CN108863341A - Titanium alloy-silicate transition zone-hydroxy-apatite halite bioceramic preparation method - Google Patents

Titanium alloy-silicate transition zone-hydroxy-apatite halite bioceramic preparation method Download PDF

Info

Publication number
CN108863341A
CN108863341A CN201810971470.0A CN201810971470A CN108863341A CN 108863341 A CN108863341 A CN 108863341A CN 201810971470 A CN201810971470 A CN 201810971470A CN 108863341 A CN108863341 A CN 108863341A
Authority
CN
China
Prior art keywords
powder
titanium alloy
silicate
apatite
halite
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201810971470.0A
Other languages
Chinese (zh)
Inventor
徐淑波
常诚
王彦鹏
刘凤华
景财年
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shandong Jianzhu University
Original Assignee
Shandong Jianzhu University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shandong Jianzhu University filed Critical Shandong Jianzhu University
Priority to CN201810971470.0A priority Critical patent/CN108863341A/en
Publication of CN108863341A publication Critical patent/CN108863341A/en
Pending legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
    • B22F10/20—Direct sintering or melting
    • B22F10/28—Powder bed fusion, e.g. selective laser melting [SLM] or electron beam melting [EBM]
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/01—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics
    • C04B35/447—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics based on phosphates, e.g. hydroxyapatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/02—Inorganic materials
    • A61L31/022—Metals or alloys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/02—Inorganic materials
    • A61L31/026—Ceramic or ceramic-like structures, e.g. glasses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/02—Inorganic materials
    • A61L31/028—Other inorganic materials not covered by A61L31/022 - A61L31/026
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/146—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • B22F1/0003—
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
    • B22F10/30—Process control
    • B22F10/34—Process control of powder characteristics, e.g. density, oxidation or flowability
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F7/00—Manufacture of composite layers, workpieces, or articles, comprising metallic powder, by sintering the powder, with or without compacting wherein at least one part is obtained by sintering or compression
    • B22F7/002—Manufacture of composite layers, workpieces, or articles, comprising metallic powder, by sintering the powder, with or without compacting wherein at least one part is obtained by sintering or compression of porous nature
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y10/00—Processes of additive manufacturing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y70/00—Materials specially adapted for additive manufacturing
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
    • C04B35/62605—Treating the starting powders individually or as mixtures
    • C04B35/6261—Milling
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/64—Burning or sintering processes
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C14/00—Alloys based on titanium
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22C—ALLOYS
    • C22C32/00—Non-ferrous alloys containing at least 5% by weight but less than 50% by weight of oxides, carbides, borides, nitrides, silicides or other metal compounds, e.g. oxynitrides, sulfides, whether added as such or formed in situ
    • C22C32/001—Non-ferrous alloys containing at least 5% by weight but less than 50% by weight of oxides, carbides, borides, nitrides, silicides or other metal compounds, e.g. oxynitrides, sulfides, whether added as such or formed in situ with only oxides
    • C22C32/0015—Non-ferrous alloys containing at least 5% by weight but less than 50% by weight of oxides, carbides, borides, nitrides, silicides or other metal compounds, e.g. oxynitrides, sulfides, whether added as such or formed in situ with only oxides with only single oxides as main non-metallic constituents
    • C22C32/0031—Matrix based on refractory metals, W, Mo, Nb, Hf, Ta, Zr, Ti, V or alloys thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A61L2300/104—Silver, e.g. silver sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F2999/00—Aspects linked to processes or compositions used in powder metallurgy
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
    • C04B2235/02—Composition of constituents of the starting material or of secondary phases of the final product
    • C04B2235/30—Constituents and secondary phases not being of a fibrous nature
    • C04B2235/32—Metal oxides, mixed metal oxides, or oxide-forming salts thereof, e.g. carbonates, nitrates, (oxy)hydroxides, chlorides
    • C04B2235/3205—Alkaline earth oxides or oxide forming salts thereof, e.g. beryllium oxide
