CN108852890A - A kind of mild makeup removing breast and preparation method thereof - Google Patents
A kind of mild makeup removing breast and preparation method thereof Download PDFInfo
- Publication number
- CN108852890A CN108852890A CN201811014811.1A CN201811014811A CN108852890A CN 108852890 A CN108852890 A CN 108852890A CN 201811014811 A CN201811014811 A CN 201811014811A CN 108852890 A CN108852890 A CN 108852890A
- Authority
- CN
- China
- Prior art keywords
- makeup removing
- added
- parts
- mass ratio
- take
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/63—Steroids; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9771—Ginkgophyta, e.g. Ginkgoaceae [Ginkgo family]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
- A61Q1/14—Preparations for removing make-up
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Emergency Medicine (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a kind of mild makeup removing breasts and preparation method thereof, belong to cosmetic technical field.The present invention is using linseed oil, camellia oil as raw material, form the stabilization makeup removing breast base structure of Water-In-Oil, has the function of anti-acne, anti-inflammatory, sun-proof, while oil emulsion has property soluble easily in water, so that only needing to be rinsed with clear water can be clean by Fouling Cleaning on the face；By the way that conjugated linoleic acid ethyl ester is added as microsphere, the immobilization to Aspergillus oryzae lipase is carried out, conjugated linoleic acid ethyl ester is added and is reacted with the catalysis of lecithin, promote catalytic conversion efficiency, phospholipid moisturizing repairing activity agent is formed, stimulation sexual behaviour of the makeup removing breast to skin surface is reduced；The protection of skin surface cutin when introducing ursolic acid and glycyrrhizic acid to makeup removing reaches minimum to the stimulation of skin, can also form antimicrobial protection to makeup removing breast, prevent the rotten damage to skin.The present invention solves that current makeup removing breast is larger to skin irritation, the low problem of makeup removal efficiency.
Description
Technical field
The invention belongs to cosmetic fields, and in particular to a kind of mild makeup removing breast and preparation method thereof.
Background technique
With the improvement of living standards, more and more people can be accustomed to making up, but after face makeup, if do not removed thorough
Bottom, remaining cosmetics can cause the pore of skin of face to block, and lead to skin oil and fat water oil dyssecretosis, so as to cause Cuo
Sore, acne and blackhead etc. make us the skin problem of puzzlement.Meanwhile the residual of cosmetics to skin there is a great harm for, if cannot
It cleans out in time, can be with the breathing of pore, into hair follicle, the problem of forming tumour, in long-term existence and skin surface
Just it is difficult to clear up away again, so, the makeup removing link of skin is particularly significant.At this moment the selection of makeup removal products is just particularly important
?.The makeup removal products sold on the market at present are multifarious, and therefore, consumer will follow when selecting makeup removal products
Standard it is main there are two：One, makeup removing is clean；Two, small to the injury of skin.The big multipair skin thorn of makeup removing adornment cream currently on the market
Sharp property is larger, and makeup removal efficiency is low, needs to unload a lot of all over waste makeup removing raw materials, it is therefore desirable to it is high to research and develop a mild makeup removing rate
Makeup removing breast.
Summary of the invention
The technical problems to be solved by the invention：Larger to skin irritation for current makeup removing breast, makeup removal efficiency is low
Problem provides a kind of mild makeup removing breast and preparation method thereof.
In order to solve the above technical problems, the present invention is using technical solution as described below：
A kind of mild makeup removing breast, including the agent of cutin protection activity, smooth skin activating agent, anticorrosive additive, which is characterized in that
It further include makeup removing oil-based material, moisturizing repairing activity agent；
The preparation method of the makeup removing breast base-material, includes the following steps：
According to the mass fraction, 3 ~ 5 parts of lauryl sodium sulfate, 2 ~ 6 parts of Tween-20s, 5 ~ 8 parts of whey protein isolates are taken, are warming up to
60 ~ 70 DEG C are stirred, and obtain mixture, take mixture in mass ratio 15 ~ 18：30~40：40 ~ 50 are added linseed oil, camellia oil
It is stirred, obtains makeup removing breast base-material.
It is described linseed oil is added, camellia oil is stirred condition：1 ~ 3h is stirred in 70 ~ 90 DEG C.
