CN108851091A - Antimicrobial peptide protein effervescent tablet and preparation method thereof - Google Patents
Antimicrobial peptide protein effervescent tablet and preparation method thereof Download PDFInfo
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- CN108851091A CN108851091A CN201810398580.2A CN201810398580A CN108851091A CN 108851091 A CN108851091 A CN 108851091A CN 201810398580 A CN201810398580 A CN 201810398580A CN 108851091 A CN108851091 A CN 108851091A
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- antimicrobial peptide
- peptide protein
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- protein
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- 108090000623 proteins and genes Proteins 0.000 title claims abstract description 54
- 102000004169 proteins and genes Human genes 0.000 title claims abstract description 54
- 239000003910 polypeptide antibiotic agent Substances 0.000 title claims abstract description 51
- 108700042778 Antimicrobial Peptides Proteins 0.000 title claims abstract description 45
- 102000044503 Antimicrobial Peptides Human genes 0.000 title claims abstract description 45
- 239000007938 effervescent tablet Substances 0.000 title claims abstract description 28
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 239000000843 powder Substances 0.000 claims abstract description 33
- 239000000203 mixture Substances 0.000 claims abstract description 14
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims abstract description 13
- 239000003513 alkali Substances 0.000 claims abstract description 13
- 235000005911 diet Nutrition 0.000 claims abstract description 13
- 230000000378 dietary effect Effects 0.000 claims abstract description 13
- 235000007983 food acid Nutrition 0.000 claims abstract description 13
- 239000008101 lactose Substances 0.000 claims abstract description 13
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims abstract description 10
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims abstract description 10
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims abstract description 10
- 239000002202 Polyethylene glycol Substances 0.000 claims abstract description 8
- 229920001223 polyethylene glycol Polymers 0.000 claims abstract description 8
- 235000003599 food sweetener Nutrition 0.000 claims abstract description 7
- 239000000463 material Substances 0.000 claims abstract description 7
- 239000003765 sweetening agent Substances 0.000 claims abstract description 7
- 239000000853 adhesive Substances 0.000 claims abstract description 6
- 230000001070 adhesive effect Effects 0.000 claims abstract description 6
- 238000001035 drying Methods 0.000 claims abstract description 6
- 239000000314 lubricant Substances 0.000 claims abstract description 6
- 238000005469 granulation Methods 0.000 claims abstract description 4
- 230000003179 granulation Effects 0.000 claims abstract description 4
- 239000002245 particle Substances 0.000 claims abstract description 4
- 238000000748 compression moulding Methods 0.000 claims abstract description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 12
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 12
- 241001481656 Stratiomyidae Species 0.000 claims description 9
- CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 9
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 8
- 239000012460 protein solution Substances 0.000 claims description 8
- 239000000243 solution Substances 0.000 claims description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 239000012153 distilled water Substances 0.000 claims description 6
- 239000006228 supernatant Substances 0.000 claims description 6
- 239000002253 acid Substances 0.000 claims description 5
- 235000010323 ascorbic acid Nutrition 0.000 claims description 5
- 239000011668 ascorbic acid Substances 0.000 claims description 5
- 229960005070 ascorbic acid Drugs 0.000 claims description 5
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 4
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 4
- 235000015165 citric acid Nutrition 0.000 claims description 4
- 235000011090 malic acid Nutrition 0.000 claims description 4
- 239000001630 malic acid Substances 0.000 claims description 4
- 238000000034 method Methods 0.000 claims description 4
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 4
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 4
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 3
- 238000003756 stirring Methods 0.000 claims description 3
- 235000019605 sweet taste sensations Nutrition 0.000 claims description 3
- 238000011034 membrane dialysis Methods 0.000 claims description 2
- 229910052976 metal sulfide Inorganic materials 0.000 claims description 2
- -1 polyethylene Pyrrolidones Polymers 0.000 claims description 2
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims 1
- 229930003268 Vitamin C Natural products 0.000 claims 1
- 235000019154 vitamin C Nutrition 0.000 claims 1
- 239000011718 vitamin C Substances 0.000 claims 1
