CN108853412A - A kind of spray preparation method and applications for treating cervical vertebra, lumbar vertebra disease - Google Patents
A kind of spray preparation method and applications for treating cervical vertebra, lumbar vertebra disease Download PDFInfo
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Classifications
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- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/232—Angelica
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- A61K35/56—Materials from animals other than mammals
- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
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- A61K35/56—Materials from animals other than mammals
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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Abstract
The invention belongs to technical field of traditional Chinese medicines, especially a kind of spray preparation method and applications for treating cervical vertebra, lumbar vertebra disease, it is adjusted by the dosage to each herbal medicine, and the processing mode of decoction, ultrasonic extraction is respectively adopted, effective component in drug is sufficiently leached, and the regulation of combined process parameter, so that the pharmacological property of drug is improved, and then drug is strengthened to the therapeutic effect of lumbar vertebrae, cervical spondylosis, furthermore, for the treatment of rheumatic arthritis, effect especially proposes that cure rate reaches 90% or more.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, especially it is a kind of treat cervical vertebra, lumbar vertebra disease spray preparation method and its
Using.
Background technique
With industrial society, information and network times, the contact in intelligent epoch and arrive, the movement of the mankind is fewer and fewer, mostly
The number time all works or entertains before TV, computer, mobile phone, then strength vertebra disease, scapulohumeral periarthritis, osteoproliferation, prolapse of lumbar intervertebral disc etc.
Disease is emerged in large numbers in blowout, brings the inconvenience and pain of extreme to human work and life, how to allow the rehabilitation as early as possible of these sufferers,
It is the main target of this invention.
And vina is China's conventional medicament dosage form, is had a long history, but its carrying or inconvenient to use；Therefore, it is
The dosage form for enriching the drug promotes the competitiveness of Products, and company develops a kind of new spray, which can be straight
It being connected to up to site of action, when administration and medicine-feeding part is without direct mechanical friction, thus reduce the damage or stimulation to skin,
With easy to use, absorb it is fast, it is spraying uniform the advantages that.
Summary of the invention
In order to solve the above technical problems existing in the prior art, cervical vertebra, lumbar vertebra disease are treated the present invention provides a kind of
Spray preparation method and applications.
It is realized especially by following manner.
A kind of spray preparation method for treating cervical vertebra, lumbar vertebra disease, including following step：
(1) after taking Radix Angelicae Sinensis, the root of Dahurain angelica, root of Chinese clematis mixing, 60~80 mesh are crushed to, 6~8 times of purified waters of its weight are added and decoct
60~90min after filtering, obtains filtrate A and filter residue, and 3~5 times of water of its weight are added in filter residue and decoct 30~60min, are filtered,
Liquor B is obtained, filtrate A and liquor B are merged, is condensed into medicinal extract under the conditions of 60~65 DEG C, it is dried, crushed into 100~
120 mesh powders；
(2) following raw material is taken：5~10 parts of Fructus Liquidambaris, 5~10 parts of big bar, 10~15 parts of ginseng, Radix Notoginseng 10~15
Part, 3~6 parts of leech, 5~10 parts of asarum, 5~10 parts of the shell of areca nut, tiger urine 2~5 parts, 1~5 part of ant, 1~5 part of pheretima, small blood
1~5 part of rattan, 5~10 parts of Radix Glycyrrhizae, after mixing, are crushed to 60~80 mesh, and after mixing plus extractant adjustment solid-liquid ratio is 1：(4~
6) 30~60min, is impregnated, 45~60min is extracted under the conditions of ultrasonic power is 50~100W, extracts 2 times, must extract respectively
Liquid；
(3) step (1) powder is added in step (2) extracting solution, high-speed stirred is uniform, in 70~80 DEG C of high-temperature process
2~3h is added the auxiliary material of its quality 5~10%, is filled to spray bottle after cooling.
The Radix Angelicae Sinensis, the root of Dahurain angelica, the root of Chinese clematis mass ratio be 2：2：1.
The mass ratio of step (1) powder and extracting solution is 0.2~0.4：1.
The extractant is 3 according to volume ratio by ethyl alcohol and glycerine：1.2~1.6 mix.
The auxiliary material is 1,2-PD, 1,3-PD, azone according to (10~20)：(5~10)：The weight of (1~5)
Proportion mixes.
In step (2) soaking process, the complex enzyme of raw material weight 1~3% in the step is added, the complex enzyme is
Cellulase, pectase, papain.
The cellulase, pectase, wooden pipe protease weight ratio be 2：1：0.5.