    • C04B2235/3206—Magnesium oxides or oxide-forming salts thereof
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
    • C04B2235/02—Composition of constituents of the starting material or of secondary phases of the final product
    • C04B2235/30—Constituents and secondary phases not being of a fibrous nature
    • C04B2235/32—Metal oxides, mixed metal oxides, or oxide-forming salts thereof, e.g. carbonates, nitrates, (oxy)hydroxides, chlorides
    • C04B2235/3205—Alkaline earth oxides or oxide forming salts thereof, e.g. beryllium oxide
    • C04B2235/3208—Calcium oxide or oxide-forming salts thereof, e.g. lime
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
    • C04B2235/02—Composition of constituents of the starting material or of secondary phases of the final product
    • C04B2235/30—Constituents and secondary phases not being of a fibrous nature
    • C04B2235/32—Metal oxides, mixed metal oxides, or oxide-forming salts thereof, e.g. carbonates, nitrates, (oxy)hydroxides, chlorides
    • C04B2235/3205—Alkaline earth oxides or oxide forming salts thereof, e.g. beryllium oxide
    • C04B2235/3208—Calcium oxide or oxide-forming salts thereof, e.g. lime
    • C04B2235/3212—Calcium phosphates, e.g. hydroxyapatite
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
    • C04B2235/02—Composition of constituents of the starting material or of secondary phases of the final product
    • C04B2235/30—Constituents and secondary phases not being of a fibrous nature
    • C04B2235/32—Metal oxides, mixed metal oxides, or oxide-forming salts thereof, e.g. carbonates, nitrates, (oxy)hydroxides, chlorides
    • C04B2235/3284—Zinc oxides, zincates, cadmium oxides, cadmiates, mercury oxides, mercurates or oxide forming salts thereof
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
    • C04B2235/02—Composition of constituents of the starting material or of secondary phases of the final product
    • C04B2235/30—Constituents and secondary phases not being of a fibrous nature
    • C04B2235/34—Non-metal oxides, non-metal mixed oxides, or salts thereof that form the non-metal oxides upon heating, e.g. carbonates, nitrates, (oxy)hydroxides, chlorides
    • C04B2235/3409—Boron oxide, borates, boric acids, or oxide forming salts thereof, e.g. borax
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
    • C04B2235/02—Composition of constituents of the starting material or of secondary phases of the final product
    • C04B2235/30—Constituents and secondary phases not being of a fibrous nature
    • C04B2235/34—Non-metal oxides, non-metal mixed oxides, or salts thereof that form the non-metal oxides upon heating, e.g. carbonates, nitrates, (oxy)hydroxides, chlorides
    • C04B2235/3418—Silicon oxide, silicic acids, or oxide forming salts thereof, e.g. silica sol, fused silica, silica fume, cristobalite, quartz or flint
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
    • C04B2235/02—Composition of constituents of the starting material or of secondary phases of the final product
    • C04B2235/50—Constituents or additives of the starting mixture chosen for their shape or used because of their shape or their physical appearance
    • C04B2235/54—Particle size related information
    • C04B2235/5418—Particle size related information expressed by the size of the particles or aggregates thereof
    • C04B2235/5427—Particle size related information expressed by the size of the particles or aggregates thereof millimeter or submillimeter sized, i.e. larger than 0,1 mm
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
    • C04B2235/02—Composition of constituents of the starting material or of secondary phases of the final product
    • C04B2235/50—Constituents or additives of the starting mixture chosen for their shape or used because of their shape or their physical appearance
    • C04B2235/54—Particle size related information
    • C04B2235/5418—Particle size related information expressed by the size of the particles or aggregates thereof
    • C04B2235/5436—Particle size related information expressed by the size of the particles or aggregates thereof micrometer sized, i.e. from 1 to 100 micron
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
    • C04B2235/65—Aspects relating to heat treatments of ceramic bodies such as green ceramics or pre-sintered ceramics, e.g. burning, sintering or melting processes
    • C04B2235/66—Specific sintering techniques, e.g. centrifugal sintering
    • C04B2235/665—Local sintering, e.g. laser sintering
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
    • C04B2235/70—Aspects relating to sintered or melt-casted ceramic products
    • C04B2235/74—Physical characteristics
    • C04B2235/75—Products with a concentration gradient
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P10/00—Technologies related to metal processing
    • Y02P10/25—Process efficiency

