CN108841013A - A kind of aquagel and preparation method thereof - Google Patents

A kind of aquagel and preparation method thereof Download PDF

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Publication number
CN108841013A
CN108841013A CN201810557407.2A CN201810557407A CN108841013A CN 108841013 A CN108841013 A CN 108841013A CN 201810557407 A CN201810557407 A CN 201810557407A CN 108841013 A CN108841013 A CN 108841013A
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chitosan
breviscapinun
solution
aquagel
graphene oxide
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林前锋
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Hunan Guosheng Graphite Technology Co Ltd
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Hunan Guosheng Graphite Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0004—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0023—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/0066—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/008—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/009—Materials resorbable by the body
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/075—Macromolecular gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/23—Carbohydrates
    • A61L2300/232—Monosaccharides, disaccharides, polysaccharides, lipopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2305/00—Characterised by the use of polysaccharides or of their derivatives not provided for in groups C08J2301/00 or C08J2303/00
    • C08J2305/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K3/00—Use of inorganic substances as compounding ingredients
    • C08K3/02—Elements
    • C08K3/04—Carbon
    • C08K3/042—Graphene or derivatives, e.g. graphene oxides
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/04—Oxygen-containing compounds
    • C08K5/15—Heterocyclic compounds having oxygen in the ring
    • C08K5/151—Heterocyclic compounds having oxygen in the ring having one oxygen atom in the ring
    • C08K5/1545—Six-membered rings

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  • Engineering & Computer Science (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention belongs to biomedical material technologies, and in particular to a kind of aquagel and preparation method thereof.It is 1~2 by mass ratio:3~5:0.5~1 Breviscapinun, chitosan and graphene oxide is combined.The hydrogel passes through effective combination of Breviscapinun, chitosan and graphene oxide, it can accelerate the healing of wound, have the characteristics that hemostasis, antibacterial and inhibition cicatrization from the root, the clotting time can be shortened, accelerate wound healing and reduce the formation of scar.The hydrogel preparation method is simple and convenient, it is practical, high molecular material used is nontoxic, biodegradable material, and manufactured composite hydrogel has the advantages that good biocompatibility, biological degradability are good, absorbability is good, safe and non-toxic, has a good application prospect.

