CN108837173A - A kind of eccentric sexual oppression dressing and its production method being closed after treatment for vein - Google Patents

Abstract

The invention discloses an eccentric compressive dressing for venous closure treatment, which relates to the technical field of hemostatic materials, and the main point of the technical solution is to include hemostatic gauze, and the hemostatic gauze includes fabric, a hemostatic agent and a sterilizing agent impregnated in the fabric; The hemostatic agent is prepared from the following ingredients in parts by weight: 5-8 parts of huanglongwei, 8-10 parts of amaranth, 4-7 parts of rich cabbage, 5-9 parts of seabuckthorn oil, 3-3 parts of edetate sodium 6 parts, Panax notoginseng 2‑4 parts, Sedum notoginseng 1‑3 parts, Glauber's salt 2.5‑3.5 parts, Rhubarb 1.5‑2.5 parts, Sophora japonica 1‑3 parts, Agrimony 3‑4 parts, Artemisia argyi 3‑4 parts 1-3 parts of Puhuang; the bactericidal disinfectant is prepared from the following components by weight: 9-11 parts of cassia bark, 5-9 parts of Aoba dan, 3-8 parts of ginseng, 2-5 parts of Angelica dahurica . The invention solves the problems of long hemostasis time and easy infection of the wound, and achieves the effects of fast hemostasis and sterilization.

Description

A kind of eccentric compression dressing and its production method after vein closure treatment

technical field

The invention relates to the technical field of medical hemostatic materials, more specifically, it relates to an eccentric compressive dressing for vein closure treatment and a production method thereof.

Background technique

When treating varicose veins, it is necessary to puncture the bleeding port on the blood vessels of the varicose veins in the leg, then cover the bleeding port with hemostatic gauze, put on varicose vein socks, and fix the hemostatic gauze on the bleeding port to heal the bleeding port.

In the prior art, you can refer to the Chinese invention patent document with the authorized announcement number CN103800940B, which discloses a hemostatic dressing and its preparation method, including the following steps: weighing mineral hemostatic particles, softener, adhesive, and antibacterial material , procoagulant material and water; mineral hemostatic granules, softener, and adhesive are added to water and mixed, boiled, cooled, added antibacterial material and procoagulant material and mixed to obtain hemostatic agent suspension; the hemostatic agent The suspension is fixedly adhered to the support matrix and dried to obtain a hemostatic dressing.

The existing hemostatic dressing utilizes mineral hemostatic particles as part of the hemostatic material. The mineral particles are bonded to the support matrix under the action of the adhesive. When the mineral particles come into contact with the wound, it is easy to cause wound infection. Therefore, It is necessary to produce an eccentric compression dressing and a production method thereof that can quickly stop bleeding and can be sterilized for vein closure treatment.

Contents of the invention

Aiming at the deficiencies in the prior art, the object of the present invention is to provide an eccentric compression dressing for venous closure treatment, which can prepare rapid hemostasis and can Sterilized eccentric compression dressing for post-venous closure therapy.

In order to achieve the above object, the present invention provides the following technical solutions: an eccentric compression dressing for venous closure treatment, including hemostatic gauze, the hemostatic gauze includes fabric, hemostatic agent and sterilizing agent impregnated in the fabric; The mass ratio of the hemostatic agent to the bactericidal and disinfectant agent is 1.3-1.5:0.6-0.9; the hemostatic agent is prepared from the following ingredients in parts by weight: 5-8 parts of huanglongwei, 8-10 parts of amaranth, Fuguicai 4-7 parts, seabuckthorn oil 5-9 parts, edetate sodium 3-6 parts, Sanqi 2-4 parts, Sedum notoginseng 1-3 parts, Glauber's salt 2.5-3.5 parts, rhubarb 1.5-2.5 parts , 1-3 parts of Sophora japonica, 3-4 parts of Agrimony, 3-4 parts of Folium Artemisiae Argyi, 1-3 parts of Puhuang; the bactericidal disinfectant is prepared by the following components by weight: 9-11 parts of cassia bark, 5-9 parts of Qingye Dan, 3-8 parts of tail ginseng, and 2-5 parts of Angelica dahurica.

By adopting the above-mentioned technical scheme, Huanglongwei contains agrimonin, agrilide, catechol, etc., which can shorten blood coagulation time, increase platelets, promote platelet production and increase blood calcium, and have a better rapid hemostasis effect ;Amaranth can clear away heat and detoxify, cool blood and stop bleeding; the stems and leaves of Fuguicai contain a lot of nutrients such as alginate, mannitol, vitamin B, sulphur, potassium and various amino acids, which have a good hemostatic effect; The total flavonoids of seabuckthorn in seabuckthorn oil can reduce hyperlipidemia, soften blood vessels, and clear the deposits on the inner wall of blood vessels, so that the deposits at the bleeding port can be removed; Panax notoginseng and sedum notoginseng can shrink local blood vessels, and have a good hemostatic effect. Pain effect; using Glauber's salt and rhubarb together can clear away heat and detoxify, stop bleeding and astringe, reduce swelling and relieve pain, and make wounds heal quickly; Sophora japonica contains a variety of chemical components, among which rutin and its aglycone quercetin can maintain blood capillaries The normal resistance of blood vessels can reduce the permeability of blood vessels, increase the elasticity of capillaries, and achieve rapid hemostasis of blood vessels; Agrimony, Artemisia argyi and Puhuang all have rapid convergence and hemostasis, shorten blood coagulation time, increase platelet count, and inhibit fibrinolysis. Enzyme activity, good hemostatic effect; cinnamon can inhibit the growth of a variety of pathogenic fungi, and can sterilize; Qingye Dan has the effects of clearing away heat and detoxification, anti-inflammatory and sterilizing, can prevent inflammation of the bleeding port, and inhibit bacterial growth; ginseng and Angelica dahurica Antipyretic, analgesic, and fungal growth inhibition; using a variety of yellow keel, iron amaranth, rich vegetables, etc., which can shorten the blood clotting time, increase platelets, and quickly stop bleeding raw materials, which can quickly stop bleeding at the bleeding site and can restrain the bleeding site , to prevent re-bleeding; using cinnamon bark, Qingyedan, tail ginseng and Angelica dahurica can inhibit the growth of bacteria, prevent infection of the bleeding port, and promote rapid healing of the bleeding port.

The present invention is further configured as follows: the hemostatic gauze also includes a scar-removing agent, the mass ratio of the scar-removing agent to the hemostatic agent is 0.2-0.4:1.3-1.5, and the scar-removing agent is composed of the following components by weight: Prepared in 3 parts: 4-9 parts of aloe vera juice, 2-6 parts of fresh cactus juice, 1-4 parts of honey.

By adopting the above-mentioned technical scheme, aloe vera juice is rich in aloe-emodin and Antraguinong complex, which can promote the healing of the bleeding port and leave no scars at the bleeding port when applied on the bleeding port; cactus juice and honey can sterilize, disinfect, Reduce pain, promote wound healing, prevent infection, and prevent bleeding from scarring; adding scar remover to the hemostatic gauze can promote wound healing, promote muscle growth, and prevent bleeding from scarring.

The present invention is further configured as follows: the hemostatic gauze also includes an analgesic, the mass ratio of the analgesic to the hemostatic agent is 0.1-0.2:1.3-1.5, and the analgesic includes vitamin B12 6-10 3-6 parts of borneol, 4-7 parts of frankincense, 1-4 parts of sumac.

By adopting the above technical scheme, borneol can clear away heat and relieve pain, reduce swelling, antiseptic and promote muscle growth, and promote the convergence and healing of bleeding ports; frankincense can reduce swelling and muscle growth, relieve pain, and astringe wounds; Analgesic, which can relieve the patient's pain and promote wound healing.

The present invention is further set as follows: the hemostatic gauze also includes a healing agent, the mass ratio of the healing agent to the hemostatic agent is 0.3-0.5:1.3-1.5, and the healing agent is prepared from the following ingredients in parts by weight Composition: 4-8 parts of vitamin B2, 5-10 parts of vitamin B6, 4-9 parts of vitamin C.

By adopting the above technical scheme, vitamin B2 can reduce swelling, promote cell regeneration, and promote skin growth. It is shared with vitamin B6 and has a better effect. Vitamin B6 can protect vascular endothelial cells, and vitamin C can maintain immune function and keep blood vessels intact. Promotes healing of bleeding wounds.

