CN108904621A - 一种蕲艾抑菌洗液及其制备方法 - Google Patents
一种蕲艾抑菌洗液及其制备方法 Download PDFInfo
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Abstract
本发明提供了一种蕲艾抑菌洗液及其制备方法，所述蕲艾抑菌洗液主要包括以下重量百分比的原料组分：蕲艾提取物4‑8％，艾叶挥发油0.1‑0.5％，白鲜皮提取物0.5‑2％，苦参提取物0.5‑3.5％，PEG400 6‑10％，三氯生0.05‑0.5％，水75‑85％。本发明蕲艾抑菌洗液将蕲艾、白鲜皮和苦参进行配伍，各药协同发挥作用，具有清热燥湿，杀虫止痒的功效，可用于女性私处日常的清洁保养，卫生护理及私处冲洗，能有效抑制金黄色葡萄菌、大肠杆菌和白色念珠菌等致病菌的生长繁殖，消除异味，防治妇科炎症的发生，不易复发，提高生殖器官的生理功能。
Description
技术领域
本发明涉及卫生用品领域，具体涉及一种蕲艾抑菌洗液及其制备方法。
背景技术
妇科炎症是女性生殖器出现炎症的一种疾病，类型主要分为宫颈炎、外阴炎、阴道炎以及盆腔炎等。资料显示，全球每年大约15％的妇科肿瘤都是由炎症感染所诱发，且在成年女性中，妇科炎症患病率高达80％以上。妇科炎症病情复杂，治疗难度大，容易复发，给女性的生理和心理带来了双重困扰，如果不及时控制和治疗，会给患者的健康及生活质量造成严重影响。
女性生殖器官的生理结构较为特殊，容易受到排泄物和外界的污染，不易于清洁和干燥，为各类细菌的滋生提供了温床。致病菌的滋生打破了生殖器官原有菌群的平衡系统，影响了生殖器官自净和排除阴道废物的功能，容易造成妇科炎症的发生。目前用于治疗或护理生殖器官的洗液比较多，但主要成分多为抗生素等强效杀菌剂，杀菌效果迅速，但抑菌杀菌种类较单一，容易产生耐药性。且强效杀菌剂会对生殖器官产生化学性刺激，破坏生殖器官的pH环境，容易造成过敏和炎症反复发作。
妇科炎症以中医理论解释属湿热下注，用清热燥湿、泻火解毒、杀虫止痒的中药，可达到抑菌消炎的目的。与常用的抑菌抗炎药物相比，中药具有抑菌谱广，作用温和，毒副作用小，不易破坏生殖器官自净机制的优点，越来越引起人们的重视。据统计我国超过4亿女性要涉及到妇科用药，该领域预防和治疗药物市场需求大，故开发一种抑菌作用明显且毒副作用小的中药抑菌洗液，具有广阔的市场需求和发展前景。
发明内容
为了解决现有缺少抑菌效果明显且毒副作用小的洗护产品的问题，本发明的技术方案如下：
一种蕲艾抑菌洗液，包括以下重量百分比的组分：蕲艾叶4-8％，艾叶挥发油0.1-0.5％，白鲜皮提取物0.5-2％，苦参提取物0.5-3.5％，PEG400 6-10％，三氯生0.05-0.5％，水75-85％。
优选的，包括以下重量百分比的组分：蕲艾叶4％，艾叶挥发油0.1％，白鲜皮提取物0.5％，苦参提取物0.5％，PEG400 6％，三氯生0.05％，水88.85％。
优选的，包括以下重量百分比的组分：蕲艾叶6％，艾叶挥发油0.3％，白鲜皮提取物1％，苦参提取物2％，PEG400 8％，三氯生0.2％，水82.5％。
优选的，包括以下重量百分比的组分：蕲艾叶8％，艾叶挥发油0.5％，白鲜皮提取物1.5％，苦参提取物3.5％，PEG400 10％，三氯生0.5％，水76％。
