CN108926705A - A kind of pharmaceutical composition and the preparation method and application thereof for treating rheumatic spur strain - Google Patents

A kind of pharmaceutical composition and the preparation method and application thereof for treating rheumatic spur strain Download PDF

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Publication number
CN108926705A
CN108926705A CN201811177345.9A CN201811177345A CN108926705A CN 108926705 A CN108926705 A CN 108926705A CN 201811177345 A CN201811177345 A CN 201811177345A CN 108926705 A CN108926705 A CN 108926705A
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weight
parts
radix
strain
treatment
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王海平
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China Merchants State Incubator Group Ltd
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China Merchants State Incubator Group Ltd
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/58—Reptiles
    • A61K35/586—Turtles; Tortoises, e.g. terrapins
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    • A61K36/02—Algae
    • A61K36/03—Phaeophycota or phaeophyta (brown algae), e.g. Fucus
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Abstract

The pharmaceutical composition for the treatment of rheumatic spur strain of the present invention, with tripterygium wilfordii, Ramulus euonymi, thallus laminariae, Prunella vulgaris, vinegar turtle shell, tortoiseshell, Poria cocos, rhizoma alismatis, the root of fangji, bush, Radix Salviae Miltiorrhizae, peach kernel, safflower, Radix Angelicae Sinensis, Fructus meliae toosendan, radix cyathulae, the root of Chinese clematis, ramulus cinnamomi, Radix Angelicae Pubescentis, berba aristolochiae mollissimae, turpentine, pericarpium zanthoxyli, gentianae macrophyllae, capsicum, lycopodium calvatum, lopseed, monkshood, radix aconiti agrestis, caulis trachelospermi, caulis piperis futokadsurae, rhizoma dioscoreae nipponicae, Rhizoma Chuanxiong, radix saposhnikoviae, olibanum, myrrh, member is acted like a bully traditional Chinese medicinal components, and with centipede, scorpio, toad-cortex, Eupolyphoge sinensis, agkistrodon, honeybee, earthworm, gecko, leech is that raw material extracts insect protein, to edema caused by wind-dampness, spur strain has preferable therapeutic effect, has effects that certain kidney tonifying simultaneously.And the pharmaceutical preparation for the treatment of rheumatic spur strain of the present invention, there is preferable therapeutic effect for each course of disease rheumatic spur disease, and safety is without any side effects.

Description

A kind of pharmaceutical composition and the preparation method and application thereof for treating rheumatic spur strain
Technical field
The invention belongs to technical field of medicine, and in particular to a kind of kidney-reinforcing drug for treating edema caused by wind-dampness and spur strain Compositions, and preparation method and application are further disclosed.
Background technique
The bone and joint diseases such as edema caused by wind-dampness, lumbar muscle strain, osteoproliferation are chronic diseases common now, are especially mainly in The middle-aged and the old and the person that needs sedentary occupation, usually bring many pains to patient, are the difficult chronic diseases of field of orthopaedics.It mainly faces It is limited that bed shows as swollen joint acid, numb, pain, limb function, controls or delay treatment if losing, and can gradate as chronic disease, Less serious case causes disorder of limb's activity, and severe one causes to paralyse, and seriously affects people's lives, and causes to the physical and mental health of people very big Pain, serious person even can threat to life.
Currently, treating above-mentioned illness mostly without good method or drug, existing treatment method mainly traction, needle The physical therapies such as toast, physical therapy, massage, massage, though muscles and bones can be loosened, pain of releiving cannot be eradicated, often touching refractory. Treatment of the current the world of medicine to above-mentioned bone and joint diseases, clinically commonly uses Western medicine and Chinese patent drug, such as antimicrobial, central excitation Medicine, antalgesic, antipyretic analgesic, that is, gout suppressant etc., but Long-term taking medicine especially largely take antibiotic, analgesic-antipyretic for a long time And gout suppressant, injury can be brought to the health of patient.In addition, existing usually used drug, such as " Musk Analgesic Plaster ", The drugs such as " SUANTONG LING ", " spur liquid ", " pain-relieving liquid ", " kanggu zengsheng pills " are and the mouths to eliminate pain as main target Object take medicine mostly through circulatory system liver detoxification, then is transported to lesion portion, effective ingredient remains little, the usual effective course for the treatment of compared with It is long and only effective to mild.Separately there is the heavier orthopaedics patients with chronic diseases of some illnesss that can operate on treatment using operation, not only wants Expensive medical expense is paid, and is easy to produce certain postoperative side effect, such problem is not possible to solve at present Certainly.
As it can be seen that developing a kind of drug that can effectively treat edema caused by wind-dampness and spur strain, there is positive meaning.
Summary of the invention
For this purpose, technical problem to be solved by the present invention lies in provide a kind of kidney tonifying for treating edema caused by wind-dampness and spur strain Pharmaceutical composition, and preparation method is further disclosed.