The present invention is further configured to: further include a net cover wrapped outside the hemostatic gauze for preventing the hemostatic gauze from spreading.

By adopting the above-mentioned technical scheme, the hemostatic gauze is wrapped in the net cover, so that the hemostatic gauze can be applied more concentratedly on the bleeding port without spreading, so that the hemostatic gauze can quickly stop bleeding from the bleeding port.

The present invention is further provided that: the side of the mesh cover in contact with the hemostatic gauze is provided with an adhesive layer for adhering the mesh cover to the hemostatic gauze.

By adopting the above technical solution, the viscose layer arranged on the side of the net cover close to the hemostatic gauze can facilitate the net cover to tightly wrap the hemostatic gauze in the net cover, preventing the hemostatic gauze from being scattered during use.

The present invention is further set as follows: the adhesive layer is prepared from the following components in parts by mass: 4-6 parts of nettle root, 5-8 parts of Bletilla striata, 2-3 parts of dandelion, 3-4 parts of forsythia, Bo 1-3 parts.

By adopting the above technical scheme, dandelion and forsythia can clear away heat and detoxify, reduce inflammation and relieve pain; puffball has obvious hemostatic effect, and has inhibitory effect on pathogenic fungi; It can inhibit the growth of fungi; nettle root has analgesic effect, and both nettle root and bletilla striata have certain viscosity, which can adhere the net cover to the hemostatic gauze, prevent the net cover from separating from the hemostatic gauze, and affect the use of the hemostatic gauze .

The present invention is further provided that: the net cover is made of elastic material.

By adopting the above technical scheme, the net cover made of elastic material has a certain degree of elasticity, and can be loaded with different amounts of hemostatic gauze, and can be loaded with hemostatic gauze according to the size of the hemostatic opening, so as to avoid the waste of hemostatic gauze and save the cost of hemostatic gauze Dosage.

In view of the deficiencies in the prior art, another object of the present invention is to provide a production method for eccentric compressive dressings after venous closure therapy, and the eccentric compressive dressings processed by this production method are used for venous occlusive therapy. The dressing can quickly stop bleeding and sterilize.

To achieve the above object, the present invention provides the following technical solutions: comprising the following steps:

(1) The total weight is 3.5-4.7 times the total weight of 5-8 parts of Huanglongwei, 8-10 parts of Amaranth, 4-7 parts of Fuguicai, 5-9 parts of seabuckthorn oil and 3-6 parts of edetate sodium Add 5-8 parts of yellow dragon tail, 8-10 parts of iron amaranth, 4-7 parts of Fuguicai, 5-9 parts of seabuckthorn oil and 3-6 parts of sodium edetate to the boiling water in turn, fry Boil twice, each time for 1-2 hours, combine the decoction after decoction, and filter with a microporous membrane;

(2) Add 2-4 parts of Panax notoginseng, 1-3 parts of Sedum notoginseng, 2.5-3.5 parts of Glauber's salt, 1.5-2.5 parts of rhubarb, 1-3 parts of Sophora japonica, 3- 4 parts of agrimony, 3-4 parts of mugwort leaves, 1-3 parts of Puhuang, decoct once for 2-3 hours, filter with a microporous membrane, concentrate the filtrate into a liquid medicine with a relative density of 0.46, spare;

(3) Take 9-11 parts of cinnamon, 2-5 parts of Angelica dahurica, 3-8 parts of pure water with 4.6-5.8 times the total mass of ginseng, add 9-11 parts of cinnamon, 2-5 parts of ginseng to the boiling water Angelica dahurica, 3-8 parts of tail ginseng, and boiled, then add 5-9 parts of Qingyedan, decoct three times, each decocting for 2.5-3 hours, combine the decocted decoction, and filter with a microporous membrane, Concentrate the filtrate into a medicinal solution with a relative density of 0.43 for subsequent use;

(4) Take 4-9 portions of aloe vera juice, heat it to 80-110°C, and slowly add 2-6 portions of cactus juice to the aloe vera juice at a speed of 300-500 rpm, stir evenly and heat up to 120-130°C ℃, increase the rotation speed to 600-800 rpm, add 1-4 parts of honey to the mixture, stir evenly, and set aside;

(5) Take 3-6 parts of borneol, 4-7 parts of frankincense, 1-4 parts of sumac and 6-10 parts of vitamin B12 for ball milling, the ball-to-material ratio is 1.8:1, and the ball milling time is 20-60min.

(6) Take 4-8 parts of vitamin B2, 5-10 parts of vitamin B6 and 4-9 parts of vitamin C for ball milling and pulverization, the ball-to-material ratio is 1.6:1, and the ball milling time is 30-50min, and set aside;

(7) Heat the liquid obtained in step (2) to 100-120 ° C, and at a speed of 200-300 rpm, the liquid obtained in step (3) and step (4), and the liquid obtained in step (5) and step The mixed powder of gained in (6) is added in the liquid of step (2) gained successively, be down to normal temperature after being incubated 20-30min;

(8) placing the fabric in the mixed solution obtained in step (7) for 40-60 min at a bath ratio of 1:30-50, and then taking out the soaked fabric and dehydrating for 5-8 min;

(9) placing the dehydrated fabric in step (8) under ultraviolet light for disinfection, the disinfection time is 20-30min;

(10) Smear the viscose layer on the fabric, and put the mesh cover on the fabric to obtain an eccentric compressive dressing for venous closure treatment.

By adopting the above-mentioned technical scheme, decocting the yellow dragon tail, iron amaranth, rich cabbage, seabuckthorn oil and sodium edetate first, and decocting twice, the extracts in each raw material can be completely extracted; in the step Add notoginseng, etc. to the mixture in (1), and decoct again, so that the extracts of Huanglongwei and notoginseng can be fully mixed and extracted completely; Boiling cinnamon bark, angelica dahurica and ginseng in water can facilitate the extraction of cinnamon bark, angelica and ginseng; heating aloe juice can play a role in sterilization, and adding cactus juice under stirring can facilitate the extraction of aloe juice and cactus Mix the juice evenly, because the honey is relatively viscous, increasing the temperature can facilitate the softening of the honey, increase the speed, and facilitate the mixture of honey, aloe vera juice and cactus juice; because the borneol is volatile and easy to sublime; the frankincense is preheated It is easy to soften; vitamin B12 will be damaged by preheating to a certain extent, so ball milling is used to grind borneol, frankincense, etc.; vitamin B2 is stable when heated and vitamin B6 is not resistant to high temperatures, so ball milling is used Grinding; finally, mix the obtained spare raw materials evenly, dehydrate the fabric after soaking completely, and then sterilize with ultraviolet light, and finally cover the hemostatic gauze with a net cover to make a quick hemostatic and sterilizable tissue for venous closure treatment Eccentric compression dressings.

The present invention is further set as: the ultraviolet rays in the step (9) refer to C-wave ultraviolet rays, and the irradiation wavelength is 250-270nm.

By adopting the above-mentioned technical scheme, C-wave ultraviolet rays can cause the death of growth cells or regenerative cells to achieve the effect of sterilization and disinfection. Sterilization of fabrics at a wavelength of 250-270nm can achieve more thorough sterilization.

In summary, compared with the prior art, the present invention has the following beneficial effects:

(1) The present invention can prepare an eccentric compression dressing for rapid hemostasis and sterilization after venous closure treatment by placing the fabric in the hemostatic agent and sterilizing agent for immersion;

(2) The present invention can make the bleeding port leave no scar by adding the scar removing agent in the eccentric compressive dressing after the venous closure treatment;

(3) The present invention can alleviate the patient's pain by adding an analgesic to the eccentric compression dressing used for venous closure therapy;

(4) The present invention can promote the healing of the hemorrhage and shorten the healing time by adding a healing agent in the eccentric compression dressing used for venous closure treatment;

(5) The present invention covers the hemostatic gauze with a net cover on the hemostatic gauze, wraps the hemostatic gauze with the net cover, prevents the hemostatic gauze from spreading, and makes the hemostatic gauze more concentratedly pressed on the bleeding port.

