CN108938822A - A kind of sachalin rhodiola rhizome oral solution and preparation method thereof - Google Patents
A kind of sachalin rhodiola rhizome oral solution and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of sachalin rhodiola rhizome oral solution and preparation method thereof, the sachalin rhodiola rhizome oral solution includes: 50-70 parts of root of kirilow rhodiola, 100-120 parts of Chinese ixora root, 1-2 parts of potassium sorbate, 50-70 parts of honey, 3-5 parts of rose hip, 10-20 parts of gynostemma pentaphylla, 2-4 parts of ganoderma lucidum, 3-5 parts of herba lysimachiae, 10-20 parts of Radix Notoginseng, 0.5-1 parts of menthol, 5-10 parts of fructus lycii, 20-40 parts of egg white, 1-2 parts of aqueous citric acid solution, 3-5 parts of ethylmaltol aqueous solution, 0.2-0.4 parts of caramel colorant according to the raw material of parts by weight.The present invention has effects that supplementing qi and nourishing yin, promoting blood circulation, Rhodiola root oral liquid obtained has root of kirilow rhodiola natural faint scent gas, sweet mouthfeel is soft, unique flavor, is easy to absorb, takes safety pure and fresh tasty and refreshing, full of nutrition, efficacy stability, with very high medical care effect, for spiritlessness and weakness caused by deficiency of both qi and yin, congestion blood block, deficiency of QI with disinclination to talk, insomnia forgetfulness, the symptoms such as have a dizzy spell.
Description
Technical field
The present invention relates to a kind of traditional Chinese medicine oral liquid, specifically a kind of sachalin rhodiola rhizome oral solution and preparation method thereof.
Background technique
With the quickening of modern life rhythm, the aggravation of social competition, the pressure and environmental pollution of work and study in addition
Influence, fatigue and anoxic have become threaten health of people major issue, it is civil to commonly use root of kirilow rhodiola to decoct water or steep in wine, to disappear
Except tired or resistance mountain area is cold.Also diseases prevention is healthy and strong simultaneously and nourishing lengthens one's life, because of its strengthening healthy qi, benefiting qi and nourishing blood, enriching yin benefit lung
Magical effect, in order to improve body fatigue resistance, resist oxygen lack and immune ability, physique of keeping fit delays senescence, and extends life
Life, then pursues some health foods and health medicine, it has also become fashion, especially using root of kirilow rhodiola as prepared by primary raw material
Health care product is even more to be favored.
Sachalin rhodiola rhizome, be the rare rare species of Changbai Mountain in China cold region be raw material, because sachalin rhodiola rhizome include it is rich
Rich rhodioloside and to a tyrosol, furthermore still contains a variety of amino acid, multivitamin, and have the microelement of bioactivity
The compounds such as iron, aluminium, zinc, cobalt, cadmium, titanium, molybdenum, manganese and starch, protein.It can be described as " human nutrition ingredient library ", be known as " high
The good reputation of protoplast's ginseng ".Rhodiola active ingredient is extracted, the other confactors of compatibility can be made into the guarantor of unique flavor, good mouthfeel
Health-care oral liquid.
Oral solution huge number now, but oral solution is largely simple with medicinal plant or fruit in the prior art
Processing is formulated, and clarity is poor or is also easy to produce precipitating.
Summary of the invention
The purpose of the present invention is to provide a kind of anti-aging, the sachalin rhodiola rhizome oral solution of supplementing qi and nourishing yin and its preparation sides
Method, to solve the problems mentioned in the above background technology.
To achieve the above object, the invention provides the following technical scheme:
A kind of sachalin rhodiola rhizome oral solution, the raw material according to parts by weight include: 50-70 parts of root of kirilow rhodiola, Chinese ixora root 100-120
Part, 1-2 parts of potassium sorbate, 50-70 parts of honey, 3-5 parts of rose hip, 10-20 parts of gynostemma pentaphylla, 2-4 parts of ganoderma lucidum, 3-5 parts of herba lysimachiae,
10-20 parts of Radix Notoginseng, 0.5-1 parts of menthol, 5-10 parts of fructus lycii, 20-40 parts of egg white, 1-2 parts of aqueous citric acid solution, ethyl malt
3-5 parts of phenol aqueous solution, 0.2-0.4 parts of caramel colorant.
