CN108865819A - Gene sequencing reaction cell - Google Patents
Gene sequencing reaction cell Download PDFInfo
- Publication number
- CN108865819A CN108865819A CN201710318904.2A CN201710318904A CN108865819A CN 108865819 A CN108865819 A CN 108865819A CN 201710318904 A CN201710318904 A CN 201710318904A CN 108865819 A CN108865819 A CN 108865819A
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- China
- Prior art keywords
- load sample
- sample piece
- reaction
- gene sequencing
- reagent
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
Abstract
The present invention relates to gene sequencing fields, provide a kind of gene sequencing reaction cell, including lid print and load sample piece, are provided with reagent inlet and reagent exit on the lid print；The lower surface of the lid print is provided with the second reaction groove, and the lower surface of the lid print is fitted in the load sample on piece, and load sample piece is used for the second reaction groove closing to form reaction channel；The both ends of the second reaction groove are also respectively provided with circular-shaped, concave cavity, and circular-shaped, concave cavity is connected with the reagent inlet and reagent exit respectively, it is provided with multiple pillars towards the load sample piece in the circular-shaped, concave cavity, the gap for enabling flow through is reserved between adjacent pillar；The beneficial effects of the invention are as follows：Pillar plays supporting role, prevents the pressure of connector excessive and the bottom surface of circular-shaped, concave cavity is made to be attached to load sample on piece, and reaction channel is caused to occlude, and ensure that being normally carried out for gene sequencing reaction.
Description
Technical field
The present invention relates to gene sequencing technology fields, more particularly, it relates to a kind of gene sequencing reaction cell.
Background technique
Prior art gene sequencing reaction device generally includes gene sequencing reaction cell and temperature control equipment, and gene is surveyed
Sequence reaction small chamber includes reaction channel, the reagent inlet and reagent exit being connected with reaction channel, logical by reagent inlet
Enter reagent, gene sequencing reaction is carried out in reaction channel, reagent is discharged from reaction outlet.
A kind of gene sequencing reaction cell in the prior art, including upper layer cover plate, intermediate plate and bottom cover plate, intermediate plate position
Between upper layer cover plate and bottom cover plate, the through-hole of strip is provided on interlayer, upper layer cover plate has and long stripes through hole phase
The reagent inlet and reagent exit of connection.The gene sequencing reaction cell of this structure passes through when carrying out gene sequencing reaction
Pipeline is connected with reagent inlet and reagent exit, since the material of upper layer cover plate is glass, reagent inlet and pipeline, examination
Sealing relatively difficult to achieve between agent outlet and pipeline.
When upper layer cover plate is changed to soft material, be able to solve pipeline and reagent inlet and reagent exit seal it is bad
Problem, but when pipeline is pressed on soft upper layer cover plate, if pressure is excessive, it will cause the obstruction of reaction channel, if pressure
Power is too small, and sealing effect is still bad.
Therefore a kind of new gene sequencing reaction cell is needed, reagent inlet and pipeline, reagent exit and pipeline can be made
Between sealing effect more preferably, and do not influence being normally carried out for gene sequencing reaction.
Summary of the invention
The purpose of the present invention is to provide a kind of gene sequencing reaction cells, it is intended to solve in the prior art reagent inlet with
The bad problem of sealing effect between pipeline, reagent exit and pipeline.
In order to realize goal of the invention, a kind of gene sequencing reaction cell is theed improvement is that：Including lid print and load sample
Piece is provided with reagent inlet and reagent exit on the lid print；
The lower surface of the lid print is provided with the second reaction groove, and the lower surface of the lid print is fitted in the load sample piece
On, load sample piece is used for the second reaction groove closing to form reaction channel；
The both ends of the second reaction groove are also respectively provided with circular-shaped, concave cavity, and circular-shaped, concave cavity respectively with the reagent inlet
Be connected with reagent exit, be provided with multiple pillars towards the load sample piece in the circular-shaped, concave cavity, adjacent pillar it
Between be reserved with gap for enabling flow through.
In such a configuration, multiple pillars setting annular in shape is in circular-shaped, concave cavity.
