CN108853448A - A kind of Chinese medicine and preparation method thereof for treating cervical spondylosis - Google Patents
A kind of Chinese medicine and preparation method thereof for treating cervical spondylosis Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicines for treating cervical spondylosis, it is prepared from the following raw materials in parts by weight：1-5 parts of muscone, 2-10 parts of Radix Notoginseng, 8-15 parts of Radix Salviae Miltiorrhizae, 8-15 parts of cortex moutan, 30-50 parts of Radix Angelicae Pubescentis, 15-25 parts of rhizoma zingiberis, 15-25 parts of cloves, 8-15 parts of rheum officinale, 8-15 parts of radices trichosanthis, 8-15 parts of the root of Dahurain angelica, 2-10 parts of borneol, 1-5 parts of menthol.The present invention has the function of that dispelling wind and eliminating dampness, warming and activating meridian, promoting blood circulation and stopping pain, pharmacodynamic test proof have effects that anti-inflammatory and antalgic according to differentiation of tcm, scientific composition, provided prescription.During prescription, the characteristics of the characteristics of also fully taking into account exterior-applied formulation, especially Transdermal absorption, selected Chinese medicine has infiltration rate fast, works the features such as rapid, lasting.
Description
Technical field
The invention belongs to the field of Chinese medicines, and in particular to a kind of Chinese medicine and preparation method thereof for treating cervical spondylosis.
Background technique
Cervical spondylosis (cervical spondylosis, CS) is also known as cervical spine syndrome, is osteoarthritis of cervical spine, Hypertrophic neck
Vertebra inflammation, the general name of cervical syndrome, Cervical disc extrusion are a kind of illness that basis is changed into degeneration pathology.
Strain for a long time mainly due to cervical vertebra, osteoproliferation or Disc herniation, ligament thicken, cause cervical vertebra spinal cord, nerve root or vertebra dynamic
Arteries and veins is pressurized, and a series of clinical syndrome of dysfunctions occurs.It has disease incidence high, and treatment time is long, easily multiple after treatment
The features such as hair.Cervical spondylosis disease incidence increases year by year, is then within 60 years old there are about 25% morbidity in 50 years old or so crowd according to statistics
50%, 70 years old or so is almost 100%, and nerve root cervical vertebra sickness disease incidence highest (50%-60%) in cervical spondylosis parting, and 30
Year old or more the worker Yi Fa that bows, and with the change of life and work mode, computer it is widely available, cervical spondylosis has rapidly
Increase and rejuvenation trend, brought the multiple burden of body, psychology and economy etc., be also increasingly subject to society and
The attention of scholars.
Motherland's medicine thinks cervical spondylosis mainly because neck toils away, and derangement of Qi and blood, wind-cold damp pathogen is detained passages through which vital energy circulates, retardance warp
Caused by network, the rules for the treatment of are dispelling wind and eliminating dampness, warming and activating meridian, promoting blood circulation and stopping pain.Massage treatment in motherland's medicine is presently preferred
Non-drug conservative therapy method.And Chinese medicine is based on activating microcirculation and removing stasis medicinal, it is also patient that dialectical treatmert is carried out on the basis of activating microcirculation and removing stasis medicinal
The conservative therapy method being willing to accept, and have been used to all various necks other than the myeloid form of serious cervical spinal cord compression
Vertebra disease, can play certain improvement local blood circulation, loosen spasm muscle, alleviate symptom, the effect of anti-inflammatory analgetic.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine for the treatment of cervical spondylosis curative for effect, few side effects, the present invention is also mentioned
For the preparation method of the Chinese medicine.
Chinese medicine provided by the invention is prepared from the following raw materials in parts by weight：It is 1-5 parts of muscone, 2-10 parts of Radix Notoginseng, red
8-15 parts of ginseng, 8-15 parts of cortex moutan, 30-50 parts of Radix Angelicae Pubescentis, 15-25 parts of rhizoma zingiberis, 15-25 parts of cloves, 8-15 parts of rheum officinale, radices trichosanthis 8-
15 parts, 8-15 parts of the root of Dahurain angelica, 2-10 parts of borneol, 1-5 parts of menthol.
