CN108852966A - It is a kind of to adjust hormonal equilibrium cream and preparation method thereof - Google Patents

It is a kind of to adjust hormonal equilibrium cream and preparation method thereof Download PDF

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CN108852966A
CN108852966A CN201810879802.2A CN201810879802A CN108852966A CN 108852966 A CN108852966 A CN 108852966A CN 201810879802 A CN201810879802 A CN 201810879802A CN 108852966 A CN108852966 A CN 108852966A
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parts
phase component
phase
extract
hormonal equilibrium
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陈思思
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Guangzhou Witton Biotechnology Co Ltd
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Guangzhou Witton Biotechnology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41Amines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73Polysaccharides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9728Fungi, e.g. yeasts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9794Liliopsida [monocotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/85Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine

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Abstract

Hormonal equilibrium cream is adjusted the present invention relates to a kind of, is grouped as by each group of following parts by weight:A phase component:Sucrose Polystearic Acid Esters, cetostearyl alcohol, stearine, saualane, hydrogenated jojoba oil, dimethyl silicone polymer, caprylic/capric triglyceride, phytosphingosine;B phase component:Water, glycine betaine, glycerol polymethacrylates, Gantrez AN-119 butyl ester;C phase component:Isoflavones, saccharomycete/potato extract tunning filtrate, length are away from Shorthorned Epimedium P.E, blackberry lily root extract, palmityl grape seed extract, yeast extract, musk rose oil, hexapeptide -3, beta glucan;D phase component:Methylisothiazolinone, essence;Also disclose preparation method.The invention belongs to phytohormones, these special plant component energy exciting humans voluntarily generate required hormone, and maintain equilibrium state, so the ill-effect of hormone excess and synthetic hormones will not be generated.

