CN108912208A - A kind of adjustable Solid-phase synthesis peptides device of temperature - Google Patents
A kind of adjustable Solid-phase synthesis peptides device of temperature Download PDFInfo
- Publication number
- CN108912208A CN108912208A CN201810634739.6A CN201810634739A CN108912208A CN 108912208 A CN108912208 A CN 108912208A CN 201810634739 A CN201810634739 A CN 201810634739A CN 108912208 A CN108912208 A CN 108912208A
- Authority
- CN
- China
- Prior art keywords
- autoclave body
- temperature
- unit
- phase synthesis
- rotary shaft
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 22
- 102000004196 processed proteins & peptides Human genes 0.000 title claims abstract description 19
- 238000010532 solid phase synthesis reaction Methods 0.000 title claims abstract description 19
- 238000003756 stirring Methods 0.000 claims abstract description 38
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims description 26
- 239000007788 liquid Substances 0.000 claims description 15
- 229910052697 platinum Inorganic materials 0.000 claims description 13
- 238000007599 discharging Methods 0.000 claims description 11
- 238000005086 pumping Methods 0.000 claims description 11
- 230000010412 perfusion Effects 0.000 claims description 9
- 239000007787 solid Substances 0.000 claims description 8
- 239000011248 coating agent Substances 0.000 claims description 6
- 238000000576 coating method Methods 0.000 claims description 6
- 238000005260 corrosion Methods 0.000 claims description 6
- 230000007797 corrosion Effects 0.000 claims description 6
- 238000010438 heat treatment Methods 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 5
- 238000000967 suction filtration Methods 0.000 claims description 5
- 238000003466 welding Methods 0.000 claims description 3
- 238000012423 maintenance Methods 0.000 abstract description 7
- 238000006243 chemical reaction Methods 0.000 description 25
- 238000000034 method Methods 0.000 description 11
- 239000000463 material Substances 0.000 description 6
- 150000001413 amino acids Chemical class 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000003786 synthesis reaction Methods 0.000 description 4
- 239000012535 impurity Substances 0.000 description 3
- 239000000376 reactant Substances 0.000 description 3
- 230000000903 blocking effect Effects 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 230000012782 tube fusion Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
Abstract
The invention discloses a kind of adjustable Solid-phase synthesis peptides devices of temperature, including autoclave body, the autoclave body upper end is equipped with feed inlet, the lower end of the autoclave body is equipped with discharge port, agitating unit is equipped in the autoclave body, the agitating unit includes multiple agitating devices, the agitating device includes rotary sleeve axis, the rotary sleeve axis includes rotary shaft and the drive shaft that is set in rotary shaft, driving unit outside the drive shaft both ends connection autoclave body, it uniformly arranges on the periphery of the rotary shaft several stirring blades, the external vacuum unit in autoclave body lower end, control temperature unit is equipped in the autoclave body.The design structure is simply clear, is closely connected and does not influence each other between each component, and required part replacement is convenient, is easy to the maintenance of product in use in the future.
Description
Technical field
The present invention relates to chemical device fields, and in particular to a kind of adjustable Solid-phase synthesis peptides device of temperature.
Background technique
Solid-phase synthesis peptides are that protected amino acid is connected on solid resin, slough blocking group, then will be next
Protected amino acid reacts with the residue of first amino acid and is formed peptide bond, then sloughs the blocking group of second amino acid,
Next amino acid is reconnected, circulation goes down to make peptide chain growth in this way.In Solid-phase synthesis peptides, solid resin is must to use
Reaction substrate.In Solid-phase synthesis peptides reaction, temperature has a very big impact the result of synthesis, makes in the prior art
Peptide systhesis device is synthesized according to the temperature outside instrument mostly, and synthetic effect is not satisfactory, or there are controllable temperatures
Instrument, but have that structure is complicated, the problem of higher cost, therefore urgently those skilled in the art solve the problems, such as this.
Summary of the invention
To solve the above problems, the invention discloses a kind of adjustable Solid-phase synthesis peptides device of temperature, its object is to
Solve the problems, such as that temperature control higher cost during Peptide systhesis, structure is complicated.
