CN108853225A - A kind of little Jin Chinese medicine compound prescription plastics and its preparation method and application - Google Patents
A kind of little Jin Chinese medicine compound prescription plastics and its preparation method and application Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/55—Glands not provided for in groups A61K35/22 - A61K35/545, e.g. thyroids, parathyroids or pineal glands
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/24—Mucus; Mucous glands; Bursa; Synovial fluid; Arthral fluid; Excreta; Spinal fluid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/62—Leeches; Worms, e.g. cestodes, tapeworms, nematodes, roundworms, earth worms, ascarids, filarias, hookworms, trichinella or taenia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
Abstract
A kind of little Jin Chinese medicine compound prescription plastics, it is prepared by little Jin extract, filmogen, plasticizer, skin penetration enhancer, organic solvent and water, and the weight proportion of supplementary material is：20~50 parts of little Jin extract, 10~20 parts of filmogen, 4~12 parts of plasticizer, 0.1~5 part of transdermal penetration agent, 30~50 parts of organic solvent；Wherein, the little Jin extract is prepared by following weight proportion bulk pharmaceutical chemicals：20~40 parts of Moschus, 130~170 parts of wild aconite root, 130~170 parts of semen momordicae, 130~170 parts of resina liquidamberis, 130~170 parts of pheretima, 130~170 parts of excrementum pteropi, 65~85 parts of olibanum, 65~85 parts of myrrh, 65~85 parts of Radix Angelicae Sinensis, 8~16 parts of capital ink.The present invention also provides the preparation method of the plastics and purposes.Little Jin Chinese medicine compound prescription plastics of the present invention, percutaneous dosing is rapid-action, can be in lesion part, fast onset anti-inflammatory and analgesic effect, and drugloading rate is big, transdermal effect is good, non-stimulated to skin.
Description
Technical field
The present invention relates to a kind of little Jin Chinese medicine compound prescription plastics.
Background technique
Xiaojin pill is first recorded in Qing Dynasty's Wang Hongxu《Surgery card controls Quan Shengji》, by Moschus, wild aconite root, semen momordicae, resina liquidamberis,
Totally 10 taste medicines form for dragon, excrementum pteropi, olibanum, myrrh, Radix Angelicae Sinensis, capital ink, and formula is proper, significant in efficacy, easy to use.Effect dissipating bind
Detumescence, blood-activating analgetic.For treating the cards such as scrofula, goiter, mammary cancer, breast illness caused by mental disorder stagnates, mammary gland disease effect is treated
It is further preferred that.Pertinent literature shows that xiaojin pill can be used for neoplastic diseases, and terpene contained therein, alkaloid and polysaccharide can induce tumour
Apoptosis adjusts MAPK access, inhibits the expression of relevant inflammatory factors and the increase of tumor microvessel density.Experiment shows
Xiaojin pill has bacteriostasis to staphylococcus aureus, Escherichia coli, hemolytic streptococcus, Neisseria etc..Little Jin simultaneously
Ball can improve state of blood stasis and inhibit tumour growth, and Small side effects work rapidly, persistent.Disappear in addition, xiaojin pill also has
Inflammation, detumescence, treating tuberculosis, sedation-analgesia and the effect for improving immunity of organisms and disease resistance, can promote lump and scar to subtract
Light or recession.Xiaojin pill wide indications.Clinically xiaojin pill is usually used in thyroid adenoma, thyroid cyst, multifocal neurological at present
Fibroma, lymphosarcoma, lipoma, bone tumour, breast cancer, gastric cancer, lung cancer, thymus gland abdominal cavity inflammatory mass and abscess, band-like blister
The early stage etc. of the diseases such as rash, Acne conglobata, mastofibroma, intestinal tuberculosis, tuberculosis of bone and joint.The above disease typically exhibits
Often there is swollen, pain inflammatory performance in the swollen pathological characters having a pain firmly, part.It is obvious for anti-inflammatory Western medicine side effect.Traditional Chinese medicine
There is significant in efficacy, the advantage of Small side effects in terms for the treatment of such disease.And xiaojin pill safety and low toxicity, treating both manifestation and root cause of disease, extensively
It is welcome by patient.