Detailed ways

Embodiment 1: An eccentric compression dressing for venous closure treatment, comprising hemostatic gauze and a mesh cover wrapped in the hemostatic gauze to prevent the hemostatic gauze from spreading; the mesh cover is made of elastic material; the mesh cover and the hemostatic gauze A viscose layer for adhering the hemostatic gauze to the hemostatic gauze is arranged on the contacting side; the viscose layer is made of the following components in parts by mass: 4 parts of nettle root, 5 parts of bletilla striata, 2 parts of dandelion, 3 parts of dandelion 1 part forsythia and 1 part puffball.

Wherein the hemostatic gauze comprises fabric, the hemostatic agent impregnated on the fabric, bactericidal disinfectant, scar remover, analgesic and healing agent; wherein the mass ratio of hemostatic agent, bactericidal disinfectant, scar remover, analgesic and healing agent is 1.3:0.6:0.2:0.1:0.3;

The hemostatic agent is prepared from the following ingredients in parts by mass: 5 parts of huanglongwei, 8 parts of amaranth, 4 parts of rich cabbage, 5 parts of seabuckthorn oil, 3 parts of edetate sodium, 2 parts of Panax notoginseng; 1 part of sedum sedum Panax notoginseng; 2.5 parts of Glauber's salt; 1.5 parts of rhubarb, 1 part of Sophora japonica, 3 parts of Agrimony, 3 parts of Artemisia argyi and 1 part of Puhuang; the sterilizing agent is prepared from the following ingredients in parts by mass: 9 parts of cinnamon, 5 parts Qingye Dan, 3 parts of ginseng and 2 parts of Angelica dahurica; the scar remover is prepared from the following ingredients by mass parts: 4 parts of aloe vera juice, 2 parts of fresh cactus juice and 1 part of honey; the analgesic is made of the following ingredients by weight Prepared in parts by mass: 6 parts of vitamin B12, 3 parts of borneol, 4 parts of frankincense and 1 part of sumac; the healing agent is prepared in parts by mass of the following ingredients: 4 parts of vitamin B2, 5 parts of vitamin B6 and 4 parts of vitamin c.

The production method of the eccentric compression dressing for venous closure therapy comprises the following steps:

(1) Take pure water with a total weight of 5 parts of Huanglongwei, 8 parts of Amaranth, 4 parts of Fuguicai, 5 parts of seabuckthorn oil and 3 parts of edetate sodium 3.5 times the total weight and boil it, and add 5 parts to the boiling water in turn. 1 part of yellow dragon tail, 8 parts of iron amaranth, 4 parts of Fuguicai, 5 parts of seabuckthorn oil and 3 parts of edetate sodium, decoct twice, each decoction for 1 hour, combine the decoction after decoction, and use microporous Membrane filtration;

(2) Add 2 parts of Panax notoginseng, 1 part of Sedum notoginseng, 2.5 parts of Glauber's salt, 1.5 parts of rhubarb, 1 part of Sophora japonica, 3 parts of Agrimony, 3 parts of Artemisia argyi, 1 part of cattail in the filtrate obtained in step (1) yellow, decocted once, the decocting time is 2 hours, filtered with a microporous membrane, and the filtrate was concentrated into a medicinal liquid with a relative density of 0.46, and set aside;

(3) Take 9 parts of cinnamon, 2 parts of Angelica dahurica, and 3 parts of ginseng in pure water with a total mass of 4.6 times, add 9 parts of cinnamon, 2 parts of Angelica dahurica, and 3 parts of ginseng into the boiling water, and boil it, then add 5 parts of Qingye Dan were decocted three times, each time decocted for 2.5 hours, combined the decocted decoction, and filtered with a microporous membrane, and the filtrate was concentrated into a medicinal solution with a relative density of 0.43 for subsequent use;

(4) Take 4 parts of aloe vera juice, heat it to 80°C, slowly add 2 parts of cactus juice to the aloe vera juice at a speed of 300 rpm, stir evenly, heat up to 120°C, and increase the speed to 600 rpm , add 1 part of honey to the mixture, stir evenly, set aside;

(5) Take 3 parts of borneol, 4 parts of frankincense, 1 part of sumac and 6 parts of vitamin B12 for ball milling, the ball-to-material ratio is 1.8:1, the ball milling time is 20 minutes, and set aside;

(6) Take 4 parts of vitamin B2, 5 parts of vitamin B6 and 4 parts of vitamin C and carry out ball milling, the ball-to-material ratio is 1.6:1, the ball milling time is 30min, and set aside;

(7) Heat the liquid obtained in step (2) to 100 ° C, and at a speed of 200 rpm, the liquid obtained in step (3) and step (4), and the liquid obtained in step (5) and step (6) The mixed powder of gained is added in the liquid of step (2) gained successively, is down to normal temperature after the insulation 20min;

(8) placing the fabric in the mixed solution obtained in step (7) for 40 minutes at a bath ratio of 1:30, and soaking for 40 minutes, taking out the soaked fabric, and dehydrating for 5 minutes;

(9) Place the dehydrated fabric in step (8) under C-wave ultraviolet light for disinfection, the irradiation wavelength is 250nm, and the disinfection time is 20min;

(10) Smear the viscose layer on the fabric, and put the mesh cover on the fabric to obtain an eccentric compressive dressing for venous closure treatment.

Embodiment 2: An eccentric compression dressing for venous closure treatment, comprising hemostatic gauze and a mesh cover wrapped outside the hemostatic gauze to prevent the hemostatic gauze from spreading; the mesh cover is made of elastic material; the mesh cover and hemostatic A viscose layer for adhering the hemostatic gauze to the hemostatic gauze is arranged on the side where the gauze contacts; 3.5 parts forsythia and 2 parts puffball.

Wherein the hemostatic gauze comprises fabric, the hemostatic agent impregnated on the fabric, bactericidal disinfectant, scar remover, analgesic and healing agent; wherein the mass ratio of hemostatic agent, bactericidal disinfectant, scar remover, analgesic and healing agent is 1.4:0.75:0.3:0.15:0.4;

The hemostatic agent is prepared from the following ingredients in parts by mass: 6.5 parts of huanglongwei, 9 parts of iron amaranth, 5.5 parts of rich cabbage, 7 parts of seabuckthorn oil, 4.5 parts of sodium edetate, 3 parts of Panax notoginseng, 2 parts of sedum sedum Panax notoginseng, 3 parts of Glauber's salt, 2 parts of rhubarb, 2 parts of Sophora japonica, 3.5 parts of Agrimony, 3.5 parts of Artemisia argyi and 2 parts of Puhuang; the sterilizing and disinfecting agent is prepared from the following ingredients by mass: 10 parts of cinnamon, 7 parts Qingye Dan, 5.5 parts of ginseng and 3.5 parts of Angelica dahurica; the scar remover is prepared from the following components by mass parts: 6.5 parts of aloe vera juice, 4 parts of fresh cactus juice and 2.5 parts of honey; the analgesic is made of the following components by weight Prepared in parts by mass: 8 parts of vitamin B12, 4.5 parts of borneol, 5.5 parts of frankincense and 2.5 parts of sumac; the healing agent is prepared by parts by mass of the following ingredients: 6 parts of vitamin B2, 7.5 parts of vitamin B6 and 6.5 parts of vitamin c.