In order to solve the above technical problems, a kind of pharmaceutical composition for treating rheumatic spur strain of the present invention, described The bulk pharmaceutical chemicals composition of pharmaceutical composition includes: tripterygium wilfordii 12-18 parts by weight, Ramulus euonymi 12-18 parts by weight, thallus laminariae 10-15 weight Part, Prunella vulgaris 15-25 parts by weight, vinegar turtle shell 10-15 parts by weight, tortoiseshell 10-15 parts by weight, Poria cocos 12-18 parts by weight, rhizoma alismatis 10-15 parts by weight, root of fangji 15-25 parts by weight, bush 10-15 parts by weight, Radix Salviae Miltiorrhizae 15-25 parts by weight, peach kernel 15-25 parts by weight, Safflower 15-25 parts by weight, Radix Angelicae Sinensis 15-20 parts by weight, Fructus meliae toosendan 12-20 parts by weight, radix cyathulae 10-15 parts by weight, root of Chinese clematis 12- 20 parts by weight, ramulus cinnamomi 5-15 parts by weight, Radix Angelicae Pubescentis 10-15 parts by weight, berba aristolochiae mollissimae 15-20 parts by weight, turpentine 10-15 parts by weight, river Green pepper 15-25 parts by weight, gentianae macrophyllae 15-25 parts by weight, capsicum 15-25 parts by weight, lycopodium calvatum 15-25 parts by weight, lopseed 15-25 weight Measure part, monkshood 10-15 parts by weight, radix aconiti agrestis 10-15 parts by weight, caulis trachelospermi 12-18 parts by weight, caulis piperis futokadsurae 10-15 parts by weight, Chuan Shan Imperial 10-15 parts by weight, Rhizoma Chuanxiong 12-20 parts by weight, radix saposhnikoviae 10-15 parts by weight, olibanum 15-25 parts by weight, myrrh 15-25 weight Part, corydalis tuber 25-35 parts by weight, insect protein 0.035-0.04 parts by weight.
Preferably, the bulk pharmaceutical chemicals composition of the pharmaceutical composition for the treatment of rheumatic spur strain includes: 15 weight of tripterygium wilfordii Measure part, 15 parts by weight of Ramulus euonymi, 12 parts by weight of thallus laminariae, 20 parts by weight of Prunella vulgaris, 12 parts by weight of vinegar turtle shell, 12 parts by weight of tortoiseshell, 15 parts by weight of Poria cocos, 12 parts by weight of rhizoma alismatis, 20 parts by weight of the root of fangji, 12 parts by weight of bush, 20 parts by weight of Radix Salviae Miltiorrhizae, 20 weight of peach kernel Part, 20 parts by weight of safflower, 18 parts by weight of Radix Angelicae Sinensis, 16 parts by weight of Fructus meliae toosendan, 12 parts by weight of radix cyathulae, 16 parts by weight of the root of Chinese clematis, osmanthus Branch 10 parts by weight, 12 parts by weight of Radix Angelicae Pubescentis, 18 parts by weight of berba aristolochiae mollissimae, 12 parts by weight of turpentine, 20 parts by weight of pericarpium zanthoxyli, 20 weight of gentianae macrophyllae Part, 20 parts by weight of capsicum, 20 parts by weight of lycopodium calvatum, 20 parts by weight of lopseed, 12 parts by weight of monkshood, 12 parts by weight of radix aconiti agrestis, trachelospermum jasminoide 15 parts by weight of rattan, 12 parts by weight of caulis piperis futokadsurae, 12 parts by weight of rhizoma dioscoreae nipponicae, 16 parts by weight of Rhizoma Chuanxiong, windproof 12 parts by weight, 20 weight of olibanum Part, 20 parts by weight of myrrh, 30 parts by weight of corydalis tuber, 0.038 parts by weight of insect protein.
Specifically, the insect protein is with centipede, scorpio, toad-cortex, Eupolyphoge sinensis, agkistrodon, honeybee, earthworm, gecko, leech Water is carried out for raw material to obtain through refining.
Preferably, the centipede, scorpio, toad-cortex, Eupolyphoge sinensis, agkistrodon, honeybee, earthworm, gecko, leech mass ratio be 1: 2:0.4:1:1:0.5:1:0.8:2.
The invention also discloses the purposes that the pharmaceutical composition is used to prepare treatment rheumatic spur strain pharmaceutical preparation.
The invention also discloses by the pharmaceutical composition, customary adjuvant is added, according to clinic made from common process The external preparation of upper acceptable treatment rheumatic spur strain.
Specifically, the external preparation includes paste, patch, liniment or paint.