As a further solution of the present invention: the sachalin rhodiola rhizome oral solution, the raw material according to parts by weight include: red scape
Its 55-65 parts, 105-115 parts of Chinese ixora root, 1.2-1.8 parts of potassium sorbate, 55-65 parts of honey, 3.5-4.5 parts of rose hip, strand
Stock 12-18 parts of indigo plant, 2.5-3.5 parts of ganoderma lucidum, 3.5-4.5 parts of herba lysimachiae, 12-18 parts of Radix Notoginseng, 0.6-0.9 parts of menthol, fructus lycii
6-9 parts, 25-35 parts of egg white, 1.2-1.8 parts of aqueous citric acid solution, 3.5-4.5 parts of ethylmaltol aqueous solution, caramel colorant
0.25-0.35 parts.
As further scheme of the invention: the sachalin rhodiola rhizome oral solution, the raw material according to parts by weight include: red
60 parts of red-spotted stonecrop, 110 parts of Chinese ixora root, 1.5 parts of potassium sorbate, 60 parts of honey, 4 parts of rose hip, 15 parts of gynostemma pentaphylla, 3 parts of ganoderma lucidum, gold
Money grass 4 parts, 15 parts of Radix Notoginseng, 0.8 part of menthol, 8 parts of fructus lycii, 30 parts of egg white, 1.5 parts of aqueous citric acid solution, ethylmaltol
4 parts of aqueous solution, 0.3 part of caramel colorant.
The preparation method of the sachalin rhodiola rhizome oral solution, the specific steps are as follows:
(1) each raw material is weighed according to parts by weight;
(2) root of kirilow rhodiola is cleaned, is sliced, is put into closed extractor, adds 3-5 times to measure water, about 4-6h is leached in 85-95 DEG C of water
It is then allowed to stand 0.5-1h, high-pressure filteration, filtrate is by decompression thin film evaporation concentration twice, and thickening temperature is respectively 120- twice
140 DEG C, 90-110 DEG C obtain root of kirilow rhodiola medicinal extract;
(3) 40-60min will be impregnated respectively after rose hip and gynostemma pentaphylla cleaning, the rose hip and gynostemma pentaphylla after immersion divide three respectively
The water of 8-12 times of weight is added in secondary decoction for the first time, decocts 1.5-2.5h, and the water of 6-10 times of weight is added in filtering for the second time, decocts
0.5-1.5h to be boiled, is filtered, the water of 4-6 times of weight is added in third time, decocts 0.5-1.5 hours, and normal pressure controls 80 DEG C, it filters, point
Do not merge filtrate three times, is concentrated to get rose hip extract and Herb Gynostemmae Pentaphylli extract that relative density is 1.10-1.30;
(4) 50-70min is impregnated after cleaning ganoderma lucidum, is decocted in three times, the water of 12-16 times of weight is added for the first time, decocts 1.5-
2.5h filtering, the water of 5-7 times of weight of second of addition decoct 1.5-2.5h, filtering, and the water of 2-4 times of weight is added in third time, pan-fried
0.5-1.5h is boiled, normal pressure controls 80 DEG C, and filtering merges filtrate three times, is concentrated into the ganoderma lucidum that relative density is 1.10-1.30 and extracts
Object;
(5) decocting is added to endure 1-3h herba lysimachiae and fructus lycii, precipitating filtration takes stevia rebaudianum and fructus lycii supernatant, spare;
(6) Radix Notoginseng is ground into 40-80 mesh powder, purification by liquid extraction obtains Radix Notoginseng supernatant, spare;
(7) concentration is added water to as 15-25% after refined honey, honey and Chinese ixora root mixing, and 10-20 parts of water, is quickly stirred in egg white
Foam is mixed out, egg white is added while stirring, root of kirilow rhodiola medicinal extract, rose hip extract, Herb Gynostemmae Pentaphylli extract, ganoderma lucidum is added and extracts
Object, stevia rebaudianum and fructus lycii supernatant, Radix Notoginseng supernatant, stir evenly, and heating skims offscum after boiling, until without offscum, mistake
Filter;
(8) in the filtrate obtained, potassium sorbate, menthol and aqueous citric acid solution is added in sequence, is filtered after mixing evenly;
(9) clarity for detecting filtrate is down to 20-25 DEG C to solution temperature, and ethylmaltol aqueous solution, burnt sugar coloring is added in sequence
Element, it is filling after the indexs such as sour-sweet degree, color, clarity are qualified to obtain into after filtering plus water constant volume after stirring
Product.
Compared with prior art, the beneficial effects of the present invention are:
The present invention has effects that supplementing qi and nourishing yin, promoting blood circulation, Rhodiola root oral liquid obtained have root of kirilow rhodiola natural faint scent gas, mouthfeel
Sour-sweet soft, unique flavor, is easy to absorb, takes safety pure and fresh tasty and refreshing, full of nutrition, efficacy stability, has very high medical treatment
Health-care effect, for spiritlessness and weakness caused by deficiency of both qi and yin, congestion blood block, deficiency of QI with disinclination to talk, insomnia forgetfulness, the diseases such as have a dizzy spell
Shape.
