CN108865816A - Gene sequencing reaction cell - Google Patents
Gene sequencing reaction cell Download PDFInfo
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- CN108865816A CN108865816A CN201710317837.2A CN201710317837A CN108865816A CN 108865816 A CN108865816 A CN 108865816A CN 201710317837 A CN201710317837 A CN 201710317837A CN 108865816 A CN108865816 A CN 108865816A
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
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Abstract
The present invention relates to gene sequencing fields, provide a kind of gene sequencing reaction cell, including lid print and load sample piece, are provided with reagent inlet and reagent exit on the lid print；The upper surface of the load sample piece includes peripheral region and central area, and the central area is provided with the first reaction groove of strip, and the peripheral region is trapped among the surrounding of the first reaction groove；The lower surface of the lid print and the peripheral region of the load sample piece fit, and lid print closes the first reaction groove to form reaction channel, and the reagent inlet and reagent exit are connected with reaction channel；The length of the lid print is less than the length of load sample piece, and the width of lid print is less than the width of load sample piece；The heating coating for being heated to reaction channel is coated in the peripheral region of the load sample piece；The beneficial effects of the invention are as follows：The accuracy for improving temperature detection, improves the accuracy of gene sequencing reaction, guarantees being normally carried out for gene sequencing reaction.
Description
Technical field
The present invention relates to gene sequencing technology fields, more particularly, it relates to a kind of gene sequencing reaction cell.
Background technique
Prior art gene sequencing reaction device generally includes gene sequencing reaction cell and temperature control equipment, the temperature
Degree control device has generally comprised heating sheet and conductive rod, and conductive rod and heating sheet are electrically connected, and heating sheet is attached to gene sequencing
Reaction small chamber is heated by reaction channel of the heating sheet to gene sequencing reaction cell.
Such gene sequencing reaction cell, due to the limitation of gene sequencing reaction cell structure, for measuring temperature
The temperature probe of degree can not protrude into reaction channel, and temp probe is generally in contact with heating sheet, by the temperature for detecting heating sheet
Degree, measures the temperature of reaction channel.Gene sequencing reaction cell has certain thickness, and heating sheet is attached to gene sequencing
When being heated on reaction small chamber, heat needs to carry out the reagent in reaction channel through gene sequencing reaction cell
Heating, therefore temp probe temperature detected, with the actual temperature of the reagent in reaction channel there are still biggish error,
It causes the small room temperature measurement of gene sequencing reaction inaccurate, the result of gene sequencing reaction is made deviation occur.
The gene sequencing reaction that error between detection temperature and the actual temperature of reagent can be reduced therefore, it is necessary to one kind is small
The temperature controlled accuracy in gene sequencing reaction cell is improved in room.
Summary of the invention
The purpose of the present invention is to provide a kind of gene sequencing reaction cells, it is intended to it is anti-to solve gene sequencing in the prior art
The temperature of cell is answered to measure inaccurate problem.
In order to realize goal of the invention, a kind of gene sequencing reaction cell is theed improvement is that：A kind of gene sequencing reaction
Cell thes improvement is that：Including lid print and load sample piece, reagent inlet and reagent exit are provided on the lid print；
The upper surface of the load sample piece includes peripheral region and central area, and the central area is provided with the first of strip
Groove is reacted, the peripheral region is trapped among the surrounding of the first reaction groove；The lower surface of the lid print and the load sample piece
Peripheral region fits, and lid print closes the first reaction groove to form reaction channel, and the reagent inlet and reagent go out
Mouth is connected with reaction channel；
The length of the lid print is less than the length of load sample piece, and the width of lid print is less than the width of load sample piece；The load sample piece
Peripheral region on be coated with heating coating for being heated to reaction channel.
In above-mentioned structure, the load sample piece is in cuboid, and the first reaction groove is along load sample leaf length side
To the center that load sample piece upper surface is arranged in；
The both ends of the peripheral region of load sample piece upper surface along its length are respectively arranged with the first electrical pickoff and the second electricity
Contact point, first electrical pickoff and the second electrical pickoff are for realizing the energization for heating coating.
In above-mentioned structure, it is electrically connected on first electrical pickoff and the second electrical pickoff for heating coating
The conductive thimble being powered.
