CN108888578A - A kind of preparation method of anti-inflammation hemostasia prevention and treatment plaque toothpaste - Google Patents
A kind of preparation method of anti-inflammation hemostasia prevention and treatment plaque toothpaste Download PDFInfo
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Abstract
The invention belongs to technical field of toothpaste, especially a kind of preparation method of anti-inflammation hemostasia prevention and treatment plaque toothpaste specifically includes following steps：（1）Weigh raw material；（2）By fresh pitaya peel, fresh Hami melon skin and fresh robiniae,flos co-grinding, water is added and stirs evenly, mild fire heating, HIGH PRESSURE TREATMENT, hyperfiltration takes filtrate, obtains extracting solution；（3）Extracting solution is taken off to colourless, galangal rhizome extract, pueraria polysaccharide and momordica grosvenori polysaccharide is added and stirs evenly, mild fire heating, activation medical stone powder, green starch and konjak starch, insulated and stirred, mild fire heating is added, insulated and stirred, cooling treatment obtain anti-inflammation hemostasia prevention and treatment plaque toothpaste；（4）Obtain finished product；So that lotion exquisiteness is smooth, smell is pure and fresh, green high-efficient safety, nonirritant, the phenomenon that effectively eliminating bleeding gums and swelling and aching of gum, clearing heat for detumescence eliminates bad breath, anti-treating dental ulcer, it prevents saprodontia and reduces the generation of plaque, effectively consolidate tooth, guarantee tooth and oral health.
Description
Technical field
The invention belongs to technical field of toothpaste, especially a kind of preparation method of anti-inflammation hemostasia prevention and treatment plaque toothpaste.
Background technique
With the continuous improvement of today's social life level, people's eating habit is also being gradually changed, in addition usually
Bad life habits emerge many oral problems, such as swelling and aching of gum bleeding, the formation of plaque, halitosis and canker sore,
Tooth and oral health to people bring very big adverse effect, and swelling and aching of gum bleeding and plaque are frequent in people's life
The problem not only influences normal life and diet, and also has very big adverse effect to the mental health of people；Therefore,
People oral cavity and dental health can be effectively facilitated by inventing a kind of anti-inflammation hemostasia prevention and treatment plaque toothpaste, guarantee normal life and health
Diet guarantees health so that being in a cheerful frame of mind.
Summary of the invention
In view of the above-mentioned problems, the present invention is intended to provide a kind of preparation method of anti-inflammation hemostasia prevention and treatment plaque toothpaste.
The invention is realized by the following technical scheme：
A kind of preparation method of anti-inflammation hemostasia prevention and treatment plaque toothpaste, specifically includes following steps：
（1）Raw material, 11.3 ~ 12.1 parts of fresh pitaya peel, 9.2 ~ 9.8 parts of fresh Hami melon skin, fresh robiniae,flos are weighed by weight
15.2 ~ 16.4 parts, 1.3 ~ 1.5 parts of medical stone powder of activation, 9 ~ 10 parts of green starch, 7.7 ~ 8.5 parts of konjak starch, galangal extraction
0.22 ~ 0.24 part of object, 0.29 ~ 0.31 part of pueraria polysaccharide, 0.32 ~ 0.34 part of momordica grosvenori polysaccharide；
（2）By fresh pitaya peel, fresh Hami melon skin and fresh robiniae,flos co-grinding, 45 ~ 50 parts by weight are added, temperature is 45 ~ 47
DEG C water stir evenly, mild fire be heated to temperature be 89 ~ 93 DEG C, pressure be 200 ~ 210MPa under conditions of HIGH PRESSURE TREATMENT 5 ~
7min, 10 ~ 12min of HIGH PRESSURE TREATMENT under conditions of pressure is 360 ~ 370MPa, hyperfiltration take filtrate, obtain extracting solution；
（3）Extracting solution is taken off to colourless, galangal rhizome extract, pueraria polysaccharide and momordica grosvenori polysaccharide is added and stirs evenly, mild fire adds
Heat to temperature is 41 ~ 43 DEG C, and activation medical stone powder, green starch and konjak starch is added, and is 380 ~ 400r/min's with revolving speed
Blender 11 ~ 13min of insulated and stirred, it is 77 ~ 79 DEG C that mild fire, which is heated to temperature, is protected with the blender that revolving speed is 200 ~ 220r/min
Temperature stirring 16 ~ 18min, constant temperature 80 ~ 100min of cooling treatment under conditions of temperature is 0.5 ~ 1.5 DEG C, obtain anti-inflammation hemostasia prevention and treatment
Plaque toothpaste；
（4）Vacuum filling sterilizes, and labelling obtains finished product.
As invention further embodiment：The activation medical stone powder, is prepared according to the following steps：By medical stone powder
Broken, constant temperature 9 ~ 11min of frying in the rotary frying pan that merging temperature is 74 ~ 78 DEG C increases temperature to 94 ~ 98 DEG C of continuation constant temperature fryings
15 ~ 17min takes out, and pulverizing to partial size is 5 ~ 10 μm, and it is 0.9 ~ 1.1 times of medical stone weight amount, mass fraction that weight, which is added,
It is mixed evenly for 57% ~ 61% ethanol solution, 6 ~ 8min of magnetization treatment under conditions of magnetic field strength is 420 ~ 430mT,
Suspend 3 ~ 4min, 11 ~ 13min of magnetization treatment under conditions of magnetic field strength is 850 ~ 860mT is 55 ~ 57 DEG C, power in temperature
To obtain activation medical stone powder for microwave drying under conditions of 152 ~ 158W.
As invention further embodiment：The galangal rhizome extract, is prepared according to the following steps：By galangal powder
Broken, 2.3 ~ 2.5 times of galangal weight amounts are added in constant temperature 16 ~ 18min of frying in the rotary frying pan that merging temperature is 60 ~ 62 DEG C
Water continues 28 ~ 32min of mild fire infusion after being boiled by slow fire, take out, and filtering obtains extracting solution one and filter residue；It is heavy that its is added into filter residue
1.7 ~ 1.9 times of amounts of amount, the ethanol solution that mass fraction is 44% ~ 48%, high pressure extraction under conditions of pressure is 270 ~ 280MPa
8 ~ 10min is handled, extracting solution two is obtained；Extracting solution one and extracting solution two are mixed, done by spraying under conditions of temperature is 84 ~ 88 DEG C
It is dry, obtain galangal rhizome extract.
As invention further embodiment：A kind of anti-inflammatory of the preparation method preparation of anti-inflammation hemostasia prevention and treatment plaque toothpaste stops
Plaque toothpaste is controlled in the prevention and cure of schistosomiasis.
Beneficial effects of the present invention：A kind of preparation method of anti-inflammation hemostasia prevention and treatment plaque toothpaste provided by the invention, makes
Lotion exquisiteness is smooth, smell is pure and fresh, and cooperation processing effectively improves biological work so that each material effective component mutually acts synergistically
Property, the level of resources utilization is improved, green high-efficient safety is nonirritant, has stronger anti inflammatory blood quickening to act on, and can effectively facilitate wound
The phenomenon that mouth healing, elimination bleeding gums and swelling and aching of gum, clearing heat for detumescence eliminates bad breath, anti-treating dental ulcer, can thoroughly remove food
Object remains and surface smut, tooth-whitening, nutrition needed for effectively removing oral bacteria growth effectively inhibit the metabolism of bacterium raw
Long and breeding, moreover it is possible to which bulk deposition generates cytotoxicity in the cell membrane of streptococcus mutans, inhibits the growth of bacterium, reduces and becomes
The streptococcic adhesive ability of shape, there is efficient inhibiting effect to pernicious bacteria, it is suppressed that bacterium is reduced in the absorption of dental surface
The corrosion of tooth inhibits the formation of bacterial plaque, prevents saprodontia and reduces the generation of plaque, effectively consolidates tooth, guarantee tooth and
Oral health, so that breath freshening free from extraneous odour.
Specific embodiment
Illustrate the present invention with specific embodiment below, but is not limitation of the present invention.
Embodiment 1
In the embodiment of the present invention, a kind of preparation method of anti-inflammation hemostasia prevention and treatment plaque toothpaste specifically includes following steps：
（1）Raw material, 11.3 parts of fresh pitaya peel, 9.2 parts of fresh Hami melon skin, 15.2 parts of fresh robiniae,flos, activation are weighed by weight
1.3 parts of medical stone powder, 9 parts of green starch, 7.7 parts of konjak starch, 0.22 part of galangal rhizome extract, 0.29 part of pueraria polysaccharide, sieve
0.32 part of Chinese fruit polysaccharide；
（2）By fresh pitaya peel, fresh Hami melon skin and fresh robiniae,flos co-grinding, 45 parts by weight are added, the water that temperature is 45 DEG C
It stirs evenly, it is 89 DEG C that mild fire, which is heated to temperature, and HIGH PRESSURE TREATMENT 5min under conditions of pressure is 200MPa is in pressure
HIGH PRESSURE TREATMENT 10min under conditions of 360MPa, hyperfiltration take filtrate, obtain extracting solution；
（3）Extracting solution is taken off to colourless, galangal rhizome extract, pueraria polysaccharide and momordica grosvenori polysaccharide is added and stirs evenly, mild fire adds
Heat to temperature is 41 DEG C, and activation medical stone powder, green starch and konjak starch is added, and is protected with the blender that revolving speed is 380r/min
Temperature stirring 11min, it is 77 DEG C that mild fire, which is heated to temperature, the blender insulated and stirred 16min for being 200r/min with revolving speed, in temperature
Constant temperature cooling treatment 80min under conditions of being 0.5 DEG C obtains anti-inflammation hemostasia prevention and treatment plaque toothpaste；
（4）Vacuum filling sterilizes, and labelling obtains finished product.
As invention further embodiment：The activation medical stone powder, is prepared according to the following steps：By medical stone powder
Broken, constant temperature frying 9min in the rotary frying pan that merging temperature is 74 DEG C increases temperature to 94 DEG C of continuation constant temperature frying 15min, takes
Out, pulverizing to partial size is 5 μm, and it is that the ethanol solution that 0.9 times of medical stone weight amount, mass fraction are 57% is mixed that weight, which is added,
Conjunction stirs evenly, and magnetization treatment 6min under conditions of magnetic field strength is 420mT suspends 3min, is 850mT's in magnetic field strength
Under the conditions of magnetization treatment 11min, microwave drying under conditions of temperature is 55 DEG C, power is 152 ~ W obtains activation medical stone
Powder.
As invention further embodiment：The galangal rhizome extract, is prepared according to the following steps：By galangal powder
Broken, constant temperature frying 16min in the rotary frying pan that merging temperature is 60 DEG C is added the water of 2.3 times of galangal weight amounts, is boiled by slow fire
Continue mild fire infusion 28min afterwards, take out, filtering obtains extracting solution one and filter residue；1.7 times of its weight amounts, quality are added into filter residue
The ethanol solution that score is 44%, high pressure extraction handles 8min under conditions of pressure is 270MPa, obtains extracting solution two；It will extract
Liquid one and extracting solution two mix, and are spray-dried under conditions of temperature is 84 DEG C, obtain galangal rhizome extract.
As invention further embodiment：A kind of anti-inflammatory of the preparation method preparation of anti-inflammation hemostasia prevention and treatment plaque toothpaste stops
Plaque toothpaste is controlled in the prevention and cure of schistosomiasis.
Embodiment 2
In the embodiment of the present invention, a kind of preparation method of anti-inflammation hemostasia prevention and treatment plaque toothpaste specifically includes following steps：
（1）Raw material, 11.7 parts of fresh pitaya peel, 9.5 parts of fresh Hami melon skin, 15.8 parts of fresh robiniae,flos, activation are weighed by weight
1.4 parts of medical stone powder, 9.5 parts of green starch, 8.1 parts of konjak starch, 0.23 part of galangal rhizome extract, 0.3 part of pueraria polysaccharide, sieve
0.33 part of Chinese fruit polysaccharide；
（2）By fresh pitaya peel, fresh Hami melon skin and fresh robiniae,flos co-grinding, 48 parts by weight are added, the water that temperature is 46 DEG C
It stirs evenly, it is 91 DEG C that mild fire, which is heated to temperature, and HIGH PRESSURE TREATMENT 6min under conditions of pressure is 205MPa is in pressure
HIGH PRESSURE TREATMENT 11min under conditions of 365MPa, hyperfiltration take filtrate, obtain extracting solution；
（3）Extracting solution is taken off to colourless, galangal rhizome extract, pueraria polysaccharide and momordica grosvenori polysaccharide is added and stirs evenly, mild fire adds
Heat to temperature is 42 DEG C, and activation medical stone powder, green starch and konjak starch is added, and is protected with the blender that revolving speed is 390r/min
Temperature stirring 12min, it is 78 DEG C that mild fire, which is heated to temperature, the blender insulated and stirred 17min for being 210r/min with revolving speed, in temperature
Constant temperature cooling treatment 90min under conditions of being 1 DEG C obtains anti-inflammation hemostasia prevention and treatment plaque toothpaste；
（4）Vacuum filling sterilizes, and labelling obtains finished product.
As invention further embodiment：The activation medical stone powder, is prepared according to the following steps：By medical stone powder
Broken, constant temperature frying 10min in the rotary frying pan that merging temperature is 76 DEG C increases temperature to 96 DEG C of continuation constant temperature frying 16min, takes
Out, pulverizing to partial size is 8 μm, and it is the ethanol solution mixing that 1 times of medical stone weight amount, mass fraction are 59% that weight, which is added,
It stirs evenly, magnetization treatment 7min under conditions of magnetic field strength is 425mT suspends 3.5min, is 855mT's in magnetic field strength
Under the conditions of magnetization treatment 12min, microwave drying under conditions of temperature is 56 DEG C, power is 155W obtains activation medical stone powder.
As invention further embodiment：The galangal rhizome extract, is prepared according to the following steps：By galangal powder
Broken, constant temperature frying 17min in the rotary frying pan that merging temperature is 61 DEG C is added the water of 2.4 times of galangal weight amounts, is boiled by slow fire
Continue mild fire infusion 30min afterwards, take out, filtering obtains extracting solution one and filter residue；1.8 times of its weight amounts, quality are added into filter residue
The ethanol solution that score is 46%, high pressure extraction handles 9min under conditions of pressure is 275MPa, obtains extracting solution two；It will extract
Liquid one and extracting solution two mix, and are spray-dried under conditions of temperature is 86 DEG C, obtain galangal rhizome extract.
As invention further embodiment：A kind of anti-inflammatory of the preparation method preparation of anti-inflammation hemostasia prevention and treatment plaque toothpaste stops
Plaque toothpaste is controlled in the prevention and cure of schistosomiasis.
Embodiment 3
In the embodiment of the present invention, a kind of preparation method of anti-inflammation hemostasia prevention and treatment plaque toothpaste specifically includes following steps：
（1）Raw material, 12.1 parts of fresh pitaya peel, 9.8 parts of fresh Hami melon skin, 16.4 parts of fresh robiniae,flos, activation are weighed by weight
1.5 parts of medical stone powder, 10 parts of green starch, 8.5 parts of konjak starch, 0.24 part of galangal rhizome extract, 0.31 part of pueraria polysaccharide, sieve
0.34 part of Chinese fruit polysaccharide；
（2）By fresh pitaya peel, fresh Hami melon skin and fresh robiniae,flos co-grinding, 50 parts by weight are added, the water that temperature is 47 DEG C
It stirs evenly, it is 93 DEG C that mild fire, which is heated to temperature, and HIGH PRESSURE TREATMENT 7min under conditions of pressure is 210MPa is in pressure
HIGH PRESSURE TREATMENT 12min under conditions of 370MPa, hyperfiltration take filtrate, obtain extracting solution；
（3）Extracting solution is taken off to colourless, galangal rhizome extract, pueraria polysaccharide and momordica grosvenori polysaccharide is added and stirs evenly, mild fire adds
Heat to temperature is 43 DEG C, and activation medical stone powder, green starch and konjak starch is added, and is protected with the blender that revolving speed is 400r/min
Temperature stirring 13min, it is 79 DEG C that mild fire, which is heated to temperature, the blender insulated and stirred 18min for being 220r/min with revolving speed, in temperature
Constant temperature cooling treatment 100min under conditions of being 1.5 DEG C obtains anti-inflammation hemostasia prevention and treatment plaque toothpaste；
（4）Vacuum filling sterilizes, and labelling obtains finished product.
As invention further embodiment：The activation medical stone powder, is prepared according to the following steps：By medical stone powder
Broken, constant temperature frying 11min in the rotary frying pan that merging temperature is 78 DEG C increases temperature to 98 DEG C of continuation constant temperature frying 17min, takes
Out, pulverizing to partial size is 10 μm, and it is that the ethanol solution that 1.1 times of medical stone weight amounts, mass fractions are 61% is mixed that weight, which is added,
Conjunction stirs evenly, and magnetization treatment 8min under conditions of magnetic field strength is 430mT suspends 4min, is 860mT's in magnetic field strength
Under the conditions of magnetization treatment 13min, microwave drying under conditions of temperature is 57 DEG C, power is 158W obtains activation medical stone powder.
As invention further embodiment：The galangal rhizome extract, is prepared according to the following steps：By galangal powder
Broken, constant temperature frying 18min in the rotary frying pan that merging temperature is 62 DEG C is added the water of 2.5 times of galangal weight amounts, is boiled by slow fire
Continue mild fire infusion 32min afterwards, take out, filtering obtains extracting solution one and filter residue；1.9 times of its weight amounts, quality are added into filter residue
The ethanol solution that score is 48%, high pressure extraction handles 10min under conditions of pressure is 280MPa, obtains extracting solution two；It will extract
Liquid one and extracting solution two mix, and are spray-dried under conditions of temperature is 88 DEG C, obtain galangal rhizome extract.
As invention further embodiment：A kind of anti-inflammatory of the preparation method preparation of anti-inflammation hemostasia prevention and treatment plaque toothpaste stops
Plaque toothpaste is controlled in the prevention and cure of schistosomiasis.
Comparative example 1
A kind of preparation method of anti-inflammation hemostasia prevention and treatment plaque toothpaste, the difference from embodiment 1 is that, in the preparation process
It is all the same to be added without fresh Hami melon skin, konjak starch and galangal rhizome extract, other conditions.
Comparative example 2
A kind of preparation method of anti-inflammation hemostasia prevention and treatment plaque toothpaste, the difference from embodiment 1 is that, in the preparation process
It is all the same to be added without fresh robiniae,flos, activation medical stone powder and pueraria polysaccharide, other conditions.
Comparative example 3
A kind of preparation method of anti-inflammation hemostasia prevention and treatment plaque toothpaste, the difference from embodiment 1 is that, in the preparation process
It is added without fresh pitaya peel, green starch and momordica grosvenori polysaccharide, other conditions are all the same.
The anti-inflammation hemostasia prevention and treatment plaque experiment effect inspection of the anti-inflammation hemostasia prevention and treatment plaque toothpaste of embodiment and comparative example
It surveys：
1. mouse ear swelling is tested
KM mouse:40, male, 14 ~ 16g is randomly divided into 8 groups by quality, and every group 5,3 groups of embodiment toothpaste groups, 3 groups of comparisons
Example toothpaste group, 1 group of mica filled polypropylene group, 1 group of control group, mouse quarantine 3 ~ 5d mass up to starting to test after 18 ~ 22g, and every group
The left ear of mouse is not processed, and auris dextra two sides applies 50 μ L of dimethylbenzene altogether, and after causing inflammation 1h, control group mouse auris dextra is using at dimethylbenzene
Reason, in addition corresponding toothpaste sample 0.1g is smeared on 7 groups of mouse auris dextra two sides respectively, is taken off neck after 2h and is put to death, cleans sample, is cut double
Ear, punching (the same position of left and right ear) weigh (being accurate to 0.0001g) record, and the of poor quality of same mouse or so ear is swollen
Swollen value；The difference of control group swelling value and toothpaste swelling value and control group swelling value ratio are swelling inhibiting rate, and statistical result is such as
Table 1：
2. rabbit liver hemostasis experiment
New Zealand White Rabbit 40 after the 5d that quarantines is qualified, male, 2.0 ~ 2.5kg is randomly divided into 8 groups, every group 5,3 groups by quality
Embodiment toothpaste group, 3 groups of comparative example toothpaste groups, 1 group of mica filled polypropylene group, 1 group of control group use penta bar of 30g/L after rabbit quarantine
It is slowly injected into than appropriate sodium 30mg/kg through auricular vein, after anaesthetizing successfully, abdomen exposure liver is successively opened, in the identical of every rabbit
Position left lobe of liver lower edge clamp 1cm × 1cm × 3mm surface of a wound, after blood is full of the surface of a wound, control group wound does not apply test sample
Product, in addition 7 groups of wounds point are coated at the entire surface of a wound with 1g correspond to toothpaste, are covered with gauze, are added on gauze with 50g counterweight
Pressure, observe haemostatic effect, every 30s observe wounds streamed blood situation, with filter paper item gently dip in suction until blood no longer ooze out, that is, filter
Until no longer speckling with blood on paper slip, it is bleeding stopping period the time required to record, terminates after determining the haemostatic effect of tested toothpaste product
Experiment, successively closes notch, statistical result such as table 1：
3. preventing and treating plaque clinical trial
Double blind, layering, the parallel clinical research carried out to the adult men and women volunteer of health, makes experiment mesh clear to experimental subjects
, research details, the responsibility for participating in research check it, after being ready that the subject participated in fills in voluntary book according to being included in
With exclusion criteria judgement, screen tested crowd, preliminary screening process includes that oral soft tissue and sclerous tissues check, bacterial plaque inspection with
Whether being selected in for experimental subjects determined, 80 research objects ginseng of improvement plaque index >=1.5 Quigley-Hein is finally selected
Add research, be randomly divided into 8 groups, every group of 10 people, men and women is fifty-fifty, and experimental subjects the range of age is 20 ~ 50 years old, 3 groups of embodiment toothpaste
Group, 3 groups of comparative example toothpaste groups, 1 group of mica filled polypropylene group, 1 group of control group（Blank control group）, changed using Quigley-Hein
Good Turesky plaque index evaluates supragingival plaque, dyes to supragingival plaque and according to following standard recording：0=is without bacterial plaque；1
There is the bacterial plaque being dispersed in in=tooth neck edge；The visible continuous thin bacterial plaque band (reaching lmm wide) in 2=neck edge；3=neck portion bacterium
Articulate fascia is greater than lmm, but is less than the 1/3 of facing；4=bacterial plaque covers the 1/3 ~ 2/3 of facing；5=bacterial plaque covers 2/3 or more facing；
Tooth detection buccal surface and lingual surface are 10 for the numeration of each tooth maximum, except third molar, artificial tooth and the tooth for having neck dummy,
Remaining tooth is in the sum of the column of numeration, mean counting obtained by personal whole tooth detections of each subject's plaque index
(each tooth 2 records) obtains, statistical result such as table 1 divided by total measurement number (teeth number is multiplied by 2)：
The anti-inflammation hemostasia of 1 embodiment and comparative example toothpaste of table prevents and treats plaque experiment effect
As it can be seen from table 1 the anti-inflammation hemostasia prevention and treatment plaque effect of the anti-inflammation hemostasia prevention and treatment plaque toothpaste of the embodiment of the present invention
Fruit is significant, and anti-inflammation hemostasia prevention and treatment plaque effect is substantially better than mica filled polypropylene.
Claims (4)
1. a kind of preparation method of anti-inflammation hemostasia prevention and treatment plaque toothpaste, which is characterized in that specifically include following steps：
（1）Raw material, 11.3 ~ 12.1 parts of fresh pitaya peel, 9.2 ~ 9.8 parts of fresh Hami melon skin, fresh robiniae,flos are weighed by weight
15.2 ~ 16.4 parts, 1.3 ~ 1.5 parts of medical stone powder of activation, 9 ~ 10 parts of green starch, 7.7 ~ 8.5 parts of konjak starch, galangal extraction
0.22 ~ 0.24 part of object, 0.29 ~ 0.31 part of pueraria polysaccharide, 0.32 ~ 0.34 part of momordica grosvenori polysaccharide；
（2）By fresh pitaya peel, fresh Hami melon skin and fresh robiniae,flos co-grinding, 45 ~ 50 parts by weight are added, temperature is 45 ~ 47
DEG C water stir evenly, mild fire be heated to temperature be 89 ~ 93 DEG C, pressure be 200 ~ 210MPa under conditions of HIGH PRESSURE TREATMENT 5 ~
7min, 10 ~ 12min of HIGH PRESSURE TREATMENT under conditions of pressure is 360 ~ 370MPa, hyperfiltration take filtrate, obtain extracting solution；
（3）Extracting solution is taken off to colourless, galangal rhizome extract, pueraria polysaccharide and momordica grosvenori polysaccharide is added and stirs evenly, mild fire adds
Heat to temperature is 41 ~ 43 DEG C, and activation medical stone powder, green starch and konjak starch is added, and is 380 ~ 400r/min's with revolving speed
Blender 11 ~ 13min of insulated and stirred, it is 77 ~ 79 DEG C that mild fire, which is heated to temperature, is protected with the blender that revolving speed is 200 ~ 220r/min
Temperature stirring 16 ~ 18min, constant temperature 80 ~ 100min of cooling treatment under conditions of temperature is 0.5 ~ 1.5 DEG C, obtain anti-inflammation hemostasia prevention and treatment
Plaque toothpaste；
（4）Vacuum filling sterilizes, and labelling obtains finished product.
2. the preparation method of anti-inflammation hemostasia prevention and treatment plaque toothpaste according to claim 1, which is characterized in that the work
Change medical stone powder, is prepared according to the following steps：Medical stone is crushed, constant temperature in the rotary frying pan that merging temperature is 74 ~ 78 DEG C
9 ~ 11min of frying increases temperature to 94 ~ 98 DEG C of continuation constant temperature 15 ~ 17min of frying, takes out, pulverizing to partial size is 5 ~ 10 μ
M is added the ethanol solution that weight is 0.9 ~ 1.1 times of medical stone weight amount, mass fraction is 57% ~ 61% and is mixed evenly,
Magnetic field strength is 6 ~ 8min of magnetization treatment under conditions of 420 ~ 430mT, suspends 3 ~ 4min, is 850 ~ 860mT's in magnetic field strength
Under the conditions of 11 ~ 13min of magnetization treatment, microwave drying under conditions of temperature is 55 ~ 57 DEG C, power is 152 ~ 158W obtains work
Change medical stone powder.
3. the preparation method of anti-inflammation hemostasia prevention and treatment plaque toothpaste according to claim 1, which is characterized in that the height
Rhizoma Alpiniae Officinarum extract is prepared according to the following steps：Galangal is crushed, constant temperature in the rotary frying pan that merging temperature is 60 ~ 62 DEG C
The water of 2.3 ~ 2.5 times of galangal weight amounts is added in 16 ~ 18min of frying, continues 28 ~ 32min of mild fire infusion after being boiled by slow fire, takes
Out, it filters, obtains extracting solution one and filter residue；1.7 ~ 1.9 times of its weight amounts are added into filter residue, the second that mass fraction is 44% ~ 48%
Alcoholic solution, high pressure extraction handles 8 ~ 10min under conditions of pressure is 270 ~ 280MPa, obtains extracting solution two；By one He of extracting solution
Extracting solution two mixes, and is spray-dried under conditions of temperature is 84 ~ 88 DEG C, obtains galangal rhizome extract.
4. the anti-inflammatory of the preparation method preparation of described in any item anti-inflammation hemostasia prevention and treatment plaque toothpaste stops according to claim 1 ~ 3
Plaque toothpaste is controlled in the prevention and cure of schistosomiasis.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101279807A (en) * | 2008-05-22 | 2008-10-08 | 奈曼旗中华麦饭石开发有限公司 | Activating method for medical stone mineral water |
| CN105055205A (en) * | 2015-07-24 | 2015-11-18 | 安徽建筑大学 | Medicinal toothpaste and method for manufacturing same |
| CN105153099A (en) * | 2015-10-17 | 2015-12-16 | 重庆都好生物科技有限公司 | Method for extracting procyanidins (OPC) from pitaya peels |
| CN107362114A (en) * | 2017-08-06 | 2017-11-21 | 何家平 | A kind of sophora flower children's toothpaste |
| CN107823051A (en) * | 2017-11-28 | 2018-03-23 | 李妍 | A kind of preparation method for the toothpaste for preventing and treating pregnant women's oulitis |
-
2018
- 2018-09-18 CN CN201811087353.4A patent/CN108888578A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101279807A (en) * | 2008-05-22 | 2008-10-08 | 奈曼旗中华麦饭石开发有限公司 | Activating method for medical stone mineral water |
| CN105055205A (en) * | 2015-07-24 | 2015-11-18 | 安徽建筑大学 | Medicinal toothpaste and method for manufacturing same |
| CN105153099A (en) * | 2015-10-17 | 2015-12-16 | 重庆都好生物科技有限公司 | Method for extracting procyanidins (OPC) from pitaya peels |
| CN107362114A (en) * | 2017-08-06 | 2017-11-21 | 何家平 | A kind of sophora flower children's toothpaste |
| CN107823051A (en) * | 2017-11-28 | 2018-03-23 | 李妍 | A kind of preparation method for the toothpaste for preventing and treating pregnant women's oulitis |
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Application publication date: 20181127 |