The moisturizing repairing activity agent：
（1）Take Aspergillus oryzae lipase in mass ratio 2 ~ 4：10 ~ 15 are added phosphate buffer, 20 ~ 30min of ultrasound, and centrifugation takes
Clear liquid, according to the mass fraction, take 80 ~ 90 portions of supernatants, 0.3 ~ 0.5 part of conjugated linoleic acid ethyl ester, 0.3 ~ 0.6 part of Tween-80,7 ~
10 parts of dehydrated alcohols obtain oscillation liquid in 150r/min, 20 ~ 25 DEG C of 15 ~ 20min of oscillation, take oscillation liquid in mass ratio 100 ~ 120：
3 ~ 5 are added macroreticular resin, are warming up to 30 ~ 35 DEG C of heat preservations, filter, and take and filter slag rotary evaporation, and freeze-drying must be freeze-dried
Object；
（2）According to the mass fraction, 1 ~ 3 part of freeze-drying object, 20 ~ 30 parts of n-hexanes, 5 ~ 9 parts of conjugated linoleic acid ethyl esters, 7 ~ 9 parts are taken
Lecithin is stirred in 50 ~ 55 DEG C, is stood, then instill the conjugated linoleic acid ethyl ester of lecithin quality 40 ~ 50%, and heat preservation 18 ~
20h, enzyme deactivation, centrifugation take supernatant rotary evaporation, obtain rotary evaporation object, rotary evaporation object in mass ratio 1 ~ 3：8 ~ 10 are added third
Ketone, centrifugation take precipitating vacuum distillation to get moisturizing repairing activity agent.
The cutin protection activity agent：Take ursolic acid in mass ratio 2 ~ 5：1 ~ 3 be added glycyrrhizic acid mixing to get.
The smooth skin activating agent：Take carboxymethyl yeast dextran in mass ratio 1 ~ 3：2~5：1 ~ 3 is added ascorbic acid
Methyl-monosilane alcohol pectate, Maca extract mixing to get.
The anticorrosive additive：Take lactobacillus peptide in mass ratio 3 ~ 6：1 ~ 3 be added ginkgo biloba p.e mixing to get.
The preparation method includes the following steps：
Unloading adornment oil-based material in mass ratio 10 ~ 20：1 ~ 3 is added polyglycerol polyricinoleate, and it is mixed to be warming up to 70 ~ 80 DEG C of stirrings
Close, obtain mixed liquor a, according to the mass fraction, take 2 ~ 5 parts of moisturizing repairing activity agent, 1 ~ 4 part of cutin protection activity agent, 1 ~ 3 part it is smooth
Skin activating agent, 0.3 ~ 0.6 part of anticorrosive additive, 30 ~ 50 parts of glycerine, are stirred in 35 ~ 40 DEG C, obtain mixed liquor b, take mixed
Close liquid b in mass ratio 8 ~ 10：5 ~ 7 addition mixed liquor a are stirred, and homogeneous is to get mild makeup removing breast.
The present invention is compared with other methods, and advantageous effects are：
（1）The present invention using linseed oil, camellia oil as raw material, be added anionic and it is non-from
Sub- surface active agent tween -20 forms the stabilization makeup removing breast base structure of Water-In-Oil, and lauryl sodium sulfate is in lotion water phase
Negatively charged micella is formed, the cation of grease prooxidant is attracted to lotion surface, to reduce water drops surface prooxidant
Concentration, lead to the reduction of lipid oxidation rates, lactalbumin is anti-to have oxidation activity, from having Scavenging ability
Sulfydryl and non-mercaptoamino acid and the limited transition metal chelant ability of lactalbumin, lactalbumin assist dodecyl
Sodium sulphate, Tween-20 form negative electrical charge micella, reduce surface tension, have preferable scalability, so that makeup removing breast base-material is fast
Speed is penetrated into the fold of skin surface, and unsaturated fatty acid, vitamin and carrotene are rich in linseed oil, camellia oil, is had
Anti-acne, anti-inflammatory, sun-proof effect, while oil emulsion have property soluble easily in water, so that only needing to be rinsed with clear water can incite somebody to action
Fouling Cleaning on the face is clean；
（2）The present invention, as microsphere, carries out the immobilization to Aspergillus oryzae lipase by addition conjugated linoleic acid ethyl ester, then
Conjugated linoleic acid ethyl ester is added to react with the catalysis of lecithin, promotes catalytic conversion efficiency, it is living to form phospholipid moisturizing reparation
