CN108929251B - Method for direct trifluoromethylation of C (sp3) -H - Google Patents

Method for direct trifluoromethylation of C (sp3) -H Download PDF

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CN108929251B
CN108929251B CN201810725302.3A CN201810725302A CN108929251B CN 108929251 B CN108929251 B CN 108929251B CN 201810725302 A CN201810725302 A CN 201810725302A CN 108929251 B CN108929251 B CN 108929251B
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trifluoromethylthio
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CN108929251A (en
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杭晓春
赵越
张宏海
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Nanjing Tech University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/18—Systems containing only non-condensed rings with a ring being at least seven-membered
    • C07C2601/20—Systems containing only non-condensed rings with a ring being at least seven-membered the ring being twelve-membered

Abstract

The invention discloses a method for directly trifluoromethylylating C (sp3) -H. The method takes alkane as raw material, silver carbonate as catalyst, potassium persulfate as oxidant and trifluoro sulfinyl chloride and triphenylphosphine as trifluoromethylthio reagent, and synthesizes target compound in nitrile solvent at 30-80 ℃. The method has mild reaction conditions, good functional group tolerance and good selectivity, avoids using expensive trifluoromethylthio silver as a trifluoromethylthio reagent in the reaction process, reduces the production cost, and is suitable for large-scale production. The yield of the direct trifluoromethylthio of C (sp3) -H is more than medium, and the physical, chemical and biological properties of the compound can be significantly influenced due to the strong electronegativity and high lipophilicity. Can be applied to the fields of medicines, agricultural chemicals, materials and the like.

Description

Method for direct trifluoromethylation of C (sp3) -H
Technical Field
The invention belongs to the field of organic synthesis, and particularly relates to a method for directly trifluoromethylthiolating SP3 carbon hydrogen bonds on alkane.
Background
Trifluoromethylthio (SCF)3) As a very important one of the fluorine-containing functional groups, the Hansch constant of the fluorine-containing functional group is as high as 1.44, and the fluorine-containing functional group is one of the most lipophilic functional groups. The introduction of the compound into drug molecules can increase the cell permeability of the drug molecules, thereby effectively improving the cell metabolic activity and the biological activity of the drug molecules. At the same time, SCF3The electronegativity is larger, and the electron cloud density of a system can be reduced by introducing the group into the molecule, so that the oxidation resistance of the molecule is obviously improved, and the metabolic stability of the compound is increased. The trifluoromethylthio group-containing molecule has high lipid solubility and strong electron-withdrawing capability, can change the molecular pharmacokinetics and physicochemical characteristics and improve the metabolic stability by introducing the trifluoromethylthio group into a drug molecule, and is widely applied to the fields of medicines, pesticides, materials, fluorine-containing daily necessities and the like.
The fluorine-containing organic compound is used in medicine and agricultural chemistryThe increasing importance of articles and materials, etc., has prompted the development of new methods for introducing fluorine into small molecules. Due to trifluoromethylthio (SCF)3) Are highly electroattractive and highly lipophilic, which has attracted much attention for the introduction of new pharmaceuticals and agrochemicals. Therefore, the development of a new trifluoromethyl sulfurization process is very interesting for the synthesis of organic chemicals. However, selective trifluoromethylthio of the inert C (sp3) -H bond remains a significant challenge. The selective trifluoromethylthio of the inert C (sp3) -H bond reported to date has the disadvantage that, firstly, the use of the expensive silver trifluoromethylthio (Angew. chem. int. Ed.2015,54, 4065-; secondly, the substrate selectivity is poor (Angew. chem. int. Ed.2015,54, 4070-; thirdly, expensive photocatalyst is used, the system is complex, and the method is not suitable for industrialization (J.Am.chem.Soc.2016,138, 16200-16203). In order to solve the problems, the applicant invents a method for preparing C (sp3) -H direct trifluoromethylthio, the method has mild reaction conditions, good functional group tolerance and good selectivity, expensive trifluoromethylthio silver is avoided being used as a trifluoromethylthio reagent in the reaction process, the production cost is reduced, and the method is suitable for large-scale production. The yield of the direct trifluoromethylthio of C (sp3) -H is more than medium, and the physical, chemical and biological properties of the compound can be significantly influenced due to the strong electronegativity and high lipophilicity. Can be applied to the fields of medicines, agricultural chemicals, materials and the like.