The production method of the eccentric compression dressing for venous closure therapy comprises the following steps:

(1) Take 6.5 parts of Huanglongwei, 9 parts of Amaranth, 5.5 parts of Fuguicai, 7 parts of seabuckthorn oil and 4.5 parts of pure water 4.1 times the total weight of sodium edetate and boil it, and add 6.5 parts to the boiling water in turn. 5 parts of Huanglongwei, 9 parts of iron amaranth, 5.5 parts of Fuguicai, 7 parts of seabuckthorn oil and 4.5 parts of edetate sodium, decocted twice, each time for 1.5 hours, combined the decocted decoction, and used Microporous membrane filtration;

(2) Add 3 parts of Panax notoginseng, 2 parts of Sedum notoginseng, 3 parts of Glauber's salt, 2 parts of rhubarb, 2 parts of Sophora japonica, 3.5 parts of Agrimony, 3.5 parts of Artemisia argyi and 2 parts of cattail in the filtrate obtained in step (1) Yellow, decocted once, the decoction time is 2.5 hours, filtered with a microporous membrane, and the filtrate is concentrated into a medicinal liquid with a relative density of 0.46, and set aside;

(3) Take the pure water whose total mass is 10 parts of cinnamon, 3.5 parts of Angelica dahurica and 5.5 parts of tail ginseng 5.2 times the total mass, add 10 parts of cinnamon, 3.5 parts of Angelica dahurica and 5.5 parts of tail ginseng to the boiling water, and boil it, then add 7 parts of Qingye Dan were decocted three times, each decocting for 2.7 hours, the decoction after merging was decocted, and filtered with a microporous membrane, and the filtrate was concentrated into a medicinal solution with a relative density of 0.43 for subsequent use;

(4) Take 6.5 parts of aloe vera juice, heat it to 95°C, slowly add 4 parts of cactus juice to the aloe vera juice at a speed of 400 rpm, stir evenly, heat up to 125°C, and increase the speed to 700 rpm , add 2.5 parts of honey to the mixture, stir evenly, set aside;

(5) Take 4.5 parts of borneol, 5.5 parts of frankincense, 2.5 parts of hematoxylin and 8 parts of vitamin B12 for ball milling and pulverization, the ball-to-material ratio is 1.8:1, and the ball milling time is 40 minutes, and set aside;

(6) Take 6 parts of vitamin B2, 7.5 parts of vitamin B6 and 6.5 parts of vitamin C and carry out ball milling, the ball-to-material ratio is 1.6:1, and the ball milling time is 40min, and set aside;

(7) Heat the liquid obtained in step (2) to 110 ° C, and at a speed of 250 rpm, the liquid obtained in step (3) and step (4), and the liquid obtained in step (5) and step (6) The mixed powder of gained is added in the liquid of step (2) gained successively, is down to normal temperature after the insulation 25min;

(8) placing the fabric in the mixed solution obtained in step (7) for 50 minutes at a bath ratio of 1:40, and soaking for 50 minutes, taking out the fabric after soaking, and dehydrating for 6.5 minutes;

(9) Place the dehydrated fabric in step (8) under C-wave ultraviolet light for disinfection, the irradiation wavelength is 260nm, and the disinfection time is 25min;

(10) Smear the viscose layer on the fabric, and put the mesh cover on the fabric to obtain an eccentric compressive dressing for venous closure treatment.

Embodiment 3: An eccentric compression dressing for venous closure treatment, comprising hemostatic gauze and a mesh cover wrapped in the hemostatic gauze to prevent the hemostatic gauze from spreading; the mesh cover is made of elastic material; the mesh cover and the hemostatic gauze A viscose layer for adhering the hemostatic gauze to the hemostatic gauze is arranged on the contacting side; the viscose layer is made of the following components in parts by mass: 6 parts of nettle root, 8 parts of bletilla striata, 3 parts of dandelion, 4 parts by mass. 1 part forsythia and 3 parts puffball.

Wherein the hemostatic gauze comprises fabric, the hemostatic agent impregnated on the fabric, bactericidal disinfectant, scar remover, analgesic and healing agent; wherein the mass ratio of hemostatic agent, bactericidal disinfectant, scar remover, analgesic and healing agent is 1.53:0.9:0.4:0.2:0.5;

The hemostatic agent is prepared from the following ingredients in parts by mass: 8 parts of huanglongwei, 10 parts of iron amaranth, 7 parts of rich cabbage, 9 parts of seabuckthorn oil, 6 parts of sodium edetate, 4 parts of Panax notoginseng, and 3 parts of sedum sedum Panax notoginseng, 3.5 parts of Glauber's salt, 2.5 parts of rhubarb, 3 parts of Sophora japonica, 4 parts of agrimony, 4 parts of mugwort leaves, and 3 parts of cattail; the sterilizing agent is prepared from the following ingredients by mass: 11 parts of cinnamon, 9 parts Qingye Dan, 8 parts of tail ginseng and 5 parts of Angelica dahurica; the scar remover is prepared from the following ingredients in parts by mass: 9 parts of aloe vera juice, 6 parts of fresh cactus juice and 4 parts of honey; the analgesic is made of the following ingredients in parts by mass Prepared by parts by mass: 10 parts of vitamin B12, 6 parts of borneol, 7 parts of frankincense and 4 parts of sumac; the healing agent is prepared by parts by mass of the following ingredients: 8 parts of vitamin B2, 10 parts of vitamin B6 and 9 parts of c.

The production method of the eccentric compression dressing for venous closure therapy comprises the following steps:

(1) Take 8 parts of Huanglongwei, 10 parts of Amaranth, 7 parts of Fuguicai, 9 parts of seabuckthorn oil and 6 parts of pure water 4.7 times the total weight of sodium edetate and boil it, and add 8 parts to the boiling water in turn. 1 part of Huanglongwei, 10 parts of iron amaranth, 7 parts of Fuguicai, 9 parts of seabuckthorn oil and 6 parts of edetate sodium, decocted twice, each time for 2 hours, combined the decoction after decoction, and used microporous Membrane filtration;

(2) Add 4 parts of notoginseng, 3 parts of sedum notoginseng, 3.5 parts of mirabilite, 2.5 parts of rhubarb, 3 parts of Sophora japonica, 4 parts of Agrimony, 4 parts of Artemisia argyi, 3 parts of cattail in the filtrate obtained in step (1) yellow, decocted once for 3 hours, filtered through a microporous membrane, and concentrated the filtrate into a medicinal liquid with a relative density of 0.46 for subsequent use;

(3) Take 11 parts of cassia bark, 5 parts of Angelica dahurica, and 8 parts of ginseng in pure water with a total mass of 5.8 times the total mass, add 11 parts of cinnamon bark, 5 parts of Angelica dahurica, and 8 parts of ginseng to the boiling water, and boil it, then add 9 parts of Qingye Dan were decocted three times, each time decocted for 3 hours, combined the decocted decoction, and filtered with a microporous membrane, and the filtrate was concentrated into a medicinal solution with a relative density of 0.43 for subsequent use;

(4) Take 9 parts of aloe vera juice, heat it to 110°C, slowly add 6 parts of cactus juice to the aloe vera juice at a speed of 500 rpm, stir evenly, heat up to 130°C, and increase the speed of rotation to 800 rpm , add 4 parts of honey to the mixture, stir evenly, and set aside;

(5) Take 6 parts of borneol, 7 parts of frankincense, 4 parts of sumac and 10 parts of vitamin B12 and carry out ball milling, the ball-to-material ratio is 1.8:1, and the ball milling time is 60 minutes, and set aside;

(6) Take 8 parts of vitamin B2, 10 parts of vitamin B6 and 9 parts of vitamin C and carry out ball milling, the ball-to-material ratio is 1.6:1, and the ball milling time is 50 minutes, and set aside;

(7) Heat the liquid obtained in step (2) to 120 ° C, and at a speed of 300 rpm, the liquid obtained in step (3) and step (4), and the liquid obtained in step (5) and step (6) The mixed powder of gained is added in the liquid of step (2) gained successively, is down to normal temperature after the insulation 30min;

(8) placing the fabric in the mixed solution obtained in step (7) for 60 minutes at a bath ratio of 1:50, and soaking for 60 minutes, taking out the fabric after soaking, and dehydrating for 8 minutes;

(9) Place the dehydrated fabric in step (8) under C-wave ultraviolet light for disinfection, the irradiation wavelength is 270nm, and the disinfection time is 30min;

(10) Smear the viscose layer on the fabric, and put the mesh cover on the fabric to obtain an eccentric compressive dressing for venous closure treatment.

Comparative example 1: An eccentric compression dressing for venous closure treatment, including hemostatic gauze and a mesh cover wrapped outside the hemostatic gauze to prevent the hemostatic gauze from spreading; the mesh cover is made of elastic material; the mesh cover and the hemostatic gauze A viscose layer for adhering the hemostatic gauze to the hemostatic gauze is arranged on the contacting side; the viscose layer is made of the following components in parts by mass: 5 parts of nettle root, 6.5 parts of bletilla striata, 2.5 parts of dandelion, 3.5 parts of 1 part forsythia and 2 parts puffball.