Description

It is a kind of to adjust hormonal equilibrium cream and preparation method thereof
Technical field
The present invention relates to technical field of skin care, especially a kind of to adjust hormonal equilibrium cream and preparation method thereof.
Background technique
The influence of internal hormone how many pairs of human body psychological conditions of content is very important, has notably, it is even more returned it In the measurement agent in woman's youth.With the continuous improvement of people's living standards, demand of the people to cosmetics is continuously improved.At present Hormone cream on the market is being improved primarily directed to hormone, based on natural hormone forerunner's therapy, as common Chinese yam frost contains the supplemental chemicals such as sodium hyaluronate more and is not easy to absorb.Estrogen for oral administration that general ob-gyn is opened and Though lutern has certain effect, result of study shows the risk that will increase breast cancer, heart disease, apoplexy.
Summary of the invention
The purpose of the present invention is to overcome the shortcomings of the existing technology, provides and a kind of adjusts hormonal equilibrium cream and its preparation Method.
The purpose of the present invention is achieved through the following technical solutions:It is a kind of to adjust hormonal equilibrium cream, by following weight The each group of part is grouped as:
A phase component:5~12 parts of Sucrose Polystearic Acid Esters, 3~5 parts of cetostearyl alcohols, 4~7 parts of stearines, 6~ 15 parts of saualanes, 2~5 parts of hydrogenated jojoba oils, 4~8 parts of dimethyl silicone polymers, 5~7 parts of caprylic/capric triglycerides, 1 ~6 parts of phytosphingosines;
B phase component:20~30 parts of water, 1~3 part of glycine betaine, 3~5 parts of glycerol polymethacrylates, 2~6 parts of PVM/MA Copolymer butyl ester;
C phase component:1~4 part of isoflavones, 10~15 parts of saccharomycete/potato extract tunning filtrate, 3~9 Part is long to extract away from Shorthorned Epimedium P.E, 2~5 parts of blackberry lily root extracts, 3~4 parts of palmityl grape seed extracts, 1~2 part of yeast Object, 1~2 part of musk rose oil, 0.1~0.5 part of hexapeptide -3,1~4 part of beta glucan;
D phase component:0.01~0.06 part of methylisothiazolinone, 0.1~0.5 part of essence.
Further, the A phase component further includes A1 phase component:0.01~0.04 part of tocopherol acetate, 0.02~ 0.04 part of Nipasol.
Further, the B phase component further includes B1 phase component:0.01~0.03 part of methyl hydroxybenzoate.
Further, the B phase component further includes B2 phase component:3~12 parts of Sodium Hyaluronates, 5~11 parts of glycerol.
Further, the length is to grow away from Herba Epimedii flower extract, length away from Folium Epimedii extract away from Shorthorned Epimedium P.E Or it is long away from one of Herba Epimedii stem extraction or a variety of mixtures.
A kind of preparation method adjusting hormonal equilibrium cream, includes the following steps:
S1, after A phase component to be warming up to 85~90 DEG C, heat preservation 15~25 minutes, 80 DEG C are cooled to;
S2, B phase component is warming up to 90~100 DEG C, wherein the dispersion of colloid class completely, after heat preservation 20~25 minutes, cools down To 80 DEG C;
S3, B phase component mixed phase is pumped into preheated emulsion pot, then is slowly pumped into A phase component mixed phase, pre-emulsification 10 It~15 minutes, homogeneous 5~10 minutes, stirs evenly, vacuumizes defoaming cooling;
S4, C phase component is added when being cooled to 50 DEG C, and keeps the temperature, temperature fluctuations range is stirred between 2~3 DEG C It mixes uniformly, then proceedes to cool down;
S5, when being cooled to 40 DEG C of addition D phase components, and keep the temperature, temperature fluctuations range is between 2~3 DEG C, stirring Uniformly, it then proceedes to cool down;
S6,30 DEG C, after sampling analysis result is qualified are reduced to temperature, discharging;
S7, the material to take the dish out of the pot are pushed into rest chamber, filling after ageing 12 hours, packaging.
Further, in step S1, when A phase component heats up, temperature rise rate is 2~4 DEG C/min;In step S2, B phase group When part heating, temperature rise rate is 3~5 DEG C/min.
Further, in step S3, homogenizing step is specially:First 3 minutes of homogeneous, homogeneous speed be 1200~ Then 1500rpm improves homogeneous speed to 1800~2000rpm.
Further, in step S3, mixing speed is 30~60rpm, and uses positive and negative rotation alternate agitation.
Further, in step S3, for the vacuum degree vacuumized between -0.06Mpa~-0.09Mpa, defoaming 8~12 is small When.
The present invention has the following advantages that:
1, the invention belongs to phytohormone, these special plant component energy exciting humans voluntarily generate required lotus You cover, and maintain equilibrium state, so the ill-effect of hormone excess and synthetic hormones will not be generated.
2, improve skin metabolism, promote nutrient absorption, make the delicate smooth high resilience of skin, comprehensive adjusting women Reproductive system function alleviates menopause symptom, and pleasure mood adjusts both sexes happiness state, promotes charisma, increases self-confident Sense, makes feminine flavour full, can chill out, resistance to compression, sleeping, supplements hormone in simultaneously balanced body, maintains internal hormone quality, It enables each function of body maintain normal operation, promotes the skin degree of packing.
Specific embodiment
Below with reference to embodiment, the present invention will be further described, but protection scope of the present invention is not limited to following institute It states.
【Embodiment 1】:
It is a kind of to adjust hormonal equilibrium cream, it is grouped as by each group of following parts by weight:
A phase component:12 parts of Sucrose Polystearic Acid Esters, 3 parts of cetostearyl alcohols, 7 parts of stearines, 6 parts of saualanes, 2 Part hydrogenated jojoba oil, 4 parts of dimethyl silicone polymers, 7 parts of caprylic/capric triglycerides, 1 part of phytosphingosine;
