CN108935697A - It is a kind of for preventing the alimentation composition of infantile eczema - Google Patents
It is a kind of for preventing the alimentation composition of infantile eczema Download PDFInfo
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- CN108935697A CN108935697A CN201811056697.9A CN201811056697A CN108935697A CN 108935697 A CN108935697 A CN 108935697A CN 201811056697 A CN201811056697 A CN 201811056697A CN 108935697 A CN108935697 A CN 108935697A
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- alimentation composition
- oligosaccharides
- lactose
- hydrolysate
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/156—Flavoured milk preparations ; Addition of fruits, vegetables, sugars, sugar alcohols or sweeteners
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
- A23C9/1526—Amino acids; Peptides; Protein hydrolysates; Nucleic acids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/16—Agglomerating or granulating milk powder; Making instant milk powder; Products obtained thereby
Abstract
The present invention provides a kind of for preventing the alimentation composition of infantile eczema, by total weight be 100 parts by weight in terms of, which includes: alpha lactalbumin and/or 0.2-45 parts of 10-30 parts of 20-55 parts of its hydrolysate, beta-casein and/or its hydrolysate, human milk oligosaccharides and/or its precursor, 5-10 parts of dietary fiber.The present invention also provides application of the above-mentioned alimentation composition in the composition that preparation has prevention infantile eczema effect.The present invention also provides a kind of children's food, and it includes above-mentioned for preventing the alimentation composition of infantile eczema.Alimentation composition provided by the invention is suitable for reducing infantile eczema risk.By the way that human milk oligosaccharides (HMOs) and multiple nutritional components science arrange in pairs or groups, it is prepared into corresponding alimentation composition, is intervened by food feeding, the risk that children suffer from eczema can be significantly reduced, and then realize the effect of infantile eczema early prevention.
Description
Technical field
The present invention relates to infant nutrition field of health care food, and in particular to one kind can prevent the nutrition group of infantile eczema risk
Close object.
Background technique
Planning commission is defended according to country announcing data and show, (international average is 0-6 month baby Pure breast feeding rate for 27.8%
38%), wherein rural area 30.3%, city 15.8%.And in 1998, Chinese breastfeeding rate is also in 67%.In recent years
Come, as " breast-feeding is good " propagates and educates wide-scale distribution, mother's breastfeeding rate after 90s is continuously improved, but still far below China
The target for 50% feeding rate that Action for Child Development determines.It is numerous studies have shown that breast-feeding and non-breastfeeding baby, remote
Phase disease risk has significant difference, as the baby of non-breastfeeding is easier to suffer from eczema.
Eczematosis because be it is various, the cause of disease is complex, carefully analyzes in conjunction with each infant, generally has heredity to incline
It is prone to suffer from eczema to allergic constitution.The cause of disease is related with protein diet, and sufferer is based on children, especially 6-12 monthly age
Children, disease incidence are up to 75%, and are in cumulative year after year trend.When initial stage falls ill, mostly distribute or the small red pimple or red of cluster
Spot gradually increases, and visible vesicle.If eczema infant fails to be easy to induce infection, and the state of an illness is anti-by timely diagnosis and treatment
Recurrence is made, and the healthy growth of children is seriously affected.It is clinically main that eczema infant is treated by Claritin, and keep skin
Impaired face drying etc., however the therapeutic effect of many infants is unsatisfactory.It is reported that the morbidity of eczema infant and internal enterobacteriaceae
Group is unbalance in close relations.This common children's susceptible disease, usually annoyings parent.It is directed to the control method of infantile eczema at present
It has been reported that, the method for clinical use is also more diversified, but still falls within relieving symptoms, can not thoroughly eradicate more.
Summary of the invention
To solve the above problems, the purpose of the present invention is to provide a kind of alimentation composition for preventing baby diarrhea disease,
By being prepared into human milk oligosaccharides (HMOs) and the collocation of multiple nutritional components science alimentation composition, being intervened by food feeding,
The risk that children suffer from eczema can be significantly reduced.