Further, the reagent inlet and reagent exit are cylindrical through-hole, and reagent inlet and reagent exit exist
The inner wall of arc is formed on lid print, which is defined as third arcwall face；
The pillar includes top surface and the first arcwall face, the diameter phase of the diameter and third arcwall face of first arcwall face
Deng, and the first arcwall face is parallel with third arcwall face connects；
When the lower surface of the lid print is fitted in load sample on piece, the top surface of the pillar is the upper surface for being fitted in load sample piece,
Or the pillar top surface and load sample piece upper surface between be reserved with gap.
Further, the pillar further includes the second arcwall face, and diameter of a circle is greater than the first arc where the second arcwall face
Diameter of a circle where shape face, and the center of circle of the first arcwall face is parallel with the center of circle of the second arcwall face connects.
Further, the pillar further includes first side and second side, and first side and second side are and institute
The top surface stated is perpendicular, and first side and second side are perpendicular to the bottom surface of circular-shaped, concave cavity.
In such a configuration, second reaction groove both ends are provided with a convex block, and the width of the convex block is less than the
The width of two reaction grooves.
Further, the convex block has plane on one, described when the lower surface of the lid print is fitted in load sample on piece
Upper plane be fitted in and be reserved between the upper surface or the upper plane and the upper surface of load sample piece of load sample piece between
Gap.
In such a configuration, the upper surface of the load sample piece includes peripheral region and central area, and the center
Domain is provided with the first reaction groove of strip, and the peripheral region is trapped among the surrounding of the first reaction groove；
When the lower surface of the lid print is fitted in the peripheral region of load sample piece, it is anti-that the second reaction groove is located at first
The surface of groove is answered, the width of the first reaction groove is greater than the width of the second reaction groove, while the first reaction groove
Width be greater than the circular-shaped, concave cavity diameter；The pillar is resisted against on the bottom surface of the second reaction groove or pillar and
Gap is reserved between two reaction grooves.
Further, the length of the lid print is less than the length of load sample piece, and the width of lid print is less than the width of load sample piece
Degree；The heating coating for being heated to reaction channel is coated in the peripheral region of the load sample piece.
Further, the load sample piece is in cuboid, and the first reaction groove is set along load sample leaf length direction
Set the center in load sample piece upper surface；
The both ends of the peripheral region of load sample piece upper surface along its length are respectively arranged with the first electrical pickoff and the second electricity
Contact point, first electrical pickoff and the second electrical pickoff are for realizing the energization for heating coating.
From the foregoing, it will be observed that lid print is made of soft material, when connector is compressed towards reaction small chamber, between connector
With good leakproofness, simultaneously because being reserved with gap between pillar and the upper surface of load sample piece or pillar is resisted against load
On the upper surface of print, therefore pillar plays supporting role, prevents the pressure of connector excessive and pastes the bottom surface of circular-shaped, concave cavity
To load sample on piece, and reaction channel is caused to occlude, ensure that being normally carried out for gene sequencing reaction；It is reserved between adjacent pillar
There is gap, reagent needed for gene sequencing reaction then flows into reaction channel from gap.
Detailed description of the invention
Fig. 1 is the schematic perspective view of gene sequencing reaction cell in one embodiment of the invention.
Fig. 2 is the structural schematic diagram of the lid print of gene sequencing reaction cell in one embodiment of the invention.
Fig. 3 is the partial enlarged view in Fig. 2 at C.
Fig. 4 is the assembly structure diagram of gene sequencing reaction cell and pipeline in one embodiment of the invention.
Fig. 5 is the structural schematic diagram of another embodiment of the present invention middle cover print.
Fig. 6 is the partial enlarged view in Fig. 5 at D.
Fig. 7 is the structural schematic diagram of the pillar of gene sequencing reaction cell in another embodiment of the present invention.
Fig. 8 is the front schematic view of the load sample piece of gene sequencing reaction cell in another embodiment of the present invention.
Fig. 9 is the schematic perspective view of the load sample piece of gene sequencing reaction cell in one embodiment of the invention.