蕲艾，为菊科植物艾的干燥叶，以湖北蕲春产者最佳，故名“蕲艾”，誉为道地药材。蕲艾内服理气血、逐寒湿、温经止血、安胎，外用可治皮肤瘙痒、阴痒湿疹，具有抗炎、镇痛、抗过敏、镇咳平喘等多种药理活性，其挥发油、总黄酮含量、药理药效等均明显优于其他地区所产艾叶。研究表明艾叶挥发油为其主要的药效成分，对常见的大肠杆菌、金黄色葡萄球菌、变形杆菌和甲型链球菌等均有抑制作用，抗菌谱广，抑菌作用强。蕲艾水提物能一定程度抑制金黄色葡萄球菌、大肠杆菌和白色念珠菌等细菌的生长繁殖，也具有明显的抑菌作用。
白鲜皮，为芸香科白鲜属植物白鲜的干燥根皮，性苦、寒，归脾、胃、膀胱经，具有清热燥湿，祛风解毒功能，常用于湿热疮毒，湿疹，风疹，疥癣疮癞，黄疸尿赤等症。现代研究表明其具有抗菌、抗肿瘤、抗炎、抗溃疡、抗冠状动脉粥样硬化和护肝等药理活性，在抗菌方面作用明显，对多种细菌真菌均有抑制作用。
苦参，为常用中药，其性苦味寒，具有清热燥湿，祛风杀虫，利尿的功能，中医上用于热痢、赤白带下、阴痒、湿疹、皮肤瘙痒等症，外用可用于治滴虫性阴道炎。现代药理研究显示，其所含的生物碱和黄酮类成分均有较好的抑菌抗炎作用，对金黄色葡萄球菌，白色念珠菌和大肠杆菌等均有较强的抑制作用。
本发明抑菌洗液主要由蕲艾的艾叶提取物和艾叶油、白鲜皮、苦参等组成，各药组合在一起可产生协同作用，发挥中药复方整体调节优势，具有清热燥湿，杀虫止痒，祛风解毒的功效，能较好地抑制多种细菌的生长繁殖，对金黄色葡萄球菌，白色念珠菌和大肠杆菌等均有较强的抑制作用。
本发明还提供了一种蕲艾抑菌洗液的制备方法，包括以下步骤：
(1)按比例称取蕲艾叶，置于多功能提取罐中，加入10-20倍的水浸泡20-60min，加热90-100℃、回流提取1-3h，收集艾叶挥发油，水液滤过，滤液放置备用；
(2)收集滤渣，再加8-12倍水回流提取20-60min，温度不低于60℃条件下过滤，收集滤液并与步骤(1)滤液合并，减压浓缩至浓度0.25-0.35g/ml，4-6℃冷藏12-36h除杂，滤过，收集滤液即为艾叶提取液，备用；
(3)按比例称取白鲜皮提取物、苦参提取物，加入到步骤(2)得到的艾叶提取液中，搅匀，滤过；
(4)按比例称取三氯生、艾叶挥发油和PEG400中，并将加入三氯生和艾叶挥发油加入到PEG400溶液中分散，搅匀；
(5)将步骤(3)制得的提取液慢慢加入到步骤(4)得到的PEG400混合溶液中，搅匀，静置，即得蕲艾抑菌洗液。
本发明蕲艾抑菌洗液的制备方法，容易实施，条件控制有利于提取蕲艾提取物及各组分配伍、药效的协同发挥作用。制得的蕲艾抑菌洗液具有清热燥湿，杀虫止痒的功效，可用于女性私处日常的清洁保养，卫生护理及私处冲洗，能有效抑制金黄色葡萄菌、大肠杆菌和白色念珠菌等致病菌的生长繁殖，消除异味，防治妇科炎症的发生，不易复发，提高生殖器官的生理功能。
具体实施方式
以下实施例中对所有原料的来源并没有特殊的限制，所用的原料均为市售，此外，也可通过本发明提供的制备方法制得。
以下实施例中所使用的白鲜皮提取物和苦参提取物购自西安斯诺特生物技术有限公司，蕲艾购自广州市清平药材市场，其他原料均可从市场购买所得。
实施列1
一种蕲艾抑菌洗液，包括以下重量百分比的组分：蕲艾提取物4％，艾叶挥发油0.1％，白鲜皮提取物0.5％，苦参提取物0.5％，PEG400 6％，三氯生0.05％，水88.85％。
制备方法如下：
(1)准确称取蕲艾叶，置于多功能提取罐中，加10倍水浸泡60min，100℃，回流提取1h，收集艾叶挥发油，水液滤过，滤液放置备用；
(2)收集步骤(1)滤渣，加入8倍水回流提取20min，不低于60℃条件下过滤，收集滤液并与步骤(1)滤液合并，减压浓缩至浓度为0.3g/ml，4-6℃冷藏12h除杂，滤过，滤液备用；