Property agent, while introducing the characteristic of phosphatide and conjugated linoleic acid ethyl ester, phospholipid molecule has amphiphilic, and water-wet side facilitates skin
Moisturizing, hydrophobic end enables makeup removing breast quickly to dissolve color make-up grease, while helping to construct the biomembrane of skin surface, and gives birth to
Object film has selectivity, and the substance of intraor extracellular can be made to swap, can also cell be prevented to be damaged, conjugated linoleic acid second
Ester facilitates the enhancing of skin surface immunity, carries out radicals scavenging to makeup removing surface skin, reduces makeup removing breast to skin table
The stimulation sexual behaviour in face；
（3）The protection of skin surface cutin, living by enhancing CAT and GPX when present invention introduces ursolic acid and glycyrrhizic acid to makeup removing
Property, the damage of the Hippocampal Neuron Cells of the generation protection kainite induction of oxygen radical is prevented, prevents free radical from generating, from
And the protection to human epidermic keratinocyte's oxidative damage, while carboxymethyl yeast dextran, ascorbic acid methyl silicon is added
The smooth skin activating agent of alkanol pectate, Maca extract as skin, wherein Maca extract contain bioactivity at
Divide macamides and Maca dilute, there is the texture and crease-resistant effect for improving skin, smooth skin surface texture reduces skin table
The recess of the fold in face enables makeup removing breast preferably to spread in skin surface and removes ornaments and formal dress, and makeup removal efficiency is improved, and is added
Lactobacillus peptide, ginkgo biloba p.e carry out natural anti-corrosion, mainly contained in ginkgo biloba extract Total Ginkgo Flavone-Glycoides, ginkgolides,
The substances such as terpene, have the effect of antibacterial, reach minimum to the stimulation of skin, can also form antimicrobial protection to makeup removing breast, prevent
The rotten damage to skin.
Specific embodiment
Aspergillus oryzae lipase：Enzyme activity is 100000 U/g；Macroreticular resin：D4020 adsorbs resin, and monomer is divinylbenzene.
Makeup removing breast base-material：According to the mass fraction, 3 ~ 5 parts of lauryl sodium sulfate, 2 ~ 6 parts of Tween-20s, 5 ~ 8 parts of wheys are taken
Protein isolate is warming up to 60 ~ 70 DEG C and is stirred 30 ~ 40min, obtains mixture, takes mixture in mass ratio 15 ~ 18：30~40：
40 ~ 50 are added linseed oil, camellia oil, are stirred 1 ~ 3h in 70 ~ 90 DEG C, obtain makeup removing breast base-material.
Moisturizing repairing activity agent：
（1）Take Aspergillus oryzae lipase in mass ratio 2 ~ 4：10 ~ 15 are added the phosphate buffer that concentration is 0.05mol/L, ultrasound
20 ~ 30min, centrifugation, takes supernatant, according to the mass fraction, take 80 ~ 90 portions of supernatants, 0.3 ~ 0.5 part of conjugated linoleic acid ethyl ester,
0.3 ~ 0.6 part of Tween-80,7 ~ 10 parts of dehydrated alcohols obtain oscillation liquid, take vibration in 150r/min, 20 ~ 25 DEG C of 15 ~ 20min of oscillation
Swing liquid in mass ratio 100 ~ 120：3 ~ 5 are added macroreticular resin, are warming up to 30 ~ 35 DEG C of 5 ~ 8h of heat preservation, filter, and take and filter slag rotation steaming
Hair, freeze-drying, obtains freeze-drying object；
（2）According to the mass fraction, 1 ~ 3 part of freeze-drying object, 20 ~ 30 parts of n-hexanes, 5 ~ 9 parts of conjugated linoleic acid ethyl esters, 7 ~ 9 parts are taken
Lecithin is stirred 24 ~ 28h in 50 ~ 55 DEG C, stands 3 ~ 6h, then instill the conjugated linoleic acid second of lecithin quality 40 ~ 50%
Ester, keeps the temperature 18 ~ 20h, enzyme deactivation, and centrifugation takes supernatant rotary evaporation, obtains rotary evaporation object, rotary evaporation object in mass ratio 1 ~ 3：8
~ 10 are added acetone, and centrifugation takes precipitating vacuum distillation to get moisturizing repairing activity agent.