However xiaojin pill is beaten powder and is used as medicine using primary crude drug, need to be smashed when taking, it is inconvenient to use, and cannot directly act on
It breaks out and uses in lesion, it is difficult to reach the therapeutic effect of rapid relief of symptoms.
Application number：201810489870.8 denomination of invention：A kind of little Jin rubber emplastrum and preparation method thereof and purposes, should
A kind of little Jin rubber emplastrum of disclosure of the invention is made of the supplementary material that following weight matches：6~7 parts of little Jin extract, natural rubber
30~80 parts of glue, 40~60 parts of tackifier, 20~45 parts of softening agent, 50~120 parts of filler.The invention also discloses above-mentioned small
Purposes of the golden rubber emplastrum in the drug that the proliferation of mammary gland, breast cancer, thyroid nodule, thyroid cancer are treated in preparation.The invention
Little Jin rubber emplastrum there is production and processing smoothly Painting effect be good, cream face smoothness is good (exquisiteness without blank spot), paste performance
The advantages that excellent, stability is good, and removing is suitable for.
Currently, it is not yet reported that the purposes in the external drug of xiaojin pill externally treating herpes zoster is not more reported
Xiaojin pill raw material is prepared into plastics.
Summary of the invention
The technical solution of the present invention is to provide a kind of little Jin Chinese medicine compound prescription plastics.Another technical solution of the invention is
Provide the preparation method and purposes of the plastics.
The present invention provides a kind of little Jin Chinese medicine compound prescription plastics, it is by little Jin extract, filmogen, plasticizer, thoroughly
Skin sorbefacient, organic solvent and water are prepared, and the weight proportion of supplementary material is：
20~50 parts of little Jin extract, 10~20 parts of filmogen, 4~12 parts of plasticizer, 0.1~5 part of transdermal penetration agent,
30~50 parts of organic solvent；
Wherein, the little Jin extract is prepared by following weight proportion bulk pharmaceutical chemicals：
20~40 parts of Moschus, 130~170 parts of wild aconite root, 130~170 parts of semen momordicae, 130~170 parts of resina liquidamberis, pheretima
130~170 parts, 130~170 parts of excrementum pteropi, 65~85 parts of olibanum, 65~85 parts of myrrh, 65~85 parts of Radix Angelicae Sinensis, capital ink 8~16
Part.
It is further preferred that it by following weight match supplementary material at：
25~45 parts of little Jin extract, 12~20 parts of filmogen, 5~10 parts of plasticizer, 0.1~4 part of transdermal penetration agent,
35~45 parts of organic solvent.
It is further preferred that it by following weight match supplementary material at：
30~40 parts of little Jin extract, 14~18 parts of filmogen, 6~9 parts of plasticizer, 0.2~4 part of transdermal penetration agent,
37~43 parts of organic solvent.
It is further preferred that it by following weight match supplementary material at：
35 parts of little Jin extract, 15 parts of filmogen, 7 parts of plasticizer, 1 part of transdermal penetration agent, 42 parts of organic solvent system；
Wherein, the little Jin extract is prepared by following weight proportion bulk pharmaceutical chemicals：
30 parts of Moschus, 150 parts of wild aconite root, 150 parts of semen momordicae, 150 parts of resina liquidamberis, 150 parts of pheretima, 150 parts of excrementum pteropi, cream
12 parts of 75 parts fragrant, 75 parts of myrrh, 75 parts of Radix Angelicae Sinensis and capital ink.
Wherein, the extract is ethanol extract.
Wherein, the extract is to use 40% ethanol water to carry out as solvent by aforementioned weight proportion medicinal material
Extraction, solid-liquid ratio 1:12, extraction time 3h, medicinal extract relative density are 1.1.
