CN108853440A - 一种治疗甲状腺肿瘤的中药膏 - Google Patents
一种治疗甲状腺肿瘤的中药膏 Download PDFInfo
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- CN108853440A CN108853440A CN201811144810.9A CN201811144810A CN108853440A CN 108853440 A CN108853440 A CN 108853440A CN 201811144810 A CN201811144810 A CN 201811144810A CN 108853440 A CN108853440 A CN 108853440A
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- chinese medicinal
- medicinal ointment
- radix angelicae
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Abstract
本发明涉及一种治疗甲状腺肿瘤的中药膏,由重量计的:海藻、昆布、青皮、陈皮、连翘、猫爪草、蜂房、乳香、没药、莪术、浙贝母、川芎、当归、甘草、独活、半夏、夏枯草、牡蛎、海蛤壳、黄药子、柴胡、合欢皮、鬼箭羽、冰片、穿山龙和蜂蜜制成,本发明为纯中药配制,具有行气活血、化痰软坚、消瘿散结之功效,能够有效改善甲状腺肿瘤患者颈部肿大的症状,提高患者生活质量,是甲状腺肿瘤治疗药物上的创新,经济和社会效益显著。
Description
技术领域
本发明涉及中药,特别是一种治疗甲状腺肿瘤的中药膏。
背景技术
甲状腺肿瘤属于祖国医学中“石瘿”、“肉瘿”、“气瘿”等“瘿瘤”的范畴,甲状腺肿瘤患者的发病多与情志因素密切相关,由于长期情志不舒,忧思郁怒,肝郁化火,灼津成痰,痰气郁热互结于颈部则颈部肿胀;或脾失健运,痰湿内生,随肝火上逆博结于颈部则肿;气病及血,痰浊阻络则气滞痰瘀互结,近年来甲状腺肿瘤的发病率逐渐增高,特别是在内分泌系统肿瘤和头颈部肿瘤中发病率跃居第一位,在人体所有恶性肿瘤中,甲状腺癌所占比例接近 1%。甲状腺肿瘤包括甲状腺腺瘤和甲状腺癌,与后者相比,甲状腺腺瘤通常指呈良性生长的瘤性组织,并有完整的包膜包裹。甲状腺良性肿瘤主要包括甲状腺腺瘤、甲状腺囊肿、结节性甲状腺肿,其中结节性甲状腺肿发病率较高,在我国发病率约为 4-7% ,并且可恶变为甲状腺癌或同时伴发甲状腺癌。甲状腺肿瘤通常发病隐匿,以甲状腺结节表现者居多,不易早期发现,患者可能偶然会触摸到颈部单个或多个、质硬、高低不平、不对称性的肿块,多数并无自觉不适。疾病进展后可因肿物增大压迫临近组织器官,产生一系列的临床症状,从而影响患者生活质量。近年来国内外对甲状腺肿瘤的治疗方法不断更新,主要的治疗有手术、内分泌药物治疗、碘放射治疗及基因治疗等,不仅花费昂贵,且复发率高、副作用明显,其治疗效果并不尽人意,因此,其药物上的改进和创新势在必行。
发明内容
针对上述情况,为解决现有技术之缺陷,本发明之目的就是提供一种治疗甲状腺肿瘤的中药膏,可有效解决患者颈前肿大减小或消失,控制病情,缓解症状,缩短病程,提高患者生活质量的问题。
本发明解决的技术方案是,该中药膏由重量计的:海藻20-30g、昆布20-30g、青皮10-20g、陈皮20-30g、连翘20-30g、猫爪草10-20g、蜂房10-20g、乳香10-20g、没药10-20g、莪术10-20g、浙贝母10-20g、川芎20-30g、当归20-30g、甘草15-20g、独活10-15g、半夏10-20g、夏枯草20-30g、牡蛎20-30g、海蛤壳20-30g、黄药子10-15g、柴胡15-30g、合欢皮10-20g、鬼箭羽10-20g、冰片10-20g、穿山龙10-30g和蜂蜜10-20g制成,将上述除蜂蜜外的药物研成粉末,将蜂蜜与粉末混合在一起,加开水搅拌,直至变成均匀的药糊,即成。
