CN1089140A - Chinese medicine electuary preparation method and the Herb Gynostemmae Pentaphylli total glycosides electuary for preparing with this method - Google Patents
Chinese medicine electuary preparation method and the Herb Gynostemmae Pentaphylli total glycosides electuary for preparing with this method Download PDFInfo
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Abstract
The Herb Gynostemmae Pentaphylli total glycosides electuary that the invention discloses a kind of Chinese medicine electuary preparation method and prepare with this method.Feature is to be raw material with the powdery principal agent, and containing phosphate and do not have sucrose, the ratio of principal agent consumption and adjuvant total amount in the adjuvant is 0.01 to 0.7, and the phosphate consumption is 6-10% of an adjuvant total amount.Herb Gynostemmae Pentaphylli total glycosides electuary (nomenclature of drug is a Herb Gynostemmae Pentaphylli vigor element) is a kind of novel electuary of sucrose-free that is used for the treatment of cardiovascular and cerebrovascular disease.The present invention provides a kind of method for preparing sugar-free medicinal granules for the Chinese medicine industry, provides new drug for not taking the patient who contains sugared medicine.
Description
The present invention relates to the preparation method of improved Chinese medicine electuary and the Herb Gynostemmae Pentaphylli total glycosides electuary for preparing with this method.
China's 89105935.0 patent applications disclose a kind of " preparation method of getting rid of the Chinese medicine electuary of urinary system calculus ", this patent application has been made local improvement to disclosed Chinese medicine electuary preparation method in " pharmaceutics ", belonging to the crude drug is raw material, and the Chinese medicine electuary preparation method that hides sugar is arranged in the adjuvant.
China's 90106302.9 patent applications disclose a kind of " technology to make soaked donkey-hide gelatin infusion ", and its claim 2 records: described Colla Corii Asini means ... the powdery Colla Corii Asini ...This is the electuary preparation technology of raw material with the powdered drug, compares with crude drug decocting and concentrating technology, has the advantage that shortens the production cycle, but has still used white sugar (hiding sugar) in the adjuvant, and the consumption of white sugar and Colla Corii Asini is 1: 1.
Above-mentioned two patent applications all use screening sugar to make adjuvant, because the contained screening sugar of medicine easily causes body fat, and metabolism disorder, unfavorable cardiovascular and cerebrovascular vessel patient's rehabilitation causes children caries, and particularly diabetics can not be taken.Therefore, in order to give full play to Chinese medicine effectiveness to meet clinical needs, it is a realistic problem that should solve that development and production do not contain the Chinese medicine electuary that hides sugar.
It is not difficult to make the feedstock production sugar-free medicinal granules with crude drug.But, as if being raw material, because principal agent purity height if can not choose suitable adjuvant, is difficult to satisfy the requirement of low dose of packing, thereby can not satisfies requirements for clinical application with the powdery principal agent.The present invention once ran into problem how to select adjuvant in trial-production.
China 90106551.X patent application discloses a kind of " prescription of Herb Gynostemmae Pentaphylli oral liquid and technological process ", has disclosed the medicinal component of Herb Gynostemmae Pentaphylli and Herb Gynostemmae Pentaphylli wine, tea, food and the Japanese poliosis therapeutic agent of developing of exploitation." magical Herb Gynostemmae Pentaphylli " literary composition that " China's spark " 1992 the 8th phase 28-29 pages or leaves are delivered has disclosed the existing Herb Gynostemmae Pentaphylli total glycosides tablet of China, Herb Gynostemmae Pentaphylli fitness tablet, three kinds of medicines of Herb Gynostemmae Pentaphylli Lac regis apis and has come into the market.Preliminary search shows, does not see the report of Herb Gynostemmae Pentaphylli total glycosides electuary up to now as yet.
One of purpose of the present invention provides a kind of preparation method of medical Chinese medicine electuary, and this method is raw material with the powdered drug, and the gained medicine does not contain screening sugar, can adapt to the needs of small lot packing and clinical practice.
Two of purpose of the present invention provide a kind of be used for the treatment of cardiovascular and cerebrovascular disease contain the Chinese medicine electuary of Herb Gynostemmae Pentaphylli total glycosides as active constituent, this electuary does not contain and hides sugar, Yi Rong is good to eat.