Landscapes

  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Manufacturing & Machinery (AREA)
  • Materials Engineering (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Ceramic Engineering (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Mechanical Engineering (AREA)
  • Physics & Mathematics (AREA)
  • Automation & Control Theory (AREA)
  • Plasma & Fusion (AREA)
  • Structural Engineering (AREA)
  • Metallurgy (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Composite Materials (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The invention belongs to biomedical materials field, especially titanium alloy-silicate transition zone-hydroxy-apatite halite bioceramic porous materials.By titanium alloy substrate material powder, titanium alloy-silicate-hydroxy-apatite halite transition zone powder and hydroxyapatite salt powder composition, powder is all made of plus dehydrated alcohol method that mechanization ball milling is carried out in ball mill refines powder grain, by after configured each powder cold compaction 10‑6Degasification is gradually heated under de- vacuum condition, 3D printing model is constructed by CAD according to the characteristics of implantation material, CAD model is layered by computer, obtain each layer of model of cross section information, according to the design feature of implantation material section, dynamic regulation lays titanium alloy substrate material powder from inside to outside, titanium alloy-silicate transition zone-hydroxy-apatite halite transition zone powder and hydroxyapatite salt powder, powder is loaded according to the more gradients of the streamline of implantation material from bottom to top, then at 500-600 DEG C, 50-200Mpa argon atmosphere protects lower selective laser to melt 3D printing, it prepares using titanium alloy-hydroxy-apatite halite as the titanium alloy of matrix-silicate transition zone-hydroxy-apatite halite bioceramic porous material.Material of the present invention is significantly improved compared with traditional handicraft toughness, wearability, intensity after tested.