本发明为纯中药配制,具有行气活血、化痰软坚、消瘿散结之功效,能够有效改善甲状腺肿瘤患者颈部肿大的症状,提高患者生活质量,是甲状腺肿瘤治疗药物上的创新,经济和社会效益显著。
具体实施方式
以下结合具体情况和实施例对本发明的具体实施方式作进一步详细说明。
实施例1
本发明一种治疗甲状腺肿瘤的中药膏,该中药膏由重量计的:海藻23-27g、昆布23-27g、青皮13-17g、陈皮23-27g、连翘23-27g、猫爪草13-17g、蜂房13-17g、乳香13-17g、没药13-17g、莪术13-17g、浙贝母13-17g、川芎23-27g、当归23-27g、甘草16-18g、独活11-13g、半夏13-17g、夏枯草23-27g、牡蛎23-27g、海蛤壳23-27g、黄药子11-13g、柴胡20-25g、合欢皮13-17g、鬼箭羽13-17g、冰片13-17g、穿山龙15-25g和蜂蜜13-17g制成,将上述除蜂蜜外的药物研成粉末,将蜂蜜与粉末混合在一起,加开水搅拌,直至变成均匀的药糊,即成。
实施例2
本发明一种治疗甲状腺肿瘤的中药膏,该中药膏由重量计的:海藻30g、昆布30g、青皮20g、陈皮30g、连翘30g、猫爪草20g、蜂房20g、乳香20g、没药20g、莪术20g、浙贝母20g、川芎30g、当归30g、甘草20g、独活15g、半夏20g、夏枯草30g、牡蛎30g、海蛤壳30g、黄药子15g、柴胡30g、合欢皮20g、鬼箭羽20g、冰片20g、穿山龙30g和蜂蜜20g制成,制备方法同实施例1。
实施例3
本发明一种治疗甲状腺肿瘤的中药膏,该中药膏由重量计的:海藻25g、昆布25g、青皮15g、陈皮25g、连翘25g、猫爪草15g、蜂房15g、乳香15g、没药15g、莪术15g、浙贝母15g、川芎25g、当归25g、甘草17g、独活12g、半夏15g、夏枯草25g、牡蛎25g、海蛤壳25g、黄药子12g、柴胡22g、合欢皮15g、鬼箭羽15g、冰片15g、穿山龙20g和蜂蜜15g制成,制备方法同实施例1。
实施例4
本发明一种治疗甲状腺肿瘤的中药膏,该中药膏由重量计的:海藻20g、昆布20g、青皮10g、陈皮20g、连翘20g、猫爪草10g、蜂房10g、乳香10g、没药10g、莪术10g、浙贝母10g、川芎20g、当归20g、甘草15g、独活10g、半夏10g、夏枯草20g、牡蛎20g、海蛤壳20g、黄药子10g、柴胡15g、合欢皮10g、鬼箭羽10g、冰片10g、穿山龙10g和蜂蜜10g制成,制备方法同实施例1。
在上述组分中,其中:
海藻:消痰软坚,利水消肿。用于瘿瘤,瘰疬,睾丸疼痛;痰饮水肿。
昆布:消痰软坚,利水消肿。用于瘿瘤,瘰疬,睾丸疼痛;痰饮水肿。
青皮:舒肝破气,消积化滞。用于肝郁气滞证;气滞脘腹疼痛;食积腹痛;癥瘕积聚,久疟痞块。
陈皮:理气健脾,燥湿化痰。用于脾胃气滞证;呕吐、呃逆;温痰、寒痰咳嗽;胸痹。
连翘:清热解毒,消肿散结,疏风散热。用于痈肿疮疡、瘰疬痰核;风热外感,温病初起;热淋涩痛。
猫爪草:化痰散结,解毒消肿。用于瘰疬痰核;疔疮、解毒消肿。
蜂房:攻毒杀虫,祛风止痛。用于疮疡肿毒,乳痈,瘰疬,顽癣瘙痒,癌肿;风湿痹痛,牙痛,风疹瘙痒。
乳香:活血行气止痛,消肿生肌。用于跌打损伤,疮疡痈肿;气滞血瘀痛证。
没药:活血止痛,消肿生肌。用于跌打损伤,疮疡痈肿;气滞血瘀痛证。
莪术:破血行气,消积止痛。用于癥瘕积聚,经闭,心腹瘀痛;食积脘腹胀痛。
浙贝母:清热化痰,散结消痈。用于风热、痰热咳嗽;瘰疬, 乳痈疮毒,肺痈。
川芎:活血行气,祛风止痛。用于血瘀气滞痛证;头痛、风湿痹痛。