In order to achieve the above objectives, the present invention provides a kind of for preventing the alimentation composition of infantile eczema, with total weight
For 100 parts by weight meters, which includes: 20-55 parts of alpha lactalbumin and/or its hydrolysate, beta-casein and/or
0.2-45 parts of 10-30 parts of its hydrolysate, human milk oligosaccharides and/or its precursor, 5-10 parts of dietary fiber.
In above-mentioned alimentation composition, it is preferable that the content of the beta-casein and/or its hydrolysate is 15-25 parts.
Alimentation composition of the invention can be made to the preventive and therapeutic action of eczema by the way that beta-casein and/or its hydrolysate is added
Significant effect is promoted.
In above-mentioned alimentation composition, alpha lactalbumin and beta-casein are capable of forming point after internal or external hydrolyze
Son amount is less than the peptide chain of 5kD, is combined with dietary fiber (oligosaccharide), acts on body, accelerates inflammation rapid regression, and then play
The effect of prevention and treatment eczema.Preferably, the alpha lactalbumin and/or its hydrolysate and beta-casein and/or its water
The mass ratio for solving product is=1:2-3:1；Preferably 2:1.
In above-mentioned alimentation composition, alpha lactalbumin and beta-casein are subjected to appropriateness or depth hydrolysis, it can be made
Baby suitable for protein allergies and potential protein allergies, it is preferable that the degree of hydrolysis DH of the alpha lactalbumin and beta-casein
It is 8 or more, preferably 10-50, more preferably 20-40.
In above-mentioned alimentation composition, HMO or HMOs primarily serve booster action, with alpha lactalbumin and beta-casein one
It rises, acts synergistically on body, reduce infantile eczema onset risk.Preferably, the human milk oligosaccharides and/or its precursor include: acid
One of property oligosaccharides, neutral oligosaccharides, N- acetyl glucosamine oligosaccharides and human milk oligosaccharides precursor or a variety of combinations, also, extremely
It less include a kind of neutral oligosaccharides.It is highly preferred that the human milk oligosaccharides and/or its precursor include acidic oligosaccharide and neutral oligosaccharides, and
And the mass ratio 1:4-1:2 of the two.Inventor, which studies, to be found: the alimentation composition and acidic oligosaccharide of acidic oligosaccharide individualism/
The alimentation composition that neutral oligosaccharides are composed, there are larger difference, the effects of combination, and acidity is relatively used alone for effect
The better effect of oligosaccharides.
In above-mentioned alimentation composition, it is preferable that the acidic oligosaccharide includes the oligomeric of sialic acid and/or sulfate structure
Sugar, more preferably include sialylated-sialylated lactose of lacto-N-tetraose c, 6'-, the sialylated lactose of 3'-, it is sialylated-
The combination of one or more of lacto-N-tetraose a, sialylated-lacto-N-tetraose b and two sialic acids-lacto-N-tetraose.
In above-mentioned alimentation composition, it is preferable that the neutral oligosaccharides include the oligosaccharide and/or kukersite of no fucosido
The oligosaccharide of algae glycosyl more preferably includes 2'- fucosyllactose, 3'- fucosyllactose, 2', 3- fucosyllactose, cream
The new tetrose of acyl-N-, lacto-N-fucopentaose -1, lacto-N-fucopentaose -2, lacto-N-fucopentaose -3 and lactoyl-N- two
The combination of one or more of six sugar -1 of rock algae.
In above-mentioned alimentation composition, it is preferable that the human milk oligosaccharides and/or its precursor include sialic acid (SA), 3 '-salivas
Liquid yogurt sugar (3 ' SL), 6 '-sialyl lactoses (6 ' SL), 2'-Fucosyl lactose (2 ' FL), 3 '-fucosyllactoses (3 '
FL), the combination of one or more of lacto-N-neotetraose (LNnT) and two sialyl lactose-N- tetroses (DSLNT) etc..