Wherein the hemostatic gauze comprises fabric, bactericidal disinfectant impregnated on the fabric, scar remover, analgesic and healing agent; wherein the mass ratio of bactericidal disinfectant, scar remover, analgesic and healer is 0.75:0.3:0.15 :0.4;

The sterilizing and disinfecting agent is prepared by parts by mass of the following ingredients: 10 parts of cassia bark, 7 parts of Qingyedan, 5.5 parts of ginseng and 3.5 parts of Angelica dahurica; the scar remover is prepared by parts by mass of the following ingredients: 6.5 parts of aloe vera Juice, 4 parts of fresh cactus juice and 2.5 parts of honey; the analgesic is prepared from the following ingredients in parts by mass: 8 parts of vitamin B12, 4.5 parts of borneol, 5.5 parts of frankincense and 2.5 parts of sumac; the healing agent is made of the following ingredients Prepared by parts by mass: 6 parts of vitamin B2, 7.5 parts of vitamin B6 and 6.5 parts of vitamin C.

The production method of the eccentric compression dressing for venous closure therapy comprises the following steps:

(1) Take 3 parts of Panax notoginseng, 2 parts of Sedum Sanqi, 3 parts of Glauber's salt, 2 parts of rhubarb, 2 parts of Sophora japonica, 3.5 parts of Agrimony, 3.5 parts of Artemisia argyi and 2 parts of Puhuang, decoct once, decocting time For 2.5 hours, filter with a microporous membrane, concentrate the filtrate into a medicinal solution with a relative density of 0.46, and set aside;

(2) Take 10 parts of cassia bark, 3.5 parts of Angelica dahurica and 5.5 parts of ginseng in pure water with a total mass of 5.2 times, add 10 parts of cinnamon, 3.5 parts of Angelica dahurica and 5.5 parts of ginseng into the boiling water, and boil, then add 7 parts of Qingye Dan were decocted three times, each decocting for 2.7 hours, the decoction after merging was decocted, and filtered with a microporous membrane, and the filtrate was concentrated into a medicinal solution with a relative density of 0.43 for subsequent use;

(3) Take 6.5 parts of aloe vera juice, heat it to 95°C, slowly add 4 parts of cactus juice to the aloe vera juice at a speed of 400 rpm, stir evenly, heat up to 125°C, and increase the speed to 700 rpm , add 2.5 parts of honey to the mixture, stir evenly, set aside;

(4) Take 4.5 parts of borneol, 5.5 parts of frankincense, 2.5 parts of hematoxylin and 8 parts of vitamin B12 and carry out ball milling, the ball-to-material ratio is 1.8:1, the ball milling time is 40min, and set aside;

(5) Take 6 parts of vitamin B2, 7.5 parts of vitamin B6 and 6.5 parts of vitamin C and carry out ball milling, the ball-to-material ratio is 1.6:1, and the ball milling time is 40 minutes, and set aside;

(6) Heat the liquid obtained in step (1) to 110 ° C, and at a speed of 250 rpm, the liquid obtained in step (2) and step (3), and the liquid obtained in step (4) and step (5) The mixed powder of gained is added in the liquid of step (1) gained successively, is down to normal temperature after the insulation 25min;

(7) placing the fabric in the mixed solution obtained in step (6) for 50 minutes at a bath ratio of 1:40, and soaking for 50 minutes, taking out the fabric after soaking, and dehydrating for 6.5 minutes;

(8) Place the dehydrated fabric in step (7) under C-wave ultraviolet light for disinfection, the irradiation wavelength is 260nm, and the disinfection time is 25min;

(9) Smear the viscose layer on the fabric, and cover the mesh cover on the fabric to obtain an eccentric compressive dressing for venous closure treatment.

Comparative example 2: An eccentric compression dressing for venous closure treatment, including hemostatic gauze and a mesh cover wrapped outside the hemostatic gauze to prevent the hemostatic gauze from spreading; the mesh cover is made of elastic material; the mesh cover and the hemostatic gauze A viscose layer for adhering the hemostatic gauze to the hemostatic gauze is arranged on the contacting side; the viscose layer is made of the following components in parts by mass: 5 parts of nettle root, 6.5 parts of bletilla striata, 2.5 parts of dandelion, 3.5 parts of 1 part forsythia and 2 parts puffball.

Wherein the hemostatic gauze comprises fabric, hemostatic agent, scar remover, analgesic and healing agent impregnated on the fabric; wherein the mass ratio of hemostatic agent, scar remover, analgesic and healer is 1.4:0.3:0.15:0.4 ;

The hemostatic agent is prepared from the following ingredients in parts by mass: 6.5 parts of huanglongwei, 9 parts of iron amaranth, 5.5 parts of rich cabbage, 7 parts of seabuckthorn oil, 4.5 parts of sodium edetate, 3 parts of Panax notoginseng, 2 parts of sedum sedum Panax notoginseng, 3 parts of mirabilite, 2 parts of rhubarb, 2 parts of Sophora japonica, 3.5 parts of agrimony, 3.5 parts of mugwort leaves and 2 parts of cattail; part of fresh cactus juice and 2.5 parts of honey; the analgesic is prepared from the following components by mass parts: 8 parts of vitamin B12, 4.5 parts of borneol, 5.5 parts of frankincense and 2.5 parts of sumac; the healing agent is made of the following components by mass parts Prepared with: 6 parts vitamin B2, 7.5 parts vitamin B6 and 6.5 parts vitamin C.

The production method of the eccentric compression dressing for venous closure therapy comprises the following steps:

(1) Take 6.5 parts of Huanglongwei, 9 parts of Amaranth, 5.5 parts of Fuguicai, 7 parts of seabuckthorn oil and 4.5 parts of pure water 4.1 times the total weight of sodium edetate and boil it, and add 6.5 parts to the boiling water in turn. 5 parts of Huanglongwei, 9 parts of iron amaranth, 5.5 parts of Fuguicai, 7 parts of seabuckthorn oil and 4.5 parts of edetate sodium, decocted twice, each time for 1.5 hours, combined the decocted decoction, and used Microporous membrane filtration;

(2) Add 3 parts of Panax notoginseng, 2 parts of Sedum notoginseng, 3 parts of Glauber's salt, 2 parts of rhubarb, 2 parts of Sophora japonica, 3.5 parts of Agrimony, 3.5 parts of Artemisia argyi and 2 parts of cattail in the filtrate obtained in step (1) Yellow, decocted once, the decoction time is 2.5 hours, filtered with a microporous membrane, and the filtrate is concentrated into a medicinal liquid with a relative density of 0.46, and set aside;

(3) Take 6.5 parts of aloe vera juice, heat it to 95°C, slowly add 4 parts of cactus juice to the aloe vera juice at a speed of 400 rpm, stir evenly, heat up to 125°C, and increase the speed to 700 rpm , add 2.5 parts of honey to the mixture, stir evenly, set aside;

(4) Take 4.5 parts of borneol, 5.5 parts of frankincense, 2.5 parts of hematoxylin and 8 parts of vitamin B12 and carry out ball milling, the ball-to-material ratio is 1.8:1, the ball milling time is 40min, and set aside;

(5) Take 6 parts of vitamin B2, 7.5 parts of vitamin B6 and 6.5 parts of vitamin C and carry out ball milling, the ball-to-material ratio is 1.6:1, and the ball milling time is 40 minutes, and set aside;

(6) Heat the liquid obtained in step (2) to 110 ° C, and at a speed of 250 rpm, the liquid obtained in step (3) and the mixed powder obtained in step (4) and step (5) are sequentially Add in the liquid of step (2) gained, be down to normal temperature after the insulation 25min;

(7) placing the fabric in the mixed solution obtained in step (6) for 50 minutes at a bath ratio of 1:40, and soaking for 50 minutes, taking out the fabric after soaking, and dehydrating for 6.5 minutes;

(8) Place the dehydrated fabric in step (7) under C-wave ultraviolet light for disinfection, the irradiation wavelength is 260nm, and the disinfection time is 25min;

(9) Smear the viscose layer on the fabric, and cover the mesh cover on the fabric to obtain an eccentric compressive dressing for venous closure treatment.