Cutin protection activity agent：Take ursolic acid in mass ratio 2 ~ 5：1 ~ 3 be added glycyrrhizic acid mixing to get.
Smooth skin activating agent：Take carboxymethyl yeast dextran in mass ratio 1 ~ 3：2~5：1 ~ 3 is added ascorbic acid methyl
Silanol pectate, Maca extract mixing to get.
Anticorrosive additive：Take lactobacillus peptide in mass ratio 3 ~ 6：1 ~ 3 be added ginkgo biloba p.e mixing to get.
A kind of preparation method of mild makeup removing breast, includes the following steps：
Unloading adornment oil-based material in mass ratio 10 ~ 20：1 ~ 3 is added polyglycerol polyricinoleate, is warming up to 70 ~ 80 DEG C and is stirred
30 ~ 50min obtains mixed liquor a, according to the mass fraction, takes 2 ~ 5 parts of moisturizing repairing activity agent, 1 ~ 4 part of agent of cutin protection activity, 1 ~ 3
The smooth skin activating agent of part, 0.3 ~ 0.6 part of anticorrosive additive, 30 ~ 50 parts of glycerine, are stirred 40 ~ 50min in 35 ~ 40 DEG C,
Mixed liquor b is obtained, mixed liquor b in mass ratio 8 ~ 10 is taken：2 ~ 5 are added mixed liquor a, are stirred 20 ~ 30min, 3 ~ 5min of homogeneous, i.e.,
Obtain mild makeup removing breast.
Aspergillus oryzae lipase：Enzyme activity is 100000 U/g；Macroreticular resin：D4020 adsorbs resin, and monomer is divinylbenzene.
Makeup removing breast base-material：According to the mass fraction, 3 parts of lauryl sodium sulfate, 2 parts of Tween-20s, 5 portions of whey separation eggs are taken
It is white, it is warming up to 60 DEG C and is stirred 30min, obtain mixture, take mixture in mass ratio 15：30：40 are added linseed oil, camellia
Oil is stirred 1h in 70 DEG C, obtains makeup removing breast base-material.
Moisturizing repairing activity agent：
（1）Take Aspergillus oryzae lipase in mass ratio 2：The phosphate buffer that 10 addition concentration are 0.05mol/L, ultrasonic 20min,
Centrifugation, takes supernatant, according to the mass fraction, take 80 portions of supernatants, 0.3 part of conjugated linoleic acid ethyl ester, 0.3 part of Tween-80,7 parts
Dehydrated alcohol obtains oscillation liquid in 150r/min, 20 DEG C of oscillation 15min, takes oscillation liquid in mass ratio 100：3 are added macroreticular resin,
30 DEG C of heat preservation 5h are warming up to, are filtered, takes and filters slag rotary evaporation, freeze-drying obtains freeze-drying object；
（2）According to the mass fraction, 1 part of freeze-drying object, 20 parts of n-hexanes, 5 parts of conjugated linoleic acid ethyl esters, 7 parts of lecithin are taken, in
50 DEG C are stirred for 24 hours, stand 3h, then instill the conjugated linoleic acid ethyl ester of lecithin quality 40%, keep the temperature 18h, and enzyme deactivation is centrifuged,
Supernatant rotary evaporation is taken, rotary evaporation object, rotary evaporation object in mass ratio 1 are obtained：8 are added acetone, and centrifugation takes precipitating decompression to steam
It evaporates to get moisturizing repairing activity agent.
Cutin protection activity agent：Take ursolic acid in mass ratio 2：1 be added glycyrrhizic acid mixing to get.
Smooth skin activating agent：Take carboxymethyl yeast dextran in mass ratio 1：2：1 is added ascorbic acid methyl-monosilane alcohol
Pectate, Maca extract mixing to get.
Anticorrosive additive：Take lactobacillus peptide in mass ratio 3：1 be added ginkgo biloba p.e mixing to get.
A kind of preparation method of mild makeup removing breast, includes the following steps：
Unloading adornment oil-based material in mass ratio 10：1 is added polyglycerol polyricinoleate, is warming up to 70 DEG C and is stirred 30min, obtains
Mixed liquor a, according to the mass fraction, take 2 parts of moisturizing repairing activity agent, 1 part of cutin protection activity agent, 1 portion of smooth skin activating agent,
0.3 part of anticorrosive additive, 30 parts of glycerine, are stirred 40min in 35 DEG C, obtain mixed liquor b, take mixed liquor b in mass ratio 8：2
Mixed liquor a is added, is stirred 20min, homogeneous 3min is to get mild makeup removing breast.