Specific embodiment
The technical solution of the patent is explained in further detail With reference to embodiment.
Embodiment 1
A kind of sachalin rhodiola rhizome oral solution, the raw material according to parts by weight include: 50 parts of root of kirilow rhodiola, 100 parts of Chinese ixora root, sorbic acid
1 part of potassium, 50 parts of honey, 3 parts of rose hip, 10 parts of gynostemma pentaphylla, 2 parts of ganoderma lucidum, 3 parts of herba lysimachiae, 10 parts of Radix Notoginseng, 0.5 part of menthol, Chinese holly
5 parts of matrimony vine, 20 parts of egg white, 1 part of aqueous citric acid solution, 3 parts of ethylmaltol aqueous solution, 0.2 part of caramel colorant.
The preparation method of the sachalin rhodiola rhizome oral solution, the specific steps are as follows:
(1) each raw material is weighed according to parts by weight;
(2) root of kirilow rhodiola is cleaned, is sliced, is put into closed extractor, adds 3 times of amount water, it is then quiet that about 4h is leached in 85 DEG C of water
0.5h is set, high-pressure filteration, for filtrate by decompression thin film evaporation concentration twice, thickening temperature is respectively 120 DEG C, 90 DEG C twice, is obtained
To root of kirilow rhodiola medicinal extract;
(3) 40min will be impregnated respectively after rose hip and gynostemma pentaphylla cleaning, the rose hip and gynostemma pentaphylla after immersion are decocted in three times respectively
It boiling, the water of 8 times of weight, decoction 1.5h is added for the first time, the water of 6 times of weight is added for the second time, decocts 0.5h, filters for filtering, the
The water of 4 times of weight is added three times, decocts 0.5 hour, normal pressure controls 80 DEG C, and filtering merges filtrate three times respectively, is concentrated to get phase
The rose hip extract and Herb Gynostemmae Pentaphylli extract for being 1.10 to density;
(4) 50min is impregnated after cleaning ganoderma lucidum, is decocted in three times, the water of 12 times of weight is added for the first time, decocts 1.5h filtering,
The water of second of addition, 5 times of weight, decocts 1.5h, filtering, and the water of 2 times of weight, decoction 0.5h, normal pressure control 80 is added in third time
DEG C, filtering merges filtrate three times, is concentrated into the Ganodenna Lucidum P.E that relative density is 1.10;
(5) decocting is added to endure 1h herba lysimachiae and fructus lycii, precipitating filtration takes stevia rebaudianum and fructus lycii supernatant, spare;
(6) Radix Notoginseng is ground into 40 mesh powders, purification by liquid extraction obtains Radix Notoginseng supernatant, spare;
(7) adding water to concentration after refined honey, honey and Chinese ixora root mixing is 15%, and 10 parts of water, quickly stirs blebbing in egg white
Egg white is added in foam while stirring, adds root of kirilow rhodiola medicinal extract, rose hip extract, Herb Gynostemmae Pentaphylli extract, Ganodenna Lucidum P.E, sweet tea
Chrysanthemum and fructus lycii supernatant, Radix Notoginseng supernatant, stir evenly, and heating skims offscum after boiling, until without offscum, filtering;
(8) in the filtrate obtained, potassium sorbate, menthol and aqueous citric acid solution is added in sequence, is filtered after mixing evenly;
(9) clarity for detecting filtrate is down to 20 DEG C to solution temperature, and ethylmaltol aqueous solution, caramel colorant is added in sequence,
It is filling after the indexs such as sour-sweet degree, color, clarity are qualified to obtain finished product after filtering plus water constant volume after stirring.
Instructions of taking: oral a, 10mL, twice a day.
Embodiment 2
A kind of sachalin rhodiola rhizome oral solution, the raw material according to parts by weight include: 55 parts of root of kirilow rhodiola, 105 parts of Chinese ixora root, sorbic acid
1.2 parts of potassium, 55 parts of honey, 3.5 parts of rose hip, 12 parts of gynostemma pentaphylla, 2.5 parts of ganoderma lucidum, 3.5 parts of herba lysimachiae, 12 parts of Radix Notoginseng, menthol
0.6 part, 6 parts of fructus lycii, 25 parts of egg white, 1.2 parts of aqueous citric acid solution, 3.5 parts of ethylmaltol aqueous solution, caramel colorant 0.25
Part.