当归:补血调经,活血止痛,润肠通便。用于血虚诸证;血虚血瘀,月经不调,闭经,痛经;虚寒性腹痛,跌打损伤,痈疽疮疡,风寒痹痛。
甘草:补脾益气,去痰止咳,缓急止痛,清热解毒,调和诸药。用于心气不足,脉结代、心悸动;脾气虚证;咳嗽;脘腹四肢挛急疼痛;热毒疮疡,咽喉肿痛,药食中毒;调和药性。
独活:祛风湿,止痛,解表。用于风寒湿痹;风寒挟湿表证;少阴头痛。
半夏:燥湿化痰,降逆止呕,消痞散结;外用消肿止痛。用于湿痰、寒痰证;呕吐;心下痞,结胸,梅核气;瘿瘤,痰核,痈疽肿毒,毒蛇咬伤。
夏枯草:清热泻火,明目,散结消肿。用于目赤肿痛,头痛眩晕,目珠夜痛;瘰疬,瘿瘤;乳痈肿毒。
牡蛎:重镇安神,平肝潜阳,软坚散结,收敛固涩。应用于心神不宁,惊悸失眠;肝阳上亢,头晕目眩;痰核,瘰疬,瘿瘤,癥瘕积聚;滑脱诸证。
海蛤壳:清热化痰,软坚散结。用于肺热,痰热咳喘;瘿瘤,痰核。
黄药子:化痰散结消瘿,清热解毒。用于瘿瘤;疮疡肿瘤,咽喉肿痛,毒蛇咬伤。
柴胡:解表退热,疏肝解郁,升举阳气。用于表证发热,少阳证;肝郁气滞;气虚下陷,脏器脱垂。
合欢皮:解郁安神,活血安神。用于心神不宁,忿怒忧郁,烦躁失眠;跌打损伤,血瘀肿痛;肺痈,疮痈肿毒。
鬼箭羽:破血,通经,杀虫。用于经闭,癥瘕,产后瘀滞腹痛,虫积腹痛。
冰片:开窍醒神,清热止痛。用于闭证神昏;目赤肿痛,喉痹口疮;疮疡肿痛,疮溃不破,水火烫伤。
穿山龙:祛风湿,活血通络,清肺化痰。用于风湿痹证;痰热咳喘。
上述组份科学、合理配伍,互相支持,具有行气活血、化痰软坚、消瘿散结之功效,能够有效改善甲状腺肿瘤患者颈部肿大的症状,提高患者生活质量,疗效好,用药安全,并经临床试验取得了很好的效果,有关临床资料如下:
(一)、诊断标准:
参考中华医学会内分泌学分会《中国甲状腺疾病诊治指南》并结合临床,制定标准如下:
(1)症状:患者颈前区可见肿大,可有颈部不适感或憋气感,无红、肿、热、痛。
(2)体征:触及单侧或双侧甲状腺肿大,触诊一个及以上结节,界清,无压痛,可随吞咽上下活动,无震颤,听诊无血管杂音。临床上甲状腺肿大分为三度:I°外观未见肿大,能触及,其肿大不超过胸锁乳突肌内缘;II°外观可见肿大,能触及,肿大范围在胸锁乳突肌内缘及外缘之间;Ⅲ°甲状腺肿大外观明显可见,且超出胸锁乳突肌外缘。
(3)影像学检查:甲状腺彩超检查发现甲状腺有结节存在。
(4)血清学检查:甲状腺激素水平某一项或几项升高。
(5)甲状腺细针穿刺细胞学检查:对直径超过 1cm,超声检查有恶性可能的结节需在超声引导下进行细针穿刺,并送病理进行细胞学检查,结果符合甲状腺肿瘤的病理诊断标准。
纳入标准:
(1) 符合诊断标准;
(2) 年龄在18-65岁之间的患者;
(3) 生存期>6 个月;
(4) 无明显肝、肾功能损害及严重心肺疾患;
(5)患者知情同意,愿意配合治疗。
排除标准:
(1)不符合上述纳入标准的患者;
(2)患者合并严重心脏病、严重肝脏疾病,肾脏疾病,代谢紊乱等;
(3)处于妊娠期、哺乳期或精神病患者;
(4)对本药物过敏明显者;
(5)未按规定用药,无法判断疗效,或资料不全等影响疗效或安全性判断者。
(三)、疗效评定标准:
参照《中药新药临床研究指导原则》拟定
临床痊愈:肿物不能触及,最大肿物直径<0.3cm,临床症状完全消失,疗效指数为100%;显效:最大肿物直径缩小>50%;临床症状明显好转,或疗效指数>60%;
有效:最大肿物直径缩小>30%以上,临床症状有所好转,或疗效指数在30%-60%之间;
无效:最大肿物直径无明显缩小,临床症状无明显好转,或疗效指数<30%;
疗效指数=[治疗前症状积分一治疗后症状积分/治疗前症状积分]×100%。
(四)、治疗方案:
对诊断为甲状腺肿瘤的患者,用本发明的中药膏进行外用治疗,取适量本发明中药膏,用吹风机或热水瓶加热至软化,涂于无纺布上,制成敷贴,每日一次,晚上贴敷,每次持续4-8个小时,7天为一个疗程,12个疗程后统计疗效。