Preferably, the Chinese medicine is prepared from the following raw materials in parts by weight：2 parts of muscone, 4 parts of Radix Notoginseng, 12 parts of Radix Salviae Miltiorrhizae,
It is 12 parts of cortex moutan, 40 parts of Radix Angelicae Pubescentis, 20 parts of rhizoma zingiberis, 20 parts of cloves, 12 parts of rheum officinale, 12 parts of radices trichosanthis, 12 parts of the root of Dahurain angelica, 4 parts of borneol, thin
2 parts of lotus brain.Using the raw material proportioning, the anti-inflammatory pain-stopping effect of Chinese medicine is best, and curative effect is best.
By the above raw material proportioning, Chinese medicine of the present invention can be made to the dosage form of any suitable clinical use, including but
It is not limited to oral preparation, external preparation and injection, but injection side effect is larger, in contrast, oral preparation and external application system
The safety of agent is higher.Applicant also passes through a large amount of Experimental Comparison and finds, for the present invention, external preparation has than oral preparation
There is better anti-inflammatory pain-stopping effect, and it is rapider to work, side effect is less, and more convenient to use, therefore, the present invention more manages
The dosage form thought is externally applied drug.
The externally applied drug includes but is not limited to gelling agent, ointment, rubber paste, spray, aerosol, lotion, patch etc.,
Applicant further passes through a large amount of Experimental Comparison and finds, for the present invention, gelling agent not only has Drug Percutaneous Absorption speed
Faster, the advantages that anti-inflammatory pain-stopping effect is more preferable, and skin irritation and allergic reaction incidence are lower compared with other dosage forms,
Therefore, the optimal dosage form of the present invention is gelling agent.
When gelling agent is made in Chinese medicine of the present invention, it is necessary first to carry out extraction appropriate to medicinal material, the purpose of extraction is
It is sufficiently active constituent-enriched, invalid or harmful components are reduced, to improve the curative effect of drug and reduce side effect.But Chinese medicine
Ingredient is extremely complex, and those skilled in the art can not know that in advance which is effective component in Chinese medicine, which is invalid or has
Evil ingredient, can only evaluate the extracting method of Chinese medicine by validity and safety.
Firstly, the present invention extracts the nine taste medicinal material such as Radix Notoginseng, Radix Salviae Miltiorrhizae, cortex moutan using 30-70% ethyl alcohol.This
Field technical staff both knows about, and second alcohol and water is the most common two kinds of Extraction solvents of Chinese medicine, but the polarity of the two has very big difference
, do not cause the ingredient extracted also entirely different, for example, in the water extract of Chinese medicine polysaccharide, tannin, amino acid occupy it is very big
Ratio, and in ethanol extract it is more flavones, anthraquinone, saponin component, and polyoses content is very low.In addition, the concentration of ethyl alcohol
The type and content of ingredient are influenced also very greatly, liposoluble constituent content is higher in the more high then extract of usually ethanol concentration, second
Water soluble ingredient content is higher in the more low then extract of determining alcohol.Applicant by largely test it was found that, using 30-
70% ethyl alcohol extract, obtained Chinese medicine anti-inflammatory pain-stopping effect is more preferable, and side effect is less, in addition Drug Percutaneous Absorption speed faster,
It works faster, wherein 50% ethyl alcohol extraction effect is best.
Secondly, extracting method can be using the common decoction in this field, heat reflux, temperature leaching, leakage, ultrasonic, overcritical etc.
Method, but be different extracting method and also have significant impact to the type and content of ingredient, for example, it is overcritical mainly extract be
Volatile liposoluble constituent；What decoction, reflux, temperature leaching were mainly extracted is thermostabilization ingredient, and volatile and degradable ingredient
Extracted amount is seldom；For opposite thermal extraction, leakage, ultrasound are due to being to extract under cryogenic, containing more in extract
More thermally labile components.Applicant by largely test it was found that, the present invention is extracted using leakage, and obtained Chinese medicine is anti-
Scorching analgesic effect is more preferable, and side effect is less, and Transdermal absorption effect is also more preferable.