The invention also discloses a kind of methods of external preparation for preparing the treatment rheumatic spur strain, including walk as follows It is rapid:
(1) it takes a selected amount of tripterygium wilfordii, Ramulus euonymi, thallus laminariae, Prunella vulgaris, vinegar turtle shell, tortoiseshell, Poria cocos, rhizoma alismatis, prevent Oneself, bush, Radix Salviae Miltiorrhizae, peach kernel, safflower, Radix Angelicae Sinensis, Fructus meliae toosendan, radix cyathulae, the root of Chinese clematis, ramulus cinnamomi, Radix Angelicae Pubescentis, berba aristolochiae mollissimae, turpentine, pericarpium zanthoxyli, Gentianae macrophyllae, capsicum, lycopodium calvatum, lopseed, monkshood, radix aconiti agrestis, caulis trachelospermi, caulis piperis futokadsurae, rhizoma dioscoreae nipponicae, Rhizoma Chuanxiong, radix saposhnikoviae, olibanum, myrrh, member Recklessly, it crushes, sieves for subsequent use after mixing or mix after crushing；
(2) centipede, scorpio, toad-cortex, Eupolyphoge sinensis, agkistrodon, honeybee, earthworm, gecko, water are taken according to selected mass ratio Leech is raw material, and water is added to extract, and after collecting filtrate and being freeze-dried, insect protein freeze-dried powder is made, spare；
(3) gained traditional Chinese medicine powder in step (1) and a selected amount of insect protein freeze-dried powder are mixed, is added conventional auxiliary Material, is made clinically acceptable external preparation according to common process.
In the step (1), the sifting step was 200 meshes.
The auxiliary material includes potassium sorbate and/or red chili oil.
The pharmaceutical composition for the treatment of rheumatic spur strain of the present invention, with tripterygium wilfordii, Ramulus euonymi, thallus laminariae, Prunella vulgaris, vinegar Turtle shell, tortoiseshell, Poria cocos, rhizoma alismatis, the root of fangji, bush, Radix Salviae Miltiorrhizae, peach kernel, safflower, Radix Angelicae Sinensis, Fructus meliae toosendan, radix cyathulae, the root of Chinese clematis, ramulus cinnamomi, Radix Angelicae Pubescentis, berba aristolochiae mollissimae, turpentine, pericarpium zanthoxyli, gentianae macrophyllae, capsicum, lycopodium calvatum, lopseed, monkshood, radix aconiti agrestis, caulis trachelospermi, caulis piperis futokadsurae, rhizoma dioscoreae nipponicae, Rhizoma Chuanxiong, radix saposhnikoviae, olibanum, myrrh, member are acted like a bully traditional Chinese medicinal components, and with centipede, scorpio, toad-cortex, Eupolyphoge sinensis, agkistrodon, honeybee, earthworm, Gecko, leech are that raw material extracts insect protein；The each component gives full play to respective pharmacological property, using each ingredient drug effect monarch, minister, The effect of effective cooperation between helping, being allowed to, plays its dispelling cold and removing dampness altogether, dispelling wind and removing obstruction in the meridians has edema caused by wind-dampness, spur strain preferable Therapeutic effect, while having effects that certain kidney tonifying.And the pharmaceutical preparation for the treatment of rheumatic spur strain of the present invention, for Each course of disease rheumatic spur disease has preferable therapeutic effect, and safety is without any side effects.
Specific embodiment
The biological emplastrum of embodiment 1
The bulk pharmaceutical chemicals composition of the biological emplastrum for the treatment of rheumatic spur strain of the present invention includes: tripterygium wilfordii 12kg, ghost Fletching 18kg, thallus laminariae 10kg, Prunella vulgaris 25kg, vinegar turtle shell 10kg, tortoiseshell 15kg, Poria cocos 12kg, rhizoma alismatis 15kg, root of fangji 15kg, Bush 15kg, Radix Salviae Miltiorrhizae 15kg, peach kernel 25kg, safflower 15kg, Radix Angelicae Sinensis 20kg, Fructus meliae toosendan 12kg, radix cyathulae 15kg, the root of Chinese clematis 12kg, ramulus cinnamomi 15kg, Radix Angelicae Pubescentis 10kg, berba aristolochiae mollissimae 20kg, turpentine 10kg, pericarpium zanthoxyli 25kg, gentianae macrophyllae 15kg, capsicum 25kg, lycopodium calvatum 15kg, lopseed 25kg, monkshood 10kg, radix aconiti agrestis 15kg, caulis trachelospermi 12kg, caulis piperis futokadsurae 15kg, rhizoma dioscoreae nipponicae 10kg, Rhizoma Chuanxiong 20kg, Windproof 10kg, olibanum 25kg, myrrh 15kg, corydalis tuber 35kg, insect protein 0.035kg.