Figure 10 is the configuration schematic diagram of gene sequencing reaction cell in another embodiment of the present invention.
Figure 11 is the structural schematic diagram of gene sequencing reaction cell and conductive thimble in another embodiment of the present invention.
Figure 12 is the structural schematic diagram of one embodiment of the invention middle cover print.
Figure 13 is the front schematic view of gene sequencing reaction cell in another embodiment of the present invention.
Figure 14 is diagrammatic cross-section at A-A in Figure 13.
Figure 15 is the partial enlarged view in Figure 14 at B.
Specific embodiment
In order to make the objectives, technical solutions, and advantages of the present invention clearer, with reference to the accompanying drawings and embodiments, right
The present invention is further elaborated.
The present invention proposes first embodiment, and the present embodiment proposes a kind of gene sequencing reaction cell, as shown in Figure 1, Figure 2 and
Shown in Fig. 3, the gene sequencing reaction cell 100 includes lid print 10 and load sample piece 20, wherein on the lid print 10
It is provided with reagent inlet 101 and reagent exit 102, reagent inlet 101 and reagent exit 102 are that leading on lid print 10 is arranged in
Hole；The lower surface of the lid print 10 is provided with the second reaction groove 103, and the both ends difference of the second reaction groove 103
It is connected with the reagent inlet 101 and reagent exit 102.The both ends of the second reaction groove 103 are also respectively provided with
Circular-shaped, concave cavity 104, circular-shaped, concave cavity 104 are connected with the reagent inlet 101 and reagent exit 102, the circular-shaped, concave cavity
Multiple pillars 105 protruded towards the load sample piece 20 are provided in 104, when the lid print 10 is fitted on load sample piece 20,
It is reserved with gap between pillar 105 and the upper surface of load sample piece 20 or pillar 105 is resisted against on the upper surface of load sample piece 20.
In the present embodiment, the setting annular in shape of multiple pillars 105 is reserved in circular-shaped, concave cavity 104, and between adjacent pillar 105
There is the gap for flowing through reagent.
By above-mentioned such structure, as shown in figure 4, being needed when gene sequencing reaction cell carries out gene sequencing reaction
Pipeline is connected to the reagent inlet 101 of gene sequencing reaction cell and reagent exit 102, the connector of pipeline is pressed on reagent
At entrance 101 and reagent exit 102, the sealing that is easy to implement between lid print 10 and connector.Lid print 10 uses soft material
Material is made, connector towards reaction small chamber compress when, between connector have good leakproofness, simultaneously because pillar 105 with
It is reserved with gap between the upper surface of load sample piece 20 or pillar 105 is resisted against on the upper surface of load sample piece 20, therefore pillar
105 play supporting role, prevent the pressure of connector excessive and are attached to the bottom surface of circular-shaped, concave cavity 104 on load sample piece 20, and lead
Reaction channel occlusion is caused, ensure that being normally carried out for gene sequencing reaction；Gap, gene are reserved between adjacent pillar 105
Reagent needed for sequencing reaction then flows into reaction channel from gap.
On the basis of the above embodiments, for the lid print 10, as shown in figure 3, the reagent inlet 101 and examination
Agent outlet 102 is cylindrical through-hole, and reagent inlet 101 and reagent exit 102 form the inner wall of arc on lid print 10,
The inner wall is defined as third arcwall face 1010；The pillar 105 includes top surface 1051 and the first arcwall face 1052, wherein first
The diameter of arcwall face 1052 is equal with the diameter of third arcwall face 1010, and the first arcwall face 1052 and third arcwall face 1010 are flat
Row connects.In addition, the pillar 105 further includes first side 1053, second side 1054 and the second arcwall face 1055,
In 1055 place diameter of a circle of the second arcwall face be greater than diameter of a circle where the first arcwall face, and the center of circle of the first arcwall face 1052
It is parallel with the center of circle of the second arcwall face 1055 to connect.First side 1053 and second side 1054 with 1051 phase of top surface
Vertically, and first side 1053 and second side 1054 perpendicular to circular-shaped, concave cavity 104 bottom surface.In the present embodiment, first side
Plane where 1053 forms center line, the circle of first arcwall face 1052 after intersecting with the plane where second side 1054
The center of circle of the heart and the second arcwall face 1055 is located on the center line.