Application of the spray of above method preparation in treatment cervical vertebra, lumbar vertebrae medicine.
Beneficial effect
The present invention is adjusted by the dosage to each herbal medicine, and the processing side of decoction, ultrasonic extraction is respectively adopted
Formula enables the effective component in drug sufficiently to leach, and the regulation of combined process parameter, so that the pharmacological property of drug is changed
It is kind, and then drug is strengthened to the therapeutic effect of lumbar vertebrae, cervical spondylosis, in addition, being directed to the treatment of rheumatic arthritis, effect is especially
It proposes, cure rate reaches 90% or more.
The present invention improves at least 10% or more compared to traditional vina, for the cure rate of cervical spondylosis and lumbar vertebra disease, reduces
Damage or stimulation to skin, have it is easy to use, absorb it is fast, it is spraying uniform the advantages that.
The present invention especially selects 1,2-PD, 1,3-PD, azone as auxiliary material, can cooperate with and improve drug
In the skin of effective component infiltration, to play drug effect ahead of time.
Specific embodiment
Tuberculosis specific embodiment is limited technical solution of the present invention is further below, but claimed
Range is not only limited to made description.
Embodiment 1
A kind of spray preparation method for treating cervical vertebra, lumbar vertebra disease, including following step：
(1) after taking Radix Angelicae Sinensis, the root of Dahurain angelica, root of Chinese clematis mixing, 60 mesh are crushed to, 6 times of purified waters of its weight are added and decoct 60min,
After filtering, filtrate A and filter residue are obtained, 3 times of water of its weight are added in filter residue and decoct 30min, filtering obtains liquor B, by filtrate A
It is merged with liquor B, is condensed into medicinal extract under the conditions of 60 DEG C, be dried, crushed into 100 mesh powders；
(2) following raw material is taken：It is Fructus Liquidambaris 5g, big bar 5g, ginseng 10g, Radix Notoginseng 10g, leech 3g, asarum 5g, big
Abdomen skin 5g, tiger urine 2g, ant 1g, pheretima 1g, yellow angledtwig magnoliavine root stem and leaf 1g, Radix Glycyrrhizae 5g, after mixing, are crushed to 60 mesh, extractant are added after mixing
Adjusting solid-liquid ratio is 1：4,30min is impregnated, 45min is extracted under the conditions of ultrasonic power is 50W, extracts 2 times, must extract respectively
Liquid；
(3) step (1) powder being added in step (2) extracting solution, high-speed stirred is uniform, in 70 DEG C of high-temperature process 2h,
The auxiliary material of its quality 5~10% is added after cooling, is filled to spray bottle.
The Radix Angelicae Sinensis, the root of Dahurain angelica, the root of Chinese clematis mass ratio be 2：2：1.
The mass ratio of step (1) powder and extracting solution is 0.2：1.
The extractant is 3 according to volume ratio by ethyl alcohol and glycerine：1.2 mixing.
The auxiliary material is 1,2-PD, 1,3-PD, azone according to 10：5：1 weight proportion mixes.
Embodiment 2
A kind of spray preparation method for treating cervical vertebra, lumbar vertebra disease, including following step：
(1) after taking Radix Angelicae Sinensis, the root of Dahurain angelica, root of Chinese clematis mixing, 80 mesh are crushed to, 8 times of purified waters of its weight are added and decoct 90min,
After filtering, filtrate A and filter residue are obtained, 5 times of water of its weight are added in filter residue and decoct 60min, filtering obtains liquor B, by filtrate A
It is merged with liquor B, is condensed into medicinal extract under the conditions of 65 DEG C, be dried, crushed into 120 mesh powders；
(2) following raw material is taken：Fructus Liquidambaris 10g, big bar 10g, ginseng 15g, Radix Notoginseng 15g, leech 6g, asarum 10g,
Shell of areca nut 10g, tiger urine 5g, ant 5g, pheretima 5g, yellow angledtwig magnoliavine root stem and leaf 5g, Radix Glycyrrhizae 10g, after mixing, are crushed to 80 mesh, after mixing plus mention
Taking agent adjustment solid-liquid ratio is 1：6,60min is impregnated, 60min is extracted under the conditions of ultrasonic power is 100W, extracts 2 times, obtain respectively
Extracting solution；
(3) step (1) powder being added in step (2) extracting solution, high-speed stirred is uniform, in 80 DEG C of high-temperature process 3h,
The auxiliary material of its quality 10% is added after cooling, is filled to spray bottle.