In above-mentioned structure, the lower surface of the lid print is provided with the second reaction groove, the both ends of the second reaction groove
It is connected respectively with the reagent inlet and reagent exit；
When the lower surface of the lid print is fitted in the peripheral region of load sample piece, it is anti-that the second reaction groove is located at first
The surface of groove is answered, and the width of the first reaction groove is greater than the width of the second reaction groove.
In above-mentioned structure, the lid print and load sample piece are in cuboid, and the first reaction groove is along load sample
The center of load sample piece upper surface is arranged in leaf length direction, and the second reaction groove is arranged along lid print length direction
The length of the center of load sample piece lower surface, the second reaction groove reacts the length of groove less than first.
In above-mentioned structure, the both ends of the second reaction groove are also respectively provided with circular-shaped, concave cavity, circular-shaped, concave cavity and institute
The reagent inlet stated is connected with reagent exit, and multiple pillars towards the load sample piece are provided in the circular-shaped, concave cavity.
In above-mentioned structure, the setting of the rounded array of multiple pillars in circular-shaped, concave cavity, adjacent pillar it
Between be reserved with gap for enabling flow through.
From the foregoing, it will be observed that the temperature on the heating coating of gene sequencing reaction cell of the invention can be directly delivered to reaction
In channel, the temperature of reagent and the error of temperature on heating coating are very small in reaction channel, to the temperature on heating coating
When being detected, temperature detected is that can be considered the temperature of reagent in reaction channel, the temperature of reagent in reaction channel
When being adjusted, the accuracy of temperature of reagent adjusting can be significantly improved, improves the accuracy of gene sequencing reaction, guarantees gene
Sequencing reaction is normally carried out.
Detailed description of the invention
Fig. 1 is the schematic perspective view of gene sequencing reaction cell in one embodiment of the invention.
Fig. 2 is the front schematic view of the load sample piece of gene sequencing reaction cell in one embodiment of the invention.
Fig. 3 is the schematic perspective view of the load sample piece of gene sequencing reaction cell in one embodiment of the invention.
Fig. 4 is the assembly structure diagram of gene sequencing reaction cell and pipeline in one embodiment of the invention.
Fig. 5 is the configuration schematic diagram of gene sequencing reaction cell in another embodiment of the present invention.
Fig. 6 is the structural schematic diagram of gene sequencing reaction cell and conductive thimble in another embodiment of the present invention.
Fig. 7 is the structural schematic diagram of one embodiment of the invention middle cover print.
Fig. 8 is the front schematic view of gene sequencing reaction cell in another embodiment of the present invention.
Fig. 9 is diagrammatic cross-section at A-A in Fig. 8.
Figure 10 is the partial enlarged view in Fig. 9 at B.
Figure 11 is the structural schematic diagram of another embodiment of the present invention middle cover print.
Figure 12 is the partial enlarged view in Figure 11 at C.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to the accompanying drawings and embodiments, right
The present invention is further elaborated.
The present invention proposes first embodiment, and the present embodiment proposes a kind of gene sequencing reaction cell, institute as shown in Figure 1, Figure 2
Show, the gene sequencing reaction cell 100 includes lid print 10 and load sample piece 20, wherein is arranged on the lid print 10
There are reagent inlet 101 and reagent exit 102, reagent inlet 101 and reagent exit 102 are the through-hole being arranged on lid print 10；
As shown in Figure 2 and Figure 3, the upper surface of the load sample piece 20 includes peripheral region 205（That is fill part in Fig. 2）The central area and
206（That is part is not filled by Fig. 2）, the position of central area 206 is provided with the first reaction groove 201 of strip, external zones
Domain 205 is trapped among the surrounding of the first reaction groove, and heating coating 202 is coated in the peripheral region of load sample piece 20.The load
The peripheral region 205 of print 20 and the lower surface of lid print 10 fit, and lid print 10 reacts 201 envelope of groove for described first
It closes to form reaction channel, the reagent inlet 101 and reagent exit 102 are connected with the both ends of reaction channel respectively；Such as Fig. 4
Shown, when carrying out gene sequencing reaction, reagent inlet 101 is connected with the pipeline 1010 for being passed through reagent, reagent exit 102 with
The pipeline 1020 of discharge reagent is connected, and reagent enters in reaction channel from reagent inlet 101, is sequenced in reaction channel
Reaction, and be discharged from reagent exit 102.