In above-mentioned alimentation composition, the dietary fiber refers to the dietary fiber other than human milk oligosaccharides, it is preferable that
The dietary fiber includes one of oligofructose, beta glucan, polydextrose and isomerizing lactose or a variety of combinations.
In above-mentioned alimentation composition, it is preferable that the total weight of the alimentation composition is 100 parts by weight, with fat, carbon water
The combination polishing of one or more of compound, minerals, vitamin and water.
Specific embodiment according to the present invention, by total weight be 100 parts by weight in terms of, which includes: α-cream
Albumin and/or 10-30 parts of 20-55 parts of its hydrolysate, beta-casein and/or its hydrolysate, human milk oligosaccharides and/or its before
0-45 parts of body, 5-10 parts of dietary fiber, surplus are one or more of fat, carbohydrate, minerals, vitamin and water
Combination.
The present invention also provides application of the alimentation composition in the composition that preparation has prevention infantile eczema effect.
The present invention also provides a kind of children's food, and it includes above-mentioned for preventing the alimentation composition of infantile eczema；It is excellent
Selection of land, the food are children's formula milk.Alimentation composition of the invention, which can be liquid formulation also, to be solid formulation, may be used also
To be made an addition in other children's food with special ratios, as in liquid form in children's formula milk.The nutrition of food
It is that children parent selects children's formula food to consider the problems of that more and more parents rely in breast milk often with safety problem
Children's formula food.Children's food of the invention can either pack the nutritional need of children, and have good safety.
Children according to the present invention include 12 years old newborn, infant and children below.
Alimentation composition provided by the invention is suitable for reducing infantile eczema risk.By by human milk oligosaccharides and a variety of nutrition
The collocation of ingredient science, is prepared into corresponding alimentation composition, is intervened by food feeding, can significantly reduce children and suffer from eczema
Risk, and then realize infantile eczema early prevention effect.
Specific embodiment
In order to which technical characteristic of the invention, purpose and beneficial effect are more clearly understood, now to skill of the invention
Art scheme carries out described further below, but should not be understood as that limiting the scope of the invention.
Embodiment 1
Present embodiments provide a kind of alimentation composition for preventing infantile eczema, by total weight be 100 parts by weight in terms of, the battalion
Feeding composition include: hydrolysis 40 parts of alpha lactalbumin (degree of hydrolysis DH be 20), hydrolyze 25 parts of beta-casein (degree of hydrolysis DH is 15),
30 parts of human milk oligosaccharides (10 parts of sialic acid, 20 parts of 3 '-fucosyllactose), 5 parts of oligofructose.
Embodiment 2
Present embodiments provide a kind of alimentation composition for preventing infantile eczema, by total weight be 100 parts by weight in terms of, the battalion
Feeding composition include: hydrolysis 20 parts of alpha lactalbumin (degree of hydrolysis DH be 50), hydrolyze 10 parts of beta-casein (degree of hydrolysis DH is 50),
45 parts of human milk oligosaccharides (18 parts of sialic acid, 27 parts of 2'-Fucosyl lactose), 15 parts of lactose, 10 parts of beta glucan.
Embodiment 3
Present embodiments provide a kind of alimentation composition for preventing infantile eczema, by total weight be 100 parts by weight in terms of, the battalion
Feeding composition includes: 55 parts of alpha lactalbumin, 30 parts of beta-casein, 5 parts of human milk oligosaccharides (6 ' -1 part of sialyl lactoses, 2 '-rock algaes
4 parts of glycosyl lactose), 10 parts of isomerizing lactose.
Comparative example 1
This comparative example provides a kind of alimentation composition, by total weight be 100 parts by weight in terms of, which includes:
Hydrolyze 65 parts of alpha lactalbumin (degree of hydrolysis DH is 20), 35 parts of human milk oligosaccharides (25 parts of sialic acid, 3 '-fucosyllactoses 10
Part).
Comparative example 2
This comparative example provides a kind of alimentation composition, by total weight be 100 parts by weight in terms of, which includes:
Hydrolyze 40 parts of beta-casein (degree of hydrolysis DH is 8), 35 parts of human milk oligosaccharides (18 parts of sialic acid, 27 parts of 2'-Fucosyl lactose), cream
25 parts of sugar.