One of main points of the present invention are that a kind of medical Chinese medicine electuary preparation method is characterized in that: basic composition is of this electuary,
A, adjuvant, wherein the consumption of each component (weight %) is, sodium bicarbonate 48-53%, organic acid 41-47%, phosphate 6-10%, each component consumption (weight) sum is 100%.
B, powdery principal agent (active constituent), the ratio of its consumption and adjuvant total amount (100%) is 0.01 to 0.7.Prepare this electuary
C, may further comprise the steps successively:
With each adjuvant component of above-mentioned powdery principal agent and pulverize separately, cross the 80-100 mesh sieve, mixed together is even, tiling 1-2 cm thick heated 5-20 minute down at 85-95 ℃, and material is clamminess, granulate with 14 mesh sieves, descended dry 0.5-1 hour, with the granular electuary packing of gained at 45-55 ℃.
Described powdery principal agent (active constituent) be can treat cardiovascular and cerebrovascular disease Herb Gynostemmae Pentaphylli total glycosides or the treatment coronary heart disease Ganoderma extract or can promote the microcirculatory Folium Ginkgo extract of blood vessel.
Said phosphate as adjuvant is sodium dihydrogen phosphate or sodium hydrogen phosphate.
Two of main points of the present invention are: the treatment cardiovascular and cerebrovascular disease of a kind of usefulness Chinese medicine electuary provided by the invention preparation method preparation contain the Chinese medicine electuary of Herb Gynostemmae Pentaphylli total glycosides as active constituent, it is characterized in that basic composition is of this electuary:
A, adjuvant, wherein the consumption of each component (weight %) is, sodium bicarbonate 48-53%, organic acid 41-46%, phosphate 6-7%, each component consumption (weight) sum is 100%.
B, powdery principal agent (active constituent) are the following Herb Gynostemmae Pentaphylli total glycosidess of structural formula, and the ratio of its consumption and adjuvant total amount (100%) is 0.01-0.02.
R in the formula
1, R
4: the residue of glucose, rhamnose, xylose, arabinose etc.
R
2：CH
3、CHO、CH
2OH
R
3R
6：H、OH
R
5：CH
2OH
C, described Chinese medicine electuary are a kind of dosage forms of Herb Gynostemmae Pentaphylli, but appellation Herb Gynostemmae Pentaphylli total glycosides electuary, nomenclature of drug is a Herb Gynostemmae Pentaphylli vigor element, the content of Herb Gynostemmae Pentaphylli total glycosides is the 90-110% of labelled amount in the medicine.
The pharmacological research and the clinical research of system prove that Herb Gynostemmae Pentaphylli total glycosides has multiple physiologically active, and its medical value is very high.The inventor just hopes a kind of Herb Gynostemmae Pentaphylli novel form-electuary of exploitation at first, and according to investigating, it is unfavorable to patient that medicine contains screening sugar, so the development sugar-free medicinal granules just becomes inventor's problem.Method of the present invention was the production method of Herb Gynostemmae Pentaphylli sugar-free medicinal granules originally, in order to explore the widespread popularity of this method, had done the test of Ganoderma and Folium Ginkgo extract (powdered drug) preparation sugar-free medicinal granules again.Herb Gynostemmae Pentaphylli total glycosides is the crude drug with approval of authority that Xinyang, Henan Yu Nan pharmaceutical factory provides in the present invention, is faint yellow powder, water soluble.Ganoderma and Folium Ginkgo extract are that south, Henan pharmaceutical factory scientific research institution's laboratory utilizes crude drug to produce according to a conventional method.Test shows that all the inventive method of all can utilizing that belongs to the enough Chinese medicine crude drug extractions of energy powdery principal agent prepare corresponding sugar-free medicinal granules.The consumption of Herb Gynostemmae Pentaphylli total glycosides is determined (stating the embodiment tabular data as follows) according to clinical dosage in the present invention.It is identical with tablet that gained medicine Herb Gynostemmae Pentaphylli vigor element is used for clinical effectiveness.Can the consumption of Ganoderma and Folium Ginkgo extract be more, mainly to be reduce supplementary product consumption in order exploring, thereby to reduce production costs.Evidence, strengthening the principal agent consumption also can pelletizing forming.Ganoderma and Folium Ginkgo product are without clinical practice.