Wherein, the filmogen includes the composition of one or more of bletilla glue, chitosan, polyvinyl alcohol；It is excellent
Selection of land, the filmogen are polyvinyl alcohol；；The polyvinyl alcohol is selected from polyvinyl alcohol 05-88, polyvinyl alcohol 17-88, poly- second
One or more of enol 124；
The plasticizer includes one or more of glycerol, propylene glycol, polyethylene glycol composition；Preferably, the increasing
Modeling agent is glycerol；
The transdermal penetration agent includes：One or more of azone, borneol, oleic acid composition；Preferably, the skin seeps
Saturating agent is the composition of azone and borneol；
The organic solvent includes one or more of acetone, ethyl alcohol, phenol composition；Preferably, described organic molten
Agent is ethyl alcohol.
It is further preferred that the polyvinyl alcohol is polyvinyl alcohol 124；Azone and borneol in the transdermal penetration agent
Portfolio ratio be 2：3~2:1；Preferably, the portfolio ratio of the composition azone and borneol is 1:1.
The feature that the features described above or embodiment that the present invention mentions are mentioned can be in any combination.Patent specification is taken off
All features shown can be used in combination with any composition form, and each feature disclosed in specification can be can provide by any
The alternative characteristics of identical, impartial or similar purpose replace.Therefore except there is special instruction, revealed feature is only impartial or phase
Like the general example of feature.
The present invention also provides the preparation methods of the xiaojin pill Chinese medicine compound prescription plastics, it includes the following steps：
(1) polyvinyl alcohol and sodium carboxymethylcellulose are dipped to expansion with suitable purified water respectively, are placed in water-bath
It is heated to being completely dissolved, matrix is used as after then mixing the two；
(2) little Jin extract is dissolved with ethanol solution, is added in the matrix under constant stirring, and in water-bath
Heating is stirred to no alcohol taste, is then cooled to room temperature；
(3) borneol, azone are mixed with glycerol and grind even, entered in the solution that step (2) obtains, ethyl alcohol is added, stirs evenly,
Up to the little Jin Chinese medicine compound prescription plastics.
Preparation method of the invention is better dispersed in active constituent in pharmaceutical preparation, can be fine with remaining each component
Ground fusion, obtained preparation are more favorable for absorption of human body, and preparation method is simple, without harsh reaction condition.
The present invention also provides purposes of the plastics in preparation treatment shingles medications.
The present invention also provides use of the plastics in preparation adjuvant treatment thyroid gland nodule, proliferation of mammary gland drug
On the way.
Little Jin Chinese medicine compound prescription plastics of the present invention, percutaneous dosing is rapid-action, can be in lesion part, fast onset anti-inflammatory and antalgic
Effect, and drugloading rate is big, transdermal effect is good, non-stimulated to skin.
Obviously, above content according to the present invention is not being departed from according to the ordinary technical knowledge and customary means of this field
Under the premise of the above-mentioned basic fundamental thought of the present invention, the modification, replacement or change of other diversified forms can also be made.
The specific embodiment of form by the following examples remakes further specifically above content of the invention
It is bright.But the range that this should not be interpreted as to the above-mentioned theme of the present invention is only limitted to example below.It is all to be based on above content of the present invention
The technology realized all belongs to the scope of the present invention.
Specific embodiment
It include 30 parts of Moschus, 150 parts of wild aconite root, 150 parts of semen momordicae, maple in little Jin extract in the embodiment of the present invention
150 parts of face cream, 150 parts of pheretima, 150 parts of excrementum pteropi, 75 parts of olibanum, 75 parts of myrrh, 75 parts of Radix Angelicae Sinensis, 12 parts of capital ink.