Aspergillus oryzae lipase：Enzyme activity is 100000 U/g；Macroreticular resin：D4020 adsorbs resin, and monomer is divinylbenzene.
Makeup removing breast base-material：According to the mass fraction, 5 parts of lauryl sodium sulfate, 6 parts of Tween-20s, 8 portions of whey separation eggs are taken
It is white, it is warming up to 70 DEG C and is stirred 40min, obtain mixture, take mixture in mass ratio 18：40：50 are added linseed oil, camellia
Oil is stirred 3h in 90 DEG C, obtains makeup removing breast base-material.
Moisturizing repairing activity agent：
（1）Take Aspergillus oryzae lipase in mass ratio 4：The phosphate buffer that 15 addition concentration are 0.05mol/L, ultrasonic 30min,
Centrifugation, takes supernatant, according to the mass fraction, take 90 portions of supernatants, 0.5 part of conjugated linoleic acid ethyl ester, 0.6 part of Tween-80,10 parts
Dehydrated alcohol obtains oscillation liquid in 150r/min, 25 DEG C of oscillation 20min, takes oscillation liquid in mass ratio 120：5 are added macroreticular resin,
35 DEG C of heat preservation 8h are warming up to, are filtered, takes and filters slag rotary evaporation, freeze-drying obtains freeze-drying object；
（2）According to the mass fraction, 3 parts of freeze-drying objects, 30 parts of n-hexanes, 9 parts of conjugated linoleic acid ethyl esters, 9 parts of lecithin are taken, in
55 DEG C are stirred 28h, stand 6h, then instill the conjugated linoleic acid ethyl ester of lecithin quality 50%, keep the temperature 20h, and enzyme deactivation is centrifuged,
Supernatant rotary evaporation is taken, rotary evaporation object, rotary evaporation object in mass ratio 3 are obtained：10 are added acetone, and centrifugation takes precipitating to depressurize
Distillation is to get moisturizing repairing activity agent.
Cutin protection activity agent：Take ursolic acid in mass ratio 5：3 be added glycyrrhizic acids mixing to get.
Smooth skin activating agent：Take carboxymethyl yeast dextran in mass ratio 3：5：3 are added ascorbic acid methyl-monosilane alcohol
Pectate, Maca extract mixing to get.
Anticorrosive additive：Take lactobacillus peptide in mass ratio 6：3 be added ginkgo biloba p.es mixing to get.
A kind of preparation method of mild makeup removing breast, includes the following steps：
Unloading adornment oil-based material in mass ratio 20：3 are added polyglycerol polyricinoleate, are warming up to 80 DEG C and are stirred 50min, obtain
Mixed liquor a, according to the mass fraction, take 5 parts of moisturizing repairing activity agent, 4 parts of cutin protection activity agent, 3 portions of smooth skin activating agents,
0.6 part of anticorrosive additive, 50 parts of glycerine, are stirred 50min in 40 DEG C, obtain mixed liquor b, take mixed liquor b in mass ratio 10：
5 are added mixed liquor a, are stirred 30min, homogeneous 5min is to get mild makeup removing breast.
Aspergillus oryzae lipase：Enzyme activity is 100000 U/g；Macroreticular resin：D4020 adsorbs resin, and monomer is divinylbenzene.
Makeup removing breast base-material：According to the mass fraction, 4 parts of lauryl sodium sulfate, 5 parts of Tween-20s, 7 portions of whey separation eggs are taken
It is white, it is warming up to 65 DEG C and is stirred 35min, obtain mixture, take mixture in mass ratio 17：35：45 are added linseed oil, camellia
Oil is stirred 2h in 75 DEG C, obtains makeup removing breast base-material.