- 239000006260 foam Substances 0.000 abstract description 3
- 230000007547 defect Effects 0.000 abstract description 2
- 238000004080 punching Methods 0.000 abstract description 2
- 235000018102 proteins Nutrition 0.000 description 34
- 241000238631 Hexapoda Species 0.000 description 21
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 238000011160 research Methods 0.000 description 5
- 239000008118 PEG 6000 Substances 0.000 description 4
- 229920002584 Polyethylene Glycol 6000 Polymers 0.000 description 4
- 238000004090 dissolution Methods 0.000 description 4
- 239000002585 base Substances 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 235000012907 honey Nutrition 0.000 description 3
- 241000255789 Bombyx mori Species 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241000254109 Tenebrio molitor Species 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 230000007071 enzymatic hydrolysis Effects 0.000 description 2
- 238000006047 enzymatic hydrolysis reaction Methods 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 230000000050 nutritive effect Effects 0.000 description 2
- 241000931705 Cicada Species 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 241001516928 Kerria lacca Species 0.000 description 1
- 241000254022 Locusta migratoria Species 0.000 description 1
- 206010054949 Metaplasia Diseases 0.000 description 1
- 241001516602 Schlechtendalia chinensis Species 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- 241001122767 Theaceae Species 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 235000021120 animal protein Nutrition 0.000 description 1
- 230000002929 anti-fatigue Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 238000009360 aquaculture Methods 0.000 description 1
- 244000144974 aquaculture Species 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 235000012055 fruits and vegetables Nutrition 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 230000015689 metaplastic ossification Effects 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000000751 protein extraction Methods 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/385—Concentrates of non-alcoholic beverages
- A23L2/39—Dry compositions
- A23L2/395—Dry compositions in a particular shape or form
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/40—Effervescence-generating compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Polymers & Plastics (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention discloses a kind of antimicrobial peptide protein effervescent tablets, including following weight percentage components：Antimicrobial peptide protein powder 10-20%, food acids 10-20%, dietary alkali 10-15%, lactose 20-30%, edible essence 1-4%, sweetener 0.5-2%, polyvinylpyrrolidone 2-4%, polyethylene glycol 1.5-4%；The present invention also provides above-mentioned antimicrobial peptide protein effervesce piece preparation methods, include the following steps：It is spare by being sieved with 100 mesh sieve respectively after antimicrobial peptide protein powder and the drying of all auxiliary materials；It is uniformly mixed after antimicrobial peptide protein powder is pulverized and sieved with lactose with equivalent gradually-increased；Mixture is divided into two parts, food acids and edible essence is added in portion, and sweetener and dietary alkali is added in another；Two parts of mixtures are separately added into adhesive, it is dry after granulation；Particle is mixed, by 16 mesh sieves, compression molding after lubricant is then added.For the present invention under the premise of improving antibacterial peptide effervescent tablet activated protein content, conspicuousness overcomes the glutinous punching occurred during disintegration, disintegration time length, the defect for being also easy to produce the Character instabilities such as foam.
Description
Technical field
The present invention relates to health product technology field, in particular to a kind of albumen effervescent tablet and preparation method thereof.
Background technique
With socio-economic development, the people are higher and higher to the health care product demand in health care and novel foodstuff source.Money
Insect is not only many kinds of in source, but also has the characteristics that population quantity is big, reproductive capacity is strong, wide adaptability, can be used as a kind of heavy
The living resources wanted are mankind's service, and from the point of view of developing the purposes of insect resources at this stage, the research on utilization of insect resources is substantially
There is edible insect（Black soldier flies, yellow meal worm, locust, silkworm chrysalis etc.）, feed insect, pharmaceutical insects（Ant, cicada）, raw material of industry insect
（Silkworm, wax insect, lac insect, melaphis chinensis Baker etc.）, natural enemy insect, ornamental amusement insect, insect pollinator, scavenger insect, insect it is raw
In terms of 10 researchs such as object reactor and insect are bionical.