Comparative example 3: An eccentric compression dressing for venous closure treatment, including hemostatic gauze and a mesh cover wrapped outside the hemostatic gauze to prevent the hemostatic gauze from spreading; the mesh cover is made of elastic material; the mesh cover and the hemostatic gauze A viscose layer for adhering the hemostatic gauze to the hemostatic gauze is arranged on the contacting side; the viscose layer is made of the following components in parts by mass: 5 parts of nettle root, 6.5 parts of bletilla striata, 2.5 parts of dandelion, 3.5 parts of 1 part forsythia and 2 parts puffball.

Wherein the hemostatic gauze comprises fabric, hemostatic agent, bactericidal disinfectant, analgesic and healing agent impregnated on the fabric; wherein the mass ratio of hemostatic agent, bactericidal disinfectant, analgesic and healing agent is 1.4:0.75:0.15:0.4 ;

The hemostatic agent is prepared from the following ingredients in parts by mass: 6.5 parts of huanglongwei, 9 parts of iron amaranth, 5.5 parts of rich cabbage, 7 parts of seabuckthorn oil, 4.5 parts of sodium edetate, 3 parts of Panax notoginseng, 2 parts of sedum sedum Panax notoginseng, 3 parts of Glauber's salt, 2 parts of rhubarb, 2 parts of Sophora japonica, 3.5 parts of Agrimony, 3.5 parts of Artemisia argyi and 2 parts of Puhuang; the sterilizing and disinfecting agent is prepared from the following ingredients by mass: 10 parts of cinnamon, 7 parts Qingye Dan, 5.5 parts of ginseng and 3.5 parts of Angelica dahurica; the analgesic is prepared from the following ingredients in parts by mass: 8 parts of vitamin B12, 4.5 parts of borneol, 5.5 parts of frankincense and 2.5 parts of sumac; the healing agent is made of the following The ingredients are prepared in parts by mass: 6 parts of vitamin B2, 7.5 parts of vitamin B6 and 6.5 parts of vitamin C.

The production method of the eccentric compression dressing for venous closure therapy comprises the following steps:

(1) Take 6.5 parts of Huanglongwei, 9 parts of Amaranth, 5.5 parts of Fuguicai, 7 parts of seabuckthorn oil and 4.5 parts of pure water 4.1 times the total weight of sodium edetate and boil it, and add 6.5 parts to the boiling water in turn. 5 parts of Huanglongwei, 9 parts of iron amaranth, 5.5 parts of Fuguicai, 7 parts of seabuckthorn oil and 4.5 parts of edetate sodium, decocted twice, each time for 1.5 hours, combined the decocted decoction, and used Microporous membrane filtration;

(2) Add 3 parts of Panax notoginseng, 2 parts of Sedum notoginseng, 3 parts of Glauber's salt, 2 parts of rhubarb, 2 parts of Sophora japonica, 3.5 parts of Agrimony, 3.5 parts of Artemisia argyi and 2 parts of cattail in the filtrate obtained in step (1) Yellow, decocted once, the decoction time is 2.5 hours, filtered with a microporous membrane, the filtrate is concentrated into a medicinal liquid with a relative density of 0.46, and set aside;

(3) Take the pure water whose total mass is 10 parts of cinnamon, 3.5 parts of Angelica dahurica and 5.5 parts of tail ginseng 5.2 times the total mass, add 10 parts of cinnamon, 3.5 parts of Angelica dahurica and 5.5 parts of tail ginseng to the boiling water, and boil it, then add 7 parts of Qingye Dan were decocted three times, each decocting for 2.7 hours, the decoction after merging was decocted, and filtered with a microporous membrane, and the filtrate was concentrated into a medicinal solution with a relative density of 0.43 for subsequent use;

(4) Take 4.5 parts of borneol, 5.5 parts of frankincense, 2.5 parts of hematoxylin and 8 parts of vitamin B12 and carry out ball milling, the ball-to-material ratio is 1.8:1, and the ball milling time is 40 minutes, and set aside;

(5) Take 6 parts of vitamin B2, 7.5 parts of vitamin B6 and 6.5 parts of vitamin C and carry out ball milling, the ball-to-material ratio is 1.6:1, the ball milling time is 40min, and set aside;

(6) Heat the liquid obtained in step (2) to 110 ° C, and at a speed of 250 rpm, the liquid obtained in step (3) and the mixed powder obtained in step (4) and step (5) are sequentially Add in the liquid of step (2) gained, be down to normal temperature after the insulation 25min;

(7) placing the fabric in the mixed solution obtained in step (6) for 50 minutes at a bath ratio of 1:40, and soaking for 50 minutes, taking out the fabric after soaking, and dehydrating for 6.5 minutes;

(8) Place the dehydrated fabric in step (7) under C-wave ultraviolet light for disinfection, the irradiation wavelength is 260nm, and the disinfection time is 25min;

(9) Smear the viscose layer on the fabric, and cover the mesh cover on the fabric to obtain an eccentric compressive dressing for venous closure treatment.

Comparative example 4: An eccentric compression dressing for venous closure treatment, including hemostatic gauze and a mesh cover wrapped outside the hemostatic gauze to prevent the hemostatic gauze from spreading; the mesh cover is made of elastic material; the mesh cover and the hemostatic gauze A viscose layer for adhering the hemostatic gauze to the hemostatic gauze is arranged on the contacting side; the viscose layer is made of the following components in parts by mass: 5 parts of nettle root, 6.5 parts of bletilla striata, 2.5 parts of dandelion, 3.5 parts of 1 part forsythia and 2 parts puffball.

Wherein the hemostatic gauze comprises fabric, the hemostatic agent impregnated on the fabric, sterilizing and disinfecting agent, scar removing agent, analgesic and healing agent; wherein the mass ratio of hemostatic agent, sterilizing and disinfecting agent, scar removing agent and healing agent is 1.4:0.75 :0.3:0.4;

The hemostatic agent is prepared from the following ingredients in parts by mass: 6.5 parts of huanglongwei, 9 parts of iron amaranth, 5.5 parts of rich cabbage, 7 parts of seabuckthorn oil, 4.5 parts of sodium edetate, 3 parts of Panax notoginseng, 2 parts of sedum sedum Panax notoginseng, 3 parts of Glauber's salt, 2 parts of rhubarb, 2 parts of Sophora japonica, 3.5 parts of Agrimony, 3.5 parts of Artemisia argyi and 2 parts of Puhuang; the sterilizing and disinfecting agent is prepared from the following ingredients by mass: 10 parts of cinnamon, 7 parts Qingye Dan, 5.5 parts of ginseng and 3.5 parts of Angelica dahurica; the scar remover is prepared from the following ingredients by mass parts: 6.5 parts of aloe vera juice, 4 parts of fresh cactus juice and 2.5 parts of honey; the healing agent is made of the following ingredients by mass prepared from: 6 parts vitamin B2, 7.5 parts vitamin B6 and 6.5 parts vitamin C.

The production method of the eccentric compression dressing for venous closure therapy comprises the following steps:

(1) Take 6.5 parts of Huanglongwei, 9 parts of Amaranth, 5.5 parts of Fuguicai, 7 parts of seabuckthorn oil and 4.5 parts of pure water 4.1 times the total weight of sodium edetate and boil it, and add 6.5 parts to the boiling water in turn. 5 parts of Huanglongwei, 9 parts of iron amaranth, 5.5 parts of Fuguicai, 7 parts of seabuckthorn oil and 4.5 parts of edetate sodium, decocted twice, each time for 1.5 hours, combined the decocted decoction, and used Microporous membrane filtration;

(2) Add 3 parts of Panax notoginseng, 2 parts of Sedum notoginseng, 3 parts of Glauber's salt, 2 parts of rhubarb, 2 parts of Sophora japonica, 3.5 parts of Agrimony, 3.5 parts of Artemisia argyi and 2 parts of cattail in the filtrate obtained in step (1) Yellow, decocted once, the decoction time is 2.5 hours, filtered with a microporous membrane, and the filtrate is concentrated into a medicinal liquid with a relative density of 0.46, and set aside;

(3) Take the pure water whose total mass is 10 parts of cinnamon, 3.5 parts of Angelica dahurica and 5.5 parts of tail ginseng 5.2 times the total mass, add 10 parts of cinnamon, 3.5 parts of Angelica dahurica and 5.5 parts of tail ginseng to the boiling water, and boil it, then add 7 parts of Qingye Dan were decocted three times, each decocting for 2.7 hours, the decoction after merging was decocted, and filtered with a microporous membrane, and the filtrate was concentrated into a medicinal solution with a relative density of 0.43 for subsequent use;