Description

A kind of aquagel and preparation method thereof
Technical field
The invention belongs to biomedical material technologies.More particularly, to a kind of aquagel and its preparation Method.
Background technique
Scar is dermis of skin fibroblast proliferation disorder, and fibroblast is caused excessively to generate, collagen over-deposit It is formed, common complication, drastically influences the appearance and psychology of patient after being skin trauma and performing the operation.The morbidity machine of scar System and its control method are always the research hotspot of medical field, there is no specific conclusion to the research of its pathogenesis at present.Scar Trace is the product of skin ultrastructure and agglutination, any in addition to the shallow wound of table can be formed by simple epithelium and be repaired Damage as deep as corium and subcutaneous tissue can all be repaired by cicatrization.Theoretically, scar once being formed, even if adopting With most fine operation method, although it is made to obtain part improvement, and cannot thoroughly eradicate.
The treatment course of scar is longer, and clinical treatment method is more at present, and excision of such as performing the operation, pressure therapy, radiation are controlled Treatment, laser therapy, optical dynamic therapy etc., but effect is also not satisfactory, and scar is easy to recur.There are also for treating for Vehicles Collected from Market The drug of scar, such as hormone medicine, anti-tumor drug, Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 inhibitor, cell factor, immunosuppressor.But these Drug price is expensive, and manufacturing process is cumbersome, and effect is different, and there are a degree of adverse reactions.
The cardinal principle of scar treatment is removal lesion, and passes through the conjunction of the fibroblastic proliferation of inhibition and its collagen At, secretion or deposits and prevent its recurrence.Breviscapinun（Breviscapine）It is from compositae plant Erigeron breviscapus（Erigeron breviscapus（Vant.）Hand. -Mazz.）Drying herb（Also known as erigeron breviscapus）The flavonoids of middle extraction effectively at Point, there is anticoagulation, antithrombus formation and promote a series of pharmacological actions such as fibrinolytic, anti-inflammatory, anti-oxidant, Antipyretic. Some researches show that Breviscapinun can inhibit fibroblastic hyper-proliferative in Process of Forming Scar, have one to cicatrization Surely the effect inhibited.But Breviscapinun antibacterial effect is bad.
Chitosan is natural marine high molecular material, has good biocompatibility, degradable, non-immunogenicity, nontoxic pair The potential advantages such as effect, abundance, at the same also have the function of well stop blooding, antibacterial and promote wound healing, hemostasis and There is good application in wound repair, wound healing can be accelerated.But natural chitosan high molecular material stability is poor.
Summary of the invention
The technical problem to be solved by the present invention is to overcome the defect of the above-mentioned prior art and deficiencies, for wound, burn, scald There are certain adverse reactions in skin trauma caused by the reasons such as wound, operation and the cicatrization therapeutic process after wound repair And the problems such as recurrence rate, provide that a kind of toxic side effect is low, can effectively inhibit the aquagel of cicatrization.The Compound Water Gel process for preparing is simple, and the hydrogel being prepared into can not only accelerate the healing of wound, and can efficiently inhibit scar Formation, fibroblastic hyper-proliferative can be inhibited in wound healing process and can induce its occur apoptosis, from the root Resist the generation of scar.
Another object of the present invention is to provide the preparation method of above-mentioned aquagel.
Another object of the present invention is to provide the aquagel and inhibits the application in cicatrization preparation in preparation.
Above-mentioned purpose of the present invention is achieved through the following technical solutions：
A kind of aquagel is 1~2 by mass ratio:3~5:0.5~1 Breviscapinun, chitosan and graphene oxide It is combined.
Preferably, the Breviscapinun, chitosan, graphene oxide mass ratio be 1.5~1.8:3.5~4.5:0.6 ~0.8.
Preferably, the molecular weight of the chitosan is 10KDa~100KDa, deacetylation is 90%~92%, the oxidation The molecular weight of graphene is 3000Da~8000Da.
Hydrogel provided by the invention passes through effective combination of Breviscapinun, chitosan and graphene oxide, can accelerate to create The healing of face wound has the characteristics that hemostasis, antibacterial and inhibition cicatrization from the root, can shorten the clotting time, accelerate wound Face healing and the formation for reducing scar.
The present invention protects the preparation method of above-mentioned aquagel simultaneously, includes the following steps：
S1. it dissolves chitosan in acetic acid solution, obtains chitosan acetic acid solution；Add graphene oxide into chitosan second It is mixed in acid solution, obtains chitosan/oxidized graphene mixed solution；
S2. Breviscapinun powder is added in chitosan/oxidized graphene mixed solution, after being uniformly mixed, deaeration, Obtain Breviscapinun/chitosan solution；
S3. be blended after additive being configured to corresponding additive aqueous solution, to be added dose of aqueous solution after mixing, by it It is blended with Breviscapinun/chitosan solution of S2, controlling additive aqueous solution with Breviscapinun/chitosan solution mass ratio is 2:1~4:1, then proceed to heating, stir to solution it is transparent after, stop heating, stirring, go bubble removing to get chitosan water-setting Glue.
Preferably, the mass fraction of chitosan is 2%~5% in chitosan acetic acid solution described in S1.
Preferably, the mass fraction of Breviscapinun is 1%~3% in Breviscapinun/chitosan solution described in S2.
Compared with prior art, the invention has the advantages that：
Hydrogel provided by the invention passes through effective combination of Breviscapinun, chitosan and graphene oxide, can accelerate wounds The healing of mouth has the characteristics that hemostasis, antibacterial and inhibition cicatrization from the root, can shorten the clotting time, the surface of a wound is accelerated to be cured Close and reduce the formation of scar.The hydrogel preparation method is simple and convenient, practical, and high molecular material used is nothing Poison, biodegradable material, manufactured composite hydrogel have good biocompatibility, biological degradability are good, absorbability is good, peace The advantages that Atoxic, has a good application prospect.
Specific embodiment
Further illustrate the present invention below in conjunction with specific embodiment, but embodiment the present invention is not done it is any type of It limits.Unless stated otherwise, the present invention uses reagent, method and apparatus is the art conventional reagents, method and apparatus.
Unless stated otherwise, following embodiment agents useful for same and material are commercially available.
The preparation of 1 aquagel of embodiment
（1）It is to be prepared by chitosan, graphene oxide, Breviscapinun, respectively the present embodiment provides a kind of aquagel Amounts of components is：Chitosan（10KDa）3g, graphene oxide（3KDa）0.5g, Breviscapinun 1.5g.
（2）Preparation method
According to above-mentioned quality, the raw material for standby of each component is chosen respectively, prepares the Breviscapinun/chitosan composite hydrogel, Specific method includes the following steps：
S1. it dissolves chitosan in acetic acid solution, obtains chitosan acetic acid solution；Add graphene oxide into chitosan second It is mixed in acid solution, obtains chitosan/oxidized graphene mixed solution；
S2. Breviscapinun powder is added in chitosan/oxidized graphene mixed solution, after being uniformly mixed, deaeration, Obtain Breviscapinun/chitosan solution；
S3. be blended after additive being configured to corresponding additive aqueous solution, to be added dose of aqueous solution after mixing, by it It is blended with Breviscapinun/chitosan solution of S2, controlling additive aqueous solution with Breviscapinun/chitosan solution mass ratio is 2:1~4:1, then proceed to heating, stir to solution it is transparent after, stop heating, stirring, go bubble removing to get chitosan water-setting Glue.
The preparation of 2 aquagel of embodiment
The present embodiment provides a kind of aquagels for inhibiting cicatrization, are by chitosan, graphene oxide, Breviscapinun It is prepared, dosage of each component is：Chitosan（20KDa）5g, graphene oxide（8KDa）0.8g, Breviscapinun 1.8g.
Specific preparation method reference implementation example 1, is no longer repeated herein.
The preparation of 3 aquagel of embodiment
The present embodiment provides a kind of aquagels for inhibiting cicatrization, are by chitosan, graphene oxide, Breviscapinun It is prepared, dosage of each component is：Chitosan（100KDa）4g, graphene oxide（5KDa）0.7g, Breviscapinun 1.6g.
Specific preparation method reference implementation example 1, is no longer repeated herein.
Hydrogel provided by the invention passes through effective combination of Breviscapinun, chitosan and graphene oxide, can accelerate to create The healing of face wound has the characteristics that hemostasis, antibacterial and inhibition cicatrization from the root, can shorten the clotting time, accelerate wound Face healing and the formation for reducing scar.The hydrogel preparation method is simple and convenient, practical, and high molecular material used is Nontoxic, biodegradable material, manufactured composite hydrogel have good biocompatibility, biological degradability are good, absorbability is good, The advantages that safe and non-toxic, has a good application prospect.
The above embodiment is a preferred embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment Limitation, other any changes, modifications, substitutions, combinations, simplifications made without departing from the spirit and principles of the present invention, It should be equivalent substitute mode, be included within the scope of the present invention.