Comparative example 3
This comparative example provides a kind of alimentation composition for preventing infantile eczema, by total weight be 100 parts by weight in terms of, the battalion
Feeding composition include: hydrolysis 40 parts of alpha lactalbumin (degree of hydrolysis DH be 20), hydrolyze 25 parts of beta-casein (degree of hydrolysis DH is 15),
35 parts of lactose.
Zoopery:
Selection mouse 160, half male and half female will be randomly divided into 8 groups after mouse adaptive feeding 5d, Normal group, battalion
It supports and intervenes control group (comparative example 1), nutritional intervention control group 2 (comparative example 2), nutritional intervention control group 3 (comparative example 3), nutrition
Intervention group 1 (embodiment 1), nutritional intervention group 2 (embodiment 2), nutritional intervention group 3 (embodiment 3), every group 20.Nutritional intervention
Group presses the stomach-filling of 0.4mL/10g weight every time, and 2 times a day, continuous 15d, Normal group and model control group are under equal conditions
Distilled water stomach-filling；Carrying out stomach-filling to each group mouse gentamicin sulphate, Cefradine, (daily every dosage is respectively 30mg
And 40mg, it is made into after mixed solution by dosage and 0.3mL/ is administered only, daily stomach-filling 2 times, continuous 15 days.In back of mice electricity consumption
Dynamic shave depilation, detects the percutaneous loss of moist amount of back of mice skin using Multi-functional skin tester, cuticula contains respectively
Water.With the method anesthetized mice of intraperitoneal injection 9% chloraldurate (0.003ml/g) before detection, detection process is in closed chamber
Interior progress.
Statistical procedures are carried out using SPSS17.0 statistics software, gained measurement data is with average ± standard deviation (χ2
± S) it indicates, it is for statistical analysis using the methods of variance analysis, it is that difference is statistically significant with P < 0.05.As a result such as table 1
It is shown.
Table 1
| Group | Cuticula moisture content (Au) | Transepidermal water loss amount (g/m2h) |
| Normal group | 50.69±4.36 | 7.88±3.65 |
| Model control group | 38.28±5.33 | 12.54±5.87 |
| Nutritional intervention group 1 | 48.56±6.47② | 8.97±4.81② |
| Nutritional intervention group 2 | 45.56±3.31② | 8.66±6.22② |
| Nutritional intervention group 3 | 49.56±7.38② | 8.55±4.23② |
| Nutritional intervention control group 1 | 40.12±6.16① | 10.98±3.33① |
| Nutritional intervention control group 2 | 39.56±5.84① | 11.01±6.59① |
| Nutritional intervention control group 3 | 44.56±6.69① | 9.87±4.21① |
Note: " 1. " indicates that there were significant differences compared with Normal group；" 2. " indicate that there were significant differences compared with model group.
Experimental result:
The results show that compared with model control group, 1 back of mice keratoderma moisture content of nutritional intervention control group with
And transepidermal water loss amount is without significant changes (P>0.05), and then there were significant differences (P<0.05) with Normal group；And
Nutritional intervention group is just the opposite with it, i.e., with Normal group without significant difference (P > 0.05), and then has with model control group aobvious
It writes difference (P < 0.05).This result shows that, after being intervened using alimentation composition of the invention, the inflammation of body can be obvious
Weaken, alimentation composition has remarkable result to prevention body eczema.And each ingredient is not in range provided by the present invention
Composition will not play prevention effect to body eczema.Equally, embodiment 2, embodiment 3 have been also demonstrated that nutrition group of the invention
Closing object has the function of preventing eczema.
In order to probe into the function and effect of dietary fiber in the present composition, this experimental design nutritional intervention control group
(comparative example 3), the results showed that, when not adding dietary fiber in nutrient composition, alimentation composition can be weakened, eczema is prevented
And the effect for the treatment of.