The preparation method of the sachalin rhodiola rhizome oral solution, the specific steps are as follows:
(1) each raw material is weighed according to parts by weight;
(2) root of kirilow rhodiola is cleaned, is sliced, is put into closed extractor, adds 3.5 times of amount water, it is right to leach about 4.5h in 88 DEG C of water
After stand 0.6h, high-pressure filteration, filtrate is by decompression thin film evaporation concentration twice, and thickening temperature is respectively 125 DEG C, 95 twice
DEG C, obtain root of kirilow rhodiola medicinal extract;
(3) 45min will be impregnated respectively after rose hip and gynostemma pentaphylla cleaning, the rose hip and gynostemma pentaphylla after immersion are decocted in three times respectively
It boiling, the water of 9 times of weight, decoction 1.8h is added for the first time, the water of 7 times of weight is added for the second time, decocts 0.8h, filters for filtering, the
The water of 4.5 times of weight is added three times, decocts 0.8 hour, normal pressure controls 80 DEG C, and filtering merges filtrate three times respectively, is concentrated to get
The rose hip extract and Herb Gynostemmae Pentaphylli extract that relative density is 1.15;
(4) 55min is impregnated after cleaning ganoderma lucidum, is decocted in three times, the water of 13 times of weight is added for the first time, decocts 1.8h filtering,
The water of second of addition, 5.5 times of weight, decocts 1.8h, filtering, and the water of 2.5 times of weight, decoction 0.8h, normal pressure control is added in third time
80 DEG C of system, filtering merge filtrate three times, are concentrated into the Ganodenna Lucidum P.E that relative density is 1.15;
(5) decocting is added to endure 1.5h herba lysimachiae and fructus lycii, precipitating filtration takes stevia rebaudianum and fructus lycii supernatant, spare;
(6) Radix Notoginseng is ground into 50 mesh powders, purification by liquid extraction obtains Radix Notoginseng supernatant, spare;
(7) adding water to concentration after refined honey, honey and Chinese ixora root mixing is 18%, and 12 parts of water, quickly stirs blebbing in egg white
Egg white is added in foam while stirring, adds root of kirilow rhodiola medicinal extract, rose hip extract, Herb Gynostemmae Pentaphylli extract, Ganodenna Lucidum P.E, sweet tea
Chrysanthemum and fructus lycii supernatant, Radix Notoginseng supernatant, stir evenly, and heating skims offscum after boiling, until without offscum, filtering;
(8) in the filtrate obtained, potassium sorbate, menthol and aqueous citric acid solution is added in sequence, is filtered after mixing evenly;
(9) clarity for detecting filtrate is down to 21 DEG C to solution temperature, and ethylmaltol aqueous solution, caramel colorant is added in sequence,
It is filling after the indexs such as sour-sweet degree, color, clarity are qualified to obtain finished product after filtering plus water constant volume after stirring.
Instructions of taking: oral a, 10-20mL, twice a day.
Embodiment 3
A kind of mountain Rhodiola root oral liquid, the raw material according to parts by weight include: 60 parts of root of kirilow rhodiola, 110 parts of Chinese ixora root, potassium sorbate
1.5 parts, 60 parts of honey, 4 parts of rose hip, 15 parts of gynostemma pentaphylla, 3 parts of ganoderma lucidum, 4 parts of herba lysimachiae, 15 parts of Radix Notoginseng, 0.8 part of menthol, Chinese holly
8 parts of matrimony vine, 30 parts of egg white, 1.5 parts of aqueous citric acid solution, 4 parts of ethylmaltol aqueous solution, 0.3 part of caramel colorant.