Finally, applicant has carried out a large number of experiments screening to gel-type vehicle, it is final to determine that matrix is carbomer and azone
Mixed aqueous solution, which can further decrease skin irritation and allergic reaction, and improve Transdermal absorption effect.
In conclusion preparation method provided by the invention, includes the following steps：
1) Radix Notoginseng, Radix Salviae Miltiorrhizae, cortex moutan, Radix Angelicae Pubescentis, rhizoma zingiberis, cloves, rheum officinale, radices trichosanthis, the root of Dahurain angelica are ground into coarse powder, then used
30-70% ethyl alcohol extracts, and collects extracting solution, recycles ethyl alcohol and is condensed into thick paste；
2) borneol, a small amount of ethyl alcohol of menthol are dissolved, is then added to gel-type vehicle together with muscone, thick paste
In, up to gel after stirring homogeneous.
The matrix is the mixed aqueous solution of carbomer and azone, by weight, wherein azone, 1- containing 0.1-1%
3% carbomer, water are surplus.
Concentration of alcohol involved in the present invention is volumetric concentration, such as 50% ethyl alcohol, refers to every 100ml ethanol water
In solution, contain ethyl alcohol 50ml.
Beneficial effects of the present invention：
The present invention has dispelling wind and eliminating dampness, warming and activating meridian, work according to differentiation of tcm, scientific composition, provided prescription
The effect of blood and relieving pain, pharmacodynamic test proof have effects that anti-inflammatory and antalgic.During prescription, exterior-applied formulation is also fully taken into account
The characteristics of, especially Transdermal absorption the characteristics of, selected Chinese medicine have infiltration rate it is fast, work it is rapid, lasting the features such as.
Preparation method provided by the invention comprehensively considers validity, safety, percutaneous absorbability and the use of drug just
Benefit, active component content is high in product obtained, and impurity is few, and these active constituents have molecular weight more appropriate,
Polarity and dissolubility, itself just has the characteristics that suitable human skin, under the action of penetrating agent, is more easier to penetrate skin angle
Matter layer, to more sufficiently, promptly be absorbed by the body.
Specific embodiment
The present invention is described in detail below by specific embodiment.
Embodiment 1
Muscone 200g, Radix Notoginseng 400g, Radix Salviae Miltiorrhizae 1200g, cortex moutan 1200g, Radix Angelicae Pubescentis 4000g, rhizoma zingiberis 2000g, cloves
2000g, rheum officinale 1200g, radices trichosanthis 1200g, root of Dahurain angelica 1200g, borneol 400g, menthol 200g.
1) Radix Notoginseng, Radix Salviae Miltiorrhizae, cortex moutan, Radix Angelicae Pubescentis, rhizoma zingiberis, cloves, rheum officinale, radices trichosanthis, the root of Dahurain angelica are ground into coarse powder, then used
50% ethyl alcohol leakage is extracted until color becomes clear, and collection extracting solution recycles ethyl alcohol and is condensed into thick paste (about 3Kg)；
2) borneol, a small amount of ethyl alcohol of menthol are dissolved, is then added to gel-type vehicle together with muscone, thick paste
In (10Kg), up to gel after stirring homogeneous.
The matrix be carbomer and azone mixed aqueous solution, by weight, wherein containing 0.4% azone, 2.5%
Carbomer, water is surplus.
Embodiment 2
Muscone 100g, Radix Notoginseng 200g, Radix Salviae Miltiorrhizae 1500g, cortex moutan 1500g, Radix Angelicae Pubescentis 3000g, rhizoma zingiberis 2500g, cloves
2500g, rheum officinale 1500g, radices trichosanthis 1500g, root of Dahurain angelica 800g, borneol 1000g, menthol 100g.