The preparation method of the biological emplastrum for the treatment of rheumatic spur strain, includes the following steps: described in the present embodiment
(1) it takes a selected amount of tripterygium wilfordii, Ramulus euonymi, thallus laminariae, Prunella vulgaris, vinegar turtle shell, tortoiseshell, Poria cocos, rhizoma alismatis, prevent Oneself, bush, Radix Salviae Miltiorrhizae, peach kernel, safflower, Radix Angelicae Sinensis, Fructus meliae toosendan, radix cyathulae, the root of Chinese clematis, ramulus cinnamomi, Radix Angelicae Pubescentis, berba aristolochiae mollissimae, turpentine, pericarpium zanthoxyli, Gentianae macrophyllae, capsicum, lycopodium calvatum, lopseed, monkshood, radix aconiti agrestis, caulis trachelospermi, caulis piperis futokadsurae, rhizoma dioscoreae nipponicae, Rhizoma Chuanxiong, radix saposhnikoviae, olibanum, myrrh, member Recklessly, it is crushed after mixing or mix after crushing, crosses 200 meshes, it is spare；
(2) centipede, scorpio, toad-cortex, Eupolyphoge sinensis, white flower are taken according to the mass ratio of 1:2:0.4:1:1:0.5:1:0.8:2 Snake, honeybee, earthworm, gecko, leech are that raw material is mixed and added into after being routinely sieved and removing dust and accounts for 2 times of insect raw material total amount The water of amount carries out decoction extraction, collects filtrate after being centrifuged 10-30min, freezes 4h, then carry out freeze-drying 6h, insect is made Protein freeze-dried powder is saved in -30 DEG C, spare；
(3) gained traditional Chinese medicine powder in step (1) and a selected amount of insect protein freeze-dried powder are mixed, and is added 1000 grams The red chili oil of mastic, 4 Keshan potassium sorbates, 5cc mixes, and booth 4.5cc circle cream is to get required biological emplastrum.
The biological emplastrum of embodiment 2
The bulk pharmaceutical chemicals composition of the biological emplastrum for the treatment of rheumatic spur strain of the present invention includes: tripterygium wilfordii 18kg, ghost Fletching 12kg, thallus laminariae 15kg, Prunella vulgaris 15kg, vinegar turtle shell 15kg, tortoiseshell 10kg, Poria cocos 18kg, rhizoma alismatis 10kg, root of fangji 25kg, Bush 10kg, Radix Salviae Miltiorrhizae 25kg, peach kernel 15kg, safflower 25kg, Radix Angelicae Sinensis 15kg, Fructus meliae toosendan 20kg, radix cyathulae 10kg, the root of Chinese clematis 20kg, ramulus cinnamomi 5kg, Radix Angelicae Pubescentis 15kg, berba aristolochiae mollissimae 15kg, turpentine 15kg, pericarpium zanthoxyli 15kg, gentianae macrophyllae 25kg, capsicum 15kg, lycopodium calvatum 25kg, lopseed 15kg, monkshood 15kg, radix aconiti agrestis 10kg, caulis trachelospermi 18kg, caulis piperis futokadsurae 10kg, rhizoma dioscoreae nipponicae 15kg, Rhizoma Chuanxiong 12kg, Windproof 15kg, olibanum 15kg, myrrh 25kg, corydalis tuber 25kg, insect protein 0.04kg.
The preparation method of the biological emplastrum for the treatment of rheumatic spur strain, includes the following steps: described in the present embodiment
(1) it takes a selected amount of tripterygium wilfordii, Ramulus euonymi, thallus laminariae, Prunella vulgaris, vinegar turtle shell, tortoiseshell, Poria cocos, rhizoma alismatis, prevent Oneself, bush, Radix Salviae Miltiorrhizae, peach kernel, safflower, Radix Angelicae Sinensis, Fructus meliae toosendan, radix cyathulae, the root of Chinese clematis, ramulus cinnamomi, Radix Angelicae Pubescentis, berba aristolochiae mollissimae, turpentine, pericarpium zanthoxyli, Gentianae macrophyllae, capsicum, lycopodium calvatum, lopseed, monkshood, radix aconiti agrestis, caulis trachelospermi, caulis piperis futokadsurae, rhizoma dioscoreae nipponicae, Rhizoma Chuanxiong, radix saposhnikoviae, olibanum, myrrh, member Recklessly, it is crushed after mixing or mix after crushing, crosses 200 meshes, it is spare；
(2) centipede, scorpio, toad-cortex, Eupolyphoge sinensis, white flower are taken according to the mass ratio of 1:2:0.4:1:1:0.5:1:0.8:2 Snake, honeybee, earthworm, gecko, leech are that raw material is mixed and added into after being routinely sieved and removing dust and accounts for 4 times of insect raw material total amount The water of amount carries out decoction extraction, collects filtrate after being centrifuged 10-30min, freezes 4h, then carry out freeze-drying 6h, insect is made Protein freeze-dried powder is saved in -30 DEG C, spare；
(3) gained traditional Chinese medicine powder in step (1) and a selected amount of insect protein freeze-dried powder are mixed, and is added 1000 grams The red chili oil of mastic, 4 Keshan potassium sorbates, 5cc mixes, and booth 4.5cc circle cream is to get required biological emplastrum.
The biological emplastrum of embodiment 3
The bulk pharmaceutical chemicals composition of the biological emplastrum for the treatment of rheumatic spur strain of the present invention includes: tripterygium wilfordii 15kg, ghost Fletching 15kg, thallus laminariae 12kg, Prunella vulgaris 20kg, vinegar turtle shell 12kg, tortoiseshell 12kg, Poria cocos 15kg, rhizoma alismatis 12kg, root of fangji 20kg, Bush 12kg, Radix Salviae Miltiorrhizae 20kg, peach kernel 20kg, safflower 20kg, Radix Angelicae Sinensis 18kg, Fructus meliae toosendan 16kg, radix cyathulae 12kg, the root of Chinese clematis 16kg, ramulus cinnamomi 10kg, Radix Angelicae Pubescentis 12kg, berba aristolochiae mollissimae 18kg, turpentine 12kg, pericarpium zanthoxyli 20kg, gentianae macrophyllae 20kg, capsicum 20kg, lycopodium calvatum 20kg, lopseed 20kg, monkshood 12kg, radix aconiti agrestis 12kg, caulis trachelospermi 15kg, caulis piperis futokadsurae 12kg, rhizoma dioscoreae nipponicae 12kg, Rhizoma Chuanxiong 16kg, Windproof 12kg, olibanum 20kg, myrrh 20kg, corydalis tuber 30kg, insect protein 0.038kg.
