CN108888759A - 一种用于伤口愈合的组合物 - Google Patents
一种用于伤口愈合的组合物 Download PDFInfo
- Publication number
- CN108888759A CN108888759A CN201811108998.1A CN201811108998A CN108888759A CN 108888759 A CN108888759 A CN 108888759A CN 201811108998 A CN201811108998 A CN 201811108998A CN 108888759 A CN108888759 A CN 108888759A
- Authority
- CN
- China
- Prior art keywords
- wound healing
- collagen
- composition
- ciprofloxacin
- chitosan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000029663 wound healing Effects 0.000 title claims abstract description 20
- 239000000203 mixture Substances 0.000 title claims abstract description 15
- 102000008186 Collagen Human genes 0.000 claims abstract description 22
- 108010035532 Collagen Proteins 0.000 claims abstract description 22
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 claims abstract description 22
- 229920001436 collagen Polymers 0.000 claims abstract description 22
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 12
- 241001116389 Aloe Species 0.000 claims abstract description 11
- 229920001661 Chitosan Polymers 0.000 claims abstract description 11
- 235000011399 aloe vera Nutrition 0.000 claims abstract description 11
- 229960003405 ciprofloxacin Drugs 0.000 claims abstract description 11
- 239000003595 mist Substances 0.000 claims abstract description 11
- 229920001184 polypeptide Polymers 0.000 claims abstract description 11
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 11
- 239000009306 yunnan baiyao Substances 0.000 claims abstract description 11
- 108010010803 Gelatin Proteins 0.000 claims abstract description 9
- 239000008273 gelatin Substances 0.000 claims abstract description 9
- 229920000159 gelatin Polymers 0.000 claims abstract description 9
- 235000019322 gelatine Nutrition 0.000 claims abstract description 9
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 9
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 6
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 claims abstract description 6
- 229940116229 borneol Drugs 0.000 claims abstract description 6
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 claims abstract description 6
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 claims abstract description 6
- 230000000694 effects Effects 0.000 abstract description 10
- 231100000241 scar Toxicity 0.000 abstract description 5
- 230000003796 beauty Effects 0.000 abstract description 4
- 239000003814 drug Substances 0.000 abstract description 3
- 229940079593 drug Drugs 0.000 abstract description 3
- 230000001737 promoting effect Effects 0.000 abstract description 2
- 206010052428 Wound Diseases 0.000 description 8
- 208000027418 Wounds and injury Diseases 0.000 description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 239000000499 gel Substances 0.000 description 6
- 238000000034 method Methods 0.000 description 5
- 239000008367 deionised water Substances 0.000 description 4