(3)按比例准确称取白鲜皮提取物、苦参提取物，加入到步骤(2)得到的艾叶提取液中，搅匀，滤过；
(4)按比例称取三氯生、艾叶挥发油和PEG400，将三氯生和艾叶挥发油加入到PEG400溶液中分散，搅匀；
(5)将步骤(3)得到的提取液慢慢加入到步骤(4)得到的PEG400混合溶液中，搅匀；
(6)静置，分装，即得蕲艾抑菌洗液。
实施列2
一种蕲艾抑菌洗液，包括以下重量百分比的组分：蕲艾提取物6％，艾叶挥发油0.3％，白鲜皮提取物1％，苦参提取物2％，PEG400 8％，三氯生0.2％，水82.5％。
制备方法如下：
(1)准确称取蕲艾叶，置于多功能提取罐中，加15倍水浸泡40min，95℃，回流提取2h，收集艾叶挥发油，水液滤过，滤液放置备用；
(2)收集步骤(1)滤渣，加入10倍水回流提取40min，不低于60℃条件下过滤，收集滤液并与步骤(1)滤液合并，减压浓缩至浓度为0.285g/ml，4℃冷藏36h除杂，滤过，滤液备用；
(3)按比例准确称取白鲜皮提取物、苦参提取物，加入到步骤(2)得到的艾叶提取液中，搅匀，滤过；
(4)按比例称取三氯生、艾叶挥发油和PEG400，将三氯生和艾叶挥发油加入到PEG400溶液中分散，搅匀；
(5)将步骤(3)得到的提取液慢慢加入到步骤(4)得到的PEG400混合溶液中，搅匀；
(6)静置，分装，即得蕲艾抑菌洗液。
实施列3
一种蕲艾抑菌洗液，包括以下重量百分比的组分：蕲艾提取物8％，艾叶挥发油0.5％，白鲜皮提取物1.5％，苦参提取物3.5％，PEG400 10％，三氯生0.5％，水76％。
制备方法如下：
(1)准确称取蕲艾叶，置于多功能提取罐中，加20倍水浸泡60min，100℃，回流提取3h，收集艾叶挥发油，水液滤过，滤液放置备用；
(2)收集步骤(1)滤渣，加入12倍水回流提取60min，不低于60℃条件下过滤，收集滤液并与步骤(1)滤液合并，减压浓缩至浓度为0.315g/ml，6℃冷藏36h除杂，滤过，滤液备用；
(3)按比例准确称取白鲜皮提取物、苦参提取物，加入到步骤(2)制得的艾叶提取液中，搅匀，滤过；
(4)按比例称取三氯生、艾叶挥发油和PEG400，将三氯生和艾叶挥发油加入到PEG400溶液中分散，搅匀；
(5)将步骤(3)得到的提取液慢慢加入到步骤(4)得到的PEG400混合溶液中，搅匀；
(6)静置，分装，即得蕲艾抑菌洗液。
为了证实本发明蕲艾抑菌洗液的抑菌功效，用按实施例2方法制得的洗液，进行了以下抑菌实验。
1实验方法
抑菌试验操作步骤(参照GB 15979-2002《一次性使用卫生用品卫生标准》)：
1.1实验步骤：
(1)配制LB培养基、营养琼脂培养基、PBS缓冲液和对照液，并进行高压蒸汽灭菌；
(2)在已灭菌的LB培养基中分别接种菌种过夜，活化增菌，培养12小时，接种菌种分别为金黄色葡萄球菌、大肠杆菌和白色念珠菌；
(3)在上述已预培养菌种的LB培养基中取出100μL，加入到5mL PBS缓冲液中，制成菌悬液；
(4)分别取PBS对照液和实施例2制备得到的蕲艾抑菌洗液各4试管，每管5mL，并在各试管中分别滴加100μL上述菌悬液，开始计时，分别作用2min、5min、10min、20min，然后取上述试管中作用后的试样0.5mL分别投入到4.5mL PBS溶液中稀释；
(5)分别取稀释后的各试样0.5mL置于两个平皿中，并用营养琼脂倾注，转动平皿，金黄色葡萄球菌、大肠杆菌和白色念珠菌的试样都在37℃下培养48h，得到最终的检测试样。对最终检测试样作活菌菌落计数，求两个平皿中的活菌菌落数的平均值。
