian, stomachache, receive poor out of strength, dry, die Blausucht, sleep
Dream is more, and stool is dry, and tongue nature is light dark, and whitish tongue thickness is greasy.1 Chinese medicine preparation according to embodiments of the present invention, three times per day, a ball is adopted
After ten minutes with boiling, take juice about 30ml oral.After taking 3 course for the treatment of, patient's stomach ruffian, stomachache improve earlier above, and food of receiving increases, still
Feel out of strength；Check lesion is improved.
Application examples 3
Ma, female 65 years old, suffer from gastric cancer 1 year, and symptom is that gastral cavilty portion distending pain is uncomfortable, receive deficiency of food, afternoon and night gastral cavilty portion
More very, spiritlessness and weakness, tongue nature is light dark, and whitish tongue is greasy for turgor；2 Chinese medicine preparation according to embodiments of the present invention, three times per day, one time one
Ball after ten minutes using boiling takes juice about 30ml oral.After taking 2 course for the treatment of, patient's gastral cavilty portion turgor pain relief；Check
Lesion is improved.
Application examples 4
Liu, male 71 years old, suffer from gastric cancer 5 years, and symptom is stomach ruffian, indigestion and loss of appetite out of strength, and sleep dream is more, and pale and tender tongue is with teeth
Trace, whitish tongue.4 Chinese medicine preparation according to embodiments of the present invention, three times per day, a ball after ten minutes using boiling take juice about
30ml is oral.After taking 2 course for the treatment of, patient's stomach ruffian improves earlier above, and feed increases, and still feels out of strength；Check lesion is improved.
The present inventor develops in conjunction with clinical clinical experience over more than 10 years with supplementing qi and nourishing yin, eleminating phlegm and freeing channels effect of detoxifying
Chinese medicine compound prescription.Experimental study show tonifying Qi group radix pseudostellariae, Radix Astragali, Radix Glycyrrhizae group and removing toxic substances eleminating phlegm and freeing channels group Sculellaria barbata, mock-strawberry,
Lizard, Fructus Aurantii, Radix Notoginseng powder, edible tulip, semen coicis drug have the function of stomach cancer cell preferably to promote apoptosis, and conjunction side's group is treated
Effect is best.Tonifying yin group drug also has stomach cancer cell certain inhibiting effect, and organic can help yang-energy, " negatively positive
It helps, biochemical infinite ", and then body's immunity is effectively facilitated, enhance the anticancer effect of Qi-tonifying drug.By to 46 patients with gastric cancer
Healing process observation analysis treats gastric cancer using Chinese medicine of the invention, and most of patients clinical symptoms can be alleviated and be mitigated, and pass through
Treat after 1 course for the treatment of have in 46 26 it is effective, 14 are effectively, and 6 are invalid, and total effective rate reaches 86.95%；Illustrate the present invention
Chinese medicine alleviate gastric cancer malaise symptoms it is effective, and take medicine after without obvious adverse reaction, can clinical expansion.
Place, those skilled in the art can not select from the prior art to the greatest extent in the embodiment of the present invention.
Disclosed above is only a specific embodiment of the invention, but scope of protection of the present invention is not limited thereto, is appointed
What those familiar with the art in the technical scope disclosed by the present invention, can easily think of the change or the replacement, answer
It is included within the scope of the present invention.Therefore, protection scope of the present invention should be with above-mentioned scope of protection of the claims
It is quasi-.
Claims (4)
1. a kind of drug for treating gastric cancer, which is characterized in that the drug includes the raw material of following parts by weight:
30-60 parts of radix pseudostellariae, 30-60 parts of Radix Astragali, 10-20 parts of Radix Glycyrrhizae, 20-30 parts of dendrobium nobile, 10-20 parts of dark plum, stir-baked RADIX PAEONIAE ALBA 15-30
Part, 20-60 parts of Sculellaria barbata, 30-60 parts of mock-strawberry, 10-30 parts of lizard, 10-30 parts of Fructus Aurantii, 3-6 parts of Radix Notoginseng powder, edible tulip 15-30
Part, 30-90 parts of semen coicis, 10-30 parts of radix scutellariae.
2. a kind of drug for treating gastric cancer as described in claim 1, which is characterized in that the drug includes following parts by weight
Raw material: 40-50 parts of radix pseudostellariae, 40-50 parts of Radix Astragali, 15-20 parts of Radix Glycyrrhizae, 25-30 parts of dendrobium nobile, 15-20 parts of dark plum, stir-baked RADIX PAEONIAE ALBA
20-30 parts, 30-50 parts of Sculellaria barbata, 40-50 parts of mock-strawberry, 20-30 parts of lizard, 20-30 parts of Fructus Aurantii, 4-6 parts of Radix Notoginseng powder, edible tulip
20-30 parts, 40-80 parts of semen coicis, 20-30 parts of radix scutellariae.
3. a kind of drug for treating gastric cancer as described in claim 1, which is characterized in that the drug includes following parts by weight
Raw material: 45-50 parts of radix pseudostellariae, 45-50 parts of Radix Astragali, 18-20 parts of Radix Glycyrrhizae, 28-30 parts of dendrobium nobile, 18-20 parts of dark plum, stir-baked RADIX PAEONIAE ALBA
25-30 parts, 50-50 parts of Sculellaria barbata, 45-50 parts of mock-strawberry, 25-30 parts of lizard, 25-30 parts of Fructus Aurantii, 5-6 parts of Radix Notoginseng powder, edible tulip
25-30 parts, 50-70 parts of semen coicis, 25-30 parts of radix scutellariae.
4. a kind of described in any item preparation methods for the drug for treating gastric cancer of claim 1-3, which is characterized in that the method
The following steps are included:
Prepare each raw material and crush to be a fine powder by pharmaceutical formulation；
Fine powder obtains secondary fine powder after crossing 150 meshes；
Honey and distilled water are mixed in copper pot according to volume ratio 2:8 and straight fire heats, tender honey is heated to boiling by mild fire refining,
Refined honey is obtained after darkening；
By the refined honey, 1:1 is mixed by volume with the secondary fine powder, the agitated ball block for being mixed into dough sample；
The ball block is made to the smooth spheroidal pill of 10g/ ball, the pill is the drug for treating gastric cancer.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110269869A (en) * | 2019-07-30 | 2019-09-24 | 宁夏医科大学 | A kind of anti-tumor drug and verification method based on lizard |
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Application publication date: 20181207 |