Moisturizing repairing activity agent：
（1）Take Aspergillus oryzae lipase in mass ratio 3：The phosphate buffer that 11 addition concentration are 0.05mol/L, ultrasonic 25min,
Centrifugation, takes supernatant, according to the mass fraction, take 85 portions of supernatants, 0.4 part of conjugated linoleic acid ethyl ester, 0.5 part of Tween-80,9 parts
Dehydrated alcohol obtains oscillation liquid in 150r/min, 23 DEG C of oscillation 17min, takes oscillation liquid in mass ratio 105：4 are added macroreticular resin,
33 DEG C of heat preservation 7h are warming up to, are filtered, takes and filters slag rotary evaporation, freeze-drying obtains freeze-drying object；
（2）According to the mass fraction, 2 parts of freeze-drying objects, 25 parts of n-hexanes, 7 parts of conjugated linoleic acid ethyl esters, 8 parts of lecithin are taken, in
53 DEG C are stirred 26h, stand 5h, then instill the conjugated linoleic acid ethyl ester of lecithin quality 45%, keep the temperature 19h, and enzyme deactivation is centrifuged,
Supernatant rotary evaporation is taken, rotary evaporation object, rotary evaporation object in mass ratio 2 are obtained：9 are added acetone, and centrifugation takes precipitating decompression to steam
It evaporates to get moisturizing repairing activity agent.
Cutin protection activity agent：Take ursolic acid in mass ratio 3：2 be added glycyrrhizic acids mixing to get.
Smooth skin activating agent：Take carboxymethyl yeast dextran in mass ratio 2：3：2 are added ascorbic acid methyl-monosilane alcohol
Pectate, Maca extract mixing to get.
Anticorrosive additive：Take lactobacillus peptide in mass ratio 4：2 be added ginkgo biloba p.es mixing to get.
A kind of preparation method of mild makeup removing breast, includes the following steps：
Unloading adornment oil-based material in mass ratio 15：2 are added polyglycerol polyricinoleate, are warming up to 75 DEG C and are stirred 35min, obtain
Mixed liquor a, according to the mass fraction, take 3 parts of moisturizing repairing activity agent, 3 parts of cutin protection activity agent, 2 portions of smooth skin activating agents,
0.4 part of anticorrosive additive, 40 parts of glycerine, are stirred 45min in 37 DEG C, obtain mixed liquor b, take mixed liquor b in mass ratio 9：4
Mixed liquor a is added, is stirred 25min, homogeneous 4min is to get mild makeup removing breast.
Comparative example 1：It is essentially identical with the preparation method of embodiment 2, it has only the difference is that lacking makeup removing oil-based material.
Comparative example 2：It is essentially identical with the preparation method of embodiment 2, it has only the difference is that lacking moisturizing repairing activity agent.
Comparative example 3：The makeup removing breast of company of Wenzhou City production.
The mild makeup removing breast of above-described embodiment and comparative example is detected respectively, makeup removing effect test：Each sample
10 testers are chosen, the mild makeup removing breast in the various embodiments described above and comparative example is used for the removal of facial color make-up, are recorded
The use of tester is fed back, and makeup removing test result is shown in Table 1, stimulation test：Each sample chooses 10 testers, by above-mentioned each reality
The solution that the makeup remover in example and comparative example is diluted to 10% is applied, solution will be tested, 2 left eyes for dripping to tester are added dropwise, will disappeared
2 right eyes for dripping to tester are added dropwise in the deionized water of poison.The dropwise addition that eyes are completed in 15 seconds, records the feedback of tester, tests
It the results are shown in Table 2.Obtain that the results are shown in Table 1.
Table 1：Makeup removing effect test result
| Detection project | Embodiment 1 | Embodiment 2 | Embodiment 3 | Comparative example 1 | Comparative example 2 | Comparative example 3 |
| Makeup removing effect is fine | 8 people | 10 people | 9 people | 6 people | 7 people | 6 people |
| Makeup removing effect is general | 2 people | 0 people | 1 people | 3 people | 3 people | 2 people |
| Makeup removing effect is bad | 0 people | 0 people | 0 people | 1 people | 0 people | 2 people |
Table 2：Stimulation test result
| Detection project | Embodiment 1 | Embodiment 2 | Embodiment 3 | Comparative example 1 | Comparative example 2 | Comparative example 3 |
| It is non-stimulated | 9 people | 10 people | 9 people | 7 people | 5 people | 0 people |
| Mildly（Minimal irritation） | 1 people | 0 people | 1 people | 3 people | 4 people | 2 people |
| Medium stimulation（It can endure） | 0 people | 0 people | 0 people | 0 people | 1 people | 7 people |
| Serious stimulation（It can not endure） | 0 people | 0 people | 0 people | 0 people | 0 people | 1 people |
In summary, mild makeup removing breast effect of the invention is more preferable, is worth of widely use.