Protein rich in, is important animal protein sources in insect bodies.As the mankind are food-safe important
Property understanding deepen continuously, the research of edible insect gradually increases, and a small number of edible insect artificial culture technologies are more mature, such as east
Sub- migratory locusts, yellow meal worm etc..To some tradition not directly edible insect, such as fly maggot, stratiomyiid, since it can convert excrement of animals
And rubbish, play a significant role in environmental protection and circular agriculture, has also carried out artificial culture technology, Protein Extraction, product and added
The research and application of work etc., but product is utilized mainly as animal feed.
Black soldier flies are a kind of emerging resource insects, and ecologic adaptation ability is strong, and distributional region is wide, and have quite high battalion
Value is supported, the constituent contents such as protein, grease and selenium, iron are rich and varied, and manufactured goods have anti-oxidant, antifatigue effect,
Also there is certain preventive and therapeutic action to hypertension.Black soldier flies are as a kind of high protein insect at present in terms of feed, raising
Using more, in food processing field also in the initial stage, since black soldier flies are easy for workers to breed, and nutritive value is high,
Become a kind of protein resource of great exploitation potential.
Novel black soldier flies antimicrobial peptide protein effervescent tablet is developed, the development of resource insect aquaculture industry is not only contributed to, is expanded
Big food source range, to meet the needs of people are to novel foodstuff and health care product, and with easy to carry, Instant Drinks are easily significant
Advantage.Effervescent tablet is reacted after being contacted using soda acid, have meet water fater disintegration, release rapidly, in vivo infiltration rate it is fast,
The high feature of bioavilability.Effervescent tablet also has relatively broad application in field of food, such as effervescent tea tablet, fruits and vegetables effervesce
Piece, vitamin effervescent tablet etc..It is domestic at present less for the research of antimicrobial peptide protein class effervescent tablet.
Summary of the invention
In view of this, the purpose of the present invention is to provide a kind of antimicrobial peptide protein effervescent tablets.
In order to achieve the above objectives, the present invention provides the following technical solutions：
Antimicrobial peptide protein effervescent tablet, including following weight percentage components：Antimicrobial peptide protein powder 10-20%, food acids 10-
20%, dietary alkali 10-15%, lactose 20-30%, edible essence 1-4%, sweetener 0.5-2%, polyvinylpyrrolidone 2-4%,
Polyethylene glycol 1.5-4%.
The present invention also provides above-mentioned antimicrobial peptide protein effervesce piece preparation methods, include the following steps：
1）It is spare by being sieved with 100 mesh sieve respectively after antimicrobial peptide protein powder and auxiliary material drying；
2）It is uniformly mixed after antimicrobial peptide protein powder is pulverized and sieved with lactose with equivalent gradually-increased；
3）By step 2）The mixture of acquisition is divided into two parts, and food acids and edible essence is added in portion, and sweet taste is added in another
Agent and dietary alkali；
4）By step 3）The two parts of mixtures obtained are separately added into adhesive, dry after granulation；
5）By step 4）The particle of acquisition mixes, and by 16 mesh sieves, compression molding after lubricant is then added.
Further, the step 1）In antimicrobial peptide protein powder be prepared via a method which：
11）Black soldier flies five ages fresh worm is taken, is smashed as fresh worm powder；
12）Fresh worm powder is digested, protein solution is obtained；
13）By step 12）The protein solution of acquisition is dry, obtains albumen powder.
Further, the step 11）In, black soldier flies five ages fresh worm is taken, 20 meshes are smashed it through.