Claims (7)

1. a kind of aquagel, which is characterized in that by mass ratio be 1~2:3~5:0.5~1 Breviscapinun, chitosan It is combined with graphene oxide.
2. aquagel according to claim 1, which is characterized in that the Breviscapinun, chitosan, graphene oxide Mass ratio be 1.5~1.8:3.5~4.5:0.6~0.8.
3. aquagel according to claim 1 or claim 2, which is characterized in that the molecular weight of the chitosan be 10KDa~ 100KDa, deacetylation are 90%~92%, and the molecular weight of the graphene oxide is 3000Da~8000Da.
4. a kind of prepare any one of claims 1 to 3 aquagel method, which is characterized in that include the following steps：
S1. it dissolves chitosan in acetic acid solution, obtains chitosan acetic acid solution；Add graphene oxide into chitosan second It is mixed in acid solution, obtains chitosan/oxidized graphene mixed solution；
S2. Breviscapinun powder is added in chitosan/oxidized graphene mixed solution, after being uniformly mixed, deaeration, Obtain Breviscapinun/chitosan solution；
S3. be blended after additive being configured to corresponding additive aqueous solution, to be added dose of aqueous solution after mixing, by it It is blended with Breviscapinun/chitosan solution of S2, controlling additive aqueous solution with Breviscapinun/chitosan solution mass ratio is 2:1~4:1, then proceed to heating, stir to solution it is transparent after, stop heating, stirring, go bubble removing to get chitosan water-setting Glue.
5. according to the method described in claim 4, it is characterized in that, the mass fraction of acetic acid solution described in S1 be 0.5%~2%, The mass fraction of chitosan is 2%~5% in chitosan acetic acid solution.
6. according to the method described in claim 4, it is characterized in that, Breviscapinun in Breviscapinun/chitosan solution described in S2 Mass fraction be 1%~3%.
7. any aquagel of claims 1 to 3 inhibits the application in cicatrization preparation in preparation.
CN201810557407.2A 2018-06-01 2018-06-01 A kind of aquagel and preparation method thereof Withdrawn CN108841013A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112587655A (en) * 2020-12-29 2021-04-02 山东爱维德生物科技有限公司 Aloe arborescens-chitosan-graphene oxide gel freeze-dried powder for burns

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112587655A (en) * 2020-12-29 2021-04-02 山东爱维德生物科技有限公司 Aloe arborescens-chitosan-graphene oxide gel freeze-dried powder for burns

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