2实验结果
金黄色葡萄球菌、大肠杆菌和白色念珠菌的细菌悬液，在PBS对照液和实施例2制得的蕲艾抑菌洗液作用2min、5min、10min和20min后，活菌菌落情况见表1-3。与对照液相比，按实施例2方法制得的蕲艾抑菌洗液对上3种细菌均有明显的抑制作用。
表1抑菌洗液作用后金黄色葡萄球菌活菌菌落数(单位：cfu)
表2抑菌洗液作用后大肠杆菌活菌菌落数(单位：cfu)
表3抑菌洗液作用后白色念珠菌菌落数(单位：cfu)
3实验结论
由此可见，本发明蕲艾抑菌洗液对金黄色葡萄球菌、大肠杆菌和白色念珠菌等致病菌均有明显的抑制作用，抑菌效果好，且原液稀释5倍后效果更明显，建议使用时用温水稀释原液5倍后再使用。
本发明蕲艾抑菌洗液使用方法为：外用，用前需先摇均匀，可用于阴道冲洗和外阴清洁。①阴道冲洗：取原液适量加温，温开水5倍稀释，直接灌入专用冲洗器，然后插入阴道，挤压瓶体冲洗，每天1-2次。②外阴清洁：取原液适量加温开水5倍稀释，擦洗，冲洗，坐浴或可用本品直接涂抹保洁部位，每日1-3次。
可以理解的是，以上实施方式仅仅是为了说明本发明的原理而采用的示例性实施方式，然而本发明并不局限于此。对于本领域内的普通技术人员而言，在不脱离本发明的精神和实质的情况下，可以做出各种变型和改进，这些变型和改进也视为本发明的保护范围。
Claims (5)
1.一种蕲艾抑菌洗液，其特征在于，包括以下重量百分比的组分：蕲艾叶4-8％，艾叶挥发油0.1-0.5％，白鲜皮提取物0.5-2％，苦参提取物0.5-3.5％，PEG400 6-10％，三氯生0.05-0.5％，水75-85％。
2.根据权利要求1所述的蕲艾抑菌洗液，其特征在于，包括以下重量百分比的组分：蕲艾叶4％，艾叶挥发油0.1％，白鲜皮提取物0.5％，苦参提取物0.5％，PEG400 6％，三氯生0.05％，水88.85％。
3.根据权利要求1所述的蕲艾抑菌洗液，其特征在于，包括以下重量百分比的组分：蕲艾叶6％，艾叶挥发油0.3％，白鲜皮提取物1％，苦参提取物2％，PEG400 8％，三氯生0.2％，水82.5％。
4.根据权利要求1所述的蕲艾抑菌洗液，其特征在于，包括以下重量百分比的组分：蕲艾叶8％，艾叶挥发油0.5％，白鲜皮提取物1.5％，苦参提取物3.5％，PEG400 10％，三氯生0.5％，水76％。
5.根据权利要求1-4任一所述的蕲艾抑菌洗液的制备方法，其特征在于，包括以下步骤：
(1)按比例称取蕲艾叶，置于多功能提取罐中，加入10-20倍的水浸泡20-60min，加热90-100℃、回流提取1-3h，收集艾叶挥发油，水液滤过，滤液放置备用；
(2)收集滤渣，再加8-12倍水回流提取20-60min，温度不低于60℃条件下过滤，收集滤液并与步骤(1)滤液合并，减压浓缩至浓度0.25-0.35g/ml，4-6℃冷藏12-36h除杂，滤过，收集滤液即为艾叶提取液，备用；
(3)按比例称取白鲜皮提取物、苦参提取物，加入到步骤(2)得到的艾叶提取液中，搅匀，滤过；
(4)按比例称取三氯生、艾叶挥发油和PEG400中，并将加入三氯生和艾叶挥发油加入到PEG400溶液中分散，搅匀；
(5)将步骤(3)制得的提取液慢慢加入到步骤(4)得到的PEG400混合溶液中，搅匀，静置，即得蕲艾抑菌洗液。
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111214409A (zh) * | 2020-03-09 | 2020-06-02 | 湖北精耕生物工程有限公司 | 一种免洗消毒液及其制备方法 |