As shown in figure 3, second reaction, 103 both ends of groove are provided with a convex block 106, which is in cuboid,
Width of the width of the convex block 106 less than the second reaction groove 103；The convex block 106 has plane 1061 on one, the lid
When print 10 is fitted on load sample piece 20, the upper plane 1061 is fitted in the bottom of the first reaction groove 201 of load sample piece 20
Gap is reserved between on face or bottom surface that the upper plane 1061 reacts groove 201 with the first of load sample piece 20.It is connecing
When head is compressed towards reaction small chamber, convex block 106 can prevent the pressure of connector excessive and lead to the second reaction groove 103 and first
The bottom surface contact for reacting groove 201, causes the obstruction of reaction channel.
As shown in Figure 5, Figure 6, for the convex block 106, the invention also provides an embodiment, the convex block 106
Including upper plane 1061 and symmetrical two the 4th arcwall faces 1062, two the 4th arcwall faces 1062 be crossed to form two articles perpendicular to
The straight line of 104 bottom surface of circular-shaped, concave cavity, and the central point of reagent inlet 101 is located in the plane of this two straight lines composition.Reagent
Entrance 101 enters the reagent of reaction channel, and when flowing through convex block 106, such structure of convex block 106 can be avoided the stream to reagent
It is dynamic to impact.
As shown in fig. 7, for the pillar 105, on the basis of the embodiment described in Fig. 2, Fig. 3, the present invention is also proposed
One embodiment, be provided with multiple groups pillar in the circular-shaped, concave cavity, and every group of pillar it is annular in shape circular-shaped, concave cavity is set
On bottom surface, in the present embodiment, 16 pillars 105 are arranged in 104 bottom surface of circular-shaped, concave cavity in total, wherein every 8 are one group, wherein the
The setting annular in shape of one group of pillar 105 in circular-shaped, concave cavity 104, second group of pillar 105 also setting annular in shape in circular-shaped, concave cavity
In 104；In first group of pillar 105, gap is reserved between adjacent pillar 105, second group of pillar 105 and the gap one are a pair of
It should be arranged；When reagent flows in reaction channel from reagent inlet 101, by being staggered for pillar 105, can to reagent into
Row buffering, consequently facilitating the flow velocity to reagent controls.
For the load sample piece, the present invention provides a specific embodiments, as shown in Figure 8, Figure 9, the load sample piece 20
Upper surface include peripheral region 205（That is fill part in Fig. 5）With central area 206（That is part is not filled by Fig. 8）, center
The position in region 206 is provided with the first reaction groove 201 of strip, and peripheral region 205 is trapped among the surrounding of the first reaction groove,
And heating coating 202 is coated in the peripheral region of load sample piece 20.The peripheral region 205 and lid print 10 of the load sample piece 20
Lower surface fit, the described first reaction closing of groove 201 is formed reaction channel, the reagent inlet by lid print 10
101 and reagent exit 102 be connected respectively with the both ends of reaction channel；As shown in figure 4, when carrying out gene sequencing reaction, examination
Agent entrance 101 is connected with the pipeline 1010 for being passed through reagent, and reagent exit 102 is connected with the pipeline 1020 of discharge reagent, tries
Agent enters in reaction channel from reagent inlet 101, and sequencing reaction occurs in reaction channel, and is discharged from reagent exit 102.
Further, as shown in Fig. 1, Figure 10, Figure 11, the lid print 10 and load sample piece 20 are in cuboid, described
The length of lid print 10 is less than the length of load sample piece 20, and the width of lid print 10 is less than the width of load sample piece 20, the load sample piece
The heating coating 202 for being heated to reaction channel is coated in 20 peripheral region, by carrying out to heating coating 202
It is powered, realizes the heating to gene sequencing reaction cell.In the present embodiment, when lid print 10 is fitted on load sample piece 20, lid
Print 10 be positioned at load sample piece 20 center position on, the peripheral region 205 of 20 upper surface of load sample piece along its length two
End is respectively arranged with the first electrical pickoff 203 and the second electrical pickoff 204, is arranged on the load sample piece 20 of gene sequencing reaction cell
There is the conductive thimble 30 contacted with the first electrical pickoff 203 and the second electrical pickoff 204, by the energization to conductive thimble 30,
Electric current is flowed through from heating coating 202, and heating coating 202 then generates heat, and in the present embodiment, which is ITO painting
Layer.