Further, described 12）In, fresh worm powder is taken, ascorbic acid, trypsase and distilled water is added, adjusts pH value to 7.0,35
DEG C water-bath is protected from light stirring 3h, filters, obtains enzymatic hydrolysis supernatant；It is the semi-transparent of 7000Dalton that supernatant, which will be digested, with molecular cut off
Film dialysis 2h, collects dialyzate, obtains the protein solution rich in antibacterial peptide.
Further, the materials ratio of the fresh worm powder ascorbic acid, trypsase and distilled water is 20g：0.2g：0.2g：
300ml。
Further, the step 3）In, food acids be citric acid and malic acid mixture, dietary alkali be sodium bicarbonate and
The mixture of sodium carbonate；Step 4）In, adhesive is polyvinylpyrrolidone ethanol solution；Step 5）In, lubricant is poly- second
Glycol.
Further, step 2）It later further include step 3）：By step 2）The metal sulfide of preparation takes out, rinsing, drying.
Further, the antimicrobial peptide protein effervescent tablet includes following weight percentage components：Antimicrobial peptide protein powder 10-
20%, food acids 10-20%, dietary alkali 10-15%, lactose 20-30%, edible essence 1-4%, sweetener 0.5-2%, polyethylene
Pyrrolidones 2-4%, polyethylene glycol 1.5-4%.
The beneficial effects of the present invention are：Antimicrobial peptide protein effervescent tablet of the invention and preparation method thereof is improving antibacterial
Under the premise of peptide effervescent tablet activated protein content, conspicuousness overcomes the glutinous punching occurred during disintegration, disintegration time length, is also easy to produce
The defect of the Character instabilities such as foam.The innovative character with change effervescent tablet, while increasing specific surface area to realize product
Disintegration after stability, effectively shorten the disintegration time of effervescent tablet, avoid foam and strength in disintegrating procedue and rush phenomenon
It generates.It is short using antibacterial peptide effervescent tablet dissolution time obtained by preparation method of the present invention, antibacterial activity and egg can be given full play to
White nutritive value has using the features such as easy, stability is good, is suitble to various quick consumer groups, can satisfy industry completely
The demand that metaplasia produces.
Specific embodiment
A preferred embodiment of the present invention will be described in detail below, but illustrated embodiment is not as to of the invention
It limits.Test method without specific conditions in preferred embodiment, usually according to normal condition, or according to reagent manufacturer
Proposed condition carries out.
Antimicrobial peptide protein effervescent tablet, including following weight percentage components：Antimicrobial peptide protein powder 10-20%, food acids
10-20%, dietary alkali 10-15%, lactose 20-30%, edible essence 1-4%, sweetener 0.5-2%, polyvinylpyrrolidone 2-
4%, polyethylene glycol 1.5-4%.
The antimicrobial peptide protein powder is prepared via a method which：
11）Black soldier flies five ages fresh worm is taken, 20 meshes are smashed it through；
12）Fresh worm powder is taken, ascorbic acid, trypsase and distilled water is added, pH value to 7.0,35 DEG C of water-baths is adjusted and is protected from light stirring
3h filters, obtains enzymatic hydrolysis supernatant；The semi-permeable membrane dialysis 2h that supernatant is 7000Dalton with molecular cut off will be digested, will be collected
Dialyzate obtains the protein solution rich in antibacterial peptide.The materials ratio of the fresh worm powder ascorbic acid, trypsase and distilled water
For 20g：0.2g：0.2g：300ml；
13）By step 12）The protein solution of acquisition is dry, obtains albumen powder.
The present invention also provides above-mentioned antimicrobial peptide protein effervesce piece preparation methods, include the following steps：
1）It is spare by being sieved with 100 mesh sieve respectively after antimicrobial peptide protein powder and auxiliary material drying；
2）It is uniformly mixed after antimicrobial peptide protein powder is pulverized and sieved with lactose with equivalent gradually-increased；
3）By step 2）The mixture of acquisition is divided into two parts, and food acids and edible essence is added in portion, and sweet taste is added in another
Agent and dietary alkali；Food acids are the mixture of citric acid and malic acid（The ratio of citric acid and malic acid is 3：2）, dietary alkali is
The mixture of sodium bicarbonate and sodium carbonate（The weight percent of sodium bicarbonate and sodium carbonate is 7：1）；
4）By step 3）The two parts of mixtures obtained are separately added into the polyvinylpyrrolidone ethanol solution of adhesive 10%, granulation
After dry；
5）By step 4）The particle of acquisition mixes, and by 16 mesh sieves, presses after lubricant polyethylene glycol PEG6000 then is added
Sheetmolding.