- 229910021641 deionized water Inorganic materials 0.000 description 4
- 238000003756 stirring Methods 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 2
- 238000010612 desalination reaction Methods 0.000 description 2
- 230000035876 healing Effects 0.000 description 2
- 206010020718 hyperplasia Diseases 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 210000003491 skin Anatomy 0.000 description 2
- 238000013268 sustained release Methods 0.000 description 2
- 239000012730 sustained-release form Substances 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 206010063560 Excessive granulation tissue Diseases 0.000 description 1
- 108050001049 Extracellular proteins Proteins 0.000 description 1
- 101100006584 Mus musculus Clnk gene Proteins 0.000 description 1
- 206010072170 Skin wound Diseases 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000001741 anti-phlogistic effect Effects 0.000 description 1
- 229940030225 antihemorrhagics Drugs 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 102000034240 fibrous proteins Human genes 0.000 description 1
- 108091005899 fibrous proteins Proteins 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 210000001126 granulation tissue Anatomy 0.000 description 1
- 230000000025 haemostatic effect Effects 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000001114 myogenic effect Effects 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 238000007634 remodeling Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Medical Informatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Medicinal Preparation (AREA)
Abstract
本发明公开了一种用于伤口愈合的组合物,属于医药保健品技术领域,涉及伤口愈合。一种用于伤口愈合的组合物,包括下列重量份的各组分:壳聚糖4‑5、芦荟微粉3‑5、胶原蛋白2‑4、明胶8‑10、云南白药4、环丙沙星3、胶原多肽9、冰片3。本发明可以起到促进伤口快速愈合、促进肌肉组织快速生殖的作用,且能达到淡化疤痕、美容的功效。
Description
技术领域
本发明属于医药保健品技术领域,涉及伤口愈合,具体涉及一种促进伤口愈合的组合物。
背景技术
皮肤伤口愈合是指由于遭受外力作用,皮肤组织出现离断或缺损后的愈复过程,包括各种组织的再生和肉芽组织增生、瘢痕组织形成的复杂组合,表现出各种过程的协同作用。最轻度的创伤仅限于皮肤表皮层;稍重者有皮肤和皮下组织断裂,并出现伤口;严重的创伤可有肌肉、肌键、神经的断裂及骨折。
伤口愈合过程为止血、炎症、增殖和重塑。为使伤口成功愈合,四个阶段须顺次完成。现有的伤口愈合药物,各成分之间很难发挥出协同增效的效果,对伤口的治疗效果不佳,存在愈合慢、愈合效果差、且容易发生反复发炎、增生的问题。
为了解决现有技术存在的上述问题,本发明研发了一种可以促使伤口快速愈合的组合物。
发明内容
本发明的目的是提供一种用于伤口愈合的组合物。
本发明是通过以下技术方案实现的:
一种用于伤口愈合的组合物,包括下列重量份的各组分:
壳聚糖4-5 芦荟微粉3-5 胶原蛋白2-4
明胶8-10 云南白药4 环丙沙星3
胶原多肽9 冰片3。
进一步,优选包括下列重量份的各组分:
壳聚糖4 芦荟微粉4 胶原蛋白3
明胶8 云南白药4 环丙沙星3
胶原多肽9 冰片3。
本发明以一定质量比的壳聚糖、芦荟微粉、胶原蛋白、明胶为原料,使用去离子水制备凝胶,作为组合物载体;通过云南白药和环丙沙星协同作用,对伤口进行止血、消炎杀菌,而由于所制备的凝胶具有缓释特性,所以环丙沙星和载体中的芦荟微粉对伤口处有较长时间的消炎作用,杀菌时间长,避免伤口的反复感染,且缓释的胶原蛋白可以进一步加强云南白药的止血功效;组合物中的胶原多肽一种细胞外蛋白质,它是曲3条肽链拧成螺旋形的纤维状蛋白质,胶原多肽是人体内含量最丰富的蛋白质,占全身总蛋白质的30%以上具有促进细胞再生,淡化疤痕的作用,与缓释载体中的壳聚糖共同作用达到生肌的目的,最终冰片与缓释的壳聚糖、芦荟微粉、胶原蛋白一起促进组合物的淡化疤痕、美容的作用。
本发明以具备缓释功效的凝胶为组合物载体,且分别与云南白药、环丙沙星、胶原多肽协调作用,达到快速止血,长效消炎抗菌的作用,并共同起到去腐生肌、淡化疤痕的美容效果。
本发明可以起到促进伤口快速愈合、促进肌肉组织快速生殖的作用,且能达到淡化疤痕、美容的功效。
具体实施方式
下面结合具体实施例对本发明进行进一步的说明,但应该理解,这些实施例仅用于说明本发明而不用于限制本发明的范围。本领域技术人员在本发明上对本发明作出的各种改动或修改,均应同样落于本发明的保护范围之内。
实施例1