By above-mentioned structure, gene sequencing reaction cell of the invention is by the first reaction groove 201 and heats coating 202
It is arranged on load sample piece 20, when needing the temperature to gene sequencing reaction to be adjusted, passes through 203 He of the first electrical pickoff
Second 204 pairs of electrical pickoff heating coating 202 is powered, and the heat that heating coating 202 issues can be directly delivered to first
It reacts in groove 201, the reagent in the first reaction groove 201 is heated.It is adjacent to compared to the prior art by heating sheet
Heating method on sequencing reaction small chamber, the temperature that the present invention heats on coating 202 can be directly delivered in reaction channel,
Therefore the temperature of reagent and the error of temperature on heating coating 202 are very small in reaction channel, to the temperature on heating coating 202
When degree is detected, temperature detected is that can be considered the temperature of reagent in reaction channel, the precision of temperature detection is improved, right
When the temperature of reagent is adjusted in reaction channel, the accuracy of temperature of reagent adjusting can be significantly improved, improves gene sequencing
The accuracy of reaction guarantees being normally carried out for gene sequencing reaction.
Further, as shown in Figure 12 to Figure 15, when the lid print 10 is fitted on load sample piece 20, described second
Reacting groove 103 is the surface for being located at the first reaction groove 201, and the width of the first reaction groove 201 is greater than the second reaction
The width of groove 103, the first reaction groove 201 and the second reaction groove 103 constitute the reaction channel after merging.If the
One reaction groove 201 is equal with the second reaction width of groove 103, error occurs when lid print 10 or the processing of load sample piece 20
When, during by lid print 10 and the fitting of load sample piece 20, the position of the first reaction groove 201 and the second reaction groove 103
It is then easy to appear deviation, at this point, heating coating 202 is then exposed to since the upper surface of load sample piece 20 is coated with heating coating 202
In reaction channel, when being passed through reagent into reaction channel, reagent then touches heating coating 202, so that with heating coating 202
The temperature of the reagent of contact rises rapidly, and non-uniform temperature then occur in the reagent in reaction channel, is in addition also possible to meeting
Cause the pollution of reagent.
And in this embodiment of the invention, as shown in figure 15, since the width of the first reaction groove 201 is much larger than second
Lid print 10 is fitted in by the width for reacting groove 103 at this time when mismachining tolerance occur in lid print 10 and/or load sample piece 20
When load sample piece 20, by the first reaction groove 201 difference for reacting 103 width of groove with second counteract lid print 10 and/or
The mismachining tolerance of load sample piece 20, the lower surface that the face of heating coating 202 then lid print 10 is coated on load sample piece 20 are close to, are avoided
Heating coating 202 is exposed in reaction channel, and heating coating 202 is merely able to be heated with lid print 10 and load sample piece 20, separately
Outside, in the present embodiment, the first reaction groove 201 increases the contact area of reagent Yu load sample piece 20, so that on load sample piece 20
Heat can be more rapidly transmitted in reagent, improve in reaction channel reagent heat uniformity and heat conduction
Rate.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all in essence of the invention
Made any modifications, equivalent replacements, and improvements etc., should all be included in the protection scope of the present invention within mind and principle.
Claims (10)
1. a kind of gene sequencing reaction cell, it is characterised in that：Including lid print and load sample piece, examination is provided on the lid print
Agent entrance and reagent exit；
The lower surface of the lid print is provided with the second reaction groove, and the lower surface of the lid print is fitted in the load sample piece
On, load sample piece is used for the second reaction groove closing to form reaction channel；
The both ends of the second reaction groove are also respectively provided with circular-shaped, concave cavity, and circular-shaped, concave cavity respectively with the reagent inlet
Be connected with reagent exit, be provided with multiple pillars towards the load sample piece in the circular-shaped, concave cavity, adjacent pillar it
Between have prepsetting gap.