Description

Titanium alloy-silicate transition zone-hydroxy-apatite halite bioceramic preparation method
Technical field
The invention belongs to biomedical materials field, especially titanium alloy-silicate transition zone-hydroxy-apatite halite biologies Ceramic porous material.
Background technique
Currently, the bio-medical material of clinical application, such as skeleton implant, cardiac stent mostly use titanium alloy, titanium is closed Fitting has good biocompatibility, corrosion resistance and mechanical property, therefore titanium alloy is very widely used, cures in clinic Educational circles gets the nod.Metal bone existing for titanium alloy etc. is implanted into material, and there is the mechanical compatibility differences with biological bone Problem.5.3 times higher than natural bone of the tensile strength of titanium alloy etc materials or more, elasticity modulus is even more high 11 times or more.Titanium closes The skeleton implants such as gold generate very big " stress shielding " effect to body local bone tissue, can induce blocking property bone loss. Lead to original biological bone fragility of skeleton implantation material and surrounding, the area of new bone undergrowth around skeleton implantation material And stress concentrates initiation inflammation between skeleton implantation material and biological bone.Develop novel mechanics and biocompatibility more Ideal bio-medical material is very necessary.Meanwhile skeleton implantation material operation take out, increase medical person pain, Time and expense, therefore, the high medical material that is tough and can degrading in vivo of research and development is current medical field One of important directions of development.And hydroxyapatite is the main constituents of vertebrate skeletal and tooth, is had good Bioactivity and biocompatibility.Relative to traditional metal（Stainless steel, titanium alloy）And ceramics（Aluminium oxide, silicon nitride）Class bone Before alternative materials, not only corrosion resistance is strong for hydroxyapatite, self-bone grafting generative nature is strong, but also its degradation in vivo also eliminates The security risk of person.Hydroxyapatite coating layer refers to using titanium alloy as substrate, using physical chemistry means by hydroxyapatite coat Cover the hard tissue implanting material being prepared on its surface.After the material is implanted into human body, titanium alloy can provide enough mechanical strengths, The hydroxyapatite coating layer on surface be easy to human body synosteosis, induce the generation of new bone, general several months in human body bone surface Induce the generation of new bone.But the disadvantage that current technology is not strong enough there are still binding force, so that occurring after being implanted into vivo The phenomenon that coating shedding.
Based on above-mentioned purpose, it is more that the present invention develops a kind of titanium alloy-silicate transition zone-hydroxy-apatite halite bioceramic Porous materials use more gradient proportion mixed-powders for raw material, use metal three-dimensional printer printing bone implant etc..Of the invention Titanium alloy-silicate transition zone-hydroxy-apatite halite bioceramic porous material main chemical compositions Si, O, P, H, Ca, Remaining is Ti.The existing titanium alloy material in China is in patent 104710188A at present, through research, analysis shows having as Zn, Mg Equal elements addition, but service performance raising is limited.Therefore, titanium alloy-is generated by more gradient 3 D-printings in the present invention Silicate transition zone-hydroxy-apatite halite bioceramic porous material purpose.
Summary of the invention
The purpose of the invention patent is：It is to overcome the above-mentioned prior art insufficient, a kind of stable processing technology, production is provided Low in cost, non-pollution discharge, titanium alloy-silicate transition zone-hydroxy-apatite halite that production can be organized under normal conditions Bioceramic porous material, the biomedical materials such as more traditional stainless steel, titanium alloy have better biocompatibility, more often The toughness for advising ceramic biomedical material is substantially improved.
Scheme material requested presses following specific preparation step：
（1）The preparation of titanium alloy substrate powder：
The preparation process of titanium alloy substrate powder is：Titanium alloy substrate dusty material chemical component is：Titanium, silver, magnesium, vanadium, nickel and Copper is constituent element, and composition can be indicated with aTi-bAg-cMg-dV-eNi-fCu, wherein a：83-90, b：1-3, c：3-5, d：5-8, e：1-2, f：1-2 and a+b+c+d+e+f=100.Add dehydrated alcohol in ball milling the titanium alloy substrate composite powder prepared in proportion It is carried out mechanization ball milling 24 hours in machine, obtaining has 50-150 μm of crystallite dimension superfines, and powder is packed into crystal vessel In, under the conditions of argon atmosphere protection and 1300 DEG C -1600 DEG C of temperature, keep the temperature 90min-180min.
The present invention is to obtain optimal comprehensive mechanical property and biological antiseptic corrosion energy, the content of strict control impurity：Ti Degree of purity be more than or equal to 99.99%；The degree of purity of Mg is more than or equal to 99.999%, and tramp element total amount is not more than 0.3%.