The Radix Angelicae Sinensis, the root of Dahurain angelica, the root of Chinese clematis mass ratio be 2：2：1.
The mass ratio of step (1) powder and extracting solution is 0.4：1.
The extractant is 3 according to volume ratio by ethyl alcohol and glycerine：1.6 mixing.
The auxiliary material is 1,2-PD, 1,3-PD, azone according to 20：10：5 weight proportion mixes.
Embodiment 3
A kind of spray preparation method for treating cervical vertebra, lumbar vertebra disease, including following step：
(1) after taking Radix Angelicae Sinensis, the root of Dahurain angelica, root of Chinese clematis mixing, 70 mesh are crushed to, 7 times of purified waters of its weight are added and decoct 75min,
After filtering, filtrate A and filter residue are obtained, 4 times of water of its weight are added in filter residue and decoct 45min, filtering obtains liquor B, by filtrate A
It is merged with liquor B, is condensed into medicinal extract under the conditions of 63 DEG C, be dried, crushed into 100 mesh powders；
(2) following raw material is taken：It is Fructus Liquidambaris 10g, big bar 5g, ginseng 15g, Radix Notoginseng 10g, leech 3g, asarum 5g, big
Abdomen skin 10g, tiger urine 5g, ant 1g, pheretima 5g, yellow angledtwig magnoliavine root stem and leaf 1g, Radix Glycyrrhizae 10g, after mixing, are crushed to 70 mesh, after mixing plus extract
It is 1 that agent, which adjusts solid-liquid ratio,：6,45min is impregnated, 60min is extracted under the conditions of ultrasonic power is 80W, extracts 2 times, must extract respectively
Liquid；
(3) step (1) powder is added in step (2) extracting solution, high-speed stirred is uniform, in 75 DEG C of high-temperature process
2.5h is added the auxiliary material of its quality 8%, is filled to spray bottle after cooling.
The Radix Angelicae Sinensis, the root of Dahurain angelica, the root of Chinese clematis mass ratio be 2：2：1.
The mass ratio of step (1) powder and extracting solution is 0.3：1.
The extractant is 3 according to volume ratio by ethyl alcohol and glycerine：1.4 mixing.
The auxiliary material is 1,2-PD, 1,3-PD, azone according to 14：8：3 weight proportion mixes.
Embodiment 4
A kind of spray preparation method for treating cervical vertebra, lumbar vertebra disease, including following step：
(1) after taking Radix Angelicae Sinensis, the root of Dahurain angelica, root of Chinese clematis mixing, 80 mesh are crushed to, 6 times of purified waters of its weight are added and decoct 60min,
After filtering, filtrate A and filter residue are obtained, 5 times of water of its weight are added in filter residue and decoct 60min, filtering obtains liquor B, by filtrate A
It is merged with liquor B, is condensed into medicinal extract under the conditions of 62 DEG C, be dried, crushed into 100 mesh powders；
(2) following raw material is taken：Fructus Liquidambaris 8g, big bar 6g, ginseng 12g, Radix Notoginseng 14g, leech 5g, asarum 7g,
Shell of areca nut 7g, tiger urine 4g, ant 4g, pheretima 4g, yellow angledtwig magnoliavine root stem and leaf 2g, Radix Glycyrrhizae 6g, after mixing, are crushed to 80 mesh, after mixing plus extract
It is 1 that agent, which adjusts solid-liquid ratio,：4,30min is impregnated, 60min is extracted under the conditions of ultrasonic power is 60W, extracts 2 times, must extract respectively
Liquid；
(3) step (1) powder being added in step (2) extracting solution, high-speed stirred is uniform, in 78 DEG C of high-temperature process 3h,
The auxiliary material of its quality 6% is added after cooling, is filled to spray bottle.
The Radix Angelicae Sinensis, the root of Dahurain angelica, the root of Chinese clematis mass ratio be 2：2：1.
The mass ratio of step (1) powder and extracting solution is 0.3：1.
The extractant is 3 according to volume ratio by ethyl alcohol and glycerine：1.5 mixing.
The auxiliary material is 1,2-PD, 1,3-PD, azone according to 13：8：2 weight proportion mixes.
In step (2) soaking process, the complex enzyme of raw material weight 1% in the step is added, the complex enzyme is fibre
Tie up plain enzyme, pectase, papain.
The cellulase, pectase, wooden pipe protease weight ratio be 2：1：0.5.
Application of the spray of above method preparation in treatment cervical vertebra, lumbar vertebrae medicine.