Disclosure of Invention
The technical problem to be solved by the invention is as follows: aiming at the defect of selective trifluoromethylthio of an inert C (sp3) -H bond in the prior art, the method provides a method for synthesizing a target compound by using alkane as a starting material and carrying out C-H activation reaction catalyzed by silver carbonate and oxidized by potassium persulfate. Provides a high-efficiency synthesis method for the synthesis of various C (SP3) -H (SP3 carbon hydrogen bond on alkane) direct trifluoromethylthio.
In order to solve the technical problem, the invention provides a method for directly trifluoromethylthio of C (sp3) -H, which takes alkane as a raw material, silver carbonate as a catalyst, potassium persulfate as an oxidant, trifluorosulfinyl chloride as a trifluoromethylthio reagent, triphenylphosphine for reducing the trifluorosulfinyl chloride, and the reaction is carried out in a nitrile solvent at 30-80 ℃ for more than 3 hours to synthesize a target compound, wherein the synthesis reaction formula of the target compound is as follows:
Figure BDA0001719567360000021
wherein Alkyl represents all Alkyl groups.
Preferably, the nitrile solvent is acetonitrile.
Preferably, the reaction temperature is 60 ℃ and the reaction time is 12 hours.
Preferably, the whole reaction process for synthesizing the target compound in the method is completed under a nitrogen protection system.
Wherein the alkane used as the raw material has a structural formula shown as the following 1a-1 o:
Figure BDA0001719567360000022
the compound 2a-2o prepared by the method for directly trifluoromethylating C (sp3) -H has the following structural formula:
Figure BDA0001719567360000031
preferably, the molar ratio of the raw materials fed is CF3SOCl: alkane: PPh 3-1: 1.5: 1.5.
Preferably, the catalyst is used in an amount of 1 equivalent of the alkane and the oxidant is used in an amount of 1.5 equivalents of the alkane.
The invention has the beneficial effects that: the invention relates to a direct trifluoromethylthio reaction of C (sp3) -H in which a trifluoromethylthio radical participates. The method has the advantages of mild reaction conditions, good functional group tolerance and good selectivity, avoids using expensive trifluoromethylthio silver as a trifluoromethylthio reagent in the reaction process, reduces the production cost, and is suitable for large-scale production. The yield of the direct trifluoromethylthio of the C (sp3) -H is more than moderate. Since it has strong electronegativity and high lipophilicity, it can significantly affect the physical, chemical and biological properties of a compound. Can be applied to the fields of medicines, agricultural chemicals, materials and the like.
Detailed Description
The invention is further illustrated by the following examples.
Example 1
To a 15mL stoppered tube were added sequentially trifluorosulfinyl chloride (61mg, 0.4mmol), cyclooctane (59mg, 0.6mmol), triphenylphosphine (157mg, 0.6mmol), silver carbonate (110mg, 0.4mmol), potassium persulfate (162mg, 0.6mmol), and acetonitrile (3 mL). And (3) replacing with high-purity nitrogen for three times, reacting at 60 ℃ for 12 hours, filtering by using kieselguhr, washing by using dichloromethane, combining organic phases, concentrating an organic solvent, and further purifying a product by using column chromatography to obtain the compound 2a with the F spectrum yield of 80%.1H NMR(400MHz,CDCl3)δ3.49(tt,J＝8.8,4.1Hz,1H),2.11–2.04(m,2H),1.83–1.69(m,4H),1.63–1.49(m,8H).13C NMR(101MHz,CDCl3)δ131.7(q,J＝306.1Hz),45.9,32.9,27.5,25.9,25.0.19F NMR(376MHz,CDCl3)δ-39.70(s,3F)