Claims (7)
1. a kind of mild makeup removing breast, including the agent of cutin protection activity, smooth skin activating agent, anticorrosive additive, feature exist
In, further include makeup removing oil-based material, moisturizing repairing activity agent；
The preparation method of the makeup removing breast base-material, includes the following steps：
According to the mass fraction, 3 ~ 5 parts of lauryl sodium sulfate, 2 ~ 6 parts of Tween-20s, 5 ~ 8 parts of whey protein isolates are taken, are warming up to
60 ~ 70 DEG C are stirred, and obtain mixture, take mixture in mass ratio 15 ~ 18：30~40：40 ~ 50 are added linseed oil, camellia oil
It is stirred, obtains makeup removing breast base-material.
2. mild makeup removing breast according to claim 1, which is characterized in that it is described linseed oil is added, camellia oil stirs
Mix mixing condition：1 ~ 3h is stirred in 70 ~ 90 DEG C.
3. mild makeup removing breast according to claim 1, which is characterized in that the moisturizing repairing activity agent：（1）Take meter Qu
Mould lipase in mass ratio 2 ~ 4：10 ~ 15 are added phosphate buffer, 20 ~ 30min of ultrasound, and centrifugation takes supernatant, by mass parts
Number meter, takes 80 ~ 90 portions of supernatants, 0.3 ~ 0.5 part of conjugated linoleic acid ethyl ester, 0.3 ~ 0.6 part of Tween-80,7 ~ 10 parts of dehydrated alcohols,
In 150r/min, 20 ~ 25 DEG C of 15 ~ 20min of oscillation, oscillation liquid is obtained, takes oscillation liquid in mass ratio 100 ~ 120：3 ~ 5 are added macropore tree
Rouge is warming up to 30 ~ 35 DEG C of heat preservations, filters, and takes and filters slag rotary evaporation, and freeze-drying obtains freeze-drying object；
（2）According to the mass fraction, 1 ~ 3 part of freeze-drying object, 20 ~ 30 parts of n-hexanes, 5 ~ 9 parts of conjugated linoleic acid ethyl esters, 7 ~ 9 parts are taken
Lecithin is stirred in 50 ~ 55 DEG C, is stood, then instill the conjugated linoleic acid ethyl ester of lecithin quality 40 ~ 50%, and heat preservation 18 ~
20h, enzyme deactivation, centrifugation take supernatant rotary evaporation, obtain rotary evaporation object, rotary evaporation object in mass ratio 1 ~ 3：8 ~ 10 are added third
Ketone, centrifugation take precipitating vacuum distillation to get moisturizing repairing activity agent.
4. mild makeup removing breast according to claim 1, which is characterized in that the cutin protection activity agent：Take ursolic acid
In mass ratio 2 ~ 5：1 ~ 3 be added glycyrrhizic acid mixing to get.
5. mild makeup removing breast according to claim 1, which is characterized in that the smooth skin activating agent：Take carboxymethyl
Yeast dextran in mass ratio 1 ~ 3：2~5：1 ~ 3 is added ascorbic acid methyl-monosilane alcohol pectate, the mixing of Maca extract, i.e.,
?.
6. mild makeup removing breast according to claim 1, which is characterized in that the anticorrosive additive：Take lactobacillus peptide by
Mass ratio 3 ~ 6：1 ~ 3 be added ginkgo biloba p.e mixing to get.