The additive capacity of complex enzyme is 1% in above-mentioned steps (2), but in other examples, the additive of complex enzyme
Amount is 1~3%.
Test example 1
Select in March, 2015~2016 year March to the medical cervical spondylosis of my company and lumbar vertebrae patient, wherein 94 conducts
Research object is divided into study group 71 according to patient's the principle of voluntariness, and control group 23, two groups of patients show different degrees of waist
Portion's pain and cervical pain, wherein patient with cervical Spondylopathy with it is different degrees of swallow, vision disorder, lower limb walking disorder, it is dizzy,
The symptoms such as upper limb numbness, headache；Lumbar vertebrae patient is with the symptoms such as waist moving obstacle, numbness of lower limbs or pain, scoliosis；
Study group male suffers from 45, and female suffers from 26, and year is 30~45 years old, and control group male suffers from 12, and female suffers from 11, and the age is 28~50
Year；All patient's courses of disease are at 6 months or more；Wherein study group uses the spray of 1~4 scheme of embodiment of the present invention preparation
In affected part, every spray 2 times, mono- course for the treatment of of 7d treats 3 courses for the treatment of；Control group drug is smeared 2 times daily, mono- course for the treatment of of 7d, treatment
3 courses for the treatment of；Control group medicine preparation scheme is as follows：
Compare group of formula：Radix Angelicae Sinensis 24g, root of Dahurain angelica 24g, Fructus Liquidambaris 11g, big bar 13g, ginseng 12g, Radix Notoginseng 16g, leech 10g,
Root of Chinese clematis 10g, asarum 12g, shell of areca nut 9g, tiger urine 3g, ant 2g, pheretima 4g, yellow angledtwig magnoliavine root stem and leaf 13g, Radix Glycyrrhizae 12g.
The upper treatment cervical vertebra, lumbar vertebra disease Chinese medicine composition vina preparation method, include the following steps：
(1) each taste Chinese medicine is measured according to formula, the sweet potato wine that alcoholic strength is 32 ° is added after mixing and impregnates 20d, it is mixed to obtain liquid medicine
Close object；
(2) aperture is used to filter for 0.75 μm of film in liquid medicine mixture.
Clinical evaluation standard：1. curing：The relevant symptom of patient and sign disappear, and it is normal to check display, and can normally join
Processing is made；2. effective：Patient's related symptoms disappear substantially with sign, check lesions showed disappear not exclusively, suffer from cold or fatigue after
There is slight uncomfortable or pain；3. the clinical symptoms of effective patient are alleviated with sign, it is only capable of participating in slight work；4. nothing
Effect：Any improvement of object even aggravates；
Clinical effectiveness is as shown in table 1 below：
| Group | It cures | It is effective | Effectively | In vain | Cure rate % |
| Embodiment 1 | 13 | 2 | 1 | 0 | 81.3 |
| Embodiment 2 | 16 | 2 | 1 | 0 | 84.2 |
| Embodiment 3 | 16 | 1 | 1 | 0 | 88.9 |
| Embodiment 4 | 17 | 1 | 0 | 0 | 94.4 |
| Control group | 16 | 2 | 3 | 2 | 69.6 |
Therefore, although the present invention uses raw material identical with control group, it is not identical in proportion dosage, and needle
Not identical to the processing mode of every a herb, the present invention is exactly based on this improvement processing, so that the collaboration between drug
Effect is enhanced, so that drug gets a promotion to the therapeutic effect of cervical spondylosis and lumbar vertebra disease.
Test example 2
Select in March, 2015~2016 year March to my the medical rheumatoid arthritis patients of company, wherein 65 are used as and grind
Study carefully object, study group 36 is divided into according to patient's the principle of voluntariness, control group 29, study group male suffers from 17, and female suffers from 19, every year
It is 30~45 years old, control group male suffers from 15, and female suffers from 14, and the age is 30~45 years old；Two groups of patient ages, gender, the course of disease, joints
Functional classification and x-ray compare by stages, and indifference is significant, and two groups of cases are comparable；Wherein study group is implemented using the present invention
The spray of 1 scheme of example preparation treats 3 courses for the treatment of in affected part, every spray 2 times, mono- course for the treatment of of 7d；Control group 1 is using implementation
The identical drug of example 1, daily to smear 2 times, mono- course for the treatment of of 7d treats 3 courses for the treatment of,
As a result as shown in table 2 below：
| Group | Number of cases | It cures | Effectively | In vain | Cure rate % |
| Embodiment 1 | 36 | 33 | 2 | 1 | 91.7 |
| Control group 1 | 29 | 19 | 4 | 6 | 65.5 |
As seen from the results in Table 2, the spray of the present invention program preparation is to treatment rheumatic arthritis significant effect.