Example 2
To a 15mL block was added sequentially trifluorosulfinyl chloride (61mg, 0.4mmol), cycloheptane (67mg, 0.6mmol), triphenylphosphine (157mg, 0.6mmol), silver carbonate (110mg, 0.4mmol), potassium persulfate (162mg, 0.6mmol) and acetonitrile (3 mL). And (3) replacing with high-purity nitrogen for three times, reacting at 60 ℃ for 12 hours, filtering by using kieselguhr, washing by using dichloromethane, combining organic phases, concentrating an organic solvent, and further purifying a product by using column chromatography to obtain a compound 2b, wherein the F spectrum yield is 59%.1H NMR(400MHz,CDCl3)δ3.46(tt,J＝8.9,4.4Hz,1H),2.09(dt,J＝13.6,6.9Hz,2H),1.71(td,J＝16.1,15.5,8.6Hz,4H),1.63–1.48(m,6H).13C NMR(101MHz,CDCl3)δ131.6(q,J＝306.2Hz),46.3,35.8,28.4,25.7.19F NMR(376MHz,CDCl3)δ-39.68(s,3F)
Example 3
To a 15mL stoppered tube were added sequentially trifluorosulfinyl chloride (61mg, 0.4mmol), cyclodecane (84mg, 0.6mmol), triphenylphosphine (157mg, 0.6mmol), silver carbonate (110 m)g, 0.4mmol), potassium persulfate (162mg, 0.6mmol) and acetonitrile (3 mL). And (3) replacing the mixture with high-purity nitrogen for three times, reacting at 60 ℃ for 12 hours, filtering the mixture with diatomite, washing the mixture with dichloromethane, combining organic phases, concentrating an organic solvent, and further purifying a product by column chromatography to obtain a compound 2c with the F spectrum yield of 61%.1H NMR(400MHz,CDCl3)δ3.63–3.50(m,1H),1.88(dddd,J＝27.0,20.8,14.7,6.5Hz,4H),1.63(dd,J＝11.5,5.6Hz,4H),1.54(q,J＝9.6,7.0Hz,10H).13C NMR(101MHz,CDCl3)δ131.7(d,J＝306.1Hz),44.0,32.2,25.6,25.1,24.9,23.7.19F NMR(376MHz,CDCl3)δ-39.61(s,3F).
Example 4
To a 15mL block was added sequentially trifluorosulfinyl chloride (61mg, 0.4mmol), cyclododecane (101mg, 0.6mmol), triphenylphosphine (157mg, 0.6mmol), silver carbonate (110mg, 0.4mmol), potassium persulfate (162mg, 0.6mmol) and acetonitrile (3 mL). And (3) replacing the mixture with high-purity nitrogen for three times, reacting at 60 ℃ for 12 hours, filtering the mixture with diatomite, washing the mixture with dichloromethane, combining organic phases, concentrating an organic solvent, and further purifying a product by column chromatography to obtain a compound 2d with the F spectrum yield of 61%.1HNMR(400MHz,CDCl3)δ3.32(ddd,J＝12.8,7.5,5.3Hz,1H),1.81(dq,J＝13.9,6.7Hz,2H),1.65(dq,J＝12.5,5.8Hz,2H),1.53(dt,J＝13.4,7.1Hz,2H),1.42–1.31(m,16H).13C NMR(101MHz,CDCl3)δ131.8(d,J＝306.1Hz),42.9,31.3,24.2,24.0,23.8,23.7,22.3.19F NMR(376MHz,CDCl3)δ-39.59(s,3F)
Example 5
To a 15mL block was added sequentially trifluorosulfinyl chloride (61mg, 0.4mmol), 5-methyl-2-hexanone (68mg, 0.6mmol), triphenylphosphine (157mg, 0.6mmol), silver carbonate (110mg, 0.4mmol), potassium persulfate (162mg, 0.6mmol) and acetonitrile (3 mL). And (3) replacing with high-purity nitrogen for three times, reacting at 60 ℃ for 12 hours, filtering by using kieselguhr, washing by using dichloromethane, combining organic phases, concentrating an organic solvent, and further purifying a product by using column chromatography to obtain a compound 2e, wherein the F spectrum yield is 83%.1HNMR(400MHz,CDCl3)δ2.66–2.54(m,2H),2.15(s,3H),1.98–1.87(m,2H),1.41(s,6H).13CNMR(101MHz,CDCl3)δ207.6,138.6–122.5(m),51.7,39.4,36.4,30.2,29.7.19F NMR(376MHz,CDCl3)δ-35.97(s,3F).