（2）The preparation of silicate bioceramic material powder：
The chemical component and weight percent CaO of silicate bioceramic material：42-50%, SiO2：48-52%, B2O3：0.3- 2.4%, ZnO：0.2-3.0%, MgO：0.8-4.5%.The silicate bioceramic material powder prepared in proportion is added into dehydrated alcohol It is carried out mechanization ball milling 24 hours in ball mill, obtaining has 50-150 μm of crystallite dimension superfines.
（3）The preparation of hydroxyapatite salt powder：
The chemical component of hydroxyapatite salt powder：6 (OH) 2 of Ca10 (PO4) will add dehydrated alcohol by hydroxyapatite salt powder It is carried out mechanization ball milling 24 hours in ball mill, obtaining has 50-150 μm of crystallite dimension superfines.
（4）Titanium alloy-silicate-hydroxy-apatite halite transition zone powder preparation：
Configuration forms titanium alloy-silicate-hydroxy-apatite halite transition zone of more gradients from the inside to the outside, is always divided into 5 layers, most Internal layer to outermost powder weight ratio is respectively：
First layer：Titanium alloy substrate powder：Silicate biomaterial powder=81.6：18.4
The second layer：Titanium alloy substrate powder：Silicate biomaterial powder=72.4：27.6
Third layer：Titanium alloy substrate powder：Silicate biomaterial powder=54：46
4th layer：Hydroxyapatite salt powder：Silicate biomaterial powder=72.4：27.6
Layer 5：Hydroxyapatite salt powder：Silicate biomaterial powder=81.6：18.4
It prepares titanium alloy-silicate-hydroxy-apatite halite transition zone powder respectively according to weight ratio, adds dehydrated alcohol in ball It is carried out mechanization ball milling 24 hours in grinding machine, obtaining has 50-150 μm of crystallite dimension superfines.
The effect difference of basic asphalt mixture element is as follows in the present invention：
Zn is the element having a major impact to cell development, is the necessary micronutrient element of human body, the addition of Zn can The intensity of alloy is improved, while effectively facilitating the generation of the non-basal slip of titanium alloy at room temperature, improves the plastic processing of titanium alloy Ability.
Ni is good with titanium associativity, and elevated temperature strength is good, hardness is high, density is big, resistance to corrosion is strong, thermal expansion coefficient is small, can Further increase obdurability, the corrosion resistance of alloy.
V has the title of metal " vitamin ".By refining the tissue and crystal grain of titanium, grain coarsening temperature is improved, to play Increase the intensity, toughness and wearability of titanium alloy.Vanadium is the essential trace elements of the human body, vanadium and bone and tooth normal development and calcium Change related, tooth can be enhanced, normal bone growth and development is promoted to the resistance of dental caries tooth.
Ag, Cu are antiseptic elements, the anti-microbial property after improving material implantation.
The present invention provides more gradient 3 D-printings to generate titanium alloy-silicate transition zone-hydroxy-apatite halite biology pottery Porcelain porous material, it is characterised in that：The material is from inside to outside by the titanium alloy of more gradients-hydroxyapatite salt matrix material group At crystal grain diameter 200-800nm.
The present invention is by the following technical programs：Titanium alloy-silicate transition zone-hydroxy-apatite halite bioceramic is porous Material powder is by titanium alloy substrate material powder, titanium alloy-silicate-hydroxy-apatite halite transition zone powder and hydroxy-apatite Halite powder constituent, powder is all made of the method for adding dehydrated alcohol to carry out mechanization ball milling in ball mill, and powder grain is thin Change, will gradually heat degasification in the case where 10-6 takes off vacuum condition after configured each powder cold compaction, leads to according to the characteristics of implantation material CAD building 3D printing model is crossed, CAD model is layered by computer, each layer of model of cross section information is obtained, according to implantation Dynamic regulation lays titanium alloy substrate material powder, titanium alloy-silicate transition zone-hydroxyl to the design feature of object section from inside to outside Base apatite salt transition zone powder and hydroxyapatite salt powder load powder according to the more gradients of the streamline of implantation material from bottom to top End, then at 500-600 DEG C, 50-200Mpa argon atmosphere protects lower selective laser to melt 3D printing, prepares with titanium alloy- Hydroxy-apatite halite is titanium alloy-silicate transition zone-hydroxy-apatite halite bioceramic porous material of matrix.
More gradient 3 D-printings generate titanium alloy-silicate transition zone-hydroxy-apatite halite bioceramic porous material It without equipment such as vacuum melting furnace, high temperature and pressure, can organize to produce using common metal 3D printing equipment, the present invention Small investment, quick, can quickly recoup capital outlay cost.
Compared with existing casting medical titanium alloy, hydroxy-apatite halite and bioceramic technology, more gradient 3 D-printings are raw It is had the following advantages that at titanium alloy-silicate transition zone-hydroxy-apatite halite bioceramic porous material preparation method：