The preparation method of the biological emplastrum for the treatment of rheumatic spur strain, includes the following steps: described in the present embodiment
(1) it takes a selected amount of tripterygium wilfordii, Ramulus euonymi, thallus laminariae, Prunella vulgaris, vinegar turtle shell, tortoiseshell, Poria cocos, rhizoma alismatis, prevent Oneself, bush, Radix Salviae Miltiorrhizae, peach kernel, safflower, Radix Angelicae Sinensis, Fructus meliae toosendan, radix cyathulae, the root of Chinese clematis, ramulus cinnamomi, Radix Angelicae Pubescentis, berba aristolochiae mollissimae, turpentine, pericarpium zanthoxyli, Gentianae macrophyllae, capsicum, lycopodium calvatum, lopseed, monkshood, radix aconiti agrestis, caulis trachelospermi, caulis piperis futokadsurae, rhizoma dioscoreae nipponicae, Rhizoma Chuanxiong, radix saposhnikoviae, olibanum, myrrh, member Recklessly, it is crushed after mixing or mix after crushing, crosses 200 meshes, it is spare；
(2) centipede, scorpio, toad-cortex, Eupolyphoge sinensis, white flower are taken according to the mass ratio of 1:2:0.4:1:1:0.5:1:0.8:2 Snake, honeybee, earthworm, gecko, leech are that raw material is mixed and added into after being routinely sieved and removing dust and accounts for 3 times of insect raw material total amount The water of amount carries out decoction extraction, collects filtrate after being centrifuged 10-30min, freezes 4h, then carry out freeze-drying 6h, insect is made Protein freeze-dried powder is saved in -30 DEG C, spare；
(3) gained traditional Chinese medicine powder in step (1) and a selected amount of insect protein freeze-dried powder are mixed, and is added 1000 grams The red chili oil of mastic, 4 Keshan potassium sorbates, 5cc mixes, and booth 4.5cc circle cream is to get required biological emplastrum.
The biological ointment of embodiment 4
The bulk pharmaceutical chemicals composition of the biological emplastrum for the treatment of rheumatic spur strain of the present invention includes: tripterygium wilfordii 13kg, ghost Fletching 16kg, thallus laminariae 11kg, Prunella vulgaris 22kg, vinegar turtle shell 11kg, tortoiseshell 14kg, Poria cocos 13kg, rhizoma alismatis 13kg, root of fangji 18kg, Bush 14kg, Radix Salviae Miltiorrhizae 18kg, peach kernel 22kg, safflower 18kg, Radix Angelicae Sinensis 19kg, Fructus meliae toosendan 14kg, radix cyathulae 13kg, the root of Chinese clematis 14kg, ramulus cinnamomi 12kg, Radix Angelicae Pubescentis 11kg, berba aristolochiae mollissimae 19kg, turpentine 11kg, pericarpium zanthoxyli 22kg, gentianae macrophyllae 18kg, capsicum 22kg, lycopodium calvatum 18kg, lopseed 22kg, monkshood 11kg, radix aconiti agrestis 13kg, caulis trachelospermi 14kg, caulis piperis futokadsurae 13kg, rhizoma dioscoreae nipponicae 11kg, Rhizoma Chuanxiong 18kg, Windproof 11kg, olibanum 22kg, myrrh 18kg, corydalis tuber 32kg, insect protein 0.036kg.
The preparation method of the biological ointment for the treatment of rheumatic spur strain, includes the following steps: described in the present embodiment
(1) it takes a selected amount of tripterygium wilfordii, Ramulus euonymi, thallus laminariae, Prunella vulgaris, vinegar turtle shell, tortoiseshell, Poria cocos, rhizoma alismatis, prevent Oneself, bush, Radix Salviae Miltiorrhizae, peach kernel, safflower, Radix Angelicae Sinensis, Fructus meliae toosendan, radix cyathulae, the root of Chinese clematis, ramulus cinnamomi, Radix Angelicae Pubescentis, berba aristolochiae mollissimae, turpentine, pericarpium zanthoxyli, Gentianae macrophyllae, capsicum, lycopodium calvatum, lopseed, monkshood, radix aconiti agrestis, caulis trachelospermi, caulis piperis futokadsurae, rhizoma dioscoreae nipponicae, Rhizoma Chuanxiong, radix saposhnikoviae, olibanum, myrrh, member Recklessly, it is crushed after mixing or mix after crushing, crosses 200 meshes, it is spare；
(2) centipede, scorpio, toad-cortex, Eupolyphoge sinensis, white flower are taken according to the mass ratio of 1:2:0.4:1:1:0.5:1:0.8:2 Snake, honeybee, earthworm, gecko, leech are that raw material is mixed and added into after being routinely sieved and removing dust and accounts for 2 times of insect raw material total amount The water of amount carries out decoction extraction, collects filtrate after being centrifuged 10-30min, freezes 4h, then carry out freeze-drying 6h, insect is made Protein freeze-dried powder is saved in -30 DEG C, spare；
(3) gained traditional Chinese medicine powder in step (1) and a selected amount of insect protein freeze-dried powder are mixed, is added conventional auxiliary Material, is made clinically acceptable ointment according to common process.