In order to reach the goals above, the present invention provides the following technical solutions：A kind of adjustable Solid-phase synthesis peptides dress of temperature
It sets, including autoclave body, the autoclave body upper end is equipped with feed inlet, and the lower end of the autoclave body is equipped with discharge port, is equipped with and stirs in the autoclave body
Unit is mixed, the agitating unit includes multiple agitating devices, and the agitating device includes rotary sleeve axis, the rotary sleeve axis packet
The drive shaft for including rotary shaft and being set in rotary shaft, the drive shaft both ends connect the driving unit outside autoclave body, the rotation
The center line of shaft and the center line of autoclave body are mutually perpendicular to, and the center line of each rotary shaft is parallel to each other, the rotary shaft
It uniformly arranges on periphery several stirring blades, the stirring blade includes solid stirring blade and mesh stirring blade, the kettle
The external vacuum unit in body lower end, the autoclave body is interior to be equipped with control temperature unit, and the control temperature unit includes temperature-controlled tube, the temperature control
Platinum resistance is embedded in pipe, the platinum resistance connects power supply by heating control circuit and realizes that temperature controls, outside the temperature-controlled tube
End connection liquid sucking-discharging unit, the liquid sucking-discharging unit includes perfusion tube and for being exported and being inputted liquid medium
Liquid sucking-discharging two-way pump, the perfusion tube are equipped with switch valve.The design structure is simply clear, be closely connected between each component and
It does not influence each other, required part replacement is convenient, is easy to the maintenance of product in use in the future, by reaction kettle
Design agitating unit in vivo, overcomes the lower problem of current reaction efficiency, the center line and kettle of the rotary shaft in agitating unit
The center line of body is mutually perpendicular to, and the center line of each rotary shaft is parallel to each other, if uniformly arranging on the periphery of the rotary shaft
Dry stirring blade, the stirring blade are equipped with several mesh, can guarantee that agitating shaft is firmly secured in whipping process
In autoclave body, the unstable problem of device during the reaction is avoided；By in stirring blade include mesh stirring blade with
Solid stirring blade is used in combination, and be can be realized the reactant in whipping process and is sufficiently mixed, stirs, and cooperation vacuumizes list
The intracorporal air of reaction kettle is evacuated by member during the reaction, builds the environment convenient for reaction, and multiple stirring dresses are arranged
It sets and the material of autoclave body lower end is avoided to be deposited on lower end, on the other hand can be avoided material reaction and go out other impurities, influence finished product
Quality；By the way that control temperature unit is arranged in autoclave body, realizing temperature control in synthesis process, cost is relatively low, structure is simple, temperature control
Efficiently effect is obvious for mode, and platinum resistance is cheap, and convenient for maintenance and replacement that the later period uses, platinum resistance passes through heating control
Circuit connection power supply processed realizes temperature control, and control mode is quick, can be avoided the problem of temperature can not be transmitted in time.
As an improvement of the present invention, the vacuum unit includes vacuum-pumping tube and vacuum pumping pump, described to vacuumize
Pipe is equipped with control switch.
As an improvement of the present invention, the stirring blade is fixed on the rotary shaft by welding.
As an improvement of the present invention, it uses and is threadedly coupled between the temperature-controlled tube and perfusion tube.
As an improvement of the present invention, the outer layer of the temperature-controlled tube is coated with one layer of good corrosion-resistant coating of thermal conductivity.It leads
Hot good corrosion-resistant coating is able to extend the service life of temperature-controlled tube and integral device, has practicability.
As an improvement of the present invention, the lower end of the autoclave body, which is equipped with, filters unit, and the suction filtration unit includes filtering
Plate is fixed by the bracket on autoclave body between suction filtration plate and the autoclave body.Filtering unit and the intracorporal agitating unit cooperation of kettle makes
With reaction efficiency is high, finished product purity is high.
As an improvement of the present invention, agitating device there are two being set in the autoclave body.
As an improvement of the present invention, the diameter of the mesh is 2~5mm.