1) Radix Notoginseng, Radix Salviae Miltiorrhizae, cortex moutan, Radix Angelicae Pubescentis, rhizoma zingiberis, cloves, rheum officinale, radices trichosanthis, the root of Dahurain angelica are ground into coarse powder, then used
70% ethyl alcohol leakage is extracted until color becomes clear, and collection extracting solution recycles ethyl alcohol and is condensed into thick paste (about 3Kg)；
2) borneol, a small amount of ethyl alcohol of menthol are dissolved, is then added to gel-type vehicle together with muscone, thick paste
In (10Kg), up to gel after stirring homogeneous.
The matrix be carbomer and azone mixed aqueous solution, by weight, wherein containing 0.8% azone, 1.5%
Carbomer, water is surplus.
Embodiment 3
Muscone 500g, Radix Notoginseng 1000g, Radix Salviae Miltiorrhizae 800g, cortex moutan 800g, Radix Angelicae Pubescentis 5000g, rhizoma zingiberis 1500g, cloves
1500g, rheum officinale 800g, radices trichosanthis 800g, root of Dahurain angelica 1500g, borneol 200g, menthol 500g.
1) Radix Notoginseng, Radix Salviae Miltiorrhizae, cortex moutan, Radix Angelicae Pubescentis, rhizoma zingiberis, cloves, rheum officinale, radices trichosanthis, the root of Dahurain angelica are ground into coarse powder, then used
30% ethyl alcohol leakage is extracted until color becomes clear, and collection extracting solution recycles ethyl alcohol and is condensed into thick paste (about 3Kg)；
2) borneol, a small amount of ethyl alcohol of menthol are dissolved, is then added to gel-type vehicle together with muscone, thick paste
In (10Kg), up to gel after stirring homogeneous.
The matrix is the mixed aqueous solution of carbomer and azone, by weight, wherein containing 0.2% azone, 3%
Carbomer, water are surplus.
Embodiment 4
Muscone 200g, Radix Notoginseng 400g, Radix Salviae Miltiorrhizae 1200g, cortex moutan 1200g, Radix Angelicae Pubescentis 4000g, rhizoma zingiberis 2000g, cloves
2000g, rheum officinale 1200g, radices trichosanthis 1200g, root of Dahurain angelica 1200g, borneol 400g, menthol 200g.
1) Radix Notoginseng, Radix Salviae Miltiorrhizae, cortex moutan, Radix Angelicae Pubescentis, rhizoma zingiberis, cloves, rheum officinale, radices trichosanthis, the root of Dahurain angelica are ground into coarse powder, then used
30% ethyl alcohol leakage is extracted until color becomes clear, and collection extracting solution recycles ethyl alcohol and is condensed into thick paste, is ground into after being dried under reduced pressure
Fine powder；
2) fine powder for obtaining step 1) and borneol, menthol, muscone mix, and add starch mixing, use capsule
Filling, is made capsule.
Embodiment 5
Muscone 200g, Radix Notoginseng 400g, Radix Salviae Miltiorrhizae 1200g, cortex moutan 1200g, Radix Angelicae Pubescentis 4000g, rhizoma zingiberis 2000g, cloves
2000g, rheum officinale 1200g, radices trichosanthis 1200g, root of Dahurain angelica 1200g, borneol 400g, menthol 200g.
1) Radix Notoginseng, Radix Salviae Miltiorrhizae, cortex moutan, Radix Angelicae Pubescentis, rhizoma zingiberis, cloves, rheum officinale, radices trichosanthis, the root of Dahurain angelica are ground into coarse powder, then used
50% ethyl alcohol leakage is extracted until color becomes clear, and collection extracting solution recycles ethyl alcohol and is condensed into thick paste (about 3Kg)；
2) borneol, a small amount of ethyl alcohol of menthol are dissolved, is then added to together with muscone, thick paste by rubber, pine
In the rubber paste matrix that perfume, lanolin, zinc oxide form, routinely rubber paste is made in technique.