A1 phase component:0.04 part of tocopherol acetate, 0.02 part of Nipasol;
B phase component:20 parts of water, 1 part of glycine betaine, 5 parts of glycerol polymethacrylates, 6 parts of Gantrez AN-119 butyl esters;
B1 phase component:0.03 part of methyl hydroxybenzoate;
B2 phase component:12 parts of Sodium Hyaluronates, 5 parts of glycerol;
C phase component:It is 1 part of isoflavones, 15 parts of saccharomycete/potato extract tunning filtrate, 3 parts long away from excessive sheep Leaves of pulse plants extract, 5 parts of blackberry lily root extracts, 3 parts of palmityl grape seed extracts, 2 parts of yeast extracts, 2 parts of musk rose oils, 0.5 part of hexapeptide -3,1 part of beta glucan;
D phase component:0.06 part of methylisothiazolinone, 0.5 part of essence.
Further, the length is to grow away from Herba Epimedii flower extract, length away from Folium Epimedii extract away from Shorthorned Epimedium P.E Or it is long away from one of Herba Epimedii stem extraction or a variety of mixtures.
A kind of preparation method adjusting hormonal equilibrium cream, includes the following steps:
S1, after A phase component to be warming up to 85 DEG C, heat preservation 25 minutes, 80 DEG C, when A phase component heats up are cooled to, temperature rise rate It is 4 DEG C/min;
S2, B phase component is warming up to 90 DEG C, wherein the dispersion of colloid class completely, after heat preservation 25 minutes, is cooled to 80 DEG C, B phase When component heats up, temperature rise rate is 3 DEG C/min;
S3, B phase component mixed phase is pumped into preheated emulsion pot, then is slowly pumped into A phase component mixed phase, pre-emulsification 10 Minute, homogeneous 5 minutes, homogenizing step was specially:First 3 minutes of homogeneous, homogeneous speed are 1500rpm, then improve homogeneous speed Degree stirs evenly, mixing speed 30rpm to 2000rpm, and uses positive and negative rotation alternate agitation, vacuumizes defoaming cooling, takes out true Empty vacuum degree is -0.09Mpa, is defoamed 8 hours;
S4, C phase component is added when being cooled to 50 DEG C, and keeps the temperature, temperature fluctuations range is stirred between 2~3 DEG C It mixes uniformly, then proceedes to cool down;
S5, when being cooled to 40 DEG C of addition D phase components, and keep the temperature, temperature fluctuations range is between 2~3 DEG C, stirring Uniformly, it then proceedes to cool down;
S6,30 DEG C, after sampling analysis result is qualified are reduced to temperature, discharging;
S7, the material to take the dish out of the pot are pushed into rest chamber, filling after ageing 12 hours, packaging.
【Embodiment 2】:
It is a kind of to adjust hormonal equilibrium cream, it is grouped as by each group of following parts by weight:
A phase component:5 parts of Sucrose Polystearic Acid Esters, 5 parts of cetostearyl alcohols, 4 parts of stearines, 15 parts of saualanes, 5 Part hydrogenated jojoba oil, 8 parts of dimethyl silicone polymers, 5 parts of caprylic/capric triglycerides, 6 parts of phytosphingosines;
A1 phase component:0.01 part of tocopherol acetate, 0.04 part of Nipasol;
B phase component:30 parts of water, 3 parts of glycine betaines, 3 parts of glycerol polymethacrylates, 2 parts of Gantrez AN-119 butyl esters;
B1 phase component:0.01 part of methyl hydroxybenzoate;
B2 phase component:3 parts of Sodium Hyaluronates, 11 parts of glycerol;
C phase component:It is 4 parts of isoflavones, 10 parts of saccharomycete/potato extract tunning filtrate, 9 parts long away from excessive sheep Leaves of pulse plants extract, 2 parts of blackberry lily root extracts, 4 parts of palmityl grape seed extracts, 1 part of yeast extract, 1 part of musk rose oil, 0.1 part of hexapeptide -3,4 parts of beta glucans;
D phase component:0.01 part of methylisothiazolinone, 0.1 part of essence.
Further, the length is to grow away from Herba Epimedii flower extract, length away from Folium Epimedii extract away from Shorthorned Epimedium P.E Or it is long away from one of Herba Epimedii stem extraction or a variety of mixtures.
A kind of preparation method adjusting hormonal equilibrium cream, includes the following steps:
S1, after A phase component to be warming up to 90 DEG C, heat preservation 15 minutes, 80 DEG C, when A phase component heats up are cooled to, temperature rise rate It is 2 DEG C/min;
S2, B phase component is warming up to 100 DEG C, wherein completely, heat preservation after twenty minutes, is cooled to 80 DEG C, B to the dispersion of colloid class When phase component heats up, temperature rise rate is 5 DEG C/min;
S3, B phase component mixed phase is pumped into preheated emulsion pot, then is slowly pumped into A phase component mixed phase, pre-emulsification 15 Minute, homogeneous 10 minutes, homogenizing step was specially:First 3 minutes of homogeneous, homogeneous speed are 1200rpm, then improve homogeneous speed Degree stirs evenly, mixing speed 60rpm to 1800rpm, and uses positive and negative rotation alternate agitation, vacuumizes defoaming cooling, takes out true Empty vacuum degree is -0.06Mpa, is defoamed 12 hours;
S4, C phase component is added when being cooled to 50 DEG C, and keeps the temperature, temperature fluctuations range is stirred between 2~3 DEG C It mixes uniformly, then proceedes to cool down;
S5, when being cooled to 40 DEG C of addition D phase components, and keep the temperature, temperature fluctuations range is between 2~3 DEG C, stirring Uniformly, it then proceedes to cool down;
S6,30 DEG C, after sampling analysis result is qualified are reduced to temperature, discharging;
S7, the material to take the dish out of the pot are pushed into rest chamber, filling after ageing 12 hours, packaging.
【Embodiment 3】:
It is a kind of to adjust hormonal equilibrium cream, it is grouped as by each group of following parts by weight:
A phase component:8 parts of Sucrose Polystearic Acid Esters, 4 parts of cetostearyl alcohols, 5 parts of stearines, 10 parts of saualanes, 4 Part hydrogenated jojoba oil, 6 parts of dimethyl silicone polymers, 6 parts of caprylic/capric triglycerides, 3 parts of phytosphingosines;