The opposite and prior art, the invention has the advantages that：
1) design structure is simply clear, is closely connected and does not influence each other between each component, and required part replacement is convenient,
It is easy to the maintenance of product in use in the future, by designing agitating unit in reaction kettle body, overcomes anti-at present
The problem that efficiency is lower is answered, the center line of the rotary shaft in agitating unit and the center line of autoclave body are mutually perpendicular to, each rotation
The center line of axis is parallel to each other, and several stirring blades of uniformly arranging on the periphery of the rotary shaft, the stirring blade is equipped with
Several mesh can guarantee that agitating shaft is firmly secured in autoclave body in whipping process, avoid device during the reaction
Unstable problem；By designing mesh on stirring blade, it can be realized the reactant in whipping process and be sufficiently mixed, stir
It mixes, the intracorporal air of reaction kettle is evacuated by cooperation vacuum unit during the reaction, builds the ring convenient for reaction
Border is arranged multiple agitating devices and the material of autoclave body lower end is avoided to be deposited on lower end, on the other hand can be avoided material reaction and go out it
His impurity, influences the quality of finished product；By the way that control temperature unit is arranged in autoclave body, realizes temperature in synthesis process and control cost
Lower, structure is simple, efficiently effect is obvious for temperature control method, and platinum resistance is cheap, the maintenance used convenient for the later period with more
It changes, platinum resistance connects power supply by heating control circuit and realizes that temperature controls, and control mode is quick, and can be avoided temperature cannot
The problem of enough transmitting in time；
2) the good corrosion-resistant coating of thermal conductivity is able to extend the service life of temperature-controlled tube and integral device, has practical
Property；
3) it filters unit to be used cooperatively with the intracorporal agitating unit of kettle, reaction efficiency is high, finished product purity is high；
4) cost is relatively low for the design scheme, convenient for the popularization and use of medium-sized and small enterprises.
Detailed description of the invention
Fig. 1 is a kind of adjustable Solid-phase synthesis peptides device overall structure diagram of temperature of the present invention；
Fig. 2 is agitating unit structural schematic diagram of the present invention；
Reference signs list：1, autoclave body；2, feed inlet；3, discharge port；4, agitating unit；5, agitating device；501, it rotates
Cover axis；5011, rotary shaft；5012, drive shaft；6, driving unit；7, stirring blade；701, solid stirring blade；702, mesh
Stirring blade；7021, mesh；8, vacuum unit；801, vacuum-pumping tube；802, vacuum pumping pump；803, control switch；9, it controls
Warm unit；901, temperature-controlled tube；902, platinum resistance；10, liquid sucking-discharging unit；1001, perfusion tube；1002, liquid sucking-discharging two-way pump；
1003, switch valve；11, unit is filtered；1101, plate is filtered；1102, bracket；12, screw thread.
Specific embodiment
In order to which technical problems, technical solutions and advantages to be solved are more clearly understood, tie below
Accompanying drawings and embodiments are closed, the present invention will be described in further detail.It should be appreciated that specific embodiment described herein is only
Only to explain the present invention, it is not intended to limit the present invention.
It should be noted that it can be directly another when element is referred to as " being fixed on " or " being set to " another element
On one element or indirectly on another element.When an element is known as " being connected to " another element, it can
To be directly to another element or be indirectly connected on another element.
It is to be appreciated that term " length ", " width ", "upper", "lower", "front", "rear", "left", "right", "vertical",
The orientation or positional relationship of the instructions such as "horizontal", "top", "bottom" "inner", "outside" is that orientation based on the figure or position are closed
System, is merely for convenience of description of the present invention and simplification of the description, rather than the device or element of indication or suggestion meaning must have
Specific orientation is constructed and operated in a specific orientation, therefore is not considered as limiting the invention.
In addition, term " first ", " second " are used for descriptive purposes only and cannot be understood as indicating or suggesting relative importance
Or implicitly indicate the quantity of indicated technical characteristic.Define " first " as a result, the feature of " second " can be expressed or
Person implicitly includes one or more of the features.In the description of the present invention, the meaning of " plurality " is two or two with
On, unless otherwise specifically defined.
Embodiment 1：Referring to Fig. 1 and Fig. 2, now to a kind of adjustable Solid-phase synthesis peptides device of temperature provided by the invention
It is illustrated, including autoclave body 1,1 upper end of autoclave body is equipped with feed inlet 2, and the lower end of the autoclave body 1 is equipped with discharge port 3, described
Agitating unit 4 is equipped in autoclave body 1, the agitating unit 4 includes multiple agitating devices 5, and the agitating device 5 includes rotary sleeve
Axis 501, the rotary sleeve axis 501 include rotary shaft 5011 and the drive shaft 5012 being set in rotary shaft 5011, the drive
5012 both ends of moving axis connect the driving unit 6 outside autoclave body 1, and the center line of the center line and autoclave body 1 of the rotary shaft 5011 is mutual
Vertically, the center line of each rotary shaft 5011 is parallel to each other, several stirrings of uniformly arranging on the periphery of the rotary shaft 5011
Blade 7, the stirring blade 7 include solid stirring blade 701 and mesh stirring blade 702, the external pumping in 1 lower end of autoclave body
Vacuum unit 8, the autoclave body 1 is interior to be equipped with control temperature unit 9, and the control temperature unit 9 includes temperature-controlled tube 901, the temperature-controlled tube 901
It is inside embedded with platinum resistance 902, the platinum resistance 902 realizes temperature by heating control circuit connection power supply (unmarked in figure)
Control, 901 outer end of temperature-controlled tube connect liquid sucking-discharging unit 10, and the liquid sucking-discharging unit 10 includes perfusion tube 1001 and uses
In the liquid sucking-discharging two-way pump 1002 that liquid medium is exported and inputted, the perfusion tube 1001 is equipped with switch valve 1003.