Further, as shown in Fig. 1, Fig. 5, Fig. 6, the lid print 10 and load sample piece 20 are in cuboid, the lid
The length of print 10 is less than the length of load sample piece 20, and the width of lid print 10 is less than the width of load sample piece 20, the load sample piece 20
Peripheral region on be coated with heating coating 202 for being heated to reaction channel, by leading to heating coating 202
Electricity realizes the heating to gene sequencing reaction cell.In the present embodiment, when lid print 10 is fitted on load sample piece 20, lid sample
Piece 10 is the both ends of the peripheral region 205 of 20 upper surface of load sample piece along its length on the center position of load sample piece 20
The first electrical pickoff 203 and the second electrical pickoff 204 are respectively arranged with, on the first electrical pickoff 203 and the second electrical pickoff 204
It is electrically connected with for the conductive thimble 30 that is powered of heating coating, by the energization to conductive thimble 30, electric current is from adding
It is flowed through on hot coating 202, heating coating 202 then generates heat, and in the present embodiment, which is ITO coating.
By above-mentioned structure, gene sequencing reaction cell of the invention is by the first reaction groove 201 and heats coating 202
It is arranged on load sample piece 20, when needing the temperature to gene sequencing reaction to be adjusted, passes through 203 He of the first electrical pickoff
Second 204 pairs of electrical pickoff heating coating 202 is powered, and the heat that heating coating 202 issues can be directly delivered to first
It reacts in groove 201, the reagent in the first reaction groove 201 is heated.It is adjacent to compared to the prior art by heating sheet
Heating method on sequencing reaction small chamber, the temperature that the present invention heats on coating 202 can be directly delivered in reaction channel,
Therefore the temperature of reagent and the error of temperature on heating coating 202 are very small in reaction channel, to the temperature on heating coating 202
When degree is detected, temperature detected is that can be considered the temperature of reagent in reaction channel, the precision of temperature detection is improved, right
When the temperature of reagent is adjusted in reaction channel, the accuracy of temperature of reagent adjusting can be significantly improved, improves gene sequencing
The accuracy of reaction guarantees being normally carried out for gene sequencing reaction.
The present invention on the basis of the above embodiments, for the lid print 10, as shown in fig. 7, the present invention also proposes
One specific embodiment, the lower surface of the lid print 10 are provided with the second reaction groove 103, and the second reaction groove
103 both ends are connected with the reagent inlet 101 and reagent exit 102 respectively；As shown in Fig. 8, Fig. 9, Figure 10, when described
Lid print 10 when being fitted on load sample piece 20, the second reaction groove 103 be located at the first reaction groove 201 just on
Side, and the width of the first reaction groove 201 is greater than the width of the second reaction groove 103, the first reaction groove 201 and the second reaction
Groove 103 constitutes the reaction channel after merging.If the width phase that the first reaction groove 201 reacts groove 103 with second
Deng, when there is error when lid print 10 or the processing of load sample piece 20, during by lid print 10 and the fitting of load sample piece 20, the
The position of one reaction groove 201 and the second reaction groove 103 is then easy to appear deviation, at this point, due to the upper surface of load sample piece 20
It is coated with heating coating 202, heating coating 202 is then exposed in reaction channel, when being passed through reagent into reaction channel, reagent
Heating coating 202 is then touched, so that the temperature of the reagent contacted with heating coating 202 rises rapidly, the examination in reaction channel
Then there is non-uniform temperature in agent, is in addition also possible to will cause the pollution of reagent.And in this embodiment of the invention, such as
Shown in Figure 10, due to the first reaction groove 201 width much larger than the second reaction groove 103 width, when lid print 10 and/or
When mismachining tolerance occurs in load sample piece 20, when lid print 10 being fitted in load sample piece 20 at this time, pass through the first reaction groove 201 and the
The difference of two reaction 103 width of groove counteracts the mismachining tolerance of lid print 10 and/or load sample piece 20, is coated on load sample piece 20
Heat coating 202 face then lid print 10 lower surface be close to, avoid heating coating 202 be exposed in reaction channel, heating apply
Layer 202 is merely able to be heated with lid print 10 and load sample piece 20, in addition, the first reaction groove 201 increases in the present embodiment
The contact area of reagent and load sample piece 20 enables the heat on load sample piece 20 to be more rapidly transmitted in reagent, improves
The rate of the uniformity and heats conduction that heated to reagent in reaction channel.