The biological emplastrum of embodiment 5
The bulk pharmaceutical chemicals composition of the biological emplastrum for the treatment of rheumatic spur strain of the present invention includes: tripterygium wilfordii 16kg, ghost Fletching 13kg, thallus laminariae 14kg, Prunella vulgaris 18kg, vinegar turtle shell 13kg, tortoiseshell 11kg, Poria cocos 16kg, rhizoma alismatis 11kg, root of fangji 22kg, Bush 11kg, Radix Salviae Miltiorrhizae 22kg, peach kernel 18kg, safflower 22kg, Radix Angelicae Sinensis 16kg, Fructus meliae toosendan 18kg, radix cyathulae 11kg, the root of Chinese clematis 18kg, ramulus cinnamomi 8kg, Radix Angelicae Pubescentis 13kg, berba aristolochiae mollissimae 16kg, turpentine 13kg, pericarpium zanthoxyli 18kg, gentianae macrophyllae 22kg, capsicum 18kg, lycopodium calvatum 22kg, lopseed 18kg, monkshood 14kg, radix aconiti agrestis 11kg, caulis trachelospermi 16kg, caulis piperis futokadsurae 11kg, rhizoma dioscoreae nipponicae 13kg, Rhizoma Chuanxiong 14kg, Windproof 14kg, olibanum 18kg, myrrh 22kg, corydalis tuber 28kg, insect protein 0.039kg.
The preparation method of the biological emplastrum for the treatment of rheumatic spur strain is the same as embodiment 3 described in the present embodiment.
Experimental example
1, example is treated
Clinic collects the 49 progress clinical observations of patient for being diagnosed as rheumatism, wherein is diagnosed as rheumatoid pass Scorching patient 25 is saved, with spur patient 12, daily lumbar muscle strain patient 8, prolapse of lumbar intervertebral disc patient 4.
The evaluation criterion of clinical therapeutic efficacy are as follows:
(1) clinical cure: original symptom disappears；
(2) effectively: original symptom partial disappearance is mitigated；
(3) invalid: symptom and sign is unchanged.
Medication: biological emplastrum prepared by Example 3 pastes affected part, a daily patch, it is desirable that at least stick 6h, emplastrum Agent reusable 2-3 days, if emplastrum is inviscid, it can remove slightly to heat and stick again, entire therapeutic process was with 10 days One course for the treatment of is treated the 1-3 course for the treatment of according to patient symptom degree and sick time and is differed.
After carrying out the 1-3 course for the treatment of of treatment using biological emplastrum prepared by the embodiment of the present invention 3, above-mentioned 49 patients are observed Treatment condition, be as a result recorded in the following table 1.
1 clinical treatment outcome of table
Toxic side effect: after treatment is finished, every routine inspection, no abnormal change are carried out to reviewing patient.3 months Above-mentioned case is paid a return visit afterwards, no patients with recurrent.
From upper table data it is found that the biological emplastrum for the treatment of rheumatic spur strain of the present invention is to edema caused by wind-dampness, spur Swelling and pain and lumbar muscle strain have preferable therapeutic efficiency, and have preferable function for tonifying kidney, and treatment cycle is shorter, effect compared with It is good.
2, typical case
1, patient records certain, and male, 38 one full year of life of age, clinical diagnosis is rheumatoid arthritis, and the course of disease 2 years or so, the state of an illness was Two thigh bone arthralgia, especially symptom rainy days more very, using emplastrum biological in the embodiment of the present invention 3 carry out treatment 10 days one A course for the treatment of, lesion substantially completely disappear, and the state of an illness controls well, pay a return visit after June, no recurrence, and affected part is without malaise symptoms, action It is unaffected after.
2, patient's clock, male, 45 one full year of life of age, work of bearing a heavy burden at an early age cause lumbar muscle strain serious, and daily waist is frequent Property ache, have once in a while body-stretching etc. movement, that is, will lead to flank pain unbearably, at least need to lie in bed 2 months every year, using this Biological emplastrum carries out treatment 20 days i.e. 2 course for the treatment of in inventive embodiments 3, and waist ache phenomenon substantially weakens, substantially not shadow Daily life and action are rung, 10 days courses for the treatment of of docile are continued, lesion is almost recovered, pays a return visit after March, no recurrence.