(五)、统计学处理:
入选患者共162例,其中男41例,女121例,年龄为18-65岁。按上述(四)治疗方案,外敷本发明给出的中药膏,12个疗程后统计,临床痊愈有效9例、显效82例、有效13例,总有效率达86.0%,表明该发明中药膏治疗甲状腺肿瘤症效果显著,达到了临床治疗目的,并且在治疗过程中,未见明显不良反应。
(六)、典型病例
为了更详细的说明治疗情况,以下给出典型病例及治疗的疗效情况:
病例1:张某,女性,58岁,3年前无明显原因颈部肿大,未予处理及正规治疗,1周前自觉颈部较前明显增大,偶伴颈部憋闷感;为求系统诊断治疗来我科门诊治疗;触诊颈部不适,甲状腺Ⅱ度肿大,质韧;辅助检查:甲功提示FT3增高,FT4、TSH未见明显异常;彩超:右侧叶可见数个低回声结节,较大者范围约17×15.5mm,低回声不均质结节,边界清内回声不均匀,CDFI:血流信号丰富;左侧叶可见数个低回声结节,较大者6.9×3.3mm,边界清,未见明显血流信号;右侧颈部可见数个淋巴结回声,较大者11.7×6.8mm,边界清形态规整,皮髓质分解清;细针穿刺排除甲状腺癌。现症见:颈部偶感不适、有憋闷感,恶寒,易汗出,活动后明显,偶伴乏力、头蒙,大便干,小便黄;舌质红,苔黄,脉弦;诊断为“甲状腺肿瘤”,外敷本发明中药膏治疗4个疗程后颈前触诊轻微变软,憋闷感消失,伴颈部不适,彩超提示双侧甲状腺结节未见明显缩小;8个疗程后,肿块明显减小,偶伴颈部不适,彩超示:右侧叶较大低回声结节约10×9.1 mm、左侧叶较大者5.2×3.4 mm、颈部淋巴结较大者9.3×5.2mm;12个疗程后,颈部未见明显不适,肿块明显缩小,彩超示:右侧叶较大低回声结节约5.6×3.7mm、左侧叶较大者2.8×1.7 mm、颈部淋巴结较大者3.3×2.5mm。
病例2:刘某,女性,41岁,平素脾气急躁、易怒,半年前于当地医院检查,彩超提示甲状腺肿大,未查甲功,建议定期复查,未予治疗;1月前自觉颈部不适,平素恶寒,善太息,大便可,小便黄,舌质红,舌体胖大,苔薄黄,脉沉弦;辅助检查:甲功提示TSH轻微升高,FT3、FT4未见明显异常,彩超:右侧叶可见数个低回声结节,较大者范围约22.1×10.5mm,低回声不均质结节,边界清,回声不均与,CDFI:血流信号丰富;细针穿刺排除甲状腺癌;甲状腺Ⅲ度肿大,质硬;诊断为“甲状腺肿瘤”。外敷本发明中药膏治疗3个疗程后,颈部不适症状减轻,肿块明显减小;11个疗程后,颈部偶伴不适,彩超:右侧叶较大结节者范围约10.1×4.7mm。
病例3:张某,男性,38岁,1月前单位体检,发现甲状腺结节,未见其他明显不适,未予治疗;1周前自觉颈部明显不适,偶伴吞咽困难,脾气急躁,纳眠可,二便调;甲状腺触诊:甲状腺Ⅱ度肿大,质韧;辅助检查:甲功未见明显异常,彩超示左侧叶可见数个低回声结节,较大者范围约13.1×7.6mm,低回声不均质结节,边界清内回声不均匀,CDFI:血流信号丰富;细针穿刺排除甲状腺癌;诊断为“甲状腺肿瘤”。外敷本发明中药膏治疗5个疗程后,吞咽困难症状明显缓解,颈部肿块变软;12个疗程后,颈部未见明显不适,彩超示左侧叶较大结节范围约3.7×3.4mm。
病例4:孙某,女性,43岁,甲状腺肿大4年余,至多家医院就诊,彩超提示肿块体积较大,甲功基本正常,细针穿刺符合甲状腺肿瘤病理诊断;诊断为“甲状腺肿瘤”,建议手术治疗,患者拒绝,为求保守治疗,来我院门诊治疗;颈部明显不适,按压明显,恶寒,脾气急躁,乏力,纳食一般,睡眠可,大便可,小便黄;舌质红,苔黄腻,脉弦;触诊:甲状腺Ⅱ度肿大,质硬,压痛。外敷本发明中药膏治疗6个疗程后,肿块明显减小,症状改善较明显;12个疗程后,肿块减小1/2,临床症状明显好转。