For the lid print 10, as shown in Figure 10, Figure 11, the invention also provides a specific embodiment, described
The both ends of two reaction grooves 103 are also respectively provided with circular-shaped, concave cavity 104, circular-shaped, concave cavity 104 and the reagent inlet 101 and examination
Agent outlet 102 is connected, and multiple pillars 105 protruded towards the load sample piece 20, institute are provided in the circular-shaped, concave cavity 104
When stating lid print 10 and being fitted on load sample piece 20, reserved between the bottom surface that pillar 105 reacts groove 201 with the first of load sample piece 20
There are gap or pillar 105 to be resisted against on the bottom surface of the first reaction groove 201 of load sample piece 20.In the present embodiment, multiple convex
The setting of the rounded array of column 105 is reserved in circular-shaped, concave cavity 104, and between adjacent pillar 105 for making reagent flow
The gap crossed.
By above-mentioned such structure, as shown in figure 4, being needed when gene sequencing reaction cell carries out gene sequencing reaction
Pipeline is connected to the reagent inlet 101 of gene sequencing reaction cell and reagent exit 102, the connector of pipeline is pressed on reagent
At entrance 101 and reagent exit 102, the sealing that is easy to implement between lid print 10 and connector.Lid print 10 uses soft material
Material is made, when connector is compressed towards reaction small chamber, bottom surface that groove 201 is reacted with the first of load sample piece 20 due to pillar 105
Between be reserved with gap or pillar 105 is resisted against on the bottom surface of the first reaction groove 201 of load sample piece 20, therefore pillar 105
Supporting role is played, prevents the pressure of connector excessive and so that the bottom surface of circular-shaped, concave cavity 104 is attached to the first of load sample piece 20 and react
On the bottom surface of groove 201, and reaction channel is caused to occlude；Gap, gene sequencing reaction institute are reserved between adjacent pillar 105
The reagent needed then flows into reaction channel from gap.
In the present embodiment, the reagent inlet 101 and reagent exit 102 are cylindrical through-hole, 101 He of reagent inlet
Reagent exit 102 forms the inner wall of arc on lid print 10, which is defined as third arcwall face 1010；The pillar
105 include top surface 1051 and the first arcwall face 1052, wherein the diameter of the first arcwall face 1052 and third arcwall face 1010 is straight
Diameter is equal, and the first arcwall face 1052 coincides with third arcwall face 1010.In addition, the pillar 105 further includes the first side
Face 1053, second side 1054 and the second arcwall face 1055, wherein 1055 place diameter of a circle of the second arcwall face is greater than first
Diameter of a circle where arcwall face, and the center of circle of the first arcwall face 1052 and the center of circle of the second arcwall face 1055 coincide.First side
Face 1053 and second side 1054 are perpendicular with the top surface 1051, the plane and second side where first side 1053
Center line, the center of circle in the center of circle of first arcwall face 1052 and the second arcwall face 1055 are formed after plane intersection where 1054
It is located on the center line.
As shown in figure 12, second reaction, 103 both ends of groove are provided with a convex block 106, which is in cuboid
Shape, the width of the convex block 106 react the width of groove 103 less than second；The convex block 106 has plane 1061 on one, institute
When stating lid print 10 and being fitted on load sample piece 20, the upper plane 1061 is fitted in the first reaction groove 201 of load sample piece 20
Bottom surface on or the upper plane 1061 react groove 201 with the first of load sample piece 20 bottom surface between be reserved with gap.
When connector is compressed towards reaction small chamber, convex block 106 pressure of connector can be prevented excessive and cause the second reaction groove 103 with
The bottom surface contact of first reaction groove 201, causes the obstruction of reaction channel.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Made any modifications, equivalent replacements, and improvements etc., should all be included in the protection scope of the present invention within mind and principle.
Claims (7)
1. a kind of gene sequencing reaction cell, it is characterised in that：Including lid print and load sample piece, examination is provided on the lid print
Agent entrance and reagent exit；
The upper surface of the load sample piece includes peripheral region and central area, and the central area is provided with the first of strip
Groove is reacted, the peripheral region is trapped among the surrounding of the first reaction groove；The lower surface of the lid print and the load sample piece
Peripheral region fits, and lid print closes the first reaction groove to form reaction channel, and the reagent inlet and reagent go out
Mouth is connected with reaction channel；
The length of the lid print is less than the length of load sample piece, and the width of lid print is less than the width of load sample piece；The load sample piece
Peripheral region on be coated with heating coating for being heated to reaction channel.