3, Mr. Li, female, 47 one full year of life of age, clinical diagnosis rheumatic arthritis, and with spur swelling and pain symptom, Huan Zheguan Section is ached unbearably, and after carrying out treatment 10 days using emplastrum biological in the embodiment of the present invention 3, the state of an illness greatly improves, and continues to use 2 A course for the treatment of, the state of an illness are almost recovered, follow-up after June, no recurrence sign.
4, there are slight prolapse of lumbar intervertebral disc symptom in Zhu, female, 28 one full year of life of age, show because of work sitting and few exercise For soreness of waist and ache in legs after work sitting, and symptom is got worse, and carries out treatment 10 days using emplastrum biological in the embodiment of the present invention 3 Afterwards, the state of an illness is cured completely, is paid a return visit after March, and affected part is without recurrence.
5, at certain, male, 58 one full year of life of age suffers from rheumatic arthritis for many years, and repeatedly treatment cannot eradicate, Relapse rate hair Make, after carrying out treatment 20 days using emplastrum biological in the embodiment of the present invention 3, sb.'s illness took a favorable turn, 10 days courses for the treatment of of continual cure Afterwards, the state of an illness is cured completely, and symptom completely disappears, and is paid a return visit after June, and the state of an illness is without recurrence.
6, it is pungent certain, male, 53 one full year of life of age, lumbar disc herniation for many years, using emplastrum biological in the embodiment of the present invention 3 into After row treatment 20 days, the state of an illness is cured completely, is paid a return visit after 3 months, the state of an illness is without recurrence.
To sum up, pharmaceutical preparation of the present invention has significant therapeutic effect in terms for the treatment of rheumatic spur strain, and controls The treatment period is shorter, and clinical use is without any side effects.
Obviously, the above embodiments are merely examples for clarifying the description, and does not limit the embodiments.It is right For those of ordinary skill in the art, can also make on the basis of the above description it is other it is various forms of variation or It changes.There is no necessity and possibility to exhaust all the enbodiments.And it is extended from this it is obvious variation or It changes still within the protection scope of the invention.

Claims (10)

1. a kind of pharmaceutical composition for treating rheumatic spur strain, which is characterized in that the bulk pharmaceutical chemicals of described pharmaceutical composition form It include: tripterygium wilfordii 12-18 parts by weight, Ramulus euonymi 12-18 parts by weight, thallus laminariae 10-15 parts by weight, Prunella vulgaris 15-25 parts by weight, vinegar Turtle shell 10-15 parts by weight, tortoiseshell 10-15 parts by weight, Poria cocos 12-18 parts by weight, rhizoma alismatis 10-15 parts by weight, root of fangji 15-25 weight Part, bush 10-15 parts by weight, Radix Salviae Miltiorrhizae 15-25 parts by weight, peach kernel 15-25 parts by weight, safflower 15-25 parts by weight, Radix Angelicae Sinensis 15-20 Parts by weight, Fructus meliae toosendan 12-20 parts by weight, radix cyathulae 10-15 parts by weight, root of Chinese clematis 12-20 parts by weight, ramulus cinnamomi 5-15 parts by weight, Radix Angelicae Pubescentis 10-15 parts by weight, berba aristolochiae mollissimae 15-20 parts by weight, turpentine 10-15 parts by weight, pericarpium zanthoxyli 15-25 parts by weight, gentianae macrophyllae 15-25 weight Measure part, capsicum 15-25 parts by weight, lycopodium calvatum 15-25 parts by weight, lopseed 15-25 parts by weight, monkshood 10-15 parts by weight, radix aconiti agrestis 10-15 parts by weight, caulis trachelospermi 12-18 parts by weight, caulis piperis futokadsurae 10-15 parts by weight, rhizoma dioscoreae nipponicae 10-15 parts by weight, Rhizoma Chuanxiong 12-20 weight Measure part, radix saposhnikoviae 10-15 parts by weight, olibanum 15-25 parts by weight, myrrh 15-25 parts by weight, corydalis tuber 25-35 parts by weight, insect protein 0.035-0.04 parts by weight.
2. the pharmaceutical composition for the treatment of rheumatic spur strain according to claim 1, which is characterized in that the pharmaceutical composition Object bulk pharmaceutical chemicals composition include: 15 parts by weight of tripterygium wilfordii, 15 parts by weight of Ramulus euonymi, 12 parts by weight of thallus laminariae, 20 parts by weight of Prunella vulgaris, 12 parts by weight of vinegar turtle shell, 12 parts by weight of tortoiseshell, 15 parts by weight of Poria cocos, 12 parts by weight of rhizoma alismatis, 20 parts by weight of the root of fangji, 12 weight of bush Part, 20 parts by weight of Radix Salviae Miltiorrhizae, 20 parts by weight of peach kernel, 20 parts by weight of safflower, 18 parts by weight of Radix Angelicae Sinensis, 16 parts by weight of Fructus meliae toosendan, radix cyathulae 12 parts by weight, 16 parts by weight of the root of Chinese clematis, 10 parts by weight of ramulus cinnamomi, 12 parts by weight of Radix Angelicae Pubescentis, 18 parts by weight of berba aristolochiae mollissimae, 12 weight of turpentine Part, 20 parts by weight of pericarpium zanthoxyli, 20 parts by weight of gentianae macrophyllae, 20 parts by weight of capsicum, 20 parts by weight of lycopodium calvatum, 20 parts by weight of lopseed, monkshood 12 parts by weight, 12 parts by weight of radix aconiti agrestis, 15 parts by weight of caulis trachelospermi, 12 parts by weight of caulis piperis futokadsurae, 12 parts by weight of rhizoma dioscoreae nipponicae, 16 weight of Rhizoma Chuanxiong Part, windproof 12 parts by weight, 20 parts by weight of olibanum, 20 parts by weight of myrrh, 30 parts by weight of corydalis tuber, 0.038 parts by weight of insect protein.