Embodiment 1：Antimicrobial peptide protein effervescent tablet（Slice weight 4g）, containing following weight percentage components：Antimicrobial peptide protein
Powder 10%, mixed acid 10%, mixed base 10%, lactose 20%, edible essence 1%, honey element 0.5%, polyvinylpyrrolidone 2%,
PEG6000 2%.The protein content of obtained albumen effervescent tablet is 10%, uniform color, and complete bright and clean, hardness is in 2.07-
Between 2.27Kgf, disintegration time is less than 130s, and between solution ph 8-9, after dissolving 30min, the accumulative dissolution of protein is more than
85%。
Embodiment 2：A kind of antimicrobial peptide protein effervescent tablet（Slice weight 4g）, containing following weight percentage components：Institute
It states ingredient contained by effervescent tablet and weight is as follows：Antimicrobial peptide protein powder 15%, mixed acid 15%, mixed base 13%, lactose 25%,
Edible essence 3%, honey element 1%, polyvinylpyrrolidone 3%, PEG6000 3%.The protein of obtained albumen effervescent tablet contains
Amount is 15%, uniform color, complete bright and clean, and for hardness between 2.21-2.47Kgf, disintegration time is less than 130s, solution ph
Between 7.5-8.5, after dissolving 30min, the accumulative dissolution of protein is more than 82%.
Embodiment 3：A kind of antimicrobial peptide protein effervescent tablet（Slice weight 4g）, containing following weight percentage components：Institute
It states ingredient contained by effervescent tablet and weight is as follows：Antimicrobial peptide protein powder 20%, mixed acid 20%, mixed base 15%, lactose 30%,
Edible essence 4%, honey element 2%, polyvinylpyrrolidone 4%, PEG6000 4%.The protein of obtained albumen effervescent tablet contains
Amount is 20%, uniform color, complete bright and clean, and for hardness between 2.12-2.35Kgf, disintegration time is less than 130s, solution ph 7-8
Between, after dissolving 30min, the accumulative dissolution of protein is more than 82%.
Finally, it is stated that preferred embodiment above is only used to illustrate the technical scheme of the present invention and not to limit it, although logical
It crosses above preferred embodiment the present invention is described in detail, however, those skilled in the art should understand that, can be
Various changes are made to it in form and in details, without departing from claims of the present invention limited range.
Claims (9)
1. antimicrobial peptide protein effervescent tablet, it is characterised in that：Including following weight percentage components：Antimicrobial peptide protein powder 10-
20%, food acids 10-20%, dietary alkali 10-15%, lactose 20-30%, edible essence 1-4%, sweetener 0.5-2%, polyethylene
Pyrrolidones 2-4%, polyethylene glycol 1.5-4%.
2. antimicrobial peptide protein effervesce piece preparation method, which is characterized in that include the following steps：
1）It is spare by being sieved with 100 mesh sieve respectively after antimicrobial peptide protein powder and auxiliary material drying；
2）It is uniformly mixed after antimicrobial peptide protein powder is pulverized and sieved with lactose with equivalent gradually-increased；
3）By step 2）The mixture of acquisition is divided into two parts, and food acids and edible essence is added in portion, and sweet taste is added in another
Agent and dietary alkali；
4）By step 3）The two parts of mixtures obtained are separately added into adhesive, dry after granulation；
5）By step 4）The particle of acquisition mixes, and by 16 mesh sieves, compression molding after lubricant is then added.