Example 6
To a 15mL block was added sequentially trifluorosulfinyl chloride (61mg, 0.4mmol), 4-methyl-2-pentanone (60mg, 0.6mmol), triphenylphosphine (157mg, 0.6mmol), silver carbonate (110mg, 0.4mmol), potassium persulfate (162mg, 0.6mmol), and acetonitrile (3 mL). And (3) replacing with high-purity nitrogen for three times, reacting at 60 ℃ for 12 hours, filtering by using kieselguhr, washing by using dichloromethane, combining organic phases, concentrating an organic solvent, and further purifying a product by using column chromatography to obtain a compound 2F, wherein the F spectrum yield is 44%.1HNMR(400MHz,CDCl3)δ2.90(s,2H),2.16(s,3H),1.58(s,6H).13C NMR(101MHz,CDCl3)δ205.5,131.2(q,J＝307.7Hz),54.8,49.4,32.1,29.2.19F NMR(376MHz,CDCl3)δ-35.68(s,3F).
Example 7
To a 15mL block tube was added sequentially trifluorosulfinyl chloride (61mg, 0.4mmol), valeronitrile (50mg, 0.6mmol), triphenylphosphine (157mg, 0.6mmol), silver carbonate (110mg, 0.4mmol), potassium persulfate (162mg, 0.6mmol), and acetonitrile (3 mL). And (3) replacing the mixture with high-purity nitrogen for three times, reacting at 60 ℃ for 12 hours, filtering the mixture with diatomite, washing the filtered mixture with dichloromethane, combining organic phases, concentrating an organic solvent, and further purifying the product by column chromatography to obtain 2g of a compound, wherein the F spectrum yield is 45%.1H NMR(400MHz,CDCl3)δ3.38(h,J＝7.0Hz,1H),2.54(t,J＝7.3Hz,2H),1.99(dp,J＝22.3,7.1Hz,2H),1.49(d,J＝7.0Hz,3H).13C NMR(101MHz,CDCl3)δ136.9–124.6(m),118.8,40.2,32.7,22.4,15.1.19F NMR(376MHz,CDCl3)δ-38.94(s,3F).
Example 8
To a 15mL block was added sequentially trifluorosulfinyl chloride (61mg, 0.4mmol), 1-bromo-3-methylbutane (91mg, 0.6mmol), triphenylphosphine (157mg, 0.6mmol), silver carbonate (110mg, 0.4mmol), potassium persulfate (162mg, 0.6mmol), and acetonitrile (3 mL). Replacing with high-purity nitrogen for three times, reacting at 60 deg.C for 12 hr, filtering with diatomaceous earth, washing with dichloromethane, mixing organic phases, concentrating organic solvent, purifying by column chromatography to obtain compound 2h, and performing F spectral analysisThe rate was 56%.1HNMR(400MHz,CDCl3)δ3.54–3.43(m,2H),2.32–2.22(m,2H),1.48(s,6H).13C NMR(101MHz,CDCl3)δ130.9(q,J＝307.9Hz),52.0,46.4,29.7,27.5.19F NMR(376MHz,CDCl3)δ-35.95(s,3F).
Example 9
To a 15mL block tube was added sequentially trifluorosulfinyl chloride (61mg, 0.4mmol), isobutyl acetate (70mg, 0.6mmol), triphenylphosphine (157mg, 0.6mmol), silver carbonate (110mg, 0.4mmol), potassium persulfate (162mg, 0.6mmol) and acetonitrile (3 mL). And (3) replacing with high-purity nitrogen for three times, reacting at 60 ℃ for 12 hours, filtering by using kieselguhr, washing by using dichloromethane, combining organic phases, concentrating an organic solvent, and further purifying a product by using column chromatography to obtain a compound 2i, wherein the F spectrum yield is 63%.1HNMR(400MHz,CDCl3)δ4.14(s,2H),2.10(s,3H),1.46(s,6H).13C NMR(101MHz,CDCl3)δ170.8,138.6–123.7(m),71.1,50.1,26.5,21.0.19F NMR(376MHz,CDCl3)δ-35.45(s,3F)
Example 10
To a 15mL block was added sequentially trifluorosulfinyl chloride (61mg, 0.4mmol), ethyl isovalerate (78mg, 0.6mmol), triphenylphosphine (157mg, 0.6mmol), silver carbonate (110mg, 0.4mmol), potassium persulfate (162mg, 0.6mmol), and acetonitrile (3 mL). And (3) replacing with high-purity nitrogen for three times, reacting at 60 ℃ for 12 hours, filtering by using kieselguhr, washing by using dichloromethane, combining organic phases, concentrating an organic solvent, and further purifying a product by using column chromatography to obtain the compound 2j, wherein the F spectral yield is 71%.1HNMR(400MHz,CDCl3)δ4.15(q,J＝7.1Hz,2H),2.75(s,2H),1.59(s,6H),1.26(t,J＝7.1Hz,3H).13C NMR(101MHz,CDCl3)δ169.9,131.1(q,J＝307.9Hz),61.0,49.2,47.8,29.4,14.5.19F NMR(376MHz,CDCl3)δ-35.91(s,3F).