The preparation of the little Jin Chinese medicine compound prescription plastics of the present invention of embodiment 1
1. the preparation of little Jin extract
By 30 parts of Moschus, 150 parts of wild aconite root, 150 parts of semen momordicae, 150 parts of resina liquidamberis, 150 parts of pheretima, 150 parts of excrementum pteropi,
75 parts of olibanum, 75 parts of myrrh, 75 parts of Radix Angelicae Sinensis, the black 12 parts of use in capital
30% ethanol water is extracted as solvent, solid-liquid ratio 1:10, extraction time 2h collect filtrate,
It is concentrated into the medicinal extract that relative density is 1.1.
2. weighing supplementary material
3. the preparation of little Jin Chinese medicine compound prescription plastics
(1) polyvinyl alcohol and sodium carboxymethylcellulose are dipped to expansion with suitable purified water respectively, are placed in water-bath
It is heated to being completely dissolved, matrix is used as after then mixing the two；
(2) little Jin extract is dissolved with ethanol solution and is added in the matrix under constant stirring, and in water-bath
Heating is stirred to no alcohol taste, is then cooled to room temperature；
(3) borneol, azone are mixed with glycerol and grind even, entered in the solution that step (2) obtains, ethyl alcohol is added, stirs evenly,
Up to the little Jin Chinese medicine compound prescription plastics.
The preparation of the little Jin Chinese medicine compound prescription plastics of the present invention of embodiment 2
1. the preparation of little Jin extract
By 30 parts of Moschus, 150 parts of wild aconite root, 150 parts of semen momordicae, 150 parts of resina liquidamberis, 150 parts of pheretima, 150 parts of excrementum pteropi,
75 parts of olibanum, 75 parts of myrrh, 75 parts of Radix Angelicae Sinensis, 12 parts of capital ink use 35% ethanol water to be extracted as solvent, solid-liquid ratio
It is 1:11, extraction time 2h collect filtrate, are concentrated into the medicinal extract that relative density is 1.1.
2. weighing supplementary material
3. the preparation of little Jin Chinese medicine compound prescription plastics
(1) polyvinyl alcohol and sodium carboxymethylcellulose are dipped to expansion with suitable purified water respectively, are placed in water-bath
It is heated to being completely dissolved, matrix is used as after then mixing the two；
(2) little Jin extract is dissolved with ethanol solution and is added in the matrix under constant stirring, and in water-bath
Heating is stirred to no alcohol taste, is then cooled to room temperature；
(3) borneol, azone are mixed with glycerol and grind even, entered in the solution that step (2) obtains, ethyl alcohol is added, stirs evenly,
Up to the little Jin Chinese medicine compound prescription plastics.
The preparation of the little Jin Chinese medicine compound prescription plastics of the present invention of embodiment 3
1. the preparation of little Jin extract
By 30 parts of Moschus, 150 parts of wild aconite root, 150 parts of semen momordicae, 150 parts of resina liquidamberis, 150 parts of pheretima, 150 parts of excrementum pteropi,
75 parts of olibanum, 75 parts of myrrh, 75 parts of Radix Angelicae Sinensis, 12 parts of capital ink use 40% ethanol water to be extracted as solvent, solid-liquid ratio
It is 1:12, extraction time 3h collect filtrate, are concentrated into the medicinal extract that relative density is 1.1.
2. weighing supplementary material
3. the preparation of little Jin Chinese medicine compound prescription plastics
(1) polyvinyl alcohol and sodium carboxymethylcellulose are dipped to expansion with suitable purified water respectively, are placed in water-bath
It is heated to being completely dissolved, matrix is used as after then mixing the two；
(2) little Jin extract is dissolved with ethanol solution, is added in the matrix under constant stirring, and in water-bath
Heating is stirred to no alcohol taste, is then cooled to room temperature；
(3) borneol, azone are mixed with glycerol and grind even, entered in the solution that step (2) obtains, ethyl alcohol is added, stirs evenly,
Up to the little Jin Chinese medicine compound prescription plastics.