（1）Toughness, wearability, intensity significantly improve, and are spaced the poor mechanical property of 2 hours samples less than 6%, this is beneficial to greatly In batches, the steady production of small size medical material.It is tiny to enhance particle size, is evenly distributed, structure stability is high, closes in titanium Auri body is well combined.Toughness, hardness and the wear-resisting property of material significantly improve, and are particularly suitable for skeleton implantation material The application of equal medical materials applies also for requiring high-intensitive and high-wearing feature components.
（2）Microstructure stability is good, will not decompose toxic gas or toxic dissolved matter, have to the health of customer Place, corrosion resistance, antibiotic property, biocompatibility are good.
（3）The present invention is because of selective melting 3 D-printing, and the technology stability of production is high, low production cost, pollution-free row It puts, can organize to produce under normal conditions, the equipment such as vacuum melting furnace, high temperature and pressure.
Detailed description of the invention
Here is that specific embodiments of the present invention are described in detail in conjunction with the accompanying drawings and embodiments.
Fig. 1 is titanium alloy-silicate-hydroxy-apatite halite buffer layer material schematic diagram；
It can be seen that titanium alloy-silicon from titanium alloy-silicate shown in FIG. 1-hydroxy-apatite halite buffer layer material schematic diagram The configuration of hydrochlorate-hydroxy-apatite halite transition zone, forms titanium alloy-silicate-hydroxyapatite of more gradients from the inside to the outside Salt transition zone is always divided into 5 layers.
Specific embodiment
Highly preferred embodiment of the present invention is given below：Titanium, silver, magnesium, vanadium, nickel and copper are constituent element, and composition can use aTi- BAg-cMg-dV-eNi-fCu indicates, wherein a：83-90, b：1-3, c：3-5, d：5-8, e：1-2, f：1-2 and a+b+c+d+e+f =100.Dehydrated alcohol is added to carry out mechanization ball milling 24 in ball mill the titanium alloy substrate composite powder prepared in proportion small When, obtaining has 50-150 μm of crystallite dimension superfines, powder is fitted into crystal vessel, in argon atmosphere protection and 1300 Under the conditions of DEG C -1600 DEG C of temperature, 90min-180min is kept the temperature.By silicate transition zone bioceramic material according to weight percent Than for CaO：42-50%, SiO2：48-52%, B2O3：0.3-2.4%, ZnO：0.2-3.0%, MgO：0.8-4.5%.It will match in proportion The silicate bioceramic material powder of system adds dehydrated alcohol to carry out in ball mill mechanization ball milling 24 hours, is had 50-150 μm of crystallite dimension superfines.By hydroxyapatite salt powder Ca10 (PO4) 6 (OH) 2 plus dehydrated alcohol in ball mill Middle progress mechanization ball milling 24 hours, obtaining has 50-150 μm of crystallite dimension superfines.According to powder weight proportional arrangement By titanium alloy-silicate-hydroxy-apatite halite transition zone powder of internal layer to outer more gradients, 5 layers are always divided into, innermost layer is extremely Outermost powder weight ratio is respectively：
First layer：Titanium alloy substrate powder：Silicate biomaterial powder=81.6：18.4
The second layer：Titanium alloy substrate powder：Silicate biomaterial powder=72.4：27.6
Third layer：Titanium alloy substrate powder：Silicate biomaterial powder=54：46
4th layer：Hydroxyapatite salt powder：Silicate biomaterial powder=72.4：27.6
Layer 5：Hydroxyapatite salt powder：Silicate biomaterial powder=81.6：18.4
It prepares titanium alloy-silicate-hydroxy-apatite halite transition zone powder respectively according to weight ratio, adds dehydrated alcohol in ball It is carried out mechanization ball milling 24 hours in grinding machine, obtaining has 50-150 μm of crystallite dimension superfines.By configured each powder Degasification is gradually heated in the case where 10-6 takes off vacuum condition after cold compaction, 3D printing model is constructed by CAD according to the characteristics of implantation material, CAD model is layered by computer, each layer of model of cross section information is obtained, according to the design feature of implantation material section by interior And outer dynamic regulation lays titanium alloy substrate material powder, titanium alloy-silicate transition zone-hydroxy-apatite halite transition zone powder With hydroxyapatite salt powder, powder are loaded according to the more gradients of the streamline of implantation material from bottom to top, then at 500-600 DEG C, 50- 200Mpa argon atmosphere protects lower selective laser to melt 3D printing, prepares using titanium alloy-hydroxy-apatite halite as the titanium of matrix Alloy-silicate transition zone-hydroxy-apatite halite bioceramic porous material.Then T6 processing is carried out, and is tested for the property. Can get high-intensitive medium plasticity titanium alloy-hydroxy-apatite halite bioceramic porous material under the technique, (tensile strength is 411MPa, yield strength 370MPa, elongation percentage 6.3%).Corrosion rate under simulated body fluid environment is 0.27mm/ year.The requirement of orthopaedics inner implantation material bone plate, bone nail etc. can be met.