A1 phase component:0.03 part of tocopherol acetate, 0.03 part of Nipasol;
B phase component:25 parts of water, 2 parts of glycine betaines, 4 parts of glycerol polymethacrylates, 4 parts of Gantrez AN-119 butyl esters;
B1 phase component:0.02 part of methyl hydroxybenzoate;
B2 phase component:7 parts of Sodium Hyaluronates, 8 parts of glycerol;
C phase component:It is 3 parts of isoflavones, 12 parts of saccharomycete/potato extract tunning filtrate, 6 parts long away from excessive sheep Leaves of pulse plants extract, 4 parts of blackberry lily root extracts, 3.5 parts of palmityl grape seed extracts, 1.5 parts of yeast extracts, 1.5 parts of Moschus roses Rare oil, 0.4 part of hexapeptide -3,3 parts of beta glucans;
D phase component:0.04 part of methylisothiazolinone, 0.3 part of essence.
Further, the length is to grow away from Herba Epimedii flower extract, length away from Folium Epimedii extract away from Shorthorned Epimedium P.E Or it is long away from one of Herba Epimedii stem extraction or a variety of mixtures.
A kind of preparation method adjusting hormonal equilibrium cream, includes the following steps:
S1, A phase component is warming up to 88 DEG C, heat preservation after twenty minutes, is cooled to 80 DEG C, when A phase component heats up, temperature rise rate It is 3 DEG C/min;
S2, B phase component is warming up to 95 DEG C, wherein the dispersion of colloid class completely, after heat preservation 22 minutes, is cooled to 80 DEG C, B phase When component heats up, temperature rise rate is 4 DEG C/min;
S3, B phase component mixed phase is pumped into preheated emulsion pot, then is slowly pumped into A phase component mixed phase, pre-emulsification 13 Minute, homogeneous 8 minutes, homogenizing step was specially:First 3 minutes of homogeneous, homogeneous speed are 1300rpm, then improve homogeneous speed Degree stirs evenly, mixing speed 45rpm to 1900rpm, and uses positive and negative rotation alternate agitation, vacuumizes defoaming cooling, takes out true Empty vacuum degree is -0.08Mpa, is defoamed 10 hours;
S4, C phase component is added when being cooled to 50 DEG C, and keeps the temperature, temperature fluctuations range is stirred between 2~3 DEG C It mixes uniformly, then proceedes to cool down;
S5, when being cooled to 40 DEG C of addition D phase components, and keep the temperature, temperature fluctuations range is between 2~3 DEG C, stirring Uniformly, it then proceedes to cool down;
S6,30 DEG C, after sampling analysis result is qualified are reduced to temperature, discharging;
S7, the material to take the dish out of the pot are pushed into rest chamber, filling after ageing 12 hours, packaging.
【Embodiment 4】:
It is a kind of to adjust hormonal equilibrium cream, it is grouped as by each group of following parts by weight:
A phase component:7 parts of Sucrose Polystearic Acid Esters, 3 parts of cetostearyl alcohols, 7 parts of stearines, 12 parts of saualanes, 3 Part hydrogenated jojoba oil, 5 parts of dimethyl silicone polymers, 6 parts of caprylic/capric triglycerides, 4 parts of phytosphingosines;
A1 phase component:0.02 part of tocopherol acetate, 0.02 part of Nipasol;
B phase component:22 parts of water, 3 parts of glycine betaines, 4 parts of glycerol polymethacrylates, 3 parts of Gantrez AN-119 butyl esters;
B1 phase component:0.01 part of methyl hydroxybenzoate;
B2 phase component:6 parts of Sodium Hyaluronates, 7 parts of glycerol;
C phase component:It is 2 parts of isoflavones, 13 parts of saccharomycete/potato extract tunning filtrate, 7 parts long away from excessive sheep Leaves of pulse plants extract, 3 parts of blackberry lily root extracts, 3 parts of palmityl grape seed extracts, 2 parts of yeast extracts, 2 parts of musk rose oils, 0.3 part of hexapeptide -3,2 parts of beta glucans;
D phase component:0.03 part of methylisothiazolinone, 0.2 part of essence.
Further, the length is to grow away from Herba Epimedii flower extract, length away from Folium Epimedii extract away from Shorthorned Epimedium P.E Or it is long away from one of Herba Epimedii stem extraction or a variety of mixtures.
A kind of preparation method adjusting hormonal equilibrium cream, includes the following steps:
S1, after A phase component to be warming up to 86 DEG C, heat preservation 22 minutes, 80 DEG C, when A phase component heats up are cooled to, temperature rise rate It is 2 DEG C/min;
S2, B phase component is warming up to 100 DEG C, wherein the dispersion of colloid class completely, after heat preservation 25 minutes, is cooled to 80 DEG C, B When phase component heats up, temperature rise rate is 3 DEG C/min;
S3, B phase component mixed phase is pumped into preheated emulsion pot, then is slowly pumped into A phase component mixed phase, pre-emulsification 12 Minute, homogeneous 6 minutes, homogenizing step was specially:First 3 minutes of homogeneous, homogeneous speed are 1300rpm, then improve homogeneous speed Degree stirs evenly, mixing speed 45rpm to 2000rpm, and uses positive and negative rotation alternate agitation, vacuumizes defoaming cooling, takes out true Empty vacuum degree defoams 12 hours between -0.09Mpa;
S4, C phase component is added when being cooled to 50 DEG C, and keeps the temperature, temperature fluctuations range is stirred between 2~3 DEG C It mixes uniformly, then proceedes to cool down;
S5, when being cooled to 40 DEG C of addition D phase components, and keep the temperature, temperature fluctuations range is between 2~3 DEG C, stirring Uniformly, it then proceedes to cool down;
S6,30 DEG C, after sampling analysis result is qualified are reduced to temperature, discharging;
S7, the material to take the dish out of the pot are pushed into rest chamber, filling after ageing 12 hours, packaging.
It although an embodiment of the present invention has been shown and described, for the ordinary skill in the art, can be with A variety of variations, modification, replacement can be carried out to these embodiments without departing from the principles and spirit of the present invention by understanding And modification, the scope of the present invention is defined by the appended.