The preparation of the little Jin Chinese medicine compound prescription plastics of the present invention of embodiment 4
1. the preparation of little Jin extract
By 30 parts of Moschus, 150 parts of wild aconite root, 150 parts of semen momordicae, 150 parts of resina liquidamberis, 150 parts of pheretima, 150 parts of excrementum pteropi,
75 parts of olibanum, 75 parts of myrrh, 75 parts of Radix Angelicae Sinensis, 12 parts of capital ink use 45% ethanol water to be extracted as solvent, solid-liquid ratio
It is 1:12, extraction time 4h collect filtrate, are concentrated into the medicinal extract that relative density is 1.1.
2. weighing supplementary material
3. the preparation of little Jin Chinese medicine compound prescription plastics
(1) polyvinyl alcohol and sodium carboxymethylcellulose are dipped to expansion with suitable purified water respectively, are placed in water-bath
It is heated to being completely dissolved, matrix is used as after then mixing the two；
(2) little Jin extract is dissolved with ethanol solution, is added in the matrix under constant stirring, and in water-bath
Heating is stirred to no alcohol taste, is then cooled to room temperature；
(3) borneol, azone are mixed with glycerol and grind even, entered in the solution that step (2) obtains, ethyl alcohol is added, stirs evenly,
Up to the little Jin Chinese medicine compound prescription plastics.
The preparation of the little Jin Chinese medicine compound prescription plastics of the present invention of embodiment 5
1. the preparation of little Jin extract
By 30 parts of Moschus, 150 parts of wild aconite root, 150 parts of semen momordicae, 150 parts of resina liquidamberis, 150 parts of pheretima, 150 parts of excrementum pteropi,
75 parts of olibanum, 75 parts of myrrh, 75 parts of Radix Angelicae Sinensis, 12 parts of capital ink use 50% ethanol water to be extracted as solvent, solid-liquid ratio
It is 1:14, extraction time 3h collect filtrate, are concentrated into the medicinal extract that relative density is 1.1.
2. weighing supplementary material
3. the preparation of little Jin Chinese medicine compound prescription plastics
(1) polyvinyl alcohol and sodium carboxymethylcellulose are dipped to expansion with suitable purified water respectively, are placed in water-bath
It is heated to being completely dissolved, matrix is used as after then mixing the two；
(2) little Jin extract is dissolved with ethanol solution, is added in the matrix under constant stirring, and in water-bath
Heating is stirred to no alcohol taste, is then cooled to room temperature；
(3) borneol, azone are mixed with glycerol and grind even, entered in the solution that step (2) obtains, ethyl alcohol is added, stirs evenly,
Up to the little Jin Chinese medicine compound prescription plastics.
Clinical efficacy of the invention is verified below by test example：
1 present invention treatment shingles zoster clinical efficacy verification test of test example
1. experimental subjects
Patients with Herpes Zoster 60 are chosen, the age 45~70 years old, the course of disease 1~3 week, is randomly divided into two groups, every group of 30 people divide
It Wei not treatment group and control group.
2, medication
Treatment group：Little Jin Chinese medicine compound prescription plastics prepared by embodiment 1 are smeared outside treatment group affected part, daily in the morning, afternoon and evening each one
It is secondary, each 3ml (being equivalent to primary crude drug 0.9975g).One the course for the treatment of one week, continuously treat 2 courses for the treatment of.
Control group：Control group is given conventional western medicine and is treated, Cimetidine 0.2mg, persantine 25mg, indocin 25mg, often
Days 3 times are oral, one the course for the treatment of one week, 2 courses for the treatment of of continuous treatment.
3, therapeutic effect
Using average curative day and averagely analgesic number of days is foundation, and treatment results are as shown in table 1.
1 little Jin Chinese medicine compound prescription plastics of table treat herpes zoster group compared with control group curative effect
| Group | Number of cases | Average curative day | Averagely relieve pain number of days |
| Treatment group | 30 | 8.6 | 2.8 |
| Control group | 30 | 12.4 | 4 |
Experimental result explanation：Under the treatment of little Jin Chinese medicine compound prescription plastics of the present invention, shingles zoster is treated by treatment group
Average curative day is 8.6 days, and averagely analgesic number of days is 2.8 days；And it is 12.4 that control group routine of western medicine, which controls average curative day,
It, averagely analgesic number of days is 4 days.Illustrate little Jin Chinese medicine compound prescription plastics of the invention to the treatment of shingles zoster better than conventional west
Medicine treatment, can be used for the treatment of shingles zoster.