| CN111226989A (zh) * | 2020-03-09 | 2020-06-05 | 湖北精耕生物工程有限公司 | 一种艾叶复合消毒液及其制备方法 |
| CN112206183A (zh) * | 2020-10-11 | 2021-01-12 | 中国医学科学院药用植物研究所 | 免乙醇植物精油消杀湿巾及其制备方法 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102028644A (zh) * | 2009-09-30 | 2011-04-27 | 湖北汇特生物医药技术有限公司 | 基于艾蒿相关提取部位药用特性的洗浴用品 |
| CN103316266A (zh) * | 2013-06-28 | 2013-09-25 | 李时珍医药集团有限公司 | 一种中草药抗菌洗液及其制备工艺 |
| CN106074291A (zh) * | 2016-07-25 | 2016-11-09 | 湖北艾源蕲艾科技有限公司 | 一种蕲艾抑菌洗液 |
| CN106943494A (zh) * | 2017-04-06 | 2017-07-14 | 湖南省健缘医疗科技有限公司 | 洁阴抑菌洗液及其制备方法 |
-
2018
- 2018-07-18 CN CN201810792130.1A patent/CN108904621A/zh active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102028644A (zh) * | 2009-09-30 | 2011-04-27 | 湖北汇特生物医药技术有限公司 | 基于艾蒿相关提取部位药用特性的洗浴用品 |
| CN103316266A (zh) * | 2013-06-28 | 2013-09-25 | 李时珍医药集团有限公司 | 一种中草药抗菌洗液及其制备工艺 |
| CN106074291A (zh) * | 2016-07-25 | 2016-11-09 | 湖北艾源蕲艾科技有限公司 | 一种蕲艾抑菌洗液 |
| CN106943494A (zh) * | 2017-04-06 | 2017-07-14 | 湖南省健缘医疗科技有限公司 | 洁阴抑菌洗液及其制备方法 |
Non-Patent Citations (1)
| Title |
|---|
| 刘巍，等: "艾叶水提液的体外抗菌试验", 《中国药师》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111214409A (zh) * | 2020-03-09 | 2020-06-02 | 湖北精耕生物工程有限公司 | 一种免洗消毒液及其制备方法 |
| CN111226989A (zh) * | 2020-03-09 | 2020-06-05 | 湖北精耕生物工程有限公司 | 一种艾叶复合消毒液及其制备方法 |
| CN112206183A (zh) * | 2020-10-11 | 2021-01-12 | 中国医学科学院药用植物研究所 | 免乙醇植物精油消杀湿巾及其制备方法 |
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Application publication date: 20181130 |