病例5:丁某,女,37岁,诊断为“单纯甲状腺肿”7年余,定期观察,未予特殊处理,3月前自觉肿块变大,行彩超检查:彩超示右侧叶可见数个低回声结节,较大者范围约18.3×9.3mm,低回声不均质结节,边界清内回声不均与,CDFI:血流信号丰富;细针穿刺排除甲状腺癌。现症见:颈部不适,偶伴头晕、头蒙,平素脾气急躁,纳食可,眠差,二便调,脉弦细。外敷本发明中药膏治疗5个疗程后,肿块减小,临床症状缓解;12个疗程后,肿块明显减小,彩超示较大结节范围约6.7×2.8mm,颈部未见明显不适。
(七)、结论
本发明针对甲状腺肿瘤气滞、痰凝、血瘀的基本病机,具有行气活血、化痰软坚、消瘿散结之功效,能够减小颈部肿块、缓解症状、缩短病程,是用于改善甲状腺肿瘤的有效药物,有效率达86.0%,无毒副作用,疗效稳定,安全可靠,是治疗甲状腺肿瘤药物上的创新,经济和社会效益显著。
Claims (5)
1.一种治疗甲状腺肿瘤的中药膏,其特征在于,该中药膏由重量计的:海藻20-30g、昆布20-30g、青皮10-20g、陈皮20-30g、连翘20-30g、猫爪草10-20g、蜂房10-20g、乳香10-20g、没药10-20g、莪术10-20g、浙贝母10-20g、川芎20-30g、当归20-30g、甘草15-20g、独活10-15g、半夏10-20g、夏枯草20-30g、牡蛎20-30g、海蛤壳20-30g、黄药子10-15g、柴胡15-30g、合欢皮10-20g、鬼箭羽10-20g、冰片10-20g、穿山龙10-30g和蜂蜜10-20g制成,将上述除蜂蜜外的药物研成粉末,将蜂蜜与粉末混合在一起,加开水搅拌,直至变成均匀的药糊,即成。
2.根据权利要求1所述的一种治疗甲状腺肿瘤的中药膏,其特征在于,该中药膏由重量计的:海藻23-27g、昆布23-27g、青皮13-17g、陈皮23-27g、连翘23-27g、猫爪草13-17g、蜂房13-17g、乳香13-17g、没药13-17g、莪术13-17g、浙贝母13-17g、川芎23-27g、当归23-27g、甘草16-18g、独活11-13g、半夏13-17g、夏枯草23-27g、牡蛎23-27g、海蛤壳23-27g、黄药子11-13g、柴胡20-25g、合欢皮13-17g、鬼箭羽13-17g、冰片13-17g、穿山龙15-25g和蜂蜜13-17g制成。
3.根据权利要求1所述的一种治疗甲状腺肿瘤的中药膏,其特征在于,该中药膏由重量计的:海藻30g、昆布30g、青皮20g、陈皮30g、连翘30g、猫爪草20g、蜂房20g、乳香20g、没药20g、莪术20g、浙贝母20g、川芎30g、当归30g、甘草20g、独活15g、半夏20g、夏枯草30g、牡蛎30g、海蛤壳30g、黄药子15g、柴胡30g、合欢皮20g、鬼箭羽20g、冰片20g、穿山龙30g和蜂蜜20g制成。
4.根据权利要求1所述的一种治疗甲状腺肿瘤的中药膏,其特征在于,该中药膏由重量计的:海藻25g、昆布25g、青皮15g、陈皮25g、连翘25g、猫爪草15g、蜂房15g、乳香15g、没药15g、莪术15g、浙贝母15g、川芎25g、当归25g、甘草17g、独活12g、半夏15g、夏枯草25g、牡蛎25g、海蛤壳25g、黄药子12g、柴胡22g、合欢皮15g、鬼箭羽15g、冰片15g、穿山龙20g和蜂蜜15g制成。
5.根据权利要求1所述的一种治疗甲状腺肿瘤的中药膏,其特征在于,该中药膏由重量计的:海藻20g、昆布20g、青皮10g、陈皮20g、连翘20g、猫爪草10g、蜂房10g、乳香10g、没药10g、莪术10g、浙贝母10g、川芎20g、当归20g、甘草15g、独活10g、半夏10g、夏枯草20g、牡蛎20g、海蛤壳20g、黄药子10g、柴胡15g、合欢皮10g、鬼箭羽10g、冰片10g、穿山龙10g和蜂蜜10g制成。
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