The experiment of 6 caused by dimethylbenzene xylene rat auricle edema anti-inflammatory effect of embodiment
SPF grades rat 36,180~220g of weight, half male and half female.36 rats are randomly divided into 6 groups, every group 6,
The two-sided smearing dimethylbenzene of every rat auris dextra, 50ul/ only, are administered after 30min by following grouping：Blank group does not give any medicine
Object；1,2,3 group of embodiment is given gel 0.4g respectively, and suitably massage promotes drug absorption after two-sided smearing rat auris dextra；Implement
Capsule 's content 0.5mg raw medicinal herbs/Kg is given in 4 groups of stomach-fillings of example；5 groups of embodiment are given rubber paste 0.4g, two-sided smearing Rat Right
Suitably massage promotes drug absorption after ear.Cervical dislocation puts to death animal after 1h, with 6mm diameter punch difference bilateral ear in phase
Round auricle is laid with position, claims quality with precision torsion balance, calculates swelling and swelling rate, the results are shown in Table 1.
The influence of the drug paraxylene of the present invention of table 1 cause rat auricle edema
| Group | Left ear weight/mg | Auris dextra weight/mg | Swelling/mg | Swelling rate (%) |
| Blank group | 18.91±1.80 | 25.90±3.99 | 6.99±3.74 | 36.96 |
| Example 1 group | 19.15±2.32 | 21.50±2.73* | 2.35±1.10# | 12.27# |
| 2 groups of embodiment | 18.50±3.31 | 21.98±3.68* | 3.48±2.42* | 18.81* |
| 3 groups of embodiment | 18.65±2.32 | 22.61±1.81 | 3.96±2.09* | 21.23* |
| 4 groups of embodiment | 18.08±2.34 | 23.86±2.38 | 5.78±1.61 | 31.97 |
| 5 groups of embodiment | 18.90±2.28 | 23.02±2.64 | 4.12±2.17* | 21.80* |
Note：Compared with blank group, * P<0.05.#P<0.01.
From the above test results, it can be seen that drug of the present invention can mitigate the swelling of caused by dimethylbenzene xylene rat auricle, explanation
With anti-inflammatory effect, wherein gelling agent effect is best, and rubber paste takes second place, and oral drugs effect is poor.
7 rat hotplate method analgesic test of embodiment
SPF grades rat 30,180~220g of weight, half male and half female.36 rats are randomly divided into 6 groups, every group 6.
Every rat first measures the pain threshold before administration, is then administered by following grouping：Blank group does not give any drug；Embodiment 1,
2, gel 0.4g is given respectively for 3 groups, suitably massage promotes drug absorption after smearing rat right hind leg；4 groups of stomach-fillings of embodiment are given
Capsule 's content 0.5mg raw medicinal herbs/Kg；5 groups of embodiment are given rubber paste 0.4g, and suitably massage promotes after smearing rat right hind leg
Drug absorption.It is administered once a day, successive administration 3d.The Pain Regulation In The Rat of 0.5h, 1.0h, 2.0h after the last administration are measured, as a result
It is shown in Table 2.
The influence that the drug of the present invention of table 2 tests rat hotplate
Note：Compared with before administration, #P<0.01, * P<0.05.
From the above test results, it can be seen that drug of the present invention can improve the pain threshold of hot plate method induced pain rat, illustrate have
There is analgesic activity, gelling agent effect is best, and rubber paste takes second place, and oral drugs effect is poor, and wherein embodiment 1 also has the speed that works
The advantages of degree is most fast, efficiency time longest.