In the present invention, organic acid and sodium bicarbonate and their consumption are all known to one skilled in the art.Contribution of the present invention is to select for use phosphate to make binding agent, does not find as yet in known technical data the adjuvant of phosphate as electuary.Test shows that sodium dihydrogen phosphate and sodium hydrogen phosphate can both satisfy the technological requirement of even pelletizing forming, thereby has realized the purpose of low dose of packing, and the particle diameter of Herb Gynostemmae Pentaphylli vigor element is generally less than 3 millimeters.Phosphatic consumption is if be lower than 6%, and powder is more in the product, and the binding agent deficiency is described.Its consumption is greater than 10%, and for example 12%, the uniformity of product granularity does not have significant change, illustrates manyly to there is no need with adjuvant, may be a kind of waste.In order to improve the uniformity performance of product granularity, the phosphate consumption can be greater than 10%.
Process conditions of the present invention, as spending grit number, temperature, time etc., experimental facilities and field condition are determined according to the present invention, those skilled in the art, can grasp in conjunction with equipment and the on-the-spot reality of oneself according to the prompting of the inventive method.Tile 1-2 centimetre be experimental data, concrete thickness can be determined by test by attemperation and time.
The Chinese medicine electuary that contains Herb Gynostemmae Pentaphylli total glycosides that is used for the treatment of cardiovascular and cerebrovascular disease provided by the invention, i.e. Herb Gynostemmae Pentaphylli total glycosides electuary, nomenclature of drug Herb Gynostemmae Pentaphylli vigor element.The effect of this electuary medicine and curative effect are decided by Herb Gynostemmae Pentaphylli total glycosides in essence.About function and the existing many papers of effect and the monograph of Herb Gynostemmae Pentaphylli total glycosides, also discuss to some extent in the Chinese 90106551.X patent application document of mentioning in the above and " magical Herb Gynostemmae Pentaphylli " literary composition.Herb Gynostemmae Pentaphylli total glycosides electuary of the present invention has embodied due function and curative effect equally.Below provide the pharmacology of Herb Gynostemmae Pentaphylli vigor element, the part example of clinical trial:
1, blood fat reducing: 80 routine hyperlipidemia patients are carried out treatment in three months observe, total effective rate is 95.6%.
2, resisting fatigue: the white mice swimming time is prolonged, and matched group is 9.68 ± 2.63min, and the administration group is 17.47 ± 4.68min.
3, anti-inner feelings is old: in the human body cell culture fluid that contains medicine of the present invention (200Mg/ml), cell can pass for 27 generations, and matched group was 22 generations.
4, strengthen immune function of human body: the patient that 20 routine lupus erythematosus are shown as immunologic dysfunction carry out for the time trimestral treatment observe effective percentage 88.8%.
Medicine of the present invention is thought according to enough pharmacology and clinical trial by health authorities, reasonable recipe, clinical effectively, quality standard is feasible.
Medicine active constituent Determination on content method of the present invention is spectrophotography (the 51st page of appendix of Chinese Pharmacopoeia nineteen ninety version).The content of Herb Gynostemmae Pentaphylli total glycosides is the 90-110% of labelled amount, i.e. the matter of medicine of the present invention reason standard.During clinical practice, take a 30-60mg, three times on the one after mixing it with hot water.
The present invention compares with prior art, has tangible beneficial effect.At first, the present invention adopts phosphate to make binding agent, does not have the sugar of screening in the adjuvant, for the Chinese medicine industry provides effective sugar-free Chinese medicine electuary preparation method.Secondly the present invention provides a kind of novel form for the application of Herb Gynostemmae Pentaphylli, and is sugar-free medicinal granules, can not take the patient who contains sugared Herb Gynostemmae Pentaphylli medicine for those convenience is provided.