The preparation method of the sachalin rhodiola rhizome oral solution, the specific steps are as follows:
(1) each raw material is weighed according to parts by weight;
(2) root of kirilow rhodiola is cleaned, is sliced, is put into closed extractor, adds 4 times of amount water, it is then quiet that about 5h is leached in 90 DEG C of water
0.8h is set, high-pressure filteration, for filtrate by decompression thin film evaporation concentration twice, thickening temperature is respectively 130 DEG C, 100 DEG C twice, is obtained
To root of kirilow rhodiola medicinal extract;
(3) 50min will be impregnated respectively after rose hip and gynostemma pentaphylla cleaning, the rose hip and gynostemma pentaphylla after immersion are decocted in three times respectively
It boils, the water of 10 times of weight is added for the first time, decoct 2h, the water of 8 times of weight is added in filtering for the second time, decocts 1h, filtering, third
The secondary water that 5 times of weight is added, decocts 1 hour, and normal pressure controls 80 DEG C, and filtering merges filtrate three times respectively, is concentrated to get relatively close
The rose hip extract and Herb Gynostemmae Pentaphylli extract that degree is 1.20;
(4) 60min is impregnated after cleaning ganoderma lucidum, is decocted in three times, the water of 14 times of weight is added for the first time, decocts 2h filtering, the
The secondary water that 6 times of weight is added decocts 2h, filtering, and the water of 3 times of weight is added in third time, decocts 1h, and normal pressure controls 80 DEG C, mistake
Filter merges filtrate three times, is concentrated into the Ganodenna Lucidum P.E that relative density is 1.20;
(5) decocting is added to endure 2h herba lysimachiae and fructus lycii, precipitating filtration takes stevia rebaudianum and fructus lycii supernatant, spare;
(6) Radix Notoginseng is ground into 60 mesh powders, purification by liquid extraction obtains Radix Notoginseng supernatant, spare;
(7) adding water to concentration after refined honey, honey and Chinese ixora root mixing is 20%, and 15 parts of water, quickly stirs blebbing in egg white
Egg white is added in foam while stirring, adds root of kirilow rhodiola medicinal extract, rose hip extract, Herb Gynostemmae Pentaphylli extract, Ganodenna Lucidum P.E, sweet tea
Chrysanthemum and fructus lycii supernatant, Radix Notoginseng supernatant, stir evenly, and heating skims offscum after boiling, until without offscum, filtering;
(8) in the filtrate obtained, potassium sorbate, menthol and aqueous citric acid solution is added in sequence, is filtered after mixing evenly;
(9) clarity for detecting filtrate is down to 22 DEG C to solution temperature, and ethylmaltol aqueous solution, caramel colorant is added in sequence,
It is filling after the indexs such as sour-sweet degree, color, clarity are qualified to obtain finished product after filtering plus water constant volume after stirring.
Instructions of taking: oral a, 10-20mL, twice a day.
Embodiment 4
A kind of sachalin rhodiola rhizome oral solution, the raw material according to parts by weight include: 65 parts of root of kirilow rhodiola, 115 parts of Chinese ixora root, sorbic acid
1.8 parts of potassium, 65 parts of honey, 4.5 parts of rose hip, 18 parts of gynostemma pentaphylla, 3.5 parts of ganoderma lucidum, 4.5 parts of herba lysimachiae, 18 parts of Radix Notoginseng, menthol
0.9 part, 9 parts of fructus lycii, 35 parts of egg white, 1.8 parts of aqueous citric acid solution, 4.5 parts of ethylmaltol aqueous solution, caramel colorant 0.35
Part.
The preparation method of the sachalin rhodiola rhizome oral solution, the specific steps are as follows:
(1) each raw material is weighed according to parts by weight;
(2) root of kirilow rhodiola is cleaned, is sliced, is put into closed extractor, adds 4.5 times of amount water, it is right to leach about 5.5h in 92 DEG C of water
After stand 0.9h, high-pressure filteration, filtrate is by decompression thin film evaporation concentration twice, and thickening temperature is respectively 135 DEG C, 105 twice
DEG C, obtain root of kirilow rhodiola medicinal extract;
(3) 55min will be impregnated respectively after rose hip and gynostemma pentaphylla cleaning, the rose hip and gynostemma pentaphylla after immersion are decocted in three times respectively
It boiling, the water of 11 times of weight, decoction 2.2h is added for the first time, the water of 9 times of weight is added for the second time, decocts 1.2h, filters for filtering,
The water of 5.5 times of weight is added in third time, decocts 1.2 hours, and normal pressure controls 80 DEG C, and filtering merges filtrate three times respectively, is concentrated to give
The rose hip extract and Herb Gynostemmae Pentaphylli extract for being 1.25 to relative density;
(4) 65in is impregnated after cleaning ganoderma lucidum, is decocted in three times, the water of 15 times of weight is added for the first time, decocts 2.2h filtering, the
The secondary water that 6.5 times of weight is added decocts 2.2h, filtering, and the water of 3.5 times of weight is added in third time, decocts 1.2h, normal pressure control
80 DEG C, filtering merges filtrate three times, is concentrated into the Ganodenna Lucidum P.E that relative density is 1.25;
(5) decocting is added to endure 2.5h herba lysimachiae and fructus lycii, precipitating filtration takes stevia rebaudianum and fructus lycii supernatant, spare;
(6) Radix Notoginseng is ground into 70 mesh powders, purification by liquid extraction obtains Radix Notoginseng supernatant, spare;
(7) adding water to concentration after refined honey, honey and Chinese ixora root mixing is 22%, and 18 parts of water, quickly stirs blebbing in egg white
Egg white is added in foam while stirring, adds root of kirilow rhodiola medicinal extract, rose hip extract, Herb Gynostemmae Pentaphylli extract, Ganodenna Lucidum P.E, sweet tea
Chrysanthemum and fructus lycii supernatant, Radix Notoginseng supernatant, stir evenly, and heating skims offscum after boiling, until without offscum, filtering;
(8) in the filtrate obtained, potassium sorbate, menthol and aqueous citric acid solution is added in sequence, is filtered after mixing evenly;
(9) clarity for detecting filtrate is down to 24 DEG C to solution temperature, and ethylmaltol aqueous solution, caramel colorant is added in sequence,
It is filling after the indexs such as sour-sweet degree, color, clarity are qualified to obtain finished product after filtering plus water constant volume after stirring.
Instructions of taking: oral a, 10-20mL, twice a day.
Embodiment 5
A kind of sachalin rhodiola rhizome oral solution, the raw material according to parts by weight include: 70 parts of root of kirilow rhodiola, 120 parts of Chinese ixora root, sorbic acid
2 parts of potassium, 70 parts of honey, 5 parts of rose hip, 20 parts of gynostemma pentaphylla, 4 parts of ganoderma lucidum, 5 parts of herba lysimachiae, 20 parts of Radix Notoginseng, 1 part of menthol, fructus lycii
Sub 10 parts, 40 parts of egg white, 2 parts of aqueous citric acid solution, 5 parts of ethylmaltol aqueous solution, 0.4 part of caramel colorant.
The preparation method of the sachalin rhodiola rhizome oral solution, the specific steps are as follows:
(1) each raw material is weighed according to parts by weight;
(2) root of kirilow rhodiola is cleaned, is sliced, is put into closed extractor, adds 5 times of amount water, it is then quiet that about 6h is leached in 95 DEG C of water
1h is set, high-pressure filteration, for filtrate by decompression thin film evaporation concentration twice, thickening temperature is respectively 140 DEG C, 110 DEG C twice, is obtained
Root of kirilow rhodiola medicinal extract;
(3) 60min will be impregnated respectively after rose hip and gynostemma pentaphylla cleaning, the rose hip and gynostemma pentaphylla after immersion are decocted in three times respectively
It boiling, the water of 12 times of weight, decoction 2.5h is added for the first time, the water of 10 times of weight is added for the second time, decocts 1.5h, filters for filtering,
The water of 6 times of weight is added in third time, decocts 1.5 hours, and normal pressure controls 80 DEG C, and filtering merges filtrate three times respectively, is concentrated to get
The rose hip extract and Herb Gynostemmae Pentaphylli extract that relative density is 1.30;
(4) 70min is impregnated after cleaning ganoderma lucidum, is decocted in three times, the water of 16 times of weight is added for the first time, decocts 2.5h filtering,
The water of second of addition, 7 times of weight, decocts 2.5h, filtering, and the water of 4 times of weight, decoction 1.5h, normal pressure control 80 is added in third time
DEG C, filtering merges filtrate three times, is concentrated into the Ganodenna Lucidum P.E that relative density is 1.30;
(5) decocting is added to endure 3h herba lysimachiae and fructus lycii, precipitating filtration takes stevia rebaudianum and fructus lycii supernatant, spare;
(6) Radix Notoginseng is ground into 80 mesh powders, purification by liquid extraction obtains Radix Notoginseng supernatant, spare;
(7) adding water to concentration after refined honey, honey and Chinese ixora root mixing is 25%, and 20 parts of water, quickly stirs blebbing in egg white
Egg white is added in foam while stirring, adds root of kirilow rhodiola medicinal extract, rose hip extract, Herb Gynostemmae Pentaphylli extract, Ganodenna Lucidum P.E, sweet tea
Chrysanthemum and fructus lycii supernatant, Radix Notoginseng supernatant, stir evenly, and heating skims offscum after boiling, until without offscum, filtering;
(8) in the filtrate obtained, potassium sorbate, menthol and aqueous citric acid solution is added in sequence, is filtered after mixing evenly;
(9) clarity for detecting filtrate is down to 25 DEG C to solution temperature, and ethylmaltol aqueous solution, caramel colorant is added in sequence,
It is filling after the indexs such as sour-sweet degree, color, clarity are qualified to obtain finished product after filtering plus water constant volume after stirring.
Instructions of taking: oral a, 10-20mL, twice a day.
The sachalin rhodiola rhizome oral solution be rufous or or brown liquid, gas is fragrant, sweet, slight bitter, puckery.
The relative density of the sachalin rhodiola rhizome oral solution is not less than 1.03, pH value 4.5-6.5, and sachalin rhodiola rhizome is oral
The discrimination method of liquid: taking this product 10ml, and by D101 type large pore resin absorption column, (column internal diameter 1-1.5cm, pillar height 10-15cm are used
Water prewashing), it is eluted with water 40ml, then colourless to eluent with 20% ethanol elution, is eluted after with 70% ethyl alcohol 60ml, collect 70%
Ethanol eluate is evaporated, and residue is dissolved with 70% ethyl alcohol 5ml, is added in neutral alumina column (100-200 mesh, 5g, column internal diameter 1.0-
1.5cm, wet method dress post, with 70% ethyl alcohol prewashing) on, it is eluted with 70% ethyl alcohol 50ml, collects eluent, be evaporated, residue adds methanol
0.5ml makes to dissolve, and as test solution, separately takes sachalin rhodiola rhizome control medicinal material 1g, and add diethyl ether 20ml, low-temperature heat reflux 30
Minute, filtration, the dregs of a decoction volatilize, add 70% ethyl alcohol 25ml, be heated to reflux 1 hour, filter, and filtrate is concentrated to dryness, and residue adds water
20ml sets in hot water and heats, and is stirred to dissolve, cooling, and centrifugation takes supernatant, and the n-butanol shaking being saturated with water is extracted 3 times,
Each 15ml merges n-butanol extracting liquid, is evaporated, and residue is dissolved with 70% ethyl alcohol 5ml, and neutral alumina column (100-200 is added
Mesh, 5g, column internal diameter 1.0-1.5cm, wet method dress post, with 70% ethyl alcohol prewashing) on, it is eluted with 70% ethyl alcohol 50ml, collects eluent,
It is evaporated, residue adds methanol 1ml to make to dissolve, as control medicinal material solution.According to thin-layered chromatography (2010 editions annex of Chinese Pharmacopoeia
VI B) test, each 4 μ 1 of above two solution is drawn, is put respectively on same silica gel g thin-layer plate, with chloroform-ethyl acetate-
10 DEG C of lower layers arranged below of methanol-water (15:40:22:10) are easy to be unfolded for solvent, take out, dry, in ultraviolet light
It is inspected under (24nm).In sample chromatogram, on position corresponding with reference medicine chromatography, the spot of same color is shown.
Assay: high effective liquid chromatography for measuring is shone.
Chromatographic condition and system suitability: using octadecylsilane chemically bonded silica as filler;With -0.1% phosphorus of acetonitrile
Acid solution (6:94) is mobile phase;Detection wavelength is 223nm;Column temperature is 40 DEG C.It is indefinite that number of theoretical plate is calculated by rhodioside peak
In 4000.
The preparation of reference substance solution: taking rhodioside reference substance appropriate, accurately weighed, adds mobile phase that 1ml is made containing 45 μ g
Solution to get.
The preparation of test solution: precision measures this product 10ml, by D101 type macroporous absorbent resin (through 1.5cm in column,
Pillar height 14cm), it is eluted with water 100ml, then eluted with 70% ethyl alcohol 100ml, collects 70% ethanol eluate, be evaporated.Residue stream
Dynamic phased soln is simultaneously transferred in 50mL measuring bottle, is ultrasonically treated (power 100w, frequency 50kHz) 10min, is let cool, add mobile phase extremely
Scale shakes up, filtration, take subsequent filtrate to get.
Measuring method: precision draws reference substance solution and each 5 μ L of test solution, injects liquid chromatograph, measurement to get.
The every 1mL of the present invention contains sachalin rhodiola rhizome in terms of rhodioside, no less than 0.15mg.
The present invention has effects that supplementing qi and nourishing yin, promoting blood circulation, Rhodiola root oral liquid obtained have root of kirilow rhodiola natural faint scent gas,
Sweet mouthfeel is soft, and unique flavor, is easy to absorb, takes safety pure and fresh tasty and refreshing, full of nutrition, efficacy stability, has very high
Medical care effect for spiritlessness and weakness caused by deficiency of both qi and yin, congestion blood block, deficiency of QI with disinclination to talk, insomnia forgetfulness, is had a dizzy spell
Symptom.
The preferred embodiment of the patent is described in detail above, but this patent is not limited to above-mentioned embodiment party
Formula within the knowledge of one of ordinary skill in the art can also be under the premise of not departing from this patent objective
Various changes can be made.
Claims (4)
1. a kind of sachalin rhodiola rhizome oral solution, which is characterized in that the raw material according to parts by weight includes: 50-70 parts of root of kirilow rhodiola, dragon-boat
Flower root 100-120 parts, 1-2 parts of potassium sorbate, 50-70 parts of honey, 3-5 parts of rose hip, 10-20 parts of gynostemma pentaphylla, 2-4 parts of ganoderma lucidum,
3-5 parts of herba lysimachiae, 10-20 parts of Radix Notoginseng, 0.5-1 parts of menthol, 5-10 parts of fructus lycii, 20-40 parts of egg white, aqueous citric acid solution 1-
2 parts, 3-5 parts of ethylmaltol aqueous solution, 0.2-0.4 parts of caramel colorant.
2. sachalin rhodiola rhizome oral solution according to claim 1, which is characterized in that the raw material according to parts by weight includes: red
55-65 parts of red-spotted stonecrop, 105-115 parts of Chinese ixora root, 1.2-1.8 parts of potassium sorbate, 55-65 parts of honey, 3.5-4.5 parts of rose hip,
12-18 parts of gynostemma pentaphylla, 2.5-3.5 parts of ganoderma lucidum, 3.5-4.5 parts of herba lysimachiae, 12-18 parts of Radix Notoginseng, 0.6-0.9 parts of menthol, fructus lycii
6-9 parts sub-, 25-35 parts of egg white, 1.2-1.8 parts of aqueous citric acid solution, 3.5-4.5 parts of ethylmaltol aqueous solution, caramel colorant
0.25-0.35 parts.
3. sachalin rhodiola rhizome oral solution according to claim 1, which is characterized in that the raw material according to parts by weight includes: red
60 parts of red-spotted stonecrop, 110 parts of Chinese ixora root, 1.5 parts of potassium sorbate, 60 parts of honey, 4 parts of rose hip, 15 parts of gynostemma pentaphylla, 3 parts of ganoderma lucidum, gold
Money grass 4 parts, 15 parts of Radix Notoginseng, 0.8 part of menthol, 8 parts of fructus lycii, 30 parts of egg white, 1.5 parts of aqueous citric acid solution, ethylmaltol
4 parts of aqueous solution, 0.3 part of caramel colorant.
4. a kind of preparation method of sachalin rhodiola rhizome oral solution a method according to any one of claims 1-3, which is characterized in that specific step
It is rapid as follows:
(1) each raw material is weighed according to parts by weight;
(2) root of kirilow rhodiola is cleaned, is sliced, is put into closed extractor, adds 3-5 times to measure water, about 4-6h is leached in 85-95 DEG C of water
It is then allowed to stand 0.5-1h, high-pressure filteration, filtrate is by decompression thin film evaporation concentration twice, and thickening temperature is respectively 120- twice
140 DEG C, 90-110 DEG C obtain root of kirilow rhodiola medicinal extract;
(3) 40-60min will be impregnated respectively after rose hip and gynostemma pentaphylla cleaning, the rose hip and gynostemma pentaphylla after immersion divide three respectively
The water of 8-12 times of weight is added in secondary decoction for the first time, decocts 1.5-2.5h, and the water of 6-10 times of weight is added in filtering for the second time, decocts
0.5-1.5h to be boiled, is filtered, the water of 4-6 times of weight is added in third time, decocts 0.5-1.5 hours, and normal pressure controls 80 DEG C, it filters, point
Do not merge filtrate three times, is concentrated to get rose hip extract and Herb Gynostemmae Pentaphylli extract that relative density is 1.10-1.30;
(4) 50-70min is impregnated after cleaning ganoderma lucidum, is decocted in three times, the water of 12-16 times of weight is added for the first time, decocts 1.5-
2.5h filtering, the water of 5-7 times of weight of second of addition decoct 1.5-2.5h, filtering, and the water of 2-4 times of weight is added in third time, pan-fried
0.5-1.5h is boiled, normal pressure controls 80 DEG C, and filtering merges filtrate three times, is concentrated into the ganoderma lucidum that relative density is 1.10-1.30 and extracts
Object;
(5) decocting is added to endure 1-3h herba lysimachiae and fructus lycii, precipitating filtration takes stevia rebaudianum and fructus lycii supernatant, spare;
(6) Radix Notoginseng is ground into 40-80 mesh powder, purification by liquid extraction obtains Radix Notoginseng supernatant, spare;
(7) concentration is added water to as 15-25% after refined honey, honey and Chinese ixora root mixing, and 10-20 parts of water, is quickly stirred in egg white
Foam is mixed out, egg white is added while stirring, root of kirilow rhodiola medicinal extract, rose hip extract, Herb Gynostemmae Pentaphylli extract, ganoderma lucidum is added and extracts
Object, stevia rebaudianum and fructus lycii supernatant, Radix Notoginseng supernatant, stir evenly, and heating skims offscum after boiling, until without offscum, mistake
Filter;
(8) in the filtrate obtained, potassium sorbate, menthol and aqueous citric acid solution is added in sequence, is filtered after mixing evenly;
(9) clarity for detecting filtrate is down to 20-25 DEG C to solution temperature, and ethylmaltol aqueous solution, burnt sugar coloring is added in sequence
Element, it is filling after the indexs such as sour-sweet degree, color, clarity are qualified to obtain into after filtering plus water constant volume after stirring
Product.
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