Example 11
To a 15mL block was added sequentially trifluorosulfinyl chloride (61mg, 0.4mmol), methyl 4-methylpentanoate (78mg, 0.6mmol), triphenylphosphine (157mg, 0.6mmol), silver carbonate (110mg, 0.4mmol), potassium persulfate (162mg, 0.6mmol) and acetonitrile (3 mL). High-purity nitrogen is replaced for three times, and the reaction is carried out for 12 hours at 60 DEG CAfter time, celite was filtered, washed with dichloromethane, the organic phases were combined, the organic solvent was concentrated, and the product was further purified by column chromatography to give compound 2k with 75% F spectral yield.1HNMR(400MHz,CDCl3)δ3.66(s,3H),2.53–2.41(m,2H),2.07–1.96(m,2H),1.43(s,6H).13CNMR(101MHz,CDCl3)δ173.7,131.1(q,J＝307.6Hz),52.1,51.5,37.9,30.1,29.5.19F NMR(376MHz,CDCl3)δ-35.97(s,3F)..
Example 12
To a 15mL block tube was added sequentially trifluorosulfinyl chloride (61mg, 0.4mmol), 4-isopropylcyclohexanone (84mg, 0.6mmol), triphenylphosphine (157mg, 0.6mmol), silver carbonate (110mg, 0.4mmol), potassium persulfate (162mg, 0.6mmol) and acetonitrile (3 mL). And (3) replacing with high-purity nitrogen for three times, reacting at 60 ℃ for 12 hours, filtering by using kieselguhr, washing by using dichloromethane, combining organic phases, concentrating an organic solvent, and further purifying a product by using column chromatography to obtain the compound 2l, wherein the F spectrum yield is 75%.1HNMR(400MHz,CDCl3)δ2.45–2.21(m,6H),2.02(t,J＝12.0Hz,1H),1.55(td,J＝13.6,12.4,5.4Hz,2H),1.46(s,6H).13C NMR(101MHz,CDCl3)δ210.9,138.1–124.4(m),55.5,46.4,40.9,27.7,27.2.19F NMR(376MHz,CDCl3)δ-35.01(s,3F)..
Example 13
To a 15mL block tube was added sequentially trifluorosulfinyl chloride (61mg, 0.4mmol), isoamyl benzoate (288mg, 0.6mmol), triphenylphosphine (157mg, 0.6mmol), silver carbonate (110mg, 0.4mmol), potassium persulfate (162mg, 0.6mmol) and acetonitrile (3 mL). And (3) replacing with high-purity nitrogen for three times, reacting at 60 ℃ for 12 hours, filtering by using kieselguhr, washing by using dichloromethane, combining organic phases, concentrating an organic solvent, and further purifying a product by using column chromatography to obtain a compound 2m, wherein the F spectrum yield is 83%.1HNMR(400MHz,CDCl3)δ8.03(d,J＝8.5Hz,2H),7.56(t,J＝7.4Hz,1H),7.44(t,J＝7.7Hz,2H),4.52(t,J＝6.7Hz,2H),2.21(t,J＝6.7Hz,2H),1.56(s,6H).13C NMR(101MHz,CDCl3)δ166.7,133.4,131.1(q,J＝307.6Hz),130.4,129.9,128.7,61.9,50.6,41.6,30.1.19F NMR(376MHz,CDCl3)δ-35.76(s,3F).