2. gene sequencing reaction cell according to claim 1, it is characterised in that：Multiple pillars are annular in shape to be set
It sets in circular-shaped, concave cavity.
3. gene sequencing reaction cell according to claim 1 or 2, it is characterised in that：The reagent inlet and reagent go out
It mouthful is cylindrical through-hole, reagent inlet and reagent exit form the inner wall of arc on lid print, which is defined as the
Three arcwall faces；
The pillar includes top surface and the first arcwall face, the diameter phase of the diameter and third arcwall face of first arcwall face
Deng, and the first arcwall face is parallel with third arcwall face connects；
When the lower surface of the lid print is fitted in load sample on piece, the top surface of the pillar is the upper surface for being fitted in load sample piece,
Or the pillar top surface and load sample piece upper surface between be reserved with gap.
4. gene sequencing reaction cell according to claim 3, it is characterised in that：The pillar further includes the second arc
Face, diameter of a circle where the second arcwall face are greater than diameter of a circle where the first arcwall face, and the center of circle of the first arcwall face and second
The center of circle of arcwall face connects in parallel.
5. gene sequencing reaction cell according to claim 4, it is characterised in that：The pillar further includes first side
And second side, first side and second side are perpendicular with the top surface, and first side and second side perpendicular to
The bottom surface of circular-shaped, concave cavity.
6. gene sequencing reaction cell according to claim 1, it is characterised in that：Second reaction groove both ends are neighbouring
Circular-shaped, concave cavity is provided with convex block, and the width of the convex block reacts the width of groove less than second.
7. gene sequencing reaction cell according to claim 6, it is characterised in that：The convex block has plane on one, institute
When stating the lower surface of lid print and being fitted in load sample on piece, the upper plane is to be fitted in the upper surface or described of load sample piece
Upper plane and load sample piece upper surface between be reserved with gap.
8. gene sequencing reaction cell according to claim 1, it is characterised in that：The upper surface of the load sample piece includes outer
Enclose region and central area, and the central area is provided with the first reaction groove of strip, the peripheral region is trapped among the
The surrounding of one reaction groove；
When the lower surface of the lid print is fitted in the peripheral region of load sample piece, it is anti-that the second reaction groove is located at first
The surface of groove is answered, the width of the first reaction groove is greater than the width of the second reaction groove, while the first reaction groove
Width be greater than the circular-shaped, concave cavity diameter；The pillar is resisted against on the bottom surface of the second reaction groove or pillar and
Gap is reserved between two reaction grooves.
9. gene sequencing reaction cell according to claim 8, it is characterised in that：The length of the lid print is less than load sample
The length of piece, the width of lid print are less than the width of load sample piece；It is coated in the peripheral region of the load sample piece for reaction
The heating coating that channel is heated.
10. gene sequencing reaction cell according to claim 8, it is characterised in that：The load sample piece is in cuboid,
The center of load sample piece upper surface is arranged in along load sample leaf length direction for the first reaction groove；
The both ends of the peripheral region of load sample piece upper surface along its length are respectively arranged with the first electrical pickoff and the second electricity
Contact point, first electrical pickoff and the second electrical pickoff are for realizing the energization for heating coating.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710318904.2A CN108865819A (en) | 2017-05-08 | 2017-05-08 | Gene sequencing reaction cell |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710318904.2A CN108865819A (en) | 2017-05-08 | 2017-05-08 | Gene sequencing reaction cell |
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| Publication Number | Publication Date |
|---|---|
| CN108865819A true CN108865819A (en) | 2018-11-23 |
Family
ID=64287305
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710318904.2A Pending CN108865819A (en) | 2017-05-08 | 2017-05-08 | Gene sequencing reaction cell |
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| CN1170383A (en) * | 1994-12-13 | 1998-01-14 | 普林斯顿大学理事会 | Multicolor organic light emitting devices |
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