It is important to point out that, above embodiments and test example are only limitted to do further technical solution of the present invention herein
Elaboration and understanding, should not be understood as it is further to technical solution of the present invention limited, what those skilled in the art made
The innovation and creation of non-protruding essential characteristics and marked improvement still fall within protection category of the invention.
Claims (8)
1. a kind of spray preparation method for treating cervical vertebra, lumbar vertebra disease, which is characterized in that including following step：
(1) after taking Radix Angelicae Sinensis, the root of Dahurain angelica, root of Chinese clematis mixing, 60~80 mesh are crushed to, be added 6~8 times of purified waters of its weight decoct 60~
90min after filtering, obtains filtrate A and filter residue, and 3~5 times of water of its weight are added in filter residue and decoct 30~60min, filtering obtains
Liquor B merges filtrate A and liquor B, is condensed into medicinal extract under the conditions of 60~65 DEG C, is dried, crushed into 100~120 mesh
Powder；
(2) following raw material is taken：5~10 parts of Fructus Liquidambaris, 5~10 parts of big bar, 10~15 parts of ginseng, 10~15 parts of Radix Notoginseng,
3~6 parts of leech, 5~10 parts of asarum, 5~10 parts of the shell of areca nut, tiger urine 2~5 parts, 1~5 part of ant, 1~5 part of pheretima, yellow angledtwig magnoliavine root stem and leaf 1
~5 parts, 5~10 parts of Radix Glycyrrhizae, after mixing, are crushed to 60~80 mesh, and after mixing plus extractant adjustment solid-liquid ratio is 1：(4~6), leaching
30~60min is steeped, 45~60min is extracted under the conditions of ultrasonic power is 50~100W, extracts 2 times respectively, obtain extracting solution；
(3) step (1) powder is added in step (2) extracting solution, high-speed stirred is uniform, in 70~80 DEG C of high-temperature process 2~
3h is added the auxiliary material of its quality 5~10%, is filled to spray bottle after cooling.
2. the spray preparation method for the treatment of cervical vertebra, lumbar vertebra disease as described in claim 1, which is characterized in that the Radix Angelicae Sinensis, white
The root of Dahurian angelica, the root of Chinese clematis mass ratio be 2：2：1.
3. the spray preparation method for the treatment of cervical vertebra, lumbar vertebra disease as described in claim 1, which is characterized in that step (1) powder
The mass ratio of end and extracting solution is 0.2~0.4：1.
4. as described in claim 1 treatment cervical vertebra, lumbar vertebra disease spray preparation method, which is characterized in that the extractant by
Ethyl alcohol and glycerine are 3 according to volume ratio：1.2~1.6 mix.
5. the spray preparation method for the treatment of cervical vertebra, lumbar vertebra disease as described in claim 1, which is characterized in that the auxiliary material is 1,
2- propylene glycol, 1,3-PD, azone are according to (10~20)：(5~10)：The weight proportion of (1~5) mixes.
6. the spray preparation method for the treatment of cervical vertebra, lumbar vertebra disease as described in claim 1, which is characterized in that step (2) leaching
During bubble, the complex enzyme of raw material weight 1~3% in the step is added, the complex enzyme is cellulase, pectase, pawpaw
Protease.
7. the spray preparation method for the treatment of cervical vertebra, lumbar vertebra disease as claimed in claim 6, which is characterized in that the cellulase,
Pectase, wooden pipe protease weight ratio be 2：1：0.5.
8. such as spray the answering in treatment cervical vertebra, lumbar vertebrae medicine of method according to any one of claims 1 to 7 preparation
With.
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| CN104083428A (en) * | 2014-06-05 | 2014-10-08 | 王应江 | Medicine for treating rheumatism and lumbar disc protrusion and production method thereof |
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| CN104083428A (en) * | 2014-06-05 | 2014-10-08 | 王应江 | Medicine for treating rheumatism and lumbar disc protrusion and production method thereof |
| CN104225477A (en) * | 2014-09-25 | 2014-12-24 | 董伟 | Traditional Chinese medicine plaster for treating cervical vertebra disease and lumbar vertebra disease |
| CN106474444A (en) * | 2016-11-29 | 2017-03-08 | 佛山健翔医院有限公司 | A kind of external application Chinese medicine medicated bag formula, medicated bag and its using method |
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