2. gene sequencing reaction cell according to claim 1, it is characterised in that：The load sample piece is in cuboid,
The center of load sample piece upper surface is arranged in along load sample leaf length direction for the first reaction groove；
The both ends of the peripheral region of load sample piece upper surface along its length are respectively arranged with the first electrical pickoff and the second electricity
Contact point, first electrical pickoff and the second electrical pickoff are for realizing the energization for heating coating.
3. gene sequencing reaction cell according to claim 2, it is characterised in that：First electrical pickoff and the second electricity
The conductive thimble for being powered to heating coating is electrically connected on contact point.
4. gene sequencing reaction cell according to claim 1, it is characterised in that：The lower surface of the lid print is provided with
The both ends of second reaction groove, the second reaction groove are connected with the reagent inlet and reagent exit respectively；
When the lower surface of the lid print is fitted in the peripheral region of load sample piece, it is anti-that the second reaction groove is located at first
The surface of groove is answered, and the width of the first reaction groove is greater than the width of the second reaction groove.
5. gene sequencing reaction cell according to claim 4, it is characterised in that：The lid print and load sample piece be in
Cuboid, the first reaction groove are arranged in the center of load sample piece upper surface along load sample leaf length direction, and described the
The center of load sample piece lower surface, the length of the second reaction groove are arranged in along lid print length direction for two reaction grooves
Less than the length of the first reaction groove.
6. gene sequencing reaction cell according to claim 4, it is characterised in that：The both ends of the second reaction groove are also
It is respectively arranged with circular-shaped, concave cavity, circular-shaped, concave cavity is connected with the reagent inlet and reagent exit, in the circular-shaped, concave cavity
It is provided with multiple pillars towards the load sample piece.
7. gene sequencing reaction cell according to claim 6, it is characterised in that：Multiple pillars setting in a ring
It sets in circular-shaped, concave cavity, the gap for enabling flow through is reserved between adjacent pillar.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710317837.2A CN108865816A (en) | 2017-05-08 | 2017-05-08 | Gene sequencing reaction cell |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710317837.2A CN108865816A (en) | 2017-05-08 | 2017-05-08 | Gene sequencing reaction cell |
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| Publication Number | Publication Date |
|---|---|
| CN108865816A true CN108865816A (en) | 2018-11-23 |
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ID=64287355
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710317837.2A Pending CN108865816A (en) | 2017-05-08 | 2017-05-08 | Gene sequencing reaction cell |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101368206A (en) * | 2008-07-16 | 2009-02-18 | 深圳华因康基因科技有限公司 | Sequencing reaction small chamber, gene sequencing reaction bench and gene sequencing system |
| CN102517196A (en) * | 2011-12-31 | 2012-06-27 | 盛司潼 | Multi-channle sequencing reaction chamber and gene sequencing instrument |
| CN102604826A (en) * | 2012-03-16 | 2012-07-25 | 盛司潼 | Gene sequencing equipment |
| CN103087905A (en) * | 2012-09-14 | 2013-05-08 | 盛司潼 | Sequencing reaction platform and nucleic acid sequence detection device |
| CN105620883A (en) * | 2014-10-31 | 2016-06-01 | 杨新刚 | Flange special for packing bag |
-
2017
- 2017-05-08 CN CN201710317837.2A patent/CN108865816A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101368206A (en) * | 2008-07-16 | 2009-02-18 | 深圳华因康基因科技有限公司 | Sequencing reaction small chamber, gene sequencing reaction bench and gene sequencing system |
| CN102517196A (en) * | 2011-12-31 | 2012-06-27 | 盛司潼 | Multi-channle sequencing reaction chamber and gene sequencing instrument |
| CN102604826A (en) * | 2012-03-16 | 2012-07-25 | 盛司潼 | Gene sequencing equipment |
| CN103087905A (en) * | 2012-09-14 | 2013-05-08 | 盛司潼 | Sequencing reaction platform and nucleic acid sequence detection device |
| CN105620883A (en) * | 2014-10-31 | 2016-06-01 | 杨新刚 | Flange special for packing bag |
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Application publication date: 20181123 |