Claims (1)

1. titanium alloy-silicate transition zone-hydroxy-apatite halite bioceramic preparation method it is characterized in that：The material by interior and It is made of outside the titanium alloy of more gradients-hydroxyapatite salt matrix material, crystal grain diameter 200-800nm, by titanium alloy substrate Material powder, titanium alloy-silicate-hydroxy-apatite halite transition zone powder and hydroxyapatite salt powder composition, powder are equal Powder grain is refined using the method for adding dehydrated alcohol to carry out mechanization ball milling in ball mill, configured each powder is cold 10 after compacting-6Degasification is gradually heated under de- vacuum condition, 3D printing model is constructed by CAD according to the characteristics of implantation material, is led to Cross computer to be layered CAD model, obtain each layer of model of cross section information, according to the design feature of implantation material section by interior and Outer dynamic regulation lay titanium alloy substrate material powder, titanium alloy-silicate transition zone-hydroxy-apatite halite transition zone powder and Hydroxyapatite salt powder loads powder according to the more gradients of the streamline of implantation material from bottom to top, then at 500-600 DEG C, 50- 200Mpa argon atmosphere protects lower selective laser to melt 3D printing, prepares using titanium alloy-hydroxy-apatite halite as the titanium of matrix Alloy-silicate transition zone-hydroxy-apatite halite bioceramic porous material, specific preparation process are as follows：
（a）The preparation process of titanium alloy substrate powder is：Titanium alloy substrate dusty material chemical component is：Titanium, silver, magnesium, vanadium, nickel It is constituent element with copper, composition can be indicated with aTi-bAg-cMg-dV-eNi-fCu, wherein a：83-90, b：1-3, c：3-5, d：5- 8, e：1-2, f：1-2 and a+b+c+d+e+f=100；Add dehydrated alcohol in ball the titanium alloy substrate composite powder prepared in proportion It is carried out mechanization ball milling 24 hours in grinding machine, obtaining has 50-150 μm of crystallite dimension superfines, and powder is packed into graphite and is held In device, under the conditions of argon atmosphere protection and 1300 DEG C -1600 DEG C of temperature, 90min-180min is kept the temperature；
（b）The preparation of silicate bioceramic material powder：The chemical component and weight percent of silicate bioceramic material CaO：42-50%, SiO2：48-52%, B2O3：0.3-2.4%, ZnO：0.2-3.0%, MgO：0.8-4.5%；By what is prepared in proportion Silicate bioceramic material powder adds dehydrated alcohol to carry out in ball mill mechanization ball milling 24 hours, and obtaining has 50-150 μm crystallite dimension superfines；
（c）The preparation of hydroxyapatite salt powder：The chemical component of hydroxyapatite salt powder：6 (OH) 2 of Ca10 (PO4), will be by hydroxyl Base apatite salt powder adds dehydrated alcohol to carry out in ball mill mechanization ball milling 24 hours, and obtaining has 50-150 μm of crystal grain ruler Very little superfines；
（d）Titanium alloy-silicate-hydroxy-apatite halite transition zone powder preparation：Configuration forms the titanium of more gradients from the inside to the outside Alloy-silicate-hydroxy-apatite halite transition zone is always divided into 5 layers, and innermost layer to outermost powder weight ratio is distinguished For：
First layer：Titanium alloy substrate powder：Silicate biomaterial powder=81.6：18.4；
The second layer：Titanium alloy substrate powder：Silicate biomaterial powder=72.4：27.6；
Third layer：Titanium alloy substrate powder：Silicate biomaterial powder=54：46；
4th layer：Hydroxyapatite salt powder：Silicate biomaterial powder=72.4：27.6；
Layer 5：Hydroxyapatite salt powder：Silicate biomaterial powder=81.6：18.4；
It prepares titanium alloy-silicate-hydroxy-apatite halite transition zone powder respectively according to weight ratio, adds dehydrated alcohol in ball It is carried out mechanization ball milling 24 hours in grinding machine, obtaining has 50-150 μm of crystallite dimension superfines.
CN201810971470.0A 2018-08-24 2018-08-24 Titanium alloy-silicate transition zone-hydroxy-apatite halite bioceramic preparation method Pending CN108863341A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810971470.0A CN108863341A (en) 2018-08-24 2018-08-24 Titanium alloy-silicate transition zone-hydroxy-apatite halite bioceramic preparation method

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201810971470.0A CN108863341A (en) 2018-08-24 2018-08-24 Titanium alloy-silicate transition zone-hydroxy-apatite halite bioceramic preparation method

Publications (1)

Publication Number Publication Date
CN108863341A true CN108863341A (en) 2018-11-23

Family

ID=64321443

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201810971470.0A Pending CN108863341A (en) 2018-08-24 2018-08-24 Titanium alloy-silicate transition zone-hydroxy-apatite halite bioceramic preparation method

Country Status (1)

Country Link
CN (1) CN108863341A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112207288A (en) * 2020-09-16 2021-01-12 山东工业陶瓷研究设计院有限公司 Metal ceramic composite part and preparation method thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1530670A (en) * 1975-12-30 1978-11-01 Sumitomo Chemical Co Endosseous implants
CN101053677A (en) * 2007-05-16 2007-10-17 贵州大学 Gradient biologically active ceramic coating material and its preparation method and product application
CN104710188A (en) * 2015-03-02 2015-06-17 浙江大学 Porous calc silicate bioceramic material, preparation method and application
CN104841018A (en) * 2015-04-21 2015-08-19 昆明理工大学 Multilayered biological composite material and preparation method thereof
CN106435544A (en) * 2016-11-09 2017-02-22 北京科技大学 Method for preparing nano-hydroxyapatite gradient coating on titanium alloy matrix
CN108273133A (en) * 2018-03-05 2018-07-13 北京科技大学 A kind of method that gel injection-moulding prepares biomedical alloy HA coatings