Claims (10)

1. a kind of adjust hormonal equilibrium cream, it is characterised in that:It is grouped as by each group of following parts by weight:
A phase component:5~12 parts of Sucrose Polystearic Acid Esters, 3~5 parts of cetostearyl alcohols, 4~7 parts of stearines, 6~15 parts Saualane, 2~5 parts of hydrogenated jojoba oils, 4~8 parts of dimethyl silicone polymers, 5~7 parts of caprylic/capric triglycerides, 1~6 part Phytosphingosine;
B phase component:20~30 parts of water, 1~3 part of glycine betaine, 3~5 parts of glycerol polymethacrylates, 2~6 parts of PVM/MA copolymerization Object butyl ester;
C phase component:It is 1~4 part of isoflavones, 10~15 parts of saccharomycete/potato extract tunning filtrate, 3~9 parts long Away from Shorthorned Epimedium P.E, 2~5 parts of blackberry lily root extracts, 3~4 parts of palmityl grape seed extracts, 1~2 part of yeast extract, 1 ~2 parts of musk rose oils, 0.1~0.5 part of hexapeptide -3,1~4 part of beta glucan;
D phase component:0.01~0.06 part of methylisothiazolinone, 0.1~0.5 part of essence.
2. a kind of according to claim 1 adjust hormonal equilibrium cream, it is characterised in that:The A phase component further includes A1 Phase component:0.01~0.04 part of tocopherol acetate, 0.02~0.04 part of Nipasol.
3. a kind of according to claim 1 adjust hormonal equilibrium cream, it is characterised in that:The B phase component further includes B1 Phase component:0.01~0.03 part of methyl hydroxybenzoate.
4. a kind of according to claim 3 adjust hormonal equilibrium cream, it is characterised in that:The B phase component further includes B2 Phase component:3~12 parts of Sodium Hyaluronates, 5~11 parts of glycerol.
5. a kind of according to claim 1 adjust hormonal equilibrium cream, it is characterised in that:The length is away from Shorthorned Epimedium P.E For it is long away from Herba Epimedii flower extract, it is long away from Folium Epimedii extract or long away from one of Herba Epimedii stem extraction or a variety of mixed Close object.
6. a kind of preparation method for adjusting hormonal equilibrium cream as described in Claims 1 to 5 any one, it is characterised in that: Include the following steps:
S1, after A phase component to be warming up to 85~90 DEG C, heat preservation 15~25 minutes, 80 DEG C are cooled to;
S2, B phase component is warming up to 90~100 DEG C, wherein the dispersion of colloid class completely, after heat preservation 20~25 minutes, is cooled to 80 ℃;
S3, B phase component mixed phase is pumped into preheated emulsion pot, then is slowly pumped into A phase component mixed phase, pre-emulsification 10~15 Minute, it homogeneous 5~10 minutes, stirs evenly, vacuumizes defoaming cooling;
S4, C phase component is added when being cooled to 50 DEG C, and keeps the temperature, for temperature fluctuations range between 2~3 DEG C, stirring is equal It is even, it then proceedes to cool down;
S5, when being cooled to 40 DEG C of addition D phase components, and keep the temperature, for temperature fluctuations range between 2~3 DEG C, stirring is equal It is even, it then proceedes to cool down;
S6,30 DEG C, after sampling analysis result is qualified are reduced to temperature, discharging;
S7, the material to take the dish out of the pot are pushed into rest chamber, filling after ageing 12 hours, packaging.
7. a kind of according to claim 6 adjust hormonal equilibrium cream, it is characterised in that:In step S1, the heating of A phase component When, temperature rise rate is 2~4 DEG C/min;In step S2, when B phase component heats up, temperature rise rate is 3~5 DEG C/min.
8. a kind of according to claim 6 adjust hormonal equilibrium cream, it is characterised in that:In step S3, homogenizing step tool Body is:First 3 minutes of homogeneous, homogeneous speed are 1200~1500rpm, then improve homogeneous speed to 1800~2000rpm.
9. a kind of according to claim 6 adjust hormonal equilibrium cream, it is characterised in that:In step S3, mixing speed is 30~60rpm, and use positive and negative rotation alternate agitation.
10. a kind of according to claim 6 adjust hormonal equilibrium cream, it is characterised in that:In step S3, what is vacuumized is true Reciprocal of duty cycle defoams 8~12 hours between -0.06Mpa~-0.09Mpa.
CN201810879802.2A 2018-08-03 2018-08-03 It is a kind of to adjust hormonal equilibrium cream and preparation method thereof Pending CN108852966A (en)