7. a kind of preparation method of the mild makeup removing breast as described in claim 1 ~ 6 any one, which is characterized in that the preparation
Method includes the following steps：
Unloading adornment oil-based material in mass ratio 10 ~ 20：1 ~ 3 is added polyglycerol polyricinoleate, and it is mixed to be warming up to 70 ~ 80 DEG C of stirrings
Close, obtain mixed liquor a, according to the mass fraction, take 2 ~ 5 parts of moisturizing repairing activity agent, 1 ~ 4 part of cutin protection activity agent, 1 ~ 3 part it is smooth
Skin activating agent, 0.3 ~ 0.6 part of anticorrosive additive, 30 ~ 50 parts of glycerine, are stirred in 35 ~ 40 DEG C, obtain mixed liquor b, take mixed
Close liquid b in mass ratio 8 ~ 10：5 ~ 7 addition mixed liquor a are stirred, and homogeneous is to get mild makeup removing breast.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811014811.1A CN108852890A (en) | 2018-08-31 | 2018-08-31 | A kind of mild makeup removing breast and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811014811.1A CN108852890A (en) | 2018-08-31 | 2018-08-31 | A kind of mild makeup removing breast and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108852890A true CN108852890A (en) | 2018-11-23 |
Family
ID=64323010
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811014811.1A Pending CN108852890A (en) | 2018-08-31 | 2018-08-31 | A kind of mild makeup removing breast and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108852890A (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102271652A (en) * | 2009-02-20 | 2011-12-07 | 株式会社和一药品 | Aqueous nanoemulsion composition containing conjugated linoleic acid |
| CN103202775A (en) * | 2013-03-25 | 2013-07-17 | 上海应用技术学院 | Double-layer cleansing lotion and preparation method thereof |
| CN105997580A (en) * | 2016-05-18 | 2016-10-12 | 广州丹奇日用化工厂有限公司 | Skin-care cleansing oil and preparation method thereof |
-
2018
- 2018-08-31 CN CN201811014811.1A patent/CN108852890A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102271652A (en) * | 2009-02-20 | 2011-12-07 | 株式会社和一药品 | Aqueous nanoemulsion composition containing conjugated linoleic acid |
| CN103202775A (en) * | 2013-03-25 | 2013-07-17 | 上海应用技术学院 | Double-layer cleansing lotion and preparation method thereof |
| CN105997580A (en) * | 2016-05-18 | 2016-10-12 | 广州丹奇日用化工厂有限公司 | Skin-care cleansing oil and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4099173B2 (en) | Cosmetic or dermopharmaceutical composition comprising kombucha | |
| JP3502990B2 (en) | Method for separating compounds containing plant-derived glycolipid, lysophospholipid, sphingolipid, ceramide | |
| DE4401308C2 (en) | Cosmetic agent with anti-cellulite effect | |
| DE4021082C2 (en) | High lipid-containing skin treatment agent using a bilayer-containing system, organic acid salts, alcohol and stabilizer | |
| JP2023519484A (en) | Method for obtaining collagen peptide from starfish, elastic liposome containing starfish-derived collagen peptide, and cosmetic composition containing the same | |
| KR20070081192A (en) | Cosmetic compostion comprising liposome incorporating oryzanol, rice bran oil and phospholipid | |
| KR101572155B1 (en) | Method of Manufacturing Natural Cosmetic Composition Containing the extract of Moringa oleifera | |
| WO2016195142A1 (en) | Method for producing natural nanoemulsion cosmetic composition containing moringa extract | |
| CN106413681A (en) | Ceramide-formulated external agent composition | |
| WO2000030602A1 (en) | Oil bodies as topical delivery vehicles for active agents | |
| CN108852890A (en) | A kind of mild makeup removing breast and preparation method thereof | |
| KR100490365B1 (en) | Cosmetics including nanovesicle | |
| CN105997609B (en) | A kind of moisture-keeping composition and preparation method thereof | |
| KR20170069661A (en) | Natural liposome comprising colagen and hyaluronic acid, peocess for the preparation thereof, and cosmetic composition comprising the same | |
| RU2277954C2 (en) | Rejuvenating face cream | |
| RU2240782C1 (en) | Method for preparing emulsion cosmetic agent | |
| US20030170333A1 (en) | Cosmetic base complex | |
| US11478418B2 (en) | Fat and/or wax activated by means of the water-insoluble fraction of Carica papaya sap | |
| KR101702482B1 (en) | Cosmetic composition providing nano liposome with skin immune, sterilizing power and absortive and manufacturing the same | |
| JPS62286907A (en) | Production of cosmetic or bathing agent | |
| KR20150096165A (en) | Manufacturing method for cosmetic composition for improving acne and cosmetic compostion thereof | |
| JP5913479B2 (en) | Composition for promoting hair growth comprising human growth hormone as an active ingredient | |
| TWI792052B (en) | Skin care savon within flower extration carrier amino acid peptide base formulation for cleaning, skin moisturizing and repairing, and cosmetics and skin care product thereof | |
| WO2022004632A1 (en) | Hair growth and/or hair restoration composition | |
| RU2200001C2 (en) | Cream for skin |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WD01 | Invention patent application deemed withdrawn after publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20181123 |