The adjuvant treatment of breast cancer of the present invention of test example 2 and thyroid cancer clinical efficacy verification test
1, subjects
Choose proliferation of mammary gland patient 200, the age 45~60 years old, the course of disease 9 months~2 years.It is randomly divided into two groups, every group
100 people, respectively test group and control group.Selection thyroid gland nodule patient 200, the age 38~55 years old, the course of disease 5 months~1
Year.Two groups are randomly divided into, every group of 100 people, respectively treatment group and control group.
2, medication
Treatment group：While carrying out corresponding disease conventional therapy, smeared in little Jin prepared by embodiment 1 outside treatment group affected part
Medicine compound plastics, each primary daily morning and evening, each 3ml (being equivalent to primary crude drug 0.9975g).One the course for the treatment of one month, even
2 courses for the treatment of of continuous treatment.
Control group：While carrying out corresponding disease conventional therapy, the sky for being free of little Jin extract is smeared outside control group affected part
White plastics, it is each primary daily morning and evening.One the course for the treatment of one month, continuously treat 2 courses for the treatment of.3, therapeutic effect
Using curative day as foundation, treatment results are as shown in table 2.
2 little Jin Chinese medicine compound prescription plastics of table assist in the treatment of the proliferation of mammary gland and thyroid gland nodule treatment group and control group curative effect ratio
Compared with
Experimental result explanation：Under the booster action of the plastics containing little Jin extract of the present invention, mammary gland is treated by treatment group
The average curative day of hyperplasia is 25 days, and the average curative day for the treatment of thyroid gland nodule is 28.6 days；And control group is without this
The auxiliary of invention plastics, the average curative day for treating the proliferation of mammary gland is 40.8 days, treats the average healing of thyroid gland nodule
Number of days is 49.2 days.The average curative day for the treatment of group is significantly faster than that control group, illustrates little Jin Chinese medicine compound prescription film of the invention
Agent can be used for the adjuvant treatment of the proliferation of mammary gland and thyroid gland nodule.
The quick anti-inflammatory and antalgic Curative effect experiment of the external medication of 3 present invention of test example
1, anti-inflammatory Curative effect experimental method
Take normal ICR mouse, 25~28g of weight, male.3 groups are randomly divided into, every group of 10 mouse.Blank mouse ear
The plastics for being free of little Jin extract are smeared on two sides, and the drug containing plastics of equivalent are smeared on little Jin plastics group mouse ear two sides
(prepared by embodiment 1), xiaojin pill group Mouse oral is converted into the same dose of xiaojin pill suspensions.After medication 1 hour, wash away
Plastics, two sides before and after being applied to the left front ear of mouse with 50 μ l dimethylbenzene, put to death mouse after causing inflammation 1h, cut a left side along auricle base line
Right two ears, remove round auricle, electronic balance weighing, with mouse or so auricular concha at same position respectively with punch (diameter 9mm)
The difference of weight calculates swelling percentage as auricular concha swelling degree.
Swelling percentage=(left auricular concha weight-auris dextra shell weight)/auris dextra shell weight * 100%
2, anti-inflammatory Curative effect experimental result
Experimental result is shown in Table 3.
The influence (mean ± S) of 3 little Jin Chinese medicine compound prescription plastics of table and xiaojin pill paraxylene induced mice ear swelling
Group Animals number (only) swelling rate (part)
The experimental results showed that ear swelling rate caused by the dimethylbenzene of xiaojin pill group mouse is significantly lower than blank group, little Jin Chinese medicine
Ear swelling rate caused by the dimethylbenzene of compound plastics group mouse is significantly lower than blank group and xiaojin pill group, illustrates xiaojin pill and Ben Fa
Bright little Jin Chinese medicine compound prescription plastics, which close object, can mitigate ear swelling caused by mouse dimethylbenzene, but little Jin Chinese medicine compound prescription film of the present invention
Ear swelling caused by agent mitigation mouse dimethylbenzene is more efficient compared with xiaojin pill, i.e.,：Little Jin Chinese medicine compound prescription plastics of the invention, percutaneously
Be administered it is rapid-action, can be in lesion part fast onset anti-inflammatory effect.
2, analgesia effect confirmatory experiment method
Take ICR mouse, 17~21g of weight or so, half male and half female.It is randomly divided into 3 groups, every group 20.Mouse peritoneal face is equal
Make depilation processing.Blank group smears the plastics for being free of little Jin extract, little Jin plastics group stick size it is certain containing little Jin
Extract gel emplastrum, xiaojin pill group intragastric administration on mice are converted into the xiaojin pill suspension of equal dose.After medication 30min, respectively give
Medicine group dispels externally applied plaster.Each group mouse peritoneal injects 0.5% acetic acid 0.2ml/ only, each group in 15min after observation injection acetic acid
The writhing response number of animals and writhing response number that mouse occurs.
4, analgesia effect confirmatory experiment result
Experimental result is shown in Table 4.
The influence (mean ± S) of 4 little Jin Chinese medicine compound prescription plastics of table and xiaojin pill to acetic acid induced mice pain reaction
The experimental results showed that xiaojin pill group and little Jin plastics group are apparently higher than blank group without writhing response number of animals,
Writhing response number is significantly lower than blank group in 15min, illustrates xiaojin pill and little Jin Chinese medicine compound prescription plastics of the present invention to small
The stimulation of mouse acetic acid causes pain reaction to have inhibiting effect；Little Jin plastics group is higher than xiaojin pill group without writhing response number of animals,
Writhing response number is lower than xiaojin pill group in 15min, illustrates that little Jin Chinese medicine compound prescription plastics of the present invention can faster inhibit mouse second
Acid stimulation leads to pain reaction, i.e.,：Little Jin Chinese medicine compound prescription plastics of the invention, percutaneous dosing is rapid-action, can be in lesion part
Fast onset analgesic activity.
Above-mentioned description of test, little Jin Chinese medicine compound prescription plastics provided by the invention, percutaneous dosing is rapid-action, can be in lesion office
Portion's fast onset anti-inflammatory and analgesic effect.
To sum up, little Jin Chinese medicine compound prescription plastics of the invention can effectively treat shingles zoster, it may also be used for adjuvant treatment first
Shape gland tubercle, the proliferation of mammary gland, and auxiliaring effect is obvious.Little Jin Chinese medicine compound prescription plastics of the invention, percutaneous dosing is rapid-action, can
In lesion part fast onset anti-inflammatory and analgesic effect.
Claims (11)
1. a kind of little Jin Chinese medicine compound prescription plastics, it is characterised in that：It is by little Jin extract, filmogen, plasticizer, transdermal suction
It receives promotor, organic solvent and water to be prepared, the weight proportion of supplementary material is：
It is 20~50 parts of little Jin extract, 10~20 parts of filmogen, 4~12 parts of plasticizer, 0.1~5 part of transdermal penetration agent, organic
30~50 parts of solvent；
Wherein, the little Jin extract is prepared by following weight proportion bulk pharmaceutical chemicals：
20~40 parts of Moschus, 130~170 parts of wild aconite root, 130~170 parts of semen momordicae, 130~170 parts of resina liquidamberis, pheretima 130~
170 parts, 130~170 parts of excrementum pteropi, 65~85 parts of olibanum, 65~85 parts of myrrh, 65~85 parts of Radix Angelicae Sinensis, 8~16 parts of capital ink.