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CN113499287A (en) * 2021-07-01 2021-10-15 浙江辰海生命科学有限公司 Potato fermentation product, skin external preparation containing potato fermentation product, and preparation method and application of potato fermentation product
CN114767582A (en) * 2022-04-25 2022-07-22 广州腾麟生物科技有限公司 Cream for promoting balanced secretion of hormones and preparation method thereof
CN116327632A (en) * 2023-04-14 2023-06-27 广州维顿生物科技有限公司 Cream for promoting hormone balance secretion and preparation method thereof

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Cited By (4)

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Publication number Priority date Publication date Assignee Title
CN113499287A (en) * 2021-07-01 2021-10-15 浙江辰海生命科学有限公司 Potato fermentation product, skin external preparation containing potato fermentation product, and preparation method and application of potato fermentation product
CN113499287B (en) * 2021-07-01 2023-01-17 浙江辰海生命科学有限公司 Potato ferment, skin external agent containing potato ferment, and preparation method and application of potato ferment
CN114767582A (en) * 2022-04-25 2022-07-22 广州腾麟生物科技有限公司 Cream for promoting balanced secretion of hormones and preparation method thereof
CN116327632A (en) * 2023-04-14 2023-06-27 广州维顿生物科技有限公司 Cream for promoting hormone balance secretion and preparation method thereof

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Application publication date: 20181123