Embodiment 1 to 4, and their component and consumption and main technologic parameters see Table 1, in the composition correctives can be arranged, as protein sugar, stevioside.Each example is 1000 bag packing in the table.In the example 1 to 4, the ratio of the consumption of its powdery principal agent and adjuvant total amount is 0.01,0.02,0.33,0.66 in order.The percentage by weight of phosphate in adjuvant is respectively 6%, 7%, 8%, 10%.
Claims (4)
1, a kind of medical Chinese medicine electuary preparation method is characterized in that: basic composition is of this electuary
A, adjuvant, wherein the consumption of each component (weight %) is, sodium bicarbonate 43-53%, organic acid 41-47%, phosphate 6-10%, each component consumption (weight) sum is 100%
B, powdery principal agent (active constituent), the ratio of its consumption and adjuvant total amount (100%) is 0.01 to 0.7, prepares this electuary
C, may further comprise the steps successively,
With each adjuvant component of above-mentioned powdery principal agent and pulverize separately, cross 80 to 100 mesh sieves, mixed together is even, tiling 1-2 cm thick heated 5-20 minute down at 85-95 ℃, and material is clamminess, granulate with 14 mesh sieves, descended dry 0.5-1 hour, with the granular electuary packing of gained at 45-55 ℃.
2, the method for claim 1, it is characterized in that, said powdery principal agent (active constituent) be can treat cardiovascular and cerebrovascular disease Herb Gynostemmae Pentaphylli total glycosides or the treatment coronary heart disease Ganoderma extract or can promote the microcirculatory Folium Ginkgo extract of blood vessel.
3, method as claimed in claim 1 or 2 is characterized in that, said phosphate as adjuvant is sodium dihydrogen phosphate or sodium hydrogen phosphate.
4, a kind of treatment cardiovascular and cerebrovascular disease with the preparation of the described method of claim 1 contain the Chinese medicine electuary of Herb Gynostemmae Pentaphylli total glycosides as active constituent, it is characterized in that basic composition is of this electuary:
A, adjuvant, wherein the consumption of each component (weight %) is, sodium bicarbonate 48-53%, organic acid 41-46%, phosphate 6-7%, each component consumption (weight) sum is 100%,
B, powdery principal agent (active constituent) are the following Herb Gynostemmae Pentaphylli total glycosidess of structural formula, and the ratio of its consumption and adjuvant total amount (100%) is 0.01-0.02,
R in the formula
1, R
4: the residue of glucose, rhamnose, xylose, arabinose etc.,
R
2：CH
3、CHO、CH
2OH
R
3R
6：H、OH
R
5：CH
2OH
C, described Chinese medicine electuary are a kind of dosage forms of Herb Gynostemmae Pentaphylli, but appellation Herb Gynostemmae Pentaphylli total glycosides electuary, nomenclature of drug is a Herb Gynostemmae Pentaphylli vigor element, the content of Herb Gynostemmae Pentaphylli total glycosides is the 90-110% of labelled amount in the medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93108934 CN1089140A (en) | 1993-07-17 | 1993-07-17 | Chinese medicine electuary preparation method and the Herb Gynostemmae Pentaphylli total glycosides electuary for preparing with this method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93108934 CN1089140A (en) | 1993-07-17 | 1993-07-17 | Chinese medicine electuary preparation method and the Herb Gynostemmae Pentaphylli total glycosides electuary for preparing with this method |
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| CN1089140A true CN1089140A (en) | 1994-07-13 |
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| CN 93108934 Pending CN1089140A (en) | 1993-07-17 | 1993-07-17 | Chinese medicine electuary preparation method and the Herb Gynostemmae Pentaphylli total glycosides electuary for preparing with this method |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104000865A (en) * | 2014-06-13 | 2014-08-27 | 沈阳农业大学 | Taurine compound preparation with blood fat reducing function and blood sugar reducing function |
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1993
- 1993-07-17 CN CN 93108934 patent/CN1089140A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104000865A (en) * | 2014-06-13 | 2014-08-27 | 沈阳农业大学 | Taurine compound preparation with blood fat reducing function and blood sugar reducing function |
| CN104000865B (en) * | 2014-06-13 | 2017-08-04 | 沈阳农业大学 | It is a kind of that there is reducing blood lipid, the Taurine of function of blood sugar reduction |
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| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |