CN1088834A

CN1088834A - " Yiliwan " pill for treating poultry diseases

Info

Publication number: CN1088834A
Application number: CN 93118789
Authority: CN
Inventors: 黎红
Original assignee: Individual
Current assignee: Individual
Priority date: 1993-10-27
Filing date: 1993-10-27
Publication date: 1994-07-06

Abstract

The present invention relates to a kind of " Yiliwan " pill for treating poultry diseases, a ball is the Chinese medicine and western medicine compound preparation, includes Herba Andrographis, Mahonia fortunei (Lindl.) Fedde, Radix Sophorae Flavescentis, Rhizoma Polygoni Cuspidati, Radix Sophorae Tonkinensis, Rhizoma Arisaematis (processed), Fructus Aurantii Immaturus, Herba Taraxaci, Folium et cacumen Breyniae Fruticosae, Herba Adianti Flabellulati, Radix Stephaniae Tetrandrae, Herba Diclipterae Chinensis, Herba Pogostemonis, the Radix Aucklandiae, Herba Ecliptae, lantana, tart fruit rattan, Amaranthusspinosus L., Radix Glycyrrhizae and Realgar, olaquindox, Borneolum Syntheticum.A ball reaches efficient low dosage, and curative effect is fast, cost is low, and treatment hemorrhagic septicemia of fowl effective percentage sick and Hakuri reaches more than 99.4%.

Description

" Yiliwan " pill for treating poultry diseases

The invention belongs to the Chinese medicine and western medicine compound preparation of treatment fowl diseases, a particularly a kind of ball can controlling the hemorrhagic septicemia of fowl disease.

Existing commercially available sulfadimidine (sheet), 920819 batches of lot numbers are 921046 batches of the lot numbers of Guangdong Province Nanhua animal pharmaceutical factory of pharmaceuticals industry company (the 500mg/ sheet) produced and olaquindox, are the production of Guanji, Hubei pharmaceutical factory.Show according to result of the test, not good to the curative effect of chicken Bacillus pasteurii disease.The Chinese herbal and crude drugs preparations (QINJUNLING sheet) of existing commercially available treatment fowl diseases, though certain curative effect is arranged, it is slower to exist effect, taking dose is big, is obvious defects to the treatment acute infectious disease.

The object of the present invention is to provide a kind of Chinese medicine and western medicine compound preparation, reach efficient low dosage, curative effect is fast, and drug effect prolongs, and a ball can be treated hemorrhagic septicemia of fowl and Hakuri.

Technical solution scheme of the present invention is such, prove according to clinical and pharmacological evaluation, Chinese and western drugs rationally and with or composing prescription preparation have the raising curative effect, reduce toxicity, enlarge subject range, shorten the course of treatment, the minimizing dosage.Include Herba Andrographis, Mahonia fortunei (Lindl.) Fedde, Radix Sophorae Flavescentis, Rhizoma Polygoni Cuspidati, Radix Sophorae Tonkinensis, Rhizoma Arisaematis (processed), Fructus Aurantii Immaturus, Herba Taraxaci, Folium et cacumen Breyniae Fruticosae, Herba Adianti Flabellulati, Radix Stephaniae Tetrandrae, Herba Diclipterae Chinensis, Herba Pogostemonis, the Radix Aucklandiae, Herba Ecliptae, lantana, tart fruit rattan, Amaranthusspinosus L., Radix Glycyrrhizae and Realgar, olaquindox, Borneolum Syntheticum in the ball.A ball contains principal agent 0.1 gram to 0.8 gram, reaches efficient low dosage, and curative effect is fast, cost is low, and the effective percentage of treatment hemorrhagic septicemia of fowl and Hakuri reaches more than 99.4%.

The weight portion of above-mentioned various medicines is: Rhizoma Arisaematis (processed) 10-35, Fructus Aurantii Immaturus 10-40, Herba Taraxaci 10-30, Folium et cacumen Breyniae Fruticosae 70-95, Herba Adianti Flabellulati 170-200, Radix Stephaniae Tetrandrae 10-40, Herba Diclipterae Chinensis 60-90, Herba Pogostemonis 50-80, Radix Aucklandiae 10-30, Herba Ecliptae 100-150, lantana 230-280, Herba Andrographis 130-180, tart fruit rattan 180-230, Amaranthusspinosus L. 130-180, big ten contribution 240-280, Radix Glycyrrhizae 15-40, Rhizoma Polygoni Cuspidati 180-230, Radix Sophorae Flavescentis 70-120, Radix Sophorae Tonkinensis 50-90, Realgar 20-40, olaquindox 40-80, Borneolum Syntheticum 5-15.

The preparation method of " Yiliwan " pill for treating poultry diseases of the present invention is such: Rhizoma Arisaematis (processed), Fructus Aurantii Immaturus, Herba Taraxaci, Radix Stephaniae Tetrandrae, Herba Pogostemonis, the Radix Aucklandiae, Herba Ecliptae, Herba Andrographis, the quality standard of the medicines of respectively distinguishing the flavor of such as Mahonia fortunei (Lindl.) Fedde, Radix Glycyrrhizae, Rhizoma Polygoni Cuspidati, Radix Sophorae Flavescentis, Radix Sophorae Tonkinensis, Realgar, olaquindox, Borneolum Syntheticum are according to two ones of " Chinese veterinary drug allusion quotation " 9 years versions.The medical herbs Folium et cacumen Breyniae Fruticosae is that big drying of carrying section's plant Folium et cacumen Breyniae Fruticosae relies branch and leaf in addition, Herba Adianti Flabellulati is the dry Herb of ferrum Pteridiaceae plant flabellum venushair fern, Herba Diclipterae Chinensis is the dry Herb of Verenaceae plant Radix Clerodenri Cyrtophylli, lantana is a Verenaceae, the dry Herb of lantana plant Folium Lantanae Camarae, the tart fruit rattan is the dry Herb of Myrsinacea Embelia plant tart fruit TENGWANG, and Amaranthusspinosus L. is the dry Herb of amaranthaceous plant Amaranthusspinosus L..

Method for making: after Rhizoma Arisaematis (processed), Fructus Aurantii Immaturus, Herba Taraxaci, Folium et cacumen Breyniae Fruticosae, Herba Adianti Flabellulati, Radix Stephaniae Tetrandrae, Herba Diclipterae Chinensis, Herba Pogostemonis, the Radix Aucklandiae, Herba Ecliptae, lantana, Herba Andrographis gone out by the weight weighing of various medicines, use the pulverizer grinding and sieving, olaquindox, the Realgar that adds pulverize stirs and trembles evenly.Other gets Radix Sophorae Tonkinensis, Radix Sophorae Flavescentis, Rhizoma Polygoni Cuspidati, Radix Glycyrrhizae, Mahonia fortunei (Lindl.) Fedde, Amaranthusspinosus L., tart fruit rattan and decocts with water secondary by each weight weighing after good, again the medicinal liquid of secondary is merged 1: 1 concentration of simmer down to, with the general ball base of concentrated medicament, with temperature 50-70 ° oven dry, use the carbon dust coating, make it prolong drug effect, dry with the 50-70 degree.Reuse Borneolum Syntheticum powder and silvery white powder coating, oven dry (50-70 ℃) is used the glazing machines polishing, packed products then.Can make and contain the watered pill that principal agent is all size of 0.1 to 0.8 gram.This product skin is silver gray or white, and interior two layers is black, and the ball heart is Yan Di and Huang Di, two legendary rulers of remote antiquity's color.Have fragrance and sensible abnormal smells from the patient.The above-mentioned technological process of production is according to two ones of " Chinese veterinary drug allusion quotation " 9 years versions and " the pill general rule that 9 years versions of Chinese pharmacopoeia are an one.

Mensuration discrimination method of the present invention is: (1) gets this product, puts microscopically and observes: needle-like calcium oxalate crystal bunchy or be dispersed in is about to 90um, and prism of calcium oxalate is present in the parenchyma in flakes, wood fiber spindle shape, diameter 16-24um, wall are thick slightly, pit transversal crack shape, crosswise or herringbone shape scatter tiny oxalic acid needle in the mesophyll tissue, include the lithocyst of big shape spiral cystolith, diameter is approximately to 36um, be about to 180mm, bigger end has umbilicus sampling point trace, and laminated striation is wavy.

(2) get this product powder 3g, put in the tool plug conical flask, add methanol 10ml merceration 1 hour, filtration is as need testing solution, other gets not cypress alkali reference substance of hydrochloric acid, add methanol and make the solution that every 1ml contains 0.5mg, product solution in contrast is according to thin layer chromatography (" in the Chinese veterinary drug " 9 years two appendix of version 28 pages) test.Drawing test sample and each 5ml of reference substance solution, put respectively on same silica gel g thin-layer plate, is developing solvent with n-butyl alcohol-glacial acetic acid-water (7: 1: 2), launches, takes out, dries, puts under the uviol lamp (365nm) and inspect.In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show an identical yellow fluorescence speckle.

(3) get this product powder 2g, put in the tool plug conical flask, add 50-60 ℃ of lixiviate of methanol solution (6-10) 10 minutes, jolting constantly, filtration, filtrate is as need testing solution; Other gets the olaquindox reference substance, heating methanol solution (6-10) is made the solution that contains 5mg among every 1mmL, solution (above-mentioned two kinds of solution should precedingly temporarily newly be prepared) is according to thin layer chromatography (28 pages of two appendix of " Chinese veterinary drug allusion quotation " 9 years versions) test in contrast, draw above-mentioned two kinds of each 5ml of solution, put respectively on same silica GF254 lamellae, with acetic acid second vinegar-acetone-alcohol-water (50: 40: 10: 5) be developing solvent, after in the dark launching, dry, put under the ultra-violet lamp (254nm) and inspect, in the test sample chromatograph, with the corresponding position of reference substance chromatograph on, be the fluorescence speckle of same color.

Effect of the present invention is such, by Guangxi biological factory Supervisory Office with the clinical trial of " Yiliwan " pill for treating poultry diseases to the chicken pasteurellosis bacillus, according to No. 99 literary composition of the Ministry of Agriculture (1992) farming (herding medicine) word, carry out (seeing Appendix 1) about (three) antimicrobial agents test method and step in enforcement " experiment clinical trial technical specification " (trying) way.Result of the test shows that the herbal function of this compound recipe is heat-clearing and toxic substances removing, stasis removing, purging fire and cooling blood, dissipating blood stasis for subsidence of swelling, the promote qi circulation opening warp that is good for the stomach, and with the mutual together synergism of olaquindox, improves the effect of medicine.Strengthened the ability that suppresses the growth and breeding of pasteurellosis bacillus.The curative effect of " Yiliwan " pill for treating poultry diseases is fast, the cure rate height, and cost is low.Safe and reliable, no side effects.Through Flos pini town, Beliu County, Guangxi plant, with the clinical trial of " Yiliwan " pill for treating poultry diseases treatment white diarrhea disease, the result of the test total effective rate reaches more than 99.4% (sees Appendix 2).

Most preferred embodiment of the present invention, by in the above-mentioned prescription, the weight portion of various medicines is unit with the gram, with Rhizoma Arisaematis (processed) 15, Fructus Aurantii Immaturus 20, Herba Taraxaci 15, Folium et cacumen Breyniae Fruticosae 80, Herba Adianti Flabellulati 180, Radix Stephaniae Tetrandrae oneself 20, after Herba Diclipterae Chinensis 70, Herba Pogostemonis 60, the Radix Aucklandiae 15, Herba Ecliptae 120, lantana 250, Herba Andrographis 150 weigh, use the pulverizer grinding and sieving, olaquindox 50, the Realgar 30 that adds pulverize stirs and trembles evenly, is put into the general ball of general ball pot.Contain principal agent 0.1 gram by every, above-mentioned medicated powder can 10452 on general ball or contain principal agent 0.8 gram can general ball 1306.5, contain principal agent 0.3 gram with every, 3484 the bests of general ball, a ball reaches efficient low dosage, curative effect is fast, cost is low.All reach more than 99.4% with the hemorrhagic septicemia of fowl disease and the Hakuri effective percentage of this " Yiliwan " pill for treating poultry diseases 350 chickens of Flos pini town, Beliu County, Guangxi plant treatment.

Amount ranges of the present invention: per kilogram of body weight restrains with 0.1-5.1, and is safe and reliable, reaches the purpose of preventing and curing diseases.

Claims

1, a kind of " Yiliwan " pill for treating poultry diseases is characterized in that including Herba Andrographis, Mahonia fortunei (Lindl.) Fedde, Radix Sophorae Flavescentis, Rhizoma Polygoni Cuspidati, Radix Sophorae Tonkinensis, Rhizoma Arisaematis (processed), Fructus Aurantii Immaturus, Herba Taraxaci, Folium et cacumen Breyniae Fruticosae, Herba Adianti Flabellulati, Radix Stephaniae Tetrandrae, Herba Diclipterae Chinensis, Herba Pogostemonis, the Radix Aucklandiae, Herba Ecliptae, lantana, tart fruit rattan, Amaranthusspinosus L., Radix Glycyrrhizae and Realgar, olaquindox, Borneolum Syntheticum.

2, " Yiliwan " pill for treating poultry diseases according to claim 1 is characterized in that the weight portion that various medicines contain is: Rhizoma Arisaematis (processed) 10-35, Fructus Aurantii Immaturus 10-40, Herba Taraxaci 10-30, Folium et cacumen Breyniae Fruticosae 70-95, Herba Adianti Flabellulati 170-200, Radix Stephaniae Tetrandrae 10-40, Herba Diclipterae Chinensis 60-90, Herba Pogostemonis 50-80, Radix Aucklandiae 10-30, Herba Ecliptae 100-150, lantana 230-280, Herba Andrographis 130-180, tart fruit rattan 180-230, Amaranthusspinosus L. 130-180, big ten contribution 240-280, Radix Glycyrrhizae 15-40, Rhizoma Polygoni Cuspidati 180-230, Radix Sophorae Flavescentis 70-120, Radix Sophorae Tonkinensis 50-90, Realgar 20-40, olaquindox 40-80, Borneolum Syntheticum 5-15.

3, " Yiliwan " pill for treating poultry diseases according to claim 1 and 2 is characterized in that the weight portion that various medicines contain is: Rhizoma Arisaematis (processed) 15, Fructus Aurantii Immaturus 20, Herba Taraxaci 15, Folium et cacumen Breyniae Fruticosae 80, Herba Adianti Flabellulati 180, Radix Stephaniae Tetrandrae 20, Herba Diclipterae Chinensis 70, Herba Pogostemonis 60, the Radix Aucklandiae 15, Herba Ecliptae 120, lantana 250, Herba Andrographis 150, tart fruit rattan 200, Amaranthusspinosus L. 150, Mahonia fortunei (Lindl.) Fedde 260, Radix Glycyrrhizae 25, Rhizoma Polygoni Cuspidati 200, Radix Sophorae Flavescentis 90, Radix Sophorae Tonkinensis 70, Realgar 30, olaquindox 50, Borneolum Syntheticum 8.

4, " Yiliwan " pill for treating poultry diseases according to claim 1 is characterized in that a ball contains principal agent 0.1-0.8 gram.

5,, it is characterized in that a ball contains principal agent 0.3 gram according to claim 1 or 3 described " Yiliwan " pill for treating poultry diseases.

6, the purposes of the " Yiliwan " pill for treating poultry diseases of claim 1 is used for the treatment of various hemorrhagic septicemia of fowl diseases and Hakuri.