(4) Take 6.5 parts of aloe vera juice, heat it to 95°C, slowly add 4 parts of cactus juice to the aloe vera juice at a speed of 400 rpm, stir evenly, heat up to 125°C, and increase the speed to 700 rpm , add 2.5 parts of honey to the mixture, stir evenly, set aside;

(5) Take 6 parts of vitamin B2, 7.5 parts of vitamin B6 and 6.5 parts of vitamin C and carry out ball milling, the ball-to-material ratio is 1.6:1, and the ball milling time is 40 minutes, and set aside;

(6) Heat the liquid obtained in step (2) to 110 ° C, and at a speed of 250 rpm, the liquid obtained in step (3) and step (4) and the mixed powder obtained in step (5) are sequentially Add in the liquid of step (2) gained, be down to normal temperature after the insulation 25min;

(7) placing the fabric in the mixed solution obtained in step (6) for 50 minutes at a bath ratio of 1:40, and soaking for 50 minutes, taking out the fabric after soaking, and dehydrating for 6.5 minutes;

(8) Place the dehydrated fabric in step (7) under C-wave ultraviolet light for disinfection, the irradiation wavelength is 260nm, and the disinfection time is 25min;

(9) Smear the viscose layer on the fabric, and cover the mesh cover on the fabric to obtain an eccentric compressive dressing for venous closure treatment.

Comparative example 5: An eccentric compression dressing for venous closure treatment, including hemostatic gauze and a mesh cover wrapped outside the hemostatic gauze to prevent the hemostatic gauze from spreading; the mesh cover is made of elastic material; the mesh cover and the hemostatic gauze A viscose layer for adhering the hemostatic gauze to the hemostatic gauze is arranged on the contacting side; the viscose layer is made of the following components in parts by mass: 5 parts of nettle root, 6.5 parts of bletilla striata, 2.5 parts of dandelion, 3.5 parts of 1 part forsythia and 2 parts puffball.

Wherein the hemostatic gauze comprises fabric, the hemostatic agent impregnated on the fabric, bactericidal disinfectant, scar remover, analgesic and healing agent; wherein the mass ratio of hemostatic agent, bactericidal disinfectant, scar remover, analgesic is 1.4: 0.75:0.3:0.15;

The hemostatic agent is prepared from the following ingredients in parts by mass: 6.5 parts of huanglongwei, 9 parts of iron amaranth, 5.5 parts of rich cabbage, 7 parts of seabuckthorn oil, 4.5 parts of sodium edetate, 3 parts of Panax notoginseng, 2 parts of sedum sedum Panax notoginseng, 3 parts of Glauber's salt, 2 parts of rhubarb, 2 parts of Sophora japonica, 3.5 parts of Agrimony, 3.5 parts of Artemisia argyi and 2 parts of Puhuang; the sterilizing and disinfecting agent is prepared from the following ingredients by mass: 10 parts of cinnamon, 7 parts Qingye Dan, 5.5 parts of ginseng and 3.5 parts of Angelica dahurica; the scar remover is prepared from the following components by mass parts: 6.5 parts of aloe vera juice, 4 parts of fresh cactus juice and 2.5 parts of honey; the analgesic is made of the following components by weight Prepared in parts by mass: 8 parts of vitamin B12, 4.5 parts of borneol, 5.5 parts of frankincense and 2.5 parts of sumac.

The production method of the eccentric compression dressing for venous closure therapy comprises the following steps:

(1) Take 6.5 parts of Huanglongwei, 9 parts of Amaranth, 5.5 parts of Fuguicai, 7 parts of seabuckthorn oil and 4.5 parts of pure water 4.1 times the total weight of sodium edetate and boil it, and add 6.5 parts to the boiling water in turn. 5 parts of Huanglongwei, 9 parts of iron amaranth, 5.5 parts of Fuguicai, 7 parts of seabuckthorn oil and 4.5 parts of edetate sodium, decocted twice, each time for 1.5 hours, combined the decocted decoction, and used Microporous membrane filtration;

(2) Add 3 parts of Panax notoginseng, 2 parts of Sedum notoginseng, 3 parts of Glauber's salt, 2 parts of rhubarb, 2 parts of Sophora japonica, 3.5 parts of Agrimony, 3.5 parts of Artemisia argyi and 2 parts of cattail in the filtrate obtained in step (1) Yellow, decocted once, the decoction time is 2.5 hours, filtered with a microporous membrane, and the filtrate is concentrated into a medicinal liquid with a relative density of 0.46, and set aside;

(3) Take the pure water whose total mass is 10 parts of cinnamon, 3.5 parts of Angelica dahurica and 5.5 parts of tail ginseng 5.2 times the total mass, add 10 parts of cinnamon, 3.5 parts of Angelica dahurica and 5.5 parts of tail ginseng to the boiling water, and boil it, then add 7 parts of Qingye Dan were decocted three times, each decocting for 2.7 hours, the decoction after merging was decocted, and filtered with a microporous membrane, and the filtrate was concentrated into a medicinal solution with a relative density of 0.43 for subsequent use;

(4) Take 6.5 parts of aloe vera juice, heat it to 95°C, slowly add 4 parts of cactus juice to the aloe vera juice at a speed of 400 rpm, stir evenly, heat up to 125°C, and increase the speed to 700 rpm , add 2.5 parts of honey to the mixture, stir evenly, set aside;

(5) Take 4.5 parts of borneol, 5.5 parts of frankincense, 2.5 parts of hematoxylin and 8 parts of vitamin B12 for ball milling and pulverization, the ball-to-material ratio is 1.8:1, and the ball milling time is 40 minutes, and set aside;

(6) Heat the liquid obtained in step (2) to 110 ° C, and at a speed of 250 rpm, the liquid obtained in step (3) and step (4) and the mixed powder obtained in step (5) are sequentially Add in the liquid of step (2) gained, be down to normal temperature after the insulation 25min;

(7) placing the fabric in the mixed solution obtained in step (6) for 50 minutes at a bath ratio of 1:40, and soaking for 50 minutes, taking out the fabric after soaking, and dehydrating for 6.5 minutes;

(8) Place the dehydrated fabric in step (7) under C-wave ultraviolet light for disinfection, the irradiation wavelength is 260nm, and the disinfection time is 25min;

(9) Smear the viscose layer on the fabric, and cover the mesh cover on the fabric to obtain an eccentric compressive dressing for venous closure treatment.

The consumption of each composition in each embodiment and each comparative example is as shown in table 1:

In each embodiment of table 1 and each comparative example, each component consumption table

Hemostasis test: The experimental rabbits were divided into 7 groups on average, including Examples 1-2 and Comparative Examples 1-5. The ears of the experimental rabbits were depilated and sterilized. Use a sterile scalpel to incise a 1cm-long bleeding port, including an aorta in the center of the ear, but the ear is not thorough to prevent blood from flowing out from the inside. After the blood fills the wound, follow-up coagulation tests are performed and weighed for vein The mass (m ₁ ) of the eccentric compressive dressing after the occlusive treatment was crushed to stop bleeding, and the eccentric compressive dressing used after the venous occlusive treatment was removed after 10 seconds to observe the hemostatic effect. When no more blood flows out from the bleeding port, record time T ₁ , and then observe every 5 seconds until complete hemostasis, record time T ₂ , and the hemostatic time is the average value of T ₁ and T ₂ . After the hemostasis is completed, the mass (m ₂ ) of the eccentric compressive dressing used for venous closure after the inhaled blood is weighed, and the amount of bleeding m=m ₂ −m ₁ is calculated.

Healing experiment: the mice were divided into 7 groups on average, including Examples 1-2 and Comparative Examples 1-5, anesthetized by intraperitoneal injection of 3% pentobarbital sodium 30mg/kg, depilated on both sides of the back spine of the mice, The depilated area was 4cm ² , and the depilated area was scalded with boiling water, and the wound surface was covered with an eccentric compression dressing used for venous closure treatment, and the dressing was changed once a day.