The design structure is simply clear, is closely connected and does not influence each other between each component, and required part replacement is convenient, is easy in the future
The maintenance of product in use, by designing agitating unit in reaction kettle body, overcome current reaction efficiency compared with
Low problem, the center line of rotary shaft and the center line of autoclave body in agitating unit are mutually perpendicular to, the center of each rotary shaft
Line is parallel to each other, several stirring blades of uniformly arranging on the periphery of the rotary shaft, and the stirring blade is equipped with several nets
Hole can guarantee that agitating shaft is firmly secured in autoclave body in whipping process, it is unstable to avoid device during the reaction
The problem of；It is used in combination by stirring blade including mesh stirring blade with solid stirring blade, can be realized and stirring
Reactant is sufficiently mixed, stirs during mixing, and cooperates vacuum unit, and during the reaction, the intracorporal air of reaction kettle is taken out
At vacuum, the environment convenient for reaction is built, multiple agitating devices is set, the material of autoclave body lower end is avoided to be deposited on lower end, it is another
Aspect can be avoided material reaction and go out other impurities, influence the quality of finished product；By the way that control temperature unit is arranged in autoclave body, realize
Cost is relatively low, structure is simple, efficiently effect is obvious temperature control method for temperature control in synthesis process, and platinum resistance is cheap,
Convenient for maintenance and replacement that the later period uses, platinum resistance connects power supply by heating control circuit and realizes that temperature controls, control mode
Fast, it can be avoided the problem of temperature can not be transmitted in time.
Embodiment 2：Referring to Fig. 1, as an improvement of the present invention, the vacuum unit 8 includes 801 He of vacuum-pumping tube
Vacuum pumping pump 802, the vacuum-pumping tube 801 are equipped with control switch 803.
Embodiment 3：Referring to fig. 2, as an improvement of the present invention, the stirring blade 7 is fixed by welding
In rotary shaft 5011.
Embodiment 4：Referring to Fig. 1, as an improvement of the present invention, adopted between the temperature-controlled tube 901 and perfusion tube 1001
It is connected with screw thread 12.
Embodiment 5：Referring to Fig. 1, as an improvement of the present invention, the outer layer of the temperature-controlled tube 9 is coated with one layer of thermal conductivity
Good corrosion-resistant coating.The good corrosion-resistant coating of thermal conductivity is able to extend the service life of temperature-controlled tube and integral device, has
Practicability.
Embodiment 6：Referring to Fig. 1, as an improvement of the present invention, the lower end of the autoclave body 1, which is equipped with, filters unit 11, institute
Stating and filtering unit 11 includes filtering plate 1101, is fixed on autoclave body 1 by bracket 1102 between the suction filtration plate 1101 and autoclave body 1
On.It filters unit to be used cooperatively with the intracorporal agitating unit of kettle, reaction efficiency is high, finished product purity is high.
Embodiment 7：Referring to Fig. 1, as an improvement of the present invention, set in the autoclave body 1 there are two agitating device 5.
Embodiment 8：Referring to Fig. 1 and Fig. 2, as an improvement of the present invention, the diameter of the mesh 7021 is 2~5mm.
The present invention can also be by least one of described technical characteristic of embodiment 2,3,4,5,6,7,8 and example 1 group
Conjunction forms new embodiment.
Control circuit is the prior art, and it is not this that the logic judgment and execution function of itself, which also belong to the prior art,
The innovative point of invention, the present invention are only subject to control circuit as the module that hardware connects using, control circuit and its
The direct connection relationship of its component is only the inventive point of the invention to be protected.
The technical means disclosed in the embodiments of the present invention is not limited only to technological means disclosed in above embodiment, further includes
Technical solution consisting of any combination of the above technical features.It should be pointed out that for those skilled in the art
For, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications also regard
For protection scope of the present invention.