2. little Jin Chinese medicine compound prescription plastics according to claim 1, it is characterised in that：It is auxiliary by the original of following weight proportion
Expect into：
It is 25~45 parts of little Jin extract, 12~20 parts of filmogen, 5~10 parts of plasticizer, 0.1~4 part of transdermal penetration agent, organic
35~45 parts of solvent.
3. little Jin Chinese medicine compound prescription plastics according to claim 2, it is characterised in that：It is auxiliary by the original of following weight proportion
Expect into：
It is 30~40 parts of little Jin extract, 14~18 parts of filmogen, 6~9 parts of plasticizer, 0.2~4 part of transdermal penetration agent, organic
37~43 parts of solvent.
4. little Jin Chinese medicine compound prescription plastics according to claim 1, it is characterised in that：It is auxiliary by the original of following weight proportion
Expect into：
35 parts of little Jin extract, 15 parts of filmogen, 7 parts of plasticizer, 1 part of transdermal penetration agent, 42 parts of organic solvent system；
Wherein, the little Jin extract is prepared by following weight proportion bulk pharmaceutical chemicals：
30 parts of Moschus, 150 parts of wild aconite root, 150 parts of semen momordicae, 150 parts of resina liquidamberis, 150 parts of pheretima, 150 parts of excrementum pteropi, olibanum 75
12 parts of part, 75 parts of myrrh, 75 parts of Radix Angelicae Sinensis and capital ink.
5. little Jin Chinese medicine compound prescription plastics according to any one of claims 1-4, it is characterised in that：The extract
It is ethanol extract.
6. little Jin Chinese medicine compound prescription plastics according to claim 5, it is characterised in that：The extract be by medicinal material by
Aforementioned weight proportion uses 40% ethanol water to be extracted as solvent, solid-liquid ratio 1:12, extraction time 3h, medicinal extract
Relative density is 1.1.
7. little Jin Chinese medicine compound prescription plastics described in -6 any one according to claim 1, it is characterised in that：The filmogen
Composition including one or more of bletilla glue, chitosan, polyvinyl alcohol；Preferably, the filmogen is polyethylene
Alcohol；；The polyvinyl alcohol is selected from one or more of polyvinyl alcohol 05-88, polyvinyl alcohol 17-88, polyvinyl alcohol 124；
The plasticizer includes one or more of glycerol, propylene glycol, polyethylene glycol composition；Preferably, the plasticizer
For glycerol；
The transdermal penetration agent includes：One or more of azone, borneol, oleic acid composition；Preferably, the skin bleeding agent
For the composition of azone and borneol；
The organic solvent includes one or more of acetone, ethyl alcohol, phenol composition；Preferably, the organic solvent is
Ethyl alcohol.
8. little Jin Chinese medicine compound prescription plastics according to claim 7, it is characterised in that：The polyvinyl alcohol is polyvinyl alcohol
124；The portfolio ratio of azone and borneol is 2 in the transdermal penetration agent：3~2:1；Preferably, the composition azone and
The portfolio ratio of borneol is 1:1.
9. the preparation method of xiaojin pill Chinese medicine compound prescription plastics described in claim 7 or 8 any one, it is characterised in that：It
Include the following steps：
(1) polyvinyl alcohol and sodium carboxymethylcellulose are dipped to expansion with suitable purified water respectively, are placed in water-bath and heat
To being completely dissolved, matrix is used as after then mixing the two；
(2) little Jin extract is dissolved with ethanol solution, is added in the matrix under constant stirring, and added in water-bath
Heat, stirring are then cooled to room temperature to no alcohol taste；
(3) borneol, azone are mixed with glycerol and grind even, entered in the solution that step (2) obtains, ethyl alcohol is added, stir evenly to get
The little Jin Chinese medicine compound prescription plastics.
10. purposes of the plastics described in claim 1-8 any one in preparation treatment shingles medications.
11. plastics described in claim 1-8 any one are in preparation adjuvant treatment thyroid gland nodule, proliferation of mammary gland drug
Purposes.
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Application publication date: 20181123 |