Table 1 The performance indicators of eccentric compression dressings used after venous closure therapy

From the various performance indicators of the eccentric compressive dressing used in Table 1 after venous closure treatment, adding hemostatic agents, sterilizing and disinfecting agents, scar-removing agents, analgesics and healing agents in Examples 1-3 shortened the bleeding Time, reduce bleeding, no infection, no scar, no restlessness and short healing time; in comparative example 1, there is no yellow dragon tail, iron amaranth, rich cabbage, seabuckthorn oil, sodium edetate, and the hemostasis time is significantly longer , the amount of bleeding is large; in comparative example 2, sterilizing and disinfecting agents, infection occurs at the bleeding port; in comparative example 3, there is no scar removing agent, and scars are left at the bleeding port; in comparative example 4, there is no analgesic; Severe restlessness appeared in the mice; there was no healing agent in Comparative Example 5, and the healing time of the wound surface of the mice was longer; therefore, Huanglongwei, Amaranth, Fuguicai, seabuckthorn oil, and sodium edetate can shorten the hemostasis time and reduce bleeding Bactericidal and disinfectant can inhibit the growth of bacteria, so that there is no infection on the wound surface; scar remover can antiseptic and promote muscle growth, so that there is no scar on the wound surface; analgesic can reduce swelling and pain; healing agent can promote wound healing and shorten the healing time .

The above descriptions are only preferred implementations of the present invention, and the protection scope of the present invention is not limited to the above-mentioned embodiments, and all technical solutions under the idea of the present invention belong to the protection scope of the present invention. It should be pointed out that for those skilled in the art, some improvements and modifications without departing from the principles of the present invention should also be regarded as the protection scope of the present invention.

Claims (10)

1. An eccentric compression dressing for venous closure therapy, characterized in that: it comprises hemostatic gauze, and the hemostatic gauze comprises fabric, a hemostatic agent and a bactericidal disinfectant impregnated in the fabric; The mass ratio of the hemostatic agent to the sterilization and disinfection agent is 1.3-1.5:0.6-0.9; The hemostatic agent is prepared from the following ingredients in parts by weight: 5-8 parts of huanglongwei, 8-10 parts of amaranth, 4-7 parts of rich cabbage, 5-9 parts of seabuckthorn oil, 3-3 parts of sodium edetate 6 parts, Panax notoginseng 2-4 parts, Sedum notoginseng 1-3 parts, Glauber's salt 2.5-3.5 parts, Rhubarb 1.5-2.5 parts, Sophora japonica 1-3 parts, Agrimony 3-4 parts, Artemisia argyi 3-4 parts , 1-3 parts of Puhuang; The sterilizing and disinfecting agent is prepared from the following ingredients in parts by weight: 9-11 parts of cassia bark, 5-9 parts of Qingyedan, 3-8 parts of ginseng and 2-5 parts of Angelica dahurica. 2. the eccentric compression dressing for venous closure treatment according to claim 1, characterized in that: said hemostatic gauze also includes scar remover, and the mass ratio of said scar remover to said hemostatic agent is 0.2-0.4:1.3-1.5, the scar remover is prepared from the following ingredients by weight: 4-9 parts of aloe vera juice, 2-6 parts of fresh cactus juice, and 1-4 parts of honey. 3. The eccentric compression dressing for venous closure treatment according to claim 1, wherein the hemostatic gauze also includes an analgesic, and the mass ratio of the analgesic to the hemostatic agent is 0.1-0.2:1.3-1.5, the analgesic includes 6-10 parts of vitamin B12, 3-6 parts of borneol, 4-7 parts of frankincense, and 1-4 parts of sumac. 4. The eccentric compression dressing for venous closure treatment according to claim 1, characterized in that: the hemostatic gauze also includes a healing agent, and the mass ratio of the healing agent to the hemostatic agent is 0.3- 0.5:1.3-1.5, the healing agent is prepared from the following ingredients by weight: 4-8 parts of vitamin B2, 5-10 parts of vitamin B6, and 4-9 parts of vitamin C. 5. The eccentric compression dressing for venous closure treatment according to claim 1, further comprising a mesh cover wrapped outside the hemostatic gauze to prevent the hemostatic gauze from spreading. 6. The eccentric compressive dressing for venous closure treatment according to claim 5, characterized in that: the side of the mesh cover in contact with the hemostatic gauze is provided with a dressing for adhering the mesh cover to the hemostatic gauze. adhesive layer on top. 7. The eccentric compression dressing for venous closure treatment according to claim 6, wherein the adhesive layer is prepared from the following components in parts by mass: 4-6 parts of nettle root, Bletilla striata 5-8 parts, 2-3 parts of dandelion, 3-4 parts of forsythia, 1-3 parts of puffball. 8. The eccentric compression dressing for venous closure treatment according to claim 5, characterized in that: the mesh cover is made of elastic material. 9. A production method for an eccentric compression dressing after venous closure treatment according to any one of claims 1-8, characterized in that: comprising the following steps: (1) The total weight is 3.5-4.7 times the total weight of 5-8 parts of Huanglongwei, 8-10 parts of Amaranth, 4-7 parts of Fuguicai, 5-9 parts of seabuckthorn oil and 3-6 parts of edetate sodium Add 5-8 parts of yellow dragon tail, 8-10 parts of iron amaranth, 4-7 parts of Fuguicai, 5-9 parts of seabuckthorn oil and 3-6 parts of sodium edetate to the boiling water in turn, fry Boil twice, each time for 1-2 hours, combine the decoction after decoction, and filter with a microporous membrane; (2) Add 2-4 parts of Panax notoginseng, 1-3 parts of Sedum notoginseng, 2.5-3.5 parts of Glauber's salt, 1.5-2.5 parts of rhubarb, 1-3 parts of Sophora japonica, 3- 4 parts of agrimony, 3-4 parts of mugwort leaves, 1-3 parts of Puhuang, decoct once for 2-3 hours, filter with a microporous membrane, concentrate the filtrate into a liquid medicine with a relative density of 0.46, spare; (3) Take 9-11 parts of cinnamon, 2-5 parts of Angelica dahurica, 3-8 parts of pure water with 4.6-5.8 times the total mass of ginseng, add 9-11 parts of cinnamon, 2-5 parts of ginseng to the boiling water Angelica dahurica, 3-8 parts of tail ginseng, and boiled, then add 5-9 parts of Qingyedan, decoct three times, each decocting for 2.5-3 hours, combine the decocted decoction, and filter with a microporous membrane, Concentrate the filtrate into a medicinal solution with a relative density of 0.43 for subsequent use; (4) Take 4-9 portions of aloe vera juice, heat it to 80-110°C, and slowly add 2-6 portions of cactus juice to the aloe vera juice at a speed of 300-500 rpm, stir evenly and heat up to 120-130°C ℃, increase the rotation speed to 600-800 rpm, add 1-4 parts of honey to the mixture, stir evenly, and set aside; (5) Take 3-6 parts of borneol, 4-7 parts of frankincense, 1-4 parts of sumac and 6-10 parts of vitamin B12 for ball milling, the ball-to-material ratio is 1.8:1, and the ball milling time is 20-60min. (6) Take 4-8 parts of vitamin B2, 5-10 parts of vitamin B6 and 4-9 parts of vitamin C for ball milling and pulverization, the ball-to-material ratio is 1.6:1, and the ball milling time is 30-50min, and set aside; (7) Heat the liquid obtained in step (2) to 100-120 ° C, and at a speed of 200-300 rpm, the liquid obtained in step (3) and step (4), and the liquid obtained in step (5) and step The mixed powder of gained in (6) is added in the liquid of step (2) gained successively, be down to normal temperature after being incubated 20-30min; (8) placing the fabric in the mixed solution obtained in step (7) for 40-60 min at a bath ratio of 1:30-50, and then taking out the soaked fabric and dehydrating for 5-8 min; (9) placing the dehydrated fabric in step (8) under ultraviolet light for disinfection, the disinfection time is 20-30min; (10) Smear the viscose layer on the fabric, and put the mesh cover on the fabric to obtain an eccentric compressive dressing for venous closure treatment. 10. The production method for eccentric compression dressings after venous closure therapy according to claim 9, characterized in that: in the step (9), the ultraviolet rays refer to C-wave ultraviolet rays, and the irradiation wavelength is 250-270nm.