8 typical case of embodiment
Lee, male, 46 years old, neck stiffness, limitation of activity, headache and dizzy, in 6 monthly income our hospital treatment in 2017.Through having looked into
It bows work and chronic strain history for a long time, lesion cervical spine, often there is tenderness at upper angle in Ipsilateral shoulder blade, can touch streak hard
Knot.X-ray normotopia is taken the photograph piece and is shown, uncovertebral joint hyperplasia, it is skewed that mouth-open has chisel-like to dash forward, and side position takes the photograph piece and shows that cervical curvature straightens,
Narrowing of intervertebral space has osteoproliferation or ligament calcification.Using Chinese medicine external of the present invention, according to sore spot size take appropriate Tu in
Skin, 2 times a day.Symptom is substantially reduced immediately after medication, checks after 30 days, and clinical symptoms all disappear, and positive sign is complete
Improve, neck activity is freely.
Claims (8)
1. a kind of Chinese medicine for treating cervical spondylosis, it is characterised in that be prepared from the following raw materials in parts by weight：
1-5 parts of muscone, 2-10 parts of Radix Notoginseng, 8-15 parts of Radix Salviae Miltiorrhizae, 8-15 parts of cortex moutan, 30-50 parts of Radix Angelicae Pubescentis, 15-25 parts of rhizoma zingiberis,
15-25 parts of cloves, 8-15 parts of rheum officinale, 8-15 parts of radices trichosanthis, 8-15 parts of the root of Dahurain angelica, 2-10 parts of borneol, 1-5 parts of menthol.
2. the Chinese medicine for the treatment of cervical spondylosis as described in claim 1, it is characterised in that be prepared from the following raw materials in parts by weight：
2 parts of muscone, 4 parts of Radix Notoginseng, 12 parts of Radix Salviae Miltiorrhizae, 12 parts of cortex moutan, 40 parts of Radix Angelicae Pubescentis, 20 parts of rhizoma zingiberis, 20 parts of cloves, rheum officinale 12
Part, 12 parts of radices trichosanthis, 12 parts of the root of Dahurain angelica, 4 parts of borneol, 2 parts of menthol.
3. the Chinese medicine for the treatment of cervical spondylosis as claimed in claim 1 or 2, it is characterised in that：The Chinese medicine is externally applied drug.
4. the Chinese medicine for the treatment of cervical spondylosis as claimed in claim 3, it is characterised in that：The externally applied drug is gel.
5. a kind of method for preparing Chinese medicine described in claim 4, it is characterised in that include the following steps：
1) Radix Notoginseng, Radix Salviae Miltiorrhizae, cortex moutan, Radix Angelicae Pubescentis, rhizoma zingiberis, cloves, rheum officinale, radices trichosanthis, the root of Dahurain angelica are ground into coarse powder, then use 30-
70% ethyl alcohol extracts, and collects extracting solution, recycles ethyl alcohol and is condensed into thick paste；
2) borneol, a small amount of ethyl alcohol of menthol are dissolved, is then added in gel-type vehicle, stirs together with muscone, thick paste
It mixes after homogeneous up to gel.
6. the preparation method of Chinese medicine as claimed in claim 5, it is characterised in that：The extraction is that leakage is extracted.
7. the preparation method of Chinese medicine as claimed in claim 5, it is characterised in that：The ethyl alcohol is 50% ethyl alcohol.
8. the preparation method of Chinese medicine as claimed in claim 5, it is characterised in that：The matrix is the mixing water of carbomer and azone
Solution, by weight, wherein the carbomer of azone, 1-3% containing 0.1-1%, water are surplus.
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| CN109966465A (en) * | 2019-04-23 | 2019-07-05 | 杨峰 | A kind of drug and preparation method thereof for treating cervical vertebra |
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| CN1357377A (en) * | 2001-12-21 | 2002-07-10 | 王全江 | Chinese medicine liniment for treating cervical vertebra disease and its prepn |
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| CN1357377A (en) * | 2001-12-21 | 2002-07-10 | 王全江 | Chinese medicine liniment for treating cervical vertebra disease and its prepn |
| CN1895291A (en) * | 2006-06-09 | 2007-01-17 | 陈永丽 | Nano-Chinese medicinal biological product and its preparation |
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| CN109966465A (en) * | 2019-04-23 | 2019-07-05 | 杨峰 | A kind of drug and preparation method thereof for treating cervical vertebra |
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