Example 14
To a 15mL block tube were added sequentially trifluorosulfinyl chloride (61mg, 0.4mmol), N-isopentyloxyphthalimide (140mg, 0.6mmol), triphenylphosphine (157mg, 0.6mmol), silver carbonate (110mg, 0.4mmol), potassium persulfate (162mg, 0.6mmol) and acetonitrile (3 mL). Replacing with high-purity nitrogen for three times, reacting at 60 ℃ for 12 hours, filtering with diatomite, washing with dichloromethane, combining organic phases, concentrating an organic solvent, further purifying a product by column chromatography to obtain a compound 2n, wherein the F spectrum yield is 54%.1H NMR(400MHz,CDCl3)δ7.81(dd,J＝5.5,3.1Hz,2H),7.74(dd,J＝5.4,3.1Hz,2H),4.38(t,J＝6.4Hz,2H),2.22(t,J＝6.4Hz,2H),1.56(s,6H).13C NMR(101MHz,CDCl3)δ163.7,134.9,131.0(q,J＝307.6Hz),129.2,123.9,75.5,50.8,40.9,30.0.19F NMR(376MHz,CDCl3)δ-35.89(s,3F)..
Example 15
To a 15mL block was added sequentially trifluorosulfinyl chloride (61mg, 0.4mmol), N-isopentylphthalimide (130mg, 0.6mmol), triphenylphosphine (157mg, 0.6mmol), silver carbonate (110mg, 0.4mmol), potassium persulfate (162mg, 0.6mmol), and acetonitrile (3 mL). And (3) replacing with high-purity nitrogen for three times, reacting at 60 ℃ for 12 hours, filtering by using kieselguhr, washing by using dichloromethane, combining organic phases, concentrating an organic solvent, and further purifying a product by using column chromatography to obtain the compound 2o, wherein the F spectral yield is 81%.1HNMR(400MHz,CDCl3)δ7.81(dd,J＝5.1,3.0Hz,2H),7.69(dd,J＝5.2,3.0Hz,2H),3.90–3.65(m,2H),2.12–1.97(m,2H),1.52(s,6H).13C NMR(101MHz,CDCl3)δ168.3,134.3,132.4,131.0(q,J＝307.9Hz),123.5,50.4,41.1,34.5,29.6.19F NMR(376MHz,CDCl3)δ-35.76(s,3F)..
The foregoing shows and describes the general principles, essential features, and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.

Claims (6)

1. A method for directly trifluoromethylating C (sp3) -H is characterized in that alkane is used as raw material, silver carbonate is used as catalyst, potassium persulfate is used as oxidant, trifluorosulfinyl chloride and triphenylphosphine are used as trifluoromethylating reagent, and the reaction temperature is 30-80 ℃ in nitrile solvent, the reaction is carried out for more than 3 hours, and the target compound is synthesized, wherein the synthesis reaction formula of the target compound is as follows:
Figure FDA0002325391530000011
wherein Alkyl represents all Alkyl groups and the ratio is the molar ratio of the substances.
2. A process for the direct trifluoromethylthiolation of C (sp3) -H according to claim 1, wherein the nitrile solvent is acetonitrile.
3. The process for the direct trifluoromethylation of C (sp3) -H according to claim 1, wherein the reaction temperature is 60 ℃ and the reaction time is 12 hours.
4. The method for direct trifluoromethylation of C (sp3) -H according to claim 1, wherein the whole reaction process for synthesizing the objective compound is performed under a nitrogen protection system.
5. A method for directly trifluoromethylating C (sp3) -H is characterized in that alkane is used as raw material, silver carbonate is used as catalyst, potassium persulfate is used as oxidant, trifluorosulfinic acid chlorine and triphenylphosphine are used as trifluoromethylating reagent, and the reaction temperature is 30-80 ℃ in nitrile solvent, the reaction is carried out for more than 3 hours, and the target compound is synthesized, wherein the synthesis reaction formula of the target compound is as follows:
Figure FDA0002325391530000012
wherein the ratio is a molar ratio of each substance, and the alkane used as the raw material has a structural formula shown as the following 1a-1 o:
Figure FDA0002325391530000021
6. the process for the direct trifluoromethylthiolation of C (sp3) -H according to claim 5, wherein the alkane 1a-1o is used as a starting material, and wherein the compound obtained has the following structural formula:
Figure FDA0002325391530000031
CN201810725302.3A 2018-07-04 2018-07-04 Method for direct trifluoromethylation of C (sp3) -H Active CN108929251B (en)

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