Claims (8)
1. a kind of adjustable Solid-phase synthesis peptides device of temperature, including autoclave body, it is characterised in that：The autoclave body upper end is equipped with charging
Mouthful, the lower end of the autoclave body is equipped with discharge port, and agitating unit is equipped in the autoclave body, and the agitating unit includes multiple stirring dresses
It sets, the agitating device includes rotary sleeve axis, and the rotary sleeve axis includes rotary shaft and the drive shaft that is set in rotary shaft,
Driving unit outside the drive shaft both ends connection autoclave body, the center line of the rotary shaft and the center line of autoclave body are mutually perpendicular to,
The center line of each rotary shaft is parallel to each other, several stirring blades of uniformly arranging on the periphery of the rotary shaft, the stirring
Blade includes solid stirring blade and mesh stirring blade, the external vacuum unit in autoclave body lower end, is equipped in the autoclave body
Control temperature unit, the control temperature unit include temperature-controlled tube, and platinum resistance is embedded in the temperature-controlled tube, and the platinum resistance passes through heating control
Circuit connection power supply processed realizes temperature control, and the temperature-controlled tube outer end connects liquid sucking-discharging unit, and the liquid sucking-discharging unit includes defeated
Liquid pipe and liquid sucking-discharging two-way pump for being exported and being inputted liquid medium, the perfusion tube are equipped with switch valve.
2. the adjustable Solid-phase synthesis peptides device of a kind of temperature according to claim 1, it is characterised in that：It is described to vacuumize
Unit includes vacuum-pumping tube and vacuum pumping pump, and the vacuum-pumping tube is equipped with control switch.
3. the adjustable Solid-phase synthesis peptides device of a kind of temperature according to claim 2, it is characterised in that：The paddle
Piece is fixed on the rotary shaft by welding.
4. the adjustable Solid-phase synthesis peptides device of a kind of temperature according to claim 3, it is characterised in that：The temperature-controlled tube
It uses and is threadedly coupled between perfusion tube.
5. the adjustable Solid-phase synthesis peptides device of a kind of temperature according to claim 3, it is characterised in that：The temperature-controlled tube
Outer layer be coated with one layer of good corrosion-resistant coating of thermal conductivity.
6. the adjustable Solid-phase synthesis peptides device of a kind of temperature according to claim 3, it is characterised in that：The autoclave body
Lower end, which is equipped with, filters unit, and the suction filtration unit includes filtering plate, is fixed by the bracket between suction filtration plate and the autoclave body in kettle
On body.
7. the adjustable Solid-phase synthesis peptides device of a kind of temperature according to claim 4, it is characterised in that：In the autoclave body
If there are two agitating devices.
8. the adjustable Solid-phase synthesis peptides device of a kind of temperature according to claim 1, it is characterised in that：The mesh
Diameter is 2 ~ 5mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810634739.6A CN108912208A (en) | 2018-06-20 | 2018-06-20 | A kind of adjustable Solid-phase synthesis peptides device of temperature |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810634739.6A CN108912208A (en) | 2018-06-20 | 2018-06-20 | A kind of adjustable Solid-phase synthesis peptides device of temperature |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108912208A true CN108912208A (en) | 2018-11-30 |
Family
ID=64422184
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810634739.6A Pending CN108912208A (en) | 2018-06-20 | 2018-06-20 | A kind of adjustable Solid-phase synthesis peptides device of temperature |
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| Country | Link |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024058924A1 (en) * | 2022-09-16 | 2024-03-21 | Cem Corporation | Peptide synthesis processes |
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| US20170226152A1 (en) * | 2015-10-23 | 2017-08-10 | Cem Corporation | Solid phase peptide synthesis |
| CN208883753U (en) * | 2018-06-20 | 2019-05-21 | 南京肽业生物科技有限公司 | A kind of adjustable Solid-phase synthesis peptides device of temperature |
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2018
- 2018-06-20 CN CN201810634739.6A patent/CN108912208A/en active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7132531B1 (en) * | 1999-04-28 | 2006-11-07 | Avecia Limited | Reactor |
| KR20090126779A (en) * | 2008-06-05 | 2009-12-09 | 애니젠 주식회사 | Peptide synthesizer |
| CN204746155U (en) * | 2015-05-30 | 2015-11-11 | 蔡宝塔 | But temperature regulation's mixer |
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| RJ01 | Rejection of invention patent application after publication | ||
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Application publication date: 20181130 |