In conclusion alimentation composition of the invention has effective prevention or therapeutic effect to eczema, mainly act as
Ingredient is dietary fiber, alpha lactalbumin, beta-casein and its hydrolysate, but in further probe process, is lacked
This effect of dietary fiber, alimentation composition can be weakened significantly, i.e., dietary fiber plays in the alimentation composition to wet
The facilitation of rash prevention or treatment.
Claims (11)
1. a kind of for preventing the alimentation composition of infantile eczema, in parts by weight, which includes: alpha lactalbumin
And/or 10-30 parts of 20-55 parts of its hydrolysate, beta-casein and/or its hydrolysate, human milk oligosaccharides and/or its precursor 0.2-
45 parts, 5-10 parts of dietary fiber.
2. alimentation composition according to claim 1, wherein the content of the beta-casein and/or its hydrolysate is
15-25 parts.
3. alimentation composition according to claim 1 or 2, wherein the alpha lactalbumin and/or its hydrolysate and β-
The mass ratio of casein and/or its hydrolysate is=1:2-3:1；Preferably 2:1.
4. requiring the described in any item alimentation compositions of 1-3 according to power, wherein the hydrolysis of the alpha lactalbumin and beta-casein
Spending DH is 8 or more, preferably 10-50, more preferably 20-40.
5. alimentation composition according to claim 1-4, wherein the human milk oligosaccharides and/or its precursor include:
One of acidic oligosaccharide, neutral oligosaccharides, N- acetyl glucosamine oligosaccharides and human milk oligosaccharides precursor or a variety of combinations, also,
Including at least a kind of neutral oligosaccharides；
Preferably, the human milk oligosaccharides and/or its precursor include acidic oligosaccharide and neutral oligosaccharides, also, the mass ratio 1 of the two:
4-1:2。
6. alimentation composition according to claim 5, wherein the acidic oligosaccharide includes sialic acid and/or sulfate knot
The oligosaccharide of structure preferably includes sialylated-sialylated lactose of lacto-N-tetraose c, 6'-, the sialylated lactose of 3'-, saliva
One or more of acidification-lacto-N-tetraose a, sialylated-lacto-N-tetraose b, two sialic acids-lacto-N-tetraose
Combination；
The neutral oligosaccharides include the oligosaccharide of no fucosido and/or the oligosaccharide containing fucosido, preferably include 2'- rock algae
Glycosyl lactose, 3'- fucosyllactose, 2', 3- fucosyllactose, the new tetrose of lactoyl-N-, lacto-N-fucopentaose -1, cream
The combination of one or more of acyl-N- rock algae pentasaccharides -2, lacto-N-fucopentaose -3, two rock algae of lactoyl-N-, six sugar -1.
7. alimentation composition according to claim 1-6, wherein the human milk oligosaccharides and/or its precursor include
Sialic acid, 3 '-sialyl lactoses, 6 '-sialyl lactoses, 2'-Fucosyl lactose, 3 '-fucosyllactoses, lactose-N- are new
The combination of one or more of tetrose and two sialyl lactose-N- tetroses.
8. alimentation composition according to claim 1-7, wherein the dietary fiber includes oligofructose, β-
One of glucan, polydextrose and isomerizing lactose or a variety of combinations.
9. alimentation composition according to claim 1-8, wherein the total weight of the alimentation composition is 100 weights
Part is measured, with the combination polishing of one or more of fat, carbohydrate, minerals, vitamin and water.
10. the described in any item alimentation compositions of claim 1-9 are in the composition that preparation has prevention infantile eczema effect
Application.
11. a kind of children's food, it is described in any item for preventing the nutrient combination of infantile eczema that it includes claim 1-9
Object；Preferably, which is children's formula milk.
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| CN201811056697.9A CN108935697A (en) | 2018-09-11 | 2018-09-11 | It is a kind of for preventing the alimentation composition of infantile eczema |
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| CN114555784A (en) * | 2019-10-08 | 2022-05-27 | 金科生物科技股份公司 | Composition for enhancing dryness and use thereof |
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