3. antimicrobial peptide protein effervesce piece preparation method as claimed in claim 2, it is characterised in that：The step 1）In antibacterial
Peptide albumen powder is prepared via a method which：
11）Black soldier flies five ages fresh worm is taken, is smashed as fresh worm powder；
12）Fresh worm powder is digested, protein solution is obtained；
13）By step 12）The protein solution of acquisition is dry, obtains albumen powder.
4. antimicrobial peptide protein effervesce piece preparation method as claimed in claim 3, it is characterised in that：The step 11）In, it takes black
Stratiomyiid five ages fresh worm, smashes it through 20 meshes.
5. antimicrobial peptide protein effervesce piece preparation method as claimed in claim 4, it is characterised in that：Described 12）In, take fresh worm
Ascorbic acid, trypsase and distilled water is added in powder, adjusts pH value to 7.0,35 DEG C of water-baths and is protected from light stirring 3h, filters, must digest
Supernatant；The semi-permeable membrane dialysis 2h that supernatant is 7000Dalton with molecular cut off will be digested, dialyzate is collected, is rich in
The protein solution of antibacterial peptide.
6. antimicrobial peptide protein effervesce piece preparation method as claimed in claim 5, it is characterised in that：The fresh worm powder Vitamin C
The materials ratio of acid, trypsase and distilled water is 20g：0.2g：0.2g：300ml.
7. the antimicrobial peptide protein effervesce piece preparation method as described in any one of claim 2-6, it is characterised in that：The step
3）In, food acids are the mixture of citric acid and malic acid, and dietary alkali is the mixture of sodium bicarbonate and sodium carbonate；Step 4）
In, adhesive is polyvinylpyrrolidone ethanol solution；Step 5）In, lubricant is polyethylene glycol.
8. antimicrobial peptide protein effervesce piece preparation method as claimed in claim 7, it is characterised in that：Step 2）It later further include step
Rapid 3）：By step 2）The metal sulfide of preparation takes out, rinsing, drying.
9. antimicrobial peptide protein effervesce piece preparation method as claimed in claim 8, it is characterised in that：The antimicrobial peptide protein effervesce
Piece includes following weight percentage components：Antimicrobial peptide protein powder 10-20%, food acids 10-20%, dietary alkali 10-15%, lactose
20-30%, edible essence 1-4%, sweetener 0.5-2%, polyvinylpyrrolidone 2-4%, polyethylene glycol 1.5-4%.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112321697A (en) * | 2020-12-15 | 2021-02-05 | 天津市农业科学院 | Hermetia illucens antibacterial peptide Cecropin-alpha and application thereof |
| CN113388454A (en) * | 2021-06-09 | 2021-09-14 | 泉州师范学院 | Fishbone meal zymolyte antibacterial cleaning effervescent tablet and preparation method thereof |
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| CN102283864A (en) * | 2011-07-28 | 2011-12-21 | 陕西科技大学 | Donkey-hide gelatin effervescent tablets and preparation method thereof |
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| CN102283864A (en) * | 2011-07-28 | 2011-12-21 | 陕西科技大学 | Donkey-hide gelatin effervescent tablets and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112321697A (en) * | 2020-12-15 | 2021-02-05 | 天津市农业科学院 | Hermetia illucens antibacterial peptide Cecropin-alpha and application thereof |
| CN112321697B (en) * | 2020-12-15 | 2022-01-21 | 天津市农业科学院 | Hermetia illucens antibacterial peptide Cecropin-alpha and application thereof |
| CN113388454A (en) * | 2021-06-09 | 2021-09-14 | 泉州师范学院 | Fishbone meal zymolyte antibacterial cleaning effervescent tablet and preparation method thereof |
| CN113388454B (en) * | 2021-06-09 | 2022-12-13 | 泉州师范学院 | Fishbone meal zymolyte antibacterial cleaning effervescent tablet and preparation method thereof |
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