3. the pharmaceutical composition for the treatment of rheumatic spur strain according to claim 1 or 2, which is characterized in that the insect Albumen is to carry out water as raw material using centipede, scorpio, toad-cortex, Eupolyphoge sinensis, agkistrodon, honeybee, earthworm, gecko, leech to obtain through refining.
4. the pharmaceutical composition for the treatment of rheumatic spur strain according to claim 3, which is characterized in that the centipede, complete Scorpion, toad-cortex, Eupolyphoge sinensis, agkistrodon, honeybee, earthworm, gecko, leech mass ratio be 1:2:0.4:1:1:0.5:1:0.8:2.
5. the use that the described in any item pharmaceutical compositions of claim 1-4 are used to prepare treatment rheumatic spur strain pharmaceutical preparation On the way.
6. customary adjuvant is added, according to clinic made from common process by the described in any item pharmaceutical compositions of claim 1-4 The external preparation of upper acceptable treatment rheumatic spur strain.
7. external preparation according to claim 6, which is characterized in that the external preparation include paste, patch, liniment, Or paint.
8. a kind of method for the external preparation for preparing the treatment rheumatic spur strain of claim 6 or 7, which is characterized in that packet Include following steps:
(1) a selected amount of tripterygium wilfordii, Ramulus euonymi, thallus laminariae, Prunella vulgaris, vinegar turtle shell, tortoiseshell, Poria cocos, rhizoma alismatis, the root of fangji, Soviet Union are taken Wood, Radix Salviae Miltiorrhizae, peach kernel, safflower, Radix Angelicae Sinensis, Fructus meliae toosendan, radix cyathulae, the root of Chinese clematis, ramulus cinnamomi, Radix Angelicae Pubescentis, berba aristolochiae mollissimae, turpentine, pericarpium zanthoxyli, gentianae macrophyllae, Capsicum, lycopodium calvatum, lopseed, monkshood, radix aconiti agrestis, caulis trachelospermi, caulis piperis futokadsurae, rhizoma dioscoreae nipponicae, Rhizoma Chuanxiong, radix saposhnikoviae, olibanum, myrrh, corydalis tuber, powder It crushes, sieves for subsequent use after mixing or mix after broken；
(2) centipede, scorpio, toad-cortex, Eupolyphoge sinensis, agkistrodon, honeybee, earthworm, gecko, the leech is taken to be according to selected mass ratio Raw material adds water to extract, and after collecting filtrate and being freeze-dried, insect protein freeze-dried powder is made, spare；
(3) gained traditional Chinese medicine powder in step (1) and a selected amount of insect protein freeze-dried powder are mixed, customary adjuvant is added, presses Clinically acceptable external preparation is made in more solito technique.
9. the method for the external preparation according to claim 8 for preparing the treatment rheumatic spur strain, which is characterized in that In the step (1), the sifting step was 200 meshes.
10. the method for the external preparation for preparing the treatment rheumatic spur strain according to claim 8 or claim 9, feature It is, the auxiliary material includes potassium sorbate and/or red chili oil.
CN201811177345.9A 2018-10-10 2018-10-10 A kind of pharmaceutical composition and the preparation method and application thereof for treating rheumatic spur strain Pending CN108926705A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101120982A (en) * 2007-08-08 2008-02-13 李金山 Traditional Chinese medicine for treating rheumatism and hyperosteogeny
CN102441151A (en) * 2010-10-15 2012-05-09 陈如登 Medicine composition for treating rheumatoid bone disease and preparation method thereof
WO2016058202A1 (en) * 2014-10-13 2016-04-21 深圳市前海安测信息技术有限公司 Traditional chinese medicine composition for treating rheumatic and rheumatoid arthritis and preparation method for same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101120982A (en) * 2007-08-08 2008-02-13 李金山 Traditional Chinese medicine for treating rheumatism and hyperosteogeny
CN102441151A (en) * 2010-10-15 2012-05-09 陈如登 Medicine composition for treating rheumatoid bone disease and preparation method thereof
WO2016058202A1 (en) * 2014-10-13 2016-04-21 深圳市前海安测信息技术有限公司 Traditional chinese medicine composition for treating rheumatic and rheumatoid arthritis and preparation method for same

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