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1530670A (en) * 1975-12-30 1978-11-01 Sumitomo Chemical Co Endosseous implants
CN101053677A (en) * 2007-05-16 2007-10-17 贵州大学 Gradient biologically active ceramic coating material and its preparation method and product application
CN104710188A (en) * 2015-03-02 2015-06-17 浙江大学 Porous calc silicate bioceramic material, preparation method and application
CN104841018A (en) * 2015-04-21 2015-08-19 昆明理工大学 Multilayered biological composite material and preparation method thereof
CN106435544A (en) * 2016-11-09 2017-02-22 北京科技大学 Method for preparing nano-hydroxyapatite gradient coating on titanium alloy matrix
CN108273133A (en) * 2018-03-05 2018-07-13 北京科技大学 A kind of method that gel injection-moulding prepares biomedical alloy HA coatings

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
钱超等: "三维打印制备钛/羟基磷灰石复合体及功能梯度材料" *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112207288A (en) * 2020-09-16 2021-01-12 山东工业陶瓷研究设计院有限公司 Metal ceramic composite part and preparation method thereof

Similar Documents

Publication Publication Date Title
Kalita et al. CaO–P2O5–Na2O-based sintering additives for hydroxyapatite (HAp) ceramics
Kim et al. Calcium phosphates and glass composite coatings on zirconia for enhanced biocompatibility
Amaral et al. Densification route and mechanical properties of Si3N4–bioglass biocomposites
US8703294B2 (en) Bioactive graded zirconia-based structures
CN103599561B (en) A kind of preparation method of magnesium alloy/hydroxyapatite composite
Wang et al. In vitro degradation and surface bioactivity of iron-matrix composites containing silicate-based bioceramic
de Oliveira et al. Study of the porous Ti35Nb alloy processing parameters for implant applications
US20130150227A1 (en) Composite Bio-Ceramic Dental Implant and Fabricating Method Thereof
Zhang et al. Low elastic modulus Ti-Ag/Ti radial gradient porous composite with high strength and large plasticity prepared by spark plasma sintering
CN106119742B (en) A kind of titanium carbide crystal whisker toughened magnesium alloy bio-medical material of titanium oxide
Ouyang et al. Effect of composition on in vitro degradability of Ti–Mg metal-metal composites
CN107693848A (en) A kind of biomedical metallic material and preparation method thereof
Owoeye et al. Microstructure, phase and physical evaluation of non-bioactive wollastonite glass–Ceramic prepared from waste glass by sintering method
Chu et al. In vivo study on biocompatibility and bonding strength of Ti/Ti–20 vol.% HA/Ti–40 vol.% HA functionally graded biomaterial with bone tissues in the rabbit
Du et al. Development of non-toxic low-cost bioactive porous Ti–Fe–Si bulk metallic glass with bone-like mechanical properties for orthopedic implants
CN105886814B (en) A kind of implantable Bone Defect Repari implants magnesium alloy materials and preparation method thereof
Zhang et al. Designing a novel functional-structural NiTi/hydroxyapatite composite with enhanced mechanical properties and high bioactivity
CN108863341A (en) Titanium alloy-silicate transition zone-hydroxy-apatite halite bioceramic preparation method
CN109332700A (en) A kind of preparation method of TiB enhancing medical porous titanium
Deevil et al. International Symposium on Nickel and Iron Aluminides: Processing, Properties, and Applications
Kalita et al. Effects of MgO‐CaO‐P2O5‐Na2O‐based additives on mechanical and biological properties of hydroxyapatite
Zhang et al. Effect of calcium pyrophosphate on microstructural evolution and in vitro biocompatibility of Ti-35Nb-7Zr composite by spark plasma sintering
Masseli et al. Mechanical and physical characterization of hydroxyapatite/alumina biocomposites produced by the powder metallurgy route for biomedical applications
Ducheyne et al. Bioceramic composites
CN106924816B (en) Biodegradable magnesium-based metal ceramic composite material and preparation method and application thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WD01 Invention patent application deemed withdrawn after publication
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20181123