准确称取壳聚糖4Kg、芦荟微粉4Kg、胶原蛋白3Kg、明胶8Kg,使用去离子水,按照常规方法制得凝胶,作为组合物载体,然后准确称取云南白药4Kg、环丙沙星3Kg、胶原多肽9 Kg、冰片3 Kg,搅拌均匀,即得用于伤口愈合的组合物。
实施例2
准确称取壳聚糖5Kg、芦荟微粉5Kg、胶原蛋白2Kg、明胶9Kg,使用去离子水,按照常规方法制得凝胶,作为组合物载体,然后准确称取云南白药4Kg、环丙沙星3Kg、胶原多肽9 Kg、冰片3 Kg,搅拌均匀,即得用于伤口愈合的组合物。
实施例3
准确称取壳聚糖4Kg、芦荟微粉3Kg、胶原蛋白4Kg、明胶10Kg,使用去离子水,按照常规方法制得凝胶,作为组合物载体,然后准确称取云南白药4Kg、环丙沙星3Kg、胶原多肽9 Kg、冰片3 Kg,搅拌均匀,即得用于伤口愈合的组合物。
Claims (2)
1.一种用于伤口愈合的组合物,其特征在于,包括下列重量份的各组分:
壳聚糖4-5 芦荟微粉3-5 胶原蛋白2-4
明胶8-10 云南白药4 环丙沙星3
胶原多肽9 冰片3。
2.根据权利要求1所述的一种用于伤口愈合的组合物,其特征在于,包括下列重量份的各组分:
壳聚糖4 芦荟微粉4 胶原蛋白3
明胶8 云南白药4 环丙沙星3
胶原多肽9 冰片3。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201811108998.1A CN108888759A (zh) | 2018-09-21 | 2018-09-21 | 一种用于伤口愈合的组合物 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201811108998.1A CN108888759A (zh) | 2018-09-21 | 2018-09-21 | 一种用于伤口愈合的组合物 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN108888759A true CN108888759A (zh) | 2018-11-27 |
Family
ID=64360070
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201811108998.1A Pending CN108888759A (zh) | 2018-09-21 | 2018-09-21 | 一种用于伤口愈合的组合物 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN108888759A (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109908324A (zh) * | 2019-05-07 | 2019-06-21 | 山西荟缘清农业科技有限公司 | 一种促进伤口快速愈合的芦荟修复凝胶 |
CN110917331A (zh) * | 2019-11-13 | 2020-03-27 | 安徽科门生物科技有限公司 | 一种促进手术后伤口愈合的重要组合物及制备工艺 |
CN111557500A (zh) * | 2020-05-18 | 2020-08-21 | 安徽沃伦科技有限公司 | 一种立体透气可替换滤芯重复使用口罩 |
-
2018
- 2018-09-21 CN CN201811108998.1A patent/CN108888759A/zh active Pending
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109908324A (zh) * | 2019-05-07 | 2019-06-21 | 山西荟缘清农业科技有限公司 | 一种促进伤口快速愈合的芦荟修复凝胶 |
CN110917331A (zh) * | 2019-11-13 | 2020-03-27 | 安徽科门生物科技有限公司 | 一种促进手术后伤口愈合的重要组合物及制备工艺 |
CN111557500A (zh) * | 2020-05-18 | 2020-08-21 | 安徽沃伦科技有限公司 | 一种立体透气可替换滤芯重复使用口罩 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN108888759A (zh) | 一种用于伤口愈合的组合物 | |
CN106581736B (zh) | 原料为娃娃鱼体表黏液的医用粘合剂及制备方法 | |
CN110882412B (zh) | 一种抗菌消炎的医用凝胶及其制备方法 | |
CN111588902A (zh) | 一种大面积创伤急救敷料及其制备方法 | |
CN101862469A (zh) | 一种壳聚糖衍生物快速止血颗粒及其制备方法 | |
CN105536036A (zh) | 一种医用新材料 | |
WO2017030388A1 (ko) | 피부 상처 치료조성물 | |
CN105031708A (zh) | 一种外伤快速止血粉及其制备方法 | |
US10596204B2 (en) | Use of propolis for combating pathological conditions associated with obesity | |
CN101306163A (zh) | 止血生肌散 | |
CN109908324A (zh) | 一种促进伤口快速愈合的芦荟修复凝胶 | |
CN109045350A (zh) | 一种用于伤口愈合的凝胶敷料 | |
CN103223077B (zh) | 一种治疗烧烫伤的中药组合物及其制备方法 | |
CN106267328B (zh) | 一种聚己内酯-胎牛皮胶原纤维复合止血凝胶的制备方法 | |
CN105126154B (zh) | 一种医用生物鼻腔快速止血粉及其制备方法 | |
CN103977266B (zh) | 一种用于止血的铁皮石斛中药组合物 | |
CN107281261B (zh) | 一种易吸收的口腔溃疡贴片及其制备方法 | |
CN102048830A (zh) | 一种具有治疗风湿骨痛功效的药酒 | |
CN109172151A (zh) | 藻酸盐敷料及其使用方法 | |
CN110742921A (zh) | 一种烧伤烫伤药及其制备方法 | |
CN1060673C (zh) | 鼻衄药 | |
CN101468120A (zh) | 一种烧伤膏药及其制备方法 | |
CN101530561A (zh) | 一种止血药 | |
CN103919837A (zh) | 一种具有止血作用的中药 | |
CN115054614A (zh) | 一种根治面部痤疮的净颜膏及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20181127 |